DT-Web: DB00457

Identification

Name

Prazosin

Accession Number

DB00457 (APRD00020)

Type

small molecule

Description

Prazosin is a selective α-₁-adrenergic receptor antagonist used to treat hypertension. It has also been used to decrease urinary obstruction and relieve symptoms associated with symptomatic benign prostatic hyperplasia. α₁-Receptors mediate contraction and hypertrophic growth of smooth muscle cells. Antagonism of these receptors leads to smooth muscle relaxation in the peripheral vasculature and prostate gland. Prazosin has also been used in conjunction with cardiac glycosides and diuretics in the management of severe congestive heart failure. It has also been used alone or in combination with β-blockers in the preoperative management of signs and symptoms of pheochromocytoma.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

383.4011

Groups

approved

Monoisotopic Weight

383.159354185

Pharmacology

Indication

For treatment of hypertension, symptomatic benign prostatic hyperplasia, and severe congestive heart failure. May also be used alone or in combination with β-blockers in the preoperative management of signs and symptoms of pheochromocytoma.

Mechanism of action

Prazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

Absorption

Well-absorbed from gastrointestinal tract; bioavailability is variable (50 to 85%).

Protein binding

97%

Biotransformation

Primarily hepatic. Several metabolites have been identified in humans and animals (6- O -demethyl, 7- O -demethyl, 2-[1-piperazinyl]-4-amino-6, 7-dimethoxyquinazoline, 2,4-diamino-6,7-dimethoxyquinazoline).

Route of elimination

Animal studies indicate that prazosin hydrochloride is extensively metabolized, primarily by demethylation and conjugation, and excreted mainly via bile and feces. Less extensive human studies suggest similar metabolism and excretion in man.

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acebutolol	Risk of hypotension at the beginning of therapy
Atenolol	Risk of hypotension at the beginning of therapy
Betaxolol	Beta-Blockers such as betaxolol may enhance the orthostatic hypotensive effect of Alpha1-Blockers such as prazosin. The risk associated with ophthalmic products is probably less than systemic products. Exercise caution if an alpha1-blocker is added to existing beta-blocker therapy. Monitor for hypotension during first few days of concomitant therapy. A priori reduction in alpha1-blocker (especially systemic) dose may be warranted. Administering the first dose of systemic agents at bedtime may help minimize risk of severe hypotension. The risk associated with the use of ophthalmic products in either interacting group is probably less than that associated with systemic agents. If the alpha1-blocker is being used to treat BPH, consider using tamsulosin since its alpha1-A selectivity is least likely to cause hypotension.
Bevantolol	Risk of hypotension at the beginning of therapy
Bisoprolol	Risk of hypotension at the beginning of therapy
Carteolol	Risk of hypotension at the beginning of therapy
Carvedilol	Risk of hypotension at the beginning of therapy
Dabigatran etexilate	P-Glycoprotein inducers such as prazosin may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Digoxin	Prazosin increases the effect of digoxin
Esmolol	Risk of hypotension at the beginning of therapy
Labetalol	Risk of hypotension at the beginning of therapy
Metoprolol	Risk of hypotension at the beginning of therapy
Nadolol	Risk of hypotension at the beginning of therapy
Oxprenolol	Risk of hypotension at the beginning of therapy
Penbutolol	Risk of hypotension at the beginning of therapy
Pindolol	Risk of hypotension at the beginning of therapy
Practolol	Risk of hypotension at the beginning of therapy
Propranolol	Risk of hypotension at the beginning of therapy
Sotalol	Risk of hypotension at the beginning of therapy
Tadalafil	Tadalafil may enhance the hypotensive effect of Prazosin. Monitor for hypotension during concomitant therapy.
Tamsulosin	Concomitant use of alpha1-adrenergic antagonists, Tamsulosin and Prazosin, may result in additive antihypertensive effects. Combination therapy is not recommended.
Timolol	Risk of hypotension at the beginning of therapy
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Vardenafil	Additive hypotensive effects of the PDE5 inhibitor, Vardenafil, and alpha1-blocker, Prazosin, may occur. Monitor for hypotension during concomitant therapy.
Verapamil	Risk of hypotension at the beginning of therapy

Food Interactions

Take without regard to meals.
Avoid alcohol.
Avoid natural licorice.

Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	yes
Actions	antagonist
References	Chang HK, Hsu FL, Liu IM, Cheng JT: Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in-vitro. J Pharm Pharmacol. 2003 Jun;55(6):833-7. - Pubmed Eltze M: In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73. - Pubmed Morris DP, Price RR, Smith MP, Lei B, Schwinn DA: Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent. Mol Pharmacol. 2004 Oct;66(4):843-54. Epub 2004 Jul 16. - Pubmed Sleight AJ, Koek W, Bigg DC: Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors. Eur J Pharmacol. 1993 Jul 20;238(2-3):407-10. - Pubmed Suzuki Y, Kanada A, Okaya Y, Aisaka K: Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs. Eur J Pharmacol. 2000 Apr 7;394(1):123-30. - Pubmed Tomiyama Y, Kobayashi K, Tadachi M, Kobayashi S, Inada Y, Kobayashi M, Yamazaki Y: Expressions and mechanical functions of alpha(1)-adrenoceptor subtypes in hamster ureter. Eur J Pharmacol. 2007 Nov 14;573(1-3):201-5. Epub 2007 Jul 6. - Pubmed Zacharia J, Hillier C, MacDonald A: Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries. Br J Pharmacol. 2004 Mar;141(6):915-24. Epub 2004 Feb 23. - Pubmed Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.6314
Alpha-1B adrenergic receptor
Name	Alpha-1B adrenergic receptor
Gene Name	ADRA1B
Pharmacological action	yes
Actions	antagonist
References	Al-Damluji S, Shen WB, White S, Barnard EA: alpha(1B) adrenergic receptors in gonadotrophin-releasing hormone neurones: relation to Transport-P. Br J Pharmacol. 2001 Jan;132(1):336-44. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Eltze M: In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73. - Pubmed Ishiguro M, Futabayashi Y, Ohnuki T, Ahmed M, Muramatsu I, Nagatomo T: Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling. Life Sci. 2002 Oct 11;71(21):2531-41. - Pubmed Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF, Adams DJ, Lewis RJ: Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA. J Biol Chem. 2003 Sep 5;278(36):34451-7. Epub 2003 Jun 24. - Pubmed Sleight AJ, Koek W, Bigg DC: Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors. Eur J Pharmacol. 1993 Jul 20;238(2-3):407-10. - Pubmed Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.5184
Alpha-1D adrenergic receptor
Name	Alpha-1D adrenergic receptor
Gene Name	ADRA1D
Pharmacological action	yes
Actions	antagonist
References	Nagaoka Y, Ahmed M, Hossain M, Bhuiyan MA, Ishiguro M, Nakamura T, Watanabe M, Nagatomo T: Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding. J Pharmacol Sci. 2008 Jan;106(1):114-20. Epub 2008 Jan 11. - Pubmed Yamamoto Y, Koike K: alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta. Br J Pharmacol. 2001 Nov;134(5):1045-54. - Pubmed Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.4278
Potassium voltage-gated channel subfamily H member 2
Name	Potassium voltage-gated channel subfamily H member 2
Gene Name	KCNH2
Pharmacological action	unknown
Actions	inhibitor
References	Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA: Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):462-72. Epub 2004 Apr 20. - Pubmed
DTHybrid score	0.4108
Potassium voltage-gated channel subfamily H member 6
Name	Potassium voltage-gated channel subfamily H member 6
Gene Name	KCNH6
Pharmacological action	unknown
Actions	inhibitor
References	Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA: Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):462-72. Epub 2004 Apr 20. - Pubmed
DTHybrid score	0.3714
Potassium voltage-gated channel subfamily H member 7
Name	Potassium voltage-gated channel subfamily H member 7
Gene Name	KCNH7
Pharmacological action	unknown
Actions	inhibitor
References	Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA: Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):462-72. Epub 2004 Apr 20. - Pubmed
DTHybrid score	0.3711

Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2557

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	substrate,inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed Pan G, Winter TN, Roberts JC, Fairbanks CA, Elmquist WF: Organic cation uptake is enhanced in bcrp1-transfected MDCKII cells. Mol Pharm. 2010 Feb 1;7(1):138-45. - Pubmed
DTHybrid score	0.3236
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed
DTHybrid score	0.3892
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed
DTHybrid score	0.2522
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Takara K, Sakaeda T, Kakumoto M, Tanigawara Y, Kobayashi H, Okumura K, Ohnishi N, Yokoyama T: Effects of alpha-adrenoceptor antagonist doxazosin on MDR1-mediated multidrug resistance and transcellular transport. Oncol Res. 2009;17(11-12):527-33. - Pubmed Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, Brendel C, Ambudkar SV, Neubauer A, Bates SE: Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80. Epub 2010 Apr 27. - Pubmed Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV: Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10594-9. - Pubmed
DTHybrid score	0.5667
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate,inhibitor
References	Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, Brendel C, Ambudkar SV, Neubauer A, Bates SE: Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80. Epub 2010 Apr 27. - Pubmed Ozvegy C, Litman T, Szakacs G, Nagy Z, Bates S, Varadi A, Sarkadi B: Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7. - Pubmed
DTHybrid score	0.2724

