DT-Web

DB01037 - Selegiline


Identification
Name Selegiline
Accession Number DB01037 (APRD00525)
Type small molecule
Description A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 187.2808
Groups approved
Monoisotopic Weight 187.136099549
Pharmacology
Indication Monotherapy for initial treatment of Parkinson's disease, as well as an adjunct therapy in patients with a decreased response to levodopa/carbadopa. Also used for the palliative treatment of mild to moderate Alzheimer's disease and at higher doses, for the treatment of depression.
Mechanism of action Although the mechanisms for selegiline's beneficial action in the treatment of Parkinson's disease are not fully understood, the selective, irreversible inhibition of monoamine oxidase type B (MAO-B) is thought to be of primary importance. MAO-B is involved in the oxidative deamination of dopamine in the brain. Selegiline binds to MAO-B within the nigrostriatal pathways in the central nervous system, thus blocking microsomal metabolism of dopamine and enhancing the dopaminergic activity in the substantial nigra. Selegiline may also increase dopaminergic activity through mechanisms other than inhibition of MAO-B. At higher doses, selegiline can also inhibit monozmine oxidase type A (MAO-A), allowing it to be used for the treatment of depression.
Absorption Rapidly absorbed from the gastrointestinal tract.
Protein binding > 99.5%
Biotransformation Not Available
Route of elimination Not Available
Toxicity LD50=63 mg/kg (rats, IV)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bezafibrate MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) like selegiline.
Brimonidine MAO Inhibitors like selegiline may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
Buprenorphine Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like selegiline. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Citalopram Possible severe adverse reaction with this combination
Desvenlafaxine Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Dextromethorphan Combination associated with possible serotoninergic syndrome
Escitalopram Possible severe adverse reaction with this combination
Fluoxetine Possible severe adverse reaction with this combination
Fluvoxamine Possible severe adverse reaction with this combination
Meperidine Potentially fatal adverse effects
Moclobemide Decrease in selectivity
Paroxetine Possible severe adverse reaction with this combination
Tapentadol Increases the toxicity of tapentadol by unknown mechanism. Discontinue selegiline at least 14 days prior to tapentadol administration.
Tetrabenazine Tetrabenazine may increase the adverse/toxic effects of Selegiline. Concomitant therapy is contraindicated.
Thiotepa Thiotepa, a strong CYP2B6 inhibitor, may decrease the metabolism and clearance of Selegiline, a CYP2B6 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Selegiline if Thiotepa is initiated, discontinued or dose changed.
Tolcapone Tolcapone and Selegiline decrease the metabolism of endogenous catecholamines. Concomitant therapy may result in increased catecholamine effects. Consider alternate therapy or use cautiously and monitor for increased catecholamine effects.
Tramadol Tramadol increases the risk of serotonin syndrome and seizure induction by the MAO inhibitor, Selegiline.
Tranylcypromine Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Avoid combination or monitor for symptoms of serotonin syndrome and/or hypertensive crisis.
Venlafaxine Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Vilazodone MAO Inhibitors may enhance the serotonergic effect of Selective Serotonin Reuptake Inhibitors. This may cause serotonin syndrome. Avoid combination.
Zolmitriptan The MAO inhibitor, selegiline, may increase the serum concentration of zolmitriptan by decreasing its metabolism. Concomitant therapy and use of zolmitriptan within two weeks of discontinuing selegiline are contraindicated.
Food Interactions
  • Food increases the oral bioavailability by 3-5 fold.

