DT-Web

DB00706 - Tamsulosin


Identification
Name Tamsulosin
Accession Number DB00706 (APRD00036)
Type small molecule
Description Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 408.512
Groups approved
Monoisotopic Weight 408.171892706
Pharmacology
Indication Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream...etc.)
Mechanism of action Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men.
Absorption Absorption of tamsulosin HCI from capsules 0.4 mg is essentially complete (>90%) following oral administration under fasting conditions.
Protein binding 94%-99%
Biotransformation Tamsulosin HCI is extensively metabolized by cytochrome P450 enzymes in the liver, however, the pharmacokinetic profile of the metabolites in humans has not been established.
Route of elimination Tamsulosin hydrochloride is extensively metabolized by cytochrome P450 enzymes in the liver and less than 10% of the dose is excreted in urine unchanged. The metabolites of tamsulosin hydrochloride undergo extensive conjugation to glucuronide or sulfate prior to renal excretion. On administration of the radiolabeled dose of tamsulosin hydrochloride to four healthy volunteers, 97% of the administered radioactivity was recovered, with urine (76%) representing the primary route of excretion compared to feces (21%) over 168 hours.
Toxicity LD50 = 650 mg/kg (in rats)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Alfuzosin Concomitant use of alpha1-adrenergic antagonists, Tamsulosin and Alfuzosin, may result in additive antihypertensive effects. Combination therapy is not recommended.
Amiodarone Amiodarone, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Amiodarone is initiated, discontinued, or dose changed.
Amprenavir Amprenavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Amprenavir is initiated, discontinued, or dose changed.
Aprepitant Aprepitant, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Aprepitant is initiated, discontinued, or dose changed.
Atazanavir Atazanvir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Atazanavir is initiated, discontinued, or dose changed.
Caffeine Caffeine, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Caffeine is initiated, discontinued, or dose changed.
Chloroquine Chloroquine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Chloroquine is initiated, discontinued, or dose changed.
Chlorpromazine Chlorpromazine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Chlorpromazine is initiated, discontinued, or dose changed.
Cimetidine Cimetidine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Cimetidine is initiated, discontinued, or dose changed.
Cinacalcet Cinacalcet, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Cinacalcet is initiated, discontinued, or dose changed.
Clarithromycin Clarithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Clarithromycin is initiated, discontinued, or dose changed.
Clomipramine Clomipramine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Clomipramine is initiated, discontinued, or dose changed.
Clotrimazole Clotrimazole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Clotrimazole is initiated, discontinued, or dose changed.
Clozapine Clozapine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Clozapine is initiated, discontinued, or dose changed.
Cocaine Cocaine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Cocaine is initiated, discontinued, or dose changed.
Conivaptan Conivaptan, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Conivaptan is initiated, discontinued, or dose changed.
Cyclosporine Cyclosporine, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Cyclosporine is initiated, discontinued, or dose changed.
Dapiprazole Concomitant use of alpha1-adrenergic antagonists, Tamsulosin and Dapiprazole, may result in additive antihypertensive effects. Combination therapy is not recommended.
Darifenacin Darifenacin, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Darifenacin is initiated, discontinued, or dose changed.
Darunavir Darunavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Darunavir is initiated, discontinued, or dose changed.
Delavirdine Delavirdine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Delavirdine is initiated, discontinued, or dose changed.
Desipramine Desipramine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Desipramine is initiated, discontinued, or dose changed.
Diltiazem Diltiazem, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Diltiazem is initiated, discontinued, or dose changed.
Diphenhydramine Diphenhydramine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Diphenhydramine is initiated, discontinued, or dose changed.
Doxazosin Concomitant use of alpha1-adrenergic antagonists, Tamsulosin and Doxazosin, may result in additive antihypertensive effects. Combination therapy is not recommended.
Doxycycline Doxycycline, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Doxycycline is initiated, discontinued, or dose changed.
Duloxetine Duloxetine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Duloxetine is initiated, discontinued, or dose changed.
