DT-Web: DB00357

Identification

Name

Aminoglutethimide

Accession Number

DB00357 (APRD00592)

Type

small molecule

Description

An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

232.2783

Groups

approved

Monoisotopic Weight

232.121177766

Pharmacology

Indication

For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.

Mechanism of action

Aminoglutethimide reduces the production of D5-pregnenolone and blocks several other steps in steroid synthesis, including the C-11, C-18, and C-21 hydroxylations and the hydroxylations required for the aromatization of androgens to estrogens, mediated through the binding of aminoglutethimide to cytochrome P-450 complexes. Specifically, the drug binds to and inhibits aromatase which is essential for the generation of estrogens from androstenedione and testosterone. A decrease in adrenal secretion of cortisol is followed by an increased secretion of pituitary adrenocorticotropic hormone (ACTH), which will overcome the blockade of adrenocortical steroid synthesis by aminoglutethimide. The compensatory increase in ACTH secretion can be suppressed by the simultaneous administration of hydrocortisone. Since aminoglutethimide increases the rate of metabolism of dexamethasone but not that of hydrocortisone, the latter is preferred as the adrenal glucocorticoid replacement. Although aminoglutethimide inhibits the synthesis of thyroxine by the thyroid gland, the compensatory increase in thyroid-stimulating hormone (TSH) is frequently of sufficient magnitude to overcome the inhibition of thyroid synthesis due to aminoglutethimide. In spite of an increase in TSH, aminoglutethimide has not been associated with increased prolactin secretion.

Absorption

Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.

Protein binding

21-25%

Biotransformation

Hepatic. 34-54% of the administered dose is excreted in the urine as unchanged drug during the first 48 hours, and an additional fraction as an N-acetyl derivative.

Route of elimination

After ingestion of a single oral dose, 34%-54% is excreted in the urine as unchanged drug during the first 48 hours, and an additional fraction as the N-acetyl derivative.

Toxicity

Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Aminoglutethimide may decrease the anticoagulant effect of acenocoumarol.
Anisindione	Aminoglutethimide may decrease the anticoagulant effect of anisindione.
Dexamethasone	Aminoglutethimide may decrease the effect of dexamethasone.
Dicumarol	Aminoglutethimide may decrease the anticoagulant effect of dicumarol.
Tamoxifen	Aminoglutethimide may increase Tamoxifen clearance decreasing its therapeutic effect. Consider alternate therapy or monitor for changes in Tamoxifen effects when Aminoglutethimide is initiated, discontinued or dose changed.
Telithromycin	Aminoglutethimide may decrease the plasma concentration of Telithromycin. Consider alternate therapy.
Temsirolimus	Aminoglutethimide may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Tramadol	Aminoglutethimide may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trazodone	The CYP3A4 inducer, Aminoglutethimide, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Aminoglutethimide is initiated, discontinued or dose changed.
Warfarin	Aminoglutethimide may decrease the anticoagulant effect of warfarin by increasing its metabolism. Monitor for changes in prothrombin time and therapeutic effects of warfarin if aminoglutethimide is initiated, discontinued or dose changed.

Food Interactions

Take without regard to meals.

Cytochrome P450 19A1
Name	Cytochrome P450 19A1
Gene Name	CYP19A1
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Greco F, Vicent MJ, Penning NA, Nicholson RI, Duncan R: HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines. J Drug Target. 2005 Sep-Nov;13(8-9):459-70. - Pubmed Martinez-Campa C, Gonzalez A, Mediavilla MD, Alonso-Gonzalez C, Sanchez-Barcelo EJ, Cos S: Melatonin enhances the inhibitory effect of aminoglutethimide on aromatase activity in MCF-7 human breast cancer cells. Breast Cancer Res Treat. 2005 Dec;94(3):249-54. Epub 2005 Oct 22. - Pubmed Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A: Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons. Br J Pharmacol. 2006 Apr;147(7):729-36. - Pubmed Siraki AG, Bonini MG, Jiang J, Ehrenshaft M, Mason RP: Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2007 Jul;20(7):1038-45. Epub 2007 Jun 30. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.3874
Cholesterol side-chain cleavage enzyme, mitochondrial
Name	Cholesterol side-chain cleavage enzyme, mitochondrial
Gene Name	CYP11A1
Pharmacological action	unknown
Actions	inhibitor
References	Slominski A, Semak I, Wortsman J, Zjawiony J, Li W, Zbytek B, Tuckey RC: An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS J. 2006 Jul;273(13):2891-901. - Pubmed Oka H, Emori Y, Hayashi Y, Nomoto K: Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma. Cell Immunol. 2000 Nov 25;206(1):7-15. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.1834

