DT-Web: DB01151

Identification

Name

Desipramine

Accession Number

DB01151 (APRD00022, DB07682)

Type

small molecule

Description

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

266.3807

Groups

approved

Monoisotopic Weight

266.178298714

Pharmacology

Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management.

Mechanism of action

Desipramine is a tricyclic antidepressant (TCA) that selectively blocks reuptake of norepinephrine (noradrenaline) from the neuronal synapse. It also inhibits serotonin reuptake, but to a lesser extent compared to tertiary amine TCAs such as imipramine. Inhibition of neurotransmitter reuptake increases stimulation of the post-synaptic neuron. Chronic use of desipramine also leads to down-regulation of beta-adrenergic receptors in the cerebral cortex and sensitization of serotonergic receptors. An overall increase in serotonergic transmission likely confers desipramine its antidepressant effects. Desipramine also possesses minor anticholinergic activity, through its affinity for muscarinic receptors. TCAs are believed to act by restoring normal levels of neurotransmitters via synaptic reuptake inhibition and by increasing serotonergic neurotransmission via serotonergic receptor sensitization in the central nervous system.

Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. It undergoes extensive first-pass metabolism. Peak plasma concentrations are attained 4 - 6 hours following oral administration.

Protein binding

73-92% bound to plasma proteins

Biotransformation

Desipramine is extensively metabolized in the liver by CYP2D6 (major) and CYP1A2 (minor) to 2-hydroxydesipramine, an active metabolite. 2-hydroxydesipramine is thought to retain some amine reuptake inhibition and may possess cardiac depressant activity. The 2-hydroxylation metabolic pathway of desipramine is under genetic control.

Route of elimination

Desipramine is metabolized in the liver, and approximately 70% is excreted in the urine.

Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg. Antagonism of the histamine H₁ and α₁ receptors can lead to sedation and hypotension. Antimuscarinic activity confers anticholinergic side effects such as blurred vision, dry mouth, constipation and urine retention may occur. Cardiotoxicity may occur with high doses of desipramine. Cardiovascular side effects in postural hypotension, tachycardia, hypertension, ECG changes and congestive heart failure. Psychotoxic effects include impaired memory and delirium. Induction of hypomanic or manic episodes may occur in patients with a history of bipolar disorder. Withdrawal symptoms include GI disturbances (e.g. nausea, vomiting, abdominal pain, diarrhea), anxiety, insomnia, nervousness, headache and malaise.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Altretamine	Risk of severe hypotension
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir	Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if atazanavir is initiated, discontinued or dose changed.
Avanafil	Co-administration with avanafil resulted in an approximate 5.7% increase in AUC0-inf and 5.2% decrease in Cmax of rosiglitazone.
Butabarbital	Barbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like desipramine. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Butalbital	Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants such as desipramine. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Carbamazepine	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, desipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if carbamazepine is initiated, discontinued or dose changed.
Cimetidine	Cimetidine may increase the effect of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if cimetidine is initiated, discontinued or dose changed.
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Clonidine	The tricyclic antidepressant, desipramine, decreases the effect of clonidine.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroquinidine barbiturate	Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, desipramine.
Dobutamine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of dobutamine.
Donepezil	Possible antagonism of action
Dopamine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of dopamine.
Duloxetine	Possible increase in the levels of this agent when used with duloxetine
Ephedra	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of ephedra.
Ephedrine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of ephedrine.
Epinephrine	Trimipramine may increase the vasopressor effect of the direct-acting alpha-/beta-agonist, Epinephrine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
Fenoterol	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of fenoterol.
Fluoxetine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of desipramine if fluoxetine is initiated, discontinued or dose changed.
Fluvoxamine	The SSRI, fluvoxamine, may increase the serum concentration of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of desipramine if fluvoxamine is initiated, discontinued or dose changed.
Galantamine	Possible antagonism of action
Grepafloxacin	Increased risk of cardiotoxicity and arrhythmias
Guanethidine	The tricyclic antidepressant, desipramine, decreases the effect of guanethidine.
Indacaterol	Concomitant therapy with monoamine oxidase inhibitors, tricyclic antidepressants, or other drugs that prolong the QTc interval should be monitored closely. These drugs may potentiate the effect of adrenergic agonist on the cardiovascular system.
Isocarboxazid	Possibility of severe adverse effects
Isoproterenol	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of isoproterenol.
Mephentermine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of mephentermine.
Metaraminol	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of metaraminol.
Methoxamine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of methoxamine.
Mirabegron	Mirabegron is a moderate CYP2D6 inhibitor and may cause an increase in exposure of CYP2D6 substrates. Monitor concomitant therapy closely.
Moclobemide	Possible severe adverse reaction with this combination
Norepinephrine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of norepinephrine.
Orciprenaline	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of orciprenaline.
Phenelzine	Possibility of severe adverse effects
Phenylephrine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of phenylephrine.
Phenylpropanolamine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of phenylpropanolamine.
Pirbuterol	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of pirbuterol.
Procaterol	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of procaterol.
Pseudoephedrine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of pseudoephedrine.
Quinidine	Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Quinidine barbiturate	Quinidine barbiturate increases the effect of tricyclic antidepressant, desipramine.
Rasagiline	Possibility of severe adverse effects
Rifabutin	The rifamycin, rifabutin, may decrease the effect of the tricyclic antidepressant, desipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if rifabutin is initiated, discontinued or dose changed.
Rifampin	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, desipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if rifampin is initiated, discontinued or dose changed.
Ritonavir	Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if ritonavir if initiated, discontinued or dose changed.
Rivastigmine	Possible antagonism of action
Salbutamol	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of salbutamol.
Sibutramine	Increased risk of CNS adverse effects
Sparfloxacin	Increased risk of cardiotoxicity and arrhythmias
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Desipramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tamoxifen	Desipramine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Desipramine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Desipramine is initiated, discontinued, or dose changed.
Terbinafine	Terbinafine may increase the effect and toxicity of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of desipramine if terbinafine is initiated, discontinued or dose changed.
Terbutaline	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of terbutaline.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tipranavir	Tipranavir, co-administered with Ritonavir, may increase the concentration of Desipramine. Monitor Desipramine concentration and efficacy/toxicity and adjust dose as required.
Tolterodine	Desipramine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	Tramadol increases the risk of serotonin syndrome and seizures. Desipramine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Desipramine may decrease the effect of Tramadol by decreasing active metabolite production.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome. Additive QTc-prolongation may also occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine	Triprolidine and Desipramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Desipramine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Vilazodone	Monitor for toxic effects of tricyclic antidepressants if a selective serotonin reuptake inhibitor (SSRI) is initiated or the dose is increased. The influence of the SSRI may take several days or weeks to be fully realized or resolved.
Voriconazole	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and desipramine, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Take with food to reduce irritation, limit caffeine intake.
Avoid alcohol.

Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Zavosh A, Schaefer J, Ferrel A, Figlewicz DP: Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells. Brain Res Bull. 1999 Jul 1;49(4):291-5. - Pubmed Weinshenker D, White SS, Javors MA, Palmiter RD, Szot P: Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo. Brain Res. 2002 Aug 16;946(2):239-46. - Pubmed Bryan-Lluka LJ, Bonisch H, Lewis RJ: chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter. J Biol Chem. 2003 Oct 10;278(41):40324-9. Epub 2003 Jul 1. - Pubmed Zhu MY, Kyle PB, Hume AS, Ordway GA: The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function. Neurochem Res. 2004 Feb;29(2):419-27. - Pubmed Ordway GA, Jia W, Li J, Zhu MY, Mandela P, Pan J: Norepinephrine transporter function and desipramine: residual drug effects versus short-term regulation. J Neurosci Methods. 2005 Apr 30;143(2):217-25. Epub 2004 Dec 30. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score	0.7258
Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Holmes A, Yang RJ, Murphy DL, Crawley JN: Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology. 2002 Dec;27(6):914-23. - Pubmed Gould GG, Altamirano AV, Javors MA, Frazer A: A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol Psychiatry. 2006 Mar 1;59(5):408-14. Epub 2005 Sep 2. - Pubmed Zhou L, Huang KX, Kecojevic A, Welsh AM, Koliatsos VE: Evidence that serotonin reuptake modulators increase the density of serotonin innervation in the forebrain. J Neurochem. 2006 Jan;96(2):396-406. Epub 2005 Nov 21. - Pubmed Hoffman AF, Gerhardt GA: In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions. J Neurochem. 1998 Jan;70(1):179-89. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score	0.5884
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.4864
Beta-2 adrenergic receptor
Name	Beta-2 adrenergic receptor
Gene Name	ADRB2
Pharmacological action	unknown
Actions	antagonist
References	Matsumoto K, Ojima K, Ohta H, Watanabe H: Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice. Pharmacol Biochem Behav. 1994 Sep;49(1):13-8. - Pubmed Sapena R, Morin D, Zini R, Morin C, Tillement JP: Desipramine treatment differently down-regulates beta-adrenoceptors of freshly isolated neurons and astrocytes. Eur J Pharmacol. 1996 Apr 4;300(1-2):159-62. - Pubmed Abadie C, Foucart S, Page P, Nadeau R: Modulation of noradrenaline release from isolated human atrial appendages. J Auton Nerv Syst. 1996 Dec 14;61(3):269-76. - Pubmed Prenner L, Sieben A, Zeller K, Weiser D, Haberlein H: Reduction of high-affinity beta2-adrenergic receptor binding by hyperforin and hyperoside on rat C6 glioblastoma cells measured by fluorescence correlation spectroscopy. Biochemistry. 2007 May 1;46(17):5106-13. Epub 2007 Apr 7. - Pubmed Osadchii OE, Woodiwiss AJ, Deftereos D, Norton GR: Temporal changes in myocardial adrenergic regulation with the progression to pump dysfunction after chronic beta-adrenoreceptor activation in rats. Pflugers Arch. 2007 Nov;455(2):251-60. Epub 2007 Jun 9. - Pubmed
DTHybrid score	0.8518
Beta-1 adrenergic receptor
Name	Beta-1 adrenergic receptor
Gene Name	ADRB1
Pharmacological action	unknown
Actions	other
References	Sapena R, Morin D, Zini R, Morin C, Tillement JP: Desipramine treatment differently down-regulates beta-adrenoceptors of freshly isolated neurons and astrocytes. Eur J Pharmacol. 1996 Apr 4;300(1-2):159-62. - Pubmed Burgi S, Baltensperger K, Honegger UE: Antidepressant-induced switch of beta 1-adrenoceptor trafficking as a mechanism for drug action. J Biol Chem. 2003 Jan 10;278(2):1044-52. Epub 2002 Oct 21. - Pubmed Matsumoto K, Ojima K, Ohta H, Watanabe H: Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice. Pharmacol Biochem Behav. 1994 Sep;49(1):13-8. - Pubmed Samnick S, Scheuer C, Munks S, El-Gibaly AM, Menger MD, Kirsch CM: Technetium-99m labeled 1-(4-fluorobenzyl)-4-(2-mercapto-2-methyl-4-azapentyl)-4-(2-mercapto-2-met hylpropylamino)-piperidine and iodine-123 metaiodobenzylguanidine for studying cardiac adrenergic function: a comparison of the uptake characteristics in vascular smooth muscle cells and neonatal cardiac myocytes, and an investigation in rats. Nucl Med Biol. 2004 May;31(4):511-22. - Pubmed Mudunkotuwa NT, Horton RW: Desipramine administration in the olfactory bulbectomized rat: changes in brain beta-adrenoceptor and 5-HT2A binding sites and their relationship to behaviour. Br J Pharmacol. 1996 Apr;117(7):1481-6. - Pubmed
DTHybrid score	0.8305
Sphingomyelin phosphodiesterase
Name	Sphingomyelin phosphodiesterase
Gene Name	SMPD1
Pharmacological action	unknown
Actions	inhibitor
References	Testai FD, Landek MA, Dawson G: Regulation of sphingomyelinases in cells of the oligodendrocyte lineage. J Neurosci Res. 2004 Jan 1;75(1):66-74. - Pubmed Kolzer M, Werth N, Sandhoff K: Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine. FEBS Lett. 2004 Feb 13;559(1-3):96-8. - Pubmed Erdreich-Epstein A, Tran LB, Cox OT, Huang EY, Laug WE, Shimada H, Millard M: Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways. Blood. 2005 Jun 1;105(11):4353-61. Epub 2005 Feb 10. - Pubmed Zeidan YH, Pettus BJ, Elojeimy S, Taha T, Obeid LM, Kawamori T, Norris JS, Hannun YA: Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem. 2006 Aug 25;281(34):24695-703. Epub 2006 Jun 27. - Pubmed Hurwitz R, Ferlinz K, Sandhoff K: The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts. Biol Chem Hoppe Seyler. 1994 Jul;375(7):447-50. - Pubmed Kornhuber J, Tripal P, Reichel M, Muhle C, Rhein C, Muehlbacher M, Groemer TW, Gulbins E: Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem. 2010;26(1):9-20. Epub 2010 May 18. - Pubmed
DTHybrid score	0.1201
Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	no
Actions	antagonist
References	Sawynok J, Esser MJ, Reid AR: Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. Pain. 1999 Aug;82(2):149-58. - Pubmed Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.8704
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.6726
Muscarinic acetylcholine receptor M1
Name	Muscarinic acetylcholine receptor M1
Gene Name	CHRM1
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.0866
Muscarinic acetylcholine receptor M2
Name	Muscarinic acetylcholine receptor M2
Gene Name	CHRM2
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9364
Muscarinic acetylcholine receptor M3
Name	Muscarinic acetylcholine receptor M3
Gene Name	CHRM3
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.9369
Muscarinic acetylcholine receptor M4
Name	Muscarinic acetylcholine receptor M4
Gene Name	CHRM4
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.6817
Muscarinic acetylcholine receptor M5
Name	Muscarinic acetylcholine receptor M5
Gene Name	CHRM5
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.5853
Transporter
Name	Transporter
Gene Name	snf
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.9876

