DT-Web

DB01124 - Tolbutamide


Identification
Name Tolbutamide
Accession Number DB01124 (APRD00267)
Type small molecule
Description Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating ? cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic ? cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Tolbutamide appears to be metabolized in the liver. Tolbutamide and its metabolites are excreted in urine (75-85%) and feces.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 270.348
Groups approved
Monoisotopic Weight 270.103813142
Pharmacology
Indication For treatment of NIDDM (non-insulin-dependent diabetes mellitus) in conjunction with diet and exercise.
Mechanism of action Sulfonylureas lower blood glucose in patients with NIDDM by directly stimulating the acute release of insulin from functioning beta cells of pancreatic islet tissue by an unknown process that involves a sulfonylurea receptor (receptor 1) on the beta cell. Sulfonylureas inhibit the ATP-potassium channels on the beta cell membrane and potassium efflux, which results in depolarization and calcium influx, calcium-calmodulin binding, kinase activation, and release of insulin-containing granules by exocytosis, an effect similar to that of glucose.
Absorption Readily absorbed following oral administration. Tolbutamide is detectable in plasma 30-60 minutes following oral administration of a single dose with peak plasma concentrations occurring within 3-5 hours. Absorption is unaltered if taken with food but is increased with high pH.
Protein binding Approximately 95% bound to plasma proteins.
Biotransformation Metabolized in the liver principally via oxidation of the p-methyl group producing the carboxyl metabolite, 1-butyl-3-p-carboxyphenylsulfonylurea. May also be metabolized to hydroxytolbutamide. Tolbutamide does not undergo acetylation like antibacterial sulfonamides as it does not have a p-amino group.
Route of elimination Unchanged drug and metabolites are eliminated in the urine and feces. Approximately 75-85% of a single orally administered dose is excreted in the urine principally as the 1-butyl-3-p-carboxyphenylsulfonylurea within 24 hours.
Toxicity Oral, mouse: LD50 = 2600 mg/kg
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Acebutolol may decrease symptoms of hypoglycemia and increase the time required for the body to compensate for hypoglycemia.
Acenocoumarol Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Acenocoumarol. Consider alternate therapy or monitor for changes in Acenocoumarol therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Acetylsalicylic acid Acetylsalicylic acid increases the effect of the sulfonylurea, tolbutamide.
Atenolol The beta-blocker, atenolol, may decrease symptoms of hypoglycemia.
Bisoprolol The beta-blocker, bisoprolol, may decrease symptoms of hypoglycemia.
Bosentan Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Bosentan. Consider alternate therapy or monitor for changes in Bosentan therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Capecitabine Capecitabine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Capecitabine is initiated, discontinued or dose changed.
Carvedilol The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Celecoxib Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Celecoxib. Consider alternate therapy or monitor for changes in Celecobix therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Chloramphenicol Chloramphenicol may increase the effect of sulfonylurea, tolbutamide.
Clofibrate Clofibrate may increase the effect of sulfonylurea, tolbutamide.
Dapsone Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Dapsone. Consider alternate therapy or monitor for changes in Dapsone therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Delavirdine Delavirdine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Delavirdine is initiated, discontinued or dose changed.
Digoxin Tolbutamide increases the effect of digoxin
Esmolol The beta-blocker, esmolol, may decrease symptoms of hypoglycemia.
Floxuridine Floxuridine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Floxuridine is initiated, discontinued or dose changed.
Fluconazole Fluconazole, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Fluconazole therapeutic and adverse effects if Delavirdine is initiated, discontinued or dose changed.
Fluorouracil Fluorouracil, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Fluorouracil is initiated, discontinued or dose changed.
Fluoxetine Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Fluoxetine. Consider alternate therapy or monitor for changes in Fluoxetine therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Flurbiprofen Flurbiprofen, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Flurbiprofen is initiated, discontinued or dose changed.
Fosphenytoin Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Fosphenytoin. Consider alternate therapy or monitor for changes in Fosphenytoin therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Gemfibrozil Gemfibrozil, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Gemfibrozil is initiated, discontinued or dose changed.
Glimepiride Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Glimepiride. Consider alternate therapy or monitor for changes in Glimepiride therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Glipizide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Glipizide. Consider alternate therapy or monitor for changes in Glipizide therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Ibuprofen Ibuprofen, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Ibuprofen is initiated, discontinued or dose changed.
Indomethacin Indomethacin, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Indomethacin is initiated, discontinued or dose changed.
Ketamine Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Ketamine. Consider alternate therapy or monitor for changes in Ketamine therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Ketoconazole Ketoconazole, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Ketoconazole is initiated, discontinued or dose changed.
Labetalol The beta-blocker, labetalol, may decrease symptoms of hypoglycemia.
Losartan Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Losartan. Consider alternate therapy or monitor for changes in Losartan therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Lumiracoxib Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Lumiracoxib. Consider alternate therapy or monitor for changes in Lumiracoxib therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Mefenamic acid Mefanamic acid, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Mefanamic acid is initiated, discontinued or dose changed.
Mestranol Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Mestranol. Consider alternate therapy or monitor for changes in Mestranol therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Metoprolol The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Miconazole Miconazole, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Miconazole is initiated, discontinued or dose changed.
Montelukast Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Montelukast. Consider alternate therapy or monitor for changes in Montelukast therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Nadolol The beta-blocker, nadolol, may decrease symptoms of hypoglycemia.
Nateglinide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Nateglinide. Consider alternate therapy or monitor for changes in Nateglinide therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Nicardipine Nicardipine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Nicardipine is initiated, discontinued or dose changed.
