DT-Web

DB00938 - Salmeterol


Identification
Name Salmeterol
Accession Number DB00938 (APRD00277)
Type small molecule
Description Salmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 415.5656
Groups approved
Monoisotopic Weight 415.272258677
Pharmacology
Indication For the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Mechanism of action Salmeterol's long, lipophilic side chain binds to exosites near beta(2)-receptors in the lungs and on bronchiolar smooth muscle, allowing the active portion of the molecule to remain at the receptor site, continually binding and releasing. Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.
Absorption Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation of recommended doses.
Protein binding 96%
Biotransformation Hepatic, metabolized by hydroxylation via CYP3A4
Route of elimination Not Available
Toxicity Symptoms of overdose include angina (chest pain), dizziness, dry mouth, fatigue, flu-like symptoms, headache, heart irregularities, high or low blood pressure, high blood sugar, insomnia, muscle cramps, nausea, nervousness, rapid heartbeat, seizures, and tremor. By the oral route, no deaths occurred in rats at 1,000 mg/kg (approximately 81,000 times the maximum recommended daily inhalation dose in adults and approximately 38,000 times the maximum recommended daily inhalation dose in children on a mg/m2 basis).
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Antagonism
Atenolol Antagonism
Bisoprolol Antagonism
Carvedilol Antagonism
Conivaptan CYP3A4 Inhibitors (Strong) may increase the serum concentration of Salmeterol. Concurrent use of salmeterol with strong inhibitors of CYP3A4 is not recommended according to salmeterol prescribing information.
Esmolol Antagonism
Indacaterol Concomitant use with other inhaled, long acting beta2-adrenergic drugs may result in an overdose. Adverse cardiovascular effects and fatalities have been associated with excessive use of inhaled sympathomimetic drugs.
Labetalol Antagonism
Metoprolol Antagonism
Nadolol Antagonism
Oxprenolol Antagonism
Pindolol Antagonism
Propranolol Antagonism
Quinupristin This combination presents an increased risk of toxicity
Telithromycin Telithromycin may reduce clearance of Salmeterol. Concomitant therapy is contraindicated.
Timolol Antagonism
Voriconazole Voriconazole, a strong CYP3A4 inhibitor may increase the serum concentration of salmeterol by decreasing its metabolism. Consider alternate therapy.
Food Interactions Not Available

Targets


Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action yes
Actions agonist
References
  • Rong Y, Arbabian M, Thiriot DS, Seibold A, Clark RB, Ruoho AE: Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol. Biochemistry. 1999 Aug 31;38(35):11278-86. - Pubmed
  • Finney PA, Donnelly LE, Belvisi MG, Chuang TT, Birrell M, Harris A, Mak JC, Scorer C, Barnes PJ, Adcock IM, Giembycz MA: Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha). Br J Pharmacol. 2001 Mar;132(6):1261-70. - Pubmed
  • Green SA, Rathz DA, Schuster AJ, Liggett SB: The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). Eur J Pharmacol. 2001 Jun 15;421(3):141-7. - Pubmed
  • Meliton AY, Munoz NM, Liu J, Lambertino AT, Boetticher E, Myo S, Myou S, Zhu X, Johnson M, Leff AR: Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. J Allergy Clin Immunol. 2003 Aug;112(2):404-10. - Pubmed
  • Brogden RN, Faulds D: Salmeterol xinafoate: a review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease. Allergol Immunopathol (Madr). 1992 Mar-Apr;20(2):72-84. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4721

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5058
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.3355
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.2701
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.24

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2388
193 Beta-1 adrenergic receptor ADRB1 0.2263
4757 Cytochrome P450 2C9 CYP2C9 0.2026
1588 Multidrug resistance protein 1 ABCB1 0.2006
6016 Cytochrome P450 2C19 CYP2C19 0.1751
4200 Cytochrome P450 1A2 CYP1A2 0.1436
6030 Cytochrome P450 2B6 CYP2B6 0.0983
6013 Cytochrome P450 2E1 CYP2E1 0.0769
6024 Cytochrome P450 1A1 CYP1A1 0.07
1517 Beta-3 adrenergic receptor ADRB3 0.0676
5718 Cytochrome P450 2A6 CYP2A6 0.0592
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0539
587 Serum albumin ALB 0.0529
556 Alpha-1A adrenergic receptor ADRA1A 0.0478
320 5-hydroxytryptamine 1A receptor HTR1A 0.0465
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0454
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0451
20 Prostaglandin G/H synthase 1 PTGS1 0.0439
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0433
6106 Cytochrome P450 2C18 CYP2C18 0.0404
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0378
862 Multidrug resistance-associated protein 1 ABCC1 0.0372
6144 Solute carrier family 22 member 2 SLC22A2 0.0372
6145 Solute carrier family 22 member 1 SLC22A1 0.0356
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0354
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0352
318 Alpha-2A adrenergic receptor ADRA2A 0.0347
847 Mu-type opioid receptor OPRM1 0.0343
3923 Cholinesterase BCHE 0.0342
6031 Cytochrome P450 3A43 CYP3A43 0.0316
871 Glucocorticoid receptor NR3C1 0.0316
