DT-Web

DB00451 - Levothyroxine


Identification
Name Levothyroxine
Accession Number DB00451 (APRD00235, EXPT02993)
Type small molecule
Description The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 776.87
Groups approved
Monoisotopic Weight 776.686681525
Pharmacology
Indication For use alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor.
Mechanism of action Levothyroxine acts like the endogenous thyroid hormone thyroxine (T4, a tetra-iodinated tyrosine derivative). In the liver and kidney, T4 is converted to T3, the active metabolite. In order to increase solubility, the thyroid hormones attach to thyroid hormone binding proteins, thyroxin-binding globulin, and thyroxin-binding prealbumin (transthyretin). Transport and binding to thyroid hormone receptors in the cytoplasm and nucleus then takes place. Thus by acting as a replacement for natural thyroxine, symptoms of thyroxine deficiency are relieved.
Absorption Bioavailability varies from 48% to 80%. Human studies have confirmed the importance of an intact jejunum and ileum for levothyroxine absorption and have shown some absorption from the duodenum.
Protein binding > 99% to serum proteins, including thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (TBA)
Biotransformation Approximately 70% of secreted T4 is deiodinated to equal amounts of T3 and reverse triiodothyronine (rT3), which is calorigenically inactive. Elimination of T4 and T3 involves hepatic conjugation to glucuronic and sulfuric acids. The hormones undergo enterohepatic circulation as conjugates are hydrolyzed in the intestine and reabsorbed. Conjugated compounds that reach the colon are hydrolyzed and eliminated as free compounds in the feces. Other minor T4 metabolites have been identified.
Route of elimination Thyroid hormones are primarily eliminated by the kidneys.
Toxicity LD50=20 mg/kg (orally in rat). Hypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The thyroid hormone, levothyroxine, increase the anticoagulant effect of acenocoumarol.
Anisindione The thyroid hormone, levothyroxine, increase the anticoagulant effect of anisindione.
Calcium Calcium decreases absorption of levothyroxine
Calcium Acetate Calcium salts such as calcium acetate may diminish the therapeutic effect of thyroid products such as levothyroxine. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
Calcium Chloride Calcium salts such as calcium chloride may diminish the therapeutic effect of thyroid products such as levothyroxine. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
Cholestyramine The resin, cholestyramine, decreases the absorption of the thyroid hormone, levothyroxine.
Colestipol The resin, colestipol, decreases the absorption of the thyroid hormone, levothyroxine.
Dicumarol The thyroid hormone, levothyroxine, increase the anticoagulant effect of dicumarol.
Digoxin The thyroid hormone, levothyroxine, decreases the effect of digoxin.
Iron Iron decreases absorption of levothyroxine
Iron Dextran Iron decreases the absorption of levothyroxine
Raloxifene Raloxifene decreases absorption of levothyroxine
Sucralfate Sucralfate decreases the effect of levothyroxine
Warfarin Levothyroxine may contribute to the anticoagulant effect of warfarin by increasing the metabolism of vitamin K-dependent clotting factors. Monitor for changes in prothrombin time and anticoagulant effects if levothyroxine is initiated, discontinued or dose changed.
Food Interactions
  • Absorption increased in fasting state and decreased in malabsorption states.
  • Consistent administration in relation to meals is recommended.
  • No iron or calium carbonate within 4 hours of taking this medication.
  • Oral administration with infant soybean formula, soybean flour, cotton seed meal, walnuts, foods containing large amounts of fiber, ferrous sulfate, and antacids may decrease drug absorption.
  • Take 30-60 minutes before breakfast.