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inducer
References	- Santen RJ, Misbin RI: Aminoglutethimide: review of pharmacology and clinical use. Pharmacotherapy. 1981 Sep-Oct;1(2):95-120. - Pubmed BA Gross, SA Mindea, AJ Pick, JP Chandler, Batjer HH: Medical management of Cushing disease. Neurosurgical Focus. 2007 Sep;23(3). -
DTHybrid score	0.4727
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inducer
References	- Santen RJ, Misbin RI: Aminoglutethimide: review of pharmacology and clinical use. Pharmacotherapy. 1981 Sep-Oct;1(2):95-120. - Pubmed BA Gross, SA Mindea, AJ Pick, JP Chandler, Batjer HH: Medical management of Cushing disease. Neurosurgical Focus. 2007 Sep;23(3). -
DTHybrid score	0.3435
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inducer
References	- Santen RJ, Misbin RI: Aminoglutethimide: review of pharmacology and clinical use. Pharmacotherapy. 1981 Sep-Oct;1(2):95-120. - Pubmed BA Gross, SA Mindea, AJ Pick, JP Chandler, Batjer HH: Medical management of Cushing disease. Neurosurgical Focus. 2007 Sep;23(3). -
DTHybrid score	0.2962

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.2128
4119	Cytochrome P450 2D6	CYP2D6	0.1992
1588	Multidrug resistance protein 1	ABCB1	0.1643
4924	Cytochrome P450 2C8	CYP2C8	0.1402
4118	Cytochrome P450 3A5	CYP3A5	0.1228
6030	Cytochrome P450 2B6	CYP2B6	0.1162
6013	Cytochrome P450 2E1	CYP2E1	0.1138
6024	Cytochrome P450 1A1	CYP1A1	0.0959
6107	Cytochrome P450 3A7	CYP3A7	0.094
146	Androgen receptor	AR	0.0817
5718	Cytochrome P450 2A6	CYP2A6	0.0802
587	Serum albumin	ALB	0.0602
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0565
136	Estrogen receptor	ESR1	0.0559
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0496
756	Sex hormone-binding globulin	SHBG	0.0476
260	Cytochrome P450 51	ERG11	0.0475
761	Cytochrome P450 51	ERG11	0.0475
3163	Cytochrome P450 51	cyp51	0.0475
20	Prostaglandin G/H synthase 1	PTGS1	0.0474
1898	Cytochrome P450 1B1	CYP1B1	0.0386
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0383
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0376
6106	Cytochrome P450 2C18	CYP2C18	0.0368
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0341
492	Histamine H1 receptor	HRH1	0.0325
871	Glucocorticoid receptor	NR3C1	0.03
6145	Solute carrier family 22 member 1	SLC22A1	0.0299
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0293
3941	Amine oxidase [flavin-containing] A	MAOA	0.0286
824	Sodium-dependent serotonin transporter	SLC6A4	0.0278
380	Cytochrome P450 17A1	CYP17A1	0.0269
6142	Solute carrier family 22 member 8	SLC22A8	0.0267
1729	Solute carrier family 22 member 6	SLC22A6	0.0266
776	Bile salt export pump	ABCB11	0.0265
36	Insulin receptor	INSR	0.0258
290	Prostaglandin G/H synthase 2	PTGS2	0.0253
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0245
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0242
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0241
862	Multidrug resistance-associated protein 1	ABCC1	0.0239
563	Thyroid peroxidase	TPO	0.0236
556	Alpha-1A adrenergic receptor	ADRA1A	0.0232
6144	Solute carrier family 22 member 2	SLC22A2	0.0227
318	Alpha-2A adrenergic receptor	ADRA2A	0.0224
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0223
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0222
831	D(2) dopamine receptor	DRD2	0.0222
731	HIV-1 protease	HIV-1 protease	0.0221
4116	Dihydropteroate synthetase	Not Available	0.0209
3939	Amine oxidase [flavin-containing] B	MAOB	0.02
226	Gonadotropin-releasing hormone receptor	GNRHR	0.02
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0195
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.019
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0188
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0188
23	D(1A) dopamine receptor	DRD1	0.0187
6143	Solute carrier family 22 member 7	SLC22A7	0.0185
6031	Cytochrome P450 3A43	CYP3A43	0.0184
3923	Cholinesterase	BCHE	0.0182
614	Progesterone receptor	PGR	0.0175
148	Lutropin-choriogonadotropic hormone receptor	LHCGR	0.0175
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0174
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0173
847	Mu-type opioid receptor	OPRM1	0.017
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0169
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0169
629	Alpha-2B adrenergic receptor	ADRA2B	0.0169
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0165
634	Squalene monooxygenase	SQLE	0.0165
7196	Squalene monooxygenase	ERG1	0.0165
632	Alpha-1B adrenergic receptor	ADRA1B	0.0162
817	DNA topoisomerase 2-alpha	TOP2A	0.0161
713	Sodium-dependent dopamine transporter	SLC6A3	0.0161
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0159
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0158
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0157
6044	Serum paraoxonase/lactonase 3	PON3	0.0156
468	Cytochrome P450 4A11	CYP4A11	0.0155
766	Beta-2 adrenergic receptor	ADRB2	0.0155
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0152
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0148
477	DNA topoisomerase 4 subunit A	parC	0.0146
886	DNA topoisomerase 4 subunit A	parC	0.0146
6226	DNA topoisomerase 4 subunit A	parC	0.0146
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0146
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0146
404	DNA gyrase subunit A	gyrA	0.0144