492 Histamine H1 receptor HRH1 0.0316
824 Sodium-dependent serotonin transporter SLC6A4 0.0301
3811 Cytochrome P450 19A1 CYP19A1 0.0285
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0278
1898 Cytochrome P450 1B1 CYP1B1 0.027
776 Bile salt export pump ABCB11 0.0264
1729 Solute carrier family 22 member 6 SLC22A6 0.0255
467 Delta-type opioid receptor OPRD1 0.0247
885 5-hydroxytryptamine 1B receptor HTR1B 0.0245
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.024
502 5-hydroxytryptamine 2A receptor HTR2A 0.024
632 Alpha-1B adrenergic receptor ADRA1B 0.0234
831 D(2) dopamine receptor DRD2 0.023
696 Kappa-type opioid receptor OPRK1 0.022
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0207
629 Alpha-2B adrenergic receptor ADRA2B 0.0206
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0202
378 Alpha-2C adrenergic receptor ADRA2C 0.0198
290 Prostaglandin G/H synthase 2 PTGS2 0.0197
6143 Solute carrier family 22 member 7 SLC22A7 0.0194
2300 Lysozyme E 0.0191
3633 Lysozyme R 0.0191
5597 Lysozyme 17 0.0191
731 HIV-1 protease HIV-1 protease 0.0191
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0191
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0187
136 Estrogen receptor ESR1 0.0187
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0185
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0184
6182 Cytochrome P450 2J2 CYP2J2 0.0184
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0183
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0182
614 Progesterone receptor PGR 0.0181
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.018
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0178
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0177
6147 Solute carrier family 22 member 3 SLC22A3 0.0177
2164 Multidrug resistance-associated protein 4 ABCC4 0.0175
260 Cytochrome P450 51 ERG11 0.0174
761 Cytochrome P450 51 ERG11 0.0174
3163 Cytochrome P450 51 cyp51 0.0174
118 Organic cation/carnitine transporter 2 SLC22A5 0.0173
713 Sodium-dependent dopamine transporter SLC6A3 0.0172
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0171
638 D(3) dopamine receptor DRD3 0.0169
737 Mineralocorticoid receptor NR3C2 0.0166
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0163
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0157
6142 Solute carrier family 22 member 8 SLC22A8 0.0157
341 5-hydroxytryptamine 3 receptor HTR3A 0.0152
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0151
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.015
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.015
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0149
590 5-hydroxytryptamine 2C receptor HTR2C 0.0149
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0148
6148 Multidrug resistance-associated protein 7 ABCC10 0.0146
4148 Serine/threonine-protein kinase mTOR MTOR 0.0145
232 Corticosteroid-binding globulin SERPINA6 0.0143
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0142
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0142
23 D(1A) dopamine receptor DRD1 0.0142
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0141
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0141
811 Translocator protein TSPO 0.014
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0134
789 Alpha-1D adrenergic receptor ADRA1D 0.0133
468 Cytochrome P450 4A11 CYP4A11 0.0132
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.013
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0129
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0129
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
465 Calmodulin CALM1 0.0123
3941 Amine oxidase [flavin-containing] A MAOA 0.0123
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.012
777 Tumor necrosis factor TNF 0.0119
756 Sex hormone-binding globulin SHBG 0.0116
817 DNA topoisomerase 2-alpha TOP2A 0.0116
29 Tubulin beta-1 chain TUBB1 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
3810 Catechol O-methyltransferase COMT 0.0114
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0114
504 Mast/stem cell growth factor receptor KIT 0.0111
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0111
844 Epidermal growth factor receptor EGFR 0.011
833 Organic cation/carnitine transporter 1 SLC22A4 0.011
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0109
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0109
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0108
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0105
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0105
146 Androgen receptor AR 0.01
432 D(4) dopamine receptor DRD4 0.0099
818 50S ribosomal protein L10 rplJ 0.0095
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0094
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0092
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0091
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0091
725 5-hydroxytryptamine 1D receptor HTR1D 0.0091
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.009
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.009
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.009
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.009
380 Cytochrome P450 17A1 CYP17A1 0.009
407 Vascular endothelial growth factor receptor 2 KDR 0.009
6020 Aldehyde oxidase AOX1 0.0089
