DT-Web: DB00390

Identification

Name

Digoxin

Accession Number

DB00390 (APRD00098)

Type

small molecule

Description

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone digoxigenin. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

780.9385

Groups

approved

Monoisotopic Weight

780.429606756

Pharmacology

Indication

For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.

Mechanism of action

Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium. The sodium calcium exchanger (NCX)in turn tries to extrude the sodium and in so doing, pumps in more calcium. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

Absorption

Absorption of digoxin from the elixir pediatric formulation has been demonstrated to be 70% to 85% complete (90% to 100% from the capsules, and 60% to 80% for tablets).

Protein binding

25%

Biotransformation

Hepatic (but not dependent upon the cytochrome P-450 system). The end metabolites, which include 3 b-digoxigenin, 3-keto-digoxigenin, and their glucuronide and sulfate conjugates, are polar in nature and are postulated to be formed via hydrolysis, oxidation, and conjugation.

Route of elimination

Following intravenous administration to healthy volunteers, 50% to 70% of a digoxin dose is excreted unchanged in the urine.

Toxicity

Toxicity includes ventricular tachycardia or ventricular fibrillation, or progressive bradyarrhythmias, or heart block. LD₅₀ = 7.8 mg/kg (orally in mice).

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acarbose	Acarbose may decrease the serum levels of digoin. It is thought that acarbose reduces digoin absorption. Monitor for changes in digoxin serum levels and therapeutic and adverse effects if acarbose is initiated, discontinued or dose changed.
Alprazolam	The benzodiazepine, alprazolam, may increase the effect of digoxin.
Amiodarone	Amiodarone may increase the effect of digoxin.
Bendroflumethiazide	Possible electrolyte variations and arrhythmias
Benzthiazide	Possible electrolyte variations and arrhythmias
Bleomycin	The antineoplasic agent decreases the effect of digoxin
Bosutinib	Bosutinib is a substrate and inhibitor of p-glycoprotein (p-gp) and may increase levels of other p-gp substrates.
Bumetanide	Possible electrolyte variations and arrhythmias
Canagliflozin	When coadministered with 300 mg canagliflozin, the AUC and mean peak drug concentration of digoxin increased. Monitor concomitant therapy closely.
Carmustine	The antineoplasic agent decreases the effect of digoxin
Carvedilol	Carvedilol may increase the serum levels and effect of digoxin.
Chlorothiazide	Possible electrolyte variations and arrhythmias
Chlorthalidone	Possible electrolyte variations and arrhythmias
Cholestyramine	The resin decreases the effect of digoxin
Cinitapride	Cinitapride can alter the absorption of digoxin as it simulates gastric emptying.
Clarithromycin	The macrolide, clarithromycin, may increase the effect of digoxin in 10% of patients.
Colestipol	The resin decreases the effect of digoxin
Cyclophosphamide	The antineoplasic agent decreases the effect of digoxin
Cyclosporine	Cyclosporine may increase the effect of digoxin.
Cyclothiazide	Possible electrolyte variations and arrhythmias
Cytarabine	The antineoplasic agent decreases the effect of digoxin
Dextrothyroxine	The thyroid hormone, dextrothyroxine, decreases the effect of digoxin.
Diazepam	The benzodiazepine, diazepam, may increase the effect of digoxin.
Dihydroquinidine barbiturate	Quinine/quinidine increases the effect of digoxin
Doxorubicin	The antineoplasic agent decreases the effect of digoxin
Dronedarone	Dronedarone inhibits P-glycoprotein transporter thus increasing serum concentrations of digoxin 2.5-fold.
Erythromycin	The macrolide, erythromycin, may increase the effect of digoxin in 10% of patients.
Ethacrynic acid	Possible electrolyte variations and arrhythmias
Etravirine	Digoxin, when administered concomitantly with etravirine, may experience an increase in serum concentration. It is recommended to monitor serum levels of digoxin and titrate dosage to achieve desired therapeutic range. Pre-emptive dose adjustments are not required.
Furosemide	Possible electrolyte variations and arrhythmias
Gatifloxacin	Gatifloxacin increases the effect of digoxin
Ginseng	Changes in digoxin serum levels
Hydrochlorothiazide	Possible electrolyte variations and arrhythmias
Hydroflumethiazide	Possible electrolyte variations and arrhythmias
Hydroxychloroquine	Hydroxychloroquine increases the effect of digoxin
Indapamide	Possible electrolyte variations and arrhythmias
Itraconazole	Itraconazole increases the effect of digoxin
Josamycin	The macrolide, josamycin, may increase the effect of digoxin in 10% of patients.
Levothyroxine	The thyroid hormone, levothyroxine, decreases the effect of digoxin.
Liothyronine	The thyroid hormone, liothyronine, decreases the effect of digoxin.
Liotrix	The thyroid hormone, liotrix, decreases the effect of digoxin.
Liraglutide	These agents may have decreased C max and a delayed T max during coadministration.
Methimazole	The antithyroid agent increases the effect of digoxin
Methotrexate	The antineoplasic agent decreases the effect of digoxin
Methyclothiazide	Possible electrolyte variations and arrhythmias
Metolazone	Possible electrolyte variations and arrhythmias
Milnacipran	Use of Savella concomitantly with digoxin may be associated with potentiation of adverse hemodynamic effects. Co-administration of Savella and intravenous digoxin should be avoided.
Mirabegron	Mirabegron increased Cmax and AUC of digoxin. Initiate therapy with digoxin at lowest possible dose. Monitor concomitant therapy closely.
Penbutolol	Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.
Penciclovir	The multivalent agent decreases the effect of penicillamine
Penicillamine	Penicillamine decreases the effect of digoxin
Polythiazide	Possible electrolyte variations and arrhythmias
Prazosin	Prazosin increases the effect of digoxin
Procarbazine	The antineoplasic agent decreases the effect of digoxin
Propafenone	Propafenone increases the effect of digoxin
Propylthiouracil	The antithyroid agent may increase the effect of digoxin.
Quinethazone	Possible electrolyte variations and arrhythmias
Quinidine	Quinine/quinidine increases the effect of digoxin
Quinidine barbiturate	Quinine/quinidine increases the effect of digoxin
Quinine	Quinine/quinidine increases the effect of digoxin
Rabeprazole	Rabeprazole increases the effect of digoxin
Ranolazine	Ranolazine may increase the serum level of digoxin. Monitor for changes in the serum level and therapeutic and adverse effects of digoxin if ranolazine is initiated, discontinued or dose changed.
Ritonavir	Ritonavir increases levels/effect of digoxin
Spironolactone	Increased digoxin levels and decreased effect in presence of spironolactone
St. John's Wort	St. John's Wort decreases the effect of digoxin
Sulfasalazine	Sulfasalazine may decrease the effect of digoxin.
Telaprevir	Telaprevir is a substrate of p-glycoprotein and thus increases the AUC and Cmax of digoxin. This indicates an increased absorption of digoxin. Lowest dose of digoxin should be used first and levels be closely monitored.
Telithromycin	Telithromycin may increase the plasma concentration of Digoxin. Monitor for changes in Digoxin efficacy/toxicity if Telithromycin is initiated, discontinued or dose changed.
Telmisartan	Telmisartan may increase plasma Digoxin concentrations. Monitor Digoxin levels and adjust dose as required if Telmisartan is initiated, discontinued or dose changed.
Thyroglobulin	The thyroid hormone, thyroglobulin, decreases the effect of digoxin.
Ticlopidine	Ticlopidine may decrease Digoxin levels. Monitor for Digoxin levels with Ticlopidine is initiated, discontinued or dose changed.
Tolbutamide	Tolbutamide increases the effect of digoxin
Tolvaptan	Tolvaptan increases serum digoxin concentrations due to competitive inhibition of P-glycoprotein in the liver, intestine, and kidney. P-glycoprotein facilitates digoxin efflux thus inhibition of this protein will increase incidence of adverse effects.
Trichlormethiazide	Possible electrolyte variations and arrhythmias
Trimetrexate	The absorption of Digoxin, a cardiac glycoside, may be decreased by antineoplastic agents such as Trimetrexate. Liquid forms of Digoxin do not appear to be significantly affected. Monitor Digoxin tablet efficacy if Trimetrexate therapy is initiated, discontinued or if the dose is altered.
Verapamil	Verapamil may increase the serum concentration of Digoxin by decreasing its metabolism and clearance. Monitor for changes in the therapeutic/adverse effects of Digoxin if Verpamail is initiated, discontinued or dose changed.
Vincristine	The antineoplasic agent decreases the effect of digoxin
Voriconazole	Voriconazole may increase the serum concentration of digoxin. Monitor for increased serum concentrations and toxic effects of digoxin if voriconazole is initiated or dose increased.