Oxprenolol The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Paclitaxel Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Paclitaxel. Consider alternate therapy or monitor for changes in Paclitaxel therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Phenylbutazone Phenylbutazone increases the effect of the hypoglycemic agent
Phenytoin Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Phenytoin. Consider alternate therapy or monitor for changes in Phenytoin therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Pindolol The beta-blocker, pindolol, may decrease symptoms of hypoglycemia.
Piroxicam Piroxicam, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Piroxicam is initiated, discontinued or dose changed.
Propranolol The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Rifampin Rifampin may decrease the effect of sulfonylurea, tolbutamide.
Sitaxentan Sitaxsentan, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Sitaxsentan is initiated, discontinued or dose changed.
Somatropin recombinant Somatropin may antagonize the hypoglycemic effect of Tolbutamide. Dose adjustments of Tolbutamide may be required.
Sulfadiazine Tolbutamide and Sulfadiazine are strong CYP2C9 inhibitors and substrates. Decreased metabolism and clearance of both agents may occur during concomitant therapy. Consider alternate therpy or monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose(s) changed.
Sulfamethoxazole Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Sulfamethoxazole. Consider alternate therapy or monitor for changes in Sulfamethoxazole therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Sulfinpyrazone Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Sulfinpyrazone. Consider alternate therapy or monitor for changes in Sulfinpyrazone therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Sulfisoxazole Tolbutamide and Sulfisoxazole are strong CYP2C9 inhibitors and substrates. Decreased metabolism and clearance of both agents may occur during concomitant therapy. Consider alternate therpy or monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose(s) changed.
Tamoxifen Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tamoxifen. Consider alternate therapy or monitor for changes in Tamoxifen therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Timolol The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Torasemide Tolbutamide, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Tolbutamide is initiated, discontinued or dose changed.
Trimethoprim The strong CYP2C9 inhibitor, Tolbutamide, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Tolbutamide is initiated, discontinued or dose changed.
Voriconazole Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Voriconazole. Consider alternate therapy or monitor for changes in Voriconazole therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Warfarin Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if tolbutamide is initiated, discontinued or dose changed.
Zafirlukast Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of zafirlukast. Consider alternate therapy or monitor for changes in zafirlukast therapeutic and adverse effects if tolbutamide is initiated, discontinued or dose changed.
Zopiclone Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Zopiclone. Consider alternate therapy or monitor for changes in Zopiclone therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


ATP-binding cassette transporter sub-family C member 8
Name ATP-binding cassette transporter sub-family C member 8
Gene Name ABCC8
Pharmacological action yes
Actions inhibitor
References
  • Mizuno CS, Chittiboyina AG, Kurtz TW, Pershadsingh HA, Avery MA: Type 2 diabetes and oral antihyperglycemic drugs. Curr Med Chem. 2008;15(1):61-74. - Pubmed
DTHybrid score 0.4752
ATP-sensitive inward rectifier potassium channel 1
Name ATP-sensitive inward rectifier potassium channel 1
Gene Name KCNJ1
Pharmacological action unknown
Actions inhibitor
References
  • Proks P, Jones P, Ashcroft FM: Interaction of stilbene disulphonates with cloned K(ATP) channels. Br J Pharmacol. 2001 Mar;132(5):973-82. - Pubmed
  • Smith PA, Proks P: Inhibition of the ATP-sensitive potassium channel from mouse pancreatic beta-cells by surfactants. Br J Pharmacol. 1998 Jun;124(3):529-39. - Pubmed
  • Liu X, Singh BB, Ambudkar IS: ATP-dependent activation of K(Ca) and ROMK-type K(ATP) channels in human submandibular gland ductal cells. J Biol Chem. 1999 Aug 27;274(35):25121-9. - Pubmed
DTHybrid score 0.675

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lasker JM, Wester MR, Aramsombatdee E, Raucy JL: Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch Biochem Biophys. 1998 May 1;353(1):16-28. - Pubmed
DTHybrid score 0.5326
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3589
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lasker JM, Wester MR, Aramsombatdee E, Raucy JL: Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch Biochem Biophys. 1998 May 1;353(1):16-28. - Pubmed
DTHybrid score 0.4214
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2205

Transporters


Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions inhibitor
References
  • Terada T, Sawada K, Saito H, Hashimoto Y, Inui K: Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. Eur J Pharmacol. 2000 Mar 24;392(1-2):11-7. - Pubmed
DTHybrid score 0.5707
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed
DTHybrid score 0.251
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Uwai Y, Saito H, Hashimoto Y, Inui K: Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1. Eur J Pharmacol. 2000 Jun 16;398(2):193-7. - Pubmed
DTHybrid score 0.3948
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Terada T, Sawada K, Saito H, Hashimoto Y, Inui K: Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. Eur J Pharmacol. 2000 Mar 24;392(1-2):11-7. - Pubmed
DTHybrid score 0.5476
Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions substrate
References
  • Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. Epub 2005 Jan 7. - Pubmed
DTHybrid score 0.2532

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.3533
1588 Multidrug resistance protein 1 ABCB1 0.2407
4119 Cytochrome P450 2D6 CYP2D6 0.2179
244 Angiotensin-converting enzyme ACE 0.1891