Efavirenz Efavirenz, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Efavirenz is initiated, discontinued, or dose changed.
Erythromycin Erythromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Erythromycin is initiated, discontinued, or dose changed.
Etravirine Etravirine, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Etravirine is initiated, discontinued, or dose changed.
Fluconazole Fluconzole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Fluconazole is initiated, discontinued, or dose changed.
Fluoxetine Fluoxetine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Fluoxetine is initiated, discontinued, or dose changed.
Fosamprenavir Fosamprenavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Fosamprenavir is initiated, discontinued, or dose changed.
Haloperidol Haloperidol, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Haloperidol is initiated, discontinued, or dose changed.
Imatinib Imatinib, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Imatinib is initiated, discontinued, or dose changed.
Imipramine Imipramine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Imipramine is initiated, discontinued, or dose changed.
Indinavir Indinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Indinavir is initiated, discontinued, or dose changed.
Isoniazid Isoniazid, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Isoniazid is initiated, discontinued, or dose changed.
Itraconazole Itraconazole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Itraconazole is initiated, discontinued, or dose changed.
Ketoconazole Ketoconazole, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Ketoconzole is initiated, discontinued, or dose changed.
Lapatinib Lapatinib, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Lapatinib is initiated, discontinued, or dose changed.
Lidocaine Lidocaine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Lidocaine is initiated, discontinued, or dose changed.
Lopinavir Lopinavir, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Lopinavir is initiated, discontinued, or dose changed.
Methadone Methadone, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Methadone is initiated, discontinued, or dose changed.
Methimazole Methimazole, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Methimazole is initiated, discontinued, or dose changed.
Metronidazole Metronidazole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Metronidazole is initiated, discontinued, or dose changed.
Miconazole Miconazole, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Miconazole is initiated, discontinued, or dose changed.
Nefazodone Nefazodone, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Nefazodone is initiated, discontinued, or dose changed.
Nelfinavir Nelfinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Nelfinavir is initiated, discontinued, or dose changed.
Nicardipine Nicardipine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Nicardipine is initiated, discontinued, or dose changed.
Nilotinib Nilotinib, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Nilotinib is initiated, discontinued, or dose changed.
Norfloxacin Norfloxacin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Norfloxacin is initiated, discontinued, or dose changed.
Paroxetine Paroxetine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Paroxetine is initiated, discontinued, or dose changed.
Pergolide Pergolide, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Pergolide is initiated, discontinued, or dose changed.
Phenoxybenzamine Concomitant use of alpha1-adrenergic antagonists, Tamsulosin and Phenoxybenzamine, may result in additive antihypertensive effects. Combination therapy is not recommended.
Phentolamine Concomitant use of alpha1-adrenergic antagonists, Tamsulosin and Phentolamine, may result in additive antihypertensive effects. Combination therapy is not recommended.
Pioglitazone Pioglitazone, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Pioglitazone is initiated, discontinued, or dose changed.
Posaconazole Posaconazole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Posaconazole is initiated, discontinued, or dose changed.
Prazosin Concomitant use of alpha1-adrenergic antagonists, Tamsulosin and Prazosin, may result in additive antihypertensive effects. Combination therapy is not recommended.
Pyrimethamine Pyrimethamine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Pyrimethamine is initiated, discontinued, or dose changed.
Quinidine Quinidine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Quinidine is initiated, discontinued, or dose changed.
Quinine Quinine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Quinine is initiated, discontinued, or dose changed.
Ranolazine Ranolazine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Ranolazine is initiated, discontinued, or dose changed.
Ritonavir Ritonavir, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Ritonavir is initiated, discontinued, or dose changed.
Saquinavir Saquinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Saquinavir is initiated, discontinued, or dose changed.
Sertraline Sertraline, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Sertraline is initiated, discontinued, or dose changed.
Silodosin Additive antihypertensive effects may occur. Increase risk of orthostatic hypotension and syncope. Concomitant therapy is not recommended.
Sitaxentan Sitaxsentan, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Sitaxsentan is initiated, discontinued, or dose changed.