Food Interactions

Avoid avocado.
Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
Avoid salt substitutes containing potassium.
Avoid bran and high fiber foods within 2 hours of taking this medication.
Avoid excess salt/sodium unless otherwise instructed by your physician.
Limit garlic, ginger, gingko, and horse chestnut.

Sodium/potassium-transporting ATPase alpha-1 chain
Name	Sodium/potassium-transporting ATPase alpha-1 chain
Gene Name	ATP1A1
Pharmacological action	yes
Actions	Not Available
References	Ravikumar A, Arun P, Devi KV, Augustine J, Kurup PA: Isoprenoid pathway and free radical generation and damage in neuropsychiatric disorders. Indian J Exp Biol. 2000 May;38(5):438-46. - Pubmed Chen JJ, Wang PS, Chien EJ, Wang SW: Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells. Br J Pharmacol. 2001 Apr;132(8):1761-8. - Pubmed Ke YS, Liu ZF, Yang H, Yang T, Huang JS, Rui SB, Cheng GH, Wang YX: Effect of anti-digoxin antiserum on endoxin and membrane ATPase activity in hypoxia-reoxygenation induced myocardial injury. Acta Pharmacol Sin. 2000 Apr;21(4):345-7. - Pubmed Kumar AR, Kurup PA: A hypothalamic digoxin mediated model for conscious and subliminal perception. J Neural Transm. 2001;108(7):855-68. - Pubmed Aizman O, Uhlen P, Lal M, Brismar H, Aperia A: Ouabain, a steroid hormone that signals with slow calcium oscillations. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13420-4. Epub 2001 Oct 30. - Pubmed
DTHybrid score	0.8961

Cholesterol side-chain cleavage enzyme, mitochondrial
Name	Cholesterol side-chain cleavage enzyme, mitochondrial
Gene Name	CYP11A1
Actions	inhibitor
References	- Chen JJ, Wang PS, Chien EJ, Wang SW: Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells. Br J Pharmacol. 2001 Apr;132(8):1761-8. - Pubmed Wang SW, Pu HF, Kan SF, Tseng CI, Lo MJ, Wang PS: Inhibitory effects of digoxin and digitoxin on corticosterone production in rat zona fasciculata-reticularis cells. Br J Pharmacol. 2004 Aug;142(7):1123-30. Epub 2004 Jul 12. - Pubmed Lin H, Wang SW, Tsai SC, Chen JJ, Chiao YC, Lu CC, Huang WJ, Wang GJ, Chen CF, Wang PS: Inhibitory effect of digoxin on testosterone secretion through mechanisms involving decreases of cyclic AMP production and cytochrome P450scc activity in rat testicular interstitial cells. Br J Pharmacol. 1998 Dec;125(8):1635-40. - Pubmed
DTHybrid score	0.2877
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5714