587 Serum albumin ALB 0.1837
4200 Cytochrome P450 1A2 CYP1A2 0.1794
20 Prostaglandin G/H synthase 1 PTGS1 0.1772
6142 Solute carrier family 22 member 8 SLC22A8 0.1591
4118 Cytochrome P450 3A5 CYP3A5 0.1487
6030 Cytochrome P450 2B6 CYP2B6 0.1403
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1276
118 Organic cation/carnitine transporter 2 SLC22A5 0.1273
633 Penicillin-binding proteins 1A/1B pbpA 0.1172
6107 Cytochrome P450 3A7 CYP3A7 0.1164
6013 Cytochrome P450 2E1 CYP2E1 0.1029
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0997
1024 Solute carrier family 22 member 11 SLC22A11 0.0974
5718 Cytochrome P450 2A6 CYP2A6 0.0898
6143 Solute carrier family 22 member 7 SLC22A7 0.0885
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0846
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0833
6024 Cytochrome P450 1A1 CYP1A1 0.0775
862 Multidrug resistance-associated protein 1 ABCC1 0.0766
290 Prostaglandin G/H synthase 2 PTGS2 0.0763
738 Monocarboxylate transporter 1 SLC16A1 0.0744
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0733
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0707
2164 Multidrug resistance-associated protein 4 ABCC4 0.0706
776 Bile salt export pump ABCB11 0.0684
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0673
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0669
6145 Solute carrier family 22 member 1 SLC22A1 0.0653
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0606
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0591
645 Penicillin-binding protein 1A mrcA 0.0513
5805 Penicillin-binding protein 1A ponA 0.0513
6185 Penicillin-binding protein 1A mrcA 0.0513
6799 Penicillin-binding protein 1A pbpA 0.0513
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0506
1 Peptidoglycan synthetase ftsI ftsI 0.0481
4155 Peptidoglycan synthetase ftsI ftsI 0.0481
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0451
6144 Solute carrier family 22 member 2 SLC22A2 0.045
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0449
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0448
6141 Sodium/bile acid cotransporter SLC10A1 0.044
318 Alpha-2A adrenergic receptor ADRA2A 0.0414
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0392
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0388
492 Histamine H1 receptor HRH1 0.0387
543 Penicillin-binding protein 1B mrcB 0.0385
6186 Penicillin-binding protein 1B ponB 0.0385
6822 Penicillin-binding protein 1b pbp1b 0.0385
6844 Penicillin-binding protein 1b pbp1b 0.0385
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0384
378 Alpha-2C adrenergic receptor ADRA2C 0.038
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0367
1757 Myeloperoxidase MPO 0.036
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0358
1898 Cytochrome P450 1B1 CYP1B1 0.0352
1385 Angiotensin-converting enzyme 2 ACE2 0.035
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0336
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0336
824 Sodium-dependent serotonin transporter SLC6A4 0.0328
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0324
468 Cytochrome P450 4A11 CYP4A11 0.0321
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.03
136 Estrogen receptor ESR1 0.0296
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0296
183 Vascular endothelial growth factor A VEGFA 0.0293
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0287
3923 Cholinesterase BCHE 0.0287
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.028
3811 Cytochrome P450 19A1 CYP19A1 0.028
6147 Solute carrier family 22 member 3 SLC22A3 0.0277
833 Organic cation/carnitine transporter 1 SLC22A4 0.0274
6136 Multidrug resistance-associated protein 5 ABCC5 0.0273
629 Alpha-2B adrenergic receptor ADRA2B 0.0269
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0261
4604 Liver carboxylesterase 1 CES1 0.0251
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0249
234 Plasminogen PLG 0.0246
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0241
33 Cystine/glutamate transporter SLC7A11 0.024
115 Penicillin-binding protein 2 mrdA 0.0235
6069 Penicillin-binding protein 2 mrdA 0.0235
6118 Penicillin-binding protein 2 penA 0.0235
6187 Penicillin-binding protein 2 pbpA 0.0235
6686 Penicillin-binding protein 2 pbp2 0.0235
6939 Penicillin-binding protein 2 mrdA 0.0235
7163 Penicillin-binding protein 2 pbpA 0.0235
6067 Penicillin binding protein 2a mecA 0.0233
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
3917 Methylenetetrahydrofolate reductase MTHFR 0.0229
556 Alpha-1A adrenergic receptor ADRA1A 0.0225
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0224
320 5-hydroxytryptamine 1A receptor HTR1A 0.0216
6031 Cytochrome P450 3A43 CYP3A43 0.0216
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0214
731 HIV-1 protease HIV-1 protease 0.0213
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0209
6070 Nischarin NISCH 0.0208
146 Androgen receptor AR 0.0205
338 DNA polymerase UL30 0.0203
379 DNA polymerase UL54 0.0203
697 DNA polymerase ORF28 0.0203
2482 DNA polymerase 43 0.0203
4104 DNA polymerase BALF5 0.0203
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0202
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0201
592 Carbonic anhydrase 4 CA4 0.0199
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0195
672 Prostaglandin F2-alpha receptor PTGFR 0.0192
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.019
295 Carbonic anhydrase 1 CA1 0.0185
380 Cytochrome P450 17A1 CYP17A1 0.0184
6167 Organic solute transporter subunit beta OSTB 0.0184
6166 Organic solute transporter subunit alpha OSTA 0.0183
3941 Amine oxidase [flavin-containing] A MAOA 0.0183
3426 Glutamine synthetase glnA 0.0183
3987 Glutamine synthetase GLUL 0.0183
3810 Catechol O-methyltransferase COMT 0.0182
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0179
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0173
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0172
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0172
6599 HTH-type transcriptional regulator ttgR ttgR 0.0171
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0169
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0168
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0168
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0167
6148 Multidrug resistance-associated protein 7 ABCC10 0.0167
