DT-Web

DB00266 - Dicumarol


Identification
Name Dicumarol
Accession Number DB00266 (APRD00761)
Type small molecule
Description An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 336.295
Groups approved
Monoisotopic Weight 336.063388116
Pharmacology
Indication For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis.
Mechanism of action Dicumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity LD50=233 mg/kg (orally in mice); LD50=250 mg/kg (orally in rats)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetaminophen Acetaminophen may increase the anticoagulant effect of dicumarol. Monitor for changes in the therapeutic and adverse effects of dicumarol if acetaminophen is initiated, discontinued or dose changed.
Acetohexamide Dicumarol may increase the effect of sulfonylurea, acetohexamide.
Acetylsalicylic acid Acetylsalicylic acid increases effect of the anticoagulant, dicumarol.
Allopurinol Allopurinol may increase the anticoagulant effect of dicumarol.
Aminoglutethimide Aminoglutethimide may decrease the anticoagulant effect of dicumarol.
Amiodarone Amiodarone may increase the anticoagulant effect of dicumarol.
Amprenavir Amprenavir may increase the anticoagulant effect of dicumarol by increasing its serum concentration.
Aprepitant Aprepitant may decrease the anticoagulant effect of dicumarol by decreasing its serum concentration.
Atazanavir The protease inhibitor, atazanavir, may increase the anticoagulant effect of dicumarol.
Azathioprine Azathioprine may decrease the anticoagulant effect of dicumarol.
Azithromycin Azithromycin may increase the anticoagulant effect of dicumarol by increasing its serum concentration.
Betamethasone The corticosteroid, betamethasone, alters the anticoagulant effect of dicumarol.
Bosentan Bosentan may decrease the anticoagulant effect of dicumarol by increasing its metabolism.
Capecitabine Capecitabine may increase the anticoagulant effect of dicumarol by increasing its serum concentration.
Carbamazepine Carbamazepine may decrease the anticoagulant effect of dicumarol by decreasing its serum concentration.
Cefotetan The cephalosporin, cefotetan, may increase the anticoagulant effect of dicumarol.
Cefoxitin The cephalosporin, cefoxitin, may increase the anticoagulant effect of dicumarol.
Ceftriaxone The cephalosporin, ceftriaxone, may increase the anticoagulant effect of dicumarol.
Celecoxib Celecoxib may increase the anticoagulant effect of dicumarol.
Chlorpropamide Dicumarol may increase the effect of sulfonylurea, chlorpropamide.
Cholestyramine The bile acid sequestrant, cholestyramine, may decrease the anticoagulant effect of dicumarol by decreasing its absorption.
Cimetidine Cimetidine may increase the anticoagulant effect of dicumarol.
Ciprofloxacin The quinolone antibiotic, ciprofloxacin, may increase the anticoagulant effect of dicumarol.
Cisapride Cisapride may increase the anticoagulant effect of dicumarol.
Citalopram The SSRI, citalopram, increases the effect of anticoagulant, dicumarol.
Clarithromycin The macrolide, clarithromycin, may increase the anticoagulant effect of dicumarol.
Clofibrate The fibrate increases the anticoagulant effect
Colestipol The bile acid sequestrant, colestipol, may decrease the anticoagulant effect of dicumarol by decreasing its absorption.
Cyclophosphamide The antineoplastic agent, cyclophosphamide may alter the anticoagulant effect of dicumarol.
Danazol The androgen, danazol, may increase the anticoagulant effect of dicumarol.
Demeclocycline The tetracycline, demeclocycline, may increase the anticoagulant effect of dicumarol.
Dexamethasone The corticosteroid, dexamethasone, alters the anticoagulant effect of dicumarol.
Dextrothyroxine The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of dicumarol.
Diclofenac The NSAID, diclofenac, may increase the anticoagulant effect of dicumarol.
Dicloxacillin Dicloxacillin may decrease the anticoagulant effect of dicumarol.
Diflunisal The NSAID, diflunisal, may increase the anticoagulant effect of dicumarol.
Disulfiram Disulfiram may increase the anticoagulant effect of dicumarol.
Doxycycline The tetracycline, doxycycline, may increase the anticoagulant effect of dicumarol.
Erythromycin The macrolide, erythromycin, may increase the anticoagulant effect of dicumarol..
Ethchlorvynol Ethchlorvynol may decrease the anticoagulant effect of dicumarol.
Ethinyl Estradiol Increased thrombotic risk due to estrogen
Etodolac The NSAID, etodolac, may increase the anticoagulant effect of dicumarol.
Etoricoxib Etoricoxib may increase the anticoagulant effect of dicumarol.
Fenofibrate Fenofibrate may increase the anticoagulant effect of dicumarol.