Targets


Amine oxidase [flavin-containing] B
Name Amine oxidase [flavin-containing] B
Gene Name MAOB
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Chrisp P, Mammen GJ, Sorkin EM: Selegiline. A review of its pharmacology, symptomatic benefits and protective potential in Parkinson's disease. Drugs Aging. 1991 May;1(3):228-48. - Pubmed
  • Heinonen EH, Myllyla V: Safety of selegiline (deprenyl) in the treatment of Parkinson's disease. Drug Saf. 1998 Jul;19(1):11-22. - Pubmed
  • Selegiline: a second look. Six years later: too risky in Parkinson's disease. Prescrire Int. 2002 Aug;11(60):108-11. - Pubmed
  • Macleod AD, Counsell CE, Ives N, Stowe R: Monoamine oxidase B inhibitors for early Parkinson's disease. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004898. - Pubmed
  • Magyar K, Tothfalusi L: Pharmacokinetic aspects of deprenyl effects. Pol J Pharmacol Pharm. 1984 Jul-Aug;36(4):373-84. - Pubmed
  • Heinonen EH, Anttila MI, Lammintausta RA: Pharmacokinetic aspects of l-deprenyl (selegiline) and its metabolites. Clin Pharmacol Ther. 1994 Dec;56(6 Pt 2):742-9. - Pubmed
  • Deleu D, Northway MG, Hanssens Y: Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease. Clin Pharmacokinet. 2002;41(4):261-309. - Pubmed
  • Patkar AA, Pae CU, Masand PS: Transdermal selegiline: the new generation of monoamine oxidase inhibitors. CNS Spectr. 2006 May;11(5):363-75. - Pubmed
  • Azzaro AJ, Ziemniak J, Kemper E, Campbell BJ, VanDenBerg C: Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules. J Clin Pharmacol. 2007 Oct;47(10):1256-67. Epub 2007 Aug 22. - Pubmed
  • Lee KC, Chen JJ: Transdermal selegiline for the treatment of major depressive disorder. Neuropsychiatr Dis Treat. 2007;3(5):527-37. - Pubmed
  • Baker GB, Sowa B, Todd KG: Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders? J Psychiatry Neurosci. 2007 Sep;32(5):313-5. - Pubmed
DTHybrid score 0.9853
Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Pharmacological action no
Actions inhibitor
References
  • Patkar AA, Pae CU, Masand PS: Transdermal selegiline: the new generation of monoamine oxidase inhibitors. CNS Spectr. 2006 May;11(5):363-75. - Pubmed
  • Azzaro AJ, Ziemniak J, Kemper E, Campbell BJ, VanDenBerg C: Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules. J Clin Pharmacol. 2007 Oct;47(10):1256-67. Epub 2007 Aug 22. - Pubmed
  • Lee KC, Chen JJ: Transdermal selegiline for the treatment of major depressive disorder. Neuropsychiatr Dis Treat. 2007;3(5):527-37. - Pubmed
  • Baker GB, Sowa B, Todd KG: Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders? J Psychiatry Neurosci. 2007 Sep;32(5):313-5. - Pubmed
DTHybrid score 0.5887

Enzymes


Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Culpepper L, Kovalick LJ: A review of the literature on the selegiline transdermal system: an effective and well-tolerated monoamine oxidase inhibitor for the treatment of depression. Prim Care Companion J Clin Psychiatry. 2008;10(1):25-30. - Pubmed
  • Lee KC, Chen JJ: Transdermal selegiline for the treatment of major depressive disorder. Neuropsychiatr Dis Treat. 2007;3(5):527-37. - Pubmed
  • Benetton SA, Fang C, Yang YO, Alok R, Year M, Lin CC, Yeh LT: P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine. Drug Metab Pharmacokinet. 2007 Apr;22(2):78-87. - Pubmed
  • Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4313
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Benetton SA, Fang C, Yang YO, Alok R, Year M, Lin CC, Yeh LT: P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine. Drug Metab Pharmacokinet. 2007 Apr;22(2):78-87. - Pubmed
DTHybrid score 0.857
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Lee KC, Chen JJ: Transdermal selegiline for the treatment of major depressive disorder. Neuropsychiatr Dis Treat. 2007;3(5):527-37. - Pubmed
  • Benetton SA, Fang C, Yang YO, Alok R, Year M, Lin CC, Yeh LT: P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine. Drug Metab Pharmacokinet. 2007 Apr;22(2):78-87. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3932
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6138
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.59
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4677
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6756
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6658
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4116

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score 0.5102

Predictions


Id Partner name Gene Name Score
4118 Cytochrome P450 3A5 CYP3A5 0.2895
6107 Cytochrome P450 3A7 CYP3A7 0.2117
6024 Cytochrome P450 1A1 CYP1A1 0.202
824 Sodium-dependent serotonin transporter SLC6A4 0.1501
20 Prostaglandin G/H synthase 1 PTGS1 0.1341
587 Serum albumin ALB 0.1337
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1312
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1146
713 Sodium-dependent dopamine transporter SLC6A3 0.1092
492 Histamine H1 receptor HRH1 0.1038
6106 Cytochrome P450 2C18 CYP2C18 0.0992
3811 Cytochrome P450 19A1 CYP19A1 0.0953
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0871
556 Alpha-1A adrenergic receptor ADRA1A 0.0871
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0859
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0852
502 5-hydroxytryptamine 2A receptor HTR2A 0.0803
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0798
831 D(2) dopamine receptor DRD2 0.0766