502 5-hydroxytryptamine 2A receptor HTR2A 0.0166
831 D(2) dopamine receptor DRD2 0.0165
260 Cytochrome P450 51 ERG11 0.0164
761 Cytochrome P450 51 ERG11 0.0164
3163 Cytochrome P450 51 cyp51 0.0164
467 Delta-type opioid receptor OPRD1 0.0164
275 Arachidonate 5-lipoxygenase ALOX5 0.0159
357 Carbonic anhydrase 2 CA2 0.0159
847 Mu-type opioid receptor OPRM1 0.0154
341 5-hydroxytryptamine 3 receptor HTR3A 0.0152
871 Glucocorticoid receptor NR3C1 0.0152
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0152
159 Penicillin-binding protein 2B penA 0.0151
6121 Penicillin-binding protein 2B penA 0.0151
891 Dihydropteroate synthase folP 0.015
5359 Dihydropteroate synthase folP 0.015
7175 Dihydropteroate synthase sulI 0.015
3587 Gastrotropin FABP6 0.0149
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
4252 Penicillin-binding protein 5 dacA 0.0146
696 Kappa-type opioid receptor OPRK1 0.0146
6149 Solute carrier family 22 member 10 SLC22A10 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
373 Transthyretin TTR 0.0144
85 Growth hormone receptor GHR 0.0144
632 Alpha-1B adrenergic receptor ADRA1B 0.0142
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0142
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0138
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0138
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0137
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0137
756 Sex hormone-binding globulin SHBG 0.0137
122 P2Y purinoceptor 12 P2RY12 0.0136
70 Type-1 angiotensin II receptor AGTR1 0.0135
23 D(1A) dopamine receptor DRD1 0.0135
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0134
558 Solute carrier family 12 member 1 SLC12A1 0.0134
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0133
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0131
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0131
904 Glutathione S-transferase P GSTP1 0.013
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0129
6085 Fatty acid-binding protein, intestinal FABP2 0.0129
3639 Thymidine phosphorylase deoA 0.0128
3936 Thymidine phosphorylase TYMP 0.0128
869 Estrogen receptor beta ESR2 0.0128
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0127
6102 Arylamine N-acetyltransferase 2 NAT2 0.0127
509 Thymidine kinase TK 0.0126
570 Thymidine kinase TK 0.0126
2559 Thymidine kinase TK 0.0126
3430 Thymidine kinase tdk 0.0126
3518 Thymidine kinase TK 0.0126
5301 Thymidine kinase tdk 0.0126
5771 Thymidine kinase ORF36 0.0126
7009 Thymidine kinase ORF36 0.0126
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0124
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
6126 Carbonic anhydrase 7 CA7 0.0121
606 Cytochrome P450 27, mitochondrial CYP27A1 0.012
713 Sodium-dependent dopamine transporter SLC6A3 0.012
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.012
766 Beta-2 adrenergic receptor ADRB2 0.0119
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0119
465 Calmodulin CALM1 0.0119
527 Prostacyclin receptor PTGIR 0.0118
489 Monocarboxylate transporter 2 SLC16A7 0.0117
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0112
737 Mineralocorticoid receptor NR3C2 0.0112
1792 Tissue-type plasminogen activator PLAT 0.0111
500 Monocarboxylate transporter 4 SLC16A3 0.0111
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.011
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0109
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0108
3760 Penicillin-binding protein 5 precursor dacA 0.0105
3939 Amine oxidase [flavin-containing] B MAOB 0.0105
867 Penicillin-binding protein 3 pbpC 0.0102
6119 Penicillin-binding protein 3 pbp3 0.0102
7154 Penicillin-binding protein 3 pbp3 0.0102
7157 Penicillin-binding protein 3 LMHCC_2184 0.0102
7162 Penicillin-binding protein 3 pbpB 0.0102
7172 Penicillin-binding protein 3 pbp3 0.0102
6174 50S ribosomal protein L32 rpmF 0.0102
6182 Cytochrome P450 2J2 CYP2J2 0.0102
817 DNA topoisomerase 2-alpha TOP2A 0.0101
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0101
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0101
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0101
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.01
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.01
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.01
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0099
844 Epidermal growth factor receptor EGFR 0.0099
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0099
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0099
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0099
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0099
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0098
5650 NimA-related protein DR_0842 0.0098
24 Thymidylate synthase TMP1 0.0097
359 Thymidylate synthase TYMS 0.0097
2626 Thymidylate synthase thyA 0.0097
2729 Thymidylate synthase thyA 0.0097
5352 Thymidylate synthase THYA 0.0097
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0096
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
590 5-hydroxytryptamine 2C receptor HTR2C 0.0096
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0095
6137 Multidrug resistance-associated protein 6 ABCC6 0.0095
6151 Monocarboxylate transporter 10 SLC16A10 0.0095
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
811 Translocator protein TSPO 0.0092
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.009
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0089
365 Dihydrofolate reductase DHFR 0.0087
2381 Dihydrofolate reductase DFR1 0.0087
2833 Dihydrofolate reductase Not Available 0.0087
2931 Dihydrofolate reductase folA 0.0087
3544 Dihydrofolate reductase folA 0.0087
3682 Dihydrofolate reductase folA 0.0087
6642 Dihydrofolate reductase folA 0.0087
6756 Dihydrofolate reductase dfrA 0.0087
4116 Dihydropteroate synthetase Not Available 0.0087
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0086
65 Matrix metalloproteinase-9 Not Available 0.0086
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0082
2016 Dipeptidase 1 DPEP1 0.0082
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0082
6220 Aryl hydrocarbon receptor AHR 0.0081
2021 Thrombomodulin THBD 0.0081
6033 High affinity interleukin-8 receptor A CXCR1 0.0081
3808 Dihydropteroate synthase 2 folP2 0.008
