DT-Web

DB00193 - Tramadol


Identification
Name Tramadol
Accession Number DB00193 (APRD00028)
Type small molecule
Description A narcotic analgesic proposed for moderate to severe pain. It may be habituating. [PubChem] Tramadol is also prepared as a variable release capsules, marketed under the brand name ConZip. For example, a 150 mg capsule will contain 37.5 mg of the immediate release form and 112.5 mg of the extended release form.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 263.3752
Groups approved
Monoisotopic Weight 263.188529049
Pharmacology
Indication Indicated in the treatment of moderate to severe pain. Consider for those prone to constipation or respiratory depression. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
Mechanism of action Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. The analgesic properties of Tramadol can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord. The (+) enantiomer has higher affinity for the OP3 receptor and preferentially inhibits serotonin uptake and enhances serotonin release. The (-) enantiomer preferentially inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors.
Absorption Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Protein binding 20% bound to plasma proteins.
Biotransformation Hepatic. The major metabolic pathways appear to be N- and O- demethylation and glucuronidation or sulfation in the liver. One metabolite (O-desmethyltramadol, denoted M1) is pharmacologically active in animal models. CYP3A4 and CYP2B6 facilitates the biotransformation of tramadol to N-desmethyl-tramadol. CYP2D6 facilitates the biotransformation of tramadol to O-desmethyl-tramadol.
Route of elimination Tramadol is eliminated primarily through metabolism by the liver and the metabolites are excreted primarily by the kidneys. Approximately 30% of the dose is excreted in the urine as unchanged drug, whereas 60% of the dose is excreted as metabolites.
Toxicity LD50=350mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Almotriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Alvimopan Increases levels by receptor binding competition. Discontinue opioid administration at least 7 days prior to administrating Alvimopan.
Aminoglutethimide Aminoglutethimide may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Amiodarone Amiodarone may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Amiodarone may decrease the effect of Tramadol by decreasing active metabolite production.
Amitriptyline Tramadol increases the risk of serotonin syndrome and seizures.
Amoxapine Tramadol increases the risk of serotonin syndrome and seizures.
Amprenavir Amprenavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Aprepitant Aprepitant may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Atazanavir Atazanavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Benzphetamine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Bosentan Bosentan may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Bromocriptine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Cabergoline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Carbamazepine Carbamazepine may decrease the effect of tramadol by increasing Tramadol metabolism and clearance.
Chloroquine Chloroquine may decrease the effect of Tramadol by decreasing active metabolite production.
Chlorpromazine Chlorpromazine may decrease the effect of Tramadol by decreasing active metabolite production.
Cimetidine Cimetidine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Cimetidine may decrease the effect of Tramadol by decreasing active metabolite production.
Cinacalcet Cinacalcet may decrease the effect of Tramadol by decreasing active metabolite production.
Citalopram The use of two serotonin modulators, such as citalopram and tramadol, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Clarithromycin Clarithromycin may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Clomipramine Tramadol increases the risk of serotonin syndrome and seizures. Clomipramine may decrease the effect of Tramadol by decreasing active metabolite production.
Clotrimazole Clotrimazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Clozapine Clozapine may decrease the effect of Tramadol by decreasing active metabolite production.
Cocaine Cocaine may decrease the effect of Tramadol by decreasing active metabolite production.
Conivaptan Conivaptan may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Cyclobenzaprine Increases risk of seizure.
Cyclosporine Cyclosporine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Darifenacin Darifenacin may decrease the effect of Tramadol by decreasing active metabolite production.
Darunavir Darunavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Delavirdine Delavirdine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Delavirdine may decrease the effect of Tramadol by decreasing active metabolite production.
Desipramine Tramadol increases the risk of serotonin syndrome and seizures. Desipramine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Desipramine may decrease the effect of Tramadol by decreasing active metabolite production.
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dexamethasone Dexamethasone may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Dextroamphetamine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dextromethorphan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroergotamine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Diltiazem Diltiazem may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Diphenhydramine Diphenhydramine may decrease the effect of Tramadol by decreasing active metabolite production.
Doxepin Tramadol increases the risk of serotonin syndrome and seizures.
Duloxetine Duloxetine may decrease the effect of Tramadol by decreasing active metabolite production. Increased risk of serotonin syndrome. Monitor for Tramadol efficacy and symptoms of serotonin syndrome.
Efavirenz Efavirenz may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Eletriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ergoloid mesylate Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ergonovine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ergotamine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Erythromycin Erythromycin may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Escitalopram Tramadol may increase the risk of serotonin syndrome and seizures.
Etravirine Tramadol,when used concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration and efficacy due to increased tramadol metabolism and clearance.
