DT-Web

DB00997 - Doxorubicin


Identification
Name Doxorubicin
Accession Number DB00997 (APRD00185)
Type small molecule
Description Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 543.5193
Groups approved
Monoisotopic Weight 543.174060775
Pharmacology
Indication Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms' tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin's disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.
Mechanism of action Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Absorption Not Available
Protein binding Doxorubicin and its major metabolite, doxorubicinol, is 74-76% bound to plasma protein. The extent to binding is independent of plasma concentration up to 1.1 mcg/mL. Doxorubicin does not cross the blood brain barrier.
Biotransformation Doxorubicin is capable of undergoing 3 metabolic routes: one-electron reduction, two-electron reduction, and deglycosidation. However, approximately half of the dose is eliminated from the body unchanged. Two electron reduction yields doxorubicinol, a secondary alcohol. This pathway is considered the primary metabolic pathway. The one electron reduction is facilitated by several oxidoreductases to form a doxirubicin-semiquinone radical. These enzymes include mitochondrial and cystolic NADPH dehydrogenates, xanthine oxidase, and nitric oxide synthases. Deglycosidation is a minor metabolic pathway (1-2% of the dose undergoes this pathway). The resultant metabolites are deoxyaglycone or hydroxyaglycone formed via reduction or hydrolysis respectively. Enzymes that may be involved with this pathway include xanthine oxidase, NADPH-cytochrome P450 reductase, and cytosolic NADPH dehydrogenase.
Route of elimination 40% of the dose appears in bile in 5 days. 5-12% of the drug and its metabolites appears in urine during the same time period. <3% of the dose recovered in urine was doxorubicinol.
Toxicity LD50=21800 ug/kg (rat, subcutaneous)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Dabigatran etexilate P-Glycoprotein inducers such as doxorubicin may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Digoxin The antineoplasic agent decreases the effect of digoxin
Telithromycin Telithromycin may reduce clearance of Doxorubicin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Doxorubicin if Telithromycin is initiated, discontinued or dose changed.
Terbinafine Terbinafine may reduce the metabolism and clearance of Doxorubicin. Consider alternate therapy or monitor for therapeutic/adverse effects of Doxorubicin if Terbinafine is initiated, discontinued or dose changed.
Trastuzumab Trastuzumab may increase the cardiotoxicity of Doxorubicin. Signs and symptoms of cardiac dysfunction should be monitored for frequently. Increased risk of heart failure. Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of doxorubicin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxorubicin if voriconazole is initiated, discontinued or dose changed.
Zidovudine Additive myelosuppression may occur. Doxorubicin may decrease the efficacy of zidovudine. Concomitant therapy should be avoided.
Food Interactions
  • Liberal fluid intake to increase urine output and help the excretion of uric acid.

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions intercalation
References
  • Fornari FA, Randolph JK, Yalowich JC, Ritke MK, Gewirtz DA: Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Mol Pharmacol. 1994 Apr;45(4):649-56. - Pubmed
  • Momparler RL, Karon M, Siegel SE, Avila F: Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Cancer Res. 1976 Aug;36(8):2891-5. - Pubmed
  • Frederick CA, Williams LD, Ughetto G, van der Marel GA, van Boom JH, Rich A, Wang AH: Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin. Biochemistry. 1990 Mar 13;29(10):2538-49. - Pubmed
DTHybrid score Not Available
DNA topoisomerase 2-alpha
Name DNA topoisomerase 2-alpha
Gene Name TOP2A
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Rody A, Karn T, Gatje R, Ahr A, Solbach C, Kourtis K, Munnes M, Loibl S, Kissler S, Ruckhaberle E, Holtrich U, von Minckwitz G, Kaufmann M: Gene expression profiling of breast cancer patients treated with docetaxel, doxorubicin, and cyclophosphamide within the GEPARTRIO trial: HER-2, but not topoisomerase II alpha and microtubule-associated protein tau, is highly predictive of tumor response. Breast. 2007 Feb;16(1):86-93. Epub 2006 Sep 28. - Pubmed
  • Koehn H, Magan N, Isaacs RJ, Stowell KM: Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin. Anticancer Drugs. 2007 Apr;18(4):419-25. - Pubmed
  • Hayashi S, Hatashita M, Matsumoto H, Shioura H, Kitai R, Kano E: Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction. Int J Mol Med. 2006 Nov;18(5):909-15. - Pubmed
  • Azarova AM, Lyu YL, Lin CP, Tsai YC, Lau JY, Wang JC, Liu LF: From the Cover: Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11014-9. Epub 2007 Jun 19. - Pubmed
  • Menendez JA, Vellon L, Lupu R: DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes. Int J Mol Med. 2006 Dec;18(6):1081-7. - Pubmed
DTHybrid score 0.5763

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lu H, Chen CS, Waxman DJ: Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer. Cancer Gene Ther. 2009 May;16(5):393-404. Epub 2008 Nov 14. - Pubmed
DTHybrid score 0.8117
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5752
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Masek V, Anzenbacherova E, Etrych T, Strohalm J, Ulbrich K, Anzenbacher P: Interaction of HPMA copolymer-doxorubicin conjugates with human liver microsomal cytochromes P450. Comparison with free doxorubicin. Drug Metab Dispos. 2011 Jun 3. - Pubmed
DTHybrid score 0.414
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3464
Carbonyl reductase [NADPH] 1
Name Carbonyl reductase [NADPH] 1
Gene Name CBR1
Actions substrate
References
  • Kassner N, Huse K, Martin HJ, Godtel-Armbrust U, Metzger A, Meineke I, Brockmoller J, Klein K, Zanger UM, Maser E, Wojnowski L: Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver. Drug Metab Dispos. 2008 Oct;36(10):2113-20. doi: 10.1124/dmd.108.022251. Epub 2008 Jul 17. - Pubmed
DTHybrid score 0.7697
Carbonyl reductase [NADPH] 3
Name Carbonyl reductase [NADPH] 3
Gene Name Not Available
Actions substrate
References
  • Bains OS, Karkling MJ, Lubieniecka JM, Grigliatti TA, Reid RE, Riggs KW: Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism. J Pharmacol Exp Ther. 2010 Mar;332(3):755-63. doi: 10.1124/jpet.109.160614. Epub 2009 Dec 9. - Pubmed
DTHybrid score Not Available
Alcohol dehydrogenase [NADP+]
Name Alcohol dehydrogenase [NADP+]
Gene Name AKR1A1
Actions substrate
References
  • Kassner N, Huse K, Martin HJ, Godtel-Armbrust U, Metzger A, Meineke I, Brockmoller J, Klein K, Zanger UM, Maser E, Wojnowski L: Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver. Drug Metab Dispos. 2008 Oct;36(10):2113-20. doi: 10.1124/dmd.108.022251. Epub 2008 Jul 17. - Pubmed
DTHybrid score 0.334
Aldo-keto reductase family 1 member C3
Name Aldo-keto reductase family 1 member C3
Gene Name AKR1C3
Actions substrate
References
  • Novotna R, Wsol V, Xiong G, Maser E: Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3. Toxicol Lett. 2008 Sep;181(1):1-6. doi: 10.1016/j.toxlet.2008.06.858. Epub 2008 Jun 21. - Pubmed
DTHybrid score 0.6795
NAD(P)H dehydrogenase [quinone] 1
Name NAD(P)H dehydrogenase [quinone] 1
Gene Name NQO1
Actions substrate
References
  • Pawlowska J, Tarasiuk J, Wolf CR, Paine MJ, Borowski E: Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. - Pubmed
  • Niitsu N, Kasukabe T, Yokoyama A, Okabe-Kado J, Yamamoto-Yamaguchi Y, Umeda M, Honma Y: Anticancer derivative of butyric acid (Pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity. Mol Pharmacol. 2000 Jul;58(1):27-36. - Pubmed
DTHybrid score 0.8802
Xanthine dehydrogenase/oxidase
Name Xanthine dehydrogenase/oxidase
Gene Name XDH
Actions substrate
References
  • Pawlowska J, Tarasiuk J, Wolf CR, Paine MJ, Borowski E: Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. - Pubmed
  • Niitsu N, Kasukabe T, Yokoyama A, Okabe-Kado J, Yamamoto-Yamaguchi Y, Umeda M, Honma Y: Anticancer derivative of butyric acid (Pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity. Mol Pharmacol. 2000 Jul;58(1):27-36. - Pubmed
DTHybrid score 0.6181
Nitric-oxide synthase, brain
Name Nitric-oxide synthase, brain
Gene Name NOS1
Actions substrate
References
  • Vasquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B: Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry. 1997 Sep 23;36(38):11293-7. - Pubmed
  • Fogli S, Nieri P, Breschi MC: The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J. 2004 Apr;18(6):664-75. - Pubmed
DTHybrid score 1.2226
Nitric oxide synthase, inducible
Name Nitric oxide synthase, inducible
Gene Name NOS2
Actions substrate
References
  • Vasquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B: Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry. 1997 Sep 23;36(38):11293-7. - Pubmed
  • Fogli S, Nieri P, Breschi MC: The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J. 2004 Apr;18(6):664-75. - Pubmed
DTHybrid score 1.5341
Nitric-oxide synthase, endothelial
Name Nitric-oxide synthase, endothelial
Gene Name NOS3
Actions substrate
References
  • Vasquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B: Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry. 1997 Sep 23;36(38):11293-7. - Pubmed
  • Fogli S, Nieri P, Breschi MC: The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J. 2004 Apr;18(6):664-75. - Pubmed
DTHybrid score 1.632
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Gene Name NDUFS2
Actions Not Available
References
  • Pawlowska J, Tarasiuk J, Wolf CR, Paine MJ, Borowski E: Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. - Pubmed
  • Thornalley PJ, Bannister WH, Bannister JV: Reduction of oxygen by NADH/NADH dehydrogenase in the presence of adriamycin. Free Radic Res Commun. 1986;2(3):163-71. - Pubmed
  • Nohl H, Gille L, Staniek K: The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines. Z Naturforsch C. 1998 Mar-Apr;53(3-4):279-85. - Pubmed
DTHybrid score 0.2361
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Gene Name NDUFS3
Actions Not Available
References
  • Pawlowska J, Tarasiuk J, Wolf CR, Paine MJ, Borowski E: Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. - Pubmed
  • Thornalley PJ, Bannister WH, Bannister JV: Reduction of oxygen by NADH/NADH dehydrogenase in the presence of adriamycin. Free Radic Res Commun. 1986;2(3):163-71. - Pubmed
  • Nohl H, Gille L, Staniek K: The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines. Z Naturforsch C. 1998 Mar-Apr;53(3-4):279-85. - Pubmed
DTHybrid score 0.2362
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Gene Name NDUFS7
Actions Not Available
References