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Lewis DF, Modi S, Dickins M: Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82. - Pubmed
DTHybrid score	1.2562
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7489
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3016
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8252
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.2318
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4535
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5552
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.505

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
DTHybrid score	0.8385
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed Grundemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H: Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 1994 Dec 8;372(6506):549-52. - Pubmed
DTHybrid score	0.5394
Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. - Pubmed Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed
DTHybrid score	0.4718
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Wu X, Huang W, Ganapathy ME, Wang H, Kekuda R, Conway SJ, Leibach FH, Ganapathy V: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. - Pubmed Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V: Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 1998 Jun 26;273(26):15971-9. - Pubmed Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score	0.3344
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score	0.446
Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Actions	inhibitor
References	Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):315-27. - Pubmed
DTHybrid score	0.348

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.8385
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions
References	Not Available
DTHybrid score	0.5394
Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions
References	Not Available
DTHybrid score	0.4718
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions
References	Not Available
DTHybrid score	0.3344
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions
References	Not Available
DTHybrid score	0.446
Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Actions
References	Not Available
DTHybrid score	0.348

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.6381
4924	Cytochrome P450 2C8	CYP2C8	0.4184
4118	Cytochrome P450 3A5	CYP3A5	0.3946
318	Alpha-2A adrenergic receptor	ADRA2A	0.3164
713	Sodium-dependent dopamine transporter	SLC6A3	0.3163
6107	Cytochrome P450 3A7	CYP3A7	0.3064
831	D(2) dopamine receptor	DRD2	0.302
6024	Cytochrome P450 1A1	CYP1A1	0.2757
632	Alpha-1B adrenergic receptor	ADRA1B	0.2752
320	5-hydroxytryptamine 1A receptor	HTR1A	0.255
590	5-hydroxytryptamine 2C receptor	HTR2C	0.2543
587	Serum albumin	ALB	0.2327
23	D(1A) dopamine receptor	DRD1	0.2278
789	Alpha-1D adrenergic receptor	ADRA1D	0.2152
3923	Cholinesterase	BCHE	0.187
629	Alpha-2B adrenergic receptor	ADRA2B	0.178
1517	Beta-3 adrenergic receptor	ADRB3	0.1723
378	Alpha-2C adrenergic receptor	ADRA2C	0.1723
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1651
3941	Amine oxidase [flavin-containing] A	MAOA	0.1417
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1287
1729	Solute carrier family 22 member 6	SLC22A6	0.128
638	D(3) dopamine receptor	DRD3	0.1227
436	5-hydroxytryptamine 2B receptor	HTR2B	0.1221
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.1214
432	D(4) dopamine receptor	DRD4	0.1202
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.1186
20	Prostaglandin G/H synthase 1	PTGS1	0.1175
131	Synaptic vesicular amine transporter	SLC18A2	0.116
6142	Solute carrier family 22 member 8	SLC22A8	0.1141
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1133
862	Multidrug resistance-associated protein 1	ABCC1	0.1125
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.1094
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1076
3939	Amine oxidase [flavin-containing] B	MAOB	0.1032
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0986
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0962
716	5-hydroxytryptamine 7 receptor	HTR7	0.084
465	Calmodulin	CALM1	0.0833
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0818
124	Histamine H2 receptor	HRH2	0.079
1898	Cytochrome P450 1B1	CYP1B1	0.0779
163	D(1B) dopamine receptor	DRD5	0.0748
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0747
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0747
3811	Cytochrome P450 19A1	CYP19A1	0.0747
776	Bile salt export pump	ABCB11	0.0725
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0719
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0714
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0679
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0637
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0636
474	Acetylcholinesterase	ACHE	0.0607
817	DNA topoisomerase 2-alpha	TOP2A	0.0569
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0549
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0547
696	Kappa-type opioid receptor	OPRK1	0.0546
847	Mu-type opioid receptor	OPRM1	0.0543
6143	Solute carrier family 22 member 7	SLC22A7	0.0541
477	DNA topoisomerase 4 subunit A	parC	0.054
886	DNA topoisomerase 4 subunit A	parC	0.054
6226	DNA topoisomerase 4 subunit A	parC	0.054
404	DNA gyrase subunit A	gyrA	0.0532
6224	DNA gyrase subunit A	gyrA	0.0532
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0532
467	Delta-type opioid receptor	OPRD1	0.0529
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0529
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0515
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0504
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0486
1656	CYP2B protein	CYP2B	0.0484
1024	Solute carrier family 22 member 11	SLC22A11	0.0483
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0481
2164	Multidrug resistance-associated protein 4	ABCC4	0.0481
290	Prostaglandin G/H synthase 2	PTGS2	0.0473
468	Cytochrome P450 4A11	CYP4A11	0.047
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.047
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0469
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0465
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0457
136	Estrogen receptor	ESR1	0.0452
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0447
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0434
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0424
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0424
1636	Trace amine-associated receptor 1	TAAR1	0.0423
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0408
731	HIV-1 protease	HIV-1 protease	0.0405
2300	Lysozyme	E	0.0404
3633	Lysozyme	R	0.0404
5597	Lysozyme	17	0.0404
260	Cytochrome P450 51	ERG11	0.0399
761	Cytochrome P450 51	ERG11	0.0399
3163	Cytochrome P450 51	cyp51	0.0399
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0394
