DT-Web

DB00482 - Celecoxib


Identification
Name Celecoxib
Accession Number DB00482 (APRD00373)
Type small molecule
Description Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex. In some countries, it is branded Celebra. Celecoxib is available by prescription in capsule form.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 381.372
Groups approved
Monoisotopic Weight 381.075882012
Pharmacology
Indication For relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis
Mechanism of action The mechanism of action of celecoxib is believed to be due to inhibition of prostaglandin synthesis. Unlike most NSAIDs, which inhibit both types of cyclooxygenases (COX-1 and COX-2), celecoxib is a selective noncompetitive inhibitor of cyclooxygenase-2 (COX-2) enzyme. It binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active COX-2 binding site. Both COX-1 and COX-2 catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane.
Absorption Well absorbed in the gastrointestinal tract. When a single dose of 200 mg is given to healthy subjects, peak plasma levels occur 3 hours after an oral dose. The peak plasma level is 705 ng/mL. Absolute bioavailability studies have not been conducted. When multiple doses are given, steady-state is reached on or before Day 5. When taken with a high fat meal, peak plasma levels are delayed for about 1 to 2 hours with an increase in total absorption (AUC) of 10% to 20%.
Protein binding 97%, primarily to albumin and, to a lesser extent, a1-acid glycoprotein. Celecoxib is not preferentially bound to red blood cells.
Biotransformation Hepatic. Celecoxib metabolism is primarily mediated via cytochrome P450 2C9. Three metabolites, a primary alcohol, the corresponding carboxylic acid and its glucuronide conjugate, have been identified in human plasma. CYP3A4 is also involved in the hydroxylation of celecoxib but to a lesser extent. These metabolites are inactive as COX-1 or COX-2 inhibitors.
Route of elimination Celecoxib is eliminated predominantly by hepatic metabolism with little (<3%) unchanged drug recovered in the urine and feces. 57% of the oral dose is excreted in the feces and 27% is excreted into the urine. The primary metabolite in urine and feces was the carboxylic acid metabolite (73%). The amount of glucuronide in the urine is low.
Toxicity Symptoms of overdose include breathing difficulties, coma, drowsiness, gastrointestinal bleeding, high blood pressure, kidney failure, nausea, sluggishness, stomach pain, and vomiting.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Celecoxib may increase the anticoagulant effect of acenocoumarol.
Anisindione Celecoxib may increase the anticoagulant effect of anisindione.
Azilsartan medoxomil Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Dicumarol Celecoxib may increase the anticoagulant effect of dicumarol.
Eltrombopag Eltrombopag increases levels of Celecoxib via metabolism decrease.
Fluconazole Fluconazole may increase the effect of celecoxib.
Lithium The COX-2 inhibitor increases serum levels of lithium
Pralatrexate NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Rifampin Rifampin, a strong CYP2C9 inducer, may decrease the serum levels of celecoxib by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects if rifampin is initiated, discontinued or dose changed.
Telmisartan Concomitant use of Telmisartan and Celecoxib may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol The NSAID, Celecoxib, may antagonize the antihypertensive effect of Timolol.
Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Celecoxib. Consider alternate therapy or monitor for changes in Celecobix therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Trandolapril The NSAID, Celecoxib, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Celecoxib is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Celecoxib. Monitor for increased bleeding during concomitant thearpy.
Tretinoin The moderate CYP2C8 inhibitor, Celecoxib, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Celecoxib is initiated, discontinued to dose changed.
Vilazodone Selective Serotonin Reuptake Inhibitors may enhance the antiplatelet effect of NSAID (COX-2 Inhibitor). To minimize the risk of bleeding associated with this combination, consider using alternative analgesics, when appropriate, and/or addition of an gastroprotective agent, such as a proton pump inhibitor for the time that combined selective serotonin reuptake inhibitor (SSRIs) and nonsteroidal anti-inflammatory drugs (NSAIDs) is necessary.
Warfarin Celecoxib may increase the anticoagulant effect of warfarin.
Food Interactions
  • Taking this product with a high-fat meal will delay the Cmax, but total absorption will be increased by 10 to 20%.
  • Take without regard to meals.