  • Pawlowska J, Tarasiuk J, Wolf CR, Paine MJ, Borowski E: Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. - Pubmed
  • Thornalley PJ, Bannister WH, Bannister JV: Reduction of oxygen by NADH/NADH dehydrogenase in the presence of adriamycin. Free Radic Res Commun. 1986;2(3):163-71. - Pubmed
  • Nohl H, Gille L, Staniek K: The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines. Z Naturforsch C. 1998 Mar-Apr;53(3-4):279-85. - Pubmed
DTHybrid score 0.2362
NADPH--cytochrome P450 reductase
Name NADPH--cytochrome P450 reductase
Gene Name POR
Actions substrate
References
  • Gutierrez PL, Gee MV, Bachur NR: Kinetics of anthracycline antibiotic free radical formation and reductive glycosidase activity. Arch Biochem Biophys. 1983 May;223(1):68-75. - Pubmed
DTHybrid score 0.3966

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor,inducer
References
  • Fardel O, Lecureur V, Daval S, Corlu A, Guillouzo A: Up-regulation of P-glycoprotein expression in rat liver cells by acute doxorubicin treatment. Eur J Biochem. 1997 May 15;246(1):186-92. - Pubmed
  • Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res. 2001 Feb;18(2):171-6. - Pubmed
  • Takara K, Tanigawara Y, Komada F, Nishiguchi K, Sakaeda T, Okumura K: Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs. Biol Pharm Bull. 1999 Dec;22(12):1355-9. - Pubmed
  • Jutabha P, Wempe MF, Anzai N, Otomo J, Kadota T, Endou H: Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan;61(1):76-84. Epub 2009 Jul 21. - Pubmed
  • Li D, Jang SH, Kim J, Wientjes MG, Au JL: Enhanced drug-induced apoptosis associated with P-glycoprotein overexpression is specific to antimicrotubule agents. Pharm Res. 2003 Jan;20(1):45-50. - Pubmed
  • Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed
  • Kim S, Kim SS, Bang YJ, Kim SJ, Lee BJ: In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines. Peptides. 2003 Jul;24(7):945-53. - Pubmed
  • Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I: Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8472-6. - Pubmed
  • Kusunoki N, Takara K, Tanigawara Y, Yamauchi A, Ueda K, Komada F, Ku Y, Kuroda Y, Saitoh Y, Okumura K: Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein. Jpn J Cancer Res. 1998 Nov;89(11):1220-8. - Pubmed
  • Li YC, Fung KP, Kwok TT, Lee CY, Suen YK, Kong SK: Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells. Chemotherapy. 2004 Jun;50(2):55-62. - Pubmed
  • Sieczkowski E, Lehner C, Ambros PF, Hohenegger M: Double impact on p-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells. Int J Cancer. 2010 May 1;126(9):2025-35. - Pubmed
  • Bray J, Sludden J, Griffin MJ, Cole M, Verrill M, Jamieson D, Boddy AV: Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. Br J Cancer. 2010 Mar 16;102(6):1003-9. Epub 2010 Feb 23. - Pubmed
  • Tao LY, Liang YJ, Wang F, Chen LM, Yan YY, Dai CL, Fu LW: Cediranib (recentin, AZD2171) reverses ABCB1- and ABCC1-mediated multidrug resistance by inhibition of their transport function. Cancer Chemother Pharmacol. 2009 Oct;64(5):961-9. Epub 2009 Mar 3. - Pubmed
  • Woodahl EL, Crouthamel MH, Bui T, Shen DD, Ho RJ: MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8. Epub 2009 Jan 4. - Pubmed
DTHybrid score 0.7376
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions substrate,inhibitor
References
  • Loe DW, Almquist KC, Cole SP, Deeley RG: ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J Biol Chem. 1996 Apr 19;271(16):9683-9. - Pubmed
  • Godinot N, Iversen PW, Tabas L, Xia X, Williams DC, Dantzig AH, Perry WL 3rd: Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey. Mol Cancer Ther. 2003 Mar;2(3):307-16. - Pubmed
  • Tribull TE, Bruner RH, Bain LJ: The multidrug resistance-associated protein 1 transports methoxychlor and protects the seminiferous epithelium from injury. Toxicol Lett. 2003 Apr 30;142(1-2):61-70. - Pubmed
  • Nunoya K, Grant CE, Zhang D, Cole SP, Deeley RG: Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Drug Metab Dispos. 2003 Aug;31(8):1016-26. - Pubmed
  • Stride BD, Grant CE, Loe DW, Hipfner DR, Cole SP, Deeley RG: Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53. - Pubmed
  • Wong IL, Chan KF, Tsang KH, Lam CY, Zhao Y, Chan TH, Chow LM: Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. J Med Chem. 2009 Sep 10;52(17):5311-22. - Pubmed
  • Tao LY, Liang YJ, Wang F, Chen LM, Yan YY, Dai CL, Fu LW: Cediranib (recentin, AZD2171) reverses ABCB1- and ABCC1-mediated multidrug resistance by inhibition of their transport function. Cancer Chemother Pharmacol. 2009 Oct;64(5):961-9. Epub 2009 Mar 3. - Pubmed
  • Zheng LS, Wang F, Li YH, Zhang X, Chen LM, Liang YJ, Dai CL, Yan YY, Tao LY, Mi YJ, Yang AK, To KK, Fu LW: Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function. PLoS One. 2009;4(4):e5172. Epub 2009 Apr 23. - Pubmed
DTHybrid score 0.4957
Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions inhibitor
References
  • Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed
DTHybrid score 0.3254
Multidrug resistance-associated protein 6
Name Multidrug resistance-associated protein 6
Gene Name ABCC6
Actions substrate,inhibitor
References
  • Cai J, Daoud R, Alqawi O, Georges E, Pelletier J, Gros P: Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). Biochemistry. 2002 Jun 25;41(25):8058-67. - Pubmed
  • Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD: Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. - Pubmed
DTHybrid score 0.3417
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate,inhibitor
References
  • Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y: ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem. 2003 Jun 20;278(25):22644-9. Epub 2003 Apr 7. - Pubmed
  • Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M: Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2003 Jan;63(1):65-72. - Pubmed
  • Ozvegy C, Litman T, Szakacs G, Nagy Z, Bates S, Varadi A, Sarkadi B: Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7. - Pubmed
  • Allen JD, Van Dort SC, Buitelaar M, van Tellingen O, Schinkel AH: Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein. Cancer Res. 2003 Mar 15;63(6):1339-44. - Pubmed
  • An Y, Ongkeko WM: ABCG2: the key to chemoresistance in cancer stem cells? Expert Opin Drug Metab Toxicol. 2009 Dec;5(12):1529-42. - Pubmed
  • Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11. - Pubmed
  • Dai CL, Liang YJ, Wang YS, Tiwari AK, Yan YY, Wang F, Chen ZS, Tong XZ, Fu LW: Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett. 2009 Jun 28;279(1):74-83. Epub 2009 Feb 18. - Pubmed
  • Zheng LS, Wang F, Li YH, Zhang X, Chen LM, Liang YJ, Dai CL, Yan YY, Tao LY, Mi YJ, Yang AK, To KK, Fu LW: Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function. PLoS One. 2009;4(4):e5172. Epub 2009 Apr 23. - Pubmed
DTHybrid score 0.5385
Solute carrier family 22 member 16
Name Solute carrier family 22 member 16
Gene Name SLC22A16
Actions substrate
References
  • Bray J, Sludden J, Griffin MJ, Cole M, Verrill M, Jamieson D, Boddy AV: Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. Br J Cancer. 2010 Mar 16;102(6):1003-9. Epub 2010 Feb 23. - Pubmed
DTHybrid score 0.2716
Multidrug resistance-associated protein 7
Name Multidrug resistance-associated protein 7
Gene Name ABCC10
Actions inhibitor
References
  • Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed
DTHybrid score 0.305
ATP-binding cassette sub-family B member 8, mitochondrial
Name ATP-binding cassette sub-family B member 8, mitochondrial
Gene Name ABCB8
Actions substrate
References
  • Elliott AM, Al-Hajj MA: ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. Mol Cancer Res. 2009 Jan;7(1):79-87. - Pubmed
DTHybrid score 0.2714
Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions substrate
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed
DTHybrid score 0.3589
RalA-binding protein 1
Name RalA-binding protein 1
Gene Name Not Available
Actions substrate
References
  • Singhal SS, Singhal J, Nair MP, Lacko AG, Awasthi YC, Awasthi S: Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25. - Pubmed
DTHybrid score Not Available
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • Folmer Y, Schneider M, Blum HE, Hafkemeyer P: Reversal of drug resistance of hepatocellular carcinoma cells by adenoviral delivery of anti-ABCC2 antisense constructs. Cancer Gene Ther. 2007 Nov;14(11):875-84. Epub 2007 Aug 17. - Pubmed
DTHybrid score 0.5205

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.3755
4200 Cytochrome P450 1A2 CYP1A2 0.3415
4118 Cytochrome P450 3A5 CYP3A5 0.3177
6016 Cytochrome P450 2C19 CYP2C19 0.2961
4924 Cytochrome P450 2C8 CYP2C8 0.2911
6107 Cytochrome P450 3A7 CYP3A7 0.2196
6024 Cytochrome P450 1A1 CYP1A1 0.198
6013 Cytochrome P450 2E1 CYP2E1 0.1811
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1644
477 DNA topoisomerase 4 subunit A parC 0.1585
886 DNA topoisomerase 4 subunit A parC 0.1585
6226 DNA topoisomerase 4 subunit A parC 0.1585
404 DNA gyrase subunit A gyrA 0.1558
6224 DNA gyrase subunit A gyrA 0.1558
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1503
5354 DevB protein VC_A0897 0.138
2164 Multidrug resistance-associated protein 4 ABCC4 0.1345
6144 Solute carrier family 22 member 2 SLC22A2 0.1341
1729 Solute carrier family 22 member 6 SLC22A6 0.1234
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.1221
118 Organic cation/carnitine transporter 2 SLC22A5 0.1219
842 Chloride channel protein 2 CLCN2 0.1214
6142 Solute carrier family 22 member 8 SLC22A8 0.1152
587 Serum albumin ALB 0.1151
5718 Cytochrome P450 2A6 CYP2A6 0.1132
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1032
4192 DNA topoisomerase 2-beta TOP2B 0.0987
6145 Solute carrier family 22 member 1 SLC22A1 0.0983
904 Glutathione S-transferase P GSTP1 0.0968
822 Aldose reductase AKR1B1 0.0951
6141 Sodium/bile acid cotransporter SLC10A1 0.088
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0844
20 Prostaglandin G/H synthase 1 PTGS1 0.0843
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0823
290 Prostaglandin G/H synthase 2 PTGS2 0.0816
833 Organic cation/carnitine transporter 1 SLC22A4 0.0784
831 D(2) dopamine receptor DRD2 0.0776
6143 Solute carrier family 22 member 7 SLC22A7 0.0772
131 Synaptic vesicular amine transporter SLC18A2 0.0704
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0702
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0673
6136 Multidrug resistance-associated protein 5 ABCC5 0.0668
1757 Myeloperoxidase MPO 0.0663
3811 Cytochrome P450 19A1 CYP19A1 0.0663
908 Glutathione S-transferase theta-1 GSTT1 0.0658
468 Cytochrome P450 4A11 CYP4A11 0.0645
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0641
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0617
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0617