Fluconazole Fluconazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Fluoxetine The use of two serotonin modulators, such as fluoxetine and tramadol, may increase the risk of serotonin syndrome. Fluoxetine may decrease the effect of tramadol by decreasing active metabolite production.
Fluvoxamine Tramadol may increase the risk of serotonin syndrome and seizures.
Fosamprenavir Fosamprenavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Fosphenytoin Fosphenytoin may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Frovatriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Furazolidone Tramadol increases the risk of serotonin syndrome and seizure induction by the MAO inhibitor, Furazolidone.
Haloperidol Haloperidol may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Haloperidol may decrease the effect of Tramadol by decreasing active metabolite production.
Imatinib Imatinib may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Imatinib may decrease the effect of Tramadol by decreasing active metabolite production.
Imipramine Tramadol increases the risk of serotonin syndrome and seizures. Imipramine may decrease the effect of Tramadol by decreasing active metabolite production.
Indinavir Indinavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Isocarboxazid Tramadol may increase the risk of serotonin syndrome and seizure induction by the MAO inhibitor, isocarboxazid.
Isoniazid Isoniazid may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Isoniazid may decrease the effect of Tramadol by decreasing active metabolite production.
Itraconazole Itraconazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Ketoconazole Ketoconazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Ketoconazole may decrease the effect of Tramadol by decreasing active metabolite production.
Lapatinib Lapatinib may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Lidocaine Lidocaine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Lidocaine may decrease the effect of Tramadol by decreasing active metabolite production.
Linezolid Tramadol increases the risk of serotonin syndrome and seizure induction by the MAO inhibitor, Linezolid.
Lisdexamfetamine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Lopinavir Lopinavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Lopinavir may decrease the effect of Tramadol by decreasing active metabolite production.
Maprotiline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Meperidine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Methadone Methadone may decrease the effect of Tramadol by decreasing active metabolite production.
Methamphetamine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Methotrimeprazine Additive CNS depressant effects. Decrease dose of tramadol by 50% if initiating methotrimeprazine therapy. Monitor for increased CNS depression and apply further dosage adjustments as required.
Methylergonovine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Metronidazole Metronidazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Miconazole Miconazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Miconazole may decrease the effect of Tramadol by decreasing active metabolite production.
Mirtazapine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Moclobemide Tramadol may increase the risk of serotonin syndrome and seizure induction by the MAO inhibitor, moclobemide.
Nafcillin Nafcillin may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Naratriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Nefazodone Nefazodone may increase tramadol toxicity by decreasing tramadol metabolism and clearance. Increased risk of serotonin syndrome. Monitor for tramadol toxicity and symptoms of serotonin syndrome.
Nelfinavir Nelfinavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Nevirapine Nevirapine may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Nicardipine Nicardipine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Nicardipine may decrease the effect of Tramadol by decreasing active metabolite production.
Nilotinib Nilotinib may decrease the effect of Tramadol by decreasing active metabolite production.
Norfloxacin Norfloxacin may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Nortriptyline Tramadol increases the risk of serotonin syndrome and seizures.
Oxcarbazepine Oxcarbazepine may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Paroxetine Tramadol may increase the risk of serotonin syndrome and seizures. Paroxetine may decrease the effect of Tramadol by decreasing active metabolite production.
Pentobarbital Pentobarbital may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Pergolide Pergolide may decrease the effect of Tramadol by decreasing active metabolite production. Increased risk of serotonin syndrome. Monitor for Tramadol efficacy and symptoms of serotonin syndrome.
Phendimetrazine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Phenelzine Tramadol may increase the risk of serotonin syndrome and seizure induction by the MAO inhibitor, phenelzine.
Phenobarbital Phenobarbital may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Phentermine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Phenytoin Phenytoin may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Pioglitazone Pioglitazone may decrease the effect of Tramadol by decreasing active metabolite production.
Posaconazole Posaconazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Primidone Primidone may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Procarbazine Tramadol increases the risk of serotonin syndrome and seizure induction by the MAO inhibitor, Procarbazine.
Promethazine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Protriptyline Tramadol increases the risk of serotonin syndrome and seizures.
Pyrimethamine Pyrimethamine may decrease the effect of Tramadol by decreasing active metabolite production.
Quinidine Quinidine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Quinidine may decrease the effect of Tramadol by decreasing active metabolite production.
Quinine Quinine may decrease the effect of Tramadol by decreasing active metabolite production.
Ranolazine Ranolazine may decrease the effect of Tramadol by decreasing active metabolite production.
Rasagiline Tramadol may increase the risk of serotonin syndrome and seizure induction by the MAO inhibitor, rasagiline.
