DT-Web

DB01036 - Tolterodine


Identification
Name Tolterodine
Accession Number DB01036 (APRD00146)
Type small molecule
Description Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 325.4876
Groups approved
Monoisotopic Weight 325.240564619
Pharmacology
Indication For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
Mechanism of action Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, act as competitive antagonists at muscarinic receptors. This antagonism results in inhibition of bladder contraction, decrease in detrusor pressure, and an incomplete emptying of the bladder.
Absorption Not Available
Protein binding Approximately 96.3%.
Biotransformation Not Available
Route of elimination Following administration of a 5-mg oral dose of 14C-tolterodine solution to healthy volunteers, 77% of radioactivity was recovered in urine and 17% was recovered in feces in 7 days.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiodarone Amiodarone may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Amprenavir Amprenavir may decrease the metabolism and clearance of Tolterodine. Adjust the Tolterodine dose and monitor for efficacy and toxicity.
Aprepitant Aprepitant may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Atazanavir Atazanavir may decrease the metabolism and clearance of Tolterodine. Adjust the Tolterodine dose and monitor for efficacy and toxicity.
Caffeine Caffeine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Chlorpromazine Chlorpromazine may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Cimetidine Cimetidine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Cinacalcet Cinacalcet may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Clarithromycin Clarithromycin may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Clotrimazole Clotrimazole may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Cocaine Cocaine may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Conivaptan Conivaptan may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Cyclosporine Cyclosporine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Darunavir Darunavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Delavirdine Delavirdine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Desipramine Desipramine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Diltiazem Diltiazem may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Donepezil Possible antagonism of action
Doxycycline Doxycycline may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Efavirenz Efavirenz may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Etravirine Etravirene may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Fluconazole Fluconazole may decrease the metabolism and clearance of tolterodine. Adjust tolterodine dose and monitor for efficacy and toxicity.
Fluoxetine Fluoxetine may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Fosamprenavir Fosamprenavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Galantamine Possible antagonism of action
Haloperidol Haloperidol may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Imatinib Imatinib may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Indinavir Indinavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Isoniazid Isoniazid may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Itraconazole Itraconazole may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Ketoconazole Ketoconazole may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Lapatinib Lapatinib may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Lidocaine Lidocaine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Lopinavir Lopinavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Metronidazole Metronidazole may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Miconazole Miconazole may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Nefazodone Nefazodone may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Nelfinavir Nelfinavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Nicardipine Nicardipine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Norfloxacin Norfloxacin may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Paroxetine Paroxetine may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Pergolide Peroglide may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Posaconazole Posaconazole may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Potassium Chloride The ulcerative effects of solid oral dosage forms of KCl may be enhanced by the anticholinergic, Tolterodine. Anticholinergics slow gastric emptying, increasing the contact time between the gastrointestinal mucosa and KCl. Prolonged exposure to KCl increases the risk of gastric and intestinal irritation and ulceration. Solid oral dosage forms of KCl should be avoided; alternatives include liquid or effervescent potassium preparations.
Pramlintide Additive reduction in gut motility may occur. Consider alternate therapy or use caution during concomitant therapy.
Quinidine Quinidine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Ranolazine Ranolazine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Ritonavir Ritonavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Saquinavir Saquinavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Secretin The stimulatory effect of Secretin may be reduced by anticholinergics such as Tolterodine. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be used, Secretin efficacy should be closely monitored.
Sertraline Sertraline may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Sitaxentan Sitaxsentan may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Tolterodine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Telithromycin Telithromycin may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Terbinafine Terbinafine may reduce the metabolism and clearance of Tolterodine. Consider alternate therapy or monitor for therapeutic/adverse effects of Tolterodine if Terbinafine is initiated, discontinued or dose changed.