556 Alpha-1A adrenergic receptor ADRA1A 0.0611
161 Tubulin beta chain TUBB 0.0607
312 Tubulin beta chain TUB2 0.0607
136 Estrogen receptor ESR1 0.0602
6147 Solute carrier family 22 member 3 SLC22A3 0.0598
4604 Liver carboxylesterase 1 CES1 0.0596
492 Histamine H1 receptor HRH1 0.0596
828 Phenylalanine-4-hydroxylase PAH 0.0587
3109 Phenylalanine-4-hydroxylase phhA 0.0587
6020 Aldehyde oxidase AOX1 0.0585
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0584
6106 Cytochrome P450 2C18 CYP2C18 0.0584
824 Sodium-dependent serotonin transporter SLC6A4 0.0568
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0551
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0551
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0547
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0537
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0532
146 Androgen receptor AR 0.0529
896 Glutathione S-transferase Mu 1 GSTM1 0.0505
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0504
4407 FMN-dependent NADH-azoreductase azoR 0.05
5169 FMN-dependent NADH-azoreductase azoR 0.05
2617 Nitric oxide synthase oxygenase nos 0.0495
2701 Nitric oxide synthase oxygenase nos 0.0495
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0495
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0495
1024 Solute carrier family 22 member 11 SLC22A11 0.0492
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0484
2972 6-deoxyerythronolide B hydroxylase eryF 0.0483
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0478
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0478
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0472
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0467
551 Carnitine O-acetyltransferase CRAT 0.0464
502 5-hydroxytryptamine 2A receptor HTR2A 0.0463
6163 Copper-transporting ATPase 2 ATP7B 0.0459
6165 Copper-transporting ATPase 1 ATP7A 0.0459
731 HIV-1 protease HIV-1 protease 0.0453
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0452
105 Sodium-dependent multivitamin transporter SLC5A6 0.0447
6146 High affinity copper uptake protein 1 SLC31A1 0.0446
3923 Cholinesterase BCHE 0.0444
1353 DNA topoisomerase 1 TOP1 0.0443
3552 DNA topoisomerase 1 topA 0.0443
847 Mu-type opioid receptor OPRM1 0.043
2159 Quinone oxidoreductase CRYZ 0.0426
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0419
713 Sodium-dependent dopamine transporter SLC6A3 0.0413
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0411
2539 Tubulin alpha-1 chain TUBA4A 0.0405
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.04
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.04
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.04
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.04
4079 Lipoic acid synthetase, mitochondrial LIAS 0.0397
45 Lipoyltransferase 1, mitochondrial LIPT1 0.0397
29 Tubulin beta-1 chain TUBB1 0.0391
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0386
176 30S ribosomal protein S10 rpsJ 0.0385
6175 30S ribosomal protein S10 rpsJ 0.0385
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0385
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.0384
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.038
318 Alpha-2A adrenergic receptor ADRA2A 0.0378
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0375
373 Transthyretin TTR 0.0373
672 Prostaglandin F2-alpha receptor PTGFR 0.0371
871 Glucocorticoid receptor NR3C1 0.037
380 Cytochrome P450 17A1 CYP17A1 0.0359
24 Thymidylate synthase TMP1 0.0357
359 Thymidylate synthase TYMS 0.0357
2626 Thymidylate synthase thyA 0.0357
2729 Thymidylate synthase thyA 0.0357
5352 Thymidylate synthase THYA 0.0357
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0356
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0356
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0351
5923 Microtubule-associated protein tau MAPT 0.0347
5924 Microtubule-associated protein 4 MAP4 0.0347
1852 Microtubule-associated protein 2 MAP2 0.0346
315 Arginase-1 ARG1 0.0343
738 Monocarboxylate transporter 1 SLC16A1 0.0342
4773 Deoxycytidine kinase DCK 0.0341
646 Malate dehydrogenase, cytoplasmic MDH1 0.0336
766 Beta-2 adrenergic receptor ADRB2 0.0325
193 Beta-1 adrenergic receptor ADRB1 0.0323
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0321
273 Apoptosis regulator Bcl-2 BCL2 0.032
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0312
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.031
666 NADP-dependent malic enzyme ME1 0.0309
23 D(1A) dopamine receptor DRD1 0.0309
4180 DNA-(apurinic or apyrimidinic site) lyase APEX1 0.0305
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0305
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0304
844 Epidermal growth factor receptor EGFR 0.0303
13 Aminomethyltransferase, mitochondrial AMT 0.0299
465 Calmodulin CALM1 0.0297
6085 Fatty acid-binding protein, intestinal FABP2 0.0295
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0292
320 5-hydroxytryptamine 1A receptor HTR1A 0.029
1629 Transcription factor AP-1 JUN 0.0288
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0287
723 Cytosolic phospholipase A2 PLA2G4A 0.0286
134 Tryptophan 5-hydroxylase 1 TPH1 0.0284
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0283
504 Mast/stem cell growth factor receptor KIT 0.0279
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0273
260 Cytochrome P450 51 ERG11 0.0271
761 Cytochrome P450 51 ERG11 0.0271
3163 Cytochrome P450 51 cyp51 0.0271
365 Dihydrofolate reductase DHFR 0.0268
2381 Dihydrofolate reductase DFR1 0.0268
2833 Dihydrofolate reductase Not Available 0.0268
2931 Dihydrofolate reductase folA 0.0268
3544 Dihydrofolate reductase folA 0.0268
3682 Dihydrofolate reductase folA 0.0268
6642 Dihydrofolate reductase folA 0.0268
6756 Dihydrofolate reductase dfrA 0.0268
654 Flavin reductase BLVRB 0.0267
632 Alpha-1B adrenergic receptor ADRA1B 0.0266
869 Estrogen receptor beta ESR2 0.0264
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.026
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0257
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0257
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0257
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0256
2675 Pteridine reductase 1 PTR1 0.0254
614 Progesterone receptor PGR 0.0254
33 Cystine/glutamate transporter SLC7A11 0.0249
6210 Tubulin delta chain TUBD1 0.0249
6212 Tubulin gamma-1 chain TUBG1 0.0249
6211 Tubulin epsilon chain TUBE1 0.0249
70 Type-1 angiotensin II receptor AGTR1 0.0249
444 Alcohol dehydrogenase 1B ADH1B 0.0249
638 D(3) dopamine receptor DRD3 0.0247
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0247
5626 Nucleoside diphosphate kinase B NME2 0.0245
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0245
327 Glutathione reductase gor 0.0243
5110 Glutathione reductase GR2 0.0243
3917 Methylenetetrahydrofolate reductase MTHFR 0.0242
298 Renin REN 0.0242
467 Delta-type opioid receptor OPRD1 0.0242
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0239
6031 Cytochrome P450 3A43 CYP3A43 0.0238
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0235
590 5-hydroxytryptamine 2C receptor HTR2C 0.0234
816 Biliverdin reductase A BLVRA 0.0229
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0228
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0228
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0228
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0228
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0228
3611 Cytidine deaminase cdd 0.0223
3707 Cytidine deaminase cdd 0.0223
4211 Cytidine deaminase CDA 0.0223
696 Kappa-type opioid receptor OPRK1 0.0222
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0222
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0221
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0221
2449 Tubulin alpha-3 chain TUBA1A 0.022
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.022
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.022
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.022
3932 Glutathione S-transferase A2 GSTA2 0.022
6167 Organic solute transporter subunit beta OSTB 0.0217
6166 Organic solute transporter subunit alpha OSTA 0.0217
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0217
3941 Amine oxidase [flavin-containing] A MAOA 0.0215
6599 HTH-type transcriptional regulator ttgR ttgR 0.0213
63 Malate dehydrogenase mdh 0.0211
2329 Malate dehydrogenase mdh 0.0211
3445 Malate dehydrogenase mdh 0.0211
4420 Malate dehydrogenase mdh 0.0211
4438 Malate dehydrogenase mdh 0.0211
740 Argininosuccinate synthase ASS1 0.021
865 Argininosuccinate synthase ASS1 0.021
2680 Argininosuccinate synthase argG 0.021
3194 Argininosuccinate synthase argG 0.021
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0209
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0209
6220 Aryl hydrocarbon receptor AHR 0.0208
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0208
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0207
702 UMP-CMP kinase CMPK1 0.0207
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0206
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0206
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0206
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0206
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0206
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0206
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0206
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0206
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0206
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0206
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0206
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0206
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0206
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0206
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0206
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0206
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0206
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0206
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0206
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0206
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0206
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0206
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0206
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0206
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0206
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0206
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0206
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0206
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0206
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0206
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0206