Rifabutin Rifabutin may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Rifampin Rifampin may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Rifapentine Rifapentine may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Ritonavir Ritonavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Ritonavir may decrease the effect of Tramadol by decreasing active metabolite production.
Rizatriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
S-Adenosylmethionine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Saquinavir Saquinavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Selegiline Tramadol increases the risk of serotonin syndrome and seizure induction by the MAO inhibitor, Selegiline.
Sertraline Tramadol increases the risk of serotonin syndrome and seizures. Sertraline may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Sertraline may decrease the effect of Tramadol by decreasing active metabolite production.
Sibutramine Sibutramine may incrase the serotonergic effect of the Tramadol. Concomitant therapy should be avoided.
Sitaxentan Sitaxsentan may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
St. John's Wort Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Sumatriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Telithromycin Telithromycin may decrease the metabolism and clearance of tramadol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of tramadol if telithromycin is initiated, discontinued or dose changed.
Terbinafine Terbinafine may decrease the effect of Tramadol by decreasing active metabolite production.
Tetracycline Tetracycline may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Thioridazine Thioridazine may decrease the effect of Tramadol by decreasing active metabolite production.
Ticlopidine Ticlopidine may decrease the effect of Tramadol by decreasing active metabolite production.
Tranylcypromine Tramadol may increase the risk of serotonin syndrome and seizure induction by the MAO inhibitor, tranylcypromine. Tranylcypromine may decrease the effect of tramadol by decreasing active metabolite production.
Trazodone The use of two serotonin modulators, such as trazodone and tramadol, may increase the risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine Tramadol may increase the risk of serotonin syndrome and seizures.
Triprolidine The CNS depressants, Triprolidine and Tramadol, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Verapamil Verapamil may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of tramadol by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of tramadol if voriconazole is initiated, discontinued or dose changed.
Zolmitriptan The use of two serotonin modulators, such as zolmitriptan and tramadol, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Food Interactions
  • Oral administration of tramadol hydrochloride with food does not significantly affect its rate or extent of absorption, therefore, tramadol hydrochloride can be administered without regard to food.

Targets


Mu-type opioid receptor
Name Mu-type opioid receptor
Gene Name OPRM1
Pharmacological action yes
Actions agonist
References
  • Gillen C, Haurand M, Kobelt DJ, Wnendt S: Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor. Naunyn Schmiedebergs Arch Pharmacol. 2000 Aug;362(2):116-21. - Pubmed
  • Potschka H, Friderichs E, Loscher W: Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy. Br J Pharmacol. 2000 Sep;131(2):203-12. - Pubmed
  • Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL: Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther. 1992 Jan;260(1):275-85. - Pubmed
  • Grond S, Sablotzki A: Clinical pharmacology of tramadol. Clin Pharmacokinet. 2004;43(13):879-923. - Pubmed
  • Ide S, Minami M, Ishihara K, Uhl GR, Sora I, Ikeda K: Mu opioid receptor-dependent and independent components in effects of tramadol. Neuropharmacology. 2006 Sep;51(3):651-8. Epub 2006 Jun 21. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Minami K, Uezono Y, Ueta Y: Pharmacological aspects of the effects of tramadol on G-protein coupled receptors. J Pharmacol Sci. 2007 Mar;103(3):253-60. - Pubmed
  • Frink MC, Hennies HH, Englberger W, Haurand M, Wilffert B: Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung. 1996 Nov;46(11):1029-36. - Pubmed
DTHybrid score 1.0174
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action yes
Actions inhibitor
References
  • Sagata K, Minami K, Yanagihara N, Shiraishi M, Toyohira Y, Ueno S, Shigematsu A: Tramadol inhibits norepinephrine transporter function at desipramine-binding sites in cultured bovine adrenal medullary cells. Anesth Analg. 2002 Apr;94(4):901-6, table of contents. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Berrocoso E, Mico JA: Cooperative opioid and serotonergic mechanisms generate superior antidepressant-like effects in a mice model of depression. Int J Neuropsychopharmacol. 2009 Sep;12(8):1033-44. Epub 2009 Apr 3. - Pubmed
  • Frink MC, Hennies HH, Englberger W, Haurand M, Wilffert B: Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung. 1996 Nov;46(11):1029-36. - Pubmed
DTHybrid score 0.5455
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action yes
Actions inhibitor
References
  • Barann M, Urban B, Stamer U, Dorner Z, Bonisch H, Bruss M: Effects of tramadol and O-demethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: a possible mechanism for tramadol-induced early emesis. Eur J Pharmacol. 2006 Feb 15;531(1-3):54-8. Epub 2006 Jan 19. - Pubmed