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Takara K, Tsujimoto M, Ohnishi N, Yokoyama T: Digoxin up-regulates MDR1 in human colon carcinoma Caco-2 cells. Biochem Biophys Res Commun. 2002 Mar 22;292(1):190-4. - Pubmed Takara K, Takagi K, Tsujimoto M, Ohnishi N, Yokoyama T: Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor mRNA. Biochem Biophys Res Commun. 2003 Jun 20;306(1):116-20. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Takara K, Tanigawara Y, Komada F, Nishiguchi K, Sakaeda T, Okumura K: Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs. Biol Pharm Bull. 1999 Dec;22(12):1355-9. - Pubmed Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH: In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J Pharmacol Exp Ther. 2001 Mar;296(3):723-35. - Pubmed Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed Neuhoff S, Ungell AL, Zamora I, Artursson P: pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. Pharm Res. 2003 Aug;20(8):1141-8. - Pubmed Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed Dagenais C, Graff CL, Pollack GM: Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochem Pharmacol. 2004 Jan 15;67(2):269-76. - Pubmed Taipalensuu J, Tavelin S, Lazorova L, Svensson AC, Artursson P: Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity. Eur J Pharm Sci. 2004 Jan;21(1):69-75. - Pubmed Tanigawara Y, Okamura N, Hirai M, Yasuhara M, Ueda K, Kioka N, Komano T, Hori R: Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther. 1992 Nov;263(2):840-5. - Pubmed Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM: Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments] Circulation. 1999 Feb 2;99(4):552-7. - Pubmed Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ: Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr;16(4):478-85. - Pubmed Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. - Pubmed Yamaguchi H, Yano I, Saito H, Inui K: Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats. Pharm Res. 2004 Feb;21(2):330-8. - Pubmed Takara K, Sakaeda T, Kakumoto M, Tanigawara Y, Kobayashi H, Okumura K, Ohnishi N, Yokoyama T: Effects of alpha-adrenoceptor antagonist doxazosin on MDR1-mediated multidrug resistance and transcellular transport. Oncol Res. 2009;17(11-12):527-33. - Pubmed Jutabha P, Wempe MF, Anzai N, Otomo J, Kadota T, Endou H: Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan;61(1):76-84. Epub 2009 Jul 21. - Pubmed
DTHybrid score	0.5779
Solute carrier organic anion transporter family member 4C1
Name	Solute carrier organic anion transporter family member 4C1
Gene Name	SLCO4C1
Actions	inhibitor
References	Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. - Pubmed
DTHybrid score	0.3791
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score	0.4483
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	substrate
References	Nishio T, Adachi H, Nakagomi R, Tokui T, Sato E, Tanemoto M, Fujiwara K, Okabe M, Onogawa T, Suzuki T, Nakai D, Shiiba K, Suzuki M, Ohtani H, Kondo Y, Unno M, Ito S, Iinuma K, Nunoki K, Matsuno S, Abe T: Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. Biochem Biophys Res Commun. 2000 Sep 7;275(3):831-8. - Pubmed
DTHybrid score	0.4004
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	substrate
References	Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed
DTHybrid score	0.2709
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	substrate
References	Hagenbuch B, Adler ID, Schmid TE: Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20. - Pubmed Noe B, Hagenbuch B, Stieger B, Meier PJ: Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10346-50. - Pubmed
DTHybrid score	0.5385
Organic solute transporter subunit alpha
Name	Organic solute transporter subunit alpha
Gene Name	OSTA
Actions	substrate
References	Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. - Pubmed
DTHybrid score	0.2437
Organic solute transporter subunit beta
Name	Organic solute transporter subunit beta
Gene Name	OSTB
Actions	substrate
References	Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. - Pubmed
DTHybrid score	0.2438
Solute carrier organic anion transporter family member 4A1
Name	Solute carrier organic anion transporter family member 4A1
Gene Name	SLCO4A1
Actions	substrate
References	Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. - Pubmed
DTHybrid score	0.3633
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	substrate
References	Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score	0.4599
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions	substrate
References	Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score	0.3968
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	substrate,inhibitor
References	van Montfoort JE, Schmid TE, Adler ID, Meier PJ, Hagenbuch B: Functional characterization of the mouse organic-anion-transporting polypeptide 2. Biochim Biophys Acta. 2002 Aug 19;1564(1):183-8. - Pubmed Dagenais C, Ducharme J, Pollack GM: Uptake and efflux of the peptidic delta-opioid receptor agonist. Neurosci Lett. 2001 Apr 6;301(3):155-8. - Pubmed Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. - Pubmed Hagenbuch N, Reichel C, Stieger B, Cattori V, Fattinger KE, Landmann L, Meier PJ, Kullak-Ublick GA: Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver. J Hepatol. 2001 Jun;34(6):881-7. - Pubmed Gao B, Wenzel A, Grimm C, Vavricka SR, Benke D, Meier PJ, Reme CE: Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2002 Feb;43(2):510-4. - Pubmed Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed
DTHybrid score	0.5856