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0392
828	Phenylalanine-4-hydroxylase	PAH	0.0389
3109	Phenylalanine-4-hydroxylase	phhA	0.0389
1757	Myeloperoxidase	MPO	0.0386
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0374
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0365
6014	Cytochrome P450 2A13	CYP2A13	0.0363
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.036
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0358
94	5-hydroxytryptamine 4 receptor	HTR4	0.0356
871	Glucocorticoid receptor	NR3C1	0.0356
380	Cytochrome P450 17A1	CYP17A1	0.0355
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0352
3947	Xanthine dehydrogenase/oxidase	XDH	0.035
3810	Catechol O-methyltransferase	COMT	0.0345
1341	Histamine H3 receptor	HRH3	0.034
6182	Cytochrome P450 2J2	CYP2J2	0.0339
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0339
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0338
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0338
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0336
2129	Sucrase-isomaltase, intestinal	SI	0.0331
6031	Cytochrome P450 3A43	CYP3A43	0.0323
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0321
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0321
6148	Multidrug resistance-associated protein 7	ABCC10	0.032
904	Glutathione S-transferase P	GSTP1	0.0318
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0311
844	Epidermal growth factor receptor	EGFR	0.031
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0307
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0305
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0304
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.03
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0293
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0292
174	Sigma 1-type opioid receptor	SIGMAR1	0.0291
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.029
164	Histamine H4 receptor	HRH4	0.0288
2472	Voltage-gated potassium channel	kcsA	0.0285
6366	Voltage-gated potassium channel	kcsA	0.0285
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0283
777	Tumor necrosis factor	TNF	0.0282
6136	Multidrug resistance-associated protein 5	ABCC5	0.0275
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0274
738	Monocarboxylate transporter 1	SLC16A1	0.0272
6137	Multidrug resistance-associated protein 6	ABCC6	0.0266
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0264
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0264
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0264
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0261
6141	Sodium/bile acid cotransporter	SLC10A1	0.0259
36	Insulin receptor	INSR	0.0258
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0258
161	Tubulin beta chain	TUBB	0.0252
312	Tubulin beta chain	TUB2	0.0252
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0251
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0249
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0249
4604	Liver carboxylesterase 1	CES1	0.0248
6010	Thiamine transporter 1	SLC19A2	0.0248
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0246
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0242
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0242
1618	High affinity nerve growth factor receptor	NTRK1	0.0241
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.024
482	Glycine receptor subunit alpha-1	GLRA1	0.0237
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0234
449	Ornithine decarboxylase	ODC1	0.0233
7	Nitric oxide synthase, inducible	NOS2	0.0229
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0225
624	Guanidinoacetate N-methyltransferase	GAMT	0.0225
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0225
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0224
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0223
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0223
5126	Arginase	rocF	0.0223
175	Thiamin pyrophosphokinase 1	TPK1	0.0222
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.022
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.022
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0218
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0218
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0218
723	Cytosolic phospholipase A2	PLA2G4A	0.0217
756	Sex hormone-binding globulin	SHBG	0.0216
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0211
4203	Histamine N-methyltransferase	HNMT	0.0211
3560	Gentamicin 3'-acetyltransferase	aacC1	0.021
122	P2Y purinoceptor 12	P2RY12	0.021
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0209
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0209
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0209
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0209
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0206
2429	Putrescine-binding periplasmic protein	potF	0.0206
869	Estrogen receptor beta	ESR2	0.0205
6102	Arylamine N-acetyltransferase 2	NAT2	0.0204
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0202
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0201
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0199
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0198
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0197
6070	Nischarin	NISCH	0.0196
4120	NADPH--cytochrome P450 reductase	POR	0.0195
146	Androgen receptor	AR	0.0194
6151	Monocarboxylate transporter 10	SLC16A10	0.0188
159	Penicillin-binding protein 2B	penA	0.0187
6121	Penicillin-binding protein 2B	penA	0.0187
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0187
1820	Beta-nerve growth factor	NGF	0.0186
6138	Multidrug resistance protein 3	ABCB4	0.0185
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0183
4773	Deoxycytidine kinase	DCK	0.0182
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0181
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0181
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0181
504	Mast/stem cell growth factor receptor	KIT	0.0179
614	Progesterone receptor	PGR	0.0178
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0174
150	Cationic amino acid transporter 3	SLC7A3	0.0173
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.0173
58	Cationic amino acid transporter 4	SLC7A4	0.0173
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0173
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0173
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0173
921	Glutamate receptor 2	GRIA2	0.0172
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0171
705	Glutamate receptor 1	GRIA1	0.017
516	Neurotensin receptor type 2	NTSR2	0.0168
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0165
6220	Aryl hydrocarbon receptor	AHR	0.0165
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0165
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0164
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0163