Fenoprofen The NSAID, fenoprofen, may increase the anticoagulant effect of dicumarol.
Fluconazole Fluconazole may increase the serum concentration of dicumarol by decreasing its metabolism.
Fludrocortisone The corticosteroid, fludrocortisone, alters the anticoagulant effect of dicumarol.
Fluorouracil The antineoplasic agent, fluorouracil, may increase the anticoagulant effect of dicumarol.
Fluoxetine The SSRI, fluoxetine, increases the effect of anticoagulant, dicumarol.
Fluoxymesterone The androgen, fluoxymesterone, may increase the anticoagulant effect of dicumarol.
Flurbiprofen The NSAID, flurbiprofen, may increase the anticoagulant effect of dicumarol.
Fluvastatin Fluvastatin may increase the anticoagulant effect of dicumarol. Monitor for changes in the therapeutic and adverse effects of dicumarol if fluvastatin if initiated, discontinued or dose changed.
Fluvoxamine Fluvoxamine may increase the anticoagulant effect of dicumarol by increasing its serum concentration.
Fosamprenavir The protease inhibitor, fosamprenavir, may increase the anticoagulant effect of dicumarol.
Fosphenytoin Increased hydantoin levels and risk of bleeding
Gefitinib Gefitinib may increase the anticoagulant effect of dicumarol.
Gemcitabine Gemcitabine may increase the anticoagulant effect of dicumarol.
Gemfibrozil Gemfibrozil may increase the anticoagulant effect of dicumarol.
Gliclazide Dicumarol may increase the effect of sulfonylurea, gliclazide.
Glutethimide Glutethimide may decrease the anticoagulant effect of dicumarol.
Glyburide Dicumarol may increase the effect of sulfonylurea, glibenclamide.
Griseofulvin Griseofulvin may decrease the anticoagulant effect of dicumarol.
Hydrocortisone The corticosteroid, hydrocortisone, alters the anticoagulant effect of dicumarol.
Ibuprofen The NSAID, ibuprofen, may increase the anticoagulant effect of dicumarol.
Imatinib Imatinib may increase the anticoagulant effect of dicumarol.
Indinavir The protease inhibitor, indinavir, may increase the anticoagulant effect of dicumarol.
Indomethacin The NSAID, indomethacin, may increase the anticoagulant effect of dicumarol.
Isoniazid Isoniazid may increase the anticoagulant effect of dicumarol.
Itraconazole Itraconazole may increase the anticoagulant effect of dicumarol.
Ketoconazole Ketoconazole may increase the anticoagulant effect of dicumarol.
Ketoprofen The NSAID, ketoprofen, may increase the anticoagulant effect of dicumarol.
Ketorolac The NSAID, ketorolac, may increase the anticoagulant effect of dicumarol.
Leflunomide Leflunomide may increase the anticoagulant effect of dicumarol.
Levamisole Levamisole may increase the anticoagulant effect of dicumarol.
Levofloxacin The quinolone antibiotic, levofloxacin, may increase the anticoagulant effect of dicumarol.
Levothyroxine The thyroid hormone, levothyroxine, increase the anticoagulant effect of dicumarol.
Lovastatin Lovastatin may increase the anticoagulant effect dicumarol. Monitor for changes in the therapeutic and adverse effects of dicumarol if lovastatin is initiated, discontinued or dose changed.
Lumiracoxib Lumiracoxib may increase the anticoagulant effect of dicumarol.
Medroxyprogesterone Medroxyprogesterone may increase the anticoagulant effect of dicumarol.
Mefenamic acid The NSAID, mefanamic acid, may increase the anticoagulant effect of dicumarol.
Mefloquine Mefloquine may increase the anticoagulant effect of dicumarol.
Meloxicam Meloxicam may increase the anticoagulant effect of dicumarol.
Mercaptopurine Mercaptopurine may decrease the anticoagulant effect of dicumarol.
Methimazole The antithyroid agent, methimazole, may decrease the anticoagulant effect of dicumarol.
Metronidazole Metronidazole may increase the anticoagulant effect of dicumarol.
Miconazole Miconazole may increase the serum concentration of dicumarol by decreasing its metabolism.
Minocycline The tetracycline, minocycline, may increase the anticoagulant effect of dicumarol.
Mitotane Mitotane may decrease the anticoagulant effect of dicumarol.
Moxifloxacin The quinolone antibiotic, moxifloxacin, may increase the anticoagulant effect of dicumarol.
Nabumetone The NSAID, nabumetone, may increase the anticoagulant effect of dicumarol.
Nalidixic Acid The quinolone antibiotic, nalidixic acid, may increase the anticoagulant effect of dicumarol.
Naproxen The NSAID, naproxen, may increase the anticoagulant effect of dicumarol.
