DT-Web

DB00484 - Brimonidine


Identification
Name Brimonidine
Accession Number DB00484 (APRD00034)
Type small molecule
Description Brimonidine is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 292.135
Groups approved
Monoisotopic Weight 291.011957992
Pharmacology
Indication For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Mechanism of action Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2). It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.
Absorption Minimal systemic absorption occurs after ocular insertion.
Protein binding Not Available
Biotransformation Metabolized primarily by the liver.
Route of elimination It is metabolized primarily by the liver. Urinary excretion is the major route of elimination of the drug and its metabolites.
Toxicity Oral LD50 is 50 mg/kg in mice and 100 mg/kg in rats.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Droperidol Droperidol may enhance the CNS depressant effect of brimonidine. Consider therapy modification.
Isocarboxazid MAO Inhibitors like isocarboxazid may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
Linezolid MAO Inhibitors like linezolid may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
Methotrimeprazine Brimonidine may enhance the CNS depressant effect of Methotrimeprazine. Methotrimeprazine may enhance the CNS depressant effect of brimonidine. Consider therapy modification.
Moclobemide MAO Inhibitors like moclobemide may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
Phenelzine MAO Inhibitors like phenelzine may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
Procarbazine MAO Inhibitors like procarbazine may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
Rasagiline MAO Inhibitors like rasagiline may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
Selegiline MAO Inhibitors like selegiline may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
Tranylcypromine The MAO inhibitor, Tranylcypromine, may increase the vasopressor effect of the alpha2-agonist, Brimonidine. Concomitant therapy is contraindicated.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Food Interactions Not Available

Targets


Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action yes
Actions agonist
References
  • Rauly I, Ailhaud M, Wurch T, Pauwels PJ: alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway. Biochem Pharmacol. 2000 Jun 15;59(12):1531-8. - Pubmed
  • Wikberg-Matsson A, Simonsen U: Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries. Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2049-55. - Pubmed
  • Meana JJ, Barturen F, Garro MA, Garcia-Sevilla JA, Fontan A, Zarranz JJ: Decreased density of presynaptic alpha 2-adrenoceptors in postmortem brains of patients with Alzheimer's disease. J Neurochem. 1992 May;58(5):1896-904. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4223
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action yes
Actions agonist
References
  • Trendelenburg AU, Philipp M, Meyer A, Klebroff W, Hein L, Starke K: All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):504-12. Epub 2003 Nov 11. - Pubmed
  • Bohmann C, Schollmeyer P, Rump LC: Methoxamine inhibits noradrenaline release through activation of alpha 1- and alpha 2-adrenoceptors in rat isolated kidney: involvement of purines and prostaglandins. Naunyn Schmiedebergs Arch Pharmacol. 1993 Mar;347(3):273-9. - Pubmed
DTHybrid score 0.2923
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action yes
Actions agonist
References
  • Trendelenburg AU, Philipp M, Meyer A, Klebroff W, Hein L, Starke K: All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):504-12. Epub 2003 Nov 11. - Pubmed
  • Orito K, Kishi M, Imaizumi T, Nakazawa T, Hashimoto A, Mori T, Kambe T: alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. Br J Pharmacol. 2001 Oct;134(4):763-70. - Pubmed
  • Zhang W, Ordway GA: The alpha2C-adrenoceptor modulates GABA release in mouse striatum. Brain Res Mol Brain Res. 2003 Apr 10;112(1-2):24-32. - Pubmed
  • Prinster SC, Holmqvist TG, Hall RA: Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors. J Pharmacol Exp Ther. 2006 Sep;318(3):974-81. Epub 2006 Jun 6. - Pubmed
DTHybrid score 0.2918

Enzymes


Aldehyde oxidase
Name Aldehyde oxidase
Gene Name AOX1
Actions substrate
References
  • -
  • Acheampong AA, Chien DS, Lam S, Vekich S, Breau A, Usansky J, Harcourt D, Munk SA, Nguyen H, Garst M, Tang-Liu D: Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase. Xenobiotica. 1996 Oct;26(10):1035-55. - Pubmed
DTHybrid score 0.2526