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0163
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0163
16	Adenosine A1 receptor	ADORA1	0.0162
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0162
976	Platelet glycoprotein IX	GP9	0.0162
5626	Nucleoside diphosphate kinase B	NME2	0.0162
183	Vascular endothelial growth factor A	VEGFA	0.0161
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0161
818	50S ribosomal protein L10	rplJ	0.016
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0159
3426	Glutamine synthetase	glnA	0.0159
3987	Glutamine synthetase	GLUL	0.0159
85	Growth hormone receptor	GHR	0.0156
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0156
737	Mineralocorticoid receptor	NR3C2	0.0156
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0151
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0151
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.015
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0148
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0147
1010	Cytochrome P450 51A1	CYP51A1	0.0147
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0147
1178	Adenosine A2a receptor	ADORA2A	0.0145
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0145
811	Translocator protein	TSPO	0.0145
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0144
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0143
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0143
891	Dihydropteroate synthase	folP	0.0143
5359	Dihydropteroate synthase	folP	0.0143
7175	Dihydropteroate synthase	sulI	0.0143
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0143
303	Diamine acetyltransferase 2	SAT2	0.0141
1317	Spermine synthase	SMS	0.0141
623	Spermine oxidase	SMOX	0.0141
29	Tubulin beta-1 chain	TUBB1	0.014
633	Penicillin-binding proteins 1A/1B	pbpA	0.0139
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0138
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0137
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0137
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0136
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0136
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0136
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0136
373	Transthyretin	TTR	0.0136
232	Corticosteroid-binding globulin	SERPINA6	0.0135
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0135
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0135
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0135
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0134
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0134
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0134
1192	Sulfotransferase 1A1	SULT1A1	0.0134
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0133
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0132
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0132
153	Dopamine beta-hydroxylase	DBH	0.0132
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0129
5294	Nucleoside diphosphate kinase A	NME1	0.0129
751	Potassium channel subfamily K member 6	KCNK6	0.0128
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0128
4237	50S ribosomal protein L22	rplV	0.0127
6146	High affinity copper uptake protein 1	SLC31A1	0.0127
123	Diamine acetyltransferase 1	SAT1	0.0127
1275	Estrogen sulfotransferase	SULT1E1	0.0126
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0125
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0125
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0125
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0125
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0125
769	High-affinity choline transporter 1	SLC5A7	0.0125
3927	Choline transporter-like protein 3	SLC44A3	0.0125
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0125
1686	Choline transporter-like protein 1	SLC44A1	0.0125
3926	Choline transporter-like protein 2	SLC44A2	0.0125
861	Choline kinase alpha	CHKA	0.0125
700	Choline dehydrogenase, mitochondrial	CHDH	0.0125
3925	Choline transporter-like protein 4	SLC44A4	0.0125
576	Choline O-acetyltransferase	CHAT	0.0125
3922	Phospholipase D2	PLD2	0.0125
3924	Phospholipase D1	PLD1	0.0125
5682	Ribonuclease pancreatic	RNASE1	0.0125
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0124
4292	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase	lpxA	0.0124
6174	50S ribosomal protein L32	rpmF	0.0124
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0123
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0123
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0123
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0122
3076	Antigen 85-C	fbpC	0.0122
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0122
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0118
908	Glutathione S-transferase theta-1	GSTT1	0.0118
2230	Catalase	CAT	0.0118
3249	Catalase	katA	0.0118
3625	Catalase	katA	0.0118
4539	Catalase	katA	0.0118
4941	Catalase	katB	0.0118
172	Potassium channel subfamily K member 1	KCNK1	0.0117
4238	50S ribosomal protein L4	rplD	0.0117
5578	50S ribosomal protein L4	rplD	0.0117
6173	50S ribosomal protein L4	rplD	0.0117
6219	50S ribosomal protein L4	rplD	0.0117
1374	Natriuretic peptides B	NPPB	0.0117
1827	Gap junction alpha-1 protein	GJA1	0.0117
1908	Vascular cell adhesion protein 1	VCAM1	0.0117
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
26	Vascular endothelial growth factor receptor 3	FLT4	0.0116
1050	Bile salt sulfotransferase	SULT2A1	0.0115
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0115
251	Alcohol dehydrogenase 1A	ADH1A	0.0115
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0115
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0114
444	Alcohol dehydrogenase 1B	ADH1B	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
221	Lysyl-tRNA synthetase	KARS	0.0112
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0111
32	Vascular endothelial growth factor receptor 1	FLT1	0.0111
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0108
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0108
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0107
6165	Copper-transporting ATPase 1	ATP7A	0.0107
6163	Copper-transporting ATPase 2	ATP7B	0.0107
407	Vascular endothelial growth factor receptor 2	KDR	0.0107
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
563	Thyroid peroxidase	TPO	0.0106
952	Dipeptidyl peptidase 4	DPP4	0.0106
3932	Glutathione S-transferase A2	GSTA2	0.0104
1353	DNA topoisomerase 1	TOP1	0.0103
3552	DNA topoisomerase 1	topA	0.0103
319	Opioid receptor, sigma 1	OPRS1	0.0102
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
2539	Tubulin alpha-1 chain	TUBA4A	0.0101
1830	5'-nucleotidase	NT5E	0.01
518	Peroxidase/catalase T	katG	0.01
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0099
4122	Histone deacetylase 2	HDAC2	0.0098
619	Low-affinity cationic amino acid transporter 2	SLC7A2	0.0098
694	Matrix protein 2	M	0.0098
