DT-Web: DB00502

Identification

Name

Haloperidol

Accession Number

DB00502 (APRD00538)

Type

small molecule

Description

A phenyl-piperidinyl-butyrophenone that is used primarily to treat schizophrenia and other psychoses. It is also used in schizoaffective disorder, delusional disorders, ballism, and tourette syndrome (a drug of choice) and occasionally as adjunctive therapy in mental retardation and the chorea of huntington disease. It is a potent antiemetic and is used in the treatment of intractable hiccups. (From AMA Drug Evaluations Annual, 1994, p279)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

375.864

Groups

approved

Monoisotopic Weight

375.140134897

Pharmacology

Indication

For the management of psychotic disorders (eg. schizophrenia) and delirium, as well as to control tics and vocal utterances of Tourette's syndrome (Gilles de la Tourette's syndrome). Also used for the treatment of severe behavioural problems in children with disrubtive behaviour disorder or ADHD (attention-deficit hyperactivity disorder). Haloperidol has been used in the prevention and control of severe nausea and vomiting.

Mechanism of action

The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, but the drug appears to depress the CNS at the subcortical level of the brain, midbrain, and brain stem reticular formation. Haloperidol seems to inhibit the ascending reticular activating system of the brain stem (possibly through the caudate nucleus), thereby interrupting the impulse between the diencephalon and the cortex. The drug may antagonize the actions of glutamic acid within the extrapyramidal system, and inhibitions of catecholamine receptors may also contribute to haloperidol's mechanism of action. Haloperidol may also inhibit the reuptake of various neurotransmitters in the midbrain, and appears to have a strong central antidopaminergic and weak central anticholinergic activity. The drug produces catalepsy and inhibits spontaneous motor activity and conditioned avoidance behaviours in animals. The exact mechanism of antiemetic action of haloperidol has also not been fully determined, but the drug has been shown to directly affect the chemoreceptor trigger zone (CTZ) through the blocking of dopamine receptors in the CTZ.

Absorption

Oral-60%

Protein binding

92%

Biotransformation

Hepatic

Route of elimination

Not Available

Toxicity

LD₅₀=165 mg/kg (rats, oral)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Anisotropine Methylbromide	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atomoxetine	The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Atropine	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Benzatropine	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Biperiden	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Carbamazepine	Carbamazepine may decrease the serum concentration of haloperidol by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of haloperidol if carbamazepine is initiated, discontinued or dose changed.
Clidinium	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Clozapine	Clozapine, a moderate CYP2D6 inhibitor, may increase the serum concentration of haloperidol by decreasing its metabolism. Additive CNS despresant and anticholinergic effects may also occur. Monitor for changes in the therapeutic and adverse effects of haloperidol if clozapine is initiated, discontinued or dose changed. Also monitor for increased CNS depressant and anticholinergic effects during concomitant therapy.
Dicyclomine	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Ethopropazine	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Fluconazole	Fluconazole may increase the effect and toxicity of haloperidol.
Glycerol Phenylbutyrate	Haloperidol may induce hyperammonemia. Monitor ammonia levels closely when use of haloperidol is necessary in UCD patients.
Glycopyrrolate	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Guanethidine	Haloperidol may decrease the effect of guanethidine.
Homatropine Methylbromide	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Hyoscyamine	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Indacaterol	Concomitant therapy with monoamine oxidase inhibitors, tricyclic antidepressants, or other drugs that prolong the QTc interval should be monitored closely. These drugs may potentiate the effect of adrenergic agonist on the cardiovascular system.
Isopropamide	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Itraconazole	Itraconazole may increase the effect and toxicity of haloperidol.
Ketoconazole	Ketoconazole may increase the effect and toxicity of haloperidol.
Lithium	Possible extrapyramidal effects and neurotoxicity with this combination
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mepenzolate	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Methantheline	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Methyldopa	Methyldopa increases haloperidol effect or risk of psychosis
Orphenadrine	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Oxyphencyclimine	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Procyclidine	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Propantheline	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Propranolol	Increased effect of both drugs
Rifabutin	The rifamycin decreases the effect of haloperidol
Rifampin	The rifamycin decreases the effect of haloperidol
Scopolamine	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Haloperidol, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tamoxifen	Haloperidol may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Haloperidol, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Haloperidol is initiated, discontinued, or dose changed.
Telithromycin	Telithromycin may reduce clearance of Haloperidol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Haloperidol if Telithromycin is initiated, discontinued or dose changed.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Haloperidol. Consider alternate therapy or monitor for therapeutic/adverse effects of Haloperidol if Terbinafine is initiated, discontinued or dose changed.
Tetrabenazine	May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects. May cause dopamine deficiency. Similar pharmacologic properties thus combination therapy will worsen the severity of sedative, parkinsonian, and extrapyramidal adverse effects.
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tolterodine	Haloperidol may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	Haloperidol may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Haloperidol may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone	The CYP3A4 inhibitor, Haloperidol, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. The CYP2D6 inhibitor, Trazodone, may increase the efficacy of Haloperidol by decreasing Haloperidol metabolism and clearance. Monitor for changes in Trazodone and Haloperidol efficacy/toxicity if either agent is initiated, discontinued or dose changed.
Tridihexethyl	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Trihexyphenidyl	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Trimethobenzamide	Trimethobenzamide and Haloperidol, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine	Triprolidine and Haloperidol, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Haloperidol, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of haloperidol by decreasing its metabolism. Additive QTc prolongation may also occur. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of haloperidol if voriconazole is initiated, discontinued or dose changed.
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Take with food to reduce irritation, limit caffeine intake. Avoid alcohol.