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions
References	Not Available
DTHybrid score	0.3236
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions
References	Not Available
DTHybrid score	0.3892
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions
References	Not Available
DTHybrid score	0.2522
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.5667
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.2724

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.3916
4119	Cytochrome P450 2D6	CYP2D6	0.3609
4200	Cytochrome P450 1A2	CYP1A2	0.2708
6016	Cytochrome P450 2C19	CYP2C19	0.213
4757	Cytochrome P450 2C9	CYP2C9	0.1905
4118	Cytochrome P450 3A5	CYP3A5	0.1808
318	Alpha-2A adrenergic receptor	ADRA2A	0.1805
4924	Cytochrome P450 2C8	CYP2C8	0.1454
587	Serum albumin	ALB	0.1326
502	5-hydroxytryptamine 2A receptor	HTR2A	0.1286
831	D(2) dopamine receptor	DRD2	0.1282
6107	Cytochrome P450 3A7	CYP3A7	0.1233
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.1197
193	Beta-1 adrenergic receptor	ADRB1	0.1153
6013	Cytochrome P450 2E1	CYP2E1	0.1149
118	Organic cation/carnitine transporter 2	SLC22A5	0.1128
629	Alpha-2B adrenergic receptor	ADRA2B	0.1119
766	Beta-2 adrenergic receptor	ADRB2	0.1112
6030	Cytochrome P450 2B6	CYP2B6	0.1074
378	Alpha-2C adrenergic receptor	ADRA2C	0.1046
23	D(1A) dopamine receptor	DRD1	0.1045
492	Histamine H1 receptor	HRH1	0.0975
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0892
862	Multidrug resistance-associated protein 1	ABCC1	0.0856
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0853
833	Organic cation/carnitine transporter 1	SLC22A4	0.0844
751	Potassium channel subfamily K member 6	KCNK6	0.0755
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0732
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0724
5718	Cytochrome P450 2A6	CYP2A6	0.0715
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0694
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0693
172	Potassium channel subfamily K member 1	KCNK1	0.0683
713	Sodium-dependent dopamine transporter	SLC6A3	0.0681
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0661
6142	Solute carrier family 22 member 8	SLC22A8	0.0651
824	Sodium-dependent serotonin transporter	SLC6A4	0.0642
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0638
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0625
1898	Cytochrome P450 1B1	CYP1B1	0.0622
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0608
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0605
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0589
776	Bile salt export pump	ABCB11	0.0576
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0565
1729	Solute carrier family 22 member 6	SLC22A6	0.0532
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0521
432	D(4) dopamine receptor	DRD4	0.051
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0506
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0503
3941	Amine oxidase [flavin-containing] A	MAOA	0.0478
131	Synaptic vesicular amine transporter	SLC18A2	0.0476
638	D(3) dopamine receptor	DRD3	0.045
3923	Cholinesterase	BCHE	0.0428
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0396
1517	Beta-3 adrenergic receptor	ADRB3	0.0395
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0391
465	Calmodulin	CALM1	0.0373
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0353
817	DNA topoisomerase 2-alpha	TOP2A	0.0347
2164	Multidrug resistance-associated protein 4	ABCC4	0.0346
6106	Cytochrome P450 2C18	CYP2C18	0.0343
163	D(1B) dopamine receptor	DRD5	0.0342
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0341
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0341
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0339
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0338
233	Potassium channel subfamily K member 2	KCNK2	0.0335
124	Histamine H2 receptor	HRH2	0.0333
828	Phenylalanine-4-hydroxylase	PAH	0.0332
3109	Phenylalanine-4-hydroxylase	phhA	0.0332
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0331
844	Epidermal growth factor receptor	EGFR	0.0324
6148	Multidrug resistance-associated protein 7	ABCC10	0.0319
20	Prostaglandin G/H synthase 1	PTGS1	0.0317
6138	Multidrug resistance protein 3	ABCB4	0.0308
3811	Cytochrome P450 19A1	CYP19A1	0.0308
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0306
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0303
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0301
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.03
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.03
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.03
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.03
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.03
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0299
6143	Solute carrier family 22 member 7	SLC22A7	0.0295
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0282
136	Estrogen receptor	ESR1	0.0273
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0265
7	Nitric oxide synthase, inducible	NOS2	0.0265
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0264
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0264
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0254
1024	Solute carrier family 22 member 11	SLC22A11	0.0253
3939	Amine oxidase [flavin-containing] B	MAOB	0.0253
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0252