6224	DNA gyrase subunit A	gyrA	0.0144
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0143
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0142
6182	Cytochrome P450 2J2	CYP2J2	0.0142
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0142
118	Organic cation/carnitine transporter 2	SLC22A5	0.0141
1010	Cytochrome P450 51A1	CYP51A1	0.0139
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0138
6167	Organic solute transporter subunit beta	OSTB	0.0137
6166	Organic solute transporter subunit alpha	OSTA	0.0137
193	Beta-1 adrenergic receptor	ADRB1	0.0134
2164	Multidrug resistance-associated protein 4	ABCC4	0.0134
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0134
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0133
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0133
869	Estrogen receptor beta	ESR2	0.0128
789	Alpha-1D adrenergic receptor	ADRA1D	0.0128
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0127
6014	Cytochrome P450 2A13	CYP2A13	0.0127
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0127
1656	CYP2B protein	CYP2B	0.0125
833	Organic cation/carnitine transporter 1	SLC22A4	0.0124
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0123
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0122
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0121
6147	Solute carrier family 22 member 3	SLC22A3	0.0119
467	Delta-type opioid receptor	OPRD1	0.0117
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0116
638	D(3) dopamine receptor	DRD3	0.0115
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0114
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0114
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0111
1178	Adenosine A2a receptor	ADORA2A	0.0109
3947	Xanthine dehydrogenase/oxidase	XDH	0.0109
581	Cytochrome P450 2R1	CYP2R1	0.0109
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0107
5934	Cytochrome P450 26A1	CYP26A1	0.0106
465	Calmodulin	CALM1	0.0104
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0104
3957	Adenosine deaminase	ADA	0.0104
6020	Aldehyde oxidase	AOX1	0.0103
818	50S ribosomal protein L10	rplJ	0.0102
378	Alpha-2C adrenergic receptor	ADRA2C	0.0101
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.01
856	Vitamin D3 receptor	VDR	0.01
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0099
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0099
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0097
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0097
1024	Solute carrier family 22 member 11	SLC22A11	0.0094
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0093
777	Tumor necrosis factor	TNF	0.0093
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0093
122	P2Y purinoceptor 12	P2RY12	0.0092
1992	Vitamin D-binding protein	GC	0.0091
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0091
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0088
696	Kappa-type opioid receptor	OPRK1	0.0088
432	D(4) dopamine receptor	DRD4	0.0087
844	Epidermal growth factor receptor	EGFR	0.0087
6136	Multidrug resistance-associated protein 5	ABCC5	0.0087
6220	Aryl hydrocarbon receptor	AHR	0.0086
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0086
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0085
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0083
474	Acetylcholinesterase	ACHE	0.0082
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0082
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
6148	Multidrug resistance-associated protein 7	ABCC10	0.008
6141	Sodium/bile acid cotransporter	SLC10A1	0.0079
16	Adenosine A1 receptor	ADORA1	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0078
373	Transthyretin	TTR	0.0078
124	Histamine H2 receptor	HRH2	0.0077
1757	Myeloperoxidase	MPO	0.0076
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0075
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0075
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0075
84	Nuclear receptor 0B1	NR0B1	0.0071
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0071
1649	Small inducible cytokine A2	CCL2	0.007
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0069
469	Annexin A1	ANXA1	0.0069
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0067
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0067
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0067
273	Apoptosis regulator Bcl-2	BCL2	0.0066
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0066
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0066
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0066
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0065
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0065
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0065
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0065
780	Retinoic acid receptor RXR-gamma	RXRG	0.0065
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0064
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0064
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0064
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0064
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0064
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0064
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
716	5-hydroxytryptamine 7 receptor	HTR7	0.0063
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0063
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0062