D(2) dopamine receptor
Name	D(2) dopamine receptor
Gene Name	DRD2
Pharmacological action	yes
Actions	antagonist
References	Osinski MA, Uchic ME, Seifert T, Shaughnessy TK, Miller LN, Nakane M, Cox BF, Brioni JD, Moreland RB: Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol Biochem Behav. 2005 May;81(1):211-9. - Pubmed Bustillo J, Barrow R, Paz R, Tang J, Seraji-Bozorgzad N, Moore GJ, Bolognani F, Lauriello J, Perrone-Bizzozero N, Galloway MP: Long-term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levels. Neuropsychopharmacology. 2006 Apr;31(4):751-6. - Pubmed Ishiwata K, Oda K, Sakata M, Kimura Y, Kawamura K, Oda K, Sasaki T, Naganawa M, Chihara K, Okubo Y, Ishii K: A feasibility study of [11C]SA4503-PET for evaluating sigmal receptor occupancy by neuroleptics: the binding of haloperidol to sigma1 and dopamine D2-like receptors. Ann Nucl Med. 2006 Oct;20(8):569-73. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Naiker DV, Catts SV, Catts VS, Bedi KS, Bryan-Lluka LJ: Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D2-receptor occupancy method in the rat. Eur J Pharmacol. 2006 Jul 1;540(1-3):87-90. Epub 2006 May 11. - Pubmed Uchida S, Kato Y, Hirano K, Kagawa Y, Yamada S: Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine. Life Sci. 2007 Apr 3;80(17):1635-40. Epub 2007 Jan 27. - Pubmed Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. - Pubmed Seeman P: Dopamine D2 receptors as treatment targets in schizophrenia. Clin Schizophr Relat Psychoses. 2010 Apr;4(1):56-73. - Pubmed
DTHybrid score	0.5799
D(1A) dopamine receptor
Name	D(1A) dopamine receptor
Gene Name	DRD1
Pharmacological action	unknown
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Cai G, Gurdal H, Smith C, Wang HY, Friedman E: Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein. Mol Pharmacol. 1999 Nov;56(5):989-96. - Pubmed
DTHybrid score	0.4081
Glutamate [NMDA] receptor subunit epsilon-2
Name	Glutamate [NMDA] receptor subunit epsilon-2
Gene Name	GRIN2B
Pharmacological action	unknown
Actions	antagonist
References	Hattori K, Uchino S, Isosaka T, Maekawa M, Iyo M, Sato T, Kohsaka S, Yagi T, Yuasa S: Fyn is required for haloperidol-induced catalepsy in mice. J Biol Chem. 2006 Mar 17;281(11):7129-35. Epub 2006 Jan 10. - Pubmed Zhuravliova E, Barbakadze T, Natsvlishvili N, Mikeladze DG: Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity. Neurochem Int. 2007 Jun;50(7-8):976-82. Epub 2006 Nov 7. - Pubmed Gu WH, Yang S, Shi WX, Zhen XC, Jin GZ: Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine. Acta Pharmacol Sin. 2007 Jul;28(7):953-8. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Steinmetz RD, Fava E, Nicotera P, Steinhilber D: A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands. J Neurosci Methods. 2002 Jan 15;113(1):99-110. - Pubmed Sinor JD, Du S, Venneti S, Blitzblau RC, Leszkiewicz DN, Rosenberg PA, Aizenman E: NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. J Neurosci. 2000 Dec 1;20(23):8831-7. - Pubmed Gallagher MJ, Huang H, Lynch DR: Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions. J Neurochem. 1998 May;70(5):2120-8. - Pubmed
DTHybrid score	0.1794
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	unknown
Actions	other/unknown
References	Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. - Pubmed
DTHybrid score	0.4263
D(3) dopamine receptor
Name	D(3) dopamine receptor
Gene Name	DRD3
Pharmacological action	unknown
Actions	inverse agonist
References	Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. - Pubmed Tuppurainen H, Kuikka JT, Viinamaki H, Husso M, Tiihonen J: Dopamine D2/3 receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol, olanzapine and clozapine. Psychiatry Clin Neurosci. 2009 Aug;63(4):529-37. Epub 2009 May 22. - Pubmed Tadori Y, Forbes RA, McQuade RD, Kikuchi T: Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors. Eur J Pharmacol. 2008 Nov 12;597(1-3):27-33. Epub 2008 Sep 20. - Pubmed Kessler RM, Ansari MS, Riccardi P, Li R, Jayathilake K, Dawant B, Meltzer HY: Occupancy of striatal and extrastriatal dopamine D2/D3 receptors by olanzapine and haloperidol. Neuropsychopharmacology. 2005 Dec;30(12):2283-9. - Pubmed Malmberg, Mikaels, Mohell N: Agonist and inverse agonist activity at the dopamine D3 receptor measured by guanosine 5'--gamma-thio-triphosphate--35S- binding. J Pharmacol Exp Ther. 1998 Apr;285(1):119-26. - Pubmed
DTHybrid score	0.2776

Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5351
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4204
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Tateishi T, Watanabe M, Kumai T, Tanaka M, Moriya H, Yamaguchi S, Satoh T, Kobayashi S: CYP3A is responsible for N-dealkylation of haloperidol and bromperidol and oxidation of their reduced forms by human liver microsomes. Life Sci. 2000 Nov 3;67(24):2913-20. - Pubmed
DTHybrid score	0.6508
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor,inducer
References	Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed Otani K, Aoshima T: Pharmacogenetics of classical and new antipsychotic drugs. Ther Drug Monit. 2000 Feb;22(1):118-21. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7886
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Kalgutkar AS, Taylor TJ, Venkatakrishnan K, Isin EM: Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway. Drug Metab Dispos. 2003 Mar;31(3):243-9. - Pubmed
DTHybrid score	0.9819
Carbonyl reductase [NADPH] 1
Name	Carbonyl reductase [NADPH] 1
Gene Name	CBR1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.663
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.2738
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3267
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5898
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6175

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Boulton DW, DeVane CL, Liston HL, Markowitz JS: In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 2002 May 31;71(2):163-9. - Pubmed
DTHybrid score	0.5959

Id	Partner name	Gene Name	Score
4924	Cytochrome P450 2C8	CYP2C8	0.3444
6030	Cytochrome P450 2B6	CYP2B6	0.271
6013	Cytochrome P450 2E1	CYP2E1	0.251
320	5-hydroxytryptamine 1A receptor	HTR1A	0.2034
556	Alpha-1A adrenergic receptor	ADRA1A	0.1963
590	5-hydroxytryptamine 2C receptor	HTR2C	0.1943
318	Alpha-2A adrenergic receptor	ADRA2A	0.1814
432	D(4) dopamine receptor	DRD4	0.1775
587	Serum albumin	ALB	0.1764
492	Histamine H1 receptor	HRH1	0.164
5718	Cytochrome P450 2A6	CYP2A6	0.163
20	Prostaglandin G/H synthase 1	PTGS1	0.146
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1422
163	D(1B) dopamine receptor	DRD5	0.1421
5354	DevB protein	VC_A0897	0.138
629	Alpha-2B adrenergic receptor	ADRA2B	0.1376
632	Alpha-1B adrenergic receptor	ADRA1B	0.1369
378	Alpha-2C adrenergic receptor	ADRA2C	0.1325
103	Muscarinic acetylcholine receptor M1	CHRM1	0.1269
842	Chloride channel protein 2	CLCN2	0.1214
824	Sodium-dependent serotonin transporter	SLC6A4	0.1157
725	5-hydroxytryptamine 1D receptor	HTR1D	0.1123
6145	Solute carrier family 22 member 1	SLC22A1	0.1121
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1115
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1097
436	5-hydroxytryptamine 2B receptor	HTR2B	0.1079
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.1074
716	5-hydroxytryptamine 7 receptor	HTR7	0.0997
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0995
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0994
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0964
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0896
6106	Cytochrome P450 2C18	CYP2C18	0.0888
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0882
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0879
1898	Cytochrome P450 1B1	CYP1B1	0.084
6144	Solute carrier family 22 member 2	SLC22A2	0.0839
862	Multidrug resistance-associated protein 1	ABCC1	0.0833
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0827
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0818
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0813
290	Prostaglandin G/H synthase 2	PTGS2	0.0803
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0801
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0789
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0768
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0764
1729	Solute carrier family 22 member 6	SLC22A6	0.0744
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0684
789	Alpha-1D adrenergic receptor	ADRA1D	0.0667
847	Mu-type opioid receptor	OPRM1	0.0623
776	Bile salt export pump	ABCB11	0.062
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0619
696	Kappa-type opioid receptor	OPRK1	0.0601
131	Synaptic vesicular amine transporter	SLC18A2	0.0594
766	Beta-2 adrenergic receptor	ADRB2	0.0593
193	Beta-1 adrenergic receptor	ADRB1	0.0593
713	Sodium-dependent dopamine transporter	SLC6A3	0.0582
3811	Cytochrome P450 19A1	CYP19A1	0.058
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0572
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0557
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0553
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0551
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0551
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0542
3941	Amine oxidase [flavin-containing] A	MAOA	0.0538
3923	Cholinesterase	BCHE	0.0534
465	Calmodulin	CALM1	0.0523
467	Delta-type opioid receptor	OPRD1	0.0502
118	Organic cation/carnitine transporter 2	SLC22A5	0.049
871	Glucocorticoid receptor	NR3C1	0.0471
6031	Cytochrome P450 3A43	CYP3A43	0.0436
817	DNA topoisomerase 2-alpha	TOP2A	0.0429
136	Estrogen receptor	ESR1	0.0428
731	HIV-1 protease	HIV-1 protease	0.0413
2164	Multidrug resistance-associated protein 4	ABCC4	0.0411
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0405
6147	Solute carrier family 22 member 3	SLC22A3	0.04
6142	Solute carrier family 22 member 8	SLC22A8	0.0394
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0391
6143	Solute carrier family 22 member 7	SLC22A7	0.0388
