DT-Web: DB00472

Identification

Name

Fluoxetine

Accession Number

DB00472 (APRD00530)

Type

small molecule

Description

Fluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D₂ or histamine H₁ receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT_1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT_1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Fluoxetine may be used to treat major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and in combination with olanzapine for treatment-resistant or bipolar I depression. Fluoxetine is the most anorexic and stimulating SSRI.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

309.3261

Groups

approved

Monoisotopic Weight

309.134048818

Pharmacology

Indication

Labeled indication include: major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and combination treatment with olanzapine for treatment-resistant or bipolar I depression. Unlabeled indications include: selective mutism, mild dementia-associated agitation in nonpsychotic patients, post-traumatic stress disorder (PTSD), social anxiety disorder, chronic neuropathic pain, fibromyalgia, and Raynaud's phenomenon.

Mechanism of action

Metabolized to norfluoxetine, fluoxetine is a selective serotonin-reuptake inhibitor (SSRI), it blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT_1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

Absorption

Well absorbed from the GI tract following oral administration. Oral bioavailability is estimated to be at least 60-80%. Peak plasma concentrations occur within 6-8 hours following a single oral administration of a 40 mg dose. The oral solution and delayed-release capsule are bioequivalent. Food does not affect the systemic bioavailability of fluoxetine but it delays the absorption by 1-2 hours (not clinically significant). Prozac Weekly capsules, a delayed-release formulation, contain enteric-coated pellets that resist dissolution until reaching a segment of the gastrointestinal tract where the pH exceeds 5.5. The enteric coating delays the onset of absorption of fluoxetine 1 to 2 hours relative to the immediate-release formulations.

Protein binding

94.5% bound to human serum proteins, including albumin and alpha-1-glycoprotein.

Biotransformation

Limited data from animal studies suggest that fluoxetine may undergo first-pass metabolism may occur via the liver and/or lungs. Fluoxetine appears to be extensively metabolized, likely in the liver, to norfluoxetine and other metabolites. Norfluoxetine, the principal active metabolite, is formed via N-demethylation of fluoxetine. Norfluoxetine appears to be comparable pharmacologic potency as fluoxetine. Fluoxetine and norfluoxetine both undergo phase II glucuronidation reactions in the liver. It is also thought that fluoxetine and norfluoxetine undergo O-dealkylation to form p-trifluoromethylphenol, which is then subsequently metabolized to hippuric acid.

Route of elimination

The primary route of elimination appears to be hepatic metabolism to inactive metabolites excreted by the kidney. The S-enantiomer is eliminated more slowly and is the predominant enantiomer present at steady state.