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0206
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0206
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0206
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0206
206 3-keto-steroid reductase HSD17B7 0.0206
167 L-lactate dehydrogenase C chain LDHC 0.0206
644 Heme oxygenase 2 HMOX2 0.0206
4982 Heme oxygenase 2 pbsA2 0.0206
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0206
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0206
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0206
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0206
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0206
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0206
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0206
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0206
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0206
107 C-4 methylsterol oxidase SC4MOL 0.0206
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0206
729 GDP-L-fucose synthetase TSTA3 0.0206
3463 GDP-L-fucose synthetase fcl 0.0206
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0206
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0206
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0206
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0206
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0206
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0206
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0206
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0206
3726 D-3-phosphoglycerate dehydrogenase serA 0.0206
4291 D-3-phosphoglycerate dehydrogenase serA 0.0206
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0206
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0206
711 UDP-glucose 6-dehydrogenase UGDH 0.0206
3672 UDP-glucose 6-dehydrogenase hasB 0.0206
643 Peroxisomal bifunctional enzyme EHHADH 0.0206
34 7-dehydrocholesterol reductase DHCR7 0.0206
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0206
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0206
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0206
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0206
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0206
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0206
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0206
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0206
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0206
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0206
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0206
5073 Ferredoxin--NADP reductase petH 0.0206
5076 Ferredoxin--NADP reductase fpr 0.0206
5119 Ferredoxin--NADP reductase petH 0.0206
5121 Ferredoxin--NADP reductase fpr 0.0206
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0204
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0204
1656 CYP2B protein CYP2B 0.0203
683 Potassium transporter GK0582 0.0203
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0201
1650 Heme carrier protein 1 SLC46A1 0.02
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0199
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0198
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0198
864 Gag-Pol polyprotein gag-pol 0.0197
2237 Gag-Pol polyprotein gag-pol 0.0197
2326 Gag-Pol polyprotein gag-pol 0.0197
2451 Gag-Pol polyprotein gag-pol 0.0197
2901 Gag-Pol polyprotein gag-pol 0.0197
3165 Gag-Pol polyprotein gag-pol 0.0197
3722 Gag-Pol polyprotein gag-pol 0.0197
6306 Gag-Pol polyprotein gag-pol 0.0197
6624 Gag-Pol polyprotein gag-pol 0.0197
5294 Nucleoside diphosphate kinase A NME1 0.0197
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0197
810 Heme oxygenase 1 HMOX1 0.0197
3391 Heme oxygenase 1 pbsA1 0.0197
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0196
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0195
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0194
228 Beta platelet-derived growth factor receptor PDGFRB 0.0194
396 Alcohol dehydrogenase 4 ADH4 0.0193
328 Sorbitol dehydrogenase SORD 0.0193
597 Dihydropteridine reductase QDPR 0.0192
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0192
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0192
6171 Solute carrier family 28 member 3 SLC28A3 0.0188
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0188
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0186
676 Tyrosine 3-monooxygenase TH 0.0186
473 L-lactate dehydrogenase A chain LDHA 0.0186
117 Sterol O-acyltransferase 1 SOAT1 0.0185
714 Glutathione reductase, mitochondrial GSR 0.0185
3587 Gastrotropin FABP6 0.0184
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0183
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0182
3270 Elongation factor G fusA 0.0181
569 Retinal dehydrogenase 2 ALDH1A2 0.0181
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.018
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.018
2808 Chloramphenicol acetyltransferase 3 cat3 0.0179
6149 Solute carrier family 22 member 10 SLC22A10 0.0179
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0178
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0177
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0177
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0176
293 Gamma-glutamyl hydrolase GGH 0.0175
77 L-lactate dehydrogenase B chain LDHB 0.0174
992 Protein tyrosine kinase 2 beta PTK2B 0.0174
12 Alcohol dehydrogenase class 3 ADH5 0.0174
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0173
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0173
1405 Thiopurine S-methyltransferase TPMT 0.0172
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0172
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0172
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0172
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0172
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0171
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0171
611 Retinal dehydrogenase 1 ALDH1A1 0.0169
756 Sex hormone-binding globulin SHBG 0.0168
341 5-hydroxytryptamine 3 receptor HTR3A 0.0168
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0168
893 [Citrate [pro-3S]-lyase] ligase citC 0.0168
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0167
4403 Protein iolS iolS 0.0167
5330 General stress protein 69 yhdN 0.0167
5322 Oxidoreductase ydhF ydhF 0.0167
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0167
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0167
5332 MtdA bifunctional protein mtdA 0.0167
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0167
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0167
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0167
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0167
3778 NAD(P) transhydrogenase subunit beta pntB 0.0167
789 Alpha-1D adrenergic receptor ADRA1D 0.0167
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0167
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0167
407 Vascular endothelial growth factor receptor 2 KDR 0.0167
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0167
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0166
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0166
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0166
885 5-hydroxytryptamine 1B receptor HTR1B 0.0165
952 Dipeptidyl peptidase 4 DPP4 0.0165
1814 Protein-arginine deiminase type-4 PADI4 0.0165
517 Alcohol dehydrogenase 1C ADH1C 0.0165
251 Alcohol dehydrogenase 1A ADH1A 0.0164
6026 Alcohol dehydrogenase 6 ADH6 0.0164
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0164
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0164
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0164
3823 Cytokine receptor common gamma chain IL2RG 0.0163
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0163
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0163
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0162
857 Malate dehydrogenase, mitochondrial MDH2 0.0162
275 Arachidonate 5-lipoxygenase ALOX5 0.016
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.016
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0159
627 11-cis retinol dehydrogenase RDH5 0.0159
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0159
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0159
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0159
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0159
626 Cysteine dioxygenase type 1 CDO1 0.0158
887 DNA gyrase subunit B gyrB 0.0156
4150 DNA gyrase subunit B gyrB 0.0156
6225 DNA gyrase subunit B gyrB 0.0156
843 NG,NG-dimethylarginine dimethylaminohydrolase 1 DDAH1 0.0156
670 NG,NG-dimethylarginine dimethylaminohydrolase 2 DDAH2 0.0156
6182 Cytochrome P450 2J2 CYP2J2 0.0156
4068 Protein-arginine deiminase type-2 PADI2 0.0156
4066 Protein-arginine deiminase type-1 PADI1 0.0156
4067 Protein-arginine deiminase type-3 PADI3 0.0156
4065 Protein-arginine deiminase type-6 PADI6 0.0156
26 Vascular endothelial growth factor receptor 3 FLT4 0.0155
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0153
4531 Putative ketoacyl reductase actIII 0.0153
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0152
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0152
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0152
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0152
3939 Amine oxidase [flavin-containing] B MAOB 0.015
32 Vascular endothelial growth factor receptor 1 FLT1 0.0149
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0147
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0147
725 5-hydroxytryptamine 1D receptor HTR1D 0.0147
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0146
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0146
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0145
4582 Putative pteridine reductase 2 ptr2 0.0144
5328 Prostaglandin F synthase Tb11.02.2310 0.0143
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0143
989 L-xylulose reductase DCXR 0.0143
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0143
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0143
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0143
2286 Isocitrate dehydrogenase [NADP] icd 0.0143
2302 Isocitrate dehydrogenase [NADP] icd 0.0143
2771 Isocitrate dehydrogenase [NADP] icd 0.0143
2636 Shikimate dehydrogenase aroE 0.0143
3515 Shikimate dehydrogenase aroE 0.0143
3446 NADP-dependent alcohol dehydrogenase adh 0.0143
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.0142
5787 Angiopoietin-1 receptor TEK 0.0142
724 Interleukin-2 receptor alpha chain IL2RA 0.0142
717 Interleukin-2 receptor subunit beta IL2RB 0.0142
629 Alpha-2B adrenergic receptor ADRA2B 0.0141
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0141