Tadalafil Tadalafil may enhance the hypotensive effect of Tamsulosin. Monitor for hypotension during concomitant therapy.
Telithromycin Telithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic/adverse effects of Tamsulosin if Telithromycin is initiated, discontinued, or dose changed.
Terazosin Concomitant use of alpha1-adrenergic antagonists, Tamsulosin and Terazosin, may result in additive antihypertensive effects. Combination therapy is not recommended.
Terbinafine Terbinafine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Consider alternate therapy or monitor for changes in therapeutic/adverse effects of Tamsulosin if Terbinafine is initiated, discontinued, or dose changed.
Tetracycline Tetracycline, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Tetracycline is initiated, discontinued, or dose changed.
Thioridazine Thioridazine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Thioridazine is initiated, discontinued, or dose changed.
Ticlopidine Ticlopidine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Ticlopidine is initiated, discontinued, or dose changed.
Tranylcypromine Tranylcypromine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Tranylcypromine is initiated, discontinued, or dose changed.
Trazodone Trazodone, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Trazodone is initiated, discontinued, or dose changed.
Vardenafil Additive hypotensive effects of the PDE5 inhibitor, Vardenafil, and alpha1-blocker, Tamsulosin, may occur. Monitor for hypotension during concomitant therapy.
Verapamil Verapamil, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Verapamil is initiated, discontinued, or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of tamsulosin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of tamsulosin if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take 30 minutes after a meal (always after the same meal). Taking the drug with food minimizes plasma levels variations.

Targets


Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Abrams P, Speakman M, Stott M, Arkell D, Pocock R: A dose-ranging study of the efficacy and safety of tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist, in patients with benign prostatic obstruction (symptomatic benign prostatic hyperplasia). Br J Urol. 1997 Oct;80(4):587-96. - Pubmed
  • Na YJ, Guo YL, Gu FL: Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group. J Med. 1998;29(5-6):289-304. - Pubmed
  • Lee E, Lee C: Clinical comparison of selective and non-selective alpha 1A-adrenoreceptor antagonists in benign prostatic hyperplasia: studies on tamsulosin in a fixed dose and terazosin in increasing doses. Br J Urol. 1997 Oct;80(4):606-11. - Pubmed
  • Chapple CR, Wyndaele JJ, Nordling J, Boeminghaus F, Ypma AF, Abrams P: Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group. Eur Urol. 1996;29(2):155-67. - Pubmed
  • Schulman CC, Cortvriend J, Jonas U, Lock TM, Vaage S, Speakman MJ: Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. Analysis of a multinational, multicentre, open-label study assessing the long-term efficacy and safety in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group. Eur Urol. 1996;29(2):145-54. - Pubmed
  • Chen Y, Li H, Dong Q, Wang KJ: Blockade of alpha 1A-adrenoceptor: a novel possible strategy for male contraception. Med Hypotheses. 2009 Aug;73(2):140-1. Epub 2009 May 8. - Pubmed
  • Michel MC, de la Rosette JJ: Efficacy and safety of tamsulosin in the treatment of urological diseases. Expert Opin Pharmacother. 2004 Jan;5(1):151-60. - Pubmed
DTHybrid score 0.5097
Alpha-1D adrenergic receptor
Name Alpha-1D adrenergic receptor
Gene Name ADRA1D
Pharmacological action unknown
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Noble AJ, Chess-Williams R, Couldwell C, Furukawa K, Uchyiuma T, Korstanje C, Chapple CR: The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes. Br J Pharmacol. 1997 Jan;120(2):231-8. - Pubmed
  • Lowe FC: Summary of clinical experiences with tamsulosin for the treatment of benign prostatic hyperplasia. Rev Urol. 2005;7 Suppl 4:S13-21. - Pubmed
  • Tomiyama Y, Tatemichi S, Tadachi M, Kobayashi S, Hayashi M, Kobayashi M, Yamazaki Y, Shibata N: [Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia] Yakugaku Zasshi. 2006 Mar;126 Spec no.:225-30. - Pubmed
  • Ishiguro M, Futabayashi Y, Ohnuki T, Ahmed M, Muramatsu I, Nagatomo T: Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling. Life Sci. 2002 Oct 11;71(21):2531-41. - Pubmed
  • Taguchi K, Saitoh M, Sato S, Asano M, Michel MC: Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J Pharmacol Exp Ther. 1997 Jan;280(1):1-5. - Pubmed
  • Michel MC, de la Rosette JJ: Efficacy and safety of tamsulosin in the treatment of urological diseases. Expert Opin Pharmacother. 2004 Jan;5(1):151-60. - Pubmed