318 Alpha-2A adrenergic receptor ADRA2A 0.0728
1729 Solute carrier family 22 member 6 SLC22A6 0.0708
862 Multidrug resistance-associated protein 1 ABCC1 0.07
6145 Solute carrier family 22 member 1 SLC22A1 0.069
290 Prostaglandin G/H synthase 2 PTGS2 0.0671
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0667
220 Sodium channel protein type 5 subunit alpha SCN5A 0.065
6144 Solute carrier family 22 member 2 SLC22A2 0.064
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0632
1898 Cytochrome P450 1B1 CYP1B1 0.0625
766 Beta-2 adrenergic receptor ADRB2 0.0622
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0589
885 5-hydroxytryptamine 1B receptor HTR1B 0.0579
193 Beta-1 adrenergic receptor ADRB1 0.057
320 5-hydroxytryptamine 1A receptor HTR1A 0.0565
118 Organic cation/carnitine transporter 2 SLC22A5 0.0561
23 D(1A) dopamine receptor DRD1 0.0547
725 5-hydroxytryptamine 1D receptor HTR1D 0.0533
590 5-hydroxytryptamine 2C receptor HTR2C 0.0512
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0506
136 Estrogen receptor ESR1 0.0505
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0498
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0493
776 Bile salt export pump ABCB11 0.0486
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0485
632 Alpha-1B adrenergic receptor ADRA1B 0.0469
131 Synaptic vesicular amine transporter SLC18A2 0.0468
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0462
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0461
260 Cytochrome P450 51 ERG11 0.0459
761 Cytochrome P450 51 ERG11 0.0459
3163 Cytochrome P450 51 cyp51 0.0459
6147 Solute carrier family 22 member 3 SLC22A3 0.0443
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0436
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.042
511 5-hydroxytryptamine 1F receptor HTR1F 0.042
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0419
847 Mu-type opioid receptor OPRM1 0.0416
731 HIV-1 protease HIV-1 protease 0.0415
3810 Catechol O-methyltransferase COMT 0.0414
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0412
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.041
871 Glucocorticoid receptor NR3C1 0.0408
341 5-hydroxytryptamine 3 receptor HTR3A 0.0405
465 Calmodulin CALM1 0.0405
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0399
468 Cytochrome P450 4A11 CYP4A11 0.0398
146 Androgen receptor AR 0.0398
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0389
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0387
2164 Multidrug resistance-associated protein 4 ABCC4 0.0384
6142 Solute carrier family 22 member 8 SLC22A8 0.0384
6031 Cytochrome P450 3A43 CYP3A43 0.038
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0371
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0358
6143 Solute carrier family 22 member 7 SLC22A7 0.0357
467 Delta-type opioid receptor OPRD1 0.0355
789 Alpha-1D adrenergic receptor ADRA1D 0.0352
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0345
696 Kappa-type opioid receptor OPRK1 0.0343
629 Alpha-2B adrenergic receptor ADRA2B 0.0338
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0337
817 DNA topoisomerase 2-alpha TOP2A 0.0336
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.033
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0329
638 D(3) dopamine receptor DRD3 0.0323
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0313
833 Organic cation/carnitine transporter 1 SLC22A4 0.0313
6014 Cytochrome P450 2A13 CYP2A13 0.0311
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.031
122 P2Y purinoceptor 12 P2RY12 0.0308
378 Alpha-2C adrenergic receptor ADRA2C 0.0306
3923 Cholinesterase BCHE 0.0305
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0305
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0282
891 Dihydropteroate synthase folP 0.0276
5359 Dihydropteroate synthase folP 0.0276
7175 Dihydropteroate synthase sulI 0.0276
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0271
1757 Myeloperoxidase MPO 0.027
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.027
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0264
36 Insulin receptor INSR 0.0258
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0257
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0256
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0256
436 5-hydroxytryptamine 2B receptor HTR2B 0.0252
6182 Cytochrome P450 2J2 CYP2J2 0.0245
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0242
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0238
2864 Penton protein PIII 0.0236
6102 Arylamine N-acetyltransferase 2 NAT2 0.0235
432 D(4) dopamine receptor DRD4 0.0228
273 Apoptosis regulator Bcl-2 BCL2 0.0228
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0225
482 Glycine receptor subunit alpha-1 GLRA1 0.0221
1656 CYP2B protein CYP2B 0.022
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0218
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0218
4604 Liver carboxylesterase 1 CES1 0.0218
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0215
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0215
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0214
6136 Multidrug resistance-associated protein 5 ABCC5 0.0212
238 Peroxisome proliferator-activated receptor gamma PPARG 0.021
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.021
1024 Solute carrier family 22 member 11 SLC22A11 0.0208
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0207