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Sigthorsson G, Simpson RJ, Walley M, Anthony A, Foster R, Hotz-Behoftsitz C, Palizban A, Pombo J, Watts J, Morham SG, Bjarnason I: COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice. Gastroenterology. 2002 Jun;122(7):1913-23. - Pubmed
  • Scheiman JM: Outcomes studies of the gastrointestinal safety of cyclooxygenase-2 inhibitors. Cleve Clin J Med. 2002;69 Suppl 1:SI40-6. - Pubmed
  • Reddy BS, Rao CV: Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors. J Environ Pathol Toxicol Oncol. 2002;21(2):155-64. - Pubmed
  • Ahmad SR, Kortepeter C, Brinker A, Chen M, Beitz J: Renal failure associated with the use of celecoxib and rofecoxib. Drug Saf. 2002;25(7):537-44. - Pubmed
  • Lu S, Zhang X, Badawi AF, El-Sohemy A, Archer MC: Cyclooxygenase-2 inhibitor celecoxib inhibits promotion of mammary tumorigenesis in rats fed a high fat diet rich in n-6 polyunsaturated fatty acids. Cancer Lett. 2002 Oct 8;184(1):7-12. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4435
3-phosphoinositide-dependent protein kinase 1
Name 3-phosphoinositide-dependent protein kinase 1
Gene Name PDPK1
Pharmacological action unknown
Actions inhibitor
References
  • Kulp SK, Yang YT, Hung CC, Chen KF, Lai JP, Tseng PH, Fowble JW, Ward PJ, Chen CS: 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells. Cancer Res. 2004 Feb 15;64(4):1444-51. - Pubmed
  • Zhu J, Huang JW, Tseng PH, Yang YT, Fowble J, Shiau CW, Shaw YJ, Kulp SK, Chen CS: From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004 Jun 15;64(12):4309-18. - Pubmed
  • Tong Z, Wu X, Ovcharenko D, Zhu J, Chen CS, Kehrer JP: Neutrophil gelatinase-associated lipocalin as a survival factor. Biochem J. 2005 Oct 15;391(Pt 2):441-8. - Pubmed
  • Li J, Zhu J, Melvin WS, Bekaii-Saab TS, Chen CS, Muscarella P: A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth. J Gastrointest Surg. 2006 Feb;10(2):207-14. - Pubmed
  • Tseng PH, Wang YC, Weng SC, Weng JR, Chen CS, Brueggemeier RW, Shapiro CL, Chen CY, Dunn SE, Pollak M, Chen CS: Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor. Mol Pharmacol. 2006 Nov;70(5):1534-41. Epub 2006 Aug 3. - Pubmed
DTHybrid score 1.2248

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Rodrigues AD: Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? Drug Metab Dispos. 2005 Nov;33(11):1567-75. Epub 2005 Aug 23. - Pubmed
  • Martinez C, Blanco G, Garcia-Martin E, Agundez JA: [Clinical pharmacogenomics for CYP2C8 and CYP2C9: general concepts and application to the use of NSAIDs]. Farm Hosp. 2006 Jul-Aug;30(4):240-8. - Pubmed
DTHybrid score 0.3489
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Davies NM, McLachlan AJ, Day RO, Williams KM: Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet. 2000 Mar;38(3):225-42. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues AD, Rushmore TH, Shou M: Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):368-74. - Pubmed
DTHybrid score 0.4828
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Werner U, Werner D, Rau T, Fromm MF, Hinz B, Brune K: Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans. Clin Pharmacol Ther. 2003 Aug;74(2):130-7. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4394
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5852

Transporters


Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score 0.1829

Carriers


Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions
References Not Available
DTHybrid score 0.1829

Predictions


Id Partner name Gene Name Score
20 Prostaglandin G/H synthase 1 PTGS1 0.2787
6016 Cytochrome P450 2C19 CYP2C19 0.2688
1588 Multidrug resistance protein 1 ABCB1 0.2465
4200 Cytochrome P450 1A2 CYP1A2 0.2264
4118 Cytochrome P450 3A5 CYP3A5 0.1785
6030 Cytochrome P450 2B6 CYP2B6 0.1405
6107 Cytochrome P450 3A7 CYP3A7 0.1273
6013 Cytochrome P450 2E1 CYP2E1 0.1262
1729 Solute carrier family 22 member 6 SLC22A6 0.1149
6392 Myotonin-protein kinase DMPK 0.1064
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0939
6024 Cytochrome P450 1A1 CYP1A1 0.0883
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0814
5718 Cytochrome P450 2A6 CYP2A6 0.0771
6142 Solute carrier family 22 member 8 SLC22A8 0.0745
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0723
6391 Protein kinase C iota type PRKCI 0.071
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0678
862 Multidrug resistance-associated protein 1 ABCC1 0.0665
492 Histamine H1 receptor HRH1 0.0631
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0619
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0612
824 Sodium-dependent serotonin transporter SLC6A4 0.058
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0573
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0562
556 Alpha-1A adrenergic receptor ADRA1A 0.0543
6106 Cytochrome P450 2C18 CYP2C18 0.0541
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0538
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0536
502 5-hydroxytryptamine 2A receptor HTR2A 0.049
1024 Solute carrier family 22 member 11 SLC22A11 0.0483
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0482
6145 Solute carrier family 22 member 1 SLC22A1 0.0478
6136 Multidrug resistance-associated protein 5 ABCC5 0.0454
6143 Solute carrier family 22 member 7 SLC22A7 0.0432
831 D(2) dopamine receptor DRD2 0.0431
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0423
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0417
320 5-hydroxytryptamine 1A receptor HTR1A 0.0416
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0384
6144 Solute carrier family 22 member 2 SLC22A2 0.0378
891 Dihydropteroate synthase folP 0.0378
5359 Dihydropteroate synthase folP 0.0378
7175 Dihydropteroate synthase sulI 0.0378
766 Beta-2 adrenergic receptor ADRB2 0.0368
