DT-Web

DB00373 - Timolol


Identification
Name Timolol
Accession Number DB00373 (APRD00229, DB08625)
Type small molecule
Description A beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 316.42
Groups approved
Monoisotopic Weight 316.156911344
Pharmacology
Indication In its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma.
Mechanism of action Like propranolol and nadolol, timolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta(2)-blockade results in an increase in peripheral vascular resistance. The exact mechanism whereby timolol reduces ocular pressure is still not known. The most likely action is by decreasing the secretion of aqueous humor.
Absorption Bioavailability is about 60%
Protein binding ~10%
Biotransformation Primarily hepatic (80%) via the cytochrome P450 2D6 isoenzyme.
Route of elimination Timolol and its metabolites are primarily excreted in the urine.
Toxicity LD50=1190 mg/kg (oral, mice), LD50=900 mg/kg (oral, rat). Symptoms of overdose include drowsiness, vertigo, headache, and atriventricular block.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetohexamide The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Aminophylline Antagonism of action and increased effect of theophylline
Celecoxib The NSAID, Celecoxib, may antagonize the antihypertensive effect of Timolol.
Chlorpropamide The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Cimetidine Cimetidine may increase the serum concentration of timolol by decreasing its metabolism.
Clonidine Increased hypertension when clonidine stopped
Diclofenac The NSAID, Diclofenac, may antagonize the antihypertensive effect of Timolol.
Diflunisal The NSAID, Diflunisal, may antagonize the antihypertensive effect of Timolol.
Dihydroergotamine Ischemia with risk of gangrene
Dihydroergotoxine Ischemia with risk of gangrene
Diltiazem Additive effects of decreased heart rate and contractility may occur. Increased risk of heart block.
Disopyramide The beta-blocker, timolol, may increase the toxicity of disopyramide.
Dyphylline Antagonism of action and increased effect of theophylline
Epinephrine Hypertension, then bradycardia
Ergonovine Ischemia with risk of gangrene
Ergotamine Ischemia with risk of gangrene
Etodolac The NSAID, Etodolac, may antagonize the antihypertensive effect of Timolol.
Fenoprofen The NSAID, Fenoprofen, may antagonize the antihypertensive effect of Timolol.
Fenoterol Antagonism
Flurbiprofen The NSAID, Flurbiprofen, may antagonize the antihypertensive effect of Timolol.
Formoterol Antagonism
Gliclazide The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Glipizide The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Glisoxepide The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Glyburide The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Glycodiazine The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Indomethacin Risk of inhibition of renal prostaglandins
Insulin Glargine The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
insulin inhaled The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Isoproterenol Antagonism
Ketoprofen The NSAID, Ketoprofen, may antagonize the antihypertensive effect of Timolol.
Ketorolac The NSAID, Ketorolac, may antagonize the antihypertensive effect of Timolol.
Lidocaine The beta-blocker, timolol, may increase the effect and toxicity of lidocaine.
Lumiracoxib The NSAID, Lumiracoxib, may antagonize the antihypertensive effect of Timolol.
Meclofenamic acid The NSAID, Meclofenamate, may antagonize the antihypertensive effect of Timolol.
Meloxicam The NSAID, Meloxicam, may antagonize the antihypertensive effect of Timolol.
Methyldopa Possible hypertensive crisis
Methysergide Ischemia with risk of gangrene
Nabumetone The NSAID, Nabumetone, may antagonize the antihypertensive effect of Timolol.
Naproxen The NSAID, Naproxen, may antagonize the antihypertensive effect of Timolol.
Orciprenaline Antagonism
Oxaprozin The NSAID, Oxaprozin, may antagonize the antihypertensive effect of Timolol.
Oxtriphylline Antagonism of action and increased effect of theophylline
Pipobroman Antagonism
Pirbuterol Antagonism
Piroxicam Risk of inhibition of renal prostaglandins
Prazosin Risk of hypotension at the beginning of therapy
Procaterol Antagonism
Repaglinide The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Salbutamol Antagonism
Salmeterol Antagonism
Sulindac The NSAID, Sulindac, may antagonize the antihypertensive effect of Timolol.
Terazosin Increased risk of hypotension. Initiate concomitant therapy cautiously.
Terbinafine Terbinafine may reduce the metabolism and clearance of Timolol. Consider alternate therapy or monitor for therapeutic/adverse effects of Amytriptyline if Timolol is initiated, discontinued or dose changed.