  • Driessen B, Reimann W: Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro. Br J Pharmacol. 1992 Jan;105(1):147-51. - Pubmed
  • Frink MC, Hennies HH, Englberger W, Haurand M, Wilffert B: Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung. 1996 Nov;46(11):1029-36. - Pubmed
DTHybrid score 0.4493
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action unknown
Actions antagonist
References
  • Ogata J, Minami K, Uezono Y, Okamoto T, Shiraishi M, Shigematsu A, Ueta Y: The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesth Analg. 2004 May;98(5):1401-6, table of contents. - Pubmed
  • Horishita T, Minami K, Uezono Y, Shiraishi M, Ogata J, Okamoto T, Shigematsu A: The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes. Pharmacology. 2006;77(2):93-9. Epub 2006 May 5. - Pubmed
DTHybrid score 0.2342
Kappa-type opioid receptor
Name Kappa-type opioid receptor
Gene Name OPRK1
Pharmacological action unknown
Actions agonist
References
  • Sun HL, Zheng JW, Wang K, Liu RK, Liang JH: Tramadol reduces the 5-HTP-induced head-twitch response in mice via the activation of mu and kappa opioid receptors. Life Sci. 2003 Jan 31;72(11):1221-30. - Pubmed
DTHybrid score 0.816
Delta-type opioid receptor
Name Delta-type opioid receptor
Gene Name OPRD1
Pharmacological action no
Actions agonist
References
  • Wentland MP, Lou R, Lu Q, Bu Y, VanAlstine MA, Cohen DJ, Bidlack JM: Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. Epub 2008 Nov 7. - Pubmed
DTHybrid score 0.8411
Glutamate [NMDA] receptor subunit 3A
Name Glutamate [NMDA] receptor subunit 3A
Gene Name GRIN3A
Pharmacological action unknown
Actions antagonist
References
  • Hara K, Minami K, Sata T: The effects of tramadol and its metabolite on glycine, gamma-aminobutyric acidA, and N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Anesth Analg. 2005 May;100(5):1400-5, table of contents. - Pubmed
DTHybrid score 0.3297
Alpha-7 nicotinic cholinergic receptor subunit
Name Alpha-7 nicotinic cholinergic receptor subunit
Gene Name CHRFAM7A
Pharmacological action unknown
Actions antagonist
References
  • Shiraishi M, Minami K, Uezono Y, Yanagihara N, Shigematsu A, Shibuya I: Inhibitory effects of tramadol on nicotinic acetylcholine receptors in adrenal chromaffin cells and in Xenopus oocytes expressing alpha 7 receptors. Br J Pharmacol. 2002 May;136(2):207-16. - Pubmed
DTHybrid score 0.2582
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action unknown
Actions antagonist
References
  • Shiraishi M, Minami K, Uezono Y, Yanagihara N, Shigematsu A: Inhibition by tramadol of muscarinic receptor-induced responses in cultured adrenal medullary cells and in Xenopus laevis oocytes expressing cloned M1 receptors. J Pharmacol Exp Ther. 2001 Oct;299(1):255-60. - Pubmed
  • Shiga Y, Minami K, Shiraishi M, Uezono Y, Murasaki O, Kaibara M, Shigematsu A: The inhibitory effects of tramadol on muscarinic receptor-induced responses in Xenopus oocytes expressing cloned M(3) receptors. Anesth Analg. 2002 Nov;95(5):1269-73, table of contents. - Pubmed
DTHybrid score 0.3804

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6315
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.655
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3595

Predictions


Id Partner name Gene Name Score
103 Muscarinic acetylcholine receptor M1 CHRM1 0.2555
1588 Multidrug resistance protein 1 ABCB1 0.2522
4757 Cytochrome P450 2C9 CYP2C9 0.2429
6016 Cytochrome P450 2C19 CYP2C19 0.241
617 Muscarinic acetylcholine receptor M2 CHRM2 0.2345
713 Sodium-dependent dopamine transporter SLC6A3 0.2303
4200 Cytochrome P450 1A2 CYP1A2 0.2142
4118 Cytochrome P450 3A5 CYP3A5 0.184
4924 Cytochrome P450 2C8 CYP2C8 0.1773
502 5-hydroxytryptamine 2A receptor HTR2A 0.169
6107 Cytochrome P450 3A7 CYP3A7 0.165
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1435
492 Histamine H1 receptor HRH1 0.1397
556 Alpha-1A adrenergic receptor ADRA1A 0.1336
6013 Cytochrome P450 2E1 CYP2E1 0.1316
831 D(2) dopamine receptor DRD2 0.1288
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1184
1716 Tripartite motif-containing protein 13 TRIM13 0.115
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.1119
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.1085
318 Alpha-2A adrenergic receptor ADRA2A 0.1033
5718 Cytochrome P450 2A6 CYP2A6 0.1005
341 5-hydroxytryptamine 3 receptor HTR3A 0.0983
3923 Cholinesterase BCHE 0.0911
436 5-hydroxytryptamine 2B receptor HTR2B 0.0893
1262 Corticotropin-lipotropin POMC 0.0863
320 5-hydroxytryptamine 1A receptor HTR1A 0.0821
174 Sigma 1-type opioid receptor SIGMAR1 0.0788
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0759
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0756
23 D(1A) dopamine receptor DRD1 0.0735
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.073
632 Alpha-1B adrenergic receptor ADRA1B 0.071
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0677
6144 Solute carrier family 22 member 2 SLC22A2 0.0659
587 Serum albumin ALB 0.0635
6024 Cytochrome P450 1A1 CYP1A1 0.0631
629 Alpha-2B adrenergic receptor ADRA2B 0.0619
3941 Amine oxidase [flavin-containing] A MAOA 0.061
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0599
131 Synaptic vesicular amine transporter SLC18A2 0.0574
378 Alpha-2C adrenergic receptor ADRA2C 0.0566
3939 Amine oxidase [flavin-containing] B MAOB 0.0536