DTHybrid score 0.2843
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action unknown
Actions antagonist
References
  • Ishiguro M, Futabayashi Y, Ohnuki T, Ahmed M, Muramatsu I, Nagatomo T: Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling. Life Sci. 2002 Oct 11;71(21):2531-41. - Pubmed
  • Michel MC, Hanft G, Gross G: Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle. Br J Pharmacol. 1994 Feb;111(2):539-46. - Pubmed
  • Taguchi K, Saitoh M, Sato S, Asano M, Michel MC: Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J Pharmacol Exp Ther. 1997 Jan;280(1):1-5. - Pubmed
  • Richardson CD, Donatucci CF, Page SO, Wilson KH, Schwinn DA: Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes. Prostate. 1997 Sep 15;33(1):55-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Michel MC, de la Rosette JJ: Efficacy and safety of tamsulosin in the treatment of urological diseases. Expert Opin Pharmacother. 2004 Jan;5(1):151-60. - Pubmed
DTHybrid score 0.3883

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.455
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4045

Carriers


Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.1881
318 Alpha-2A adrenergic receptor ADRA2A 0.1656
4200 Cytochrome P450 1A2 CYP1A2 0.1589
4757 Cytochrome P450 2C9 CYP2C9 0.14
6016 Cytochrome P450 2C19 CYP2C19 0.138
502 5-hydroxytryptamine 2A receptor HTR2A 0.1199
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1182
4118 Cytochrome P450 3A5 CYP3A5 0.1153
831 D(2) dopamine receptor DRD2 0.1136
587 Serum albumin ALB 0.0994
492 Histamine H1 receptor HRH1 0.0982
23 D(1A) dopamine receptor DRD1 0.0949
4924 Cytochrome P450 2C8 CYP2C8 0.0922
629 Alpha-2B adrenergic receptor ADRA2B 0.0904
320 5-hydroxytryptamine 1A receptor HTR1A 0.0859
6107 Cytochrome P450 3A7 CYP3A7 0.0818
6030 Cytochrome P450 2B6 CYP2B6 0.0768
378 Alpha-2C adrenergic receptor ADRA2C 0.0756
103 Muscarinic acetylcholine receptor M1 CHRM1 0.074
6013 Cytochrome P450 2E1 CYP2E1 0.0734
590 5-hydroxytryptamine 2C receptor HTR2C 0.0732
766 Beta-2 adrenergic receptor ADRB2 0.0728
193 Beta-1 adrenergic receptor ADRB1 0.072
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0694
824 Sodium-dependent serotonin transporter SLC6A4 0.0689
713 Sodium-dependent dopamine transporter SLC6A3 0.0654
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0622
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0598
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0583
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0582
6145 Solute carrier family 22 member 1 SLC22A1 0.0565
432 D(4) dopamine receptor DRD4 0.0515
6024 Cytochrome P450 1A1 CYP1A1 0.051
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0485
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0485
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0432
6144 Solute carrier family 22 member 2 SLC22A2 0.0424
638 D(3) dopamine receptor DRD3 0.0414
725 5-hydroxytryptamine 1D receptor HTR1D 0.0392
220 Sodium channel protein type 5 subunit alpha SCN5A 0.039
885 5-hydroxytryptamine 1B receptor HTR1B 0.038
3941 Amine oxidase [flavin-containing] A MAOA 0.0378
131 Synaptic vesicular amine transporter SLC18A2 0.0353
5718 Cytochrome P450 2A6 CYP2A6 0.0343
163 D(1B) dopamine receptor DRD5 0.0328
1256 5-hydroxytryptamine 6 receptor HTR6 0.03
6147 Solute carrier family 22 member 3 SLC22A3 0.0272
118 Organic cation/carnitine transporter 2 SLC22A5 0.0263
716 5-hydroxytryptamine 7 receptor HTR7 0.0258
1517 Beta-3 adrenergic receptor ADRB3 0.0256
465 Calmodulin CALM1 0.0252
862 Multidrug resistance-associated protein 1 ABCC1 0.0249
20 Prostaglandin G/H synthase 1 PTGS1 0.0245
828 Phenylalanine-4-hydroxylase PAH 0.0238
3109 Phenylalanine-4-hydroxylase phhA 0.0238
847 Mu-type opioid receptor OPRM1 0.0236
6138 Multidrug resistance protein 3 ABCB4 0.0235
436 5-hydroxytryptamine 2B receptor HTR2B 0.0234
341 5-hydroxytryptamine 3 receptor HTR3A 0.0228
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0222
6106 Cytochrome P450 2C18 CYP2C18 0.0215
3923 Cholinesterase BCHE 0.0214
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0195
696 Kappa-type opioid receptor OPRK1 0.0189
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0188
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0185
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0184
467 Delta-type opioid receptor OPRD1 0.0183
871 Glucocorticoid receptor NR3C1 0.0182
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0177
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0172
731 HIV-1 protease HIV-1 protease 0.0158
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0157
3811 Cytochrome P450 19A1 CYP19A1 0.0155
528 5-hydroxytryptamine 1E receptor HTR1E 0.0155
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0153
