DT-Web

DB01580 - Oxprenolol


Identification
Name Oxprenolol
Accession Number DB01580
Type small molecule
Description A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 265.348
Groups approved
Monoisotopic Weight 265.167793607
Pharmacology
Indication Used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.
Mechanism of action Like other beta-adrenergic antagonists, oxprenolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, oxprenolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing heart rate, cardiac output, and systolic and diastolic blood pressure. It also blocks beta-2 adrenergic receptors located in bronchiole smooth muscle, causing vasoconstriction. By binding beta-2 receptors in the juxtaglomerular apparatus, oxprenolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production. Oxprenolol therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.
Absorption Oral bioavailability is 20-70%.
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetohexamide The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Chlorpropamide The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Clonidine Increased hypertension when clonidine stopped
Dihydroergotamine Ischemia with risk of gangrene
Dihydroergotoxine Ischemia with risk of gangrene
Disopyramide The beta-blocker, oxprenolol, may increase the toxicity of disopyramide.
Epinephrine Hypertension, then bradycardia
Ergonovine Ischemia with risk of gangrene
Ergotamine Ischemia with risk of gangrene
Fenoterol Antagonism
Formoterol Antagonism
Gliclazide The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Glipizide The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Glisoxepide The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Glyburide The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Glycodiazine The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Ibuprofen Risk of inhibition of renal prostaglandins
Indomethacin Risk of inhibition of renal prostaglandins
Insulin Glargine The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Isoproterenol Antagonism
Lidocaine The beta-blocker increases the effect and toxicity of lidocaine
Methyldopa Possible hypertensive crisis
Methysergide Ischemia with risk of gangrene
Orciprenaline Antagonism
Pipobroman Antagonism
Pirbuterol Antagonism
Piroxicam Risk of inhibition of renal prostaglandins
Practolol Antagonism
Prazosin Risk of hypotension at the beginning of therapy
Repaglinide The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Salbutamol Antagonism
Salmeterol Antagonism
Terazosin Increased risk of hypotension. Initiate concomitant therapy cautiously.
Terbutaline Antagonism
Tolazamide The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Tolbutamide The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Verapamil Increased effect of both drugs
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.
  • Avoid natural licorice.

Targets


Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Campbell CA, Parratt JR, Kane KA, Bullock G: Effects of prolonged administration of oxprenolol on severity of ischaemic arrhythmias, enzyme leakage, infarct size, and intracellular cardiac muscle action potentials. J Cardiovasc Pharmacol. 1984 May-Jun;6(3):369-77. - Pubmed
  • Lemmer B: [Pharmacological basis for the therapy of cardiovascular disease with beta-adrenoceptor blocking drugs (author's transl)] Herz. 1982 Jun;7(3):168-78. - Pubmed
  • Abrahamsson T: The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat. Br J Pharmacol. 1986 Apr;87(4):657-64. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7159
Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action unknown
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sekut L, Champion BR, Page K, Menius JA Jr, Connolly KM: Anti-inflammatory activity of salmeterol: down-regulation of cytokine production. Clin Exp Immunol. 1995 Mar;99(3):461-6. - Pubmed
  • Fujita H, Tanaka J, Maeda N, Sakanaka M: Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor. Neurosci Lett. 1998 Feb 6;242(1):37-40. - Pubmed
  • Prinz M, Hausler KG, Kettenmann H, Hanisch U: beta-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia. Brain Res. 2001 Apr 27;899(1-2):264-70. - Pubmed
DTHybrid score 0.7251

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3451

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Dudley AJ, Bleasby K, Brown CD: The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9. - Pubmed
DTHybrid score 0.1793