Targets


Thyroid hormone receptor alpha
Name Thyroid hormone receptor alpha
Gene Name THRA
Pharmacological action yes
Actions agonist
References
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59. - Pubmed
  • Nakajima Y, Yamada M, Horiguchi K, Satoh T, Hashimoto K, Tokuhiro E, Onigata K, Mori M: Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor. Thyroid. 2010 Aug;20(8):917-26. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.744
Thyroid hormone receptor beta-1
Name Thyroid hormone receptor beta-1
Gene Name THRB
Pharmacological action yes
Actions agonist
References
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Marazuela M, Nattero L, Moure D, Garcia-Polo I, Figueroa-Vega N, Guijarro C: Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment. Thyroid. 2008 Oct;18(10):1119-23. - Pubmed
  • Sivakumar T, Chaidarun S: Resistance to thyroid hormone in a patient with coexisting Graves' disease. Thyroid. 2010 Feb;20(2):213-6. - Pubmed
  • Grasberger H, Ringkananont U, Croxson M, Refetoff S: Resistance to thyroid hormone in a patient with thyroid dysgenesis. Thyroid. 2005 Jul;15(7):730-3. - Pubmed
DTHybrid score 1.4905

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
DTHybrid score 0.3884
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5819

Transporters


Solute carrier organic anion transporter family member 1C1
Name Solute carrier organic anion transporter family member 1C1
Gene Name SLCO1C1
Actions substrate
References
  • Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. Epub 2008 Oct 9. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score 0.4801
Monocarboxylate transporter 8
Name Monocarboxylate transporter 8
Gene Name SLC16A2
Actions inhibitor
References
  • Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ: Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem. 2003 Oct 10;278(41):40128-35. Epub 2003 Jul 18. - Pubmed
DTHybrid score 0.3158
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inducer
References
  • Siegmund W, Altmannsberger S, Paneitz A, Hecker U, Zschiesche M, Franke G, Meng W, Warzok R, Schroeder E, Sperker B, Terhaag B, Cascorbi I, Kroemer HK: Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition. Clin Pharmacol Ther. 2002 Sep;72(3):256-64. - Pubmed
DTHybrid score 0.5775
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions Not Available
References
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score 0.4895
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions Not Available
References
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score 0.6247
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions Not Available
References
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score 0.4819
Solute carrier organic anion transporter family member 4A1
Name Solute carrier organic anion transporter family member 4A1
Gene Name SLCO4A1
Actions Not Available
References
  • Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. - Pubmed
DTHybrid score 0.4647
Solute carrier organic anion transporter family member 4C1
Name Solute carrier organic anion transporter family member 4C1
Gene Name SLCO4C1
Actions Not Available
References
  • Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. - Pubmed
DTHybrid score 0.5223
Large neutral amino acids transporter small subunit 1
Name Large neutral amino acids transporter small subunit 1
Gene Name SLC7A5
Actions Not Available
References
  • Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr;61(4):729-37. - Pubmed
DTHybrid score 0.6737

Carriers


Solute carrier organic anion transporter family member 1C1
Name Solute carrier organic anion transporter family member 1C1
Gene Name SLCO1C1
Actions
References Not Available
DTHybrid score 0.4801
Monocarboxylate transporter 8
Name Monocarboxylate transporter 8
Gene Name SLC16A2
Actions
References Not Available
DTHybrid score 0.3158
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.5775
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions
References Not Available
DTHybrid score 0.4895
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions
References Not Available
DTHybrid score 0.6247
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions
References Not Available
DTHybrid score 0.4819
Solute carrier organic anion transporter family member 4A1
Name Solute carrier organic anion transporter family member 4A1
Gene Name SLCO4A1
Actions
References Not Available
DTHybrid score 0.4647
Solute carrier organic anion transporter family member 4C1
Name Solute carrier organic anion transporter family member 4C1
Gene Name SLCO4C1
Actions
References Not Available
DTHybrid score 0.5223
Large neutral amino acids transporter small subunit 1
Name Large neutral amino acids transporter small subunit 1
Gene Name SLC7A5
Actions
References Not Available
DTHybrid score 0.6737

Predictions


Id Partner name Gene Name Score
6151 Monocarboxylate transporter 10 SLC16A10 0.2865
6142 Solute carrier family 22 member 8 SLC22A8 0.2546
4757 Cytochrome P450 2C9 CYP2C9 0.2533
6016 Cytochrome P450 2C19 CYP2C19 0.205
6141 Sodium/bile acid cotransporter SLC10A1 0.2014
4118 Cytochrome P450 3A5 CYP3A5 0.1994