3601 Dihydropteroate synthase 1 folP1 0.008
3807 Dihydropteroate synthase 1 folP1 0.008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0079
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0079
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0079
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0078
860 Nicotinamide N-methyltransferase NNMT 0.0078
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0078
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0078
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0078
699 Nicotinic acid receptor 1 GPR109A 0.0078
928 Nicotinic acid receptor 2 GPR109B 0.0078
2320 Thymidine kinase, cytosolic TK1 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
594 Thyroxine-binding globulin SERPINA7 0.0077
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0076
6014 Cytochrome P450 2A13 CYP2A13 0.0075
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0074
885 5-hydroxytryptamine 1B receptor HTR1B 0.0074
707 72 kDa type IV collagenase MMP2 0.0073
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0072
758 Thyroid hormone receptor alpha THRA 0.0071
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0071
84 Nuclear receptor 0B1 NR0B1 0.007
49 Endothelin B receptor EDNRB 0.007
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.007
158 Sodium channel protein type 1 subunit alpha SCN1A 0.007
789 Alpha-1D adrenergic receptor ADRA1D 0.0069
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0068
88 Retinoic acid receptor RXR-beta RXRB 0.0068
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0068
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
1010 Cytochrome P450 51A1 CYP51A1 0.0068
193 Beta-1 adrenergic receptor ADRB1 0.0067
638 D(3) dopamine receptor DRD3 0.0067
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0066
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0066
469 Annexin A1 ANXA1 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0066
273 Apoptosis regulator Bcl-2 BCL2 0.0066
2981 Phospholipase A2, membrane associated PLA2G2A 0.0065
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0065
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0065
504 Mast/stem cell growth factor receptor KIT 0.0065
725 5-hydroxytryptamine 1D receptor HTR1D 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
921 Glutamate receptor 2 GRIA2 0.0064
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0064
346 Thyroid hormone receptor beta-1 THRB 0.0063
133 Dihydropterate synthase sulI 0.0063
124 Histamine H2 receptor HRH2 0.0062
130 Prostacyclin synthase PTGIS 0.0062
5626 Nucleoside diphosphate kinase B NME2 0.006
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.006
1541 Metalloproteinase mmp20 0.006
777 Tumor necrosis factor TNF 0.0059
1196 Complement decay-accelerating factor CD55 0.0059
427 Substance-P receptor TACR1 0.0059
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0058
362 Melatonin receptor type 1B MTNR1B 0.0058
571 Melatonin receptor type 1A MTNR1A 0.0058
407 Vascular endothelial growth factor receptor 2 KDR 0.0058
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0058
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0058
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0057
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0056
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0055
4120 NADPH--cytochrome P450 reductase POR 0.0055
952 Dipeptidyl peptidase 4 DPP4 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0054
6432 Transporter snf 0.0054
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0053
94 5-hydroxytryptamine 4 receptor HTR4 0.0053
1039 Histone deacetylase 9 HDAC9 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
1275 Estrogen sulfotransferase SULT1E1 0.0052
162 Retinoic acid receptor gamma-1 RARG 0.0052
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0052
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0052
5482 Sialidase-2 NEU2 0.0052
780 Retinoic acid receptor RXR-gamma RXRG 0.0052
6837 Serine/threonine-protein kinase 17B STK17B 0.0052
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0052
432 D(4) dopamine receptor DRD4 0.0052
2808 Chloramphenicol acetyltransferase 3 cat3 0.0052
438 Taste receptor type 1 member 2 TAS1R2 0.0051
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0051
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
26 Vascular endothelial growth factor receptor 3 FLT4 0.005
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0049
1630 Integrin beta-2 ITGB2 0.0049
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0049
199 Monocarboxylate transporter 8 SLC16A2 0.0049
340 Apoptotic protease-activating factor 1 APAF1 0.0049
719 Retinoic acid receptor responder protein 1 RARRES1 0.0049
770 Retinoic acid-induced protein 3 GPRC5A 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
976 Platelet glycoprotein IX GP9 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
614 Progesterone receptor PGR 0.0048
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0048
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0048
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0048
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0048
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0048
32 Vascular endothelial growth factor receptor 1 FLT1 0.0048
511 5-hydroxytryptamine 1F receptor HTR1F 0.0047
2417 Chloramphenicol acetyltransferase cat 0.0047
3278 Chloramphenicol acetyltransferase cat 0.0047
518 Peroxidase/catalase T katG 0.0047
2810 Dr hemagglutinin structural subunit draA 0.0047
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0047
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0046
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0046
3932 Glutathione S-transferase A2 GSTA2 0.0046
53 Solute carrier family 12 member 5 SLC12A5 0.0046
663 Solute carrier family 12 member 4 SLC12A4 0.0046
1291 cAMP response element-binding protein CREB1 0.0046
3014 Ribonuclease UK114 HRSP12 0.0046
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0046
5428 Replication protein repA 0.0046
3617 Non-heme chloroperoxidase cpo 0.0046
5426 Non-heme chloroperoxidase cpo 0.0046
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0046
3018 HTH-type transcriptional regulator malT malT 0.0046