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0149
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0149
844 Epidermal growth factor receptor EGFR 0.0147
833 Organic cation/carnitine transporter 1 SLC22A4 0.0145
1898 Cytochrome P450 1B1 CYP1B1 0.0143
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0143
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0142
1636 Trace amine-associated receptor 1 TAAR1 0.0134
3939 Amine oxidase [flavin-containing] B MAOB 0.0133
1729 Solute carrier family 22 member 6 SLC22A6 0.0131
776 Bile salt export pump ABCB11 0.0128
124 Histamine H2 receptor HRH2 0.0127
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0127
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0122
1656 CYP2B protein CYP2B 0.0118
474 Acetylcholinesterase ACHE 0.0118
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0115
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.011
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0109
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0109
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0107
290 Prostaglandin G/H synthase 2 PTGS2 0.0107
136 Estrogen receptor ESR1 0.0107
6164 POU domain, class 5, transcription factor 1 POU5F1 0.01
2164 Multidrug resistance-associated protein 4 ABCC4 0.0099
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0099
380 Cytochrome P450 17A1 CYP17A1 0.0095
233 Potassium channel subfamily K member 2 KCNK2 0.0093
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0092
6432 Transporter snf 0.0089
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0089
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0087
1050 Bile salt sulfotransferase SULT2A1 0.0083
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0081
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0081
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0081
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.008
260 Cytochrome P450 51 ERG11 0.0079
761 Cytochrome P450 51 ERG11 0.0079
3163 Cytochrome P450 51 cyp51 0.0079
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0078
1618 High affinity nerve growth factor receptor NTRK1 0.0076
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0075
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0075
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0075
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0075
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0074
6142 Solute carrier family 22 member 8 SLC22A8 0.0074
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
614 Progesterone receptor PGR 0.0072
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0072
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0072
183 Vascular endothelial growth factor A VEGFA 0.0072
6031 Cytochrome P450 3A43 CYP3A43 0.0071
817 DNA topoisomerase 2-alpha TOP2A 0.007
6182 Cytochrome P450 2J2 CYP2J2 0.0069
3947 Xanthine dehydrogenase/oxidase XDH 0.0069
6151 Monocarboxylate transporter 10 SLC16A10 0.0068
768 FK506-binding protein 1A FKBP1A 0.0068
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0066
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0066
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0065
1757 Myeloperoxidase MPO 0.0064
5787 Angiopoietin-1 receptor TEK 0.0063
4120 NADPH--cytochrome P450 reductase POR 0.0062
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0062
952 Dipeptidyl peptidase 4 DPP4 0.0061
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0061
504 Mast/stem cell growth factor receptor KIT 0.0061
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0059
161 Tubulin beta chain TUBB 0.0058
312 Tubulin beta chain TUB2 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0057
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0057
6506 Stathmin-4 STMN4 0.0055
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0054
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0054
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0054
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0054
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0053
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0053
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0052
2112 Toll-like receptor 9 TLR9 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.005
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6143 Solute carrier family 22 member 7 SLC22A7 0.0049
468 Cytochrome P450 4A11 CYP4A11 0.0049
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0048
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0048
146 Androgen receptor AR 0.0048
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0046
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0045
228 Beta platelet-derived growth factor receptor PDGFRB 0.0045