Toxicity

Symptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. LD₅₀=284mg/kg (orally in mice). The most frequent side effects include: nervous system effects such as anxiety, nervousness, insomnia, drowsiness, fatigue or asthenia, tremor, and dizziness or lightheadedness; GI effects such as anorexia, nausea, and diarrhea; vasodilation; dry mouth; abnormal vision; decreased libido; abnormal ejaculation; rash; and sweating. Withdrawal symptoms include flu-like symptoms, insomnia, nausea, imbalance, sensory changes and hyperactivity.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	The SSRI, fluoxetine, increases the effect of anticoagulant, acenocoumarol.
Almotriptan	Increased risk of CNS adverse effects
Amitriptyline	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of amitriptyline if fluoxetine is initiated, discontinued or dose changed.
Amoxapine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, amoxapine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of amoxapine if fluoxetine is initiated, discontinued or dose changed.
Amphetamine	Risk of serotoninergic syndrome
Anisindione	The SSRI, fluoxetine, increases the effect of anticoagulant, anisindione.
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Astemizole	Increased risk of cardiotoxicity and arrhythmias
Atomoxetine	The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Benzphetamine	Amphetamines may enhance the adverse/toxic effect of Serotonin Modulators. The risk of serotonin syndrome may be increased. Monitor patients closely for signs and symptoms of serotonin syndrome (e.g., agitation, tremor, tachycardia, etc.) when using amphetamines and serotonin modulators in combination.
Carbamazepine	Carbamazepine may decrease the serum concentration of fluoxetine by increasing its metabolism. Fluoxetine may increase the serum concentration of carbamazepine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or doses are changed.
Carvedilol	The SSRI, fluoxetine, may increase the bradycardic effect of the beta-blocker, carvedilol.
Cilostazol	Fluoxetine, a moderate CYP2C19 inhibitor, may decrease the metabolism of cilostazol. Monitor for changes in the therapeutic and adverse effects of cilostazol if fluoxetine is initiated, discontinued or dose changed.
Clarithromycin	Possible serotoninergic syndrome with this combination
Clomipramine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of clomipramine if fluoxetine is initiated, discontinued or dose changed.
Clozapine	The antidepressant increases the effect of clozapine
Cyclosporine	The antidepressant increases the effect and toxicity of cyclosporine
Cyproheptadine	Possible antagonism of action
Desipramine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of desipramine if fluoxetine is initiated, discontinued or dose changed.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dexfenfluramine	Risk of serotoninergic syndrome
Dextroamphetamine	Risk of serotoninergic syndrome
Dextromethorphan	Combination associated with possible serotoninergic syndrome
Dicumarol	The SSRI, fluoxetine, increases the effect of anticoagulant, dicumarol.
Diethylpropion	Risk of serotoninergic syndrome
Dihydroergotamine	Possible ergotism and severe ischemia with this combination
Doxepin	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of doxepin if fluoxetine is initiated, discontinued or dose changed.
Eletriptan	Increased risk of CNS adverse effects
Ergotamine	Possible ergotism and severe ischemia with this combination
Erythromycin	Possible serotoninergic syndrome with this combination
Ethotoin	Fluoxetine increases the effect of phenytoin
Fenfluramine	Risk of serotoninergic syndrome
Fosphenytoin	Fluoxetine increases the effect of phenytoin
Frovatriptan	Increased risk of CNS adverse effects
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Iloperidone	Fluoxetine is a strong CYP2D6 inhibitor that increases serum concentration of iloperidone. Reduce dose of iloperidone by 50%
Imipramine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of imipramine if fluoxetine is initiated, discontinued or dose changed.
Insulin Lispro	Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Isocarboxazid	Possible severe adverse reaction with this combination
Josamycin	Possible serotoninergic syndrome with this combination
Ketoprofen	Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Linezolid	Linezolide, a MAO inhibitor, may increase the serotonergic effect of fluoxetine, a SSRI. Increased for of serotonin syndrome. Concomitant therapy should be avoided.
Lithium	The SSRI, fluoxetine, increases serum levels of lithium.
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mazindol	Risk of serotoninergic syndrome
Mephenytoin	Fluoxetine increases the effect of phenytoin
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Methamphetamine	Risk of serotoninergic syndrome
Metoprolol	The SSRI, fluoxetine, may increase the bradycardic effect of the beta-blocker, metoprolol.
Moclobemide	Risk of serotoninergic syndrome
Naratriptan	Increased risk of CNS adverse effects
Nortriptyline	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of nortriptyline if fluoxetine is initiated, discontinued or dose changed.
Oxycodone	Increased risk of serotonin syndrome
Phendimetrazine	Risk of serotoninergic syndrome
Phenelzine	Possible severe adverse reaction with this combination
Phentermine	Risk of serotoninergic syndrome
Phenylpropanolamine	Risk of serotoninergic syndrome
Phenytoin	Fluoxetine increases the effect of phenytoin
Propafenone	Additive QTc-prolongation may occur increasing the risk of serious life-threatening arrhythmias. Fluoxetine may also increase the serum concentration of propafenone. Use caution during concomitant therapy and monitor for QTc-prolongation.
Propranolol	The SSRI, fluoxetine, may increase the bradycardic effect of the beta-blocker, propranolol.
Protriptyline	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of protriptyline if fluoxetine is initiated, discontinued or dose changed.
Rasagiline	Possible severe adverse reaction with this combination
Risperidone	The SSRI, fluoxetine, increases the effect and toxicity of risperidone.
Ritonavir	Increased risk of serotonin syndrome
Rizatriptan	Increased risk of CNS adverse effects
Selegiline	Possible severe adverse reaction with this combination
Sibutramine	Risk of serotoninergic syndrome
St. John's Wort	St. John's Wort increases the effect and toxicity of the SSRI, fluoxetine.
Sumatriptan	Increased risk of CNS adverse effects
Tacrine	The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by Fluoxetine, a CYP1A2 inhibitors. Monitor the efficacy and toxicity of Tacrine if Fluoxetine is initiated, discontinued or if the dose is changed.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tamoxifen	Fluoxetine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin	Fluoxetine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Fluoxetine is initiated, discontinued, or dose changed.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Fluoxetine. Consider alternate therapy or monitor for therapeutic/adverse effects of Fluoxetine if Terbinafine is initiated, discontinued or dose changed.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Tetrabenazine	Strong CYP2D6 inhibitors may increase exposure of the metabolites of tetrabenazine. Consider a reduction of dose.
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tiaprofenic acid	Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
Tipranavir	Tipranavir increases the concentration of Fluoxetine. The Fluoxetine dose may require an adjustment.
Tizanidine	Fluoxetine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Tolbutamide	Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Fluoxetine. Consider alternate therapy or monitor for changes in Fluoxetine therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Tolmetin	Increased antiplatelet effects may enhance the risk of bleeding. Alternate therapy may be considered or monitor for inreased bleeding during concomitant therapy.
Tolterodine	Fluoxetine may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	The use of two serotonin modulators, such as fluoxetine and tramadol, may increase the risk of serotonin syndrome. Fluoxetine may decrease the effect of tramadol by decreasing active metabolite production.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Treprostinil	The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Fluoxetine. Monitor for increased bleeding during concomitant thearpy.
Trimipramine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, trimipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Additive QTc-prolongation may also occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used cautiously.
Triprolidine	The CNS depressants, Triprolidine and Fluoxetine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Troleandomycin	Possible serotoninergic syndrome with this combination
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Warfarin	The SSRI, fluoxetine, increases the effect of anticoagulant, warfarin.
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and fluoxetine, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). Fluoxetine, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if fluoxetine is initiated, discontinued or dose changed.

