DT-Web

DB06695 - Dabigatran etexilate


Identification
Name Dabigatran etexilate
Accession Number DB06695
Type small molecule
Description Dabigatran etexilate is an oral prodrug that is metabolized by a serum esterase to dabigatran. It is a synthetic, competitive and reversible direct thrombin inhibitor. Inhibition of thrombin disrupts the coagulation cascade and inhibits the formation of clots. Dabigatran etexilate may be used to decrease the risk of venous thromboembolic events in patients who have undergone total hip or knee replacement surgery, or to prevent stroke and systemic embolism in patients with atrial fibrillation, in whom anticoagulation therapy is indicated. In contrast to warfarin, because its anticoagulant effects are predictable, lab monitoring is not necessary. FDA approved on October 19, 2010.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 627.7332
Groups approved
Monoisotopic Weight 627.316917457
Pharmacology
Indication Dabigatran is indicated for the prevention of venous thromboembolic events in patients who have undergone elective hip or knee replacement surgery (based on RE-NOVATE, RE-MODEL, and RE-MOBILIZE trials). In 2010, it was approved in the US and Canada for prevention of stroke and systemic embolism in patients with atrial fibrillation (approval based on the RE-LY trial). Contraindications: severe renal impairment (CrCL < 30 ml/min); haemorrhagic manifestations, bleeding diathesis or spontaneous or pharmacologic impairment of haemostasis; lesions at risk of clinically significant bleeding (e.g. extensive cerebral infarction (haemorrhagic or ischemic) in the last 6 months, active peptic ulcer disease); concomitant treatment with P-glycoprotein inhibitors (e.g. oral ketoconazole, verapamil); and those with known hypersensitivity to dabigatran, dabigatran etexilate or any ingredient used in the formulation or component of the container. As of December 2012, dabigatran is contraindicated in patients with mechanical prosthetic heart valves.
Mechanism of action Dabigatran etexilate is an inactive pro-drug that is converted to dabigatran, the active form, by esterase-catalyzed hydrolysis in the plasma and liver. Dabigatran, the main active principle in plasma, is a rapid-acting competitive and reversible direct inhibitor of thrombin. Thrombin, a serine protease, is responsible for the conversion of fibrinogen to fibrin in the coagulation cascade. Inhibition of thrombin consequently prevents thrombus development. Dabigatran inhibits free thrombin, fibrin-bound thrombin and thrombin-induced platelet aggregation.
Absorption Peak plasma concentrations were achieved in 6 hours in post surgical patients. In healthy patients, maximum concentrations were achieved in 0.5 to 2 hours. The absolute bioavailability of dabigatran in the body after administration of dabigatran etexilate was 6.5%. Food does not affect the bioavailability of dabigatran etexilate, but it delays the time to peak plasma concentrations by 2 hours. Oral bioavailability may increase by up to 75% when pellets are taken out of the hydroxypropylmethylcellulose (HPMC) capsule. Therefore, capsules should not be opened and pellets taken alone. Furthermore, although absorption of dabigatran etexilate is independent of gastrointestinal acidity, coadministration of pantoprazole (proton pump inhibitor) may reduce the bioavailability of dabigatran. Despite this finding, dose adjustment is not required.
Protein binding Relatively low binding (34-35%) to plasma proteins.
Biotransformation CYP450 enzymes are not involved in the metabolism of dabigatran thus is not expected to interact with drugs metabolized by CYP isoenzymes. Dabigatran is typically metabolised by esterases and microsomal carboxylesterases. Pharmacologically active acylglucoronides are formed via conjugation. Four positional isomers, 1-O, 2-O, 3-O, and 4-O, acylglucuronides exist, each accounting for less than 10% of total plasma dabagatran.