26	Vascular endothelial growth factor receptor 3	FLT4	0.0062
4604	Liver carboxylesterase 1	CES1	0.0062
564	Cellular retinoic acid-binding protein 1	CRABP1	0.006
29	Tubulin beta-1 chain	TUBB1	0.006
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0059
32	Vascular endothelial growth factor receptor 1	FLT1	0.0059
70	Type-1 angiotensin II receptor	AGTR1	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
88	Retinoic acid receptor RXR-beta	RXRB	0.0059
163	D(1B) dopamine receptor	DRD5	0.0059
3809	Estrogen-related receptor gamma	ESRRG	0.0059
7	Nitric oxide synthase, inducible	NOS2	0.0059
407	Vascular endothelial growth factor receptor 2	KDR	0.0059
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0058
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0058
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0058
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0057
459	Retinoic acid receptor RXR-alpha	RXRA	0.0057
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0056
144	Hemoglobin subunit alpha	HBA1	0.0056
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0055
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0055
592	Carbonic anhydrase 4	CA4	0.0055
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0055
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0055
811	Translocator protein	TSPO	0.0055
161	Tubulin beta chain	TUBB	0.0054
312	Tubulin beta chain	TUB2	0.0054
5998	Toll-like receptor 8	TLR8	0.0053
504	Mast/stem cell growth factor receptor	KIT	0.0053
229	Retinoic acid receptor beta	RARB	0.0052
49	Endothelin B receptor	EDNRB	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
4122	Histone deacetylase 2	HDAC2	0.0052
712	Tubulin alpha chain	TUB1	0.0052
284	DNA-directed RNA polymerase beta chain	rpoB	0.0052
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0052
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0051
730	Retinoic acid receptor alpha	RARA	0.0051
3830	Calreticulin	CALR	0.0051
6137	Multidrug resistance-associated protein 6	ABCC6	0.0051
921	Glutamate receptor 2	GRIA2	0.005
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.005
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.005
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.005
578	Endothelin-1 receptor	EDNRA	0.0049
162	Retinoic acid receptor gamma-1	RARG	0.0049
6102	Arylamine N-acetyltransferase 2	NAT2	0.0049
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0049
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0048
427	Substance-P receptor	TACR1	0.0048
68	Cannabinoid receptor 1	CNR1	0.0048
6034	Hydroxyindole O-methyltransferase	ASMT	0.0048
6035	Nuclear receptor ROR-beta	RORB	0.0048
6036	Eosinophil peroxidase	EPX	0.0048
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0046
173	Toll-like receptor 7	TLR7	0.0046
4237	50S ribosomal protein L22	rplV	0.0046
6043	Putative G-protein coupled receptor 44	GPR44	0.0045
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0043
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0043
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0043
952	Dipeptidyl peptidase 4	DPP4	0.0043
2539	Tubulin alpha-1 chain	TUBA4A	0.0043
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0043
3810	Catechol O-methyltransferase	COMT	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
4120	NADPH--cytochrome P450 reductase	POR	0.0042
765	Indoleamine 2,3-dioxygenase	IDO1	0.0042
94	5-hydroxytryptamine 4 receptor	HTR4	0.0042
357	Carbonic anhydrase 2	CA2	0.0041
295	Carbonic anhydrase 1	CA1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
1517	Beta-3 adrenergic receptor	ADRB3	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
814	Ryanodine receptor 1	RYR1	0.004
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.004
1129	C-C chemokine receptor type 5	CCR5	0.0039
6432	Transporter	snf	0.0039
1852	Microtubule-associated protein 2	MAP2	0.0039
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0038
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0038
183	Vascular endothelial growth factor A	VEGFA	0.0038
1192	Sulfotransferase 1A1	SULT1A1	0.0038
85	Growth hormone receptor	GHR	0.0038
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0037
2782	Complement C1s subcomponent	C1S	0.0037
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0036
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0036
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0036
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0036
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0036
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0036
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0036
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0036
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0036
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0036
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
185	Vasopressin V1a receptor	AVPR1A	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
275	Arachidonate 5-lipoxygenase	ALOX5	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0034
3815	Complement C1q subcomponent subunit A	C1QA	0.0034
3816	Complement C1q subcomponent subunit B	C1QB	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
3817	Complement C1q subcomponent subunit C	C1QC	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0034
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0034