5841 Insulin-like growth factor IB IGF1 0.0206
777 Tumor necrosis factor TNF 0.0203
477 DNA topoisomerase 4 subunit A parC 0.0201
886 DNA topoisomerase 4 subunit A parC 0.0201
6226 DNA topoisomerase 4 subunit A parC 0.0201
70 Type-1 angiotensin II receptor AGTR1 0.0199
869 Estrogen receptor beta ESR2 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
844 Epidermal growth factor receptor EGFR 0.0198
404 DNA gyrase subunit A gyrA 0.0198
6224 DNA gyrase subunit A gyrA 0.0198
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0197
4120 NADPH--cytochrome P450 reductase POR 0.0196
811 Translocator protein TSPO 0.0196
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0194
6141 Sodium/bile acid cotransporter SLC10A1 0.0193
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0192
504 Mast/stem cell growth factor receptor KIT 0.0192
6220 Aryl hydrocarbon receptor AHR 0.0191
380 Cytochrome P450 17A1 CYP17A1 0.019
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0188
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0187
124 Histamine H2 receptor HRH2 0.0186
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0186
16 Adenosine A1 receptor ADORA1 0.0185
474 Acetylcholinesterase ACHE 0.0183
1010 Cytochrome P450 51A1 CYP51A1 0.0182
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0182
94 5-hydroxytryptamine 4 receptor HTR4 0.0182
537 ATP synthase delta chain, mitochondrial ATP5D 0.0182
158 Sodium channel protein type 1 subunit alpha SCN1A 0.018
6137 Multidrug resistance-associated protein 6 ABCC6 0.0179
6148 Multidrug resistance-associated protein 7 ABCC10 0.0178
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0178
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0177
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0177
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0177
705 Glutamate receptor 1 GRIA1 0.0176
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0174
614 Progesterone receptor PGR 0.0174
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0174
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0173
716 5-hydroxytryptamine 7 receptor HTR7 0.0172
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0171
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0171
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0169
1178 Adenosine A2a receptor ADORA2A 0.0168
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0167
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0167
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0167
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0167
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0166
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0165
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0165
161 Tubulin beta chain TUBB 0.0164
312 Tubulin beta chain TUB2 0.0164
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0163
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0162
163 D(1B) dopamine receptor DRD5 0.0161
818 50S ribosomal protein L10 rplJ 0.016
756 Sex hormone-binding globulin SHBG 0.0158
3947 Xanthine dehydrogenase/oxidase XDH 0.0156
1192 Sulfotransferase 1A1 SULT1A1 0.0155
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0155
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0152
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0152
373 Transthyretin TTR 0.0151
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.015
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
407 Vascular endothelial growth factor receptor 2 KDR 0.0149
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0149
295 Carbonic anhydrase 1 CA1 0.0148
1636 Trace amine-associated receptor 1 TAAR1 0.0148
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0146
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0145
26 Vascular endothelial growth factor receptor 3 FLT4 0.0143
365 Dihydrofolate reductase DHFR 0.0143
2381 Dihydrofolate reductase DFR1 0.0143
2833 Dihydrofolate reductase Not Available 0.0143
2931 Dihydrofolate reductase folA 0.0143
3544 Dihydrofolate reductase folA 0.0143
3682 Dihydrofolate reductase folA 0.0143
6642 Dihydrofolate reductase folA 0.0143
6756 Dihydrofolate reductase dfrA 0.0143
921 Glutamate receptor 2 GRIA2 0.0142
1517 Beta-3 adrenergic receptor ADRB3 0.0142
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0141
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0138
32 Vascular endothelial growth factor receptor 1 FLT1 0.0137
592 Carbonic anhydrase 4 CA4 0.0137
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0136
29 Tubulin beta-1 chain TUBB1 0.0135
232 Corticosteroid-binding globulin SERPINA6 0.0135
174 Sigma 1-type opioid receptor SIGMAR1 0.0133
952 Dipeptidyl peptidase 4 DPP4 0.0133
1483 Membrane copper amine oxidase AOC3 0.0133
6020 Aldehyde oxidase AOX1 0.0131
3917 Methylenetetrahydrofolate reductase MTHFR 0.0131
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0131
4116 Dihydropteroate synthetase Not Available 0.0131
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0131
228 Beta platelet-derived growth factor receptor PDGFRB 0.0129
4237 50S ribosomal protein L22 rplV 0.0127
571 Melatonin receptor type 1A MTNR1A 0.0122
518 Peroxidase/catalase T katG 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
4122 Histone deacetylase 2 HDAC2 0.0122
251 Alcohol dehydrogenase 1A ADH1A 0.0121
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0121