Predictions


Id Partner name Gene Name Score
1517 Beta-3 adrenergic receptor ADRB3 0.14
4512 Cytochrome P450 3A4 CYP3A4 0.1364
1588 Multidrug resistance protein 1 ABCB1 0.1094
6145 Solute carrier family 22 member 1 SLC22A1 0.0984
4200 Cytochrome P450 1A2 CYP1A2 0.0897
6016 Cytochrome P450 2C19 CYP2C19 0.0851
556 Alpha-1A adrenergic receptor ADRA1A 0.0815
4757 Cytochrome P450 2C9 CYP2C9 0.0702
320 5-hydroxytryptamine 1A receptor HTR1A 0.0654
318 Alpha-2A adrenergic receptor ADRA2A 0.051
4118 Cytochrome P450 3A5 CYP3A5 0.049
6024 Cytochrome P450 1A1 CYP1A1 0.0448
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0446
118 Organic cation/carnitine transporter 2 SLC22A5 0.0437
6147 Solute carrier family 22 member 3 SLC22A3 0.0435
4924 Cytochrome P450 2C8 CYP2C8 0.0423
6107 Cytochrome P450 3A7 CYP3A7 0.0409
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0399
824 Sodium-dependent serotonin transporter SLC6A4 0.0396
3923 Cholinesterase BCHE 0.0392
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0382
885 5-hydroxytryptamine 1B receptor HTR1B 0.0371
492 Histamine H1 receptor HRH1 0.036
632 Alpha-1B adrenergic receptor ADRA1B 0.0357
6030 Cytochrome P450 2B6 CYP2B6 0.0345
629 Alpha-2B adrenergic receptor ADRA2B 0.0342
6013 Cytochrome P450 2E1 CYP2E1 0.0321
5718 Cytochrome P450 2A6 CYP2A6 0.0319
378 Alpha-2C adrenergic receptor ADRA2C 0.0314
713 Sodium-dependent dopamine transporter SLC6A3 0.0295
2300 Lysozyme E 0.0273
3633 Lysozyme R 0.0273
5597 Lysozyme 17 0.0273
833 Organic cation/carnitine transporter 1 SLC22A4 0.0272
831 D(2) dopamine receptor DRD2 0.0254
3941 Amine oxidase [flavin-containing] A MAOA 0.0239
502 5-hydroxytryptamine 2A receptor HTR2A 0.0235
789 Alpha-1D adrenergic receptor ADRA1D 0.0231
3810 Catechol O-methyltransferase COMT 0.0227
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0218
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0205
23 D(1A) dopamine receptor DRD1 0.0189
828 Phenylalanine-4-hydroxylase PAH 0.0185
3109 Phenylalanine-4-hydroxylase phhA 0.0185
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0181
6142 Solute carrier family 22 member 8 SLC22A8 0.0178
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0175
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0168
1820 Beta-nerve growth factor NGF 0.0166
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0165
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.016
124 Histamine H2 receptor HRH2 0.0155
341 5-hydroxytryptamine 3 receptor HTR3A 0.0152
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0151
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0151
131 Synaptic vesicular amine transporter SLC18A2 0.015
1729 Solute carrier family 22 member 6 SLC22A6 0.0147
862 Multidrug resistance-associated protein 1 ABCC1 0.0146
590 5-hydroxytryptamine 2C receptor HTR2C 0.0145
3939 Amine oxidase [flavin-containing] B MAOB 0.014
638 D(3) dopamine receptor DRD3 0.0128
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0125
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
587 Serum albumin ALB 0.0123
6106 Cytochrome P450 2C18 CYP2C18 0.0123
3076 Antigen 85-C fbpC 0.0122
777 Tumor necrosis factor TNF 0.0121
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.012
20 Prostaglandin G/H synthase 1 PTGS1 0.012
776 Bile salt export pump ABCB11 0.0118
465 Calmodulin CALM1 0.0117
7 Nitric oxide synthase, inducible NOS2 0.0116
847 Mu-type opioid receptor OPRM1 0.0113
432 D(4) dopamine receptor DRD4 0.0112
6164 POU domain, class 5, transcription factor 1 POU5F1 0.011
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0108
474 Acetylcholinesterase ACHE 0.0102
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0102
274 Muscarinic acetylcholine receptor M5 CHRM5 0.01
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0098
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0097
1898 Cytochrome P450 1B1 CYP1B1 0.0095
436 5-hydroxytryptamine 2B receptor HTR2B 0.0095
6847 Lactase-phlorizin hydrolase LCT 0.0093
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0092
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0088
6143 Solute carrier family 22 member 7 SLC22A7 0.0087
467 Delta-type opioid receptor OPRD1 0.0087
1024 Solute carrier family 22 member 11 SLC22A11 0.0087
6010 Thiamine transporter 1 SLC19A2 0.0086
696 Kappa-type opioid receptor OPRK1 0.0083
1176 Mitogen-activated protein kinase 1 MAPK1 0.0083
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0081
4203 Histamine N-methyltransferase HNMT 0.0081
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0079
175 Thiamin pyrophosphokinase 1 TPK1 0.0077
163 D(1B) dopamine receptor DRD5 0.0076
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
4773 Deoxycytidine kinase DCK 0.0074
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0074
817 DNA topoisomerase 2-alpha TOP2A 0.0073
3947 Xanthine dehydrogenase/oxidase XDH 0.0071
1374 Natriuretic peptides B NPPB 0.0068
1827 Gap junction alpha-1 protein GJA1 0.0067
1908 Vascular cell adhesion protein 1 VCAM1 0.0067
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0066
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0065
6137 Multidrug resistance-associated protein 6 ABCC6 0.0065
6148 Multidrug resistance-associated protein 7 ABCC10 0.0063
6432 Transporter snf 0.0062
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0061
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0061
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0061
2164 Multidrug resistance-associated protein 4 ABCC4 0.006
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0058
1256 5-hydroxytryptamine 6 receptor HTR6 0.0057
716 5-hydroxytryptamine 7 receptor HTR7 0.0057
477 DNA topoisomerase 4 subunit A parC 0.0056
886 DNA topoisomerase 4 subunit A parC 0.0056
6226 DNA topoisomerase 4 subunit A parC 0.0056
725 5-hydroxytryptamine 1D receptor HTR1D 0.0056
1360 Sphingomyelin phosphodiesterase SMPD1 0.0056