Terbutaline Antagonism
Theophylline Antagonism of action and increased effect of theophylline
Tiaprofenic acid The NSAID, Tiaprofenic acid, may antagonize the antihypertensive effect of Timolol.
Tolazamide The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Tolbutamide The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Tolmetin The NSAID, Tolmetin, may antagonize the antihypertensive effect of Timolol.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Verapamil Additive effects of decreased heart rate and contractility may occur. Increased risk of heart block.
Food Interactions Not Available

Targets


Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Nieminen T, Uusitalo H, Maenpaa J, Turjanmaa V, Rane A, Lundgren S, Ropo A, Rontu R, Lehtimaki T, Kahonen M: Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study. Eur J Clin Pharmacol. 2005 Dec;61(11):811-9. Epub 2005 Nov 17. - Pubmed
  • Varma DR, Shen H, Deng XF, Peri KG, Chemtob S, Mulay S: Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium. Br J Pharmacol. 1999 Jun;127(4):895-902. - Pubmed
  • Hirooka K, Kelly ME, Baldridge WH, Barnes S: Suppressive actions of betaxolol on ionic currents in retinal ganglion cells may explain its neuroprotective effects. Exp Eye Res. 2000 May;70(5):611-21. - Pubmed
  • Bhattacharyya BJ, Lee E, Krupin D, Hockberger P, Krupin T: (-)-Isoproterenol modulation of maxi-K(+) channel in nonpigmented ciliary epithelial cells through a G-protein gated pathway. Curr Eye Res. 2002 Mar;24(3):173-81. - Pubmed
  • Wang T, Kaumann AJ, Brown MJ: (--)-Timolol is a more potent antagonist of the positive inotropic effects of (--)-adrenaline than of those of (--)-noradrenaline in human atrium. Br J Clin Pharmacol. 1996 Aug;42(2):217-23. - Pubmed
DTHybrid score 0.7218
Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Fuchsjager-Mayrl G, Markovic O, Losert D, Lucas T, Wachek V, Muller M, Schmetterer L: Polymorphism of the beta-2 adrenoceptor and IOP lowering potency of topical timolol in healthy subjects. Mol Vis. 2005 Sep 23;11:811-5. - Pubmed
  • Rotmensch HH, Vlasses PH, Feinberg JA, Abrams WB, Ferguson RK: Comparisons of beta-adrenergic blocking properties of S- and R-timolol in humans. J Clin Pharmacol. 1993 Jun;33(6):544-8. - Pubmed
  • Borger P, Hoekstra Y, Esselink MT, Postma DS, Zaagsma J, Vellenga E, Kauffman HF: Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype. Am J Respir Cell Mol Biol. 1998 Sep;19(3):400-7. - Pubmed
  • Van der Graaf PH, Saxena PR, Shankley NP, Black JW: Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries. Br J Pharmacol. 1995 Dec;116(8):3237-42. - Pubmed
  • Ferro A, Hall JA, Dickerson JE, Brown MJ: A prospective study of the effects of prolonged timolol therapy on alpha- and beta-adrenoceptor and angiotensin II receptor mediated responses in normal subjects. Br J Clin Pharmacol. 1997 Mar;43(3):301-8. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7484
Lysozyme
Name Lysozyme
Gene Name E
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.5147

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4177
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2641

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Terao T, Hisanaga E, Sai Y, Tamai I, Tsuji A: Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J Pharm Pharmacol. 1996 Oct;48(10):1083-9. - Pubmed
DTHybrid score 0.3241

Predictions


Id Partner name Gene Name Score
3633 Lysozyme R 1.5147
5597 Lysozyme 17 1.5147
4512 Cytochrome P450 3A4 CYP3A4 0.2607
4757 Cytochrome P450 2C9 CYP2C9 0.1692
4200 Cytochrome P450 1A2 CYP1A2 0.1481
1517 Beta-3 adrenergic receptor ADRB3 0.1385
4924 Cytochrome P450 2C8 CYP2C8 0.1071
4118 Cytochrome P450 3A5 CYP3A5 0.1058
556 Alpha-1A adrenergic receptor ADRA1A 0.0905
6030 Cytochrome P450 2B6 CYP2B6 0.079
6107 Cytochrome P450 3A7 CYP3A7 0.078
320 5-hydroxytryptamine 1A receptor HTR1A 0.0713
6013 Cytochrome P450 2E1 CYP2E1 0.0678
6024 Cytochrome P450 1A1 CYP1A1 0.0671
6144 Solute carrier family 22 member 2 SLC22A2 0.0597
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0549
824 Sodium-dependent serotonin transporter SLC6A4 0.0547
5718 Cytochrome P450 2A6 CYP2A6 0.0531
318 Alpha-2A adrenergic receptor ADRA2A 0.0526
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0517
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.05
6145 Solute carrier family 22 member 1 SLC22A1 0.049
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0487
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0473
492 Histamine H1 receptor HRH1 0.047
587 Serum albumin ALB 0.0428
3923 Cholinesterase BCHE 0.0422
632 Alpha-1B adrenergic receptor ADRA1B 0.0414
885 5-hydroxytryptamine 1B receptor HTR1B 0.0405
831 D(2) dopamine receptor DRD2 0.0343
713 Sodium-dependent dopamine transporter SLC6A3 0.0332
502 5-hydroxytryptamine 2A receptor HTR2A 0.0326
629 Alpha-2B adrenergic receptor ADRA2B 0.0321
4031 Glutathione S-transferase A1 GSTA1 0.0315
3941 Amine oxidase [flavin-containing] A MAOA 0.0312
20 Prostaglandin G/H synthase 1 PTGS1 0.031
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0307
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0306
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0298
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0295