Route of elimination Mainly excreted in urine (85%). Fecal excretion accounts for 6% of the orally administered dose. Dabigatran is primarily eliminated unchanged via the kidneys at a rate of 100 ml/min corresponding to the glomerular filtration rate.
Toxicity The most common adverse reactions include dyspepsia or gastritis-like symptoms. The approximate lethal dose (LD50) in rats and mice was observed at single oral doses of > 2000 mg/kg. Oral doses of 600 mg/kg did not induce any toxicologically meaningful changes in dogs and Rhesus monkeys. Dabigatran was well-tolerated in rats and Rhesus monkeys during repeat-dose toxicity studies. No evidence of mutagenic potential.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiodarone Amiodarone may increase the serum concentration of dabigatran etexilate, resulting in increased risk of bleeding. Consider modifying therapy.
Apixaban Concomitant therapy with another anticoagulant may increase bleed risk. Monitor closely for adverse effects.
Carbamazepine P-Glycoprotein inducers such as carbamazepine may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Dexamethasone P-Glycoprotein inducers such as dexamethasone may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Doxorubicin P-Glycoprotein inducers such as doxorubicin may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Dronedarone Dronedarone inhibits P-glycoprotein transporter thus increasing serum concentrations of dabigatran 1.1-1.9-fold.
Ginkgo biloba Additive anticoagulant/antiplatelet effects of gingko may increase bleed risk for patients on dabigatran. Concomitant therapy should be avoided.
Ketoconazole Coadministration with a strong p-glycoprotein inhibitor may increase the level or effect of dabigatran. Monitor closely for adverse effects.
Lomitapide Dabigatran is a p-glycoprotien (P-gp) substrate. Levels of dabigatran may increase if coadministered with lomipatide, which is a P-gp inhibitor. Thus, it is recommended to dose reduce P-gp substrates (such as ambrisentan, aliskiren, colchicine, digoxin, everolimus, fexofenadine, imatinib, lapatinib, maraviroc, nilotinib, posaconazole, ranolazine, saxagliptin, sirolimus, sitagliptin, talinolol, tolvaptan, topotecan) with the concomitant use of lomipatide.
Mifepristone May lead to excessive post-abortion bleeding in patients on anticoagulant therapy. Concomitant therapy is contraindicated.
Nefazodone P-Glycoprotein inducers such as nefazodone may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Pantoprazole Proton pump inhibitors may decrease the bioavailability of dabigatran by 28% and increase inter-patient pharmacokinetic variability, especially in females. However, dose adjustment is not required.
Prazosin P-Glycoprotein inducers such as prazosin may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Quinidine Quinidine may increase the serum concentration of dabigatran etexilate, resulting in increased bleeding. Consider modification of therapy.
Rifampin P-Glycoprotein inducers such as rifampin may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Rivaroxaban Using additional anticoagulants such as dabigatran can increase the anticoagulant effect of rivaroxaban. Avoid concurrent use of rivaroxaban with other anticoagulants whenever possible, other than during transition periods, due to the possible increased for bleeding.
Tipranavir P-Glycoprotein inducers such as tipranavir may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Trazodone P-Glycoprotein inducers such as trazodone may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Verapamil Verapamil may increase serum concentrations of the active metabolite(s) of dabigatran etexilate, resulting in an increased risk of bleeding. It is also a strong p-glycoprotein inhibitor. Therapy modification should be considered.
Vinblastine P-Glycoprotein inducers such as vinblastine may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Food Interactions
  • St. John's Wort