Food Interactions

Take with food to reduce irritation and nausea.
Avoid alcohol.

Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Richman A, Heinrichs SC: Seizure prophylaxis in an animal model of epilepsy by dietary fluoxetine supplementation. Epilepsy Res. 2007 Apr;74(1):19-27. Epub 2007 Jan 9. - Pubmed Iceta R, Mesonero JE, Alcalde AI: Effect of long-term fluoxetine treatment on the human serotonin transporter in Caco-2 cells. Life Sci. 2007 Mar 27;80(16):1517-24. Epub 2007 Jan 20. - Pubmed Mirza NR, Nielsen EO, Troelsen KB: Serotonin transporter density and anxiolytic-like effects of antidepressants in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):858-66. Epub 2007 Jan 30. - Pubmed Sanders AC, Hussain AJ, Hen R, Zhuang X: Chronic Blockade or Constitutive Deletion of the Serotonin Transporter Reduces Operant Responding for Food Reward. Neuropsychopharmacology. 2007 Mar 14;. - Pubmed Goren MZ, Kucukibrahimoglu E, Berkman K, Terzioglu B: Fluoxetine partly exerts its actions through GABA: a neurochemical evidence. Neurochem Res. 2007 Sep;32(9):1559-65. Epub 2007 May 8. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score	0.3392

Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.563
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Urichuk L, Prior TI, Dursun S, Baker G: Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. Curr Drug Metab. 2008 Jun;9(5):410-8. - Pubmed Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. - Pubmed Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed Rasmussen BB, Brosen K: Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors? Ther Drug Monit. 2000 Apr;22(2):143-54. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7001
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.61
CYP2B protein
Name	CYP2B protein
Gene Name	CYP2B
Actions	inhibitor
References	Haduch A, Wojcikowski J, Daniel WA: Effect of selected antidepressant drugs on cytochrome P450 2B (CYP2B) in rat liver. An in vitro and in vivo study. Pharmacol Rep. 2008 Nov-Dec;60(6):957-65. - Pubmed
DTHybrid score	0.26
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5563
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed DeVane CL, Donovan JL, Liston HL, Markowitz JS, Cheng KT, Risch SC, Willard L: Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers. J Clin Psychopharmacol. 2004 Feb;24(1):4-10. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.9233
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Margolis JM, O'Donnell JP, Mankowski DC, Ekins S, Obach RS: (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91. - Pubmed
DTHybrid score	0.4118
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Margolis JM, O'Donnell JP, Mankowski DC, Ekins S, Obach RS: (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91. - Pubmed
DTHybrid score	0.4309

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. - Pubmed
DTHybrid score	0.5748