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0363
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0355
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0352
632 Alpha-1B adrenergic receptor ADRA1B 0.0345
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0338
847 Mu-type opioid receptor OPRM1 0.0337
3811 Cytochrome P450 19A1 CYP19A1 0.0335
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0327
193 Beta-1 adrenergic receptor ADRB1 0.032
1898 Cytochrome P450 1B1 CYP1B1 0.0318
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0318
713 Sodium-dependent dopamine transporter SLC6A3 0.0314
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0312
776 Bile salt export pump ABCB11 0.0311
318 Alpha-2A adrenergic receptor ADRA2A 0.0303
2379 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide DAPP1 0.0303
2355 Tyrosine-protein kinase BTK BTK 0.0303
2348 Pleckstrin homology domain-containing family A member 4 PLEKHA4 0.0302
1757 Myeloperoxidase MPO 0.03
23 D(1A) dopamine receptor DRD1 0.0294
871 Glucocorticoid receptor NR3C1 0.0282
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0281
136 Estrogen receptor ESR1 0.0279
789 Alpha-1D adrenergic receptor ADRA1D 0.0277
118 Organic cation/carnitine transporter 2 SLC22A5 0.0277
696 Kappa-type opioid receptor OPRK1 0.0277
6141 Sodium/bile acid cotransporter SLC10A1 0.0272
590 5-hydroxytryptamine 2C receptor HTR2C 0.0271
275 Arachidonate 5-lipoxygenase ALOX5 0.027
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0263
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0258
467 Delta-type opioid receptor OPRD1 0.0258
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0256
3923 Cholinesterase BCHE 0.0254
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0246
731 HIV-1 protease HIV-1 protease 0.0241
465 Calmodulin CALM1 0.0237
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0236
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0236
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0236
844 Epidermal growth factor receptor EGFR 0.0233
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0231
6147 Solute carrier family 22 member 3 SLC22A3 0.0231
2530 Protein kinase C theta type PRKCQ 0.0226
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.022
4534 Cytohesin-2 CYTH2 0.0219
341 5-hydroxytryptamine 3 receptor HTR3A 0.0217
146 Androgen receptor AR 0.0215
3941 Amine oxidase [flavin-containing] A MAOA 0.0211
738 Monocarboxylate transporter 1 SLC16A1 0.0209
373 Transthyretin TTR 0.0204
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0203
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0203
4604 Liver carboxylesterase 1 CES1 0.0193
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0192
6148 Multidrug resistance-associated protein 7 ABCC10 0.0191
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0189
1159 Interleukin-6 IL6 0.0185
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.018
24 Thymidylate synthase TMP1 0.0178
359 Thymidylate synthase TYMS 0.0178
2626 Thymidylate synthase thyA 0.0178
2729 Thymidylate synthase thyA 0.0178
5352 Thymidylate synthase THYA 0.0178
6220 Aryl hydrocarbon receptor AHR 0.0176
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0174
6137 Multidrug resistance-associated protein 6 ABCC6 0.017
6085 Fatty acid-binding protein, intestinal FABP2 0.017
70 Type-1 angiotensin II receptor AGTR1 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
3939 Amine oxidase [flavin-containing] B MAOB 0.0169
122 P2Y purinoceptor 12 P2RY12 0.0167
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0166
833 Organic cation/carnitine transporter 1 SLC22A4 0.0166
1648 Elastin ELN 0.0165
2473 Tyrosine-protein kinase CSK CSK 0.0164
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0164
380 Cytochrome P450 17A1 CYP17A1 0.0164
777 Tumor necrosis factor TNF 0.0163
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0162
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0162
614 Progesterone receptor PGR 0.0162
504 Mast/stem cell growth factor receptor KIT 0.0161
885 5-hydroxytryptamine 1B receptor HTR1B 0.0156
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0154
638 D(3) dopamine receptor DRD3 0.0153
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0153
6031 Cytochrome P450 3A43 CYP3A43 0.0151
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.015
6102 Arylamine N-acetyltransferase 2 NAT2 0.015
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.015
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0149
3947 Xanthine dehydrogenase/oxidase XDH 0.0149
1656 CYP2B protein CYP2B 0.0149
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0147
629 Alpha-2B adrenergic receptor ADRA2B 0.0147
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0146
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0146
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0145
1050 Bile salt sulfotransferase SULT2A1 0.0145
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
6182 Cytochrome P450 2J2 CYP2J2 0.0139
5626 Nucleoside diphosphate kinase B NME2 0.0139
260 Cytochrome P450 51 ERG11 0.0139
761 Cytochrome P450 51 ERG11 0.0139
3163 Cytochrome P450 51 cyp51 0.0139
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0137
468 Cytochrome P450 4A11 CYP4A11 0.0136
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0133
183 Vascular endothelial growth factor A VEGFA 0.0133
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0133
232 Corticosteroid-binding globulin SERPINA6 0.0132
378 Alpha-2C adrenergic receptor ADRA2C 0.0131
3312 Fatty acid-binding protein, brain FABP7 0.0131
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0129
436 5-hydroxytryptamine 2B receptor HTR2B 0.0126
228 Beta platelet-derived growth factor receptor PDGFRB 0.0126