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0046
4122 Histone deacetylase 2 HDAC2 0.0046
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0045
5300 Antigen peptide transporter 1 TAP1 0.0045
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0045
4210 Toll-like receptor 4 TLR4 0.0045
284 DNA-directed RNA polymerase beta chain rpoB 0.0044
5773 DNA-directed RNA polymerase beta chain rpoB 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0044
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0044
634 Squalene monooxygenase SQLE 0.0044
7196 Squalene monooxygenase ERG1 0.0044
825 Arsenical pump-driving ATPase ASNA1 0.0043
3435 Arsenical pump-driving ATPase arsA 0.0043
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0043
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0043
733 Activin receptor type 1B ACVR1B 0.0043
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0043
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0043
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0043
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0043
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0043
154 AFG3-like protein 2 AFG3L2 0.0043
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0043
395 ALK tyrosine kinase receptor Not Available 0.0043
310 Solute carrier family 12 member 2 SLC12A2 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
569 Retinal dehydrogenase 2 ALDH1A2 0.0042
228 Beta platelet-derived growth factor receptor PDGFRB 0.0042
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0042
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0042
6218 Pannexin-1 PANX1 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
29 Tubulin beta-1 chain TUBB1 0.0041
1517 Beta-3 adrenergic receptor ADRB3 0.0041
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
408 Riboflavin kinase RFK 0.0041
4203 Histamine N-methyltransferase HNMT 0.0041
823 Fibroblast growth factor receptor 2 FGFR2 0.004
6044 Serum paraoxonase/lactonase 3 PON3 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
232 Corticosteroid-binding globulin SERPINA6 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
2958 Probable tautomerase ydcE pptA 0.004
611 Retinal dehydrogenase 1 ALDH1A1 0.004
2573 Cocaine esterase cocE 0.004
7263 Cocaine esterase Not Available 0.004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
3937 Fatty-acid amide hydrolase FAAH 0.0039
163 D(1B) dopamine receptor DRD5 0.0039
6131 Carbonic anhydrase 14 CA14 0.0039
2599 Tyrosine-protein kinase HCK HCK 0.0039
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0039
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0039
459 Retinoic acid receptor RXR-alpha RXRA 0.0039
3115 Ras-related protein Rab-9 RAB9A 0.0039
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0039
161 Tubulin beta chain TUBB 0.0038
312 Tubulin beta chain TUB2 0.0038
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0038
3809 Estrogen-related receptor gamma ESRRG 0.0038
4217 Telomerase reverse transcriptase TERT 0.0038
292 Activin receptor type-1 ACVR1 0.0038
849 Activated CDC42 kinase 1 TNK2 0.0038
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0038
297 Adenylate cyclase type 1 ADCY1 0.0038
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0038
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0038
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0038
293 Gamma-glutamyl hydrolase GGH 0.0038
5353 Glutamate decarboxylase alpha gadA 0.0037
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0037
1648 Elastin ELN 0.0037
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0037
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0037
572 Integrin alpha-L ITGAL 0.0037
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0037
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0037
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0037
1192 Sulfotransferase 1A1 SULT1A1 0.0037
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0037
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0037
6122 Carbonic anhydrase 3 CA3 0.0037
1050 Bile salt sulfotransferase SULT2A1 0.0036
2539 Tubulin alpha-1 chain TUBA4A 0.0036
3007 Carbonic anhydrase 12 CA12 0.0036
4205 Carbonic anhydrase 9 CA9 0.0036
208 DNA-directed RNA polymerase beta' chain rpoC 0.0036
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0036
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0035
484 Tyrosine-protein kinase ABL2 ABL2 0.0035
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0035
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0035
1618 High affinity nerve growth factor receptor NTRK1 0.0035
4238 50S ribosomal protein L4 rplD 0.0035
5578 50S ribosomal protein L4 rplD 0.0035
6173 50S ribosomal protein L4 rplD 0.0035
6219 50S ribosomal protein L4 rplD 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0035
1656 CYP2B protein CYP2B 0.0034
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0034
4773 Deoxycytidine kinase DCK 0.0033
1650 Heme carrier protein 1 SLC46A1 0.0033
5880 Thrombopoietin receptor MPL 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0033
740 Argininosuccinate synthase ASS1 0.0032
865 Argininosuccinate synthase ASS1 0.0032
2680 Argininosuccinate synthase argG 0.0032
3194 Argininosuccinate synthase argG 0.0032
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0032
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
4237 50S ribosomal protein L22 rplV 0.0032
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0032
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0032
5934 Cytochrome P450 26A1 CYP26A1 0.0032
1360 Sphingomyelin phosphodiesterase SMPD1 0.0032
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0031
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0031
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0031
6042 Prostaglandin reductase 2 PTGR2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0031
528 5-hydroxytryptamine 1E receptor HTR1E 0.0031
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0031
482 Glycine receptor subunit alpha-1 GLRA1 0.0031
6020 Aldehyde oxidase AOX1 0.003
2693 Heat-labile enterotoxin B chain eltB 0.003
6021 Adenosine kinase ADK 0.003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.003
6103 Arylamine N-acetyltransferase 1 NAT1 0.003
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.003