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.5748

Id	Partner name	Gene Name	Score
4924	Cytochrome P450 2C8	CYP2C8	0.3434
6107	Cytochrome P450 3A7	CYP3A7	0.2789
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.2237
6013	Cytochrome P450 2E1	CYP2E1	0.2109
6024	Cytochrome P450 1A1	CYP1A1	0.1676
492	Histamine H1 receptor	HRH1	0.1631
713	Sodium-dependent dopamine transporter	SLC6A3	0.1535
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1458
5718	Cytochrome P450 2A6	CYP2A6	0.1384
103	Muscarinic acetylcholine receptor M1	CHRM1	0.1237
20	Prostaglandin G/H synthase 1	PTGS1	0.1236
556	Alpha-1A adrenergic receptor	ADRA1A	0.116
502	5-hydroxytryptamine 2A receptor	HTR2A	0.1123
290	Prostaglandin G/H synthase 2	PTGS2	0.0935
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.091
6106	Cytochrome P450 2C18	CYP2C18	0.0905
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0896
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0891
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0862
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0851
862	Multidrug resistance-associated protein 1	ABCC1	0.0848
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0845
318	Alpha-2A adrenergic receptor	ADRA2A	0.084
3941	Amine oxidase [flavin-containing] A	MAOA	0.0836
6145	Solute carrier family 22 member 1	SLC22A1	0.0816
3811	Cytochrome P450 19A1	CYP19A1	0.081
831	D(2) dopamine receptor	DRD2	0.0798
1729	Solute carrier family 22 member 6	SLC22A6	0.0769
3939	Amine oxidase [flavin-containing] B	MAOB	0.0692
632	Alpha-1B adrenergic receptor	ADRA1B	0.0691
6144	Solute carrier family 22 member 2	SLC22A2	0.0674
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0626
766	Beta-2 adrenergic receptor	ADRB2	0.0612
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0607
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0597
193	Beta-1 adrenergic receptor	ADRB1	0.0582
3923	Cholinesterase	BCHE	0.057
23	D(1A) dopamine receptor	DRD1	0.0557
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0555
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0545
1898	Cytochrome P450 1B1	CYP1B1	0.0542
847	Mu-type opioid receptor	OPRM1	0.0538
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0531
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0512
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0512
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0499
118	Organic cation/carnitine transporter 2	SLC22A5	0.0485
6142	Solute carrier family 22 member 8	SLC22A8	0.0477
789	Alpha-1D adrenergic receptor	ADRA1D	0.047
776	Bile salt export pump	ABCB11	0.0453
731	HIV-1 protease	HIV-1 protease	0.0452
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0432
696	Kappa-type opioid receptor	OPRK1	0.0431
2164	Multidrug resistance-associated protein 4	ABCC4	0.0425
136	Estrogen receptor	ESR1	0.042
467	Delta-type opioid receptor	OPRD1	0.0419
465	Calmodulin	CALM1	0.041
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0404
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0396
871	Glucocorticoid receptor	NR3C1	0.0395
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0391
891	Dihydropteroate synthase	folP	0.0389
5359	Dihydropteroate synthase	folP	0.0389
7175	Dihydropteroate synthase	sulI	0.0389
6143	Solute carrier family 22 member 7	SLC22A7	0.0388
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0388
3947	Xanthine dehydrogenase/oxidase	XDH	0.0386
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0359
6147	Solute carrier family 22 member 3	SLC22A3	0.0355
260	Cytochrome P450 51	ERG11	0.0348
761	Cytochrome P450 51	ERG11	0.0348
3163	Cytochrome P450 51	cyp51	0.0348
629	Alpha-2B adrenergic receptor	ADRA2B	0.0344
844	Epidermal growth factor receptor	EGFR	0.0343
817	DNA topoisomerase 2-alpha	TOP2A	0.0335
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0333
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.033
36	Insulin receptor	INSR	0.0325
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0321
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.031
122	P2Y purinoceptor 12	P2RY12	0.0309
638	D(3) dopamine receptor	DRD3	0.0308
6182	Cytochrome P450 2J2	CYP2J2	0.0307
6031	Cytochrome P450 3A43	CYP3A43	0.0301
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0301
833	Organic cation/carnitine transporter 1	SLC22A4	0.03
131	Synaptic vesicular amine transporter	SLC18A2	0.03
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0295
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0295
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0294
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0294
378	Alpha-2C adrenergic receptor	ADRA2C	0.0293
468	Cytochrome P450 4A11	CYP4A11	0.0292
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0275
1024	Solute carrier family 22 member 11	SLC22A11	0.0273
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0269
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0265
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0263
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0263
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0263
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0259
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0258
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0257
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.025
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0246
146	Androgen receptor	AR	0.0243
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0239
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0237
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0232
4604	Liver carboxylesterase 1	CES1	0.023
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0223
756	Sex hormone-binding globulin	SHBG	0.0218
124	Histamine H2 receptor	HRH2	0.0217
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0216
504	Mast/stem cell growth factor receptor	KIT	0.0212
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0211
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0209
432	D(4) dopamine receptor	DRD4	0.0209
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0208
6148	Multidrug resistance-associated protein 7	ABCC10	0.0207
70	Type-1 angiotensin II receptor	AGTR1	0.0206
477	DNA topoisomerase 4 subunit A	parC	0.0205
886	DNA topoisomerase 4 subunit A	parC	0.0205
6226	DNA topoisomerase 4 subunit A	parC	0.0205
380	Cytochrome P450 17A1	CYP17A1	0.0204
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0203
614	Progesterone receptor	PGR	0.0203