84	Nuclear receptor 0B1	NR0B1	0.0098
2449	Tubulin alpha-3 chain	TUBA1A	0.0098
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0098
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0098
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
571	Melatonin receptor type 1A	MTNR1A	0.0096
362	Melatonin receptor type 1B	MTNR1B	0.0096
275	Arachidonate 5-lipoxygenase	ALOX5	0.0096
70	Type-1 angiotensin II receptor	AGTR1	0.0095
6020	Aldehyde oxidase	AOX1	0.0095
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0094
896	Glutathione S-transferase Mu 1	GSTM1	0.0094
6847	Lactase-phlorizin hydrolase	LCT	0.0093
291	Nitric-oxide synthase, endothelial	NOS3	0.0093
1176	Mitogen-activated protein kinase 1	MAPK1	0.0093
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0092
6168	Solute carrier family 22 member 16	SLC22A16	0.0092
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
517	Alcohol dehydrogenase 1C	ADH1C	0.0091
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0089
499	Arginine decarboxylase	ADC	0.0089
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0088
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0088
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0088
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0087
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0087
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0087
295	Carbonic anhydrase 1	CA1	0.0087
702	UMP-CMP kinase	CMPK1	0.0087
68	Cannabinoid receptor 1	CNR1	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
6085	Fatty acid-binding protein, intestinal	FABP2	0.0086
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
3937	Fatty-acid amide hydrolase	FAAH	0.0085
577	Argininosuccinate lyase	ASL	0.0085
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0085
768	FK506-binding protein 1A	FKBP1A	0.0085
834	Arginase-2, mitochondrial	ARG2	0.0084
5787	Angiopoietin-1 receptor	TEK	0.0083
1	Peptidoglycan synthetase ftsI	ftsI	0.0083
4155	Peptidoglycan synthetase ftsI	ftsI	0.0083
592	Carbonic anhydrase 4	CA4	0.0081
1864	RET proto-oncogene	RET	0.0081
125	DNA polymerase beta	POLB	0.0081
3808	Dihydropteroate synthase 2	folP2	0.0081
3601	Dihydropteroate synthase 1	folP1	0.0081
3807	Dihydropteroate synthase 1	folP1	0.0081
1629	Transcription factor AP-1	JUN	0.0081
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0081
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.008
565	Extracellular calcium-sensing receptor	CASR	0.008
427	Substance-P receptor	TACR1	0.008
3611	Cytidine deaminase	cdd	0.008
3707	Cytidine deaminase	cdd	0.008
4211	Cytidine deaminase	CDA	0.008
357	Carbonic anhydrase 2	CA2	0.008
645	Penicillin-binding protein 1A	mrcA	0.0079
5805	Penicillin-binding protein 1A	ponA	0.0079
6185	Penicillin-binding protein 1A	mrcA	0.0079
6799	Penicillin-binding protein 1A	pbpA	0.0079
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0079
6171	Solute carrier family 28 member 3	SLC28A3	0.0079
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0079
740	Argininosuccinate synthase	ASS1	0.0079
865	Argininosuccinate synthase	ASS1	0.0079
2680	Argininosuccinate synthase	argG	0.0079
3194	Argininosuccinate synthase	argG	0.0079
284	DNA-directed RNA polymerase beta chain	rpoB	0.0079
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0079
173	Toll-like receptor 7	TLR7	0.0079
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0079
1770	Phospholipase C	PLCL1	0.0079
2841	Phospholipase C	plc	0.0079
1039	Histone deacetylase 9	HDAC9	0.0078
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0078
365	Dihydrofolate reductase	DHFR	0.0078
2381	Dihydrofolate reductase	DFR1	0.0078
2833	Dihydrofolate reductase	Not Available	0.0078
2931	Dihydrofolate reductase	folA	0.0078
3544	Dihydrofolate reductase	folA	0.0078
3682	Dihydrofolate reductase	folA	0.0078
6642	Dihydrofolate reductase	folA	0.0078
6756	Dihydrofolate reductase	dfrA	0.0078
867	Penicillin-binding protein 3	pbpC	0.0077
6119	Penicillin-binding protein 3	pbp3	0.0077
7154	Penicillin-binding protein 3	pbp3	0.0077
7157	Penicillin-binding protein 3	LMHCC_2184	0.0077
7162	Penicillin-binding protein 3	pbpB	0.0077
7172	Penicillin-binding protein 3	pbp3	0.0077
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0077
244	Angiotensin-converting enzyme	ACE	0.0076
923	Glutamate receptor 3	GRIA3	0.0075
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0075
780	Retinoic acid receptor RXR-gamma	RXRG	0.0075
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0073
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0073
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0073
551	Carnitine O-acetyltransferase	CRAT	0.0073
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0072
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0071
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
1074	Urokinase-type plasminogen activator	PLAU	0.0071
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0069
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0069
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0068
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0068
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0068
88	Retinoic acid receptor RXR-beta	RXRB	0.0068
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0067
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0067
823	Fibroblast growth factor receptor 2	FGFR2	0.0067
6149	Solute carrier family 22 member 10	SLC22A10	0.0066
719	Retinoic acid receptor responder protein 1	RARRES1	0.0066
770	Retinoic acid-induced protein 3	GPRC5A	0.0066
6766	O-GlcNAcase BT_4395	BT_4395	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
233	Potassium channel subfamily K member 2	KCNK2	0.0065
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0065
814	Ryanodine receptor 1	RYR1	0.0065
860	Nicotinamide N-methyltransferase	NNMT	0.0064
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0064
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
699	Nicotinic acid receptor 1	GPR109A	0.0064
928	Nicotinic acid receptor 2	GPR109B	0.0064
2298	Cytochrome P450-cam	camC	0.0063
239	Coagulation factor X	F10	0.0063
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
6167	Organic solute transporter subunit beta	OSTB	0.0063
6166	Organic solute transporter subunit alpha	OSTA	0.0063
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0062
2112	Toll-like receptor 9	TLR9	0.0062
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0062
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0062
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0062
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0062
4217	Telomerase reverse transcriptase	TERT	0.0062
106	Cannabinoid receptor 2	CNR2	0.0061
6097	Protein S100-A2	S100A2	0.006
1810	Protein S100-A1	S100A1	0.006
6859	Protein S100-A4	S100A4	0.006
6218	Pannexin-1	PANX1	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0059
332	Beta-lactamase	blaZ	0.0059
2478	Beta-lactamase	ampC	0.0059