6033 High affinity interleukin-8 receptor A CXCR1 0.0125
811 Translocator protein TSPO 0.0124
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0123
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0121
756 Sex hormone-binding globulin SHBG 0.012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0119
2183 Fatty acid-binding protein, adipocyte FABP4 0.0119
6043 Putative G-protein coupled receptor 44 GPR44 0.0118
3602 Anti-sigma F factor antagonist spoIIAA 0.0118
2514 Phosphocarrier protein HPr ptsH 0.0118
5689 Phosphocarrier protein HPr ptsH 0.0118
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0118
432 D(4) dopamine receptor DRD4 0.0117
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0117
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0116
1517 Beta-3 adrenergic receptor ADRB3 0.0116
407 Vascular endothelial growth factor receptor 2 KDR 0.0116
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0115
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0115
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0114
2408 Tyrosine-protein kinase SYK SYK 0.0114
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0114
725 5-hydroxytryptamine 1D receptor HTR1D 0.0113
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0112
817 DNA topoisomerase 2-alpha TOP2A 0.0111
365 Dihydrofolate reductase DHFR 0.0111
2381 Dihydrofolate reductase DFR1 0.0111
2833 Dihydrofolate reductase Not Available 0.0111
2931 Dihydrofolate reductase folA 0.0111
3544 Dihydrofolate reductase folA 0.0111
3682 Dihydrofolate reductase folA 0.0111
6642 Dihydrofolate reductase folA 0.0111
6756 Dihydrofolate reductase dfrA 0.0111
5294 Nucleoside diphosphate kinase A NME1 0.0111
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0111
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.011
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0109
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0109
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0108
2211 Fatty acid-binding protein, heart FABP3 0.0108
645 Penicillin-binding protein 1A mrcA 0.0106
5805 Penicillin-binding protein 1A ponA 0.0106
6185 Penicillin-binding protein 1A mrcA 0.0106
6799 Penicillin-binding protein 1A pbpA 0.0106
26 Vascular endothelial growth factor receptor 3 FLT4 0.0106
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0105
737 Mineralocorticoid receptor NR3C2 0.0105
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0104
482 Glycine receptor subunit alpha-1 GLRA1 0.0104
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0103
1130 Lithostathine 1 alpha REG1A 0.0102
4542 Glutaminase 1 glsA1 0.0102
4544 Glutaminase 1 glsA1 0.0102
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0102
6020 Aldehyde oxidase AOX1 0.0102
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0102
6149 Solute carrier family 22 member 10 SLC22A10 0.0101
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0101
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0101
32 Vascular endothelial growth factor receptor 1 FLT1 0.0101
543 Penicillin-binding protein 1B mrcB 0.0101
6186 Penicillin-binding protein 1B ponB 0.0101
6822 Penicillin-binding protein 1b pbp1b 0.0101
6844 Penicillin-binding protein 1b pbp1b 0.0101
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.01
952 Dipeptidyl peptidase 4 DPP4 0.01
1 Peptidoglycan synthetase ftsI ftsI 0.0099
4155 Peptidoglycan synthetase ftsI ftsI 0.0099
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0099
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0098
474 Acetylcholinesterase ACHE 0.0098
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0098
2207 Rhodopsin RHO 0.0097
5787 Angiopoietin-1 receptor TEK 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
705 Glutamate receptor 1 GRIA1 0.0097
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0096
185 Vasopressin V1a receptor AVPR1A 0.0096
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0096
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0096
4318 Siroheme synthase cysG 0.0096
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0095
558 Solute carrier family 12 member 1 SLC12A1 0.0095
1439 Lactotransferrin LTF 0.0095
3119 Fimbrial protein pilE1 0.0095
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0095
566 Serotransferrin TF 0.0094
322 Vasopressin V2 receptor AVPR2 0.0094
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0094
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0091
1405 Thiopurine S-methyltransferase TPMT 0.009
537 ATP synthase delta chain, mitochondrial ATP5D 0.009
869 Estrogen receptor beta ESR2 0.0089
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0089
3453 Alkaline phosphatase phoA 0.0089
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
1721 Glycogen synthase kinase-3 beta GSK3B 0.0088
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0088
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0088
768 FK506-binding protein 1A FKBP1A 0.0088
723 Cytosolic phospholipase A2 PLA2G4A 0.0088
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0088
3917 Methylenetetrahydrofolate reductase MTHFR 0.0087
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0087
163 D(1B) dopamine receptor DRD5 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
94 5-hydroxytryptamine 4 receptor HTR4 0.0086
459 Retinoic acid receptor RXR-alpha RXRA 0.0086
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0086
5150 Endo-1,4-beta-xylanase Y xynY 0.0086
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0086
2503 Phosphomannomutase/phosphoglucomutase algC 0.0085
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0085
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0085
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0085
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0085