26 Vascular endothelial growth factor receptor 3 FLT4 0.0089
952 Dipeptidyl peptidase 4 DPP4 0.0088
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0088
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0087
6141 Sodium/bile acid cotransporter SLC10A1 0.0087
228 Beta platelet-derived growth factor receptor PDGFRB 0.0087
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0087
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0087
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0086
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0086
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0086
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0086
1024 Solute carrier family 22 member 11 SLC22A11 0.0086
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0085
716 5-hydroxytryptamine 7 receptor HTR7 0.0085
32 Vascular endothelial growth factor receptor 1 FLT1 0.0085
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0084
768 FK506-binding protein 1A FKBP1A 0.0083
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0083
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0082
4604 Liver carboxylesterase 1 CES1 0.0082
1820 Beta-nerve growth factor NGF 0.0081
208 DNA-directed RNA polymerase beta' chain rpoC 0.0081
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0081
1010 Cytochrome P450 51A1 CYP51A1 0.008
6136 Multidrug resistance-associated protein 5 ABCC5 0.008
427 Substance-P receptor TACR1 0.0079
1256 5-hydroxytryptamine 6 receptor HTR6 0.0078
94 5-hydroxytryptamine 4 receptor HTR4 0.0078
723 Cytosolic phospholipase A2 PLA2G4A 0.0077
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0077
6102 Arylamine N-acetyltransferase 2 NAT2 0.0076
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0076
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0075
828 Phenylalanine-4-hydroxylase PAH 0.0075
3109 Phenylalanine-4-hydroxylase phhA 0.0075
477 DNA topoisomerase 4 subunit A parC 0.0074
886 DNA topoisomerase 4 subunit A parC 0.0074
6226 DNA topoisomerase 4 subunit A parC 0.0074
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0074
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0074
2539 Tubulin alpha-1 chain TUBA4A 0.0073
404 DNA gyrase subunit A gyrA 0.0073
6224 DNA gyrase subunit A gyrA 0.0073
122 P2Y purinoceptor 12 P2RY12 0.0072
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0071
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0071
4120 NADPH--cytochrome P450 reductase POR 0.0071
6220 Aryl hydrocarbon receptor AHR 0.0071
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.007
6137 Multidrug resistance-associated protein 6 ABCC6 0.0069
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0068
4237 50S ribosomal protein L22 rplV 0.0068
3939 Amine oxidase [flavin-containing] B MAOB 0.0068
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0068
70 Type-1 angiotensin II receptor AGTR1 0.0067
705 Glutamate receptor 1 GRIA1 0.0067
161 Tubulin beta chain TUBB 0.0066
312 Tubulin beta chain TUB2 0.0066
869 Estrogen receptor beta ESR2 0.0066
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0066
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0065
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0065
165 FL cytokine receptor FLT3 0.0065
814 Ryanodine receptor 1 RYR1 0.0064
469 Annexin A1 ANXA1 0.0064
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0063
1050 Bile salt sulfotransferase SULT2A1 0.0063
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
2183 Fatty acid-binding protein, adipocyte FABP4 0.0061
1852 Microtubule-associated protein 2 MAP2 0.0061
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.006
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0059
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0059
5300 Antigen peptide transporter 1 TAP1 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
1483 Membrane copper amine oxidase AOC3 0.0059
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0058
124 Histamine H2 receptor HRH2 0.0058
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0058
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0057
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0057
1196 Complement decay-accelerating factor CD55 0.0056
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0056
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0055
5923 Microtubule-associated protein tau MAPT 0.0055
5924 Microtubule-associated protein 4 MAP4 0.0055
273 Apoptosis regulator Bcl-2 BCL2 0.0054
4238 50S ribosomal protein L4 rplD 0.0054
5578 50S ribosomal protein L4 rplD 0.0054
6173 50S ribosomal protein L4 rplD 0.0054
6219 50S ribosomal protein L4 rplD 0.0054
3086 Plasmepsin-2 Not Available 0.0053
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0053
1656 CYP2B protein CYP2B 0.0053
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0053
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0052
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0052
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0051
88 Retinoic acid receptor RXR-beta RXRB 0.0051
131 Synaptic vesicular amine transporter SLC18A2 0.0051
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0051
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0051
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