Id	Partner name	Gene Name	Score
1729	Solute carrier family 22 member 6	SLC22A6	0.2413
4924	Cytochrome P450 2C8	CYP2C8	0.2293
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.2151
587	Serum albumin	ALB	0.2119
4757	Cytochrome P450 2C9	CYP2C9	0.2095
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.209
4118	Cytochrome P450 3A5	CYP3A5	0.198
4119	Cytochrome P450 2D6	CYP2D6	0.1906
6141	Sodium/bile acid cotransporter	SLC10A1	0.1893
6016	Cytochrome P450 2C19	CYP2C19	0.1892
4200	Cytochrome P450 1A2	CYP1A2	0.1834
862	Multidrug resistance-associated protein 1	ABCC1	0.1787
1024	Solute carrier family 22 member 11	SLC22A11	0.1732
2164	Multidrug resistance-associated protein 4	ABCC4	0.158
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.155
758	Thyroid hormone receptor alpha	THRA	0.1549
6145	Solute carrier family 22 member 1	SLC22A1	0.135
346	Thyroid hormone receptor beta-1	THRB	0.1308
6107	Cytochrome P450 3A7	CYP3A7	0.1287
6143	Solute carrier family 22 member 7	SLC22A7	0.1258
6024	Cytochrome P450 1A1	CYP1A1	0.1242
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1206
6030	Cytochrome P450 2B6	CYP2B6	0.1104
594	Thyroxine-binding globulin	SERPINA7	0.1104
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.1077
3811	Cytochrome P450 19A1	CYP19A1	0.1036
738	Monocarboxylate transporter 1	SLC16A1	0.0973
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0946
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0939
3587	Gastrotropin	FABP6	0.0896
6148	Multidrug resistance-associated protein 7	ABCC10	0.0782
6144	Solute carrier family 22 member 2	SLC22A2	0.0778
136	Estrogen receptor	ESR1	0.0746
6013	Cytochrome P450 2E1	CYP2E1	0.0738
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0696
373	Transthyretin	TTR	0.0683
6136	Multidrug resistance-associated protein 5	ABCC5	0.0648
20	Prostaglandin G/H synthase 1	PTGS1	0.0634
33	Cystine/glutamate transporter	SLC7A11	0.0632
199	Monocarboxylate transporter 8	SLC16A2	0.0591
1898	Cytochrome P450 1B1	CYP1B1	0.0587
118	Organic cation/carnitine transporter 2	SLC22A5	0.0587
5718	Cytochrome P450 2A6	CYP2A6	0.0582
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0571
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0565
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0565
6149	Solute carrier family 22 member 10	SLC22A10	0.0565
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0564
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0539
566	Serotransferrin	TF	0.0538
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0523
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.052
563	Thyroid peroxidase	TPO	0.0501
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0501
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0484
6151	Monocarboxylate transporter 10	SLC16A10	0.0462
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0459
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0446
558	Solute carrier family 12 member 1	SLC12A1	0.0444
833	Organic cation/carnitine transporter 1	SLC22A4	0.0443
290	Prostaglandin G/H synthase 2	PTGS2	0.0432
756	Sex hormone-binding globulin	SHBG	0.0418
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0412
871	Glucocorticoid receptor	NR3C1	0.0385
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0375
70	Type-1 angiotensin II receptor	AGTR1	0.0375
492	Histamine H1 receptor	HRH1	0.0356
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0352
6147	Solute carrier family 22 member 3	SLC22A3	0.0331
6106	Cytochrome P450 2C18	CYP2C18	0.0328
295	Carbonic anhydrase 1	CA1	0.0328
3810	Catechol O-methyltransferase	COMT	0.0316
731	HIV-1 protease	HIV-1 protease	0.0316
952	Dipeptidyl peptidase 4	DPP4	0.0307
380	Cytochrome P450 17A1	CYP17A1	0.0284
275	Arachidonate 5-lipoxygenase	ALOX5	0.0283
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0275
556	Alpha-1A adrenergic receptor	ADRA1A	0.0273
357	Carbonic anhydrase 2	CA2	0.0262
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0262
4604	Liver carboxylesterase 1	CES1	0.0259
146	Androgen receptor	AR	0.0259
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0251
468	Cytochrome P450 4A11	CYP4A11	0.0247
592	Carbonic anhydrase 4	CA4	0.0246
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0242
29	Tubulin beta-1 chain	TUBB1	0.0238
869	Estrogen receptor beta	ESR2	0.0236
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0234
6031	Cytochrome P450 3A43	CYP3A43	0.0226
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0225
260	Cytochrome P450 51	ERG11	0.0222
761	Cytochrome P450 51	ERG11	0.0222
3163	Cytochrome P450 51	cyp51	0.0222
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.022
6020	Aldehyde oxidase	AOX1	0.0209
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0207
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0203
6085	Fatty acid-binding protein, intestinal	FABP2	0.0203
683	Potassium transporter	GK0582	0.0203
244	Angiotensin-converting enzyme	ACE	0.0201
672	Prostaglandin F2-alpha receptor	PTGFR	0.02
3932	Glutathione S-transferase A2	GSTA2	0.0198
824	Sodium-dependent serotonin transporter	SLC6A4	0.0197
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0196
6137	Multidrug resistance-associated protein 6	ABCC6	0.0195
1405	Thiopurine S-methyltransferase	TPMT	0.0194
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0194
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0193
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0191
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0191
3923	Cholinesterase	BCHE	0.0189
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0189
318	Alpha-2A adrenergic receptor	ADRA2A	0.0187
831	D(2) dopamine receptor	DRD2	0.0179
3947	Xanthine dehydrogenase/oxidase	XDH	0.0174
5818	Folate receptor alpha	FOLR1	0.0173
2539	Tubulin alpha-1 chain	TUBA4A	0.0173
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0173
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0165
124	Histamine H2 receptor	HRH2	0.0163
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0163
887	DNA gyrase subunit B	gyrB	0.0162
4150	DNA gyrase subunit B	gyrB	0.0162
6225	DNA gyrase subunit B	gyrB	0.0162
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0158
3426	Glutamine synthetase	glnA	0.0157
3987	Glutamine synthetase	GLUL	0.0157
6182	Cytochrome P450 2J2	CYP2J2	0.0154
293	Gamma-glutamyl hydrolase	GGH	0.0151
273	Apoptosis regulator Bcl-2	BCL2	0.0151
847	Mu-type opioid receptor	OPRM1	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0145
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0144
737	Mineralocorticoid receptor	NR3C2	0.0143
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0143
904	Glutathione S-transferase P	GSTP1	0.0142
489	Monocarboxylate transporter 2	SLC16A7	0.0141
103	Muscarinic acetylcholine receptor M1	CHRM1	0.014
465	Calmodulin	CALM1	0.0139
49	Endothelin B receptor	EDNRB	0.0139
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0139
3941	Amine oxidase [flavin-containing] A	MAOA	0.0138