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0202
404	DNA gyrase subunit A	gyrA	0.0202
6224	DNA gyrase subunit A	gyrA	0.0202
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0201
1517	Beta-3 adrenergic receptor	ADRB3	0.02
6220	Aryl hydrocarbon receptor	AHR	0.0195
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0192
6137	Multidrug resistance-associated protein 6	ABCC6	0.0191
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0191
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.019
6141	Sodium/bile acid cotransporter	SLC10A1	0.0187
705	Glutamate receptor 1	GRIA1	0.0186
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0183
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0182
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0178
474	Acetylcholinesterase	ACHE	0.0177
818	50S ribosomal protein L10	rplJ	0.0176
6432	Transporter	snf	0.0176
777	Tumor necrosis factor	TNF	0.0176
482	Glycine receptor subunit alpha-1	GLRA1	0.0173
1757	Myeloperoxidase	MPO	0.0172
6136	Multidrug resistance-associated protein 5	ABCC5	0.0172
4120	NADPH--cytochrome P450 reductase	POR	0.0171
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0171
811	Translocator protein	TSPO	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0169
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0169
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0169
94	5-hydroxytryptamine 4 receptor	HTR4	0.0168
716	5-hydroxytryptamine 7 receptor	HTR7	0.0168
183	Vascular endothelial growth factor A	VEGFA	0.0167
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0166
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0165
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0164
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0163
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0163
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0161
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0161
869	Estrogen receptor beta	ESR2	0.0161
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0161
407	Vascular endothelial growth factor receptor 2	KDR	0.0157
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0156
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0155
26	Vascular endothelial growth factor receptor 3	FLT4	0.0155
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0151
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0151
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0151
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.015
232	Corticosteroid-binding globulin	SERPINA6	0.015
738	Monocarboxylate transporter 1	SLC16A1	0.0149
161	Tubulin beta chain	TUBB	0.0149
312	Tubulin beta chain	TUB2	0.0149
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0148
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0148
174	Sigma 1-type opioid receptor	SIGMAR1	0.0148
373	Transthyretin	TTR	0.0148
32	Vascular endothelial growth factor receptor 1	FLT1	0.0148
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0147
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0146
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0146
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0146
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0146
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0144
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0144
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0144
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0144
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
163	D(1B) dopamine receptor	DRD5	0.0142
1618	High affinity nerve growth factor receptor	NTRK1	0.0141
537	ATP synthase delta chain, mitochondrial	ATP5D	0.014
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0136
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0135
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0134
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0134
1010	Cytochrome P450 51A1	CYP51A1	0.0133
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0132
768	FK506-binding protein 1A	FKBP1A	0.013
6085	Fatty acid-binding protein, intestinal	FABP2	0.0129
6014	Cytochrome P450 2A13	CYP2A13	0.0129
737	Mineralocorticoid receptor	NR3C2	0.0128
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0127
427	Substance-P receptor	TACR1	0.0127
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0127
952	Dipeptidyl peptidase 4	DPP4	0.0126
6102	Arylamine N-acetyltransferase 2	NAT2	0.0124
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0123
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0123
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0122
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0121
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0121
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0121
29	Tubulin beta-1 chain	TUBB1	0.0119
1050	Bile salt sulfotransferase	SULT2A1	0.0118
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0118
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0115
1178	Adenosine A2a receptor	ADORA2A	0.0114
5787	Angiopoietin-1 receptor	TEK	0.0113
16	Adenosine A1 receptor	ADORA1	0.011
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0108
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0107
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0107
319	Opioid receptor, sigma 1	OPRS1	0.0107
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0106
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0106
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0106
1192	Sulfotransferase 1A1	SULT1A1	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
295	Carbonic anhydrase 1	CA1	0.01
6020	Aldehyde oxidase	AOX1	0.01
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0099
365	Dihydrofolate reductase	DHFR	0.0098
2381	Dihydrofolate reductase	DFR1	0.0098
2833	Dihydrofolate reductase	Not Available	0.0098
2931	Dihydrofolate reductase	folA	0.0098
3544	Dihydrofolate reductase	folA	0.0098
3682	Dihydrofolate reductase	folA	0.0098
6642	Dihydrofolate reductase	folA	0.0098
6756	Dihydrofolate reductase	dfrA	0.0098
3932	Glutathione S-transferase A2	GSTA2	0.0098
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0098
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
592	Carbonic anhydrase 4	CA4	0.0097
904	Glutathione S-transferase P	GSTP1	0.0096
49	Endothelin B receptor	EDNRB	0.0096
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0095
566	Serotransferrin	TF	0.0094
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
244	Angiotensin-converting enzyme	ACE	0.0092