84 Nuclear receptor 0B1 NR0B1 0.005
606 Cytochrome P450 27, mitochondrial CYP27A1 0.005
436 5-hydroxytryptamine 2B receptor HTR2B 0.005
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0049
1541 Metalloproteinase mmp20 0.0049
2808 Chloramphenicol acetyltransferase 3 cat3 0.0049
239 Coagulation factor X F10 0.0048
738 Monocarboxylate transporter 1 SLC16A1 0.0047
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0047
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0046
3947 Xanthine dehydrogenase/oxidase XDH 0.0046
284 DNA-directed RNA polymerase beta chain rpoB 0.0046
5773 DNA-directed RNA polymerase beta chain rpoB 0.0046
4203 Histamine N-methyltransferase HNMT 0.0046
3932 Glutathione S-transferase A2 GSTA2 0.0046
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0045
365 Dihydrofolate reductase DHFR 0.0045
2381 Dihydrofolate reductase DFR1 0.0045
2833 Dihydrofolate reductase Not Available 0.0045
2931 Dihydrofolate reductase folA 0.0045
3544 Dihydrofolate reductase folA 0.0045
3682 Dihydrofolate reductase folA 0.0045
6642 Dihydrofolate reductase folA 0.0045
6756 Dihydrofolate reductase dfrA 0.0045
3601 Dihydropteroate synthase 1 folP1 0.0045
3807 Dihydropteroate synthase 1 folP1 0.0045
3808 Dihydropteroate synthase 2 folP2 0.0045
2417 Chloramphenicol acetyltransferase cat 0.0045
3278 Chloramphenicol acetyltransferase cat 0.0045
163 D(1B) dopamine receptor DRD5 0.0044
16 Adenosine A1 receptor ADORA1 0.0044
2810 Dr hemagglutinin structural subunit draA 0.0044
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0044
528 5-hydroxytryptamine 1E receptor HTR1E 0.0044
4122 Histone deacetylase 2 HDAC2 0.0044
1176 Mitogen-activated protein kinase 1 MAPK1 0.0043
6085 Fatty acid-binding protein, intestinal FABP2 0.0043
1178 Adenosine A2a receptor ADORA2A 0.0043
856 Vitamin D3 receptor VDR 0.0043
275 Arachidonate 5-lipoxygenase ALOX5 0.0043
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0043
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0043
891 Dihydropteroate synthase folP 0.0043
5359 Dihydropteroate synthase folP 0.0043
7175 Dihydropteroate synthase sulI 0.0043
6014 Cytochrome P450 2A13 CYP2A13 0.0043
295 Carbonic anhydrase 1 CA1 0.0043
3913 Glutamic acid decarboxylase GAD65 0.0042
2112 Toll-like receptor 9 TLR9 0.0042
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0042
162 Retinoic acid receptor gamma-1 RARG 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0041
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0041
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.004
319 Opioid receptor, sigma 1 OPRS1 0.004
373 Transthyretin TTR 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4311 tRNA TRDMT1 0.0039
4325 tRNA trmD 0.0039
4328 tRNA trmD 0.0039
1630 Integrin beta-2 ITGB2 0.0038
976 Platelet glycoprotein IX GP9 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
1757 Myeloperoxidase MPO 0.0037
6174 50S ribosomal protein L32 rpmF 0.0037
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0037
823 Fibroblast growth factor receptor 2 FGFR2 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
54 Prothrombin F2 0.0036
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0035
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0035
1618 High affinity nerve growth factor receptor NTRK1 0.0035
4773 Deoxycytidine kinase DCK 0.0035
3904 Alanine aminotransferase 2 GPT2 0.0035
735 Alanine aminotransferase 1 GPT 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0035
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3856 Fibroblast growth factor receptor 3 FGFR3 0.0034
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0034
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0034
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0034
1374 Natriuretic peptides B NPPB 0.0033
1827 Gap junction alpha-1 protein GJA1 0.0033
1908 Vascular cell adhesion protein 1 VCAM1 0.0033
474 Acetylcholinesterase ACHE 0.0033
174 Sigma 1-type opioid receptor SIGMAR1 0.0033
3809 Estrogen-related receptor gamma ESRRG 0.0033
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
5880 Thrombopoietin receptor MPL 0.0033
921 Glutamate receptor 2 GRIA2 0.0033
6048 Troponin C, skeletal muscle TNNC2 0.0032
719 Retinoic acid receptor responder protein 1 RARRES1 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
770 Retinoic acid-induced protein 3 GPRC5A 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
153 Dopamine beta-hydroxylase DBH 0.0031
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0031
1192 Sulfotransferase 1A1 SULT1A1 0.0031
6044 Serum paraoxonase/lactonase 3 PON3 0.0031
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0031
1648 Elastin ELN 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
183 Vascular endothelial growth factor A VEGFA 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
5787 Angiopoietin-1 receptor TEK 0.003
1629 Transcription factor AP-1 JUN 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.003
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0029
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0029
6138 Multidrug resistance protein 3 ABCB4 0.0029
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0029
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0029
24 Thymidylate synthase TMP1 0.0028
359 Thymidylate synthase TYMS 0.0028