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0376
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0373
3939	Amine oxidase [flavin-containing] B	MAOB	0.0367
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0365
260	Cytochrome P450 51	ERG11	0.0363
761	Cytochrome P450 51	ERG11	0.0363
3163	Cytochrome P450 51	cyp51	0.0363
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0358
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0357
174	Sigma 1-type opioid receptor	SIGMAR1	0.0356
3810	Catechol O-methyltransferase	COMT	0.0348
468	Cytochrome P450 4A11	CYP4A11	0.0347
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0347
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0345
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0338
94	5-hydroxytryptamine 4 receptor	HTR4	0.0331
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0326
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0322
4604	Liver carboxylesterase 1	CES1	0.0317
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0311
6148	Multidrug resistance-associated protein 7	ABCC10	0.0311
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0304
6182	Cytochrome P450 2J2	CYP2J2	0.0301
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0299
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0297
833	Organic cation/carnitine transporter 1	SLC22A4	0.0294
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0294
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0293
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0292
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0291
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0289
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.028
124	Histamine H2 receptor	HRH2	0.0278
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0264
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0262
6102	Arylamine N-acetyltransferase 2	NAT2	0.0259
36	Insulin receptor	INSR	0.0258
777	Tumor necrosis factor	TNF	0.0253
477	DNA topoisomerase 4 subunit A	parC	0.0253
886	DNA topoisomerase 4 subunit A	parC	0.0253
6226	DNA topoisomerase 4 subunit A	parC	0.0253
614	Progesterone receptor	PGR	0.0251
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0251
404	DNA gyrase subunit A	gyrA	0.0249
6224	DNA gyrase subunit A	gyrA	0.0249
474	Acetylcholinesterase	ACHE	0.0248
122	P2Y purinoceptor 12	P2RY12	0.0242
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0242
6137	Multidrug resistance-associated protein 6	ABCC6	0.0239
504	Mast/stem cell growth factor receptor	KIT	0.0237
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0232
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0231
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.023
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.023
844	Epidermal growth factor receptor	EGFR	0.023
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0229
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0224
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.022
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0216
1757	Myeloperoxidase	MPO	0.0215
380	Cytochrome P450 17A1	CYP17A1	0.0215
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0214
4120	NADPH--cytochrome P450 reductase	POR	0.0213
146	Androgen receptor	AR	0.0212
26	Vascular endothelial growth factor receptor 3	FLT4	0.0209
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0208
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0206
891	Dihydropteroate synthase	folP	0.0206
5359	Dihydropteroate synthase	folP	0.0206
7175	Dihydropteroate synthase	sulI	0.0206
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0204
738	Monocarboxylate transporter 1	SLC16A1	0.0204
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0204
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0204
1024	Solute carrier family 22 member 11	SLC22A11	0.0202
32	Vascular endothelial growth factor receptor 1	FLT1	0.02
6014	Cytochrome P450 2A13	CYP2A13	0.02
3947	Xanthine dehydrogenase/oxidase	XDH	0.02
407	Vascular endothelial growth factor receptor 2	KDR	0.0199
737	Mineralocorticoid receptor	NR3C2	0.0198
6220	Aryl hydrocarbon receptor	AHR	0.0198
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0196
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0193
3866	Serum amyloid A protein	SAA1	0.019
1200	AMBP protein	AMBP	0.019
1932	Apolipoprotein E	APOE	0.019
756	Sex hormone-binding globulin	SHBG	0.0188
921	Glutamate receptor 2	GRIA2	0.0187
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0187
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0184
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0182
923	Glutamate receptor 3	GRIA3	0.0178
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0178
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0178
3426	Glutamine synthetase	glnA	0.0176
3987	Glutamine synthetase	GLUL	0.0176
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0174
70	Type-1 angiotensin II receptor	AGTR1	0.017
6141	Sodium/bile acid cotransporter	SLC10A1	0.0168
811	Translocator protein	TSPO	0.0168
427	Substance-P receptor	TACR1	0.0167
232	Corticosteroid-binding globulin	SERPINA6	0.0166
1010	Cytochrome P450 51A1	CYP51A1	0.0166
818	50S ribosomal protein L10	rplJ	0.0165
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0164
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0163
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0163
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0163
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0163
1656	CYP2B protein	CYP2B	0.0162
6136	Multidrug resistance-associated protein 5	ABCC5	0.0159