161	Tubulin beta chain	TUBB	0.0137
312	Tubulin beta chain	TUB2	0.0137
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0136
1852	Microtubule-associated protein 2	MAP2	0.0135
817	DNA topoisomerase 2-alpha	TOP2A	0.0135
632	Alpha-1B adrenergic receptor	ADRA1B	0.0134
1650	Heme carrier protein 1	SLC46A1	0.0133
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0133
467	Delta-type opioid receptor	OPRD1	0.0132
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0131
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0131
232	Corticosteroid-binding globulin	SERPINA6	0.0131
578	Endothelin-1 receptor	EDNRA	0.0131
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0128
193	Beta-1 adrenergic receptor	ADRB1	0.0127
140	30S ribosomal protein S9	rpsI	0.0127
6719	30S ribosomal protein S9	rpsI	0.0127
6725	30S ribosomal protein S9	rpsI	0.0127
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0126
466	Solute carrier family 12 member 3	SLC12A3	0.0124
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0123
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0122
23	D(1A) dopamine receptor	DRD1	0.0122
24	Thymidylate synthase	TMP1	0.0122
359	Thymidylate synthase	TYMS	0.0122
2626	Thymidylate synthase	thyA	0.0122
2729	Thymidylate synthase	thyA	0.0122
5352	Thymidylate synthase	THYA	0.0122
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.012
4205	Carbonic anhydrase 9	CA9	0.012
3007	Carbonic anhydrase 12	CA12	0.012
469	Annexin A1	ANXA1	0.0119
5923	Microtubule-associated protein tau	MAPT	0.0119
5924	Microtubule-associated protein 4	MAP4	0.0119
614	Progesterone receptor	PGR	0.0119
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
159	Penicillin-binding protein 2B	penA	0.0119
6121	Penicillin-binding protein 2B	penA	0.0119
3270	Elongation factor G	fusA	0.0119
2808	Chloramphenicol acetyltransferase 3	cat3	0.0119
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0119
766	Beta-2 adrenergic receptor	ADRB2	0.0118
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0118
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0118
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0117
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0116
284	DNA-directed RNA polymerase beta chain	rpoB	0.0115
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0115
2016	Dipeptidase 1	DPEP1	0.0115
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0115
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0114
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0114
365	Dihydrofolate reductase	DHFR	0.0114
2381	Dihydrofolate reductase	DFR1	0.0114
2833	Dihydrofolate reductase	Not Available	0.0114
2931	Dihydrofolate reductase	folA	0.0114
3544	Dihydrofolate reductase	folA	0.0114
3682	Dihydrofolate reductase	folA	0.0114
6642	Dihydrofolate reductase	folA	0.0114
6756	Dihydrofolate reductase	dfrA	0.0114
696	Kappa-type opioid receptor	OPRK1	0.0114
407	Vascular endothelial growth factor receptor 2	KDR	0.0113
338	DNA polymerase	UL30	0.0112
379	DNA polymerase	UL54	0.0112
697	DNA polymerase	ORF28	0.0112
2482	DNA polymerase	43	0.0112
4104	DNA polymerase	BALF5	0.0112
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0112
500	Monocarboxylate transporter 4	SLC16A3	0.0111
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0109
22	30S ribosomal protein S4	rpsD	0.0109
6714	30S ribosomal protein S4	rpsD	0.0109
1010	Cytochrome P450 51A1	CYP51A1	0.0109
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0109
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0108
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0107
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0105
1792	Tissue-type plasminogen activator	PLAT	0.0104
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0104
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0104
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0104
26	Vascular endothelial growth factor receptor 3	FLT4	0.0103
3809	Estrogen-related receptor gamma	ESRRG	0.0102
6220	Aryl hydrocarbon receptor	AHR	0.01
634	Squalene monooxygenase	SQLE	0.01
7196	Squalene monooxygenase	ERG1	0.01
4120	NADPH--cytochrome P450 reductase	POR	0.0099
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0099
581	Cytochrome P450 2R1	CYP2R1	0.0099
32	Vascular endothelial growth factor receptor 1	FLT1	0.0098
5650	NimA-related protein	DR_0842	0.0098
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0097
789	Alpha-1D adrenergic receptor	ADRA1D	0.0097
504	Mast/stem cell growth factor receptor	KIT	0.0096
4237	50S ribosomal protein L22	rplV	0.0094
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
856	Vitamin D3 receptor	VDR	0.0093
5934	Cytochrome P450 26A1	CYP26A1	0.0092
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0092
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0091
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0091
645	Penicillin-binding protein 1A	mrcA	0.0091
5805	Penicillin-binding protein 1A	ponA	0.0091
6185	Penicillin-binding protein 1A	mrcA	0.0091
6799	Penicillin-binding protein 1A	pbpA	0.0091
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.009
274	Muscarinic acetylcholine receptor M5	CHRM5	0.009
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.009
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.009
2449	Tubulin alpha-3 chain	TUBA1A	0.0089
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0088
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0088
2391	Ferrochelatase	hemH	0.0087
6502	Ferrochelatase	DKFZp686P18130	0.0087
1591	Ferrochelatase, mitochondrial	FECH	0.0087
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0086
84	Nuclear receptor 0B1	NR0B1	0.0086
543	Penicillin-binding protein 1B	mrcB	0.0086
6186	Penicillin-binding protein 1B	ponB	0.0086
6822	Penicillin-binding protein 1b	pbp1b	0.0086
6844	Penicillin-binding protein 1b	pbp1b	0.0086
818	50S ribosomal protein L10	rplJ	0.0085
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0084
6014	Cytochrome P450 2A13	CYP2A13	0.0084
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0083
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0083
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0083
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0083
6218	Pannexin-1	PANX1	0.0082
4238	50S ribosomal protein L4	rplD	0.0082
5578	50S ribosomal protein L4	rplD	0.0082
6173	50S ribosomal protein L4	rplD	0.0082
6219	50S ribosomal protein L4	rplD	0.0082
1992	Vitamin D-binding protein	GC	0.0082
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0082
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0081
5880	Thrombopoietin receptor	MPL	0.0081
527	Prostacyclin receptor	PTGIR	0.0081
1353	DNA topoisomerase 1	TOP1	0.0081
3552	DNA topoisomerase 1	topA	0.0081
1192	Sulfotransferase 1A1	SULT1A1	0.008
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0079
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0079
860	Nicotinamide N-methyltransferase	NNMT	0.0078