Tetracycline Tetracycline may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Trimethobenzamide Trimethobenzamide and Tolterodine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine Triprolidine and Tolterodine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trospium Trospium and Tolterodine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Verapamil Verapamil may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Vinblastine Vinblastine, a CYP3A4 inhibitor, may increase the serum concentration of Tolterodine by decreasing its metabolism. Poor CYP2D6 metabolizers metabolize Tolterodine via CYP3A4. A dose adjustment of Tolterodine may be required. Monitor for changes in the therapeutic/adverse effects of Tolterodine if Vinblastine is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of tolterodine by decreasing its metabolism. Tolterodine is mainly metabolized via the CYP2D6 pathway. This interaction is likely only a concern in patients who are poor CYP2D6 metabolizers. Monitor for changes in the therapeutic and adverse effects of tolterodine if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.

Targets


Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Schneider T, Fetscher C, Krege S, Michel MC: Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53. Epub 2004 Feb 9. - Pubmed
  • McNamara A, Pulido-Rios MT, Sweazey S, Obedencio GP, Thibodeaux H, Renner T, Armstrong SR, Steinfeld T, Hughes AD, Wilson RD, Jasper JR, Mammen M, Hegde SS: Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist. Eur J Pharmacol. 2009 Mar 1;605(1-3):145-52. Epub 2009 Jan 10. - Pubmed
  • Sellers DJ, Yamanishi T, Chapple CR, Couldwell C, Yasuda K, Chess-Williams R: M3 muscarinic receptors but not M2 mediate contraction of the porcine detrusor muscle in vitro. J Auton Pharmacol. 2000 Jun;20(3):171-6. - Pubmed
DTHybrid score 0.7822
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action yes
Actions antagonist
References
  • Nelson CP, Nahorski SR, Challiss RA: Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor. J Pharmacol Exp Ther. 2006 Jan;316(1):279-88. Epub 2005 Sep 27. - Pubmed
  • Schneider T, Fetscher C, Krege S, Michel MC: Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53. Epub 2004 Feb 9. - Pubmed
  • McNamara A, Pulido-Rios MT, Sweazey S, Obedencio GP, Thibodeaux H, Renner T, Armstrong SR, Steinfeld T, Hughes AD, Wilson RD, Jasper JR, Mammen M, Hegde SS: Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist. Eur J Pharmacol. 2009 Mar 1;605(1-3):145-52. Epub 2009 Jan 10. - Pubmed
  • Sellers DJ, Yamanishi T, Chapple CR, Couldwell C, Yasuda K, Chess-Williams R: M3 muscarinic receptors but not M2 mediate contraction of the porcine detrusor muscle in vitro. J Auton Pharmacol. 2000 Jun;20(3):171-6. - Pubmed
DTHybrid score 0.7757
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action yes
Actions antagonist
References
  • Maruyama S, Oki T, Otsuka A, Shinbo H, Ozono S, Kageyama S, Mikami Y, Araki I, Takeda M, Masuyama K, Yamada S: Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder. J Urol. 2006 Jan;175(1):365-9. - Pubmed
DTHybrid score 0.4568
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Schneider T, Fetscher C, Krege S, Michel MC: Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53. Epub 2004 Feb 9. - Pubmed
DTHybrid score 0.8948
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action yes
Actions antagonist
References
  • Maruyama S, Oki T, Otsuka A, Shinbo H, Ozono S, Kageyama S, Mikami Y, Araki I, Takeda M, Masuyama K, Yamada S: Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder. J Urol. 2006 Jan;175(1):365-9. - Pubmed
DTHybrid score 0.5566

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Postlind H, DanielsonA, Lindgren A, Andersson SH: Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes. Drug Metab Dispos. 1998 Apr;26(4):289-93. - Pubmed
DTHybrid score 0.5727
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5097
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4152
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3749

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.2299
1588 Multidrug resistance protein 1 ABCB1 0.2281
492 Histamine H1 receptor HRH1 0.2024
4924 Cytochrome P450 2C8 CYP2C8 0.2022
4118 Cytochrome P450 3A5 CYP3A5 0.1669
6030 Cytochrome P450 2B6 CYP2B6 0.1559
6013 Cytochrome P450 2E1 CYP2E1 0.1457
502 5-hydroxytryptamine 2A receptor HTR2A 0.1348
556 Alpha-1A adrenergic receptor ADRA1A 0.1183
6107 Cytochrome P450 3A7 CYP3A7 0.1153
831 D(2) dopamine receptor DRD2 0.1086
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0934
824 Sodium-dependent serotonin transporter SLC6A4 0.0926
590 5-hydroxytryptamine 2C receptor HTR2C 0.0924
3923 Cholinesterase BCHE 0.0908
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0847
5718 Cytochrome P450 2A6 CYP2A6 0.0829
23 D(1A) dopamine receptor DRD1 0.0824
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.081
6024 Cytochrome P450 1A1 CYP1A1 0.0764