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.009
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.009
578	Endothelin-1 receptor	EDNRA	0.009
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.009
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.009
921	Glutamate receptor 2	GRIA2	0.009
1353	DNA topoisomerase 1	TOP1	0.0089
3552	DNA topoisomerase 1	topA	0.0089
273	Apoptosis regulator Bcl-2	BCL2	0.0089
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0087
4237	50S ribosomal protein L22	rplV	0.0087
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0086
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0086
275	Arachidonate 5-lipoxygenase	ALOX5	0.0085
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0085
2539	Tubulin alpha-1 chain	TUBA4A	0.0084
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0084
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0083
823	Fibroblast growth factor receptor 2	FGFR2	0.0083
239	Coagulation factor X	F10	0.0082
4122	Histone deacetylase 2	HDAC2	0.0082
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0082
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0082
780	Retinoic acid receptor RXR-gamma	RXRG	0.0082
357	Carbonic anhydrase 2	CA2	0.0082
565	Extracellular calcium-sensing receptor	CASR	0.008
2112	Toll-like receptor 9	TLR9	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.008
173	Toll-like receptor 7	TLR7	0.0079
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0078
459	Retinoic acid receptor RXR-alpha	RXRA	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0078
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0078
6043	Putative G-protein coupled receptor 44	GPR44	0.0078
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0078
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0077
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0077
4203	Histamine N-methyltransferase	HNMT	0.0076
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0076
2449	Tubulin alpha-3 chain	TUBA1A	0.0076
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0076
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0075
165	FL cytokine receptor	FLT3	0.0075
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0075
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0075
88	Retinoic acid receptor RXR-beta	RXRB	0.0075
3810	Catechol O-methyltransferase	COMT	0.0074
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0074
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0074
54	Prothrombin	F2	0.0074
4238	50S ribosomal protein L4	rplD	0.0074
5578	50S ribosomal protein L4	rplD	0.0074
6173	50S ribosomal protein L4	rplD	0.0074
6219	50S ribosomal protein L4	rplD	0.0074
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0074
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0074
558	Solute carrier family 12 member 1	SLC12A1	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
5300	Antigen peptide transporter 1	TAP1	0.0072
6138	Multidrug resistance protein 3	ABCB4	0.0072
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0072
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0071
284	DNA-directed RNA polymerase beta chain	rpoB	0.0071
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0071
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.007
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.007
24	Thymidylate synthase	TMP1	0.007
359	Thymidylate synthase	TYMS	0.007
2626	Thymidylate synthase	thyA	0.007
2729	Thymidylate synthase	thyA	0.007
5352	Thymidylate synthase	THYA	0.007
1864	RET proto-oncogene	RET	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0069
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0069
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0069
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0068
814	Ryanodine receptor 1	RYR1	0.0068
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
68	Cannabinoid receptor 1	CNR1	0.0068
563	Thyroid peroxidase	TPO	0.0067
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0067
723	Cytosolic phospholipase A2	PLA2G4A	0.0067
1629	Transcription factor AP-1	JUN	0.0067
153	Dopamine beta-hydroxylase	DBH	0.0067
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0066
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0066
33	Cystine/glutamate transporter	SLC7A11	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0065
1636	Trace amine-associated receptor 1	TAAR1	0.0064
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
856	Vitamin D3 receptor	VDR	0.0063
4311	tRNA	TRDMT1	0.0063
4325	tRNA	trmD	0.0063
4328	tRNA	trmD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
1852	Microtubule-associated protein 2	MAP2	0.0063
6044	Serum paraoxonase/lactonase 3	PON3	0.0063
133	Dihydropterate synthase	sulI	0.0063
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0063
1992	Vitamin D-binding protein	GC	0.0061
5934	Cytochrome P450 26A1	CYP26A1	0.006
6149	Solute carrier family 22 member 10	SLC22A10	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
6126	Carbonic anhydrase 7	CA7	0.006
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0059
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
84	Nuclear receptor 0B1	NR0B1	0.0057
518	Peroxidase/catalase T	katG	0.0057
4103	Proteasome subunit beta type 2	PSMB2	0.0057
4102	Proteasome subunit beta type 5	PSMB5	0.0056
4101	Proteasome subunit beta type 1	PSMB1	0.0056
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0056
6174	50S ribosomal protein L32	rpmF	0.0056
1630	Integrin beta-2	ITGB2	0.0056
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0056
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0055
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0055
6506	Stathmin-4	STMN4	0.0055
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0054
581	Cytochrome P450 2R1	CYP2R1	0.0054
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
469	Annexin A1	ANXA1	0.0054
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0053
594	Thyroxine-binding globulin	SERPINA7	0.0053
1275	Estrogen sulfotransferase	SULT1E1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0053
712	Tubulin alpha chain	TUB1	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
7	Nitric oxide synthase, inducible	NOS2	0.0051
65	Matrix metalloproteinase-9	Not Available	0.0051
6146	High affinity copper uptake protein 1	SLC31A1	0.0051
1525	Heparin-binding growth factor 2	FGF2	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
976	Platelet glycoprotein IX	GP9	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.005