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0078
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
699	Nicotinic acid receptor 1	GPR109A	0.0078
928	Nicotinic acid receptor 2	GPR109B	0.0078
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0078
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0077
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0077
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0075
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0075
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0075
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0075
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0075
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0075
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0075
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0075
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0075
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0075
6559	Cytochrome c oxidase subunit 2	ctaC	0.0075
6669	Cytochrome c oxidase subunit 2	ctaC	0.0075
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0075
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0075
6558	Cytochrome c oxidase subunit 1	ctaD	0.0075
3856	Fibroblast growth factor receptor 3	FGFR3	0.0075
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0074
131	Synaptic vesicular amine transporter	SLC18A2	0.0074
629	Alpha-2B adrenergic receptor	ADRA2B	0.0074
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0073
844	Epidermal growth factor receptor	EGFR	0.0073
474	Acetylcholinesterase	ACHE	0.0073
6168	Solute carrier family 22 member 16	SLC22A16	0.0073
751	Potassium channel subfamily K member 6	KCNK6	0.0073
5626	Nucleoside diphosphate kinase B	NME2	0.0072
122	P2Y purinoceptor 12	P2RY12	0.0072
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0072
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0071
638	D(3) dopamine receptor	DRD3	0.0071
438	Taste receptor type 1 member 2	TAS1R2	0.0071
768	FK506-binding protein 1A	FKBP1A	0.007
2021	Thrombomodulin	THBD	0.007
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0069
713	Sodium-dependent dopamine transporter	SLC6A3	0.0069
2540	Choloylglycine hydrolase	cbh	0.0069
7	Nitric oxide synthase, inducible	NOS2	0.0068
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0068
3014	Ribonuclease UK114	HRSP12	0.0068
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0067
5428	Replication protein	repA	0.0067
3617	Non-heme chloroperoxidase	cpo	0.0067
5426	Non-heme chloroperoxidase	cpo	0.0067
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0067
3018	HTH-type transcriptional regulator malT	malT	0.0067
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0067
172	Potassium channel subfamily K member 1	KCNK1	0.0067
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0066
633	Penicillin-binding proteins 1A/1B	pbpA	0.0065
3686	Acyl-CoA thioesterase I precursor	tesA	0.0065
6501	Fatty acid-binding protein, liver	FABP1	0.0065
1629	Transcription factor AP-1	JUN	0.0064
6033	High affinity interleukin-8 receptor A	CXCR1	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0063
378	Alpha-2C adrenergic receptor	ADRA2C	0.0063
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0062
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0061
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0061
185	Vasopressin V1a receptor	AVPR1A	0.006
1630	Integrin beta-2	ITGB2	0.0059
5294	Nucleoside diphosphate kinase A	NME1	0.0059
1517	Beta-3 adrenergic receptor	ADRB3	0.0059
6211	Tubulin epsilon chain	TUBE1	0.0059
6212	Tubulin gamma-1 chain	TUBG1	0.0059
6210	Tubulin delta chain	TUBD1	0.0059
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0059
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0058
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0058
2958	Probable tautomerase ydcE	pptA	0.0058
2573	Cocaine esterase	cocE	0.0058
7263	Cocaine esterase	Not Available	0.0058
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0058
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0058
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0057
3115	Ras-related protein Rab-9	RAB9A	0.0057
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0057
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
6043	Putative G-protein coupled receptor 44	GPR44	0.0056
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0056
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0056
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0055
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0055
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0055
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0055
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0055
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0055
2599	Tyrosine-protein kinase HCK	HCK	0.0054
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0054
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0054
477	DNA topoisomerase 4 subunit A	parC	0.0054
886	DNA topoisomerase 4 subunit A	parC	0.0054
6226	DNA topoisomerase 4 subunit A	parC	0.0054
6500	Phospholipase A2	PLA2G1B	0.0054
5353	Glutamate decarboxylase alpha	gadA	0.0054
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0053
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0053
404	DNA gyrase subunit A	gyrA	0.0053
6224	DNA gyrase subunit A	gyrA	0.0053
663	Solute carrier family 12 member 4	SLC12A4	0.0053
53	Solute carrier family 12 member 5	SLC12A5	0.0053
6824	Tyrosine-protein kinase Lyn	LYN	0.0052
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0052
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0052
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0052
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0052
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0051
1757	Myeloperoxidase	MPO	0.0051
716	5-hydroxytryptamine 7 receptor	HTR7	0.0051
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0051
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0051
4122	Histone deacetylase 2	HDAC2	0.0051
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.005
777	Tumor necrosis factor	TNF	0.005
517	Alcohol dehydrogenase 1C	ADH1C	0.005
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.005
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.005
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.005
310	Solute carrier family 12 member 2	SLC12A2	0.0049
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
6837	Serine/threonine-protein kinase 17B	STK17B	0.0049
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0049
6044	Serum paraoxonase/lactonase 3	PON3	0.0048
165	FL cytokine receptor	FLT3	0.0048
1525	Heparin-binding growth factor 2	FGF2	0.0048
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0048
1867	Major prion protein	PRNP	0.0047
1291	cAMP response element-binding protein	CREB1	0.0047
3939	Amine oxidase [flavin-containing] B	MAOB	0.0047