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.014
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0139
49 Endothelin B receptor EDNRB 0.0139
122 P2Y purinoceptor 12 P2RY12 0.0139
1192 Sulfotransferase 1A1 SULT1A1 0.0138
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0138
737 Mineralocorticoid receptor NR3C2 0.0137
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0137
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0136
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0136
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0136
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0135
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0134
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0134
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0133
165 FL cytokine receptor FLT3 0.0133
6043 Putative G-protein coupled receptor 44 GPR44 0.0132
6297 Prostaglandin reductase 1 PTGR1 0.0132
461 Glycine receptor subunit alpha-3 GLRA3 0.0132
6218 Pannexin-1 PANX1 0.0131
3062 Aspartate-semialdehyde dehydrogenase asd 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
4031 Glutathione S-transferase A1 GSTA1 0.0131
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0131
578 Endothelin-1 receptor EDNRA 0.0131
279 Tyrosinase TYR 0.013
4228 Keratin, type II cytoskeletal 7 KRT7 0.013
3307 Acriflavine resistance protein B acrB 0.013
1830 5'-nucleotidase NT5E 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
469 Annexin A1 ANXA1 0.0127
474 Acetylcholinesterase ACHE 0.0126
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0125
378 Alpha-2C adrenergic receptor ADRA2C 0.0125
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0124
1124 Sepiapterin reductase SPR 0.0124
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0124
125 DNA polymerase beta POLB 0.0123
489 Monocarboxylate transporter 2 SLC16A7 0.0122
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0122
436 5-hydroxytryptamine 2B receptor HTR2B 0.0122
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0121
1760 Aminopeptidase N ANPEP 0.012
6843 Aminopeptidase N pepN 0.012
124 Histamine H2 receptor HRH2 0.012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.012
4203 Histamine N-methyltransferase HNMT 0.012
400 Coagulation factor IX F9 0.0118
5461 Coagulation factor IX F9 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0118
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0117
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0117
183 Vascular endothelial growth factor A VEGFA 0.0117
818 50S ribosomal protein L10 rplJ 0.0117
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0115
84 Nuclear receptor 0B1 NR0B1 0.0114
1010 Cytochrome P450 51A1 CYP51A1 0.0113
432 D(4) dopamine receptor DRD4 0.0113
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
6042 Prostaglandin reductase 2 PTGR2 0.0111
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0111
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0111
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.011
604 Vitamin K-dependent protein Z PROZ 0.011
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.011
5818 Folate receptor alpha FOLR1 0.0109
303 Diamine acetyltransferase 2 SAT2 0.0109
623 Spermine oxidase SMOX 0.0109
1317 Spermine synthase SMS 0.0109
2443 Azurin azu 0.0108
1313 Lactoylglutathione lyase GLO1 0.0108
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0108
239 Coagulation factor X F10 0.0107
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0107
2360 Dihydroneopterin aldolase folB 0.0107
342 P protein [Includes: DNA-directed DNA polymerase P 0.0106
612 P protein [Includes: DNA-directed DNA polymerase P 0.0106
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0106
3809 Estrogen-related receptor gamma ESRRG 0.0105
716 5-hydroxytryptamine 7 receptor HTR7 0.0105
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0104
232 Corticosteroid-binding globulin SERPINA6 0.0103
6859 Protein S100-A4 S100A4 0.0103
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0103
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0103
2939 Peptide methionine sulfoxide reductase msrA msrA 0.0102
2888 DNA-repair protein XRCC4 XRCC4 0.0102
2906 Coatomer subunit gamma COPG 0.0102
284 DNA-directed RNA polymerase beta chain rpoB 0.0102
5773 DNA-directed RNA polymerase beta chain rpoB 0.0102
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0102
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0102
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0102
577 Argininosuccinate lyase ASL 0.0101
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.01
1178 Adenosine A2a receptor ADORA2A 0.01
123 Diamine acetyltransferase 1 SAT1 0.01
174 Sigma 1-type opioid receptor SIGMAR1 0.0099
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0099
1245 Vitamin K-dependent protein S PROS1 0.0099
422 Vitamin K-dependent protein C PROC 0.0099
6138 Multidrug resistance protein 3 ABCB4 0.0099
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0098
2981 Phospholipase A2, membrane associated PLA2G2A 0.0098
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0098
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0098
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0098
1569 G1/S-specific cyclin-D1 CCND1 0.0097
605 Fumarate reductase flavoprotein subunit frdA 0.0097
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0097
3673 Fumarate reductase flavoprotein subunit fccA 0.0097
4912 Fumarate reductase flavoprotein subunit ifcA 0.0097
6549 Fumarate reductase flavoprotein subunit frdA 0.0097
4237 50S ribosomal protein L22 rplV 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
4486 Phenol 2-hydroxylase component B pheA2 0.0095
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0095
4477 Dihydrolipoyl dehydrogenase lpdV 0.0095
5077 Dihydrolipoyl dehydrogenase Not Available 0.0095
5117 Dihydrolipoyl dehydrogenase lpd 0.0095
4439 Ferredoxin reductase bphA4 0.0095
3856 Fibroblast growth factor receptor 3 FGFR3 0.0095
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
299 Folate receptor beta FOLR2 0.0093
718 Folate receptor gamma FOLR3 0.0092
804 Mitochondrial folate transporter/carrier SLC25A32 0.0092
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
6228 Nuclear receptor coactivator 1 NCOA1 0.0091
2090 Toll-like receptor 2 TLR2 0.0091
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.009
6241 Nuclear receptor coactivator 2 NCOA2 0.009
2298 Cytochrome P450-cam camC 0.009
834 Arginase-2, mitochondrial ARG2 0.0089
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0089
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0089
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0088
777 Tumor necrosis factor TNF 0.0088
798 Osteocalcin BGLAP 0.0088
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0087
4476 Mannitol dehydrogenase mtlD 0.0087
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0086
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0086
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0086
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0085
4238 50S ribosomal protein L4 rplD 0.0085
5578 50S ribosomal protein L4 rplD 0.0085
6173 50S ribosomal protein L4 rplD 0.0085
6219 50S ribosomal protein L4 rplD 0.0085
4440 NADH peroxidase npr 0.0084
16 Adenosine A1 receptor ADORA1 0.0084
3102 Flavohemoprotein hmp 0.0083
4969 Flavohemoprotein hmp 0.0083
499 Arginine decarboxylase ADC 0.0083
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0083
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0083
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0083
4503 NADPH-flavin oxidoreductase frp 0.0083
814 Ryanodine receptor 1 RYR1 0.0083
905 Glutathione transferase omega-1 GSTO1 0.0082
2433 Capsid protein P40 UL80 0.0082
3569 Capsid protein P40 BVRF2 0.0082
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0082
899 Glutathione S-transferase Mu 3 GSTM3 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
2297 Genome polyprotein Not Available 0.0081
2322 Genome polyprotein Not Available 0.0081
2694 Genome polyprotein Not Available 0.0081
2719 Genome polyprotein Not Available 0.0081
2860 Genome polyprotein Not Available 0.0081
2928 Genome polyprotein Not Available 0.0081
3160 Genome polyprotein Not Available 0.0081
3260 Genome polyprotein Not Available 0.0081
4783 Genome polyprotein Not Available 0.0081
5726 Genome polyprotein Not Available 0.0081
5779 Genome polyprotein Not Available 0.0081
5867 Genome polyprotein Not Available 0.0081
6253 Genome polyprotein Not Available 0.0081
6301 Genome polyprotein Not Available 0.0081
6380 Genome polyprotein Not Available 0.0081
6381 Genome polyprotein Not Available 0.0081
6437 Genome polyprotein Not Available 0.0081
6520 Genome polyprotein Not Available 0.0081
6521 Genome polyprotein Not Available 0.0081
6652 Genome polyprotein Not Available 0.0081
6734 Genome polyprotein Not Available 0.0081
6735 Genome polyprotein Not Available 0.0081
6736 Genome polyprotein Not Available 0.0081
6737 Genome polyprotein Not Available 0.0081
6738 Genome polyprotein Not Available 0.0081
6739 Genome polyprotein Not Available 0.0081
6744 Genome polyprotein Not Available 0.0081
6748 Genome polyprotein Not Available 0.0081
6894 Genome polyprotein Not Available 0.0081
6898 Genome polyprotein Not Available 0.0081
921 Glutamate receptor 2 GRIA2 0.0081
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.008
936 Ephrin type-A receptor 2 EPHA2 0.008
484 Tyrosine-protein kinase ABL2 ABL2 0.008
369 Coagulation factor VII F7 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
1714 Mitogen-activated protein kinase 3 MAPK3 0.0079
6014 Cytochrome P450 2A13 CYP2A13 0.0078
449 Ornithine decarboxylase ODC1 0.0078
1050 Bile salt sulfotransferase SULT2A1 0.0077
58 Cationic amino acid transporter 4 SLC7A4 0.0077
150 Cationic amino acid transporter 3 SLC7A3 0.0077
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
163 D(1B) dopamine receptor DRD5 0.0075
3810 Catechol O-methyltransferase COMT 0.0075
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0074
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0073
2391 Ferrochelatase hemH 0.0072
6502 Ferrochelatase DKFZp686P18130 0.0072
1591 Ferrochelatase, mitochondrial FECH 0.0072
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0072
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0072
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0072
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0072
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0071
68 Cannabinoid receptor 1 CNR1 0.0071
823 Fibroblast growth factor receptor 2 FGFR2 0.0071
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0071
2599 Tyrosine-protein kinase HCK HCK 0.0071
482 Glycine receptor subunit alpha-1 GLRA1 0.0071