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0034
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0034
3814	Complement C1r subcomponent	C1R	0.0034
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0034
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0034
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.0034
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0032
267	Plasminogen activator inhibitor 1	SERPINE1	0.0032
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0032
4311	tRNA	TRDMT1	0.0032
4325	tRNA	trmD	0.0032
4328	tRNA	trmD	0.0032
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0032
904	Glutathione S-transferase P	GSTP1	0.0032
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0032
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0032
518	Peroxidase/catalase T	katG	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
5923	Microtubule-associated protein tau	MAPT	0.0031
5924	Microtubule-associated protein 4	MAP4	0.0031
705	Glutamate receptor 1	GRIA1	0.0031
5300	Antigen peptide transporter 1	TAP1	0.0031
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
737	Mineralocorticoid receptor	NR3C2	0.003
543	Penicillin-binding protein 1B	mrcB	0.003
6186	Penicillin-binding protein 1B	ponB	0.003
6822	Penicillin-binding protein 1b	pbp1b	0.003
6844	Penicillin-binding protein 1b	pbp1b	0.003
823	Fibroblast growth factor receptor 2	FGFR2	0.003
365	Dihydrofolate reductase	DHFR	0.003
2381	Dihydrofolate reductase	DFR1	0.003
2833	Dihydrofolate reductase	Not Available	0.003
2931	Dihydrofolate reductase	folA	0.003
3544	Dihydrofolate reductase	folA	0.003
3682	Dihydrofolate reductase	folA	0.003
6642	Dihydrofolate reductase	folA	0.003
6756	Dihydrofolate reductase	dfrA	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
6221	Steroid hormone receptor ERR1	ESRRA	0.003
239	Coagulation factor X	F10	0.0029
159	Penicillin-binding protein 2B	penA	0.0029
6121	Penicillin-binding protein 2B	penA	0.0029
482	Glycine receptor subunit alpha-1	GLRA1	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
891	Dihydropteroate synthase	folP	0.0029
5359	Dihydropteroate synthase	folP	0.0029
7175	Dihydropteroate synthase	sulI	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
1618	High affinity nerve growth factor receptor	NTRK1	0.0028
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0028
33	Cystine/glutamate transporter	SLC7A11	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
1629	Transcription factor AP-1	JUN	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0026
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
1648	Elastin	ELN	0.0026
6126	Carbonic anhydrase 7	CA7	0.0026
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0026
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0026
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0025
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0024
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6146	High affinity copper uptake protein 1	SLC31A1	0.0024
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0023
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0022
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0022
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0022
1050	Bile salt sulfotransferase	SULT2A1	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0021
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
976	Platelet glycoprotein IX	GP9	0.002
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.002
153	Dopamine beta-hydroxylase	DBH	0.002
4103	Proteasome subunit beta type 2	PSMB2	0.002
4102	Proteasome subunit beta type 5	PSMB5	0.002
4101	Proteasome subunit beta type 1	PSMB1	0.002
1820	Beta-nerve growth factor	NGF	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
106	Cannabinoid receptor 2	CNR2	0.002
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.002
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.002
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0019
3932	Glutathione S-transferase A2	GSTA2	0.0019
6174	50S ribosomal protein L32	rpmF	0.0019
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0019
291	Nitric-oxide synthase, endothelial	NOS3	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
1196	Complement decay-accelerating factor	CD55	0.0019
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0018
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0018
558	Solute carrier family 12 member 1	SLC12A1	0.0018
165	FL cytokine receptor	FLT3	0.0018
1253	Interferon gamma	IFNG	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
251	Alcohol dehydrogenase 1A	ADH1A	0.0018
683	Potassium transporter	GK0582	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0017
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0017
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0017
6085	Fatty acid-binding protein, intestinal	FABP2	0.0017
820	Glycine receptor subunit alpha-2	GLRA2	0.0017
936	Ephrin type-A receptor 2	EPHA2	0.0017
4192	DNA topoisomerase 2-beta	TOP2B	0.0017
2808	Chloramphenicol acetyltransferase 3	cat3	0.0016
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
738	Monocarboxylate transporter 1	SLC16A1	0.0016
3937	Fatty-acid amide hydrolase	FAAH	0.0016
1243	Cathepsin D	CTSD	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
444	Alcohol dehydrogenase 1B	ADH1B	0.0016