6106 Cytochrome P450 2C18 CYP2C18 0.0524
6145 Solute carrier family 22 member 1 SLC22A1 0.052
789 Alpha-1D adrenergic receptor ADRA1D 0.0496
638 D(3) dopamine receptor DRD3 0.0494
432 D(4) dopamine receptor DRD4 0.0469
319 Opioid receptor, sigma 1 OPRS1 0.0465
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0462
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0453
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0452
20 Prostaglandin G/H synthase 1 PTGS1 0.0435
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0427
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0415
885 5-hydroxytryptamine 1B receptor HTR1B 0.0405
766 Beta-2 adrenergic receptor ADRB2 0.0391
725 5-hydroxytryptamine 1D receptor HTR1D 0.039
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.039
4137 Nociceptin receptor OPRL1 0.0389
193 Beta-1 adrenergic receptor ADRB1 0.0369
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0358
3811 Cytochrome P450 19A1 CYP19A1 0.0352
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0331
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.032
163 D(1B) dopamine receptor DRD5 0.032
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0316
118 Organic cation/carnitine transporter 2 SLC22A5 0.0304
716 5-hydroxytryptamine 7 receptor HTR7 0.0303
465 Calmodulin CALM1 0.0277
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0275
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0263
136 Estrogen receptor ESR1 0.0236
833 Organic cation/carnitine transporter 1 SLC22A4 0.0233
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0229
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0227
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0222
1656 CYP2B protein CYP2B 0.0218
862 Multidrug resistance-associated protein 1 ABCC1 0.0217
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0212
1256 5-hydroxytryptamine 6 receptor HTR6 0.0211
6147 Solute carrier family 22 member 3 SLC22A3 0.0207
6432 Transporter snf 0.02
6182 Cytochrome P450 2J2 CYP2J2 0.0196
731 HIV-1 protease HIV-1 protease 0.019
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.019
871 Glucocorticoid receptor NR3C1 0.0186
474 Acetylcholinesterase ACHE 0.0184
482 Glycine receptor subunit alpha-1 GLRA1 0.0183
5838 Transient receptor potential cation channel subfamily V member 3 TRPV3 0.0176
2162 Transient receptor potential cation channel subfamily M member 8 TRPM8 0.0176
1944 Transient receptor potential cation channel subfamily A member 1 TRPA1 0.0176
4096 Metabotropic glutamate receptor 3 GRM3 0.0174
1362 Metabotropic glutamate receptor 2 GRM2 0.0174
1291 cAMP response element-binding protein CREB1 0.0172
94 5-hydroxytryptamine 4 receptor HTR4 0.0172
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.017
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.017
2178 Metabotropic glutamate receptor 5 GRM5 0.0167
1898 Cytochrome P450 1B1 CYP1B1 0.0166
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0163
468 Cytochrome P450 4A11 CYP4A11 0.0159
916 Metabotropic glutamate receptor 1 GRM1 0.0157
4210 Toll-like receptor 4 TLR4 0.0155
1636 Trace amine-associated receptor 1 TAAR1 0.0152
528 5-hydroxytryptamine 1E receptor HTR1E 0.0145
4120 NADPH--cytochrome P450 reductase POR 0.0143
776 Bile salt export pump ABCB11 0.0136
427 Substance-P receptor TACR1 0.0135
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0134
1729 Solute carrier family 22 member 6 SLC22A6 0.0131
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0127
1517 Beta-3 adrenergic receptor ADRB3 0.0125
260 Cytochrome P450 51 ERG11 0.0123
761 Cytochrome P450 51 ERG11 0.0123
3163 Cytochrome P450 51 cyp51 0.0123
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0123
124 Histamine H2 receptor HRH2 0.0123
694 Matrix protein 2 M 0.0121
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0121
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0119
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0118
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0117
362 Melatonin receptor type 1B MTNR1B 0.0115
571 Melatonin receptor type 1A MTNR1A 0.0115
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0105
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0104
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0104
122 P2Y purinoceptor 12 P2RY12 0.0103
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0102
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0102
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.01
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0099
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0098
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0098
290 Prostaglandin G/H synthase 2 PTGS2 0.0097
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0097
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0097
1618 High affinity nerve growth factor receptor NTRK1 0.0097
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0096
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0096
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
6142 Solute carrier family 22 member 8 SLC22A8 0.0091
537 ATP synthase delta chain, mitochondrial ATP5D 0.0091
818 50S ribosomal protein L10 rplJ 0.009
904 Glutathione S-transferase P GSTP1 0.009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0087
6031 Cytochrome P450 3A43 CYP3A43 0.0087
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0087