Nelfinavir The protease inhibitor, nelfinavir, may increase the anticoagulant effect of dicumarol.
Nevirapine Nevirapine may decrease the anticoagulant effect of dicumarol.
Norfloxacin The quinolone antibiotic, norfloxacin, may increase the anticoagulant effect of dicumarol.
Ofloxacin The quinolone antibiotic, ofloxacin, may increase the anticoagulant effect of dicumarol.
Orlistat Orlistat may increase the anticoagulant effect of dicumarol.
Oxaprozin The NSAID, oxaprozin, may increase the anticoagulant effect of dicumarol.
Oxyphenbutazone The NSAID, oxyphenbutazone, may increase the anticoagulant effect of dicumarol.
Paroxetine The SSRI, paroxetine, increases the effect of anticoagulant, dicumarol.
Pentoxifylline Pentoxifylline may increase the anticoagulant effect of dicumarol.
Phenobarbital The barbiturate, phenobarbital, decreases the anticoagulant effect, dicumarol.
Phenylbutazone The NSAID, phenylbutazone, may increase the anticoagulant effect of dicumarol.
Phenytoin Increased hydantoin levels and risk of bleeding
Piroxicam The NSAID, piroxicam, may increase the anticoagulant effect of dicumarol.
Prednisolone The corticosteroid, prednisolone, alters the anticoagulant effect of dicumarol.
Prednisone The corticosteroid, prednisone, alters the anticoagulant effect of dicumarol.
Primidone The barbiturate, primidone, decreases the anticoagulant effect, dicumarol.
Propafenone Propafenone may increase the anticoagulant effect of dicumarol.
Propoxyphene Propoxyphene may increase the anticoagulant effect of dicumarol.
Propylthiouracil The anti-thyroid agent, propylthiouracil, may decrease the anticoagulant effect of dicumarol.
Quinidine Quinidine may increase the anticoagulant effect of dicumarol.
Quinine Quinine may increase the anticoagulant effect of dicumarol.
Ranitidine Ranitidine may increase the anticoagulant effect of dicumarol. (Conflicting evidence)
Rifabutin Rifabutin may decrease the anticoagulant effect of dicumarol.
Rifampin Rifampin may decrease the anticoagulant effect of dicumarol.
Telithromycin Telithromycin may increase the anticoagulant effect of dicumarol.
Tenoxicam The NSAID, tenoxicam, may increase the anticoagulant effect of dicumarol.
Testosterone The androgen may increase the anticoagulant effect of dicumarol.
Tetracycline Tetracycline may increase the anticoagulant effect of dicumarol.
Tigecycline Tigecycline may increase the anticoagulant effect of dicumarol.
Triamcinolone The corticosteroid, triamcinolone, alters the anticoagulant effect of dicumarol.
Food Interactions Not Available

Targets


Vitamin K epoxide reductase complex subunit 1
Name Vitamin K epoxide reductase complex subunit 1
Gene Name VKORC1
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Wallin R, Patrick SD, Ballard JO: Vitamin K antagonism of coumarin intoxication in the rat. Thromb Haemost. 1986 Apr 30;55(2):235-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6229
NAD(P)H dehydrogenase [quinone] 1
Name NAD(P)H dehydrogenase [quinone] 1
Gene Name NQO1
Pharmacological action unknown
Actions inhibitor
References
  • Chen S, Wu K, Zhang D, Sherman M, Knox R, Yang CS: Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling. Mol Pharmacol. 1999 Aug;56(2):272-8. - Pubmed
  • Jaiswal AK: Characterization and partial purification of microsomal NAD(P)H:quinone oxidoreductases. Arch Biochem Biophys. 2000 Mar 1;375(1):62-8. - Pubmed
  • Joseph P, Jaiswal AK: A unique cytosolic activity related but distinct from NQO1 catalyses metabolic activation of mitomycin C. Br J Cancer. 2000 Apr;82(7):1305-11. - Pubmed
  • Floreani M, Napoli E, Palatini P: Protective action of cardiac DT-diaphorase against menadione toxicity in guinea pig isolated atria. Biochem Pharmacol. 2000 Aug 15;60(4):601-5. - Pubmed
  • Arriagada C, Dagnino-Subiabre A, Caviedes P, Armero JM, Caviedes R, Segura-Aguilar J: Studies of aminochrome toxicity in a mouse derived neuronal cell line: is this toxicity mediated via glutamate transmission? Amino Acids. 2000;18(4):363-73. - Pubmed
  • Preusch PC, Smalley DM: Vitamin K1 2,3-epoxide and quinone reduction: mechanism and inhibition. Free Radic Res Commun. 1990;8(4-6):401-15. - Pubmed
DTHybrid score 0.8816
Quinone oxidoreductase
Name Quinone oxidoreductase
Gene Name CRYZ
Pharmacological action unknown
Actions inhibitor
References
  • Evans PJ: Decreased intracellular proteolysis correlates with the maintenance of a specific isoenzyme of cytochrome P-450. Cell Biol Int. 1999;23(2):117-24. - Pubmed
  • Audi SH, Bongard RD, Dawson CA, Siegel D, Roerig DL, Merker MP: Duroquinone reduction during passage through the pulmonary circulation. Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1116-31. Epub 2003 Jul 25. - Pubmed
  • Asher G, Dym O, Tsvetkov P, Adler J, Shaul Y: The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol. Biochemistry. 2006 May 23;45(20):6372-8. - Pubmed
  • Maser E, Gebel T, Netter KJ: Carbonyl reduction of metyrapone in human liver. Biochem Pharmacol. 1991 Dec 11;42 Suppl:S93-8. - Pubmed
  • Hao H, Wang G, Cui N, Li J, Xie L, Ding Z: Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation. Curr Drug Metab. 2007 Feb;8(2):137-49. - Pubmed
DTHybrid score 0.3178

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3065

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.0999