2613	Beta-lactamase	ampC	0.0059
2635	Beta-lactamase	ampC	0.0059
2700	Beta-lactamase	penP	0.0059
5445	Beta-lactamase	blaB	0.0059
6019	Beta-lactamase	SHV-7	0.0059
6701	Beta-lactamase	cphA	0.0059
3809	Estrogen-related receptor gamma	ESRRG	0.0059
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0059
273	Apoptosis regulator Bcl-2	BCL2	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
6126	Carbonic anhydrase 7	CA7	0.0058
6067	Penicillin binding protein 2a	mecA	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
162	Retinoic acid receptor gamma-1	RARG	0.0058
856	Vitamin D3 receptor	VDR	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
569	Retinal dehydrogenase 2	ALDH1A2	0.0057
788	Creatine kinase M-type	CKM	0.0057
4311	tRNA	TRDMT1	0.0055
4325	tRNA	trmD	0.0055
4328	tRNA	trmD	0.0055
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0055
6506	Stathmin-4	STMN4	0.0055
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0055
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0055
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0055
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0054
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0054
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0054
65	Matrix metalloproteinase-9	Not Available	0.0054
611	Retinal dehydrogenase 1	ALDH1A1	0.0054
4192	DNA topoisomerase 2-beta	TOP2B	0.0054
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0052
49	Endothelin B receptor	EDNRB	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0052
6211	Tubulin epsilon chain	TUBE1	0.0052
6212	Tubulin gamma-1 chain	TUBG1	0.0052
6210	Tubulin delta chain	TUBD1	0.0052
3090	Chitosanase	csn	0.0052
1048	Protein S100-A13	S100A13	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
2226	Protein S100-A12	S100A12	0.0052
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0051
469	Annexin A1	ANXA1	0.005
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
4103	Proteasome subunit beta type 2	PSMB2	0.005
4102	Proteasome subunit beta type 5	PSMB5	0.005
4101	Proteasome subunit beta type 1	PSMB1	0.005
578	Endothelin-1 receptor	EDNRA	0.0049
6043	Putative G-protein coupled receptor 44	GPR44	0.0049
3404	Exotoxin A	eta	0.0049
2132	Protein S100-B	S100B	0.0049
6044	Serum paraoxonase/lactonase 3	PON3	0.0049
165	FL cytokine receptor	FLT3	0.0049
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0048
2320	Thymidine kinase, cytosolic	TK1	0.0048
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0048
5300	Antigen peptide transporter 1	TAP1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1483	Membrane copper amine oxidase	AOC3	0.0046
581	Cytochrome P450 2R1	CYP2R1	0.0046
1253	Interferon gamma	IFNG	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
558	Solute carrier family 12 member 1	SLC12A1	0.0046
3957	Adenosine deaminase	ADA	0.0045
634	Squalene monooxygenase	SQLE	0.0045
7196	Squalene monooxygenase	ERG1	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0045
5934	Cytochrome P450 26A1	CYP26A1	0.0044
4116	Dihydropteroate synthetase	Not Available	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
117	Sterol O-acyltransferase 1	SOAT1	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
24	Thymidylate synthase	TMP1	0.0043
359	Thymidylate synthase	TYMS	0.0043
2626	Thymidylate synthase	thyA	0.0043
2729	Thymidylate synthase	thyA	0.0043
5352	Thymidylate synthase	THYA	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
489	Monocarboxylate transporter 2	SLC16A7	0.0042
1852	Microtubule-associated protein 2	MAP2	0.0042
33	Cystine/glutamate transporter	SLC7A11	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
400	Coagulation factor IX	F9	0.004
5461	Coagulation factor IX	F9	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
500	Monocarboxylate transporter 4	SLC16A3	0.004
1262	Corticotropin-lipotropin	POMC	0.004
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0039
3856	Fibroblast growth factor receptor 3	FGFR3	0.0039
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0039
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0039
1268	Neuropeptide S receptor	NPSR1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
820	Glycine receptor subunit alpha-2	GLRA2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1630	Integrin beta-2	ITGB2	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0037
992	Protein tyrosine kinase 2 beta	PTK2B	0.0037
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0037
604	Vitamin K-dependent protein Z	PROZ	0.0037
527	Prostacyclin receptor	PTGIR	0.0036
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0035
6073	Potassium channel subfamily K member 9	KCNK9	0.0035
6072	Potassium channel subfamily K member 3	KCNK3	0.0035
939	50S ribosomal protein L3	rplC	0.0035
54	Prothrombin	F2	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
1992	Vitamin D-binding protein	GC	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
1245	Vitamin K-dependent protein S	PROS1	0.0034
422	Vitamin K-dependent protein C	PROC	0.0034
936	Ephrin type-A receptor 2	EPHA2	0.0034
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0034
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
2207	Rhodopsin	RHO	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0031
6824	Tyrosine-protein kinase Lyn	LYN	0.0031
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0031
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.003
358	Cystathionine beta-synthase	CBS	0.003
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
3913	Glutamic acid decarboxylase	GAD65	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
798	Osteocalcin	BGLAP	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0027
4226	Uridine phosphorylase 2	UPP2	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0026
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
268	Adenosine A2b receptor	ADORA2B	0.0026
1648	Elastin	ELN	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0025
459	Retinoic acid receptor RXR-alpha	RXRA	0.0025
369	Coagulation factor VII	F7	0.0025
5798	Mitogen-activated protein kinase 11	MAPK11	0.0025
4225	Uridine phosphorylase 1	UPP1	0.0024
735	Alanine aminotransferase 1	GPT	0.0024
3904	Alanine aminotransferase 2	GPT2	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
413	Amidophosphoribosyltransferase	PPAT	0.0023
2515	Amidophosphoribosyltransferase	purF	0.0023
3714	Amidophosphoribosyltransferase	purF	0.0023
6131	Carbonic anhydrase 14	CA14	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
298	Renin	REN	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
2091	Endoplasmin	HSP90B1	0.0021
3221	Cytochrome c4	cc4	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.002
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.002
293	Gamma-glutamyl hydrolase	GGH	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0019
2236	Casein kinase II subunit alpha	CSNK2A1	0.0019
572	Integrin alpha-L	ITGAL	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0019