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.007
6837 Serine/threonine-protein kinase 17B STK17B 0.007
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
6824 Tyrosine-protein kinase Lyn LYN 0.007
5934 Cytochrome P450 26A1 CYP26A1 0.007
705 Glutamate receptor 1 GRIA1 0.007
2268 Cholesterol oxidase choB 0.007
2822 Cholesterol oxidase choA 0.007
54 Prothrombin F2 0.007
283 SEC14-like protein 2 SEC14L2 0.0069
5122 Mersacidin decarboxylase mrsD 0.0069
5078 Amine oxidase, flavin-containing PSPTO1126 0.0069
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0069
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0069
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0069
526 Thioredoxin reductase trxB 0.0069
3767 Thioredoxin reductase trxB 0.0069
3763 5,10-methylenetetrahydrofolate reductase metF 0.0069
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0069
5094 5,10-methylenetetrahydrofolate reductase metF 0.0069
5095 Putidaredoxin reductase camA 0.0069
5115 FkbI fkbI 0.0069
5083 Cryptochrome DASH cry 0.0069
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0069
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0069
3133 UDP-galactopyranose mutase glf 0.0069
5099 UDP-galactopyranose mutase glf 0.0069
5109 Outer membrane protein p64k or PM-6 m-6 0.0069
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0069
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0069
5081 L-aspartate oxidase nadB 0.0069
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0069
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0069
1410 Oxidoreductase HSD17B6 0.0069
4725 Oxidoreductase Not Available 0.0069
5124 Oxidoreductase Not Available 0.0069
5111 Phenylacetone monooxygenase pamO 0.0069
4122 Histone deacetylase 2 HDAC2 0.0069
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0068
2216 Fibroblast growth factor receptor 4 FGFR4 0.0068
1374 Natriuretic peptides B NPPB 0.0068
1827 Gap junction alpha-1 protein GJA1 0.0068
1908 Vascular cell adhesion protein 1 VCAM1 0.0068
1063 Signal transducer and activator of transcription 5B STAT5B 0.0067
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0067
2775 Dihydroorotate dehydrogenase pyrD 0.0066
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0065
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0065
6151 Monocarboxylate transporter 10 SLC16A10 0.0064
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0064
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0064
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0064
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0064
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0064
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0064
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0064
811 Translocator protein TSPO 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4076 Diacylglycerol kinase alpha DGKA 0.0063
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0063
375 SEC14-like protein 3 SEC14L3 0.0063
86 SEC14-like protein 4 SEC14L4 0.0063
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0063
708 Alpha-tocopherol transfer protein TTPA 0.0063
1176 Mitogen-activated protein kinase 1 MAPK1 0.0063
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0063
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0063
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0063
6493 Cytochrome c oxidase subunit 6C COX6C 0.0063
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0063
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0063
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0062
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0062
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0062
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0062
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0062
6559 Cytochrome c oxidase subunit 2 ctaC 0.0062
6669 Cytochrome c oxidase subunit 2 ctaC 0.0062
891 Dihydropteroate synthase folP 0.0062
5359 Dihydropteroate synthase folP 0.0062
7175 Dihydropteroate synthase sulI 0.0062
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0062
6558 Cytochrome c oxidase subunit 1 ctaD 0.0062
1256 5-hydroxytryptamine 6 receptor HTR6 0.0062
2112 Toll-like receptor 9 TLR9 0.0062
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0062
537 ATP synthase delta chain, mitochondrial ATP5D 0.0061
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0061
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0061
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.006
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.006
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.006
5072 N,N-dimethylglycine oxidase dmg 0.006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.006
997 Protein kinase C beta type PRKCB 0.006
3594 Deoxyribodipyrimidine photo-lyase phr 0.006
5079 Deoxyribodipyrimidine photo-lyase phrB 0.006
5080 Deoxyribodipyrimidine photo-lyase phr 0.006
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.006
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.006
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.006
2526 NADPH-ferredoxin reductase fprA fprA 0.006
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.006
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.006
2470 Pyruvate oxidase pox5 0.006
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.006
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
4226 Uridine phosphorylase 2 UPP2 0.0059
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0059
1618 High affinity nerve growth factor receptor NTRK1 0.0059
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0058
2540 Choloylglycine hydrolase cbh 0.0057
5201 FMN-binding protein DvMF_2023 0.0057
3293 Flavodoxin Not Available 0.0057
4614 Flavodoxin DVU_2680 0.0057
5172 Flavodoxin isiB 0.0057
5173 Flavodoxin isiB 0.0057
5182 Flavodoxin fldA 0.0057
5178 Protein nrdI nrdI 0.0057
5198 Flavodoxin-1 fldA 0.0057
5170 Epidermin decarboxylase epiD 0.0057
5131 PhzG phzG 0.0057
5179 Probable aromatic acid decarboxylase pad1 0.0057
5175 Hypothetical protein SMU.260 SMU_260 0.0057
5202 Nitroreductase family protein BC_1844 0.0057
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0057
5181 Hypothetical protein yhdA azr 0.0057
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0057
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0057
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0057
5190 Rubredoxin-oxygen oxidoreductase roo 0.0057
5200 NADH dehydrogenase nox 0.0057
5191 Morphinone reductase morB 0.0057
5193 Phenazine biosynthesis protein phzG phzG 0.0057
4405 Nitric oxide reductase fprA 0.0057
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0057
6500 Phospholipase A2 PLA2G1B 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
5189 Trimethylamine dehydrogenase tmd 0.0056
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0056
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0055
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0055
2893 Glycine oxidase thiO 0.0055
6268 Hydroxyacid oxidase 1 HAO1 0.0055
6506 Stathmin-4 STMN4 0.0055
528 5-hydroxytryptamine 1E receptor HTR1E 0.0055
751 Potassium channel subfamily K member 6 KCNK6 0.0055
4225 Uridine phosphorylase 1 UPP1 0.0055
126 D-lactate dehydrogenase dld 0.0054
3545 D-lactate dehydrogenase Not Available 0.0054
4510 D-lactate dehydrogenase ldhA 0.0054
6501 Fatty acid-binding protein, liver FABP1 0.0054
1970 Protein kinase C alpha type PRKCA 0.0054
94 5-hydroxytryptamine 4 receptor HTR4 0.0054
2567 Thymidylate synthase thyX thyX 0.0053
357 Carbonic anhydrase 2 CA2 0.0052
2823 Trypanothione reductase TPR 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
413 Amidophosphoribosyltransferase PPAT 0.0051
2515 Amidophosphoribosyltransferase purF 0.0051
3714 Amidophosphoribosyltransferase purF 0.0051
856 Vitamin D3 receptor VDR 0.0051
2769 P-hydroxybenzoate hydroxylase pobA 0.0051
2809 P-hydroxybenzoate hydroxylase pobA 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.005
172 Potassium channel subfamily K member 1 KCNK1 0.005
511 5-hydroxytryptamine 1F receptor HTR1F 0.005
80 Peroxisome proliferator-activated receptor alpha PPARA 0.005
1630 Integrin beta-2 ITGB2 0.005
5176 YtnJ moxC 0.005
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.005
3680 Dihydroorotate dehydrogenase A pyrDA 0.005
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0049
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0049
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0049
3507 Chorismate synthase aroC 0.0049
5171 Chorismate synthase aroC 0.0049
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0049
319 Opioid receptor, sigma 1 OPRS1 0.0049
173 Toll-like receptor 7 TLR7 0.0049
4496 C-terminal-binding protein 1 CTBP1 0.0048
2380 Monomeric sarcosine oxidase soxA 0.0048
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0048
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
2236 Casein kinase II subunit alpha CSNK2A1 0.0047
408 Riboflavin kinase RFK 0.0047
427 Substance-P receptor TACR1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
6645 D-amino-acid oxidase DAO 0.0046
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0046
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0046
2232 Interleukin-5 IL5 0.0045
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0045
1593 Mucin-2 MUC2 0.0045
295 Carbonic anhydrase 1 CA1 0.0045
6432 Transporter snf 0.0045
362 Melatonin receptor type 1B MTNR1B 0.0045
571 Melatonin receptor type 1A MTNR1A 0.0045
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0045
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0044
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0044
3830 Calreticulin CALR 0.0044
106 Cannabinoid receptor 2 CNR2 0.0044
5180 L(+)-mandelate dehydrogenase mdlB 0.0043
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0043
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0043
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0043
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0043
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
268 Adenosine A2b receptor ADORA2B 0.0043
3937 Fatty-acid amide hydrolase FAAH 0.0042
3639 Thymidine phosphorylase deoA 0.0042
3936 Thymidine phosphorylase TYMP 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0041
6034 Hydroxyindole O-methyltransferase ASMT 0.0041
6035 Nuclear receptor ROR-beta RORB 0.0041
6036 Eosinophil peroxidase EPX 0.0041
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.004
1262 Corticotropin-lipotropin POMC 0.004
760 Fibroblast growth factor 1 FGF1 0.0039
267 Plasminogen activator inhibitor 1 SERPINE1 0.0039
1517 Beta-3 adrenergic receptor ADRB3 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
4284 Pentaerythritol tetranitrate reductase onr 0.0039