6016 Cytochrome P450 2C19 CYP2C19 0.0937
4924 Cytochrome P450 2C8 CYP2C8 0.0864
4200 Cytochrome P450 1A2 CYP1A2 0.0744
587 Serum albumin ALB 0.0607
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0602
904 Glutathione S-transferase P GSTP1 0.0547
4119 Cytochrome P450 2D6 CYP2D6 0.051
4407 FMN-dependent NADH-azoreductase azoR 0.045
5169 FMN-dependent NADH-azoreductase azoR 0.045
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
6013 Cytochrome P450 2E1 CYP2E1 0.036
6024 Cytochrome P450 1A1 CYP1A1 0.0356
6030 Cytochrome P450 2B6 CYP2B6 0.0335
20 Prostaglandin G/H synthase 1 PTGS1 0.0322
1588 Multidrug resistance protein 1 ABCB1 0.0312
5718 Cytochrome P450 2A6 CYP2A6 0.0278
4118 Cytochrome P450 3A5 CYP3A5 0.0263
6106 Cytochrome P450 2C18 CYP2C18 0.0254
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0245
3947 Xanthine dehydrogenase/oxidase XDH 0.0223
400 Coagulation factor IX F9 0.0222
5461 Coagulation factor IX F9 0.0222
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0215
604 Vitamin K-dependent protein Z PROZ 0.0214
290 Prostaglandin G/H synthase 2 PTGS2 0.0212
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0209
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0203
6107 Cytochrome P450 3A7 CYP3A7 0.0197
422 Vitamin K-dependent protein C PROC 0.0183
1245 Vitamin K-dependent protein S PROS1 0.0183
6163 Copper-transporting ATPase 2 ATP7B 0.0168
6165 Copper-transporting ATPase 1 ATP7A 0.0168
6146 High affinity copper uptake protein 1 SLC31A1 0.0165
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0162
798 Osteocalcin BGLAP 0.0152
908 Glutathione S-transferase theta-1 GSTT1 0.015
1757 Myeloperoxidase MPO 0.0149
896 Glutathione S-transferase Mu 1 GSTM1 0.0147
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0138
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0137
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0136
369 Coagulation factor VII F7 0.0136
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0136
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0136
5332 MtdA bifunctional protein mtdA 0.0136
4403 Protein iolS iolS 0.0136
5330 General stress protein 69 yhdN 0.0136
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0136
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0136
3778 NAD(P) transhydrogenase subunit beta pntB 0.0136
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0136
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0136
5322 Oxidoreductase ydhF ydhF 0.0136
5073 Ferredoxin--NADP reductase petH 0.0135
5076 Ferredoxin--NADP reductase fpr 0.0135
5119 Ferredoxin--NADP reductase petH 0.0135
5121 Ferredoxin--NADP reductase fpr 0.0135
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0135
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0133
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0129
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0125
3917 Methylenetetrahydrofolate reductase MTHFR 0.0125
4120 NADPH--cytochrome P450 reductase POR 0.0124
4582 Putative pteridine reductase 2 ptr2 0.0118
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0118
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0118
2636 Shikimate dehydrogenase aroE 0.0118
3515 Shikimate dehydrogenase aroE 0.0118
3446 NADP-dependent alcohol dehydrogenase adh 0.0117
5328 Prostaglandin F synthase Tb11.02.2310 0.0117
989 L-xylulose reductase DCXR 0.0117
729 GDP-L-fucose synthetase TSTA3 0.0117
3463 GDP-L-fucose synthetase fcl 0.0117
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0117
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0117
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0117
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0117
2286 Isocitrate dehydrogenase [NADP] icd 0.0117
2302 Isocitrate dehydrogenase [NADP] icd 0.0117
2771 Isocitrate dehydrogenase [NADP] icd 0.0117
1898 Cytochrome P450 1B1 CYP1B1 0.0114
646 Malate dehydrogenase, cytoplasmic MDH1 0.0114
6020 Aldehyde oxidase AOX1 0.0112
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0112
666 NADP-dependent malic enzyme ME1 0.0112
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0111
76 Nitric-oxide synthase, brain NOS1 0.0111
54 Prothrombin F2 0.0111
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.011
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.011
6297 Prostaglandin reductase 1 PTGR1 0.0109
4531 Putative ketoacyl reductase actIII 0.0109
3062 Aspartate-semialdehyde dehydrogenase asd 0.0108
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0107
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0107
239 Coagulation factor X F10 0.0107
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0105
1729 Solute carrier family 22 member 6 SLC22A6 0.0104
2675 Pteridine reductase 1 PTR1 0.0104
1124 Sepiapterin reductase SPR 0.0104
891 Dihydropteroate synthase folP 0.0103
5359 Dihydropteroate synthase folP 0.0103
7175 Dihydropteroate synthase sulI 0.0103
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0101
862 Multidrug resistance-associated protein 1 ABCC1 0.0101
365 Dihydrofolate reductase DHFR 0.0099
2381 Dihydrofolate reductase DFR1 0.0099
2833 Dihydrofolate reductase Not Available 0.0099
2931 Dihydrofolate reductase folA 0.0099
3544 Dihydrofolate reductase folA 0.0099
3682 Dihydrofolate reductase folA 0.0099