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0044
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0044
3426 Glutamine synthetase glnA 0.0043
3987 Glutamine synthetase GLUL 0.0043
6141 Sodium/bile acid cotransporter SLC10A1 0.0043
122 P2Y purinoceptor 12 P2RY12 0.0043
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0041
94 5-hydroxytryptamine 4 receptor HTR4 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
856 Vitamin D3 receptor VDR 0.004
29 Tubulin beta-1 chain TUBB1 0.004
738 Monocarboxylate transporter 1 SLC16A1 0.004
4604 Liver carboxylesterase 1 CES1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0039
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0039
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0039
814 Ryanodine receptor 1 RYR1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0039
1360 Sphingomyelin phosphodiesterase SMPD1 0.0038
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0038
592 Carbonic anhydrase 4 CA4 0.0038
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0038
6220 Aryl hydrocarbon receptor AHR 0.0038
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0038
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0038
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0037
6148 Multidrug resistance-associated protein 7 ABCC10 0.0037
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
164 Histamine H4 receptor HRH4 0.0037
295 Carbonic anhydrase 1 CA1 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
407 Vascular endothelial growth factor receptor 2 KDR 0.0036
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0035
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0035
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0035
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0035
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0035
6859 Protein S100-A4 S100A4 0.0035
939 50S ribosomal protein L3 rplC 0.0035
811 Translocator protein TSPO 0.0035
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0034
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0034
6020 Aldehyde oxidase AOX1 0.0033
373 Transthyretin TTR 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0033
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0032
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0032
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
777 Tumor necrosis factor TNF 0.0032
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0032
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
6014 Cytochrome P450 2A13 CYP2A13 0.0031
365 Dihydrofolate reductase DHFR 0.0031
2381 Dihydrofolate reductase DFR1 0.0031
2833 Dihydrofolate reductase Not Available 0.0031
2931 Dihydrofolate reductase folA 0.0031
3544 Dihydrofolate reductase folA 0.0031
3682 Dihydrofolate reductase folA 0.0031
6642 Dihydrofolate reductase folA 0.0031
6756 Dihydrofolate reductase dfrA 0.0031
1864 RET proto-oncogene RET 0.0031
1629 Transcription factor AP-1 JUN 0.0031
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0031
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0031
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
70 Type-1 angiotensin II receptor AGTR1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
705 Glutamate receptor 1 GRIA1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6102 Arylamine N-acetyltransferase 2 NAT2 0.003
4203 Histamine N-methyltransferase HNMT 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
1024 Solute carrier family 22 member 11 SLC22A11 0.0029
1178 Adenosine A2a receptor ADORA2A 0.0029
1374 Natriuretic peptides B NPPB 0.0029
1827 Gap junction alpha-1 protein GJA1 0.0029
1908 Vascular cell adhesion protein 1 VCAM1 0.0029
6137 Multidrug resistance-associated protein 6 ABCC6 0.0029
756 Sex hormone-binding globulin SHBG 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
737 Mineralocorticoid receptor NR3C2 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
284 DNA-directed RNA polymerase beta chain rpoB 0.0029
5773 DNA-directed RNA polymerase beta chain rpoB 0.0029
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
26 Vascular endothelial growth factor receptor 3 FLT4 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
751 Potassium channel subfamily K member 6 KCNK6 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0026
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0026
1010 Cytochrome P450 51A1 CYP51A1 0.0026
32 Vascular endothelial growth factor receptor 1 FLT1 0.0026
49 Endothelin B receptor EDNRB 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0025
869 Estrogen receptor beta ESR2 0.0025
172 Potassium channel subfamily K member 1 KCNK1 0.0025
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0025
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0024