4119 Cytochrome P450 2D6 CYP2D6 0.199
4200 Cytochrome P450 1A2 CYP1A2 0.1704
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1574
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1465
1729 Solute carrier family 22 member 6 SLC22A6 0.1374
6107 Cytochrome P450 3A7 CYP3A7 0.1284
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1266
6030 Cytochrome P450 2B6 CYP2B6 0.1218
6369 Thyroid hormone receptor, alpha isoform 1 variant Not Available 0.1207
862 Multidrug resistance-associated protein 1 ABCC1 0.1186
563 Thyroid peroxidase TPO 0.1166
6024 Cytochrome P450 1A1 CYP1A1 0.1
20 Prostaglandin G/H synthase 1 PTGS1 0.0924
2164 Multidrug resistance-associated protein 4 ABCC4 0.0895
776 Bile salt export pump ABCB11 0.0885
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0878
6013 Cytochrome P450 2E1 CYP2E1 0.0822
1024 Solute carrier family 22 member 11 SLC22A11 0.0807
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0771
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0769
6145 Solute carrier family 22 member 1 SLC22A1 0.0767
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0759
6167 Organic solute transporter subunit beta OSTB 0.0759
6166 Organic solute transporter subunit alpha OSTA 0.0759
6147 Solute carrier family 22 member 3 SLC22A3 0.0742
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0701
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0697
290 Prostaglandin G/H synthase 2 PTGS2 0.0668
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.0665
6143 Solute carrier family 22 member 7 SLC22A7 0.0648
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0622
1566 Corticoliberin CRH 0.058
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0561
136 Estrogen receptor ESR1 0.0555
3587 Gastrotropin FABP6 0.0553
5718 Cytochrome P450 2A6 CYP2A6 0.0538
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0527
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0498
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0475
738 Monocarboxylate transporter 1 SLC16A1 0.0465
6148 Multidrug resistance-associated protein 7 ABCC10 0.0456
70 Type-1 angiotensin II receptor AGTR1 0.0448
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0446
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0442
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0442
3811 Cytochrome P450 19A1 CYP19A1 0.0435
1898 Cytochrome P450 1B1 CYP1B1 0.0432
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.043
871 Glucocorticoid receptor NR3C1 0.0414
6106 Cytochrome P450 2C18 CYP2C18 0.0411
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0409
6144 Solute carrier family 22 member 2 SLC22A2 0.0401
118 Organic cation/carnitine transporter 2 SLC22A5 0.038
501 Leucine carboxyl methyltransferase 1 LCMT1 0.037
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0369
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0369
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0369
763 Tyrosine aminotransferase TAT 0.0369
5493 Tyrosine aminotransferase Not Available 0.0369
492 Histamine H1 receptor HRH1 0.0362
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0355
33 Cystine/glutamate transporter SLC7A11 0.0348
676 Tyrosine 3-monooxygenase TH 0.0339
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0338
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0336
831 D(2) dopamine receptor DRD2 0.0332
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0316
869 Estrogen receptor beta ESR2 0.0309
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0309
90 Tryptophan 5-hydroxylase 2 TPH2 0.0309
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0304
731 HIV-1 protease HIV-1 protease 0.0303
756 Sex hormone-binding globulin SHBG 0.0295
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0295
6136 Multidrug resistance-associated protein 5 ABCC5 0.0287
952 Dipeptidyl peptidase 4 DPP4 0.0287
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0286
833 Organic cation/carnitine transporter 1 SLC22A4 0.0277
23 D(1A) dopamine receptor DRD1 0.0269
1275 Estrogen sulfotransferase SULT1E1 0.0258
824 Sodium-dependent serotonin transporter SLC6A4 0.0255
556 Alpha-1A adrenergic receptor ADRA1A 0.0255
502 5-hydroxytryptamine 2A receptor HTR2A 0.0255
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0254
765 Indoleamine 2,3-dioxygenase IDO1 0.0254
891 Dihydropteroate synthase folP 0.025
5359 Dihydropteroate synthase folP 0.025
7175 Dihydropteroate synthase sulI 0.025
29 Tubulin beta-1 chain TUBB1 0.0246
6149 Solute carrier family 22 member 10 SLC22A10 0.0245
275 Arachidonate 5-lipoxygenase ALOX5 0.0242
146 Androgen receptor AR 0.0241
4604 Liver carboxylesterase 1 CES1 0.0239
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0238
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0233
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0231
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0231
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0231
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.023
320 5-hydroxytryptamine 1A receptor HTR1A 0.0227
2183 Fatty acid-binding protein, adipocyte FABP4 0.0227