6642 Dihydrofolate reductase folA 0.0099
6756 Dihydrofolate reductase dfrA 0.0099
6144 Solute carrier family 22 member 2 SLC22A2 0.0095
492 Histamine H1 receptor HRH1 0.0094
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0093
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0093
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0092
654 Flavin reductase BLVRB 0.0089
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0088
444 Alcohol dehydrogenase 1B ADH1B 0.0088
6137 Multidrug resistance-associated protein 6 ABCC6 0.0085
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0084
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0083
6145 Solute carrier family 22 member 1 SLC22A1 0.0082
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0077
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0076
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0075
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0075
122 P2Y purinoceptor 12 P2RY12 0.0075
776 Bile salt export pump ABCB11 0.0073
136 Estrogen receptor ESR1 0.0073
824 Sodium-dependent serotonin transporter SLC6A4 0.0071
2164 Multidrug resistance-associated protein 4 ABCC4 0.0071
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.007
822 Aldose reductase AKR1B1 0.007
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0068
70 Type-1 angiotensin II receptor AGTR1 0.0067
275 Arachidonate 5-lipoxygenase ALOX5 0.0064
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0064
468 Cytochrome P450 4A11 CYP4A11 0.0063
4076 Diacylglycerol kinase alpha DGKA 0.0063
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0063
375 SEC14-like protein 3 SEC14L3 0.0063
86 SEC14-like protein 4 SEC14L4 0.0063
708 Alpha-tocopherol transfer protein TTPA 0.0063
133 Dihydropterate synthase sulI 0.0063
283 SEC14-like protein 2 SEC14L2 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.006
997 Protein kinase C beta type PRKCB 0.006
6142 Solute carrier family 22 member 8 SLC22A8 0.006
6147 Solute carrier family 22 member 3 SLC22A3 0.006
6136 Multidrug resistance-associated protein 5 ABCC5 0.0059
341 5-hydroxytryptamine 3 receptor HTR3A 0.0058
3811 Cytochrome P450 19A1 CYP19A1 0.0057
502 5-hydroxytryptamine 2A receptor HTR2A 0.0056
1970 Protein kinase C alpha type PRKCA 0.0054
731 HIV-1 protease HIV-1 protease 0.0053
905 Glutathione transferase omega-1 GSTO1 0.0053
899 Glutathione S-transferase Mu 3 GSTM3 0.0053
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0051
3941 Amine oxidase [flavin-containing] A MAOA 0.0051
810 Heme oxygenase 1 HMOX1 0.005
3391 Heme oxygenase 1 pbsA1 0.005
540 Sodium-dependent noradrenaline transporter SLC6A2 0.005
6143 Solute carrier family 22 member 7 SLC22A7 0.005
817 DNA topoisomerase 2-alpha TOP2A 0.005
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.005
3939 Amine oxidase [flavin-containing] B MAOB 0.0049
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0048
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0047
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0046
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0046
3810 Catechol O-methyltransferase COMT 0.0046
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0045
1024 Solute carrier family 22 member 11 SLC22A11 0.0044
713 Sodium-dependent dopamine transporter SLC6A3 0.0044
49 Endothelin B receptor EDNRB 0.0044
6148 Multidrug resistance-associated protein 7 ABCC10 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
3932 Glutathione S-transferase A2 GSTA2 0.0041
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0041
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0041
590 5-hydroxytryptamine 2C receptor HTR2C 0.004
831 D(2) dopamine receptor DRD2 0.004
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0039
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0039
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0039
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0038
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0038
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0038
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0038
6168 Solute carrier family 22 member 16 SLC22A16 0.0037
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0037
260 Cytochrome P450 51 ERG11 0.0037
761 Cytochrome P450 51 ERG11 0.0037
3163 Cytochrome P450 51 cyp51 0.0037
130 Prostacyclin synthase PTGIS 0.0037
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0036
295 Carbonic anhydrase 1 CA1 0.0036
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0036
1275 Estrogen sulfotransferase SULT1E1 0.0036
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0035
118 Organic cation/carnitine transporter 2 SLC22A5 0.0035
592 Carbonic anhydrase 4 CA4 0.0035
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0034
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0033
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0033
847 Mu-type opioid receptor OPRM1 0.0033
696 Kappa-type opioid receptor OPRK1 0.0033
6031 Cytochrome P450 3A43 CYP3A43 0.0033
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0033
7 Nitric oxide synthase, inducible NOS2 0.0032
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0032
146 Androgen receptor AR 0.0032
556 Alpha-1A adrenergic receptor ADRA1A 0.0032
811 Translocator protein TSPO 0.0032