5787	Angiopoietin-1 receptor	TEK	0.0016
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0015
3233	Bile acid receptor	NR1H4	0.0015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0015
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0015
3856	Fibroblast growth factor receptor 3	FGFR3	0.0015
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0015
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0015
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0015
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0015
3601	Dihydropteroate synthase 1	folP1	0.0015
3807	Dihydropteroate synthase 1	folP1	0.0015
3808	Dihydropteroate synthase 2	folP2	0.0015
2417	Chloramphenicol acetyltransferase	cat	0.0015
3278	Chloramphenicol acetyltransferase	cat	0.0015
2810	Dr hemagglutinin structural subunit	draA	0.0015
1714	Mitogen-activated protein kinase 3	MAPK3	0.0015
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
1864	RET proto-oncogene	RET	0.0015
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0015
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0015
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0015
1541	Metalloproteinase	mmp20	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0014
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0014
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0014
65	Matrix metalloproteinase-9	Not Available	0.0014
6859	Protein S100-A4	S100A4	0.0014
517	Alcohol dehydrogenase 1C	ADH1C	0.0014
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0014
2300	Lysozyme	E	0.0014
3633	Lysozyme	R	0.0014
5597	Lysozyme	17	0.0014
6149	Solute carrier family 22 member 10	SLC22A10	0.0014
54	Prothrombin	F2	0.0013
319	Opioid receptor, sigma 1	OPRS1	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
1039	Histone deacetylase 9	HDAC9	0.0013
164	Histamine H4 receptor	HRH4	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0013
908	Glutathione S-transferase theta-1	GSTT1	0.0013
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
1630	Integrin beta-2	ITGB2	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
896	Glutathione S-transferase Mu 1	GSTM1	0.0012
4217	Telomerase reverse transcriptase	TERT	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0012
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0012
1374	Natriuretic peptides B	NPPB	0.0012
1827	Gap junction alpha-1 protein	GJA1	0.0012
1908	Vascular cell adhesion protein 1	VCAM1	0.0012
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0011
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0011
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0011
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0011
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0011
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0011
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
174	Sigma 1-type opioid receptor	SIGMAR1	0.0011
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0011
24	Thymidylate synthase	TMP1	0.0011
359	Thymidylate synthase	TYMS	0.0011
2626	Thymidylate synthase	thyA	0.0011
2729	Thymidylate synthase	thyA	0.0011
5352	Thymidylate synthase	THYA	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.001
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.001
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.001
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.001
268	Adenosine A2b receptor	ADORA2B	0.001
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.001
3868	Calcineurin subunit B isoform 2	PPP3R2	0.001
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.001
572	Integrin alpha-L	ITGAL	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0009
5798	Mitogen-activated protein kinase 11	MAPK11	0.0009
4773	Deoxycytidine kinase	DCK	0.0009
2320	Thymidine kinase, cytosolic	TK1	0.0009
484	Tyrosine-protein kinase ABL2	ABL2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
6218	Pannexin-1	PANX1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
760	Fibroblast growth factor 1	FGF1	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0008
751	Potassium channel subfamily K member 6	KCNK6	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0007
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
822	Aldose reductase	AKR1B1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
172	Potassium channel subfamily K member 1	KCNK1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2298	Cytochrome P450-cam	camC	0.0007
2021	Thrombomodulin	THBD	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
125	DNA polymerase beta	POLB	0.0007
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
6163	Copper-transporting ATPase 2	ATP7B	0.0006
6165	Copper-transporting ATPase 1	ATP7A	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0005
489	Monocarboxylate transporter 2	SLC16A7	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
798	Osteocalcin	BGLAP	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
6042	Prostaglandin reductase 2	PTGR2	0.0005
369	Coagulation factor VII	F7	0.0005
1792	Tissue-type plasminogen activator	PLAT	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
1313	Lactoylglutathione lyase	GLO1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
2207	Rhodopsin	RHO	0.0002
76	Nitric-oxide synthase, brain	NOS1	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00357 - Aminoglutethimide

Targets

Enzymes

Predictions