427 Substance-P receptor TACR1 0.0121
153 Dopamine beta-hydroxylase DBH 0.012
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.012
3913 Glutamic acid decarboxylase GAD65 0.012
275 Arachidonate 5-lipoxygenase ALOX5 0.012
444 Alcohol dehydrogenase 1B ADH1B 0.0119
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0117
4238 50S ribosomal protein L4 rplD 0.0117
5578 50S ribosomal protein L4 rplD 0.0117
6173 50S ribosomal protein L4 rplD 0.0117
6219 50S ribosomal protein L4 rplD 0.0117
3932 Glutathione S-transferase A2 GSTA2 0.0117
563 Thyroid peroxidase TPO 0.0116
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0114
2230 Catalase CAT 0.0114
3249 Catalase katA 0.0114
3625 Catalase katA 0.0114
4539 Catalase katA 0.0114
4941 Catalase katB 0.0114
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0112
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0112
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0112
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0111
6126 Carbonic anhydrase 7 CA7 0.011
528 5-hydroxytryptamine 1E receptor HTR1E 0.0109
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0109
613 Atrial natriuretic peptide receptor A NPR1 0.0106
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0106
737 Mineralocorticoid receptor NR3C2 0.0106
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0106
5698 Riboflavin synthase alpha chain ribE 0.0105
6138 Multidrug resistance protein 3 ABCB4 0.0105
357 Carbonic anhydrase 2 CA2 0.0103
6085 Fatty acid-binding protein, intestinal FABP2 0.0103
1256 5-hydroxytryptamine 6 receptor HTR6 0.0102
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0102
408 Riboflavin kinase RFK 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.01
738 Monocarboxylate transporter 1 SLC16A1 0.0099
735 Alanine aminotransferase 1 GPT 0.0098
3904 Alanine aminotransferase 2 GPT2 0.0098
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0097
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0097
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0097
68 Cannabinoid receptor 1 CNR1 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
6432 Transporter snf 0.0097
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0096
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0096
49 Endothelin B receptor EDNRB 0.0096
517 Alcohol dehydrogenase 1C ADH1C 0.0096
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0095
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0094
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0094
88 Retinoic acid receptor RXR-beta RXRB 0.0091
823 Fibroblast growth factor receptor 2 FGFR2 0.0091
24 Thymidylate synthase TMP1 0.0091
359 Thymidylate synthase TYMS 0.0091
2626 Thymidylate synthase thyA 0.0091
2729 Thymidylate synthase thyA 0.0091
5352 Thymidylate synthase THYA 0.0091
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.009
578 Endothelin-1 receptor EDNRA 0.009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.009
1050 Bile salt sulfotransferase SULT2A1 0.009
84 Nuclear receptor 0B1 NR0B1 0.009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0089
319 Opioid receptor, sigma 1 OPRS1 0.0089
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0089
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0088
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0088
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0087
284 DNA-directed RNA polymerase beta chain rpoB 0.0087
5773 DNA-directed RNA polymerase beta chain rpoB 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
1618 High affinity nerve growth factor receptor NTRK1 0.0086
6174 50S ribosomal protein L32 rpmF 0.0086
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0085
3809 Estrogen-related receptor gamma ESRRG 0.0084
904 Glutathione S-transferase P GSTP1 0.0084
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0083
1275 Estrogen sulfotransferase SULT1E1 0.0083
183 Vascular endothelial growth factor A VEGFA 0.0082
1629 Transcription factor AP-1 JUN 0.0082
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0081
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0081
4203 Histamine N-methyltransferase HNMT 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
814 Ryanodine receptor 1 RYR1 0.008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0079
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
2112 Toll-like receptor 9 TLR9 0.0079
239 Coagulation factor X F10 0.0079
173 Toll-like receptor 7 TLR7 0.0079
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0077
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0077
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0077
780 Retinoic acid receptor RXR-gamma RXRG 0.0077
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0076
2449 Tubulin alpha-3 chain TUBA1A 0.0076
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0076
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0075
654 Flavin reductase BLVRB 0.0075
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0074
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0074
1541 Metalloproteinase mmp20 0.0074
7 Nitric oxide synthase, inducible NOS2 0.0074
2539 Tubulin alpha-1 chain TUBA4A 0.0073
1353 DNA topoisomerase 1 TOP1 0.0072
3552 DNA topoisomerase 1 topA 0.0072
106 Cannabinoid receptor 2 CNR2 0.0072
694 Matrix protein 2 M 0.0071
3937 Fatty-acid amide hydrolase FAAH 0.0071
856 Vitamin D3 receptor VDR 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