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
632 Alpha-1B adrenergic receptor ADRA1B 0.0031
3923 Cholinesterase BCHE 0.0031
467 Delta-type opioid receptor OPRD1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
766 Beta-2 adrenergic receptor ADRB2 0.0031
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0031
465 Calmodulin CALM1 0.003
318 Alpha-2A adrenergic receptor ADRA2A 0.003
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.003
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6102 Arylamine N-acetyltransferase 2 NAT2 0.0027
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0027
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0027
24 Thymidylate synthase TMP1 0.0027
359 Thymidylate synthase TYMS 0.0027
2626 Thymidylate synthase thyA 0.0027
2729 Thymidylate synthase thyA 0.0027
5352 Thymidylate synthase THYA 0.0027
23 D(1A) dopamine receptor DRD1 0.0027
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
6085 Fatty acid-binding protein, intestinal FABP2 0.0026
357 Carbonic anhydrase 2 CA2 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0026
427 Substance-P receptor TACR1 0.0025
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0025
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0025
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0025
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0025
1541 Metalloproteinase mmp20 0.0025
482 Glycine receptor subunit alpha-1 GLRA1 0.0024
183 Vascular endothelial growth factor A VEGFA 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0024
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0024
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
94 5-hydroxytryptamine 4 receptor HTR4 0.0023
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0023
4604 Liver carboxylesterase 1 CES1 0.0023
6182 Cytochrome P450 2J2 CYP2J2 0.0023
320 5-hydroxytryptamine 1A receptor HTR1A 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
407 Vascular endothelial growth factor receptor 2 KDR 0.0021
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0021
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0021
780 Retinoic acid receptor RXR-gamma RXRG 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
153 Dopamine beta-hydroxylase DBH 0.002
6220 Aryl hydrocarbon receptor AHR 0.002
1502 Peroxisome proliferator-activated receptor delta PPARD 0.002
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.002
6141 Sodium/bile acid cotransporter SLC10A1 0.0019
5122 Mersacidin decarboxylase mrsD 0.0019
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0019
5095 Putidaredoxin reductase camA 0.0019
3763 5,10-methylenetetrahydrofolate reductase metF 0.0019
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0019
5094 5,10-methylenetetrahydrofolate reductase metF 0.0019
526 Thioredoxin reductase trxB 0.0019
3767 Thioredoxin reductase trxB 0.0019
5078 Amine oxidase, flavin-containing PSPTO1126 0.0019
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0019
5109 Outer membrane protein p64k or PM-6 m-6 0.0019
5115 FkbI fkbI 0.0019
5083 Cryptochrome DASH cry 0.0019
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0019
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0019
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0019
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0019
5081 L-aspartate oxidase nadB 0.0019
1410 Oxidoreductase HSD17B6 0.0019
4725 Oxidoreductase Not Available 0.0019
5124 Oxidoreductase Not Available 0.0019
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0019
3133 UDP-galactopyranose mutase glf 0.0019
5099 UDP-galactopyranose mutase glf 0.0019
5111 Phenylacetone monooxygenase pamO 0.0019
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
777 Tumor necrosis factor TNF 0.0019
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0019
504 Mast/stem cell growth factor receptor KIT 0.0019
4486 Phenol 2-hydroxylase component B pheA2 0.0018
4477 Dihydrolipoyl dehydrogenase lpdV 0.0018
5077 Dihydrolipoyl dehydrogenase Not Available 0.0018
5117 Dihydrolipoyl dehydrogenase lpd 0.0018
4439 Ferredoxin reductase bphA4 0.0018
789 Alpha-1D adrenergic receptor ADRA1D 0.0018
869 Estrogen receptor beta ESR2 0.0018
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0018
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0018
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0018
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0018
738 Monocarboxylate transporter 1 SLC16A1 0.0018
3102 Flavohemoprotein hmp 0.0017
4969 Flavohemoprotein hmp 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0017
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0017
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
2268 Cholesterol oxidase choB 0.0017
2822 Cholesterol oxidase choA 0.0017
5072 N,N-dimethylglycine oxidase dmg 0.0017
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0017
3594 Deoxyribodipyrimidine photo-lyase phr 0.0017
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0017
5080 Deoxyribodipyrimidine photo-lyase phr 0.0017
2526 NADPH-ferredoxin reductase fprA fprA 0.0017
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0017
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0017
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0017
2470 Pyruvate oxidase pox5 0.0017