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0246
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0246
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0245
4773	Deoxycytidine kinase	DCK	0.024
6182	Cytochrome P450 2J2	CYP2J2	0.0233
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0228
716	5-hydroxytryptamine 7 receptor	HTR7	0.0225
1636	Trace amine-associated receptor 1	TAAR1	0.0224
6137	Multidrug resistance-associated protein 6	ABCC6	0.0224
474	Acetylcholinesterase	ACHE	0.0223
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0221
260	Cytochrome P450 51	ERG11	0.022
761	Cytochrome P450 51	ERG11	0.022
3163	Cytochrome P450 51	cyp51	0.022
1353	DNA topoisomerase 1	TOP1	0.0215
3552	DNA topoisomerase 1	topA	0.0215
6141	Sodium/bile acid cotransporter	SLC10A1	0.0214
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0212
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.021
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.021
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0207
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0207
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0205
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0203
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.02
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0195
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0195
3947	Xanthine dehydrogenase/oxidase	XDH	0.0187
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0187
504	Mast/stem cell growth factor receptor	KIT	0.0184
6136	Multidrug resistance-associated protein 5	ABCC5	0.0182
468	Cytochrome P450 4A11	CYP4A11	0.0182
1757	Myeloperoxidase	MPO	0.0178
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0173
6070	Nischarin	NISCH	0.0172
6014	Cytochrome P450 2A13	CYP2A13	0.0172
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0171
4203	Histamine N-methyltransferase	HNMT	0.017
871	Glucocorticoid receptor	NR3C1	0.0168
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0167
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0165
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0165
5626	Nucleoside diphosphate kinase B	NME2	0.0164
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0163
6432	Transporter	snf	0.0162
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0162
161	Tubulin beta chain	TUBB	0.0162
312	Tubulin beta chain	TUB2	0.0162
6010	Thiamine transporter 1	SLC19A2	0.0159
756	Sex hormone-binding globulin	SHBG	0.0159
4120	NADPH--cytochrome P450 reductase	POR	0.0158
2472	Voltage-gated potassium channel	kcsA	0.0157
6366	Voltage-gated potassium channel	kcsA	0.0157
290	Prostaglandin G/H synthase 2	PTGS2	0.0156
731	HIV-1 protease	HIV-1 protease	0.0151
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0151
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.015
6146	High affinity copper uptake protein 1	SLC31A1	0.0148
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0147
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0147
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0147
869	Estrogen receptor beta	ESR2	0.0147
380	Cytochrome P450 17A1	CYP17A1	0.0147
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0144
175	Thiamin pyrophosphokinase 1	TPK1	0.0142
908	Glutathione S-transferase theta-1	GSTT1	0.0142
183	Vascular endothelial growth factor A	VEGFA	0.0142
164	Histamine H4 receptor	HRH4	0.0141
6163	Copper-transporting ATPase 2	ATP7B	0.0138
6165	Copper-transporting ATPase 1	ATP7A	0.0138
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0138
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0137
291	Nitric-oxide synthase, endothelial	NOS3	0.0137
33	Cystine/glutamate transporter	SLC7A11	0.0137
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0134
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0134
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0133
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0132
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0132
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0132
5294	Nucleoside diphosphate kinase A	NME1	0.0131
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0131
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.013
2449	Tubulin alpha-3 chain	TUBA1A	0.0129
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0128
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
5126	Arginase	rocF	0.0125
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0124
738	Monocarboxylate transporter 1	SLC16A1	0.0124
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0123
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0122
1618	High affinity nerve growth factor receptor	NTRK1	0.0122
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0122
904	Glutathione S-transferase P	GSTP1	0.0121
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0121
3086	Plasmepsin-2	Not Available	0.012
29	Tubulin beta-1 chain	TUBB1	0.012
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0118
696	Kappa-type opioid receptor	OPRK1	0.0118
603	DNA polymerase alpha catalytic subunit	POLA1	0.0118
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0117
1341	Histamine H3 receptor	HRH3	0.0117
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0116
48	Pyridoxal kinase	PDXK	0.0116
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0115
847	Mu-type opioid receptor	OPRM1	0.0113
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0112