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0056
404 DNA gyrase subunit A gyrA 0.0055
6224 DNA gyrase subunit A gyrA 0.0055
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0055
1770 Phospholipase C PLCL1 0.0055
2841 Phospholipase C plc 0.0055
731 HIV-1 protease HIV-1 protease 0.0052
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0052
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0052
6136 Multidrug resistance-associated protein 5 ABCC5 0.0051
183 Vascular endothelial growth factor A VEGFA 0.005
198 Sodium channel protein type 10 subunit alpha SCN10A 0.005
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0048
6070 Nischarin NISCH 0.0048
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0047
380 Cytochrome P450 17A1 CYP17A1 0.0047
694 Matrix protein 2 M 0.0047
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0046
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0046
161 Tubulin beta chain TUBB 0.0045
312 Tubulin beta chain TUB2 0.0045
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0045
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0045
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0045
6151 Monocarboxylate transporter 10 SLC16A10 0.0045
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0044
2112 Toll-like receptor 9 TLR9 0.0044
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0044
2472 Voltage-gated potassium channel kcsA 0.0043
6366 Voltage-gated potassium channel kcsA 0.0043
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0043
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0043
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0043
1830 5'-nucleotidase NT5E 0.0042
164 Histamine H4 receptor HRH4 0.0042
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0041
1341 Histamine H3 receptor HRH3 0.0041
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0041
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0041
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.004
1629 Transcription factor AP-1 JUN 0.004
125 DNA polymerase beta POLB 0.004
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.004
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0039
6212 Tubulin gamma-1 chain TUBG1 0.0039
6210 Tubulin delta chain TUBD1 0.0039
6211 Tubulin epsilon chain TUBE1 0.0039
738 Monocarboxylate transporter 1 SLC16A1 0.0038
6146 High affinity copper uptake protein 1 SLC31A1 0.0037
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0037
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0037
527 Prostacyclin receptor PTGIR 0.0036
723 Cytosolic phospholipase A2 PLA2G4A 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0036
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0036
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0036
672 Prostaglandin F2-alpha receptor PTGFR 0.0035
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0035
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0035
5126 Arginase rocF 0.0035
3611 Cytidine deaminase cdd 0.0035
3707 Cytidine deaminase cdd 0.0035
4211 Cytidine deaminase CDA 0.0035
504 Mast/stem cell growth factor receptor KIT 0.0034
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0034
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0034
3811 Cytochrome P450 19A1 CYP19A1 0.0034
6506 Stathmin-4 STMN4 0.0033
94 5-hydroxytryptamine 4 receptor HTR4 0.0033
6163 Copper-transporting ATPase 2 ATP7B 0.0033
6165 Copper-transporting ATPase 1 ATP7A 0.0033
6182 Cytochrome P450 2J2 CYP2J2 0.0033
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0033
173 Toll-like receptor 7 TLR7 0.0033
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0032
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0031
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0031
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0031
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0031
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0031
6111 DNA polymerase epsilon subunit 4 POLE4 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6112 DNA polymerase epsilon subunit 3 POLE3 0.0031
976 Platelet glycoprotein IX GP9 0.0031
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0031
6110 DNA polymerase epsilon subunit 2 POLE2 0.0031
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
740 Argininosuccinate synthase ASS1 0.0031
865 Argininosuccinate synthase ASS1 0.0031
2680 Argininosuccinate synthase argG 0.0031
3194 Argininosuccinate synthase argG 0.0031
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
4152 Superoxide dismutase [Cu-Zn] SOD1 0.003
908 Glutathione S-transferase theta-1 GSTT1 0.003
4120 NADPH--cytochrome P450 reductase POR 0.003
1757 Myeloperoxidase MPO 0.003
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0028
904 Glutathione S-transferase P GSTP1 0.0028
6031 Cytochrome P450 3A43 CYP3A43 0.0028
468 Cytochrome P450 4A11 CYP4A11 0.0028
233 Potassium channel subfamily K member 2 KCNK2 0.0028
2449 Tubulin alpha-3 chain TUBA1A 0.0028
290 Prostaglandin G/H synthase 2 PTGS2 0.0027
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0027
624 Guanidinoacetate N-methyltransferase GAMT 0.0027
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0027
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0027
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0027
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0027
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0027
6141 Sodium/bile acid cotransporter SLC10A1 0.0027
896 Glutathione S-transferase Mu 1 GSTM1 0.0026
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0026
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0025
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0025
228 Beta platelet-derived growth factor receptor PDGFRB 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0024
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
4217 Telomerase reverse transcriptase TERT 0.0024
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0024