174 Sigma 1-type opioid receptor SIGMAR1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0022
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
4122 Histone deacetylase 2 HDAC2 0.0022
581 Cytochrome P450 2R1 CYP2R1 0.0022
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0022
3404 Exotoxin A eta 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0022
298 Renin REN 0.0021
16 Adenosine A1 receptor ADORA1 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6136 Multidrug resistance-associated protein 5 ABCC5 0.0021
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.002
6126 Carbonic anhydrase 7 CA7 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
482 Glycine receptor subunit alpha-1 GLRA1 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
165 FL cytokine receptor FLT3 0.0017
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0017
4311 tRNA TRDMT1 0.0017
4325 tRNA trmD 0.0017
4328 tRNA trmD 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
904 Glutathione S-transferase P GSTP1 0.0017
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0017
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0017
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0017
518 Peroxidase/catalase T katG 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4773 Deoxycytidine kinase DCK 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
3233 Bile acid receptor NR1H4 0.0015
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0015
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
563 Thyroid peroxidase TPO 0.0015
427 Substance-P receptor TACR1 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
275 Arachidonate 5-lipoxygenase ALOX5 0.0015
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0015
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0015
6824 Tyrosine-protein kinase Lyn LYN 0.0014
1541 Metalloproteinase mmp20 0.0014
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1341 Histamine H3 receptor HRH3 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
1192 Sulfotransferase 1A1 SULT1A1 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
153 Dopamine beta-hydroxylase DBH 0.0013
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
239 Coagulation factor X F10 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
921 Glutamate receptor 2 GRIA2 0.0011
1992 Vitamin D-binding protein GC 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
7 Nitric oxide synthase, inducible NOS2 0.0011
319 Opioid receptor, sigma 1 OPRS1 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
54 Prothrombin F2 0.001
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
4103 Proteasome subunit beta type 2 PSMB2 0.001
4102 Proteasome subunit beta type 5 PSMB5 0.001
4101 Proteasome subunit beta type 1 PSMB1 0.001
976 Platelet glycoprotein IX GP9 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1630 Integrin beta-2 ITGB2 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
3937 Fatty-acid amide hydrolase FAAH 0.001
4116 Dihydropteroate synthetase Not Available 0.001
469 Annexin A1 ANXA1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
511 5-hydroxytryptamine 1F receptor HTR1F 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
6146 High affinity copper uptake protein 1 SLC31A1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
823 Fibroblast growth factor receptor 2 FGFR2 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
6044 Serum paraoxonase/lactonase 3 PON3 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
1867 Major prion protein PRNP 0.0008
572 Integrin alpha-L ITGAL 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
1275 Estrogen sulfotransferase SULT1E1 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
5934 Cytochrome P450 26A1 CYP26A1 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
2298 Cytochrome P450-cam camC 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
3809 Estrogen-related receptor gamma ESRRG 0.0006
273 Apoptosis regulator Bcl-2 BCL2 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
6085 Fatty acid-binding protein, intestinal FABP2 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
3957 Adenosine deaminase ADA 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0005
2207 Rhodopsin RHO 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
517 Alcohol dehydrogenase 1C ADH1C 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
908 Glutathione S-transferase theta-1 GSTT1 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
162 Retinoic acid receptor gamma-1 RARG 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
2981 Phospholipase A2, membrane associated PLA2G2A 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0001
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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