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0112
896	Glutathione S-transferase Mu 1	GSTM1	0.0112
4604	Liver carboxylesterase 1	CES1	0.0111
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.011
2499	Tubulin beta-2C chain	TUBB2C	0.011
477	DNA topoisomerase 4 subunit A	parC	0.0108
886	DNA topoisomerase 4 subunit A	parC	0.0108
6226	DNA topoisomerase 4 subunit A	parC	0.0108
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0107
404	DNA gyrase subunit A	gyrA	0.0106
6224	DNA gyrase subunit A	gyrA	0.0106
5787	Angiopoietin-1 receptor	TEK	0.0105
777	Tumor necrosis factor	TNF	0.0105
2539	Tubulin alpha-1 chain	TUBA4A	0.0103
702	UMP-CMP kinase	CMPK1	0.0102
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0101
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.01
117	Sterol O-acyltransferase 1	SOAT1	0.0099
467	Delta-type opioid receptor	OPRD1	0.0098
694	Matrix protein 2	M	0.0098
1374	Natriuretic peptides B	NPPB	0.0098
1827	Gap junction alpha-1 protein	GJA1	0.0098
1908	Vascular cell adhesion protein 1	VCAM1	0.0098
1656	CYP2B protein	CYP2B	0.0098
624	Guanidinoacetate N-methyltransferase	GAMT	0.0097
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
6171	Solute carrier family 28 member 3	SLC28A3	0.0094
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0093
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0091
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0087
614	Progesterone receptor	PGR	0.0087
1192	Sulfotransferase 1A1	SULT1A1	0.0087
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0086
605	Fumarate reductase flavoprotein subunit	frdA	0.0083
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0083
3673	Fumarate reductase flavoprotein subunit	fccA	0.0083
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0083
6549	Fumarate reductase flavoprotein subunit	frdA	0.0083
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0083
26	Vascular endothelial growth factor receptor 3	FLT4	0.0083
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0082
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0081
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0081
2300	Lysozyme	E	0.0081
3633	Lysozyme	R	0.0081
5597	Lysozyme	17	0.0081
6111	DNA polymerase epsilon subunit 4	POLE4	0.008
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.008
6112	DNA polymerase epsilon subunit 3	POLE3	0.008
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.008
6110	DNA polymerase epsilon subunit 2	POLE2	0.008
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.008
32	Vascular endothelial growth factor receptor 1	FLT1	0.0079
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0079
461	Glycine receptor subunit alpha-3	GLRA3	0.0079
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0079
737	Mineralocorticoid receptor	NR3C2	0.0079
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0079
3810	Catechol O-methyltransferase	COMT	0.0078
407	Vascular endothelial growth factor receptor 2	KDR	0.0077
1830	5'-nucleotidase	NT5E	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
992	Protein tyrosine kinase 2 beta	PTK2B	0.0076
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0075
146	Androgen receptor	AR	0.0075
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0074
1864	RET proto-oncogene	RET	0.0074
3611	Cytidine deaminase	cdd	0.0074
3707	Cytidine deaminase	cdd	0.0074
4211	Cytidine deaminase	CDA	0.0074
125	DNA polymerase beta	POLB	0.0074
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0074
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0074
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0074
338	DNA polymerase	UL30	0.0073
379	DNA polymerase	UL54	0.0073
697	DNA polymerase	ORF28	0.0073
2482	DNA polymerase	43	0.0073
4104	DNA polymerase	BALF5	0.0073
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0073
613	Atrial natriuretic peptide receptor A	NPR1	0.0072
6220	Aryl hydrocarbon receptor	AHR	0.0072
373	Transthyretin	TTR	0.0071
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0071
6031	Cytochrome P450 3A43	CYP3A43	0.007
3426	Glutamine synthetase	glnA	0.007
3987	Glutamine synthetase	GLUL	0.007
6151	Monocarboxylate transporter 10	SLC16A10	0.007
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.007
6085	Fatty acid-binding protein, intestinal	FABP2	0.007
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.007
3927	Choline transporter-like protein 3	SLC44A3	0.007
3926	Choline transporter-like protein 2	SLC44A2	0.007
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.007
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.007
1686	Choline transporter-like protein 1	SLC44A1	0.007
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.007
861	Choline kinase alpha	CHKA	0.007
769	High-affinity choline transporter 1	SLC5A7	0.007
3925	Choline transporter-like protein 4	SLC44A4	0.007
700	Choline dehydrogenase, mitochondrial	CHDH	0.007
576	Choline O-acetyltransferase	CHAT	0.007
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.007
3922	Phospholipase D2	PLD2	0.007
3924	Phospholipase D1	PLD1	0.007
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.007
1770	Phospholipase C	PLCL1	0.007
2841	Phospholipase C	plc	0.007
976	Platelet glycoprotein IX	GP9	0.0069
5682	Ribonuclease pancreatic	RNASE1	0.0069
1050	Bile salt sulfotransferase	SULT2A1	0.0068
6167	Organic solute transporter subunit beta	OSTB	0.0068