6085 Fatty acid-binding protein, intestinal FABP2 0.0223
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0223
6012 Tryptophan 2,3-dioxygenase TDO2 0.0222
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0221
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0221
847 Mu-type opioid receptor OPRM1 0.0218
134 Tryptophan 5-hydroxylase 1 TPH1 0.0216
2452 Tryptophanyl-tRNA synthetase trpS 0.0213
578 Endothelin-1 receptor EDNRA 0.0206
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0205
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0202
3923 Cholinesterase BCHE 0.0196
467 Delta-type opioid receptor OPRD1 0.0194
244 Angiotensin-converting enzyme ACE 0.0192
6258 Protein S100-A7 S100A7 0.0191
617 Muscarinic acetylcholine receptor M2 CHRM2 0.019
696 Kappa-type opioid receptor OPRK1 0.0187
638 D(3) dopamine receptor DRD3 0.0186
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0184
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0184
468 Cytochrome P450 4A11 CYP4A11 0.0178
195 Monocarboxylate transporter 7 SLC16A6 0.0176
397 Monocarboxylate transporter 3 SLC16A8 0.0176
218 Monocarboxylate transporter 5 SLC16A4 0.0176
429 Monocarboxylate transporter 6 SLC16A5 0.0176
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0171
1389 Transforming growth factor beta-1 TGFB1 0.0169
5818 Folate receptor alpha FOLR1 0.0169
632 Alpha-1B adrenergic receptor ADRA1B 0.0168
489 Monocarboxylate transporter 2 SLC16A7 0.0168
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0167
6031 Cytochrome P450 3A43 CYP3A43 0.0161
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.016
904 Glutathione S-transferase P GSTP1 0.0156
3810 Catechol O-methyltransferase COMT 0.0155
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0154
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0152
432 D(4) dopamine receptor DRD4 0.0152
2539 Tubulin alpha-1 chain TUBA4A 0.0151
737 Mineralocorticoid receptor NR3C2 0.015
380 Cytochrome P450 17A1 CYP17A1 0.0149
24 Thymidylate synthase TMP1 0.0148
359 Thymidylate synthase TYMS 0.0148
2626 Thymidylate synthase thyA 0.0148
2729 Thymidylate synthase thyA 0.0148
5352 Thymidylate synthase THYA 0.0148
318 Alpha-2A adrenergic receptor ADRA2A 0.0147
260 Cytochrome P450 51 ERG11 0.0147
761 Cytochrome P450 51 ERG11 0.0147
3163 Cytochrome P450 51 cyp51 0.0147
293 Gamma-glutamyl hydrolase GGH 0.0147
844 Epidermal growth factor receptor EGFR 0.0146
6020 Aldehyde oxidase AOX1 0.0146
365 Dihydrofolate reductase DHFR 0.0145
2381 Dihydrofolate reductase DFR1 0.0145
2833 Dihydrofolate reductase Not Available 0.0145
2931 Dihydrofolate reductase folA 0.0145
3544 Dihydrofolate reductase folA 0.0145
3682 Dihydrofolate reductase folA 0.0145
6642 Dihydrofolate reductase folA 0.0145
6756 Dihydrofolate reductase dfrA 0.0145
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0145
885 5-hydroxytryptamine 1B receptor HTR1B 0.0143
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
6137 Multidrug resistance-associated protein 6 ABCC6 0.0142
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0141
3941 Amine oxidase [flavin-containing] A MAOA 0.0141
725 5-hydroxytryptamine 1D receptor HTR1D 0.0141
163 D(1B) dopamine receptor DRD5 0.014
614 Progesterone receptor PGR 0.0138
193 Beta-1 adrenergic receptor ADRB1 0.0138
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0137
6182 Cytochrome P450 2J2 CYP2J2 0.0136
766 Beta-2 adrenergic receptor ADRB2 0.0135
817 DNA topoisomerase 2-alpha TOP2A 0.0133
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0131
52 Pyruvate kinase isozymes R/L PKLR 0.0131
771 Pyruvate carboxylase, mitochondrial PC 0.0131
232 Corticosteroid-binding globulin SERPINA6 0.0131
1650 Heme carrier protein 1 SLC46A1 0.013
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0128
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0128
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0127
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0127
341 5-hydroxytryptamine 3 receptor HTR3A 0.0126
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0124
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0124
26 Vascular endothelial growth factor receptor 3 FLT4 0.0122
122 P2Y purinoceptor 12 P2RY12 0.0121
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0121
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.012
3917 Methylenetetrahydrofolate reductase MTHFR 0.012
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0119
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0119
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0118
4148 Serine/threonine-protein kinase mTOR MTOR 0.0118
789 Alpha-1D adrenergic receptor ADRA1D 0.0118
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0117
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0117
32 Vascular endothelial growth factor receptor 1 FLT1 0.0117
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0117
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0117
1852 Microtubule-associated protein 2 MAP2 0.0116
504 Mast/stem cell growth factor receptor KIT 0.0116
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0115