6106 Cytochrome P450 2C18 CYP2C18 0.0292
118 Organic cation/carnitine transporter 2 SLC22A5 0.0287
862 Multidrug resistance-associated protein 1 ABCC1 0.0269
378 Alpha-2C adrenergic receptor ADRA2C 0.0267
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0256
789 Alpha-1D adrenergic receptor ADRA1D 0.0255
23 D(1A) dopamine receptor DRD1 0.0255
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0251
2457 Bacillolysin nprS 0.0231
3810 Catechol O-methyltransferase COMT 0.0227
6147 Solute carrier family 22 member 3 SLC22A3 0.0214
1729 Solute carrier family 22 member 6 SLC22A6 0.0203
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0202
590 5-hydroxytryptamine 2C receptor HTR2C 0.0198
871 Glucocorticoid receptor NR3C1 0.0187
4615 Chain A, Red Copper Protein Nitrosocyanin NE0143 0.0187
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0185
4681 Aminopeptidase Not Available 0.018
3526 Pseudomonalisin pcp 0.018
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0178
847 Mu-type opioid receptor OPRM1 0.0177
777 Tumor necrosis factor TNF 0.0175
3939 Amine oxidase [flavin-containing] B MAOB 0.0174
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0174
1898 Cytochrome P450 1B1 CYP1B1 0.0172
731 HIV-1 protease HIV-1 protease 0.0171
1820 Beta-nerve growth factor NGF 0.0166
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0165
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0165
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0162
833 Organic cation/carnitine transporter 1 SLC22A4 0.0162
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0162
465 Calmodulin CALM1 0.0162
776 Bile salt export pump ABCB11 0.0161
952 Dipeptidyl peptidase 4 DPP4 0.0161
638 D(3) dopamine receptor DRD3 0.0156
3811 Cytochrome P450 19A1 CYP19A1 0.0153
6142 Solute carrier family 22 member 8 SLC22A8 0.0152
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0152
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0151
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0151
467 Delta-type opioid receptor OPRD1 0.0149
828 Phenylalanine-4-hydroxylase PAH 0.0149
3109 Phenylalanine-4-hydroxylase phhA 0.0149
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0148
6231 Pepsin A PGA3 0.0147
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0145
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0145
260 Cytochrome P450 51 ERG11 0.0144
761 Cytochrome P450 51 ERG11 0.0144
3163 Cytochrome P450 51 cyp51 0.0144
696 Kappa-type opioid receptor OPRK1 0.0143
124 Histamine H2 receptor HRH2 0.0141
5226 Protein ninB ninB 0.014
436 5-hydroxytryptamine 2B receptor HTR2B 0.0136
1758 GTPase HRas HRAS 0.0135
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0128
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0126
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0125
817 DNA topoisomerase 2-alpha TOP2A 0.0125
290 Prostaglandin G/H synthase 2 PTGS2 0.0124
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0122
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0122
1277 Alpha-1-antitrypsin SERPINA1 0.0122
3076 Antigen 85-C fbpC 0.0122
131 Synaptic vesicular amine transporter SLC18A2 0.0121
6182 Cytochrome P450 2J2 CYP2J2 0.0117
6500 Phospholipase A2 PLA2G1B 0.0116
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0114
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0113
432 D(4) dopamine receptor DRD4 0.0113
6143 Solute carrier family 22 member 7 SLC22A7 0.0112
341 5-hydroxytryptamine 3 receptor HTR3A 0.0112
2826 Glucose--fructose oxidoreductase gfo 0.0107
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0107
4549 Endonuclease III HP_0602 0.0106
136 Estrogen receptor ESR1 0.0102
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0101
725 5-hydroxytryptamine 1D receptor HTR1D 0.01
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0099
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0098
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0097
2164 Multidrug resistance-associated protein 4 ABCC4 0.0096
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0096
6847 Lactase-phlorizin hydrolase LCT 0.0093
716 5-hydroxytryptamine 7 receptor HTR7 0.0092
474 Acetylcholinesterase ACHE 0.0092
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0091
1313 Lactoylglutathione lyase GLO1 0.0091
844 Epidermal growth factor receptor EGFR 0.0091
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0089
146 Androgen receptor AR 0.0089
1176 Mitogen-activated protein kinase 1 MAPK1 0.0089
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0089
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0088
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0084
161 Tubulin beta chain TUBB 0.0084
312 Tubulin beta chain TUB2 0.0084
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0084
468 Cytochrome P450 4A11 CYP4A11 0.0083
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0083
4604 Liver carboxylesterase 1 CES1 0.0082
6031 Cytochrome P450 3A43 CYP3A43 0.0082
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0082
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0082
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0082
122 P2Y purinoceptor 12 P2RY12 0.0082
380 Cytochrome P450 17A1 CYP17A1 0.0081
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.008