6166	Organic solute transporter subunit alpha	OSTA	0.0067
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0067
4192	DNA topoisomerase 2-beta	TOP2B	0.0066
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0066
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0066
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0066
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0064
106	Cannabinoid receptor 2	CNR2	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
244	Angiotensin-converting enzyme	ACE	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0062
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0062
153	Dopamine beta-hydroxylase	DBH	0.0061
70	Type-1 angiotensin II receptor	AGTR1	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
68	Cannabinoid receptor 1	CNR1	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
768	FK506-binding protein 1A	FKBP1A	0.006
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0058
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0058
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0058
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0058
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0058
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0058
790	DNA polymerase subunit alpha B	POLA2	0.0058
1629	Transcription factor AP-1	JUN	0.0058
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0057
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0057
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0056
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0056
6766	O-GlcNAcase BT_4395	BT_4395	0.0056
3932	Glutathione S-transferase A2	GSTA2	0.0056
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0056
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0055
122	P2Y purinoceptor 12	P2RY12	0.0055
165	FL cytokine receptor	FLT3	0.0054
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0054
1852	Microtubule-associated protein 2	MAP2	0.0053
1650	Heme carrier protein 1	SLC46A1	0.0053
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
823	Fibroblast growth factor receptor 2	FGFR2	0.0052
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
94	5-hydroxytryptamine 4 receptor	HTR4	0.0051
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.005
469	Annexin A1	ANXA1	0.005
820	Glycine receptor subunit alpha-2	GLRA2	0.005
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.005
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0049
1714	Mitogen-activated protein kinase 3	MAPK3	0.0049
6149	Solute carrier family 22 member 10	SLC22A10	0.0049
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0048
936	Ephrin type-A receptor 2	EPHA2	0.0048
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0048
4217	Telomerase reverse transcriptase	TERT	0.0048
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0047
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0046
6859	Protein S100-A4	S100A4	0.0046
277	Purine nucleoside phosphorylase	PNP	0.0046
2870	Purine nucleoside phosphorylase	punA	0.0046
2945	Purine nucleoside phosphorylase	punA	0.0046
4659	Purine nucleoside phosphorylase	TM_1596	0.0046
4825	Purine nucleoside phosphorylase	TTHA1435	0.0046
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0046
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0046
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0046
3856	Fibroblast growth factor receptor 3	FGFR3	0.0046
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0046
723	Cytosolic phospholipase A2	PLA2G4A	0.0046
1010	Cytochrome P450 51A1	CYP51A1	0.0046
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0044
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0044
1820	Beta-nerve growth factor	NGF	0.0044
1176	Mitogen-activated protein kinase 1	MAPK1	0.0044
4228	Keratin, type II cytoskeletal 7	KRT7	0.0044
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0044
239	Coagulation factor X	F10	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0043
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0043
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0043
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0042
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0042
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0041
5923	Microtubule-associated protein tau	MAPT	0.0041
5924	Microtubule-associated protein 4	MAP4	0.0041
2112	Toll-like receptor 9	TLR9	0.0041
511	5-hydroxytryptamine 1F receptor	HTR1F	0.004
123	Diamine acetyltransferase 1	SAT1	0.004
4103	Proteasome subunit beta type 2	PSMB2	0.004
4102	Proteasome subunit beta type 5	PSMB5	0.004
4101	Proteasome subunit beta type 1	PSMB1	0.004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.004
273	Apoptosis regulator Bcl-2	BCL2	0.004
6211	Tubulin epsilon chain	TUBE1	0.0039
6212	Tubulin gamma-1 chain	TUBG1	0.0039
6210	Tubulin delta chain	TUBD1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1178	Adenosine A2a receptor	ADORA2A	0.0038
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0038
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0038
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0038
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0037
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0037
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0037
2320	Thymidine kinase, cytosolic	TK1	0.0037
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0037
952	Dipeptidyl peptidase 4	DPP4	0.0037