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0087
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0085
2164 Multidrug resistance-associated protein 4 ABCC4 0.0085
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0084
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0084
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0082
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0082
705 Glutamate receptor 1 GRIA1 0.008
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
146 Androgen receptor AR 0.0078
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0077
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0076
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0075
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0075
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0075
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0075
817 DNA topoisomerase 2-alpha TOP2A 0.0074
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0073
504 Mast/stem cell growth factor receptor KIT 0.0073
1757 Myeloperoxidase MPO 0.0073
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
161 Tubulin beta chain TUBB 0.0073
312 Tubulin beta chain TUB2 0.0073
614 Progesterone receptor PGR 0.0072
6220 Aryl hydrocarbon receptor AHR 0.0071
215 Sodium channel protein type 11 subunit alpha SCN11A 0.007
251 Alcohol dehydrogenase 1A ADH1A 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0069
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0067
1360 Sphingomyelin phosphodiesterase SMPD1 0.0066
952 Dipeptidyl peptidase 4 DPP4 0.0066
820 Glycine receptor subunit alpha-2 GLRA2 0.0066
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0065
4604 Liver carboxylesterase 1 CES1 0.0065
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0064
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0064
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0064
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0063
891 Dihydropteroate synthase folP 0.0062
5359 Dihydropteroate synthase folP 0.0062
7175 Dihydropteroate synthase sulI 0.0062
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0062
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0062
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0061
444 Alcohol dehydrogenase 1B ADH1B 0.0061
6143 Solute carrier family 22 member 7 SLC22A7 0.0061
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0061
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.006
734 D1 dopamine receptor-interacting protein calcyon CALY 0.006
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0059
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0059
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0059
1268 Neuropeptide S receptor NPSR1 0.0059
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0059
2129 Sucrase-isomaltase, intestinal SI 0.0055
6506 Stathmin-4 STMN4 0.0055
29 Tubulin beta-1 chain TUBB1 0.0055
380 Cytochrome P450 17A1 CYP17A1 0.0055
6073 Potassium channel subfamily K member 9 KCNK9 0.0054
6072 Potassium channel subfamily K member 3 KCNK3 0.0054
811 Translocator protein TSPO 0.0053
6148 Multidrug resistance-associated protein 7 ABCC10 0.0053
6020 Aldehyde oxidase AOX1 0.0053
517 Alcohol dehydrogenase 1C ADH1C 0.0053
6137 Multidrug resistance-associated protein 6 ABCC6 0.0052
756 Sex hormone-binding globulin SHBG 0.0052
1010 Cytochrome P450 51A1 CYP51A1 0.0052
844 Epidermal growth factor receptor EGFR 0.0051
856 Vitamin D3 receptor VDR 0.0051
2112 Toll-like receptor 9 TLR9 0.0051
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0051
3947 Xanthine dehydrogenase/oxidase XDH 0.0051
2981 Phospholipase A2, membrane associated PLA2G2A 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
80 Peroxisome proliferator-activated receptor alpha PPARA 0.005
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0049
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0049
173 Toll-like receptor 7 TLR7 0.0049
869 Estrogen receptor beta ESR2 0.0048
6136 Multidrug resistance-associated protein 5 ABCC5 0.0048
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0048
407 Vascular endothelial growth factor receptor 2 KDR 0.0047
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0047
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0047
3932 Glutathione S-transferase A2 GSTA2 0.0047
828 Phenylalanine-4-hydroxylase PAH 0.0047
3109 Phenylalanine-4-hydroxylase phhA 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
6014 Cytochrome P450 2A13 CYP2A13 0.0045
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0044
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0044
26 Vascular endothelial growth factor receptor 3 FLT4 0.0043
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0042
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0042
295 Carbonic anhydrase 1 CA1 0.0042
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0042
228 Beta platelet-derived growth factor receptor PDGFRB 0.0042
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0041
32 Vascular endothelial growth factor receptor 1 FLT1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
164 Histamine H4 receptor HRH4 0.004
2207 Rhodopsin RHO 0.0039
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
921 Glutamate receptor 2 GRIA2 0.0039
814 Ryanodine receptor 1 RYR1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0038
592 Carbonic anhydrase 4 CA4 0.0038