Predictions


Id Partner name Gene Name Score
556 Alpha-1A adrenergic receptor ADRA1A 0.1549
4512 Cytochrome P450 3A4 CYP3A4 0.1066
23 D(1A) dopamine receptor DRD1 0.106
502 5-hydroxytryptamine 2A receptor HTR2A 0.0987
320 5-hydroxytryptamine 1A receptor HTR1A 0.0937
831 D(2) dopamine receptor DRD2 0.0904
163 D(1B) dopamine receptor DRD5 0.0878
590 5-hydroxytryptamine 2C receptor HTR2C 0.0864
632 Alpha-1B adrenergic receptor ADRA1B 0.086
638 D(3) dopamine receptor DRD3 0.0853
725 5-hydroxytryptamine 1D receptor HTR1D 0.0812
432 D(4) dopamine receptor DRD4 0.0801
4200 Cytochrome P450 1A2 CYP1A2 0.0758
885 5-hydroxytryptamine 1B receptor HTR1B 0.0733
4119 Cytochrome P450 2D6 CYP2D6 0.0685
789 Alpha-1D adrenergic receptor ADRA1D 0.0629
436 5-hydroxytryptamine 2B receptor HTR2B 0.0538
716 5-hydroxytryptamine 7 receptor HTR7 0.048
3947 Xanthine dehydrogenase/oxidase XDH 0.0474
492 Histamine H1 receptor HRH1 0.0461
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0424
766 Beta-2 adrenergic receptor ADRB2 0.0419
6070 Nischarin NISCH 0.0397
193 Beta-1 adrenergic receptor ADRB1 0.0363
2353 Apolipoprotein(a) LPA 0.0343
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.034
6147 Solute carrier family 22 member 3 SLC22A3 0.0325
824 Sodium-dependent serotonin transporter SLC6A4 0.0314
1588 Multidrug resistance protein 1 ABCB1 0.0312
4118 Cytochrome P450 3A5 CYP3A5 0.0306
234 Plasminogen PLG 0.0306
723 Cytosolic phospholipase A2 PLA2G4A 0.0304
6145 Solute carrier family 22 member 1 SLC22A1 0.0293
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.029
1792 Tissue-type plasminogen activator PLAT 0.0268
1517 Beta-3 adrenergic receptor ADRB3 0.0265
713 Sodium-dependent dopamine transporter SLC6A3 0.0263
1256 5-hydroxytryptamine 6 receptor HTR6 0.0263
1757 Myeloperoxidase MPO 0.0258
131 Synaptic vesicular amine transporter SLC18A2 0.0256
3941 Amine oxidase [flavin-containing] A MAOA 0.0253
338 DNA polymerase UL30 0.0246
379 DNA polymerase UL54 0.0246
697 DNA polymerase ORF28 0.0246
2482 DNA polymerase 43 0.0246
4104 DNA polymerase BALF5 0.0246
6144 Solute carrier family 22 member 2 SLC22A2 0.0244
6142 Solute carrier family 22 member 8 SLC22A8 0.023
6107 Cytochrome P450 3A7 CYP3A7 0.0228
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0223
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0217
828 Phenylalanine-4-hydroxylase PAH 0.0211
3109 Phenylalanine-4-hydroxylase phhA 0.0211
118 Organic cation/carnitine transporter 2 SLC22A5 0.0203
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0201
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0195
528 5-hydroxytryptamine 1E receptor HTR1E 0.0194
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0193
3939 Amine oxidase [flavin-containing] B MAOB 0.0192
617 Muscarinic acetylcholine receptor M2 CHRM2 0.019
6143 Solute carrier family 22 member 7 SLC22A7 0.0189
341 5-hydroxytryptamine 3 receptor HTR3A 0.0175
3811 Cytochrome P450 19A1 CYP19A1 0.0147
6016 Cytochrome P450 2C19 CYP2C19 0.0145
4757 Cytochrome P450 2C9 CYP2C9 0.0143
811 Translocator protein TSPO 0.0137
6024 Cytochrome P450 1A1 CYP1A1 0.0136
6030 Cytochrome P450 2B6 CYP2B6 0.0136
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0134
6013 Cytochrome P450 2E1 CYP2E1 0.0127
124 Histamine H2 receptor HRH2 0.0112
1636 Trace amine-associated receptor 1 TAAR1 0.011
1405 Thiopurine S-methyltransferase TPMT 0.0108
6171 Solute carrier family 28 member 3 SLC28A3 0.0107
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0105
4924 Cytochrome P450 2C8 CYP2C8 0.0104
869 Estrogen receptor beta ESR2 0.0103
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0099
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0097
465 Calmodulin CALM1 0.0097
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0097
2164 Multidrug resistance-associated protein 4 ABCC4 0.0096
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0091
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
6136 Multidrug resistance-associated protein 5 ABCC5 0.0089
136 Estrogen receptor ESR1 0.0088
3810 Catechol O-methyltransferase COMT 0.0083
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0082
400 Coagulation factor IX F9 0.0079
5461 Coagulation factor IX F9 0.0079
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0077
3917 Methylenetetrahydrofolate reductase MTHFR 0.0075
587 Serum albumin ALB 0.0073
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0073
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0073
604 Vitamin K-dependent protein Z PROZ 0.0073
233 Potassium channel subfamily K member 2 KCNK2 0.0072
833 Organic cation/carnitine transporter 1 SLC22A4 0.0069
422 Vitamin K-dependent protein C PROC 0.0066
1245 Vitamin K-dependent protein S PROS1 0.0066
6151 Monocarboxylate transporter 10 SLC16A10 0.0066
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0064
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0063
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0063
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0061
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0061
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0061
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0059
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0059
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0057
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0056
798 Osteocalcin BGLAP 0.0053
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0049
5818 Folate receptor alpha FOLR1 0.0049
5718 Cytochrome P450 2A6 CYP2A6 0.0049
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0048
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0048
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0048
369 Coagulation factor VII F7 0.0048
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0047
3426 Glutamine synthetase glnA 0.0047
3987 Glutamine synthetase GLUL 0.0047
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0046
3923 Cholinesterase BCHE 0.0046
6128 Carbonic anhydrase-related protein 10 CA10 0.0044
6133 Sodium channel subunit beta-2 SCN2B 0.0044
6134 Sodium channel subunit beta-3 SCN3B 0.0044
6132 Sodium channel subunit beta-1 SCN1B 0.0044
6135 Sodium channel subunit beta-4 SCN4B 0.0044
6129 Carbonic anhydrase-related protein 11 CA11 0.0044
6127 Carbonic anhydrase-related protein CA8 0.0044
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0044
293 Gamma-glutamyl hydrolase GGH 0.0043
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0042
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.004
164 Histamine H4 receptor HRH4 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0038
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0038
6130 Carbonic anhydrase 13 CA13 0.0038
4120 NADPH--cytochrome P450 reductase POR 0.0037