1650 Heme carrier protein 1 SLC46A1 0.0084
716 5-hydroxytryptamine 7 receptor HTR7 0.0084
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0084
165 FL cytokine receptor FLT3 0.0083
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0083
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0083
33 Cystine/glutamate transporter SLC7A11 0.0083
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0082
29 Tubulin beta-1 chain TUBB1 0.0081
1618 High affinity nerve growth factor receptor NTRK1 0.0081
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
130 Prostacyclin synthase PTGIS 0.0081
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0079
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0078
3932 Glutathione S-transferase A2 GSTA2 0.0078
2981 Phospholipase A2, membrane associated PLA2G2A 0.0077
295 Carbonic anhydrase 1 CA1 0.0077
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0077
161 Tubulin beta chain TUBB 0.0076
312 Tubulin beta chain TUB2 0.0076
703 NADPH azoreductase azr 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
124 Histamine H2 receptor HRH2 0.0075
5816 Cadherin-5 CDH5 0.0075
3810 Catechol O-methyltransferase COMT 0.0075
115 Penicillin-binding protein 2 mrdA 0.0075
6069 Penicillin-binding protein 2 mrdA 0.0075
6118 Penicillin-binding protein 2 penA 0.0075
6187 Penicillin-binding protein 2 pbpA 0.0075
6686 Penicillin-binding protein 2 pbp2 0.0075
6939 Penicillin-binding protein 2 mrdA 0.0075
7163 Penicillin-binding protein 2 pbpA 0.0075
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0075
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0074
1541 Metalloproteinase mmp20 0.0074
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0073
592 Carbonic anhydrase 4 CA4 0.0073
88 Retinoic acid receptor RXR-beta RXRB 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
3823 Cytokine receptor common gamma chain IL2RG 0.0073
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0072
342 P protein [Includes: DNA-directed DNA polymerase P 0.0072
612 P protein [Includes: DNA-directed DNA polymerase P 0.0072
4203 Histamine N-methyltransferase HNMT 0.0071
850 Vasopressin V1b receptor AVPR1B 0.007
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0069
49 Endothelin B receptor EDNRB 0.0069
4120 NADPH--cytochrome P450 reductase POR 0.0069
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0068
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0068
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0068
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0068
2853 14 kDa fatty acid-binding protein Not Available 0.0068
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0068
2112 Toll-like receptor 9 TLR9 0.0068
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0068
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0068
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0067
10 Glycogen phosphorylase, liver form PYGL 0.0067
293 Gamma-glutamyl hydrolase GGH 0.0067
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0067
1256 5-hydroxytryptamine 6 receptor HTR6 0.0066
36 Insulin receptor INSR 0.0066
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0066
2021 Thrombomodulin THBD 0.0066
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0065
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0065
1198 Serum paraoxonase/arylesterase 1 PON1 0.0065
2240 Cell division protein kinase 2 CDK2 0.0065
6223 Penicillin-binding protein 1C pbpC 0.0065
1275 Estrogen sulfotransferase SULT1E1 0.0064
661 ADP/ATP translocase 1 SLC25A4 0.0064
357 Carbonic anhydrase 2 CA2 0.0064
4217 Telomerase reverse transcriptase TERT 0.0064
489 Monocarboxylate transporter 2 SLC16A7 0.0064
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0063
6014 Cytochrome P450 2A13 CYP2A13 0.0063
724 Interleukin-2 receptor alpha chain IL2RA 0.0063
717 Interleukin-2 receptor subunit beta IL2RB 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0063
133 Dihydropterate synthase sulI 0.0063
6432 Transporter snf 0.0062
5482 Sialidase-2 NEU2 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
273 Apoptosis regulator Bcl-2 BCL2 0.0062
3957 Adenosine deaminase ADA 0.0062
3685 Catabolite gene activator crp 0.0061
4655 Adenylate cyclase cyaC 0.0061
4759 Adenylate cyclase cyaB2 0.0061
904 Glutathione S-transferase P GSTP1 0.0061
1010 Cytochrome P450 51A1 CYP51A1 0.0061
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0061
6012 Tryptophan 2,3-dioxygenase TDO2 0.0061
823 Fibroblast growth factor receptor 2 FGFR2 0.0061
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
4226 Uridine phosphorylase 2 UPP2 0.006
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.006
6103 Arylamine N-acetyltransferase 1 NAT1 0.0059
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0059
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0059
528 5-hydroxytryptamine 1E receptor HTR1E 0.0059
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0059
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0059
818 50S ribosomal protein L10 rplJ 0.0058
6167 Organic solute transporter subunit beta OSTB 0.0058
6166 Organic solute transporter subunit alpha OSTA 0.0058
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0058
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
828 Phenylalanine-4-hydroxylase PAH 0.0058
3109 Phenylalanine-4-hydroxylase phhA 0.0058
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0057
3639 Thymidine phosphorylase deoA 0.0056
3936 Thymidine phosphorylase TYMP 0.0056
1629 Transcription factor AP-1 JUN 0.0056
780 Retinoic acid receptor RXR-gamma RXRG 0.0056
427 Substance-P receptor TACR1 0.0056
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0055
4225 Uridine phosphorylase 1 UPP1 0.0055
6506 Stathmin-4 STMN4 0.0055
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0055