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0017
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0017
4440 NADH peroxidase npr 0.0016
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0016
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0016
6014 Cytochrome P450 2A13 CYP2A13 0.0016
1648 Elastin ELN 0.0015
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0015
2893 Glycine oxidase thiO 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0015
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0015
1656 CYP2B protein CYP2B 0.0015
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0015
327 Glutathione reductase gor 0.0015
5110 Glutathione reductase GR2 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
380 Cytochrome P450 17A1 CYP17A1 0.0015
208 DNA-directed RNA polymerase beta' chain rpoC 0.0015
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0015
833 Organic cation/carnitine transporter 1 SLC22A4 0.0015
126 D-lactate dehydrogenase dld 0.0015
3545 D-lactate dehydrogenase Not Available 0.0015
4510 D-lactate dehydrogenase ldhA 0.0015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
2567 Thymidylate synthase thyX thyX 0.0015
2823 Trypanothione reductase TPR 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
756 Sex hormone-binding globulin SHBG 0.0014
436 5-hydroxytryptamine 2B receptor HTR2B 0.0014
614 Progesterone receptor PGR 0.0014
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0014
629 Alpha-2B adrenergic receptor ADRA2B 0.0014
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0014
2769 P-hydroxybenzoate hydroxylase pobA 0.0014
2809 P-hydroxybenzoate hydroxylase pobA 0.0014
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0014
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0014
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0014
921 Glutamate receptor 2 GRIA2 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0014
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0014
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0014
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0014
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0014
2232 Interleukin-5 IL5 0.0014
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0014
1593 Mucin-2 MUC2 0.0014
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0013
885 5-hydroxytryptamine 1B receptor HTR1B 0.0013
2380 Monomeric sarcosine oxidase soxA 0.0013
844 Epidermal growth factor receptor EGFR 0.0013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0013
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0013
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0013
6645 D-amino-acid oxidase DAO 0.0013
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0013
823 Fibroblast growth factor receptor 2 FGFR2 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0012
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0012
124 Histamine H2 receptor HRH2 0.0012
193 Beta-1 adrenergic receptor ADRB1 0.0012
29 Tubulin beta-1 chain TUBB1 0.0012
518 Peroxidase/catalase T katG 0.0012
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0012
6149 Solute carrier family 22 member 10 SLC22A10 0.0011
474 Acetylcholinesterase ACHE 0.0011
164 Histamine H4 receptor HRH4 0.0011
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0011
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0011
1618 High affinity nerve growth factor receptor NTRK1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
228 Beta platelet-derived growth factor receptor PDGFRB 0.0011
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0011
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
638 D(3) dopamine receptor DRD3 0.0011
528 5-hydroxytryptamine 1E receptor HTR1E 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
106 Cannabinoid receptor 2 CNR2 0.0011
432 D(4) dopamine receptor DRD4 0.0011
714 Glutathione reductase, mitochondrial GSR 0.0011
1629 Transcription factor AP-1 JUN 0.0011
6174 50S ribosomal protein L32 rpmF 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
1196 Complement decay-accelerating factor CD55 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
3809 Estrogen-related receptor gamma ESRRG 0.001
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.001
68 Cannabinoid receptor 1 CNR1 0.001
563 Thyroid peroxidase TPO 0.001
6138 Multidrug resistance protein 3 ABCB4 0.001
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.001
4122 Histone deacetylase 2 HDAC2 0.001
16 Adenosine A1 receptor ADORA1 0.001
1178 Adenosine A2a receptor ADORA2A 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.001
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
716 5-hydroxytryptamine 7 receptor HTR7 0.0009
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0009
1341 Histamine H3 receptor HRH3 0.0009
2808 Chloramphenicol acetyltransferase 3 cat3 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
1192 Sulfotransferase 1A1 SULT1A1 0.0009
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0009
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0009
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
3808 Dihydropteroate synthase 2 folP2 0.0008
3601 Dihydropteroate synthase 1 folP1 0.0008
3807 Dihydropteroate synthase 1 folP1 0.0008
2417 Chloramphenicol acetyltransferase cat 0.0008
3278 Chloramphenicol acetyltransferase cat 0.0008