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
6459	Glycodelin	PAEP	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
1196	Complement decay-accelerating factor	CD55	0.0019
267	Plasminogen activator inhibitor 1	SERPINE1	0.0019
3587	Gastrotropin	FABP6	0.0019
3639	Thymidine phosphorylase	deoA	0.0019
3936	Thymidine phosphorylase	TYMP	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
5923	Microtubule-associated protein tau	MAPT	0.0018
5924	Microtubule-associated protein 4	MAP4	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0018
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0018
1650	Heme carrier protein 1	SLC46A1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
3830	Calreticulin	CALR	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
484	Tyrosine-protein kinase ABL2	ABL2	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
6221	Steroid hormone receptor ERR1	ESRRA	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0017
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0017
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
2808	Chloramphenicol acetyltransferase 3	cat3	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
2216	Fibroblast growth factor receptor 4	FGFR4	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
76	Nitric-oxide synthase, brain	NOS1	0.0016
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0016
1243	Cathepsin D	CTSD	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0015
3233	Bile acid receptor	NR1H4	0.0015
2408	Tyrosine-protein kinase SYK	SYK	0.0015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0015
6755	Poliovirus receptor	PVR	0.0015
2417	Chloramphenicol acetyltransferase	cat	0.0015
3278	Chloramphenicol acetyltransferase	cat	0.0015
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0015
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0015
2810	Dr hemagglutinin structural subunit	draA	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1541	Metalloproteinase	mmp20	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
4954	Soluble cytochrome b558	Not Available	0.0014
4925	Cytochrome c-type protein SHP	shp	0.0014
4934	Cytochrome c-551	nirM	0.0014
5218	Cytochrome c-551	nirM	0.0014
4905	Cytochrome c2	Not Available	0.0014
4939	Cytochrome c2	cycA	0.0014
4964	Cytochrome c2	cycA	0.0014
4979	Cytochrome c2	cycA	0.0014
6673	Cytochrome c2	cycA	0.0014
4915	Cytochrome c-550	psbV	0.0014
4959	Cytochrome c-550	psbV	0.0014
5216	Cytochrome c-550	psbV	0.0014
4947	Bacterial hemoglobin	vhb	0.0014
4984	Neuroglobin	NGB	0.0014
4998	Hemoglobin-like protein yjbI	yjbI	0.0014
4975	Cytochrome c-556	RPA3973	0.0014
4943	Cytochrome c6	petJ	0.0014
4916	Cyanoglobin	glbN	0.0014
4994	Hemoglobin-like protein HbO	glbO	0.0014
4907	Cytochrome c-L	moxG	0.0014
6865	Cytochrome c-L	moxG	0.0014
4936	Cytochrome c2 iso-2	Not Available	0.0014
4909	CooA protein	cooA	0.0014
644	Heme oxygenase 2	HMOX2	0.0014
4982	Heme oxygenase 2	pbsA2	0.0014
4942	Diheme cytochrome c napB	napB	0.0014
4910	Cytoglobin	CYGB	0.0014
4981	Iron-starvation protein PigA	pigA	0.0014
4935	Cytochrome c-554	cycA1	0.0014
4971	Nonaheme cytochrome c	hmcA	0.0014
4961	Hemophore HasA	hasA	0.0014
4904	Cytochrome c family protein	GSU1996	0.0014
4976	Apocytochrome f	petA	0.0014
6407	Apocytochrome f	petA	0.0014
5000	HemO	hemO	0.0014
4989	Cytochrome c551 peroxidase	ccp	0.0014
5222	Cytochrome c551 peroxidase	ccpA	0.0014
4960	Putative cytochrome P450-family protein	SCO7417	0.0014
4931	Cytochrome P450 167A1	CYP167A1	0.0014
4764	Cytochrome P450 165C4	CYP165C4	0.0014
4999	Cytochrome P450 165B3	CYP165B3	0.0014
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0014
4972	P450cin	cinA	0.0014
4903	Methyl-accepting chemotaxis protein	Tar4	0.0014
4993	Hydroxylamine oxidoreductase	hao1	0.0014
4937	Cytochrome oxidase subunit II	rcoxA	0.0014
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0014
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0014
3093	Catalase HPII	katE	0.0014
4922	Cytochrome c, putative	SO_4144	0.0014
4952	Catalase/peroxidase	katA	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
2021	Thrombomodulin	THBD	0.0012
1295	Fatty acid synthase	FASN	0.0012
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2802	Endoglucanase G	celCCG	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4920	Peroxidase/catalase	katG	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
2119	Cytochrome b5	CYB5A	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.001
4990	PpcA	ppcA	0.001
3375	Acidic cytochrome c3	Not Available	0.001
4988	Sulfite oxidase, mitochondrial	SUOX	0.001
4385	Cytochrome c'	Not Available	0.001
4967	Cytochrome c'	cycA	0.001
5038	Cytochrome c'	Not Available	0.001
5223	Cytochrome c'	cycP	0.001
2915	Sensor protein fixL	fixL	0.001
4944	Sensor protein fixL	fixL	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
3570	Cytochrome P450 152A1	cypC	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
4992	Cytochrome c peroxidase	Not Available	0.001
4813	Heme oxygenase	hmuO	0.001
5769	Heme oxygenase	Not Available	0.001
4289	Cytochrome P450	TT_P0059	0.001
6262	Cytochrome P450	staP	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
6042	Prostaglandin reductase 2	PTGR2	0.0009
3670	Soluble cytochrome b562 precursor	cybC	0.0009
3411	Cytochrome P450 121	cyp121	0.0009
3291	Cytochrome c-552	cycA	0.0009
4927	Cytochrome c-552	nrfA	0.0009
4938	Cytochrome c-552	cycA	0.0009
4953	Cytochrome c-552	nrfA	0.0009
5217	Cytochrome c-552	cycM	0.0009
2617	Nitric oxide synthase oxygenase	nos	0.0009
2701	Nitric oxide synthase oxygenase	nos	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
3102	Flavohemoprotein	hmp	0.0008
4969	Flavohemoprotein	hmp	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
1792	Tissue-type plasminogen activator	PLAT	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
1867	Major prion protein	PRNP	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
3127	Nitrite reductase	nirS	0.0008
3284	Nitrite reductase	nirS	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0008
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
4608	Putative cytochrome P450	SCO1207	0.0007
4963	Putative cytochrome P450	SCO2884	0.0007
6254	Putative cytochrome P450	SCO6998	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
822	Aldose reductase	AKR1B1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1313	Lactoylglutathione lyase	GLO1	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
1507	Cytochrome c	CYCS	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
693	Hemoglobin subunit beta	HBB	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6268	Hydroxyacid oxidase 1	HAO1	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
810	Heme oxygenase 1	HMOX1	0.0006
3391	Heme oxygenase 1	pbsA1	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01151 - Desipramine

Targets

Enzymes

Transporters

Carriers

Predictions