814 Ryanodine receptor 1 RYR1 0.0054
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
856 Vitamin D3 receptor VDR 0.0054
1152 Glycogen phosphorylase, muscle form PYGM 0.0054
594 Thyroxine-binding globulin SERPINA7 0.0053
1178 Adenosine A2a receptor ADORA2A 0.0053
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0052
4760 Mll3241 protein mll3241 0.0052
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0052
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0052
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0052
413 Amidophosphoribosyltransferase PPAT 0.0052
2515 Amidophosphoribosyltransferase purF 0.0052
3714 Amidophosphoribosyltransferase purF 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
4132 Chloride channel protein ClC-Ka CLCNKA 0.0051
1192 Sulfotransferase 1A1 SULT1A1 0.0051
291 Nitric-oxide synthase, endothelial NOS3 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
1714 Mitogen-activated protein kinase 3 MAPK3 0.005
3808 Dihydropteroate synthase 2 folP2 0.005
3601 Dihydropteroate synthase 1 folP1 0.005
3807 Dihydropteroate synthase 1 folP1 0.005
718 Folate receptor gamma FOLR3 0.005
299 Folate receptor beta FOLR2 0.005
804 Mitochondrial folate transporter/carrier SLC25A32 0.005
2320 Thymidine kinase, cytosolic TK1 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
518 Peroxidase/catalase T katG 0.0049
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0049
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0049
758 Thyroid hormone receptor alpha THRA 0.0049
173 Toll-like receptor 7 TLR7 0.0049
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0049
1992 Vitamin D-binding protein GC 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
162 Retinoic acid receptor gamma-1 RARG 0.0048
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0048
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0048
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0047
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0047
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0047
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0047
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0047
4773 Deoxycytidine kinase DCK 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
6126 Carbonic anhydrase 7 CA7 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
908 Glutathione S-transferase theta-1 GSTT1 0.0046
4122 Histone deacetylase 2 HDAC2 0.0045
1792 Tissue-type plasminogen activator PLAT 0.0045
527 Prostacyclin receptor PTGIR 0.0045
3086 Plasmepsin-2 Not Available 0.0045
1864 RET proto-oncogene RET 0.0045
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0045
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0045
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0045
16 Adenosine A1 receptor ADORA1 0.0045
6171 Solute carrier family 28 member 3 SLC28A3 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
6218 Pannexin-1 PANX1 0.0044
346 Thyroid hormone receptor beta-1 THRB 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0043
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0043
3809 Estrogen-related receptor gamma ESRRG 0.0043
633 Penicillin-binding proteins 1A/1B pbpA 0.0043
6042 Prostaglandin reductase 2 PTGR2 0.0043
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0042
6500 Phospholipase A2 PLA2G1B 0.0042
1313 Lactoylglutathione lyase GLO1 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0041
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0041
6677 Myelin P2 protein PMP2 0.0041
581 Cytochrome P450 2R1 CYP2R1 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6146 High affinity copper uptake protein 1 SLC31A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
730 Retinoic acid receptor alpha RARA 0.004
921 Glutamate receptor 2 GRIA2 0.004
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.004
4210 Toll-like receptor 4 TLR4 0.0039
6138 Multidrug resistance protein 3 ABCB4 0.0039
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
174 Sigma 1-type opioid receptor SIGMAR1 0.0038
751 Potassium channel subfamily K member 6 KCNK6 0.0038
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0037
3856 Fibroblast growth factor receptor 3 FGFR3 0.0037
284 DNA-directed RNA polymerase beta chain rpoB 0.0037
5773 DNA-directed RNA polymerase beta chain rpoB 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
54 Prothrombin F2 0.0037
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0037
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0036
1291 cAMP response element-binding protein CREB1 0.0036
5934 Cytochrome P450 26A1 CYP26A1 0.0036
199 Monocarboxylate transporter 8 SLC16A2 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
4237 50S ribosomal protein L22 rplV 0.0035
2539 Tubulin alpha-1 chain TUBA4A 0.0035
172 Potassium channel subfamily K member 1 KCNK1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0034
5300 Antigen peptide transporter 1 TAP1 0.0034
6501 Fatty acid-binding protein, liver FABP1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
153 Dopamine beta-hydroxylase DBH 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0033
5880 Thrombopoietin receptor MPL 0.0033
3587 Gastrotropin FABP6 0.0033
822 Aldose reductase AKR1B1 0.0033
4311 tRNA TRDMT1 0.0032
4325 tRNA trmD 0.0032
4328 tRNA trmD 0.0032
164 Histamine H4 receptor HRH4 0.0032
707 72 kDa type IV collagenase MMP2 0.0032
759 Free fatty acid receptor 1 FFAR1 0.0032
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0032
1867 Major prion protein PRNP 0.0032
6174 50S ribosomal protein L32 rpmF 0.0032
595 Fibrinogen alpha chain FGA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
84 Nuclear receptor 0B1 NR0B1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
469 Annexin A1 ANXA1 0.003