1192	Sulfotransferase 1A1	SULT1A1	0.0158
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0157
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0156
1517	Beta-3 adrenergic receptor	ADRB3	0.0156
275	Arachidonate 5-lipoxygenase	ALOX5	0.0156
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0155
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0154
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0153
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0153
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0153
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0153
2449	Tubulin alpha-3 chain	TUBA1A	0.0148
723	Cytosolic phospholipase A2	PLA2G4A	0.0148
1178	Adenosine A2a receptor	ADORA2A	0.0148
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0148
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0148
161	Tubulin beta chain	TUBB	0.0147
312	Tubulin beta chain	TUB2	0.0147
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0144
2499	Tubulin beta-2C chain	TUBB2C	0.0144
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0144
16	Adenosine A1 receptor	ADORA1	0.0144
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0141
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0141
869	Estrogen receptor beta	ESR2	0.0139
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0137
571	Melatonin receptor type 1A	MTNR1A	0.0136
362	Melatonin receptor type 1B	MTNR1B	0.0136
54	Prothrombin	F2	0.0136
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0136
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0131
153	Dopamine beta-hydroxylase	DBH	0.013
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0129
952	Dipeptidyl peptidase 4	DPP4	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
273	Apoptosis regulator Bcl-2	BCL2	0.0125
29	Tubulin beta-1 chain	TUBB1	0.0123
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
373	Transthyretin	TTR	0.0121
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0121
823	Fibroblast growth factor receptor 2	FGFR2	0.012
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.012
33	Cystine/glutamate transporter	SLC7A11	0.012
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0118
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0117
295	Carbonic anhydrase 1	CA1	0.0117
48	Pyridoxal kinase	PDXK	0.0116
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0114
165	FL cytokine receptor	FLT3	0.0113
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0112
6432	Transporter	snf	0.0112
1353	DNA topoisomerase 1	TOP1	0.0112
3552	DNA topoisomerase 1	topA	0.0112
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0111
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0111
705	Glutamate receptor 1	GRIA1	0.011
4203	Histamine N-methyltransferase	HNMT	0.011
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.011
1618	High affinity nerve growth factor receptor	NTRK1	0.011
1050	Bile salt sulfotransferase	SULT2A1	0.011
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0109
2112	Toll-like receptor 9	TLR9	0.0109
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0109
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0109
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0109
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0109
6020	Aldehyde oxidase	AOX1	0.0109
4237	50S ribosomal protein L22	rplV	0.0106
592	Carbonic anhydrase 4	CA4	0.0105
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0104
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0104
4122	Histone deacetylase 2	HDAC2	0.0104
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0103
6151	Monocarboxylate transporter 10	SLC16A10	0.0102
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0101
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0101
6085	Fatty acid-binding protein, intestinal	FABP2	0.01
6043	Putative G-protein coupled receptor 44	GPR44	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0099
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0099
2539	Tubulin alpha-1 chain	TUBA4A	0.0098
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0097
3932	Glutathione S-transferase A2	GSTA2	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
814	Ryanodine receptor 1	RYR1	0.0097
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0097
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0096
459	Retinoic acid receptor RXR-alpha	RXRA	0.0096
49	Endothelin B receptor	EDNRB	0.0096
6103	Arylamine N-acetyltransferase 1	NAT1	0.0096
7	Nitric oxide synthase, inducible	NOS2	0.0095
1275	Estrogen sulfotransferase	SULT1E1	0.0095
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0095
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0094
365	Dihydrofolate reductase	DHFR	0.0094
2381	Dihydrofolate reductase	DFR1	0.0094
2833	Dihydrofolate reductase	Not Available	0.0094
2931	Dihydrofolate reductase	folA	0.0094
3544	Dihydrofolate reductase	folA	0.0094
3682	Dihydrofolate reductase	folA	0.0094
6642	Dihydrofolate reductase	folA	0.0094
6756	Dihydrofolate reductase	dfrA	0.0094
4238	50S ribosomal protein L4	rplD	0.0094
5578	50S ribosomal protein L4	rplD	0.0094
6173	50S ribosomal protein L4	rplD	0.0094
6219	50S ribosomal protein L4	rplD	0.0094
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0093
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0093
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0093
68	Cannabinoid receptor 1	CNR1	0.0092
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0092
578	Endothelin-1 receptor	EDNRA	0.009
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.009
239	Coagulation factor X	F10	0.009
4228	Keratin, type II cytoskeletal 7	KRT7	0.009