183 Vascular endothelial growth factor A VEGFA 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0078
4120 NADPH--cytochrome P450 reductase POR 0.0076
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0075
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0074
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0074
1374 Natriuretic peptides B NPPB 0.0074
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0074
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0074
1827 Gap junction alpha-1 protein GJA1 0.0074
1908 Vascular cell adhesion protein 1 VCAM1 0.0074
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0073
6137 Multidrug resistance-associated protein 6 ABCC6 0.0072
1256 5-hydroxytryptamine 6 receptor HTR6 0.0072
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0072
244 Angiotensin-converting enzyme ACE 0.0071
504 Mast/stem cell growth factor receptor KIT 0.0071
6432 Transporter snf 0.0068
6148 Multidrug resistance-associated protein 7 ABCC10 0.0068
1192 Sulfotransferase 1A1 SULT1A1 0.0068
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0066
6141 Sodium/bile acid cotransporter SLC10A1 0.0066
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0066
3947 Xanthine dehydrogenase/oxidase XDH 0.0066
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0065
614 Progesterone receptor PGR 0.0065
163 D(1B) dopamine receptor DRD5 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0063
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0061
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0061
26 Vascular endothelial growth factor receptor 3 FLT4 0.0061
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.006
1656 CYP2B protein CYP2B 0.0058
70 Type-1 angiotensin II receptor AGTR1 0.0058
373 Transthyretin TTR 0.0058
5126 Arginase rocF 0.0058
32 Vascular endothelial growth factor receptor 1 FLT1 0.0058
624 Guanidinoacetate N-methyltransferase GAMT 0.0057
6136 Multidrug resistance-associated protein 5 ABCC5 0.0057
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0057
1024 Solute carrier family 22 member 11 SLC22A11 0.0057
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0056
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0056
2112 Toll-like receptor 9 TLR9 0.0055
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0055
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0054
407 Vascular endothelial growth factor receptor 2 KDR 0.0053
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0052
6151 Monocarboxylate transporter 10 SLC16A10 0.0052
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0052
228 Beta platelet-derived growth factor receptor PDGFRB 0.0051
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0051
869 Estrogen receptor beta ESR2 0.005
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.005
1360 Sphingomyelin phosphodiesterase SMPD1 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
756 Sex hormone-binding globulin SHBG 0.0048
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0048
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0048
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0048
528 5-hydroxytryptamine 1E receptor HTR1E 0.0047
5682 Ribonuclease pancreatic RNASE1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0046
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0046
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0046
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0045
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0045
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0044
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0044
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0043
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0043
1010 Cytochrome P450 51A1 CYP51A1 0.0043
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0042
738 Monocarboxylate transporter 1 SLC16A1 0.0042
365 Dihydrofolate reductase DHFR 0.0042
2381 Dihydrofolate reductase DFR1 0.0042
2833 Dihydrofolate reductase Not Available 0.0042
2931 Dihydrofolate reductase folA 0.0042
3544 Dihydrofolate reductase folA 0.0042
3682 Dihydrofolate reductase folA 0.0042
6642 Dihydrofolate reductase folA 0.0042
6756 Dihydrofolate reductase dfrA 0.0042
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0042
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0041
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0041
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0041
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0041
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0041
891 Dihydropteroate synthase folP 0.0041
5359 Dihydropteroate synthase folP 0.0041
7175 Dihydropteroate synthase sulI 0.0041
94 5-hydroxytryptamine 4 receptor HTR4 0.0041
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
319 Opioid receptor, sigma 1 OPRS1 0.004
6220 Aryl hydrocarbon receptor AHR 0.004
818 50S ribosomal protein L10 rplJ 0.0039
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0039
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0038
2539 Tubulin alpha-1 chain TUBA4A 0.0038
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0038
4103 Proteasome subunit beta type 2 PSMB2 0.0038
4102 Proteasome subunit beta type 5 PSMB5 0.0038