215 Sodium channel protein type 11 subunit alpha SCN11A 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0029
244 Angiotensin-converting enzyme ACE 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
319 Opioid receptor, sigma 1 OPRS1 0.0029
896 Glutathione S-transferase Mu 1 GSTM1 0.0029
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3937 Fatty-acid amide hydrolase FAAH 0.0028
2236 Casein kinase II subunit alpha CSNK2A1 0.0028
1053 BC269730_2 FADS1 0.0028
1395 Sodium/calcium exchanger 1 SLC8A1 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
1525 Heparin-binding growth factor 2 FGF2 0.0028
5431 Lipid binding protein Not Available 0.0028
3616 Fatty acid-binding protein, epidermal FABP5 0.0028
5433 UPF0230 protein TM_1468 TM_1468 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
65 Matrix metalloproteinase-9 Not Available 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
976 Platelet glycoprotein IX GP9 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
5818 Folate receptor alpha FOLR1 0.0027
1630 Integrin beta-2 ITGB2 0.0027
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
702 UMP-CMP kinase CMPK1 0.0027
239 Coagulation factor X F10 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
4192 DNA topoisomerase 2-beta TOP2B 0.0026
1360 Sphingomyelin phosphodiesterase SMPD1 0.0026
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0026
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0026
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0026
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0026
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
563 Thyroid peroxidase TPO 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
3426 Glutamine synthetase glnA 0.0025
3987 Glutamine synthetase GLUL 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0024
310 Solute carrier family 12 member 2 SLC12A2 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0024
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6048 Troponin C, skeletal muscle TNNC2 0.0023
7 Nitric oxide synthase, inducible NOS2 0.0023
283 SEC14-like protein 2 SEC14L2 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
6151 Monocarboxylate transporter 10 SLC16A10 0.0023
1341 Histamine H3 receptor HRH3 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
2782 Complement C1s subcomponent C1S 0.0022
6459 Glycodelin PAEP 0.0022
6044 Serum paraoxonase/lactonase 3 PON3 0.0022
3404 Exotoxin A eta 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
4041 Microsomal glutathione S-transferase 2 MGST2 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
572 Integrin alpha-L ITGAL 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
3814 Complement C1r subcomponent C1R 0.0021
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0021
1268 Neuropeptide S receptor NPSR1 0.002
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.002
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.002
3868 Calcineurin subunit B isoform 2 PPP3R2 0.002
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.002
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
2216 Fibroblast growth factor receptor 4 FGFR4 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
106 Cannabinoid receptor 2 CNR2 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
605 Fumarate reductase flavoprotein subunit frdA 0.0016
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0016
3673 Fumarate reductase flavoprotein subunit fccA 0.0016
4912 Fumarate reductase flavoprotein subunit ifcA 0.0016
6549 Fumarate reductase flavoprotein subunit frdA 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
4031 Glutathione S-transferase A1 GSTA1 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0016
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0016
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3233 Bile acid receptor NR1H4 0.0015
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
4948 Cytochrome c-553 Not Available 0.0015
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
4923 Cytochrome c3 DvMF_2499 0.0015
4945 Cytochrome c3 Not Available 0.0015
4949 Cytochrome c3 DVU_3171 0.0015
4968 Cytochrome c3 cytc3 0.0015
4997 Cytochrome c3 SO_2727 0.0015
5219 Cytochrome c3 cyd 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
3189 High-molecular-weight cytochrome c hmcA 0.0015
4902 Nine-heme cytochrome c Ddes_2038 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0015
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
611 Retinal dehydrogenase 1 ALDH1A1 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
1039 Histone deacetylase 9 HDAC9 0.0013
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0013
4386 Hemoglobin-like protein HbN glbN 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
4943 Cytochrome c6 petJ 0.0013
4954 Soluble cytochrome b558 Not Available 0.0013
4947 Bacterial hemoglobin vhb 0.0013
4916 Cyanoglobin glbN 0.0013
4984 Neuroglobin NGB 0.0013
4934 Cytochrome c-551 nirM 0.0013
5218 Cytochrome c-551 nirM 0.0013
4905 Cytochrome c2 Not Available 0.0013
4939 Cytochrome c2 cycA 0.0013
4964 Cytochrome c2 cycA 0.0013
4979 Cytochrome c2 cycA 0.0013
6673 Cytochrome c2 cycA 0.0013
4925 Cytochrome c-type protein SHP shp 0.0013
4994 Hemoglobin-like protein HbO glbO 0.0013
4942 Diheme cytochrome c napB napB 0.0013
4998 Hemoglobin-like protein yjbI yjbI 0.0013
4915 Cytochrome c-550 psbV 0.0013
4959 Cytochrome c-550 psbV 0.0013
5216 Cytochrome c-550 psbV 0.0013
4936 Cytochrome c2 iso-2 Not Available 0.0013
4975 Cytochrome c-556 RPA3973 0.0013
5000 HemO hemO 0.0013
4910 Cytoglobin CYGB 0.0013
4961 Hemophore HasA hasA 0.0013
4981 Iron-starvation protein PigA pigA 0.0013
4904 Cytochrome c family protein GSU1996 0.0013
3116 Bacterioferritin bfr 0.0013
4906 Bacterioferritin bfr 0.0013
4965 Bacterioferritin bfr 0.0013