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0115
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0115
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0115
407 Vascular endothelial growth factor receptor 2 KDR 0.0115
2211 Fatty acid-binding protein, heart FABP3 0.0114
273 Apoptosis regulator Bcl-2 BCL2 0.0114
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0114
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0114
5880 Thrombopoietin receptor MPL 0.0114
3809 Estrogen-related receptor gamma ESRRG 0.0113
590 5-hydroxytryptamine 2C receptor HTR2C 0.0113
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0112
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.011
465 Calmodulin CALM1 0.011
500 Monocarboxylate transporter 4 SLC16A3 0.0106
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0106
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0103
811 Translocator protein TSPO 0.0103
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0101
5923 Microtubule-associated protein tau MAPT 0.0099
5924 Microtubule-associated protein 4 MAP4 0.0099
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
566 Serotransferrin TF 0.0094
4237 50S ribosomal protein L22 rplV 0.0094
768 FK506-binding protein 1A FKBP1A 0.0091
1353 DNA topoisomerase 1 TOP1 0.009
3552 DNA topoisomerase 1 topA 0.009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.009
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0087
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0087
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0087
436 5-hydroxytryptamine 2B receptor HTR2B 0.0087
511 5-hydroxytryptamine 1F receptor HTR1F 0.0086
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0085
705 Glutamate receptor 1 GRIA1 0.0085
228 Beta platelet-derived growth factor receptor PDGFRB 0.0085
629 Alpha-2B adrenergic receptor ADRA2B 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0085
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0084
6218 Pannexin-1 PANX1 0.0084
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0084
6102 Arylamine N-acetyltransferase 2 NAT2 0.0083
161 Tubulin beta chain TUBB 0.0083
312 Tubulin beta chain TUB2 0.0083
4120 NADPH--cytochrome P450 reductase POR 0.0083
6220 Aryl hydrocarbon receptor AHR 0.0083
713 Sodium-dependent dopamine transporter SLC6A3 0.0082
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0082
284 DNA-directed RNA polymerase beta chain rpoB 0.0082
5773 DNA-directed RNA polymerase beta chain rpoB 0.0082
4238 50S ribosomal protein L4 rplD 0.0082
5578 50S ribosomal protein L4 rplD 0.0082
6173 50S ribosomal protein L4 rplD 0.0082
6219 50S ribosomal protein L4 rplD 0.0082
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0082
558 Solute carrier family 12 member 1 SLC12A1 0.0082
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.008
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.008
4210 Toll-like receptor 4 TLR4 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0079
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0079
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
1291 cAMP response element-binding protein CREB1 0.0078
1517 Beta-3 adrenergic receptor ADRB3 0.0078
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0078
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0077
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0077
469 Annexin A1 ANXA1 0.0076
2981 Phospholipase A2, membrane associated PLA2G2A 0.0075
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0075
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0075
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0074
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0074
378 Alpha-2C adrenergic receptor ADRA2C 0.0074
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0073
1192 Sulfotransferase 1A1 SULT1A1 0.0073
474 Acetylcholinesterase ACHE 0.0073
537 ATP synthase delta chain, mitochondrial ATP5D 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
482 Glycine receptor subunit alpha-1 GLRA1 0.0072
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
6043 Putative G-protein coupled receptor 44 GPR44 0.0071
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.007
1525 Heparin-binding growth factor 2 FGF2 0.007
3932 Glutathione S-transferase A2 GSTA2 0.007
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.007
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0069
1630 Integrin beta-2 ITGB2 0.0069
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0069
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0069
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0068
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0067
6033 High affinity interleukin-8 receptor A CXCR1 0.0067
124 Histamine H2 receptor HRH2 0.0066
36 Insulin receptor INSR 0.0066
183 Vascular endothelial growth factor A VEGFA 0.0066
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0065
4122 Histone deacetylase 2 HDAC2 0.0065
777 Tumor necrosis factor TNF 0.0064
1050 Bile salt sulfotransferase SULT2A1 0.0064
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0064
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0064