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0038
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0038
373 Transthyretin TTR 0.0038
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
581 Cytochrome P450 2R1 CYP2R1 0.0037
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0036
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
284 DNA-directed RNA polymerase beta chain rpoB 0.0035
5773 DNA-directed RNA polymerase beta chain rpoB 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
6138 Multidrug resistance protein 3 ABCB4 0.0034
563 Thyroid peroxidase TPO 0.0034
738 Monocarboxylate transporter 1 SLC16A1 0.0034
1024 Solute carrier family 22 member 11 SLC22A11 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0033
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0033
777 Tumor necrosis factor TNF 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1050 Bile salt sulfotransferase SULT2A1 0.0031
365 Dihydrofolate reductase DHFR 0.0031
2381 Dihydrofolate reductase DFR1 0.0031
2833 Dihydrofolate reductase Not Available 0.0031
2931 Dihydrofolate reductase folA 0.0031
3544 Dihydrofolate reductase folA 0.0031
3682 Dihydrofolate reductase folA 0.0031
6642 Dihydrofolate reductase folA 0.0031
6756 Dihydrofolate reductase dfrA 0.0031
1629 Transcription factor AP-1 JUN 0.0031
70 Type-1 angiotensin II receptor AGTR1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.003
6151 Monocarboxylate transporter 10 SLC16A10 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6102 Arylamine N-acetyltransferase 2 NAT2 0.003
4203 Histamine N-methyltransferase HNMT 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
1178 Adenosine A2a receptor ADORA2A 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
737 Mineralocorticoid receptor NR3C2 0.0029
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0028
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
84 Nuclear receptor 0B1 NR0B1 0.0026
7 Nitric oxide synthase, inducible NOS2 0.0026
49 Endothelin B receptor EDNRB 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0025
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
1992 Vitamin D-binding protein GC 0.0025
6141 Sodium/bile acid cotransporter SLC10A1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
165 FL cytokine receptor FLT3 0.0025
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0024
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0024
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
1630 Integrin beta-2 ITGB2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
5787 Angiopoietin-1 receptor TEK 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
4122 Histone deacetylase 2 HDAC2 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0022
3404 Exotoxin A eta 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0022
298 Renin REN 0.0021
16 Adenosine A1 receptor ADORA1 0.0021
275 Arachidonate 5-lipoxygenase ALOX5 0.0021
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
1192 Sulfotransferase 1A1 SULT1A1 0.0021
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0021
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
780 Retinoic acid receptor RXR-gamma RXRG 0.002
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
6126 Carbonic anhydrase 7 CA7 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
6085 Fatty acid-binding protein, intestinal FABP2 0.002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
518 Peroxidase/catalase T katG 0.0018
3937 Fatty-acid amide hydrolase FAAH 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
291 Nitric-oxide synthase, endothelial NOS3 0.0017
469 Annexin A1 ANXA1 0.0017
6146 High affinity copper uptake protein 1 SLC31A1 0.0017
4311 tRNA TRDMT1 0.0017
4325 tRNA trmD 0.0017
4328 tRNA trmD 0.0017
823 Fibroblast growth factor receptor 2 FGFR2 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4773 Deoxycytidine kinase DCK 0.0016
3426 Glutamine synthetase glnA 0.0016
3987 Glutamine synthetase GLUL 0.0016
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0016
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0016
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0016
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0016
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0016
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
5934 Cytochrome P450 26A1 CYP26A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
751 Potassium channel subfamily K member 6 KCNK6 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
735 Alanine aminotransferase 1 GPT 0.0015
3904 Alanine aminotransferase 2 GPT2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
922 Glutamate receptor 4 GRIA4 0.0015
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0015
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0015
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0015
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0015
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0015
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0015
4018 Glutamate receptor delta-2 subunit GRID2 0.0015
4027 Glutamate receptor delta-1 subunit GRID1 0.0015
1912 Excitatory amino acid transporter 1 SLC1A3 0.0015
4019 Excitatory amino acid transporter 4 SLC1A6 0.0015
4016 Excitatory amino acid transporter 5 SLC1A7 0.0015
4026 Aspartyl aminopeptidase DNPEP 0.0015
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0015
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0015