644 Heme oxygenase 2 HMOX2 0.0013
4982 Heme oxygenase 2 pbsA2 0.0013
4935 Cytochrome c-554 cycA1 0.0013
4909 CooA protein cooA 0.0013
4971 Nonaheme cytochrome c hmcA 0.0013
4907 Cytochrome c-L moxG 0.0013
6865 Cytochrome c-L moxG 0.0013
4764 Cytochrome P450 165C4 CYP165C4 0.0013
4989 Cytochrome c551 peroxidase ccp 0.0013
5222 Cytochrome c551 peroxidase ccpA 0.0013
4937 Cytochrome oxidase subunit II rcoxA 0.0013
4976 Apocytochrome f petA 0.0013
6407 Apocytochrome f petA 0.0013
4931 Cytochrome P450 167A1 CYP167A1 0.0013
4999 Cytochrome P450 165B3 CYP165B3 0.0013
4960 Putative cytochrome P450-family protein SCO7417 0.0013
4922 Cytochrome c, putative SO_4144 0.0013
4926 Heme-based aerotactic transducer hemAT hemAT 0.0013
4903 Methyl-accepting chemotaxis protein Tar4 0.0013
4993 Hydroxylamine oxidoreductase hao1 0.0013
4972 P450cin cinA 0.0013
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0013
4952 Catalase/peroxidase katA 0.0013
3093 Catalase HPII katE 0.0013
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0013
4034 Glutaredoxin-1 GLRX 0.0013
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0013
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0013
910 Epididymal secretory glutathione peroxidase GPX5 0.0013
4036 Glutathione peroxidase 6 GPX6 0.0013
903 Glutathione S-transferase A5 GSTA5 0.0013
911 Glutathione peroxidase 3 GPX3 0.0013
4037 Hypothetical protein GPX1 0.0013
4297 Hypothetical protein SP_1951 0.0013
4521 Hypothetical protein BC_2969 0.0013
4540 Hypothetical protein TM_1070 0.0013
4555 Hypothetical protein MT1739 0.0013
4569 Hypothetical protein mshD 0.0013
4578 Hypothetical protein PA3270 0.0013
4747 Hypothetical protein PA3967 0.0013
5177 Hypothetical protein TM_0096 0.0013
5194 Hypothetical protein PA1204 0.0013
5240 Hypothetical protein Rv2991 0.0013
5370 Hypothetical protein TM_1158 0.0013
5710 Hypothetical protein Tb927.5.1360 0.0013
1928 Leukotriene C4 synthase LTC4S 0.0013
4029 Microsomal glutathione S-transferase 3 MGST3 0.0013
4032 Microsomal glutathione S-transferase 1 MGST1 0.0013
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0013
4040 Glutathione peroxidase 7 GPX7 0.0013
907 Glutathione peroxidase 2 GPX2 0.0013
906 Glutathione peroxidase 1 GPX1 0.0013
4035 Glutathione S-transferase Mu 5 GSTM5 0.0013
900 Glutathione S-transferase A4 GSTA4 0.0013
4042 Glutathione transferase omega-2 GSTO2 0.0013
4033 S-formylglutathione hydrolase ESD 0.0013
4038 Glutathione peroxidase 4 GPX4 0.0013
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0013
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
3221 Cytochrome c4 cc4 0.0012
1295 Fatty acid synthase FASN 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
2298 Cytochrome P450-cam camC 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
3319 Hydroxyacylglutathione hydrolase HAGH 0.0011
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0011
897 Glutathione S-transferase kappa 1 GSTK1 0.0011
898 Glutathione S-transferase A3 GSTA3 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
909 Maleylacetoacetate isomerase GSTZ1 0.0011
899 Glutathione S-transferase Mu 3 GSTM3 0.0011
905 Glutathione transferase omega-1 GSTO1 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
1507 Cytochrome c CYCS 0.001
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
734 D1 dopamine receptor-interacting protein calcyon CALY 0.001
2165 Glutathione S-transferase Mu 2 GSTM2 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
207 Glutathione synthetase GSS 0.001
5269 Glutathione synthetase gshB 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
4920 Peroxidase/catalase katG 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
2119 Cytochrome b5 CYB5A 0.0009
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0009
4990 PpcA ppcA 0.0009
4988 Sulfite oxidase, mitochondrial SUOX 0.0009
3570 Cytochrome P450 152A1 cypC 0.0009
4289 Cytochrome P450 TT_P0059 0.0009
6262 Cytochrome P450 staP 0.0009
3375 Acidic cytochrome c3 Not Available 0.0009
4992 Cytochrome c peroxidase Not Available 0.0009
2915 Sensor protein fixL fixL 0.0009
4944 Sensor protein fixL fixL 0.0009
4813 Heme oxygenase hmuO 0.0009
5769 Heme oxygenase Not Available 0.0009
4385 Cytochrome c' Not Available 0.0009
4967 Cytochrome c' cycA 0.0009
5038 Cytochrome c' Not Available 0.0009
5223 Cytochrome c' cycP 0.0009
901 Glutathione S-transferase Mu 4 GSTM4 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
2230 Catalase CAT 0.0009
3249 Catalase katA 0.0009
3625 Catalase katA 0.0009
4539 Catalase katA 0.0009
4941 Catalase katB 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3670 Soluble cytochrome b562 precursor cybC 0.0008
3411 Cytochrome P450 121 cyp121 0.0008
2617 Nitric oxide synthase oxygenase nos 0.0008
2701 Nitric oxide synthase oxygenase nos 0.0008
714 Glutathione reductase, mitochondrial GSR 0.0008
3291 Cytochrome c-552 cycA 0.0008
4927 Cytochrome c-552 nrfA 0.0008
4938 Cytochrome c-552 cycA 0.0008
4953 Cytochrome c-552 nrfA 0.0008
5217 Cytochrome c-552 cycM 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
2972 6-deoxyerythronolide B hydroxylase eryF 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
4608 Putative cytochrome P450 SCO1207 0.0007
4963 Putative cytochrome P450 SCO2884 0.0007
6254 Putative cytochrome P450 SCO6998 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
125 DNA polymerase beta POLB 0.0007
358 Cystathionine beta-synthase CBS 0.0006
693 Hemoglobin subunit beta HBB 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6268 Hydroxyacid oxidase 1 HAO1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6749 Polyprotein Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
5961 Insulin INS 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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