632 Alpha-1B adrenergic receptor ADRA1B 0.0726
587 Serum albumin ALB 0.0714
20 Prostaglandin G/H synthase 1 PTGS1 0.0713
789 Alpha-1D adrenergic receptor ADRA1D 0.0679
320 5-hydroxytryptamine 1A receptor HTR1A 0.0616
432 D(4) dopamine receptor DRD4 0.057
318 Alpha-2A adrenergic receptor ADRA2A 0.0566
638 D(3) dopamine receptor DRD3 0.0522
6145 Solute carrier family 22 member 1 SLC22A1 0.051
6106 Cytochrome P450 2C18 CYP2C18 0.0505
341 5-hydroxytryptamine 3 receptor HTR3A 0.0487
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.048
6144 Solute carrier family 22 member 2 SLC22A2 0.0471
629 Alpha-2B adrenergic receptor ADRA2B 0.044
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0428
378 Alpha-2C adrenergic receptor ADRA2C 0.0422
118 Organic cation/carnitine transporter 2 SLC22A5 0.0395
833 Organic cation/carnitine transporter 1 SLC22A4 0.0389
713 Sodium-dependent dopamine transporter SLC6A3 0.0388
766 Beta-2 adrenergic receptor ADRB2 0.036
436 5-hydroxytryptamine 2B receptor HTR2B 0.0356
885 5-hydroxytryptamine 1B receptor HTR1B 0.0345
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0339
163 D(1B) dopamine receptor DRD5 0.0338
528 5-hydroxytryptamine 1E receptor HTR1E 0.0338
290 Prostaglandin G/H synthase 2 PTGS2 0.033
725 5-hydroxytryptamine 1D receptor HTR1D 0.0321
716 5-hydroxytryptamine 7 receptor HTR7 0.032
1256 5-hydroxytryptamine 6 receptor HTR6 0.0318
2129 Sucrase-isomaltase, intestinal SI 0.0317
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0314
1729 Solute carrier family 22 member 6 SLC22A6 0.0303
465 Calmodulin CALM1 0.0296
193 Beta-1 adrenergic receptor ADRB1 0.0294
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0292
3811 Cytochrome P450 19A1 CYP19A1 0.0282
862 Multidrug resistance-associated protein 1 ABCC1 0.0281
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0276
467 Delta-type opioid receptor OPRD1 0.0265
847 Mu-type opioid receptor OPRM1 0.0264
124 Histamine H2 receptor HRH2 0.0261
731 HIV-1 protease HIV-1 protease 0.0261
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0257
1898 Cytochrome P450 1B1 CYP1B1 0.0256
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0255
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0255
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0252
696 Kappa-type opioid receptor OPRK1 0.025
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0243
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0239
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0235
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0231
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0221
6147 Solute carrier family 22 member 3 SLC22A3 0.0211
260 Cytochrome P450 51 ERG11 0.0208
761 Cytochrome P450 51 ERG11 0.0208
3163 Cytochrome P450 51 cyp51 0.0208
3941 Amine oxidase [flavin-containing] A MAOA 0.0207
136 Estrogen receptor ESR1 0.0205
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0204
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.02
871 Glucocorticoid receptor NR3C1 0.0197
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0186
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0186
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0182
776 Bile salt export pump ABCB11 0.0179
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0177
474 Acetylcholinesterase ACHE 0.0176
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0174
6142 Solute carrier family 22 member 8 SLC22A8 0.0173
6432 Transporter snf 0.0169
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0167
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0166
1656 CYP2B protein CYP2B 0.0161
891 Dihydropteroate synthase folP 0.0157
5359 Dihydropteroate synthase folP 0.0157
7175 Dihydropteroate synthase sulI 0.0157
2164 Multidrug resistance-associated protein 4 ABCC4 0.0156
122 P2Y purinoceptor 12 P2RY12 0.0156
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0153
3939 Amine oxidase [flavin-containing] B MAOB 0.0153
723 Cytosolic phospholipase A2 PLA2G4A 0.0152
6182 Cytochrome P450 2J2 CYP2J2 0.0151
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.015
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0147
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0146
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0143
6031 Cytochrome P450 3A43 CYP3A43 0.0142
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0139
6143 Solute carrier family 22 member 7 SLC22A7 0.0138
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0134
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0134
146 Androgen receptor AR 0.0128
468 Cytochrome P450 4A11 CYP4A11 0.0126
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0125
817 DNA topoisomerase 2-alpha TOP2A 0.0124
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0122
70 Type-1 angiotensin II receptor AGTR1 0.0119
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0118
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0118
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0118