342 P protein [Includes: DNA-directed DNA polymerase P 0.0024
612 P protein [Includes: DNA-directed DNA polymerase P 0.0024
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0024
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0024
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0024
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0024
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0024
603 DNA polymerase alpha catalytic subunit POLA1 0.0024
1864 RET proto-oncogene RET 0.0023
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0023
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0023
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0023
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0023
6014 Cytochrome P450 2A13 CYP2A13 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0022
153 Dopamine beta-hydroxylase DBH 0.0021
614 Progesterone receptor PGR 0.0021
1618 High affinity nerve growth factor receptor NTRK1 0.0021
6171 Solute carrier family 28 member 3 SLC28A3 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
5626 Nucleoside diphosphate kinase B NME2 0.0021
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.002
158 Sodium channel protein type 1 subunit alpha SCN1A 0.002
702 UMP-CMP kinase CMPK1 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.002
174 Sigma 1-type opioid receptor SIGMAR1 0.002
136 Estrogen receptor ESR1 0.002
1656 CYP2B protein CYP2B 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0019
3926 Choline transporter-like protein 2 SLC44A2 0.0019
3925 Choline transporter-like protein 4 SLC44A4 0.0019
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0019
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0019
3927 Choline transporter-like protein 3 SLC44A3 0.0019
1686 Choline transporter-like protein 1 SLC44A1 0.0019
861 Choline kinase alpha CHKA 0.0019
769 High-affinity choline transporter 1 SLC5A7 0.0019
700 Choline dehydrogenase, mitochondrial CHDH 0.0019
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0019
576 Choline O-acetyltransferase CHAT 0.0019
3922 Phospholipase D2 PLD2 0.0019
3924 Phospholipase D1 PLD1 0.0019
5682 Ribonuclease pancreatic RNASE1 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
871 Glucocorticoid receptor NR3C1 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
737 Mineralocorticoid receptor NR3C2 0.0019
4192 DNA topoisomerase 2-beta TOP2B 0.0019
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0018
2320 Thymidine kinase, cytosolic TK1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
844 Epidermal growth factor receptor EGFR 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
528 5-hydroxytryptamine 1E receptor HTR1E 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
277 Purine nucleoside phosphorylase PNP 0.0018
2870 Purine nucleoside phosphorylase punA 0.0018
2945 Purine nucleoside phosphorylase punA 0.0018
4659 Purine nucleoside phosphorylase TM_1596 0.0018
4825 Purine nucleoside phosphorylase TTHA1435 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0017
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0016
146 Androgen receptor AR 0.0016
5294 Nucleoside diphosphate kinase A NME1 0.0016
6218 Pannexin-1 PANX1 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6220 Aryl hydrocarbon receptor AHR 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0016
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0015
4604 Liver carboxylesterase 1 CES1 0.0015
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0015
1050 Bile salt sulfotransferase SULT2A1 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
3086 Plasmepsin-2 Not Available 0.0014
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0014
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0014
373 Transthyretin TTR 0.0014
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
3404 Exotoxin A eta 0.0013
6149 Solute carrier family 22 member 10 SLC22A10 0.0013
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0013
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0013
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0013
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0013
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0013
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0013
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0013
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0013
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0012
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0011
473 L-lactate dehydrogenase A chain LDHA 0.0011
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0011
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0011
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0011
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
6085 Fatty acid-binding protein, intestinal FABP2 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.001
869 Estrogen receptor beta ESR2 0.001
260 Cytochrome P450 51 ERG11 0.001
761 Cytochrome P450 51 ERG11 0.001
3163 Cytochrome P450 51 cyp51 0.001
144 Hemoglobin subunit alpha HBA1 0.001
518 Peroxidase/catalase T katG 0.001
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
563 Thyroid peroxidase TPO 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
295 Carbonic anhydrase 1 CA1 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
756 Sex hormone-binding globulin SHBG 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
482 Glycine receptor subunit alpha-1 GLRA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
592 Carbonic anhydrase 4 CA4 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0004
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
3957 Adenosine deaminase ADA 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
469 Annexin A1 ANXA1 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
2207 Rhodopsin RHO 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
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