4101 Proteasome subunit beta type 1 PSMB1 0.0038
737 Mineralocorticoid receptor NR3C2 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0038
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0037
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0037
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0037
5300 Antigen peptide transporter 1 TAP1 0.0037
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0037
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0036
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0035
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0034
6014 Cytochrome P450 2A13 CYP2A13 0.0034
6506 Stathmin-4 STMN4 0.0033
174 Sigma 1-type opioid receptor SIGMAR1 0.0033
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0033
173 Toll-like receptor 7 TLR7 0.0033
6102 Arylamine N-acetyltransferase 2 NAT2 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0032
1178 Adenosine A2a receptor ADORA2A 0.0032
362 Melatonin receptor type 1B MTNR1B 0.0032
571 Melatonin receptor type 1A MTNR1A 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0031
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1618 High affinity nerve growth factor receptor NTRK1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0031
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0031
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.003
1629 Transcription factor AP-1 JUN 0.003
592 Carbonic anhydrase 4 CA4 0.003
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.003
4203 Histamine N-methyltransferase HNMT 0.0029
511 5-hydroxytryptamine 1F receptor HTR1F 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0029
683 Potassium transporter GK0582 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
427 Substance-P receptor TACR1 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0028
4311 tRNA TRDMT1 0.0028
4325 tRNA trmD 0.0028
4328 tRNA trmD 0.0028
823 Fibroblast growth factor receptor 2 FGFR2 0.0028
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0028
165 FL cytokine receptor FLT3 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0027
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0027
6085 Fatty acid-binding protein, intestinal FABP2 0.0027
1757 Myeloperoxidase MPO 0.0027
49 Endothelin B receptor EDNRB 0.0027
239 Coagulation factor X F10 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
921 Glutamate receptor 2 GRIA2 0.0026
85 Growth hormone receptor GHR 0.0025
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0025
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
904 Glutathione S-transferase P GSTP1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0025
578 Endothelin-1 receptor EDNRA 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0024
106 Cannabinoid receptor 2 CNR2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6174 50S ribosomal protein L32 rpmF 0.0023
518 Peroxidase/catalase T katG 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
295 Carbonic anhydrase 1 CA1 0.0023
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0023
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0023
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0022
811 Translocator protein TSPO 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
68 Cannabinoid receptor 1 CNR1 0.0022
357 Carbonic anhydrase 2 CA2 0.0022
6126 Carbonic anhydrase 7 CA7 0.0022
563 Thyroid peroxidase TPO 0.0022
976 Platelet glycoprotein IX GP9 0.0021
1630 Integrin beta-2 ITGB2 0.0021
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0021
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.002
144 Hemoglobin subunit alpha HBA1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
634 Squalene monooxygenase SQLE 0.002
7196 Squalene monooxygenase ERG1 0.002
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.002
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.002
4122 Histone deacetylase 2 HDAC2 0.0019
7 Nitric oxide synthase, inducible NOS2 0.0019
4773 Deoxycytidine kinase DCK 0.0019
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
1050 Bile salt sulfotransferase SULT2A1 0.0019
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0019
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0019
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0019
469 Annexin A1 ANXA1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
558 Solute carrier family 12 member 1 SLC12A1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0018
273 Apoptosis regulator Bcl-2 BCL2 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0018
5787 Angiopoietin-1 receptor TEK 0.0018
6044 Serum paraoxonase/lactonase 3 PON3 0.0017
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0017
6146 High affinity copper uptake protein 1 SLC31A1 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
3932 Glutathione S-transferase A2 GSTA2 0.0017
581 Cytochrome P450 2R1 CYP2R1 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0017
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0016
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0016
164 Histamine H4 receptor HRH4 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0016
572 Integrin alpha-L ITGAL 0.0016
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