4041 Microsomal glutathione S-transferase 2 MGST2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0039
592 Carbonic anhydrase 4 CA4 0.0038
1123 Eosinophil cationic protein RNASE3 0.0038
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
581 Cytochrome P450 2R1 CYP2R1 0.0037
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0037
3957 Adenosine deaminase ADA 0.0037
6221 Steroid hormone receptor ERR1 ESRRA 0.0036
164 Histamine H4 receptor HRH4 0.0035
340 Apoptotic protease-activating factor 1 APAF1 0.0035
765 Indoleamine 2,3-dioxygenase IDO1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
518 Peroxidase/catalase T katG 0.0035
6102 Arylamine N-acetyltransferase 2 NAT2 0.0034
563 Thyroid peroxidase TPO 0.0034
4103 Proteasome subunit beta type 2 PSMB2 0.0034
4102 Proteasome subunit beta type 5 PSMB5 0.0034
4101 Proteasome subunit beta type 1 PSMB1 0.0034
1928 Leukotriene C4 synthase LTC4S 0.0034
4034 Glutaredoxin-1 GLRX 0.0034
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0034
4037 Hypothetical protein GPX1 0.0034
4297 Hypothetical protein SP_1951 0.0034
4521 Hypothetical protein BC_2969 0.0034
4540 Hypothetical protein TM_1070 0.0034
4555 Hypothetical protein MT1739 0.0034
4569 Hypothetical protein mshD 0.0034
4578 Hypothetical protein PA3270 0.0034
4747 Hypothetical protein PA3967 0.0034
5177 Hypothetical protein TM_0096 0.0034
5194 Hypothetical protein PA1204 0.0034
5240 Hypothetical protein Rv2991 0.0034
5370 Hypothetical protein TM_1158 0.0034
5710 Hypothetical protein Tb927.5.1360 0.0034
907 Glutathione peroxidase 2 GPX2 0.0034
4029 Microsomal glutathione S-transferase 3 MGST3 0.0034
4032 Microsomal glutathione S-transferase 1 MGST1 0.0034
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0034
910 Epididymal secretory glutathione peroxidase GPX5 0.0034
4040 Glutathione peroxidase 7 GPX7 0.0034
4036 Glutathione peroxidase 6 GPX6 0.0034
903 Glutathione S-transferase A5 GSTA5 0.0034
906 Glutathione peroxidase 1 GPX1 0.0034
900 Glutathione S-transferase A4 GSTA4 0.0034
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0034
911 Glutathione peroxidase 3 GPX3 0.0034
4035 Glutathione S-transferase Mu 5 GSTM5 0.0034
4033 S-formylglutathione hydrolase ESD 0.0034
4038 Glutathione peroxidase 4 GPX4 0.0034
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0034
4042 Glutathione transferase omega-2 GSTO2 0.0034
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0033
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0033
4428 Redox-sensing transcriptional repressor rex rex 0.0033
4449 ADP-ribosyltransferase Not Available 0.0033
4418 AGR_L_3209p AGR_L_3209 0.0033
4435 L-aspartate dehydrogenase nadX 0.0033
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0033
4423 Levodione reductase lvr 0.0033
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0033
4443 Quinate/shikimate dehydrogenase ydiB 0.0033
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0033
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0033
4447 Hypothetical protein yhfP yhfP 0.0033
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0033
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0033
3381 Alcohol dehydrogenase Not Available 0.0033
4508 Alcohol dehydrogenase adhA 0.0033
4414 Dehydrogenase TT_P0035 0.0033
2350 3-isopropylmalate dehydrogenase leuB 0.0033
3092 3-isopropylmalate dehydrogenase leuB 0.0033
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0033
4507 Alanine dehydrogenase ald 0.0033
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0033
4455 Glycerol dehydrogenase gldA 0.0033
4497 Benzyl alcohol dehydrogenase xylB 0.0033
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0033
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0033
4487 Transcriptional regulator nadR nadR 0.0033
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0033
3729 Citrate synthase gltA 0.0033
4575 Citrate synthase cit 0.0033
4580 Citrate synthase gltA 0.0033
4451 Vip2Ac vip2Ac 0.0033
4472 Glucose 1-dehydrogenase Not Available 0.0033
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0033
4500 L-lactate dehydrogenase 2 ldh2 0.0033
4502 Formate dehydrogenase Not Available 0.0033
4467 Alpha-glucosidase, putative TM_0752 0.0033
5798 Mitogen-activated protein kinase 11 MAPK11 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
825 Arsenical pump-driving ATPase ASNA1 0.0031
3435 Arsenical pump-driving ATPase arsA 0.0031
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0031
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0031
154 AFG3-like protein 2 AFG3L2 0.0031
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0031
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
733 Activin receptor type 1B ACVR1B 0.0031
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0031
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0031
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0031
395 ALK tyrosine kinase receptor Not Available 0.0031
3319 Hydroxyacylglutathione hydrolase HAGH 0.0031
898 Glutathione S-transferase A3 GSTA3 0.0031
897 Glutathione S-transferase kappa 1 GSTK1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
4954 Soluble cytochrome b558 Not Available 0.003
4925 Cytochrome c-type protein SHP shp 0.003
4934 Cytochrome c-551 nirM 0.003
5218 Cytochrome c-551 nirM 0.003
4905 Cytochrome c2 Not Available 0.003
4939 Cytochrome c2 cycA 0.003
4964 Cytochrome c2 cycA 0.003
4979 Cytochrome c2 cycA 0.003
6673 Cytochrome c2 cycA 0.003
4916 Cyanoglobin glbN 0.003
4994 Hemoglobin-like protein HbO glbO 0.003
4915 Cytochrome c-550 psbV 0.003
4959 Cytochrome c-550 psbV 0.003
5216 Cytochrome c-550 psbV 0.003
4936 Cytochrome c2 iso-2 Not Available 0.003
4943 Cytochrome c6 petJ 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
4975 Cytochrome c-556 RPA3973 0.003
4947 Bacterial hemoglobin vhb 0.003
4998 Hemoglobin-like protein yjbI yjbI 0.003
4942 Diheme cytochrome c napB napB 0.003
4981 Iron-starvation protein PigA pigA 0.003
5000 HemO hemO 0.003
4984 Neuroglobin NGB 0.003
4910 Cytoglobin CYGB 0.003
4909 CooA protein cooA 0.003
4907 Cytochrome c-L moxG 0.003
6865 Cytochrome c-L moxG 0.003
4961 Hemophore HasA hasA 0.003
4935 Cytochrome c-554 cycA1 0.003
4971 Nonaheme cytochrome c hmcA 0.003
4976 Apocytochrome f petA 0.003
6407 Apocytochrome f petA 0.003
4960 Putative cytochrome P450-family protein SCO7417 0.003
4972 P450cin cinA 0.003
4904 Cytochrome c family protein GSU1996 0.003
4764 Cytochrome P450 165C4 CYP165C4 0.003
4937 Cytochrome oxidase subunit II rcoxA 0.003
4989 Cytochrome c551 peroxidase ccp 0.003
5222 Cytochrome c551 peroxidase ccpA 0.003
4931 Cytochrome P450 167A1 CYP167A1 0.003
4999 Cytochrome P450 165B3 CYP165B3 0.003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.003
4922 Cytochrome c, putative SO_4144 0.003
4926 Heme-based aerotactic transducer hemAT hemAT 0.003
4903 Methyl-accepting chemotaxis protein Tar4 0.003
4952 Catalase/peroxidase katA 0.003
4993 Hydroxylamine oxidoreductase hao1 0.003
3093 Catalase HPII katE 0.003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.003
909 Maleylacetoacetate isomerase GSTZ1 0.003
6044 Serum paraoxonase/lactonase 3 PON3 0.003
3950 Cell division protein kinase 9 CDK9 0.0029
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
292 Activin receptor type-1 ACVR1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
849 Activated CDC42 kinase 1 TNK2 0.0028
780 Retinoic acid receptor RXR-gamma RXRG 0.0028
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0028
572 Integrin alpha-L ITGAL 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0027
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0027
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0027
297 Adenylate cyclase type 1 ADCY1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0027
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
2165 Glutathione S-transferase Mu 2 GSTM2 0.0027
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0027
4217 Telomerase reverse transcriptase TERT 0.0027
4427 TDP-glucose-4,6-dehydratase desIV 0.0027
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0027
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0027
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4482 UDP-galactose 4-epimerase galE 0.0027
2967 CDP-paratose 2-epimerase rfbE 0.0027
2507 Diphtheria toxin Not Available 0.0027
2538 6-phospho-beta-glucosidase bglT bglT 0.0027
2393 Maltose-6'-phosphate glucosidase glvA 0.0027
4509 Acetoin(diacetyl) reductase budC 0.0027
2207 Rhodopsin RHO 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3081 3-dehydroquinate synthase aroB 0.0027
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0027
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0027
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0027
3615 Dihydrodipicolinate reductase dapB 0.0027
3618 Dihydrodipicolinate reductase dapB 0.0027
4462 Dihydrodipicolinate reductase dapB 0.0027
3191 Histidinol dehydrogenase hisD 0.0027
2591 Urocanate hydratase hutU 0.0027
4450 Iota toxin component Ia Not Available 0.0027
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0027
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0027
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0027
2424 L-lactate dehydrogenase ldh 0.0027
2641 L-lactate dehydrogenase Not Available 0.0027
4437 L-lactate dehydrogenase ldh 0.0027
4442 L-lactate dehydrogenase ldh 0.0027
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0026
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0026
4498 Ornithine cyclodeaminase PP3533 0.0026
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0026
2336 2,3-diketo-L-gulonate reductase dlgD 0.0026
2018 Deoxyhypusine synthase DHPS 0.0026
207 Glutathione synthetase GSS 0.0026
5269 Glutathione synthetase gshB 0.0026
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0026
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0026
3221 Cytochrome c4 cc4 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
88 Retinoic acid receptor RXR-beta RXRB 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0026
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0026
901 Glutathione S-transferase Mu 4 GSTM4 0.0025
4920 Peroxidase/catalase katG 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
4990 PpcA ppcA 0.0025
1992 Vitamin D-binding protein GC 0.0025
4948 Cytochrome c-553 Not Available 0.0025
4923 Cytochrome c3 DvMF_2499 0.0025
4945 Cytochrome c3 Not Available 0.0025
4949 Cytochrome c3 DVU_3171 0.0025
4968 Cytochrome c3 cytc3 0.0025
4997 Cytochrome c3 SO_2727 0.0025
5219 Cytochrome c3 cyd 0.0025
4385 Cytochrome c' Not Available 0.0025
4967 Cytochrome c' cycA 0.0025
5038 Cytochrome c' Not Available 0.0025
5223 Cytochrome c' cycP 0.0025
1864 RET proto-oncogene RET 0.0025
2119 Cytochrome b5 CYB5A 0.0025
4902 Nine-heme cytochrome c Ddes_2038 0.0025