725 5-hydroxytryptamine 1D receptor HTR1D 0.0008
2810 Dr hemagglutinin structural subunit draA 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0008
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0008
26 Vascular endothelial growth factor receptor 3 FLT4 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0008
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0008
581 Cytochrome P450 2R1 CYP2R1 0.0008
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0008
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0008
32 Vascular endothelial growth factor receptor 1 FLT1 0.0008
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0008
3830 Calreticulin CALR 0.0008
4773 Deoxycytidine kinase DCK 0.0008
161 Tubulin beta chain TUBB 0.0008
312 Tubulin beta chain TUB2 0.0008
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
4948 Cytochrome c-553 Not Available 0.0007
4923 Cytochrome c3 DvMF_2499 0.0007
4945 Cytochrome c3 Not Available 0.0007
4949 Cytochrome c3 DVU_3171 0.0007
4968 Cytochrome c3 cytc3 0.0007
4997 Cytochrome c3 SO_2727 0.0007
5219 Cytochrome c3 cyd 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
4902 Nine-heme cytochrome c Ddes_2038 0.0007
3189 High-molecular-weight cytochrome c hmcA 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
737 Mineralocorticoid receptor NR3C2 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1630 Integrin beta-2 ITGB2 0.0007
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
373 Transthyretin TTR 0.0007
1374 Natriuretic peptides B NPPB 0.0007
1827 Gap junction alpha-1 protein GJA1 0.0007
1908 Vascular cell adhesion protein 1 VCAM1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0007
4217 Telomerase reverse transcriptase TERT 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0006
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0006
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0006
4386 Hemoglobin-like protein HbN glbN 0.0006
251 Alcohol dehydrogenase 1A ADH1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
719 Retinoic acid receptor responder protein 1 RARRES1 0.0006
378 Alpha-2C adrenergic receptor ADRA2C 0.0006
770 Retinoic acid-induced protein 3 GPRC5A 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
828 Phenylalanine-4-hydroxylase PAH 0.0006
3109 Phenylalanine-4-hydroxylase phhA 0.0006
163 D(1B) dopamine receptor DRD5 0.0006
6044 Serum paraoxonase/lactonase 3 PON3 0.0006
3221 Cytochrome c4 cc4 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
33 Cystine/glutamate transporter SLC7A11 0.0005
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0005
856 Vitamin D3 receptor VDR 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
267 Plasminogen activator inhibitor 1 SERPINE1 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0005
1507 Cytochrome c CYCS 0.0005
1268 Neuropeptide S receptor NPSR1 0.0005
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0005
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
6218 Pannexin-1 PANX1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0005
6221 Steroid hormone receptor ERR1 ESRRA 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0004
1039 Histone deacetylase 9 HDAC9 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0004
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
936 Ephrin type-A receptor 2 EPHA2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
165 FL cytokine receptor FLT3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
3957 Adenosine deaminase ADA 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
162 Retinoic acid receptor gamma-1 RARG 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0004
469 Annexin A1 ANXA1 0.0004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0004
284 DNA-directed RNA polymerase beta chain rpoB 0.0004
5773 DNA-directed RNA polymerase beta chain rpoB 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0003
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0003
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0003
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0003
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0003
2207 Rhodopsin RHO 0.0003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0003
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0003
489 Monocarboxylate transporter 2 SLC16A7 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0002
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0002
871 Glucocorticoid receptor NR3C1 0.0002
4954 Soluble cytochrome b558 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
5000 HemO hemO 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4984 Neuroglobin NGB 0.0002
4943 Cytochrome c6 petJ 0.0002
4910 Cytoglobin CYGB 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
4935 Cytochrome c-554 cycA1 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
3116 Bacterioferritin bfr 0.0002
4906 Bacterioferritin bfr 0.0002
4965 Bacterioferritin bfr 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4961 Hemophore HasA hasA 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
4920 Peroxidase/catalase katG 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
4990 PpcA ppcA 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
2298 Cytochrome P450-cam camC 0.0001
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