24	Thymidylate synthase	TMP1	0.0037
359	Thymidylate synthase	TYMS	0.0037
2626	Thymidylate synthase	thyA	0.0037
2729	Thymidylate synthase	thyA	0.0037
5352	Thymidylate synthase	THYA	0.0037
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0037
489	Monocarboxylate transporter 2	SLC16A7	0.0036
527	Prostacyclin receptor	PTGIR	0.0036
84	Nuclear receptor 0B1	NR0B1	0.0036
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0036
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0036
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0036
1074	Urokinase-type plasminogen activator	PLAU	0.0036
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0036
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0035
484	Tyrosine-protein kinase ABL2	ABL2	0.0035
3809	Estrogen-related receptor gamma	ESRRG	0.0035
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0035
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0035
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0035
293	Gamma-glutamyl hydrolase	GGH	0.0035
6218	Pannexin-1	PANX1	0.0034
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0034
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0033
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
1760	Aminopeptidase N	ANPEP	0.0032
6843	Aminopeptidase N	pepN	0.0032
1569	G1/S-specific cyclin-D1	CCND1	0.0032
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0032
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
4311	tRNA	TRDMT1	0.0031
4325	tRNA	trmD	0.0031
4328	tRNA	trmD	0.0031
2599	Tyrosine-protein kinase HCK	HCK	0.003
6824	Tyrosine-protein kinase Lyn	LYN	0.003
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0029
3587	Gastrotropin	FABP6	0.0029
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0029
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0029
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0029
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0029
16	Adenosine A1 receptor	ADORA1	0.0029
683	Potassium transporter	GK0582	0.0029
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
6043	Putative G-protein coupled receptor 44	GPR44	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4237	50S ribosomal protein L22	rplV	0.0027
2236	Casein kinase II subunit alpha	CSNK2A1	0.0027
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0027
818	50S ribosomal protein L10	rplJ	0.0026
275	Arachidonate 5-lipoxygenase	ALOX5	0.0026
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0026
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0026
5934	Cytochrome P450 26A1	CYP26A1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0026
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6837	Serine/threonine-protein kinase 17B	STK17B	0.0025
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
185	Vasopressin V1a receptor	AVPR1A	0.0024
319	Opioid receptor, sigma 1	OPRS1	0.0024
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0024
569	Retinal dehydrogenase 2	ALDH1A2	0.0024
322	Vasopressin V2 receptor	AVPR2	0.0024
2216	Fibroblast growth factor receptor 4	FGFR4	0.0024
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
6228	Nuclear receptor coactivator 1	NCOA1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0023
6241	Nuclear receptor coactivator 2	NCOA2	0.0023
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0022
611	Retinal dehydrogenase 1	ALDH1A1	0.0022
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0022
814	Ryanodine receptor 1	RYR1	0.0022
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0022
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0021
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0021
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0021
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0021
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
564	Cellular retinoic acid-binding protein 1	CRABP1	0.002
2240	Cell division protein kinase 2	CDK2	0.002
1058	Cell division protein kinase 5	CDK5	0.002
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.002
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0019
581	Cytochrome P450 2R1	CYP2R1	0.0019
295	Carbonic anhydrase 1	CA1	0.0019
5798	Mitogen-activated protein kinase 11	MAPK11	0.0019
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0019
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0019
3957	Adenosine deaminase	ADA	0.0019
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0019
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0019
3830	Calreticulin	CALR	0.0018
365	Dihydrofolate reductase	DHFR	0.0018
2381	Dihydrofolate reductase	DFR1	0.0018
2833	Dihydrofolate reductase	Not Available	0.0018
2931	Dihydrofolate reductase	folA	0.0018
3544	Dihydrofolate reductase	folA	0.0018
3682	Dihydrofolate reductase	folA	0.0018
6642	Dihydrofolate reductase	folA	0.0018
6756	Dihydrofolate reductase	dfrA	0.0018
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0018
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0018
780	Retinoic acid receptor RXR-gamma	RXRG	0.0018
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0018
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0018
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0018
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0018
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0018
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0018