267	Plasminogen activator inhibitor 1	SERPINE1	0.0047
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0047
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0046
551	Carnitine O-acetyltransferase	CRAT	0.0046
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0046
332	Beta-lactamase	blaZ	0.0046
2478	Beta-lactamase	ampC	0.0046
2613	Beta-lactamase	ampC	0.0046
2635	Beta-lactamase	ampC	0.0046
2700	Beta-lactamase	penP	0.0046
5445	Beta-lactamase	blaB	0.0046
6019	Beta-lactamase	SHV-7	0.0046
6701	Beta-lactamase	cphA	0.0046
4210	Toll-like receptor 4	TLR4	0.0046
1760	Aminopeptidase N	ANPEP	0.0046
6843	Aminopeptidase N	pepN	0.0046
68	Cannabinoid receptor 1	CNR1	0.0045
2216	Fibroblast growth factor receptor 4	FGFR4	0.0045
572	Integrin alpha-L	ITGAL	0.0045
2693	Heat-labile enterotoxin B chain	eltB	0.0044
811	Translocator protein	TSPO	0.0044
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0044
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0044
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0044
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0044
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0044
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0044
5787	Angiopoietin-1 receptor	TEK	0.0044
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0044
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0044
6645	D-amino-acid oxidase	DAO	0.0043
432	D(4) dopamine receptor	DRD4	0.0043
130	Prostacyclin synthase	PTGIS	0.0043
6221	Steroid hormone receptor ERR1	ESRRA	0.0043
4192	DNA topoisomerase 2-beta	TOP2B	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0043
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0042
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0042
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0042
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1656	CYP2B protein	CYP2B	0.0041
6209	30S ribosomal protein S19	rpsS	0.0041
6712	30S ribosomal protein S19	rpsS	0.0041
6726	30S ribosomal protein S19	rpsS	0.0041
6207	30S ribosomal protein S14	rpsN	0.0041
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.004
814	Ryanodine receptor 1	RYR1	0.0039
5482	Sialidase-2	NEU2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
3685	Catabolite gene activator	crp	0.0038
4655	Adenylate cyclase	cyaC	0.0038
4759	Adenylate cyclase	cyaB2	0.0038
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0038
823	Fibroblast growth factor receptor 2	FGFR2	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0036
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0036
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0036
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0035
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0035
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0035
183	Vascular endothelial growth factor A	VEGFA	0.0035
6171	Solute carrier family 28 member 3	SLC28A3	0.0035
115	Penicillin-binding protein 2	mrdA	0.0035
6069	Penicillin-binding protein 2	mrdA	0.0035
6118	Penicillin-binding protein 2	penA	0.0035
6187	Penicillin-binding protein 2	pbpA	0.0035
6686	Penicillin-binding protein 2	pbp2	0.0035
6939	Penicillin-binding protein 2	mrdA	0.0035
7163	Penicillin-binding protein 2	pbpA	0.0035
509	Thymidine kinase	TK	0.0035
570	Thymidine kinase	TK	0.0035
2559	Thymidine kinase	TK	0.0035
3430	Thymidine kinase	tdk	0.0035
3518	Thymidine kinase	TK	0.0035
5301	Thymidine kinase	tdk	0.0035
5771	Thymidine kinase	ORF36	0.0035
7009	Thymidine kinase	ORF36	0.0035
939	50S ribosomal protein L3	rplC	0.0035
976	Platelet glycoprotein IX	GP9	0.0034
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0033
2249	Aspartate aminotransferase	aspC	0.0033
2671	Aspartate aminotransferase	aspC	0.0033
5490	Aspartate aminotransferase	Not Available	0.0033
4760	Mll3241 protein	mll3241	0.0032
1	Peptidoglycan synthetase ftsI	ftsI	0.0032
4155	Peptidoglycan synthetase ftsI	ftsI	0.0032
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0032
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0032
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0031
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0031
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
239	Coagulation factor X	F10	0.003
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.003
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0029
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0029
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0029
6042	Prostaglandin reductase 2	PTGR2	0.0029
4217	Telomerase reverse transcriptase	TERT	0.0029
1198	Serum paraoxonase/arylesterase 1	PON1	0.0029
6223	Penicillin-binding protein 1C	pbpC	0.0029
319	Opioid receptor, sigma 1	OPRS1	0.0028
571	Melatonin receptor type 1A	MTNR1A	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
362	Melatonin receptor type 1B	MTNR1B	0.0028
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0028
163	D(1B) dopamine receptor	DRD5	0.0028
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0028
65	Matrix metalloproteinase-9	Not Available	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
5126	Arginase	rocF	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2300	Lysozyme	E	0.0027
3633	Lysozyme	R	0.0027
5597	Lysozyme	17	0.0027
867	Penicillin-binding protein 3	pbpC	0.0027
6119	Penicillin-binding protein 3	pbp3	0.0027
7154	Penicillin-binding protein 3	pbp3	0.0027
7157	Penicillin-binding protein 3	LMHCC_2184	0.0027
7162	Penicillin-binding protein 3	pbpB	0.0027
7172	Penicillin-binding protein 3	pbp3	0.0027
1654	Interleukin-1 beta	IL1B	0.0026
484	Tyrosine-protein kinase ABL2	ABL2	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0026
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0026
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0026
5300	Antigen peptide transporter 1	TAP1	0.0026
1178	Adenosine A2a receptor	ADORA2A	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
427	Substance-P receptor	TACR1	0.0026
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0025
760	Fibroblast growth factor 1	FGF1	0.0024
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0024
340	Apoptotic protease-activating factor 1	APAF1	0.0024
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
921	Glutamate receptor 2	GRIA2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
2320	Thymidine kinase, cytosolic	TK1	0.0023
1313	Lactoylglutathione lyase	GLO1	0.0023
5682	Ribonuclease pancreatic	RNASE1	0.0023
6102	Arylamine N-acetyltransferase 2	NAT2	0.0022
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
4773	Deoxycytidine kinase	DCK	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
494	Caspase-1	CASP1	0.0022
3830	Calreticulin	CALR	0.0022
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0022
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0022
825	Arsenical pump-driving ATPase	ASNA1	0.0022
3435	Arsenical pump-driving ATPase	arsA	0.0022