5300 Antigen peptide transporter 1 TAP1 0.0071
4311 tRNA TRDMT1 0.0071
4325 tRNA trmD 0.0071
4328 tRNA trmD 0.0071
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.007
469 Annexin A1 ANXA1 0.007
6146 High affinity copper uptake protein 1 SLC31A1 0.0069
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0068
634 Squalene monooxygenase SQLE 0.0068
7196 Squalene monooxygenase ERG1 0.0068
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0066
4103 Proteasome subunit beta type 2 PSMB2 0.0066
4102 Proteasome subunit beta type 5 PSMB5 0.0066
4101 Proteasome subunit beta type 1 PSMB1 0.0066
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0066
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
162 Retinoic acid receptor gamma-1 RARG 0.0066
6766 O-GlcNAcase BT_4395 BT_4395 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
581 Cytochrome P450 2R1 CYP2R1 0.0065
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0065
165 FL cytokine receptor FLT3 0.0065
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0064
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
976 Platelet glycoprotein IX GP9 0.0063
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
6044 Serum paraoxonase/lactonase 3 PON3 0.0062
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0061
2298 Cytochrome P450-cam camC 0.0061
54 Prothrombin F2 0.0061
185 Vasopressin V1a receptor AVPR1A 0.006
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0059
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0059
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0059
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0059
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0059
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0059
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
5880 Thrombopoietin receptor MPL 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
3856 Fibroblast growth factor receptor 3 FGFR3 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
723 Cytosolic phospholipase A2 PLA2G4A 0.0056
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0056
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0055
1630 Integrin beta-2 ITGB2 0.0055
6131 Carbonic anhydrase 14 CA14 0.0055
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
5934 Cytochrome P450 26A1 CYP26A1 0.0055
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0055
6506 Stathmin-4 STMN4 0.0055
3957 Adenosine deaminase ADA 0.0055
908 Glutathione S-transferase theta-1 GSTT1 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
164 Histamine H4 receptor HRH4 0.0054
65 Matrix metalloproteinase-9 Not Available 0.0054
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0054
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0054
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0054
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0054
4217 Telomerase reverse transcriptase TERT 0.0053
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0053
1852 Microtubule-associated protein 2 MAP2 0.0053
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6043 Putative G-protein coupled receptor 44 GPR44 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
714 Glutathione reductase, mitochondrial GSR 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
5787 Angiopoietin-1 receptor TEK 0.0052
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0052
1992 Vitamin D-binding protein GC 0.0052
6122 Carbonic anhydrase 3 CA3 0.0052
712 Tubulin alpha chain TUB1 0.0052
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
2207 Rhodopsin RHO 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0051
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0051
3808 Dihydropteroate synthase 2 folP2 0.0051
3601 Dihydropteroate synthase 1 folP1 0.0051
3807 Dihydropteroate synthase 1 folP1 0.0051
1360 Sphingomyelin phosphodiesterase SMPD1 0.0049
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0049
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0049
3404 Exotoxin A eta 0.0049
2981 Phospholipase A2, membrane associated PLA2G2A 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
2616 Ganglioside GM2 activator GM2A 0.0047
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0047
683 Potassium transporter GK0582 0.0047
1253 Interferon gamma IFNG 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
719 Retinoic acid receptor responder protein 1 RARRES1 0.0045
770 Retinoic acid-induced protein 3 GPRC5A 0.0045
527 Prostacyclin receptor PTGIR 0.0045
1039 Histone deacetylase 9 HDAC9 0.0045
3086 Plasmepsin-2 Not Available 0.0045
6134 Sodium channel subunit beta-3 SCN3B 0.0045
6133 Sodium channel subunit beta-2 SCN2B 0.0045
6132 Sodium channel subunit beta-1 SCN1B 0.0045
6135 Sodium channel subunit beta-4 SCN4B 0.0045
6127 Carbonic anhydrase-related protein CA8 0.0045
6129 Carbonic anhydrase-related protein 11 CA11 0.0045
6128 Carbonic anhydrase-related protein 10 CA10 0.0045
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0045
6149 Solute carrier family 22 member 10 SLC22A10 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
820 Glycine receptor subunit alpha-2 GLRA2 0.0045
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0044
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
1268 Neuropeptide S receptor NPSR1 0.0044
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0044
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0044