1992	Vitamin D-binding protein	GC	0.0018
2408	Tyrosine-protein kinase SYK	SYK	0.0018
760	Fibroblast growth factor 1	FGF1	0.0017
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0017
6034	Hydroxyindole O-methyltransferase	ASMT	0.0017
6035	Nuclear receptor ROR-beta	RORB	0.0017
6036	Eosinophil peroxidase	EPX	0.0017
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0017
6020	Aldehyde oxidase	AOX1	0.0017
594	Thyroxine-binding globulin	SERPINA7	0.0017
400	Coagulation factor IX	F9	0.0017
5461	Coagulation factor IX	F9	0.0017
4226	Uridine phosphorylase 2	UPP2	0.0017
444	Alcohol dehydrogenase 1B	ADH1B	0.0017
88	Retinoic acid receptor RXR-beta	RXRB	0.0017
4122	Histone deacetylase 2	HDAC2	0.0016
1275	Estrogen sulfotransferase	SULT1E1	0.0016
162	Retinoic acid receptor gamma-1	RARG	0.0016
5300	Antigen peptide transporter 1	TAP1	0.0016
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0016
4225	Uridine phosphorylase 1	UPP1	0.0016
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0016
758	Thyroid hormone receptor alpha	THRA	0.0016
822	Aldose reductase	AKR1B1	0.0016
6102	Arylamine N-acetyltransferase 2	NAT2	0.0016
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0015
604	Vitamin K-dependent protein Z	PROZ	0.0015
6755	Poliovirus receptor	PVR	0.0015
765	Indoleamine 2,3-dioxygenase	IDO1	0.0015
251	Alcohol dehydrogenase 1A	ADH1A	0.0015
54	Prothrombin	F2	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0015
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0015
413	Amidophosphoribosyltransferase	PPAT	0.0014
2515	Amidophosphoribosyltransferase	purF	0.0014
3714	Amidophosphoribosyltransferase	purF	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
268	Adenosine A2b receptor	ADORA2B	0.0014
422	Vitamin K-dependent protein C	PROC	0.0014
1245	Vitamin K-dependent protein S	PROS1	0.0014
5818	Folate receptor alpha	FOLR1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
346	Thyroid hormone receptor beta-1	THRB	0.0014
571	Melatonin receptor type 1A	MTNR1A	0.0014
362	Melatonin receptor type 1B	MTNR1B	0.0014
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0013
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0013
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0013
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0013
517	Alcohol dehydrogenase 1C	ADH1C	0.0013
6168	Solute carrier family 22 member 16	SLC22A16	0.0013
856	Vitamin D3 receptor	VDR	0.0013
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0012
267	Plasminogen activator inhibitor 1	SERPINE1	0.0012
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
3639	Thymidine phosphorylase	deoA	0.0012
3936	Thymidine phosphorylase	TYMP	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0012
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0012
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
634	Squalene monooxygenase	SQLE	0.0011
7196	Squalene monooxygenase	ERG1	0.0011
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0011
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
798	Osteocalcin	BGLAP	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
6221	Steroid hormone receptor ERR1	ESRRA	0.0011
3007	Carbonic anhydrase 12	CA12	0.0011
4205	Carbonic anhydrase 9	CA9	0.0011
6459	Glycodelin	PAEP	0.0011
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0011
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0011
232	Corticosteroid-binding globulin	SERPINA6	0.0011
427	Substance-P receptor	TACR1	0.0011
6126	Carbonic anhydrase 7	CA7	0.001
144	Hemoglobin subunit alpha	HBA1	0.001
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.001
369	Coagulation factor VII	F7	0.001
6174	50S ribosomal protein L32	rpmF	0.001
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.001
3937	Fatty-acid amide hydrolase	FAAH	0.001
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.001
811	Translocator protein	TSPO	0.001
345	Plasma retinol-binding protein	RBP4	0.001
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
199	Monocarboxylate transporter 8	SLC16A2	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
76	Nitric-oxide synthase, brain	NOS1	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0009
1291	cAMP response element-binding protein	CREB1	0.0009
1525	Heparin-binding growth factor 2	FGF2	0.0009
4210	Toll-like receptor 4	TLR4	0.0009
1262	Corticotropin-lipotropin	POMC	0.0009
592	Carbonic anhydrase 4	CA4	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
459	Retinoic acid receptor RXR-alpha	RXRA	0.0007
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
921	Glutamate receptor 2	GRIA2	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
1630	Integrin beta-2	ITGB2	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
6677	Myelin P2 protein	PMP2	0.0006
357	Carbonic anhydrase 2	CA2	0.0006
174	Sigma 1-type opioid receptor	SIGMAR1	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
6044	Serum paraoxonase/lactonase 3	PON3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
2021	Thrombomodulin	THBD	0.0005
2207	Rhodopsin	RHO	0.0005
572	Integrin alpha-L	ITGAL	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3221	Cytochrome c4	cc4	0.0005
4692	A/G-specific adenine glycosylase	mutY	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
284	DNA-directed RNA polymerase beta chain	rpoB	0.0003
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00457 - Prazosin

Targets

Enzymes

Transporters

Carriers

Predictions