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0021
154	AFG3-like protein 2	AFG3L2	0.0021
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0021
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0021
733	Activin receptor type 1B	ACVR1B	0.0021
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0021
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0021
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0021
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0021
395	ALK tyrosine kinase receptor	Not Available	0.0021
1050	Bile salt sulfotransferase	SULT2A1	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1507	Cytochrome c	CYCS	0.0021
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0021
6432	Transporter	snf	0.002
4203	Histamine N-methyltransferase	HNMT	0.002
780	Retinoic acid receptor RXR-gamma	RXRG	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
292	Activin receptor type-1	ACVR1	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
849	Activated CDC42 kinase 1	TNK2	0.002
3760	Penicillin-binding protein 5 precursor	dacA	0.0019
291	Nitric-oxide synthase, endothelial	NOS3	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
54	Prothrombin	F2	0.0019
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0019
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0019
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0019
297	Adenylate cyclase type 1	ADCY1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
88	Retinoic acid receptor RXR-beta	RXRB	0.0019
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0019
2077	Caspase-3	CASP3	0.0018
2112	Toll-like receptor 9	TLR9	0.0018
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
76	Nitric-oxide synthase, brain	NOS1	0.0018
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
1618	High affinity nerve growth factor receptor	NTRK1	0.0017
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0017
16	Adenosine A1 receptor	ADORA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
819	Penicillin-binding protein 4	dacB	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
6174	50S ribosomal protein L32	rpmF	0.0016
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0016
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0016
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0016
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
1123	Eosinophil cationic protein	RNASE3	0.0016
740	Argininosuccinate synthase	ASS1	0.0016
865	Argininosuccinate synthase	ASS1	0.0016
2680	Argininosuccinate synthase	argG	0.0016
3194	Argininosuccinate synthase	argG	0.0016
1039	Histone deacetylase 9	HDAC9	0.0016
173	Toll-like receptor 7	TLR7	0.0016
661	ADP/ATP translocase 1	SLC25A4	0.0016
6021	Adenosine kinase	ADK	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6755	Poliovirus receptor	PVR	0.0015
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0015
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1541	Metalloproteinase	mmp20	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0014
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0014
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0014
4992	Cytochrome c peroxidase	Not Available	0.0013
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
5590	N utilization substance protein B homolog	nusB	0.0012
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0012
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0012
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0012
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0012
2838	Ribose-5-phosphate isomerase A	rpiA	0.0012
2952	Ribose-5-phosphate isomerase A	rpiA	0.0012
5595	Ribose-5-phosphate isomerase A	rpiA	0.0012
4695	UPF0124 protein yfiH	yfiH	0.0012
5060	Intron-associated endonuclease 1	ITEVIR	0.0012
5593	Transferase	Not Available	0.0012
5588	Cell division protein FtsY	TM_0570	0.0012
5591	Complement component C8 gamma chain	C8G	0.0012
5587	Iron(III)-binding periplasmic protein	fbpA	0.0012
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0012
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0012
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0012
5581	Beta-fructosidase	bfrA	0.0012
5600	Pyruvate decarboxylase	pdc	0.0012
4375	Glutamine synthetase 1	glnA1	0.0012
5575	Short tail fiber protein	12	0.0012
5580	Hexon protein	PII	0.0012
5574	Invasin	YPTB1668	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
1295	Fatty acid synthase	FASN	0.0012
3957	Adenosine deaminase	ADA	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
6859	Protein S100-A4	S100A4	0.0012
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0012
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0012
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
4311	tRNA	TRDMT1	0.0011
4325	tRNA	trmD	0.0011
4328	tRNA	trmD	0.0011
5006	RNASE4 protein	RNASE4	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
5328	Prostaglandin F synthase	Tb11.02.2310	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
908	Glutathione S-transferase theta-1	GSTT1	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.001
1063	Signal transducer and activator of transcription 5B	STAT5B	0.001
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2603	Beta-lactamase II	blm	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2149	Angiogenin	ANG	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
3583	6-phosphogluconolactonase	pgl	0.001
857	Malate dehydrogenase, mitochondrial	MDH2	0.001
162	Retinoic acid receptor gamma-1	RARG	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
174	Sigma 1-type opioid receptor	SIGMAR1	0.0009
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0009
2942	Sialidase	nanH	0.0009
3546	Sialidase	nedA	0.0009
3486	Fumarate hydratase class II	fumC	0.0009
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0009
2286	Isocitrate dehydrogenase [NADP]	icd	0.0009
2302	Isocitrate dehydrogenase [NADP]	icd	0.0009
2771	Isocitrate dehydrogenase [NADP]	icd	0.0009
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0009
164	Histamine H4 receptor	HRH4	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
2697	Uridine-cytidine kinase 2	UCK2	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
411	Glycine N-methyltransferase	GNMT	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
128	Adenine phosphoribosyltransferase	APRT	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
1864	RET proto-oncogene	RET	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6146	High affinity copper uptake protein 1	SLC31A1	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2207	Rhodopsin	RHO	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
3937	Fatty-acid amide hydrolase	FAAH	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
822	Aldose reductase	AKR1B1	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
2802	Endoglucanase G	celCCG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00390 - Digoxin

Targets

Enzymes

Transporters

Predictions