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.009
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.009
4311	tRNA	TRDMT1	0.009
4325	tRNA	trmD	0.009
4328	tRNA	trmD	0.009
164	Histamine H4 receptor	HRH4	0.0089
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0088
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0087
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0086
1629	Transcription factor AP-1	JUN	0.0086
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0086
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0086
183	Vascular endothelial growth factor A	VEGFA	0.0085
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0085
904	Glutathione S-transferase P	GSTP1	0.0084
1852	Microtubule-associated protein 2	MAP2	0.0084
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0084
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0084
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0084
790	DNA polymerase subunit alpha B	POLA2	0.0084
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0084
6168	Solute carrier family 22 member 16	SLC22A16	0.0083
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0083
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0083
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0083
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0082
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0082
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0082
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0081
976	Platelet glycoprotein IX	GP9	0.0081
84	Nuclear receptor 0B1	NR0B1	0.008
565	Extracellular calcium-sensing receptor	CASR	0.008
469	Annexin A1	ANXA1	0.0079
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0079
173	Toll-like receptor 7	TLR7	0.0079
357	Carbonic anhydrase 2	CA2	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
936	Ephrin type-A receptor 2	EPHA2	0.0077
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0077
489	Monocarboxylate transporter 2	SLC16A7	0.0077
319	Opioid receptor, sigma 1	OPRS1	0.0077
244	Angiotensin-converting enzyme	ACE	0.0076
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0076
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0076
780	Retinoic acid receptor RXR-gamma	RXRG	0.0076
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0076
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0075
267	Plasminogen activator inhibitor 1	SERPINE1	0.0075
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0074
6766	O-GlcNAcase BT_4395	BT_4395	0.0074
6044	Serum paraoxonase/lactonase 3	PON3	0.0074
3809	Estrogen-related receptor gamma	ESRRG	0.0074
482	Glycine receptor subunit alpha-1	GLRA1	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
4103	Proteasome subunit beta type 2	PSMB2	0.0073
4102	Proteasome subunit beta type 5	PSMB5	0.0073
4101	Proteasome subunit beta type 1	PSMB1	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
820	Glycine receptor subunit alpha-2	GLRA2	0.0072
5300	Antigen peptide transporter 1	TAP1	0.0072
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0072
6146	High affinity copper uptake protein 1	SLC31A1	0.0071
284	DNA-directed RNA polymerase beta chain	rpoB	0.0071
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0071
6126	Carbonic anhydrase 7	CA7	0.007
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.007
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.007
88	Retinoic acid receptor RXR-beta	RXRB	0.0068
291	Nitric-oxide synthase, endothelial	NOS3	0.0068
6221	Steroid hormone receptor ERR1	ESRRA	0.0068
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0068
106	Cannabinoid receptor 2	CNR2	0.0067
6859	Protein S100-A4	S100A4	0.0067
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0066
856	Vitamin D3 receptor	VDR	0.0066
6500	Phospholipase A2	PLA2G1B	0.0066
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0065
1196	Complement decay-accelerating factor	CD55	0.0065
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0064
5787	Angiopoietin-1 receptor	TEK	0.0064
5934	Cytochrome P450 26A1	CYP26A1	0.0064
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0064
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0064
1714	Mitogen-activated protein kinase 3	MAPK3	0.0064
5923	Microtubule-associated protein tau	MAPT	0.0064
5924	Microtubule-associated protein 4	MAP4	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
3904	Alanine aminotransferase 2	GPT2	0.0062
735	Alanine aminotransferase 1	GPT	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
4773	Deoxycytidine kinase	DCK	0.0062
76	Nitric-oxide synthase, brain	NOS1	0.0062
3937	Fatty-acid amide hydrolase	FAAH	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0059
581	Cytochrome P450 2R1	CYP2R1	0.0059
24	Thymidylate synthase	TMP1	0.0058
359	Thymidylate synthase	TYMS	0.0058
2626	Thymidylate synthase	thyA	0.0058
2729	Thymidylate synthase	thyA	0.0058
5352	Thymidylate synthase	THYA	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0058
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0058
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0057
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
634	Squalene monooxygenase	SQLE	0.0057
7196	Squalene monooxygenase	ERG1	0.0057
1483	Membrane copper amine oxidase	AOC3	0.0057
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0057
1630	Integrin beta-2	ITGB2	0.0057
2808	Chloramphenicol acetyltransferase 3	cat3	0.0056
6174	50S ribosomal protein L32	rpmF	0.0056
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0055
6506	Stathmin-4	STMN4	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0055
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