1374 Natriuretic peptides B NPPB 0.0044
1827 Gap junction alpha-1 protein GJA1 0.0044
1908 Vascular cell adhesion protein 1 VCAM1 0.0044
751 Potassium channel subfamily K member 6 KCNK6 0.0044
130 Prostacyclin synthase PTGIS 0.0044
936 Ephrin type-A receptor 2 EPHA2 0.0043
117 Sterol O-acyltransferase 1 SOAT1 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0042
6130 Carbonic anhydrase 13 CA13 0.0042
291 Nitric-oxide synthase, endothelial NOS3 0.0042
2320 Thymidine kinase, cytosolic TK1 0.0042
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0042
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0042
4192 DNA topoisomerase 2-beta TOP2B 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
3007 Carbonic anhydrase 12 CA12 0.0041
4205 Carbonic anhydrase 9 CA9 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
400 Coagulation factor IX F9 0.004
5461 Coagulation factor IX F9 0.004
730 Retinoic acid receptor alpha RARA 0.004
172 Potassium channel subfamily K member 1 KCNK1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
268 Adenosine A2b receptor ADORA2B 0.004
569 Retinal dehydrogenase 2 ALDH1A2 0.004
6073 Potassium channel subfamily K member 9 KCNK9 0.004
6072 Potassium channel subfamily K member 3 KCNK3 0.004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0039
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
4225 Uridine phosphorylase 1 UPP1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
85 Growth hormone receptor GHR 0.0038
611 Retinal dehydrogenase 1 ALDH1A1 0.0037
594 Thyroxine-binding globulin SERPINA7 0.0037
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0037
604 Vitamin K-dependent protein Z PROZ 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
33 Cystine/glutamate transporter SLC7A11 0.0037
4773 Deoxycytidine kinase DCK 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
758 Thyroid hormone receptor alpha THRA 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
1245 Vitamin K-dependent protein S PROS1 0.0034
422 Vitamin K-dependent protein C PROC 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0033
327 Glutathione reductase gor 0.0033
5110 Glutathione reductase GR2 0.0033
896 Glutathione S-transferase Mu 1 GSTM1 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
572 Integrin alpha-L ITGAL 0.0032
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0032
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
267 Plasminogen activator inhibitor 1 SERPINE1 0.0031
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
6163 Copper-transporting ATPase 2 ATP7B 0.0031
6165 Copper-transporting ATPase 1 ATP7A 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
448 Vitamin K-dependent gamma-carboxylase GGCX 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
1864 RET proto-oncogene RET 0.0029
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0029
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0029
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0029
6048 Troponin C, skeletal muscle TNNC2 0.0029
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
6459 Glycodelin PAEP 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
6221 Steroid hormone receptor ERR1 ESRRA 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
798 Osteocalcin BGLAP 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
358 Cystathionine beta-synthase CBS 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6677 Myelin P2 protein PMP2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
6859 Protein S100-A4 S100A4 0.0025
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3830 Calreticulin CALR 0.0025
369 Coagulation factor VII F7 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0025
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0025
2268 Cholesterol oxidase choB 0.0025
2822 Cholesterol oxidase choA 0.0025
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6218 Pannexin-1 PANX1 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0024
760 Fibroblast growth factor 1 FGF1 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
76 Nitric-oxide synthase, brain NOS1 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
1341 Histamine H3 receptor HRH3 0.0023
3221 Cytochrome c4 cc4 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
3102 Flavohemoprotein hmp 0.002
4969 Flavohemoprotein hmp 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0018
1063 Signal transducer and activator of transcription 5B STAT5B 0.0018
1650 Heme carrier protein 1 SLC46A1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
4486 Phenol 2-hydroxylase component B pheA2 0.0018
4477 Dihydrolipoyl dehydrogenase lpdV 0.0018
5077 Dihydrolipoyl dehydrogenase Not Available 0.0018
5117 Dihydrolipoyl dehydrogenase lpd 0.0018
4439 Ferredoxin reductase bphA4 0.0018
5078 Amine oxidase, flavin-containing PSPTO1126 0.0018
526 Thioredoxin reductase trxB 0.0018
3767 Thioredoxin reductase trxB 0.0018
5122 Mersacidin decarboxylase mrsD 0.0017
5095 Putidaredoxin reductase camA 0.0017
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0017
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0017
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0017
5109 Outer membrane protein p64k or PM-6 m-6 0.0017
5115 FkbI fkbI 0.0017
3133 UDP-galactopyranose mutase glf 0.0017
5099 UDP-galactopyranose mutase glf 0.0017
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0017
3763 5,10-methylenetetrahydrofolate reductase metF 0.0017