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0114
380 Cytochrome P450 17A1 CYP17A1 0.0114
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0114
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.011
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.011
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.011
94 5-hydroxytryptamine 4 receptor HTR4 0.0109
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0105
1360 Sphingomyelin phosphodiesterase SMPD1 0.0105
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0104
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0104
1618 High affinity nerve growth factor receptor NTRK1 0.0102
614 Progesterone receptor PGR 0.0101
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0097
49 Endothelin B receptor EDNRB 0.0096
1024 Solute carrier family 22 member 11 SLC22A11 0.0094
232 Corticosteroid-binding globulin SERPINA6 0.0093
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.009
578 Endothelin-1 receptor EDNRA 0.009
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0089
164 Histamine H4 receptor HRH4 0.0089
161 Tubulin beta chain TUBB 0.0086
312 Tubulin beta chain TUB2 0.0086
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0086
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0085
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0085
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0085
295 Carbonic anhydrase 1 CA1 0.0083
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0082
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0079
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0079
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0079
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0079
811 Translocator protein TSPO 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
844 Epidermal growth factor receptor EGFR 0.0077
6220 Aryl hydrocarbon receptor AHR 0.0077
777 Tumor necrosis factor TNF 0.0077
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0077
4604 Liver carboxylesterase 1 CES1 0.0077
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0077
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0076
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0076
6137 Multidrug resistance-associated protein 6 ABCC6 0.0075
504 Mast/stem cell growth factor receptor KIT 0.0075
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0075
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0075
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0075
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0075
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0074
6102 Arylamine N-acetyltransferase 2 NAT2 0.0074
407 Vascular endothelial growth factor receptor 2 KDR 0.0074
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0073
365 Dihydrofolate reductase DHFR 0.0073
2381 Dihydrofolate reductase DFR1 0.0073
2833 Dihydrofolate reductase Not Available 0.0073
2931 Dihydrofolate reductase folA 0.0073
3544 Dihydrofolate reductase folA 0.0073
3682 Dihydrofolate reductase folA 0.0073
6642 Dihydrofolate reductase folA 0.0073
6756 Dihydrofolate reductase dfrA 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
357 Carbonic anhydrase 2 CA2 0.0072
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0071
818 50S ribosomal protein L10 rplJ 0.0071
6136 Multidrug resistance-associated protein 5 ABCC5 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0069
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0069
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0069
6148 Multidrug resistance-associated protein 7 ABCC10 0.0068
952 Dipeptidyl peptidase 4 DPP4 0.0066
4120 NADPH--cytochrome P450 reductase POR 0.0066
6014 Cytochrome P450 2A13 CYP2A13 0.0066
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0066
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0066
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0066
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0065
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0065
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0064
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0063
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0063
133 Dihydropterate synthase sulI 0.0063
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0062
373 Transthyretin TTR 0.0061
183 Vascular endothelial growth factor A VEGFA 0.0061
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0061
756 Sex hormone-binding globulin SHBG 0.0061
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.006
6126 Carbonic anhydrase 7 CA7 0.006
1757 Myeloperoxidase MPO 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
3810 Catechol O-methyltransferase COMT 0.0059
1010 Cytochrome P450 51A1 CYP51A1 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0058
427 Substance-P receptor TACR1 0.0058
26 Vascular endothelial growth factor receptor 3 FLT4 0.0057
6141 Sodium/bile acid cotransporter SLC10A1 0.0057