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0015
1047 Excitatory amino acid transporter 2 SLC1A2 0.0015
664 Glutamate decarboxylase 2 GAD2 0.0015
3890 Glutamate decarboxylase 2 GAD2 0.0015
4017 5-oxoprolinase OPLAH 0.0015
927 Metabotropic glutamate receptor 8 GRM8 0.0015
925 Metabotropic glutamate receptor 4 GRM4 0.0015
926 Metabotropic glutamate receptor 7 GRM7 0.0015
4020 Glutamyl aminopeptidase ENPEP 0.0015
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0015
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
6824 Tyrosine-protein kinase Lyn LYN 0.0014
1541 Metalloproteinase mmp20 0.0014
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1341 Histamine H3 receptor HRH3 0.0014
896 Glutathione S-transferase Mu 1 GSTM1 0.0014
183 Vascular endothelial growth factor A VEGFA 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0013
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
33 Cystine/glutamate transporter SLC7A11 0.0013
625 Glutamate carboxypeptidase 2 FOLH1 0.0013
153 Dopamine beta-hydroxylase DBH 0.0013
3809 Estrogen-related receptor gamma ESRRG 0.0013
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0013
5798 Mitogen-activated protein kinase 11 MAPK11 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
665 Phosphoserine aminotransferase PSAT1 0.0013
4652 Phosphoserine aminotransferase serC 0.0013
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0013
420 Glutamate decarboxylase 1 GAD1 0.0013
3900 Glutamate decarboxylase 1 GAD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0013
917 Glutaminase kidney isoform, mitochondrial GLS 0.0013
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0013
5 Glutaminase liver isoform, mitochondrial GLS2 0.0013
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0013
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0013
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0013
5261 Phosphoribosylformylglycinamidine synthase purL 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0013
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0013
569 Retinal dehydrogenase 2 ALDH1A2 0.0013
267 Plasminogen activator inhibitor 1 SERPINE1 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
923 Glutamate receptor 3 GRIA3 0.0012
1295 Fatty acid synthase FASN 0.0012
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0012
3877 Growth-inhibiting protein 18 GIG18 0.0012
763 Tyrosine aminotransferase TAT 0.0012
5493 Tyrosine aminotransferase Not Available 0.0012
1671 Excitatory amino acid transporter 3 SLC1A1 0.0012
6221 Steroid hormone receptor ERR1 ESRRA 0.0012
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0012
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
239 Coagulation factor X F10 0.0011
426 Aspartate aminotransferase, mitochondrial GOT2 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0011
1039 Histone deacetylase 9 HDAC9 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0011
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.001
54 Prothrombin F2 0.001
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
4103 Proteasome subunit beta type 2 PSMB2 0.001
4102 Proteasome subunit beta type 5 PSMB5 0.001
4101 Proteasome subunit beta type 1 PSMB1 0.001
976 Platelet glycoprotein IX GP9 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
76 Nitric-oxide synthase, brain NOS1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.001
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
511 5-hydroxytryptamine 1F receptor HTR1F 0.001
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.001
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
162 Retinoic acid receptor gamma-1 RARG 0.0009
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
6044 Serum paraoxonase/lactonase 3 PON3 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
2298 Cytochrome P450-cam camC 0.0008
1867 Major prion protein PRNP 0.0008
572 Integrin alpha-L ITGAL 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1864 RET proto-oncogene RET 0.0008
6163 Copper-transporting ATPase 2 ATP7B 0.0008
6165 Copper-transporting ATPase 1 ATP7A 0.0008
1025 Aquaporin-1 AQP1 0.0008
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0008
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
1275 Estrogen sulfotransferase SULT1E1 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
273 Apoptosis regulator Bcl-2 BCL2 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
3957 Adenosine deaminase ADA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0006
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4943 Cytochrome c6 petJ 0.0004
4984 Neuroglobin NGB 0.0004
3116 Bacterioferritin bfr 0.0004
4906 Bacterioferritin bfr 0.0004
4965 Bacterioferritin bfr 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4909 CooA protein cooA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4972 P450cin cinA 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4961 Hemophore HasA hasA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4952 Catalase/peroxidase katA 0.0004
3093 Catalase HPII katE 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
4920 Peroxidase/catalase katG 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
358 Cystathionine beta-synthase CBS 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
1507 Cytochrome c CYCS 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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