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0017
5094 5,10-methylenetetrahydrofolate reductase metF 0.0017
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0017
5111 Phenylacetone monooxygenase pamO 0.0017
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0017
5083 Cryptochrome DASH cry 0.0017
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0017
5081 L-aspartate oxidase nadB 0.0017
1410 Oxidoreductase HSD17B6 0.0017
4725 Oxidoreductase Not Available 0.0017
5124 Oxidoreductase Not Available 0.0017
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
3233 Bile acid receptor NR1H4 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
4440 NADH peroxidase npr 0.0015
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0015
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0015
3594 Deoxyribodipyrimidine photo-lyase phr 0.0015
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0015
5080 Deoxyribodipyrimidine photo-lyase phr 0.0015
6755 Poliovirus receptor PVR 0.0015
5072 N,N-dimethylglycine oxidase dmg 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0015
2470 Pyruvate oxidase pox5 0.0015
702 UMP-CMP kinase CMPK1 0.0015
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0015
5073 Ferredoxin--NADP reductase petH 0.0015
5076 Ferredoxin--NADP reductase fpr 0.0015
5119 Ferredoxin--NADP reductase petH 0.0015
5121 Ferredoxin--NADP reductase fpr 0.0015
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0015
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0015
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0015
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0015
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0015
2526 NADPH-ferredoxin reductase fprA fprA 0.0015
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0015
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0015
6689 TraN protein traN 0.0015
6672 Destrin DSTN 0.0015
6680 Cofilin-1 CFL1 0.0015
6670 Ig kappa chain V-I region Bi Not Available 0.0015
6671 Ig heavy chain V-III region VH26 Not Available 0.0015
6688 TraF protein traF 0.0015
6404 Rhomboid protease glpG glpG 0.0015
6797 Rhomboid protease glpG glpG 0.0015
3710 Acyl-CoA thioesterase 2 tesB 0.0015
6685 Outer membrane protein II porB 0.0015
6690 BenF-like porin PFL_1329 0.0015
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0015
6687 TraO protein traO 0.0015
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0015
6679 Colicin-Ia cia 0.0015
6676 Fe(3+)-pyochelin receptor fptA 0.0015
115 Penicillin-binding protein 2 mrdA 0.0015
6069 Penicillin-binding protein 2 mrdA 0.0015
6118 Penicillin-binding protein 2 penA 0.0015
6187 Penicillin-binding protein 2 pbpA 0.0015
6686 Penicillin-binding protein 2 pbp2 0.0015
6939 Penicillin-binding protein 2 mrdA 0.0015
7163 Penicillin-binding protein 2 pbpA 0.0015
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0015
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0015
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
126 D-lactate dehydrogenase dld 0.0014
3545 D-lactate dehydrogenase Not Available 0.0014
4510 D-lactate dehydrogenase ldhA 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0014
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0014
2893 Glycine oxidase thiO 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0013
2567 Thymidylate synthase thyX thyX 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
2823 Trypanothione reductase TPR 0.0013
2769 P-hydroxybenzoate hydroxylase pobA 0.0013
2809 P-hydroxybenzoate hydroxylase pobA 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0013
4760 Mll3241 protein mll3241 0.0013
3395 Iron(III) dicitrate transport protein fecA fecA 0.0013
6385 H subunit of photosynthetic reaction center complex puhA 0.0013
6474 Outer membrane protein W ompW 0.0013
6678 Colicin I receptor cirA 0.0013
3578 Protein crcA crcA 0.0013
6675 Colicin-E3 ceaC 0.0013
2925 Long-chain fatty acid transport protein fadL 0.0013
6480 Outer membrane usher protein papC papC 0.0013
6438 Outer membrane protein G ompG 0.0013
2447 Ammonia channel amtB 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2380 Monomeric sarcosine oxidase soxA 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6645 D-amino-acid oxidase DAO 0.0012
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0012
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0012
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
6524 Protein tonB tonB 0.0012
2679 Vitamin B12 transporter btuB btuB 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6352 Reaction center protein H chain puhA 0.001
6456 Reaction center protein H chain puhA 0.001
6682 Reaction center protein H chain puhA 0.001
6353 Reaction center protein L chain pufL 0.001
6454 Reaction center protein L chain pufL 0.001
6683 Reaction center protein L chain pufL 0.001
6354 Reaction center protein M chain pufM 0.001
6455 Reaction center protein M chain pufM 0.001
6684 Reaction center protein M chain pufM 0.001
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
997 Protein kinase C beta type PRKCB 0.0009
2828 Squalene--hopene cyclase shc 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
822 Aldose reductase AKR1B1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
693 Hemoglobin subunit beta HBB 0.0004
5818 Folate receptor alpha FOLR1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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