4192	DNA topoisomerase 2-beta	TOP2B	0.0053
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0053
5798	Mitogen-activated protein kinase 11	MAPK11	0.0053
518	Peroxidase/catalase T	katG	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
6138	Multidrug resistance protein 3	ABCB4	0.0053
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
712	Tubulin alpha chain	TUB1	0.0052
1039	Histone deacetylase 9	HDAC9	0.0052
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0052
3601	Dihydropteroate synthase 1	folP1	0.0052
3807	Dihydropteroate synthase 1	folP1	0.0052
3808	Dihydropteroate synthase 2	folP2	0.0052
2417	Chloramphenicol acetyltransferase	cat	0.0052
3278	Chloramphenicol acetyltransferase	cat	0.0052
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0051
694	Matrix protein 2	M	0.0051
3957	Adenosine deaminase	ADA	0.0051
2810	Dr hemagglutinin structural subunit	draA	0.0051
2021	Thrombomodulin	THBD	0.0051
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.005
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
569	Retinal dehydrogenase 2	ALDH1A2	0.005
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0049
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0049
563	Thyroid peroxidase	TPO	0.0048
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
1374	Natriuretic peptides B	NPPB	0.0048
1827	Gap junction alpha-1 protein	GJA1	0.0048
1908	Vascular cell adhesion protein 1	VCAM1	0.0048
3856	Fibroblast growth factor receptor 3	FGFR3	0.0048
1176	Mitogen-activated protein kinase 1	MAPK1	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
1864	RET proto-oncogene	RET	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
611	Retinal dehydrogenase 1	ALDH1A1	0.0047
683	Potassium transporter	GK0582	0.0047
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0047
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0046
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0046
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
3086	Plasmepsin-2	Not Available	0.0046
1992	Vitamin D-binding protein	GC	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0045
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0045
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0044
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0044
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0044
719	Retinoic acid receptor responder protein 1	RARRES1	0.0044
770	Retinoic acid-induced protein 3	GPRC5A	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
3830	Calreticulin	CALR	0.0043
117	Sterol O-acyltransferase 1	SOAT1	0.0043
162	Retinoic acid receptor gamma-1	RARG	0.0043
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0043
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0043
572	Integrin alpha-L	ITGAL	0.0042
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
908	Glutathione S-transferase theta-1	GSTT1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0042
1648	Elastin	ELN	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
6048	Troponin C, skeletal muscle	TNNC2	0.0041
3913	Glutamic acid decarboxylase	GAD65	0.0041
6034	Hydroxyindole O-methyltransferase	ASMT	0.0041
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0041
6035	Nuclear receptor ROR-beta	RORB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6036	Eosinophil peroxidase	EPX	0.0041
751	Potassium channel subfamily K member 6	KCNK6	0.004
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.004
6149	Solute carrier family 22 member 10	SLC22A10	0.004
2236	Casein kinase II subunit alpha	CSNK2A1	0.004
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
1541	Metalloproteinase	mmp20	0.0039
251	Alcohol dehydrogenase 1A	ADH1A	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0039
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
484	Tyrosine-protein kinase ABL2	ABL2	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0038
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0038
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0038
922	Glutamate receptor 4	GRIA4	0.0038
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0038
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0038
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0038
4018	Glutamate receptor delta-2 subunit	GRID2	0.0038
4027	Glutamate receptor delta-1 subunit	GRID1	0.0038
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0038
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0038
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0038
4019	Excitatory amino acid transporter 4	SLC1A6	0.0038
4026	Aspartyl aminopeptidase	DNPEP	0.0038
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0038
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0038
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0038
1912	Excitatory amino acid transporter 1	SLC1A3	0.0038
4016	Excitatory amino acid transporter 5	SLC1A7	0.0038
1047	Excitatory amino acid transporter 2	SLC1A2	0.0038
927	Metabotropic glutamate receptor 8	GRM8	0.0038
925	Metabotropic glutamate receptor 4	GRM4	0.0038
664	Glutamate decarboxylase 2	GAD2	0.0038
3890	Glutamate decarboxylase 2	GAD2	0.0038
926	Metabotropic glutamate receptor 7	GRM7	0.0038
4020	Glutamyl aminopeptidase	ENPEP	0.0038
4017	5-oxoprolinase	OPLAH	0.0038
444	Alcohol dehydrogenase 1B	ADH1B	0.0038
6824	Tyrosine-protein kinase Lyn	LYN	0.0038
6042	Prostaglandin reductase 2	PTGR2	0.0038
1569	G1/S-specific cyclin-D1	CCND1	0.0038
85	Growth hormone receptor	GHR	0.0038
172	Potassium channel subfamily K member 1	KCNK1	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
765	Indoleamine 2,3-dioxygenase	IDO1	0.0035