3570 Cytochrome P450 152A1 cypC 0.0025
2021 Thrombomodulin THBD 0.0025
3189 High-molecular-weight cytochrome c hmcA 0.0025
4289 Cytochrome P450 TT_P0059 0.0025
6262 Cytochrome P450 staP 0.0025
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0025
3375 Acidic cytochrome c3 Not Available 0.0025
4813 Heme oxygenase hmuO 0.0025
5769 Heme oxygenase Not Available 0.0025
4992 Cytochrome c peroxidase Not Available 0.0025
4988 Sulfite oxidase, mitochondrial SUOX 0.0025
2915 Sensor protein fixL fixL 0.0025
4944 Sensor protein fixL fixL 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0025
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0025
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0025
2683 Mono-ADP-ribosyltransferase C3 C3 0.0025
4545 Molybdopterin-converting factor subunit 2 moaE 0.0025
4106 Guanylate kinase GUK1 0.0025
4516 Guanylate kinase gmk 0.0025
4522 Arginine N-succinyltransferase subunit alpha astA 0.0025
4527 Putative hydrolase ycdX ycdX 0.0025
4536 Transcriptional regulator, IclR family TM_0065 0.0025
4529 Oxalate decarboxylase oxdC oxdC 0.0025
2501 Protein ygbM ygbM 0.0025
4546 Aminotransferase, putative TM_1131 0.0025
4514 Citrate lyase beta subunit-like protein citE 0.0025
4781 Citrate lyase beta subunit-like protein DR_1240 0.0025
4524 Mannose-6-phosphate isomerase yvyI 0.0025
4547 Iron binding protein FbpA fbpA 0.0025
4538 Hypothetical protein VC1899 VC_1899 0.0025
4548 Gyrase B gyrB 0.0025
658 Para-aminobenzoate synthase component 1 pabB 0.0025
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0025
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0025
4515 Peripheral plasma membrane protein CASK CASK 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
4504 WbpP Not Available 0.0025
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0024
3367 GDP-mannose 6-dehydrogenase algD 0.0024
4318 Siroheme synthase cysG 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4343 Alpha-glucosidase aglA 0.0024
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0024
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0024
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0024
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
3670 Soluble cytochrome b562 precursor cybC 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
4386 Hemoglobin-like protein HbN glbN 0.0023
3291 Cytochrome c-552 cycA 0.0023
4927 Cytochrome c-552 nrfA 0.0023
4938 Cytochrome c-552 cycA 0.0023
4953 Cytochrome c-552 nrfA 0.0023
5217 Cytochrome c-552 cycM 0.0023
3411 Cytochrome P450 121 cyp121 0.0023
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0023
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0023
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0023
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0023
661 ADP/ATP translocase 1 SLC25A4 0.0023
2826 Glucose--fructose oxidoreductase gfo 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
6021 Adenosine kinase ADK 0.0023
3070 Adenosylhomocysteinase AHCY 0.0023
4424 Adenosylhomocysteinase PFE1050w 0.0023
6278 Adenosylhomocysteinase ahcY 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0022
500 Monocarboxylate transporter 4 SLC16A3 0.0022
3237 Beta-lactamase OXA-2 bla 0.0022
3404 Exotoxin A eta 0.0022
56 Delta-aminolevulinic acid dehydratase ALAD 0.0022
2356 Delta-aminolevulinic acid dehydratase hemB 0.0022
3613 Delta-aminolevulinic acid dehydratase hemB 0.0022
3674 Delta-aminolevulinic acid dehydratase hemB 0.0022
4532 Gephyrin GPHN 0.0022
4542 Glutaminase 1 glsA1 0.0022
4544 Glutaminase 1 glsA1 0.0022
2929 (S)-2-haloacid dehalogenase dhlB 0.0022
2995 (S)-2-haloacid dehalogenase Not Available 0.0022
4533 Glyoxalase family protein BC_1747 0.0022
3759 Glutathione S-transferase gst 0.0022
4541 Glutathione S-transferase GST 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
4528 Phenazine biosynthesis protein PhzD phzD1 0.0022
4517 Probable butyrate kinase 2 buk2 0.0022
3261 Signal recognition particle protein ffh 0.0022
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0022
3127 Nitrite reductase nirS 0.0022
3284 Nitrite reductase nirS 0.0022
2230 Catalase CAT 0.0021
3249 Catalase katA 0.0021
3625 Catalase katA 0.0021
4539 Catalase katA 0.0021
4941 Catalase katB 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
4311 tRNA TRDMT1 0.0021
4325 tRNA trmD 0.0021
4328 tRNA trmD 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
4608 Putative cytochrome P450 SCO1207 0.0021
4963 Putative cytochrome P450 SCO2884 0.0021
6254 Putative cytochrome P450 SCO6998 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
564 Cellular retinoic acid-binding protein 1 CRABP1 0.002
4491 DNA ligase, NAD-dependent ligA 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
2762 UDP-glucose 4-epimerase GALE 0.002
3461 UDP-glucose 4-epimerase galE 0.002
6126 Carbonic anhydrase 7 CA7 0.002
3467 Methylglyoxal synthase mgsA 0.002
3583 6-phosphogluconolactonase pgl 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
859 Cellular retinoic acid-binding protein 2 CRABP2 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1058 Cell division protein kinase 5 CDK5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
4878 Glycoprotein hormones alpha chain CGA 0.0019
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0019
1072 Granzyme B GZMB 0.0019
4877 Beta-mannanase man 0.0019
4869 Major capsid protein A430L 0.0019
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0019
4850 Beta-2-glycoprotein 1 APOH 0.0019
4880 Membrane cofactor protein CD46 0.0019
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0019
4856 CD209 antigen CD209 0.0019
4189 Alpha-galactosidase A GLA 0.0019
4889 Ig epsilon chain C region IGHE 0.0019
4852 Reticulon-4 receptor RTN4R 0.0019
4845 ADAM 33 ADAM33 0.0019
757 Fusion glycoprotein F0 F 0.0019
4875 Fusion glycoprotein F0 F 0.0019
4721 Beta-1,4-mannanase manA 0.0019
1354 Beta-glucuronidase GUSB 0.0019
442 Envelope glycoprotein gp41 0.0019
4859 Envelope glycoprotein env 0.0019
3352 Structural polyprotein Not Available 0.0019
3628 Structural polyprotein Not Available 0.0019
4892 Structural polyprotein Not Available 0.0019
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0019
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0019
1360 Sphingomyelin phosphodiesterase SMPD1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
1507 Cytochrome c CYCS 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
2688 Peptide deformylase def 0.0018
2708 Peptide deformylase def 0.0018
3004 Peptide deformylase def 0.0018
4337 Peptide deformylase def 0.0018
4338 Peptide deformylase def 0.0018
5368 Peptide deformylase def 0.0018
5371 Peptide deformylase def 0.0018
6375 Peptide deformylase def 0.0018
6378 Peptide deformylase def 0.0018
6379 Peptide deformylase def 0.0018
6776 Peptide deformylase def 0.0018
6900 Peptide deformylase def 0.0018
4534 Cytohesin-2 CYTH2 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
693 Hemoglobin subunit beta HBB 0.0018
1792 Tissue-type plasminogen activator PLAT 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
2548 Subtilisin Carlsberg apr 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
976 Platelet glycoprotein IX GP9 0.0017
162 Retinoic acid receptor gamma-1 RARG 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
793 T-cell surface antigen CD2 CD2 0.0017
4861 Interleukin-6 receptor alpha chain IL6R 0.0017
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0017
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0017
3837 Cytokine receptor common beta chain CSF2RB 0.0017
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0016
1184 Interferon beta IFNB1 0.0016
1379 Interleukin-12 subunit beta IL12B 0.0016
6858 Inactive carboxylesterase 4 CES1P1 0.0016
4890 Hemagglutinin HA 0.0016
6566 Hemagglutinin Not Available 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
358 Cystathionine beta-synthase CBS 0.0016
3233 Bile acid receptor NR1H4 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0015
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3140 Hemagglutinin-neuraminidase HN 0.0015
3609 Hemagglutinin-neuraminidase HN 0.0015
3444 Cyanovirin-N Not Available 0.0015
1859 Prostatic acid phosphatase ACPP 0.0015
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
3027 Streptavidin Not Available 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
1541 Metalloproteinase mmp20 0.0014
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
4787 Envelope glycoprotein gp160 env 0.0014
4820 Envelope glycoprotein gp160 env 0.0014
5727 Envelope glycoprotein gp160 env 0.0014
4666 Fucose-binding lectin PA-IIL lecB 0.0014
2372 Bifunctional tail protein 9 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1341 Histamine H3 receptor HRH3 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
554 Low-density lipoprotein receptor LDLR 0.0013
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0013
852 Heparin cofactor 2 SERPIND1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
153 Dopamine beta-hydroxylase DBH 0.0013
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
3480 Mannan endo-1,4-beta-mannosidase manA 0.0013
64 Neuraminidase NA 0.0013
641 Neuraminidase NA 0.0013
2676 Neuraminidase NA 0.0013
3026 Neuraminidase NA 0.0013
3519 Neuraminidase NA 0.0013
6007 Neuraminidase NA 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
1439 Lactotransferrin LTF 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
5682 Ribonuclease pancreatic RNASE1 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
595 Fibrinogen alpha chain FGA 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
1243 Cathepsin D CTSD 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
85 Growth hormone receptor GHR 0.0012
958 Insulin-like growth factor 1 receptor IGF1R 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1275 Estrogen sulfotransferase SULT1E1 0.0012
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0012
2430 Chondroitinase B cslB 0.0012
1295 Fatty acid synthase FASN 0.0012
2581 Chondroitinase AC cslA 0.0012
6307 Ig gamma-2 chain C region IGHG2 0.0012
6847 Lactase-phlorizin hydrolase LCT 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1039 Histone deacetylase 9 HDAC9 0.0011
6459 Glycodelin PAEP 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
3814 Complement C1r subcomponent C1R 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
309 Antithrombin-III SERPINC1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.001
4785 Ig gamma-1 chain C region IGHG1 0.001
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6677 Myelin P2 protein PMP2 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
4692 A/G-specific adenine glycosylase mutY 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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