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0056
32 Vascular endothelial growth factor receptor 1 FLT1 0.0055
6506 Stathmin-4 STMN4 0.0055
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0054
856 Vitamin D3 receptor VDR 0.0053
228 Beta platelet-derived growth factor receptor PDGFRB 0.0052
29 Tubulin beta-1 chain TUBB1 0.0052
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0052
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0052
2112 Toll-like receptor 9 TLR9 0.0051
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
482 Glycine receptor subunit alpha-1 GLRA1 0.005
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.005
869 Estrogen receptor beta ESR2 0.0049
921 Glutamate receptor 2 GRIA2 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0048
3947 Xanthine dehydrogenase/oxidase XDH 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0046
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0046
527 Prostacyclin receptor PTGIR 0.0045
814 Ryanodine receptor 1 RYR1 0.0045
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0045
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0045
738 Monocarboxylate transporter 1 SLC16A1 0.0045
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0044
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0044
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0044
275 Arachidonate 5-lipoxygenase ALOX5 0.0044
1275 Estrogen sulfotransferase SULT1E1 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0042
1629 Transcription factor AP-1 JUN 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
518 Peroxidase/catalase T katG 0.0041
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
737 Mineralocorticoid receptor NR3C2 0.004
6085 Fatty acid-binding protein, intestinal FABP2 0.004
3876 Aromatic-L-amino-acid decarboxylase DDC 0.004
581 Cytochrome P450 2R1 CYP2R1 0.0039
1541 Metalloproteinase mmp20 0.0039
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1178 Adenosine A2a receptor ADORA2A 0.0039
153 Dopamine beta-hydroxylase DBH 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0038
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
6043 Putative G-protein coupled receptor 44 GPR44 0.0038
4122 Histone deacetylase 2 HDAC2 0.0038
85 Growth hormone receptor GHR 0.0038
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0038
823 Fibroblast growth factor receptor 2 FGFR2 0.0037
563 Thyroid peroxidase TPO 0.0037
174 Sigma 1-type opioid receptor SIGMAR1 0.0037
208 DNA-directed RNA polymerase beta' chain rpoC 0.0037
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0037
54 Prothrombin F2 0.0037
284 DNA-directed RNA polymerase beta chain rpoB 0.0037
5773 DNA-directed RNA polymerase beta chain rpoB 0.0037
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0036
6020 Aldehyde oxidase AOX1 0.0036
1050 Bile salt sulfotransferase SULT2A1 0.0036
705 Glutamate receptor 1 GRIA1 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
634 Squalene monooxygenase SQLE 0.0035
7196 Squalene monooxygenase ERG1 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
24 Thymidylate synthase TMP1 0.0034
359 Thymidylate synthase TYMS 0.0034
2626 Thymidylate synthase thyA 0.0034
2729 Thymidylate synthase thyA 0.0034
5352 Thymidylate synthase THYA 0.0034
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0033
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0033
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0033
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0032
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0031
16 Adenosine A1 receptor ADORA1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
1517 Beta-3 adrenergic receptor ADRB3 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
88 Retinoic acid receptor RXR-beta RXRB 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
106 Cannabinoid receptor 2 CNR2 0.003
4311 tRNA TRDMT1 0.003
4325 tRNA trmD 0.003
4328 tRNA trmD 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.003
6174 50S ribosomal protein L32 rpmF 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
1196 Complement decay-accelerating factor CD55 0.0029
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0029
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0028
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
6146 High affinity copper uptake protein 1 SLC31A1 0.0028
1992 Vitamin D-binding protein GC 0.0028
1144 Hepatocyte growth factor receptor MET 0.0027
319 Opioid receptor, sigma 1 OPRS1 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
1192 Sulfotransferase 1A1 SULT1A1 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0027
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0027
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
537 ATP synthase delta chain, mitochondrial ATP5D 0.0027
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
165 FL cytokine receptor FLT3 0.0026
904 Glutathione S-transferase P GSTP1 0.0026
976 Platelet glycoprotein IX GP9 0.0026
1630 Integrin beta-2 ITGB2 0.0026