3939 Amine oxidase [flavin-containing] B MAOB 0.0064
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0064
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0064
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0064
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0063
3856 Fibroblast growth factor receptor 3 FGFR3 0.0063
1010 Cytochrome P450 51A1 CYP51A1 0.0062
6501 Fatty acid-binding protein, liver FABP1 0.0062
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0061
88 Retinoic acid receptor RXR-beta RXRB 0.0061
3947 Xanthine dehydrogenase/oxidase XDH 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
3382 Glycolipid transfer protein GLTP 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0058
716 5-hydroxytryptamine 7 receptor HTR7 0.0058
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
6138 Multidrug resistance protein 3 ABCB4 0.0057
2449 Tubulin alpha-3 chain TUBA1A 0.0056
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0056
6044 Serum paraoxonase/lactonase 3 PON3 0.0056
2391 Ferrochelatase hemH 0.0056
6502 Ferrochelatase DKFZp686P18130 0.0056
1591 Ferrochelatase, mitochondrial FECH 0.0056
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0055
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0055
1656 CYP2B protein CYP2B 0.0054
477 DNA topoisomerase 4 subunit A parC 0.0054
886 DNA topoisomerase 4 subunit A parC 0.0054
6226 DNA topoisomerase 4 subunit A parC 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
404 DNA gyrase subunit A gyrA 0.0053
6224 DNA gyrase subunit A gyrA 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
6014 Cytochrome P450 2A13 CYP2A13 0.0053
572 Integrin alpha-L ITGAL 0.0052
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0052
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0051
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0051
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0051
162 Retinoic acid receptor gamma-1 RARG 0.0051
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0051
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
5787 Angiopoietin-1 receptor TEK 0.005
5300 Antigen peptide transporter 1 TAP1 0.005
606 Cytochrome P450 27, mitochondrial CYP27A1 0.005
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.005
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
2236 Casein kinase II subunit alpha CSNK2A1 0.0049
1541 Metalloproteinase mmp20 0.0049
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0049
229 Retinoic acid receptor beta RARB 0.0049
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0048
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0048
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0048
814 Ryanodine receptor 1 RYR1 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
6493 Cytochrome c oxidase subunit 6C COX6C 0.0048
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0048
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0048
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0048
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0048
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0048
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0048
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0048
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0048
6559 Cytochrome c oxidase subunit 2 ctaC 0.0048
6669 Cytochrome c oxidase subunit 2 ctaC 0.0048
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0048
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0048
6558 Cytochrome c oxidase subunit 1 ctaD 0.0048
730 Retinoic acid receptor alpha RARA 0.0048
6677 Myelin P2 protein PMP2 0.0047
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0047
6103 Arylamine N-acetyltransferase 1 NAT1 0.0047
5934 Cytochrome P450 26A1 CYP26A1 0.0047
459 Retinoic acid receptor RXR-alpha RXRA 0.0047
683 Potassium transporter GK0582 0.0047
6228 Nuclear receptor coactivator 1 NCOA1 0.0046
1760 Aminopeptidase N ANPEP 0.0046
6843 Aminopeptidase N pepN 0.0046
68 Cannabinoid receptor 1 CNR1 0.0045
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0045
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0044
2540 Choloylglycine hydrolase cbh 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0044
976 Platelet glycoprotein IX GP9 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
1629 Transcription factor AP-1 JUN 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
751 Potassium channel subfamily K member 6 KCNK6 0.0043
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0043
856 Vitamin D3 receptor VDR 0.0043
780 Retinoic acid receptor RXR-gamma RXRG 0.0043
633 Penicillin-binding proteins 1A/1B pbpA 0.0043
6241 Nuclear receptor coactivator 2 NCOA2 0.0043
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0041
1757 Myeloperoxidase MPO 0.0041
2021 Thrombomodulin THBD 0.0041
427 Substance-P receptor TACR1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1618 High affinity nerve growth factor receptor NTRK1 0.004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.004
4203 Histamine N-methyltransferase HNMT 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