654 Flavin reductase BLVRB 0.0029
6645 D-amino-acid oxidase DAO 0.0029
661 ADP/ATP translocase 1 SLC25A4 0.0029
4311 tRNA TRDMT1 0.0029
4325 tRNA trmD 0.0029
4328 tRNA trmD 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
581 Cytochrome P450 2R1 CYP2R1 0.0028
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0028
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0028
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0028
1867 Major prion protein PRNP 0.0028
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0027
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0027
1025 Aquaporin-1 AQP1 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6146 High affinity copper uptake protein 1 SLC31A1 0.0027
1992 Vitamin D-binding protein GC 0.0027
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0027
7 Nitric oxide synthase, inducible NOS2 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
319 Opioid receptor, sigma 1 OPRS1 0.0026
54 Prothrombin F2 0.0026
716 5-hydroxytryptamine 7 receptor HTR7 0.0026
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0026
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0026
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0026
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
751 Potassium channel subfamily K member 6 KCNK6 0.0026
153 Dopamine beta-hydroxylase DBH 0.0026
1629 Transcription factor AP-1 JUN 0.0025
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0025
1507 Cytochrome c CYCS 0.0025
4103 Proteasome subunit beta type 2 PSMB2 0.0025
4102 Proteasome subunit beta type 5 PSMB5 0.0025
4101 Proteasome subunit beta type 1 PSMB1 0.0025
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
106 Cannabinoid receptor 2 CNR2 0.0024
6138 Multidrug resistance protein 3 ABCB4 0.0024
1313 Lactoylglutathione lyase GLO1 0.0024
229 Retinoic acid receptor beta RARB 0.0024
172 Potassium channel subfamily K member 1 KCNK1 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
16 Adenosine A1 receptor ADORA1 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
1178 Adenosine A2a receptor ADORA2A 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
239 Coagulation factor X F10 0.0023
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0023
4760 Mll3241 protein mll3241 0.0023
68 Cannabinoid receptor 1 CNR1 0.0022
563 Thyroid peroxidase TPO 0.0022
174 Sigma 1-type opioid receptor SIGMAR1 0.0022
4992 Cytochrome c peroxidase Not Available 0.0022
5818 Folate receptor alpha FOLR1 0.0022
3086 Plasmepsin-2 Not Available 0.0022
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
165 FL cytokine receptor FLT3 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0021
5787 Angiopoietin-1 receptor TEK 0.0021
3913 Glutamic acid decarboxylase GAD65 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.002
1123 Eosinophil cationic protein RNASE3 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
856 Vitamin D3 receptor VDR 0.002
822 Aldose reductase AKR1B1 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
1483 Membrane copper amine oxidase AOC3 0.0019
1654 Interleukin-1 beta IL1B 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
267 Plasminogen activator inhibitor 1 SERPINE1 0.0019
164 Histamine H4 receptor HRH4 0.0019
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0019
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0019
1253 Interferon gamma IFNG 0.0018
3856 Fibroblast growth factor receptor 3 FGFR3 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
517 Alcohol dehydrogenase 1C ADH1C 0.0018
735 Alanine aminotransferase 1 GPT 0.0017
3904 Alanine aminotransferase 2 GPT2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0017
2112 Toll-like receptor 9 TLR9 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
3830 Calreticulin CALR 0.0017
6221 Steroid hormone receptor ERR1 ESRRA 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0016
1256 5-hydroxytryptamine 6 receptor HTR6 0.0016
4948 Cytochrome c-553 Not Available 0.0016
4923 Cytochrome c3 DvMF_2499 0.0016
4945 Cytochrome c3 Not Available 0.0016
4949 Cytochrome c3 DVU_3171 0.0016
4968 Cytochrome c3 cytc3 0.0016
4997 Cytochrome c3 SO_2727 0.0016
5219 Cytochrome c3 cyd 0.0016
4902 Nine-heme cytochrome c Ddes_2038 0.0016
3189 High-molecular-weight cytochrome c hmcA 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
814 Ryanodine receptor 1 RYR1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
494 Caspase-1 CASP1 0.0015
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
6048 Troponin C, skeletal muscle TNNC2 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
251 Alcohol dehydrogenase 1A ADH1A 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
4386 Hemoglobin-like protein HbN glbN 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
4954 Soluble cytochrome b558 Not Available 0.0014
4934 Cytochrome c-551 nirM 0.0014
5218 Cytochrome c-551 nirM 0.0014
4905 Cytochrome c2 Not Available 0.0014
4939 Cytochrome c2 cycA 0.0014
4964 Cytochrome c2 cycA 0.0014
4979 Cytochrome c2 cycA 0.0014
6673 Cytochrome c2 cycA 0.0014
4947 Bacterial hemoglobin vhb 0.0014
4915 Cytochrome c-550 psbV 0.0014
4959 Cytochrome c-550 psbV 0.0014
5216 Cytochrome c-550 psbV 0.0014
4925 Cytochrome c-type protein SHP shp 0.0014
4998 Hemoglobin-like protein yjbI yjbI 0.0014
4975 Cytochrome c-556 RPA3973 0.0014
4943 Cytochrome c6 petJ 0.0014
4984 Neuroglobin NGB 0.0014
4916 Cyanoglobin glbN 0.0014
3116 Bacterioferritin bfr 0.0014
4906 Bacterioferritin bfr 0.0014
4965 Bacterioferritin bfr 0.0014
4936 Cytochrome c2 iso-2 Not Available 0.0014
4907 Cytochrome c-L moxG 0.0014
6865 Cytochrome c-L moxG 0.0014
4909 CooA protein cooA 0.0013
4994 Hemoglobin-like protein HbO glbO 0.0013
644 Heme oxygenase 2 HMOX2 0.0013
4982 Heme oxygenase 2 pbsA2 0.0013
4942 Diheme cytochrome c napB napB 0.0013
4935 Cytochrome c-554 cycA1 0.0013
4961 Hemophore HasA hasA 0.0013
4971 Nonaheme cytochrome c hmcA 0.0013
4910 Cytoglobin CYGB 0.0013
5000 HemO hemO 0.0013
4904 Cytochrome c family protein GSU1996 0.0013
4981 Iron-starvation protein PigA pigA 0.0013
4989 Cytochrome c551 peroxidase ccp 0.0013
5222 Cytochrome c551 peroxidase ccpA 0.0013
4976 Apocytochrome f petA 0.0013
6407 Apocytochrome f petA 0.0013
4999 Cytochrome P450 165B3 CYP165B3 0.0013
4764 Cytochrome P450 165C4 CYP165C4 0.0013