1992 Vitamin D-binding protein GC 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
1864 RET proto-oncogene RET 0.0016
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0016
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0016
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0016
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0015
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0015
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0015
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0015
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0015
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0015
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0015
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0015
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0015
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
4217 Telomerase reverse transcriptase TERT 0.0014
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0014
3086 Plasmepsin-2 Not Available 0.0014
5934 Cytochrome P450 26A1 CYP26A1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
482 Glycine receptor subunit alpha-1 GLRA1 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
16 Adenosine A1 receptor ADORA1 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0014
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0014
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
3809 Estrogen-related receptor gamma ESRRG 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
3404 Exotoxin A eta 0.0013
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0013
3957 Adenosine deaminase ADA 0.0013
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0013
1196 Complement decay-accelerating factor CD55 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0013
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
814 Ryanodine receptor 1 RYR1 0.0012
694 Matrix protein 2 M 0.0012
84 Nuclear receptor 0B1 NR0B1 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2021 Thrombomodulin THBD 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0012
856 Vitamin D3 receptor VDR 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6859 Protein S100-A4 S100A4 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0011
5798 Mitogen-activated protein kinase 11 MAPK11 0.0011
2320 Thymidine kinase, cytosolic TK1 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
2808 Chloramphenicol acetyltransferase 3 cat3 0.0011
6459 Glycodelin PAEP 0.0011
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
3601 Dihydropteroate synthase 1 folP1 0.001
3807 Dihydropteroate synthase 1 folP1 0.001
3808 Dihydropteroate synthase 2 folP2 0.001
153 Dopamine beta-hydroxylase DBH 0.001
2417 Chloramphenicol acetyltransferase cat 0.001
3278 Chloramphenicol acetyltransferase cat 0.001
444 Alcohol dehydrogenase 1B ADH1B 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2810 Dr hemagglutinin structural subunit draA 0.001
6218 Pannexin-1 PANX1 0.001
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
3913 Glutamic acid decarboxylase GAD65 0.001
4192 DNA topoisomerase 2-beta TOP2B 0.001
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
3830 Calreticulin CALR 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
1275 Estrogen sulfotransferase SULT1E1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
760 Fibroblast growth factor 1 FGF1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
3937 Fatty-acid amide hydrolase FAAH 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
1483 Membrane copper amine oxidase AOC3 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
54 Prothrombin F2 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
1341 Histamine H3 receptor HRH3 0.0008
751 Potassium channel subfamily K member 6 KCNK6 0.0008
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
6043 Putative G-protein coupled receptor 44 GPR44 0.0008
2207 Rhodopsin RHO 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
735 Alanine aminotransferase 1 GPT 0.0008
3904 Alanine aminotransferase 2 GPT2 0.0008
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
908 Glutathione S-transferase theta-1 GSTT1 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
284 DNA-directed RNA polymerase beta chain rpoB 0.0008
5773 DNA-directed RNA polymerase beta chain rpoB 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
251 Alcohol dehydrogenase 1A ADH1A 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
820 Glycine receptor subunit alpha-2 GLRA2 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
267 Plasminogen activator inhibitor 1 SERPINE1 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
275 Arachidonate 5-lipoxygenase ALOX5 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6221 Steroid hormone receptor ERR1 ESRRA 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
1039 Histone deacetylase 9 HDAC9 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
6020 Aldehyde oxidase AOX1 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
6131 Carbonic anhydrase 14 CA14 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6122 Carbonic anhydrase 3 CA3 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
3007 Carbonic anhydrase 12 CA12 0.0003
4205 Carbonic anhydrase 9 CA9 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
↑