2626 Thymidylate synthase thyA 0.0028
2729 Thymidylate synthase thyA 0.0028
5352 Thymidylate synthase THYA 0.0028
572 Integrin alpha-L ITGAL 0.0028
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0028
569 Retinal dehydrogenase 2 ALDH1A2 0.0028
267 Plasminogen activator inhibitor 1 SERPINE1 0.0028
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0028
4192 DNA topoisomerase 2-beta TOP2B 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6432 Transporter snf 0.0027
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0026
611 Retinal dehydrogenase 1 ALDH1A1 0.0026
581 Cytochrome P450 2R1 CYP2R1 0.0026
49 Endothelin B receptor EDNRB 0.0026
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0025
5934 Cytochrome P450 26A1 CYP26A1 0.0025
6221 Steroid hormone receptor ERR1 ESRRA 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
578 Endothelin-1 receptor EDNRA 0.0024
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0024
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0024
6824 Tyrosine-protein kinase Lyn LYN 0.0024
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0024
6151 Monocarboxylate transporter 10 SLC16A10 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
229 Retinoic acid receptor beta RARB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
518 Peroxidase/catalase T katG 0.0023
2216 Fibroblast growth factor receptor 4 FGFR4 0.0023
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
33 Cystine/glutamate transporter SLC7A11 0.0023
904 Glutathione S-transferase P GSTP1 0.0022
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0022
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
1864 RET proto-oncogene RET 0.002
594 Thyroxine-binding globulin SERPINA7 0.002
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.002
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.002
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.002
1360 Sphingomyelin phosphodiesterase SMPD1 0.002
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
936 Ephrin type-A receptor 2 EPHA2 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0019
4210 Toll-like receptor 4 TLR4 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
1262 Corticotropin-lipotropin POMC 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
683 Potassium transporter GK0582 0.0018
751 Potassium channel subfamily K member 6 KCNK6 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0017
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0017
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
7 Nitric oxide synthase, inducible NOS2 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
1039 Histone deacetylase 9 HDAC9 0.0016
908 Glutathione S-transferase theta-1 GSTT1 0.0016
3233 Bile acid receptor NR1H4 0.0015
1992 Vitamin D-binding protein GC 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
4103 Proteasome subunit beta type 2 PSMB2 0.0014
4102 Proteasome subunit beta type 5 PSMB5 0.0014
4101 Proteasome subunit beta type 1 PSMB1 0.0014
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0014
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
4217 Telomerase reverse transcriptase TERT 0.0013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0013
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3937 Fatty-acid amide hydrolase FAAH 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0012
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0012
489 Monocarboxylate transporter 2 SLC16A7 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
164 Histamine H4 receptor HRH4 0.001
5798 Mitogen-activated protein kinase 11 MAPK11 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2320 Thymidine kinase, cytosolic TK1 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
6149 Solute carrier family 22 member 10 SLC22A10 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
760 Fibroblast growth factor 1 FGF1 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
4226 Uridine phosphorylase 2 UPP2 0.0009
2207 Rhodopsin RHO 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6218 Pannexin-1 PANX1 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6677 Myelin P2 protein PMP2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
4225 Uridine phosphorylase 1 UPP1 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0008
413 Amidophosphoribosyltransferase PPAT 0.0008
2515 Amidophosphoribosyltransferase purF 0.0008
3714 Amidophosphoribosyltransferase purF 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
2021 Thrombomodulin THBD 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2298 Cytochrome P450-cam camC 0.0008
3957 Adenosine deaminase ADA 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
3639 Thymidine phosphorylase deoA 0.0007
3936 Thymidine phosphorylase TYMP 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
3917 Methylenetetrahydrofolate reductase MTHFR 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
563 Thyroid peroxidase TPO 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
517 Alcohol dehydrogenase 1C ADH1C 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
4920 Peroxidase/catalase katG 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
3221 Cytochrome c4 cc4 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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