4960 Putative cytochrome P450-family protein SCO7417 0.0013
4931 Cytochrome P450 167A1 CYP167A1 0.0013
4926 Heme-based aerotactic transducer hemAT hemAT 0.0013
4937 Cytochrome oxidase subunit II rcoxA 0.0013
4903 Methyl-accepting chemotaxis protein Tar4 0.0013
4993 Hydroxylamine oxidoreductase hao1 0.0013
4922 Cytochrome c, putative SO_4144 0.0013
4972 P450cin cinA 0.0013
3093 Catalase HPII katE 0.0013
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0013
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0013
4952 Catalase/peroxidase katA 0.0013
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0013
818 50S ribosomal protein L10 rplJ 0.0013
820 Glycine receptor subunit alpha-2 GLRA2 0.0013
2077 Caspase-3 CASP3 0.0013
1262 Corticotropin-lipotropin POMC 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
5923 Microtubule-associated protein tau MAPT 0.0013
5924 Microtubule-associated protein 4 MAP4 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0012
819 Penicillin-binding protein 4 dacB 0.0012
5590 N utilization substance protein B homolog nusB 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
3221 Cytochrome c4 cc4 0.0012
444 Alcohol dehydrogenase 1B ADH1B 0.0012
702 UMP-CMP kinase CMPK1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
1852 Microtubule-associated protein 2 MAP2 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
474 Acetylcholinesterase ACHE 0.0011
1864 RET proto-oncogene RET 0.0011
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0011
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0011
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5006 RNASE4 protein RNASE4 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
2540 Choloylglycine hydrolase cbh 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0011
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0011
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0011
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0011
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0011
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0011
2207 Rhodopsin RHO 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
997 Protein kinase C beta type PRKCB 0.001
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
283 SEC14-like protein 2 SEC14L2 0.001
4920 Peroxidase/catalase katG 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
6501 Fatty acid-binding protein, liver FABP1 0.001
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.001
2603 Beta-lactamase II blm 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
2119 Cytochrome b5 CYB5A 0.001
2149 Angiogenin ANG 0.001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.001
4990 PpcA ppcA 0.001
4988 Sulfite oxidase, mitochondrial SUOX 0.001
3375 Acidic cytochrome c3 Not Available 0.001
3583 6-phosphogluconolactonase pgl 0.001
4385 Cytochrome c' Not Available 0.001
4967 Cytochrome c' cycA 0.001
5038 Cytochrome c' Not Available 0.001
5223 Cytochrome c' cycP 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
2915 Sensor protein fixL fixL 0.001
4944 Sensor protein fixL fixL 0.001
3570 Cytochrome P450 152A1 cypC 0.001
4289 Cytochrome P450 TT_P0059 0.001
6262 Cytochrome P450 staP 0.001
4813 Heme oxygenase hmuO 0.001
5769 Heme oxygenase Not Available 0.001
2230 Catalase CAT 0.001
3249 Catalase katA 0.001
3625 Catalase katA 0.001
4539 Catalase katA 0.001
4941 Catalase katB 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0009
6459 Glycodelin PAEP 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0009
2216 Fibroblast growth factor receptor 4 FGFR4 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0009
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0009
2286 Isocitrate dehydrogenase [NADP] icd 0.0009
2302 Isocitrate dehydrogenase [NADP] icd 0.0009
2771 Isocitrate dehydrogenase [NADP] icd 0.0009
3957 Adenosine deaminase ADA 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
1341 Histamine H3 receptor HRH3 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6677 Myelin P2 protein PMP2 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
411 Glycine N-methyltransferase GNMT 0.0009
3670 Soluble cytochrome b562 precursor cybC 0.0009
3411 Cytochrome P450 121 cyp121 0.0009
3291 Cytochrome c-552 cycA 0.0008
4927 Cytochrome c-552 nrfA 0.0008
4938 Cytochrome c-552 cycA 0.0008
4953 Cytochrome c-552 nrfA 0.0008
5217 Cytochrome c-552 cycM 0.0008
2617 Nitric oxide synthase oxygenase nos 0.0008
2701 Nitric oxide synthase oxygenase nos 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
5579 Carboxypeptidase B CPB1 0.0008
6500 Phospholipase A2 PLA2G1B 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0008
605 Fumarate reductase flavoprotein subunit frdA 0.0008
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0008
3673 Fumarate reductase flavoprotein subunit fccA 0.0008
4912 Fumarate reductase flavoprotein subunit ifcA 0.0008
6549 Fumarate reductase flavoprotein subunit frdA 0.0008
2972 6-deoxyerythronolide B hydroxylase eryF 0.0008
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
4608 Putative cytochrome P450 SCO1207 0.0007
4963 Putative cytochrome P450 SCO2884 0.0007
6254 Putative cytochrome P450 SCO6998 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
6824 Tyrosine-protein kinase Lyn LYN 0.0007
358 Cystathionine beta-synthase CBS 0.0007
1374 Natriuretic peptides B NPPB 0.0007
1827 Gap junction alpha-1 protein GJA1 0.0007
1908 Vascular cell adhesion protein 1 VCAM1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
4192 DNA topoisomerase 2-beta TOP2B 0.0007
3947 Xanthine dehydrogenase/oxidase XDH 0.0007
693 Hemoglobin subunit beta HBB 0.0006
5682 Ribonuclease pancreatic RNASE1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6268 Hydroxyacid oxidase 1 HAO1 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
828 Phenylalanine-4-hydroxylase PAH 0.0006
3109 Phenylalanine-4-hydroxylase phhA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2298 Cytochrome P450-cam camC 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0005
1268 Neuropeptide S receptor NPSR1 0.0005
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0005
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0004
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
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