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0035
1792	Tissue-type plasminogen activator	PLAT	0.0035
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0035
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
268	Adenosine A2b receptor	ADORA2B	0.0035
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0035
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0035
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
558	Solute carrier family 12 member 1	SLC12A1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0033
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0033
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0033
65	Matrix metalloproteinase-9	Not Available	0.0033
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0032
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0032
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0032
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0032
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0032
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0032
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0032
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0032
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
625	Glutamate carboxypeptidase 2	FOLH1	0.0032
665	Phosphoserine aminotransferase	PSAT1	0.0032
4652	Phosphoserine aminotransferase	serC	0.0032
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0032
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0032
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0032
420	Glutamate decarboxylase 1	GAD1	0.0032
3900	Glutamate decarboxylase 1	GAD1	0.0032
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0032
517	Alcohol dehydrogenase 1C	ADH1C	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
916	Metabotropic glutamate receptor 1	GRM1	0.003
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0029
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0029
1313	Lactoylglutathione lyase	GLO1	0.0029
3877	Growth-inhibiting protein 18	GIG18	0.0029
1671	Excitatory amino acid transporter 3	SLC1A1	0.0029
763	Tyrosine aminotransferase	TAT	0.0029
5493	Tyrosine aminotransferase	Not Available	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
896	Glutathione S-transferase Mu 1	GSTM1	0.0029
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0028
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0028
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0028
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0027
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0027
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0027
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0027
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0027
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0027
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0027
2216	Fibroblast growth factor receptor 4	FGFR4	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0026
6163	Copper-transporting ATPase 2	ATP7B	0.0026
6165	Copper-transporting ATPase 1	ATP7A	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0026
6131	Carbonic anhydrase 14	CA14	0.0026
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
4217	Telomerase reverse transcriptase	TERT	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0025
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0024
400	Coagulation factor IX	F9	0.0024
5461	Coagulation factor IX	F9	0.0024
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6122	Carbonic anhydrase 3	CA3	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
822	Aldose reductase	AKR1B1	0.0023
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0022
604	Vitamin K-dependent protein Z	PROZ	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
422	Vitamin K-dependent protein C	PROC	0.002
1245	Vitamin K-dependent protein S	PROS1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.002
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0019
2320	Thymidine kinase, cytosolic	TK1	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
2408	Tyrosine-protein kinase SYK	SYK	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
6218	Pannexin-1	PANX1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
798	Osteocalcin	BGLAP	0.0016
1243	Cathepsin D	CTSD	0.0016
3007	Carbonic anhydrase 12	CA12	0.0016
4205	Carbonic anhydrase 9	CA9	0.0016
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
1650	Heme carrier protein 1	SLC46A1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
369	Coagulation factor VII	F7	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
4210	Toll-like receptor 4	TLR4	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
4226	Uridine phosphorylase 2	UPP2	0.0014
2207	Rhodopsin	RHO	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
4225	Uridine phosphorylase 1	UPP1	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
413	Amidophosphoribosyltransferase	PPAT	0.0012
2515	Amidophosphoribosyltransferase	purF	0.0012
3714	Amidophosphoribosyltransferase	purF	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6459	Glycodelin	PAEP	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
3221	Cytochrome c4	cc4	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
1867	Major prion protein	PRNP	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
2298	Cytochrome P450-cam	camC	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
6677	Myelin P2 protein	PMP2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1507	Cytochrome c	CYCS	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00502 - Haloperidol

Targets

Enzymes

Transporters

Predictions