172 Potassium channel subfamily K member 1 KCNK1 0.004
1178 Adenosine A2a receptor ADORA2A 0.0039
239 Coagulation factor X F10 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
319 Opioid receptor, sigma 1 OPRS1 0.0039
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0037
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0037
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0037
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0037
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0037
4102 Proteasome subunit beta type 5 PSMB5 0.0037
4101 Proteasome subunit beta type 1 PSMB1 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
165 FL cytokine receptor FLT3 0.0036
3616 Fatty acid-binding protein, epidermal FABP5 0.0036
5431 Lipid binding protein Not Available 0.0036
5433 UPF0230 protein TM_1468 TM_1468 0.0036
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
84 Nuclear receptor 0B1 NR0B1 0.0036
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0035
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
2112 Toll-like receptor 9 TLR9 0.0035
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
295 Carbonic anhydrase 1 CA1 0.0034
1992 Vitamin D-binding protein GC 0.0034
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
6500 Phospholipase A2 PLA2G1B 0.0034
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
357 Carbonic anhydrase 2 CA2 0.0034
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0033
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0033
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0033
6432 Transporter snf 0.0033
6824 Tyrosine-protein kinase Lyn LYN 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0033
6459 Glycodelin PAEP 0.0033
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0033
517 Alcohol dehydrogenase 1C ADH1C 0.0033
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0033
707 72 kDa type IV collagenase MMP2 0.0033
1867 Major prion protein PRNP 0.0032
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0032
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
528 5-hydroxytryptamine 1E receptor HTR1E 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
595 Fibrinogen alpha chain FGA 0.0032
6168 Solute carrier family 22 member 16 SLC22A16 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
4217 Telomerase reverse transcriptase TERT 0.0031
6174 50S ribosomal protein L32 rpmF 0.0031
760 Fibroblast growth factor 1 FGF1 0.0031
16 Adenosine A1 receptor ADORA1 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1256 5-hydroxytryptamine 6 receptor HTR6 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
1648 Elastin ELN 0.0031
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0031
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2207 Rhodopsin RHO 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
283 SEC14-like protein 2 SEC14L2 0.003
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.003
94 5-hydroxytryptamine 4 receptor HTR4 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
208 DNA-directed RNA polymerase beta' chain rpoC 0.003
5774 DNA-directed RNA polymerase beta' chain rpoC 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
1714 Mitogen-activated protein kinase 3 MAPK3 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0029
1792 Tissue-type plasminogen activator PLAT 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
65 Matrix metalloproteinase-9 Not Available 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
267 Plasminogen activator inhibitor 1 SERPINE1 0.0028
921 Glutamate receptor 2 GRIA2 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
605 Fumarate reductase flavoprotein subunit frdA 0.0027
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0027
3673 Fumarate reductase flavoprotein subunit fccA 0.0027
4912 Fumarate reductase flavoprotein subunit ifcA 0.0027
6549 Fumarate reductase flavoprotein subunit frdA 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
4311 tRNA TRDMT1 0.0026
4325 tRNA trmD 0.0026
4328 tRNA trmD 0.0026
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
581 Cytochrome P450 2R1 CYP2R1 0.0026
49 Endothelin B receptor EDNRB 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
551 Carnitine O-acetyltransferase CRAT 0.0025
6221 Steroid hormone receptor ERR1 ESRRA 0.0025
823 Fibroblast growth factor receptor 2 FGFR2 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
6042 Prostaglandin reductase 2 PTGR2 0.0025
518 Peroxidase/catalase T katG 0.0025
7 Nitric oxide synthase, inducible NOS2 0.0025
2320 Thymidine kinase, cytosolic TK1 0.0025
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0025
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0025
3426 Glutamine synthetase glnA 0.0025
3987 Glutamine synthetase GLUL 0.0025
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
4192 DNA topoisomerase 2-beta TOP2B 0.0022
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0022
4773 Deoxycytidine kinase DCK 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
4226 Uridine phosphorylase 2 UPP2 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6755 Poliovirus receptor PVR 0.002