2981	Phospholipase A2, membrane associated	PLA2G2A	0.005
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.005
162	Retinoic acid receptor gamma-1	RARG	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
751	Potassium channel subfamily K member 6	KCNK6	0.0049
758	Thyroid hormone receptor alpha	THRA	0.0049
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0049
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0048
3856	Fibroblast growth factor receptor 3	FGFR3	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
4773	Deoxycytidine kinase	DCK	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
936	Ephrin type-A receptor 2	EPHA2	0.0046
3086	Plasmepsin-2	Not Available	0.0046
634	Squalene monooxygenase	SQLE	0.0046
7196	Squalene monooxygenase	ERG1	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
172	Potassium channel subfamily K member 1	KCNK1	0.0045
1196	Complement decay-accelerating factor	CD55	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
346	Thyroid hormone receptor beta-1	THRB	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
707	72 kDa type IV collagenase	MMP2	0.0044
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0043
1483	Membrane copper amine oxidase	AOC3	0.0043
117	Sterol O-acyltransferase 1	SOAT1	0.0043
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0042
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0042
3809	Estrogen-related receptor gamma	ESRRG	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
3957	Adenosine deaminase	ADA	0.0042
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0042
6103	Arylamine N-acetyltransferase 1	NAT1	0.0042
1648	Elastin	ELN	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
4192	DNA topoisomerase 2-beta	TOP2B	0.0041
5923	Microtubule-associated protein tau	MAPT	0.0041
5924	Microtubule-associated protein 4	MAP4	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0041
106	Cannabinoid receptor 2	CNR2	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
3937	Fatty-acid amide hydrolase	FAAH	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
4161	Furin	FURIN	0.004
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.004
1714	Mitogen-activated protein kinase 3	MAPK3	0.004
1262	Corticotropin-lipotropin	POMC	0.004
1541	Metalloproteinase	mmp20	0.0039
2808	Chloramphenicol acetyltransferase 3	cat3	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
6677	Myelin P2 protein	PMP2	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0038
6824	Tyrosine-protein kinase Lyn	LYN	0.0038
908	Glutathione S-transferase theta-1	GSTT1	0.0038
233	Potassium channel subfamily K member 2	KCNK2	0.0038
85	Growth hormone receptor	GHR	0.0038
164	Histamine H4 receptor	HRH4	0.0038
3426	Glutamine synthetase	glnA	0.0037
3987	Glutamine synthetase	GLUL	0.0037
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0037
4217	Telomerase reverse transcriptase	TERT	0.0037
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0037
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0036
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0036
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0036
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0036
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0036
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0036
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0036
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0036
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0036
251	Alcohol dehydrogenase 1A	ADH1A	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
3601	Dihydropteroate synthase 1	folP1	0.0036
3807	Dihydropteroate synthase 1	folP1	0.0036
3808	Dihydropteroate synthase 2	folP2	0.0036
2417	Chloramphenicol acetyltransferase	cat	0.0036
3278	Chloramphenicol acetyltransferase	cat	0.0036
2207	Rhodopsin	RHO	0.0035
444	Alcohol dehydrogenase 1B	ADH1B	0.0035
4210	Toll-like receptor 4	TLR4	0.0035
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0035
2810	Dr hemagglutinin structural subunit	draA	0.0035
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
939	50S ribosomal protein L3	rplC	0.0035
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0035
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
229	Retinoic acid receptor beta	RARB	0.0034
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
820	Glycine receptor subunit alpha-2	GLRA2	0.0034
730	Retinoic acid receptor alpha	RARA	0.0033
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0033
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0033
1039	Histone deacetylase 9	HDAC9	0.0033
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0032
572	Integrin alpha-L	ITGAL	0.0032
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0032
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0032
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
3639	Thymidine phosphorylase	deoA	0.0032
3936	Thymidine phosphorylase	TYMP	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0032
1867	Major prion protein	PRNP	0.0032
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0032
1291	cAMP response element-binding protein	CREB1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
267	Plasminogen activator inhibitor 1	SERPINE1	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0031
199	Monocarboxylate transporter 8	SLC16A2	0.0031
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0031
1374	Natriuretic peptides B	NPPB	0.0031
1827	Gap junction alpha-1 protein	GJA1	0.0031
1908	Vascular cell adhesion protein 1	VCAM1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
291	Nitric-oxide synthase, endothelial	NOS3	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
5798	Mitogen-activated protein kinase 11	MAPK11	0.003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.003
517	Alcohol dehydrogenase 1C	ADH1C	0.003
1268	Neuropeptide S receptor	NPSR1	0.003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
6048	Troponin C, skeletal muscle	TNNC2	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
719	Retinoic acid receptor responder protein 1	RARRES1	0.0029
770	Retinoic acid-induced protein 3	GPRC5A	0.0029
2320	Thymidine kinase, cytosolic	TK1	0.0029
6033	High affinity interleukin-8 receptor A	CXCR1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
6221	Steroid hormone receptor ERR1	ESRRA	0.0029
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0028
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0028
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0028
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0028