4103 Proteasome subunit beta type 2 PSMB2 0.0026
4102 Proteasome subunit beta type 5 PSMB5 0.0026
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0026
4101 Proteasome subunit beta type 1 PSMB1 0.0026
2808 Chloramphenicol acetyltransferase 3 cat3 0.0026
239 Coagulation factor X F10 0.0025
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0025
2981 Phospholipase A2, membrane associated PLA2G2A 0.0025
6138 Multidrug resistance protein 3 ABCB4 0.0025
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0025
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0025
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0025
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0025
1648 Elastin ELN 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
511 5-hydroxytryptamine 1F receptor HTR1F 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
5787 Angiopoietin-1 receptor TEK 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0023
3808 Dihydropteroate synthase 2 folP2 0.0023
3601 Dihydropteroate synthase 1 folP1 0.0023
3807 Dihydropteroate synthase 1 folP1 0.0023
3086 Plasmepsin-2 Not Available 0.0023
2417 Chloramphenicol acetyltransferase cat 0.0023
3278 Chloramphenicol acetyltransferase cat 0.0023
2810 Dr hemagglutinin structural subunit draA 0.0023
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0023
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0023
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0023
1341 Histamine H3 receptor HRH3 0.0023
84 Nuclear receptor 0B1 NR0B1 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
7 Nitric oxide synthase, inducible NOS2 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
3404 Exotoxin A eta 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
6044 Serum paraoxonase/lactonase 3 PON3 0.0021
3809 Estrogen-related receptor gamma ESRRG 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
572 Integrin alpha-L ITGAL 0.002
3868 Calcineurin subunit B isoform 2 PPP3R2 0.002
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0019
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0019
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
273 Apoptosis regulator Bcl-2 BCL2 0.0019
1864 RET proto-oncogene RET 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0019
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0019
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
469 Annexin A1 ANXA1 0.0018
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0018
1253 Interferon gamma IFNG 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
683 Potassium transporter GK0582 0.0018
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0018
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0018
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0018
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0018
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0017
251 Alcohol dehydrogenase 1A ADH1A 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
1374 Natriuretic peptides B NPPB 0.0017
5934 Cytochrome P450 26A1 CYP26A1 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
3830 Calreticulin CALR 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
820 Glycine receptor subunit alpha-2 GLRA2 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
3233 Bile acid receptor NR1H4 0.0015
33 Cystine/glutamate transporter SLC7A11 0.0015
444 Alcohol dehydrogenase 1B ADH1B 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0014
6824 Tyrosine-protein kinase Lyn LYN 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
267 Plasminogen activator inhibitor 1 SERPINE1 0.0014
3913 Glutamic acid decarboxylase GAD65 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
6218 Pannexin-1 PANX1 0.0013
291 Nitric-oxide synthase, endothelial NOS3 0.0013
6221 Steroid hormone receptor ERR1 ESRRA 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
2021 Thrombomodulin THBD 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
172 Potassium channel subfamily K member 1 KCNK1 0.001
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
3957 Adenosine deaminase ADA 0.001
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
2207 Rhodopsin RHO 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
489 Monocarboxylate transporter 2 SLC16A7 0.0008
1867 Major prion protein PRNP 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
2298 Cytochrome P450-cam camC 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
125 DNA polymerase beta POLB 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
908 Glutathione S-transferase theta-1 GSTT1 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
3221 Cytochrome c4 cc4 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
162 Retinoic acid receptor gamma-1 RARG 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1507 Cytochrome c CYCS 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3917 Methylenetetrahydrofolate reductase MTHFR 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
↑