4225 Uridine phosphorylase 1 UPP1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
1313 Lactoylglutathione lyase GLO1 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
54 Prothrombin F2 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
413 Amidophosphoribosyltransferase PPAT 0.0018
2515 Amidophosphoribosyltransferase purF 0.0018
3714 Amidophosphoribosyltransferase purF 0.0018
2808 Chloramphenicol acetyltransferase 3 cat3 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
174 Sigma 1-type opioid receptor SIGMAR1 0.0018
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0018
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0017
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
3957 Adenosine deaminase ADA 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
1864 RET proto-oncogene RET 0.0017
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0017
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0017
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0017
908 Glutathione S-transferase theta-1 GSTT1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
2810 Dr hemagglutinin structural subunit draA 0.0016
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0016
6146 High affinity copper uptake protein 1 SLC31A1 0.0016
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
173 Toll-like receptor 7 TLR7 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
3233 Bile acid receptor NR1H4 0.0015
702 UMP-CMP kinase CMPK1 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
3639 Thymidine phosphorylase deoA 0.0015
3936 Thymidine phosphorylase TYMP 0.0015
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0013
164 Histamine H4 receptor HRH4 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
822 Aldose reductase AKR1B1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0012
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0012
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0012
6859 Protein S100-A4 S100A4 0.0012
719 Retinoic acid receptor responder protein 1 RARRES1 0.0012
770 Retinoic acid-induced protein 3 GPRC5A 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0011
1268 Neuropeptide S receptor NPSR1 0.0011
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0011
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
6073 Potassium channel subfamily K member 9 KCNK9 0.001
6072 Potassium channel subfamily K member 3 KCNK3 0.001
569 Retinal dehydrogenase 2 ALDH1A2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
611 Retinal dehydrogenase 1 ALDH1A1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
291 Nitric-oxide synthase, endothelial NOS3 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2298 Cytochrome P450-cam camC 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3221 Cytochrome c4 cc4 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
4943 Cytochrome c6 petJ 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4916 Cyanoglobin glbN 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
5000 HemO hemO 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4984 Neuroglobin NGB 0.0006
4961 Hemophore HasA hasA 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4909 CooA protein cooA 0.0006
4910 Cytoglobin CYGB 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4972 P450cin cinA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4952 Catalase/peroxidase katA 0.0006
3093 Catalase HPII katE 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6749 Polyprotein Not Available 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
4920 Peroxidase/catalase katG 0.0005
5961 Insulin INS 0.0005
4948 Cytochrome c-553 Not Available 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4923 Cytochrome c3 DvMF_2499 0.0005
4945 Cytochrome c3 Not Available 0.0005
4949 Cytochrome c3 DVU_3171 0.0005
4968 Cytochrome c3 cytc3 0.0005
4997 Cytochrome c3 SO_2727 0.0005
5219 Cytochrome c3 cyd 0.0005
4902 Nine-heme cytochrome c Ddes_2038 0.0005
3189 High-molecular-weight cytochrome c hmcA 0.0005
4990 PpcA ppcA 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
4037 Hypothetical protein GPX1 0.0005
4297 Hypothetical protein SP_1951 0.0005
4521 Hypothetical protein BC_2969 0.0005
4540 Hypothetical protein TM_1070 0.0005
4555 Hypothetical protein MT1739 0.0005
4569 Hypothetical protein mshD 0.0005
4578 Hypothetical protein PA3270 0.0005
4747 Hypothetical protein PA3967 0.0005
5177 Hypothetical protein TM_0096 0.0005
5194 Hypothetical protein PA1204 0.0005
5240 Hypothetical protein Rv2991 0.0005
5370 Hypothetical protein TM_1158 0.0005
5710 Hypothetical protein Tb927.5.1360 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6524 Protein tonB tonB 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
4386 Hemoglobin-like protein HbN glbN 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
3127 Nitrite reductase nirS 0.0004
3284 Nitrite reductase nirS 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
358 Cystathionine beta-synthase CBS 0.0003
1507 Cytochrome c CYCS 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
693 Hemoglobin subunit beta HBB 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
↑