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0037
1650 Heme carrier protein 1 SLC46A1 0.0037
6131 Carbonic anhydrase 14 CA14 0.0037
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0036
239 Coagulation factor X F10 0.0035
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
6122 Carbonic anhydrase 3 CA3 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0032
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0032
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0031
3007 Carbonic anhydrase 12 CA12 0.0031
4205 Carbonic anhydrase 9 CA9 0.0031
365 Dihydrofolate reductase DHFR 0.003
2381 Dihydrofolate reductase DFR1 0.003
2833 Dihydrofolate reductase Not Available 0.003
2931 Dihydrofolate reductase folA 0.003
3544 Dihydrofolate reductase folA 0.003
3682 Dihydrofolate reductase folA 0.003
6642 Dihydrofolate reductase folA 0.003
6756 Dihydrofolate reductase dfrA 0.003
6126 Carbonic anhydrase 7 CA7 0.0029
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
54 Prothrombin F2 0.0029
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0029
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0029
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0027
6148 Multidrug resistance-associated protein 7 ABCC10 0.0027
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0026
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0026
24 Thymidylate synthase TMP1 0.0026
359 Thymidylate synthase TYMS 0.0026
2626 Thymidylate synthase thyA 0.0026
2729 Thymidylate synthase thyA 0.0026
5352 Thymidylate synthase THYA 0.0026
696 Kappa-type opioid receptor OPRK1 0.0026
738 Monocarboxylate transporter 1 SLC16A1 0.0025
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0024
592 Carbonic anhydrase 4 CA4 0.0024
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0023
1898 Cytochrome P450 1B1 CYP1B1 0.0023
1024 Solute carrier family 22 member 11 SLC22A11 0.0022
295 Carbonic anhydrase 1 CA1 0.0022
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0021
1656 CYP2B protein CYP2B 0.0021
862 Multidrug resistance-associated protein 1 ABCC1 0.0021
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.002
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.002
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0019
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0019
1729 Solute carrier family 22 member 6 SLC22A6 0.0018
357 Carbonic anhydrase 2 CA2 0.0017
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0013
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
816 Biliverdin reductase A BLVRA 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
1618 High affinity nerve growth factor receptor NTRK1 0.001
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.001
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.001
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.001
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.001
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.001
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.001
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.001
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.001
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.001
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.001
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.001
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.001
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.001
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.001
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.001
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.001
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.001
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.001
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.001
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.001
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.001
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.001
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.001
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.001
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.001
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.0009
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0009
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0009
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0009
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0009
328 Sorbitol dehydrogenase SORD 0.0009
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0009
597 Dihydropteridine reductase QDPR 0.0009
396 Alcohol dehydrogenase 4 ADH4 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0009
666 NADP-dependent malic enzyme ME1 0.0009
6026 Alcohol dehydrogenase 6 ADH6 0.0008
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0008
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0008
857 Malate dehydrogenase, mitochondrial MDH2 0.0008
77 L-lactate dehydrogenase B chain LDHB 0.0008
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0008
12 Alcohol dehydrogenase class 3 ADH5 0.0008
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0008
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0008
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0008
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0008
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0008
626 Cysteine dioxygenase type 1 CDO1 0.0008
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0008
627 11-cis retinol dehydrogenase RDH5 0.0008
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0008
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0008
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0008
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0008
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0008
13 Aminomethyltransferase, mitochondrial AMT 0.0008
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0007
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0007
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0007
279 Tyrosinase TYR 0.0007
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
654 Flavin reductase BLVRB 0.0007
467 Delta-type opioid receptor OPRD1 0.0007
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
380 Cytochrome P450 17A1 CYP17A1 0.0006
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0006
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0006
714 Glutathione reductase, mitochondrial GSR 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
468 Cytochrome P450 4A11 CYP4A11 0.0006
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0006
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0005
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0005
822 Aldose reductase AKR1B1 0.0005
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