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
2021	Thrombomodulin	THBD	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
6073	Potassium channel subfamily K member 9	KCNK9	0.0027
6072	Potassium channel subfamily K member 3	KCNK3	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
2216	Fibroblast growth factor receptor 4	FGFR4	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
4226	Uridine phosphorylase 2	UPP2	0.0026
3913	Glutamic acid decarboxylase	GAD65	0.0026
6218	Pannexin-1	PANX1	0.0025
569	Retinal dehydrogenase 2	ALDH1A2	0.0025
6859	Protein S100-A4	S100A4	0.0025
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
6151	Monocarboxylate transporter 10	SLC16A10	0.0025
3830	Calreticulin	CALR	0.0025
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0025
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0025
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0025
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
896	Glutathione S-transferase Mu 1	GSTM1	0.0025
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0025
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
611	Retinal dehydrogenase 1	ALDH1A1	0.0024
4225	Uridine phosphorylase 1	UPP1	0.0024
6231	Pepsin A	PGA3	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6459	Glycodelin	PAEP	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
6501	Fatty acid-binding protein, liver	FABP1	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
413	Amidophosphoribosyltransferase	PPAT	0.0022
2515	Amidophosphoribosyltransferase	purF	0.0022
3714	Amidophosphoribosyltransferase	purF	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
3904	Alanine aminotransferase 2	GPT2	0.0021
735	Alanine aminotransferase 1	GPT	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1650	Heme carrier protein 1	SLC46A1	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
6163	Copper-transporting ATPase 2	ATP7B	0.0021
6165	Copper-transporting ATPase 1	ATP7A	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
268	Adenosine A2b receptor	ADORA2B	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
489	Monocarboxylate transporter 2	SLC16A7	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6042	Prostaglandin reductase 2	PTGR2	0.002
283	SEC14-like protein 2	SEC14L2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6755	Poliovirus receptor	PVR	0.002
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.002
822	Aldose reductase	AKR1B1	0.002
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
1792	Tissue-type plasminogen activator	PLAT	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0017
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0017
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0017
6168	Solute carrier family 22 member 16	SLC22A16	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0016
6228	Nuclear receptor coactivator 1	NCOA1	0.0016
1243	Cathepsin D	CTSD	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
1313	Lactoylglutathione lyase	GLO1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
76	Nitric-oxide synthase, brain	NOS1	0.0014
3221	Cytochrome c4	cc4	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
4386	Hemoglobin-like protein HbN	glbN	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
2298	Cytochrome P450-cam	camC	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
4954	Soluble cytochrome b558	Not Available	0.0009
4943	Cytochrome c6	petJ	0.0009
4916	Cyanoglobin	glbN	0.0009
4925	Cytochrome c-type protein SHP	shp	0.0009
4947	Bacterial hemoglobin	vhb	0.0009
4994	Hemoglobin-like protein HbO	glbO	0.0009
4915	Cytochrome c-550	psbV	0.0009
4959	Cytochrome c-550	psbV	0.0009
5216	Cytochrome c-550	psbV	0.0009
4934	Cytochrome c-551	nirM	0.0009
5218	Cytochrome c-551	nirM	0.0009
4984	Neuroglobin	NGB	0.0009
4975	Cytochrome c-556	RPA3973	0.0009
5000	HemO	hemO	0.0009
4981	Iron-starvation protein PigA	pigA	0.0009
4905	Cytochrome c2	Not Available	0.0009
4939	Cytochrome c2	cycA	0.0009
4964	Cytochrome c2	cycA	0.0009
4979	Cytochrome c2	cycA	0.0009
6673	Cytochrome c2	cycA	0.0009
4942	Diheme cytochrome c napB	napB	0.0009
4910	Cytoglobin	CYGB	0.0009
4936	Cytochrome c2 iso-2	Not Available	0.0009
4998	Hemoglobin-like protein yjbI	yjbI	0.0009
4935	Cytochrome c-554	cycA1	0.0009
4909	CooA protein	cooA	0.0009
4907	Cytochrome c-L	moxG	0.0009
6865	Cytochrome c-L	moxG	0.0009
644	Heme oxygenase 2	HMOX2	0.0009
4982	Heme oxygenase 2	pbsA2	0.0009
4961	Hemophore HasA	hasA	0.0009
4971	Nonaheme cytochrome c	hmcA	0.0009
4904	Cytochrome c family protein	GSU1996	0.0009
4976	Apocytochrome f	petA	0.0009
6407	Apocytochrome f	petA	0.0009
4931	Cytochrome P450 167A1	CYP167A1	0.0009
4903	Methyl-accepting chemotaxis protein	Tar4	0.0009
4937	Cytochrome oxidase subunit II	rcoxA	0.0009
4764	Cytochrome P450 165C4	CYP165C4	0.0009
4972	P450cin	cinA	0.0009
4960	Putative cytochrome P450-family protein	SCO7417	0.0009
4989	Cytochrome c551 peroxidase	ccp	0.0009
5222	Cytochrome c551 peroxidase	ccpA	0.0009
4999	Cytochrome P450 165B3	CYP165B3	0.0009
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0009
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0009
4922	Cytochrome c, putative	SO_4144	0.0009
4993	Hydroxylamine oxidoreductase	hao1	0.0009
4952	Catalase/peroxidase	katA	0.0009
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0009
3093	Catalase HPII	katE	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
1507	Cytochrome c	CYCS	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
125	DNA polymerase beta	POLB	0.0007
4920	Peroxidase/catalase	katG	0.0007
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
3411	Cytochrome P450 121	cyp121	0.0006
3670	Soluble cytochrome b562 precursor	cybC	0.0006
3291	Cytochrome c-552	cycA	0.0006
4927	Cytochrome c-552	nrfA	0.0006
4938	Cytochrome c-552	cycA	0.0006
4953	Cytochrome c-552	nrfA	0.0006
5217	Cytochrome c-552	cycM	0.0006
2617	Nitric oxide synthase oxygenase	nos	0.0006
2701	Nitric oxide synthase oxygenase	nos	0.0006
3102	Flavohemoprotein	hmp	0.0006
4969	Flavohemoprotein	hmp	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
798	Osteocalcin	BGLAP	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4608	Putative cytochrome P450	SCO1207	0.0005
4963	Putative cytochrome P450	SCO2884	0.0005
6254	Putative cytochrome P450	SCO6998	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
358	Cystathionine beta-synthase	CBS	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00472 - Fluoxetine

Targets

Enzymes

Transporters

Carriers

Predictions