Targets


Prothrombin
Name Prothrombin
Gene Name F2
Pharmacological action yes
Actions inhibitor
References
  • Squizzato A, Dentali F, Steidl L, Ageno W: New direct thrombin inhibitors. Intern Emerg Med. 2009 Dec;4(6):479-84. Epub 2009 Sep 15. - Pubmed
  • Liesenfeld KH, Schafer HG, Troconiz IF, Tillmann C, Eriksson BI, Stangier J: Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis. Br J Clin Pharmacol. 2006 Nov;62(5):527-37. - Pubmed
  • Karthikeyan G, Eikelboom JW, Hirsh J.:Dabigatran: ready for prime time?Pol Arch Med Wewn. 2010 Apr;120(4):137-42. - Pubmed
DTHybrid score 1.6023

Enzymes


Liver carboxylesterase 1
Name Liver carboxylesterase 1
Gene Name CES1
Actions substrate
References
  • Hu ZY, Parker RB, Herring VL, Laizure SC: Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal Bioanal Chem. 2013 Feb;405(5):1695-704. doi: 10.1007/s00216-012-6576-4. Epub 2012 Dec 14. - Pubmed
DTHybrid score 0.5634
Cocaine esterase
Name Cocaine esterase
Gene Name Not Available
Actions substrate
References
  • Hu ZY, Parker RB, Herring VL, Laizure SC: Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal Bioanal Chem. 2013 Feb;405(5):1695-704. doi: 10.1007/s00216-012-6576-4. Epub 2012 Dec 14. - Pubmed
DTHybrid score Not Available
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Ebner T, Wagner K, Wienen W: Dabigatran acylglucuronide, the major human metabolite of dabigatran: in vitro formation, stability, and pharmacological activity. Drug Metab Dispos. 2010 Sep;38(9):1567-75. doi: 10.1124/dmd.110.033696. Epub 2010 Jun 15. - Pubmed
DTHybrid score 0.2743
UDP-glucuronosyltransferase 2B7
Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Actions Not Available
References
  • Ebner T, Wagner K, Wienen W: Dabigatran acylglucuronide, the major human metabolite of dabigatran: in vitro formation, stability, and pharmacological activity. Drug Metab Dispos. 2010 Sep;38(9):1567-75. doi: 10.1124/dmd.110.033696. Epub 2010 Jun 15. - Pubmed
DTHybrid score 0.207
UDP-glucuronosyltransferase 2B15
Name UDP-glucuronosyltransferase 2B15
Gene Name Not Available
Actions substrate
References
  • Ebner T, Wagner K, Wienen W: Dabigatran acylglucuronide, the major human metabolite of dabigatran: in vitro formation, stability, and pharmacological activity. Drug Metab Dispos. 2010 Sep;38(9):1567-75. doi: 10.1124/dmd.110.033696. Epub 2010 Jun 15. - Pubmed
DTHybrid score Not Available
Ribosyldihydronicotinamide dehydrogenase [quinone]
Name Ribosyldihydronicotinamide dehydrogenase [quinone]
Gene Name NQO2
Actions inhibitor
References
  • Michaelis S, Marais A, Schrey AK, Graebner OY, Schaudt C, Sefkow M, Kroll F, Dreger M, Glinski M, Koester H, Metternich R, Fischer JJ: Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2). J Med Chem. 2012 Apr 26;55(8):3934-44. doi: 10.1021/jm3001339. Epub 2012 Apr 17. - Pubmed
DTHybrid score 0.722

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Galanis T, Thomson L, Palladino M, Merli GJ: New oral anticoagulants. J Thromb Thrombolysis. 2011 Apr;31(3):310-20. - Pubmed
  • Scaglione F: New oral anticoagulants: comparative pharmacology with vitamin K antagonists. Clin Pharmacokinet. 2013 Feb;52(2):69-82. doi: 10.1007/s40262-012-0030-9. - Pubmed
DTHybrid score 0.2765

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1569
4757 Cytochrome P450 2C9 CYP2C9 0.117
3176 Trypsin-1 PRSS1 0.1044
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0988
6016 Cytochrome P450 2C19 CYP2C19 0.0768
4118 Cytochrome P450 3A5 CYP3A5 0.0766
4200 Cytochrome P450 1A2 CYP1A2 0.0765
4119 Cytochrome P450 2D6 CYP2D6 0.0743
20 Prostaglandin G/H synthase 1 PTGS1 0.0722
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0716
4924 Cytochrome P450 2C8 CYP2C8 0.0712
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.068
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.068
587 Serum albumin ALB 0.0668
290 Prostaglandin G/H synthase 2 PTGS2 0.058
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0524
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0502
6107 Cytochrome P450 3A7 CYP3A7 0.0488
6024 Cytochrome P450 1A1 CYP1A1 0.0486
239 Coagulation factor X F10 0.0459
6030 Cytochrome P450 2B6 CYP2B6 0.0443
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.044
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.044
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.043
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0394
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0384
1729 Solute carrier family 22 member 6 SLC22A6 0.0372
862 Multidrug resistance-associated protein 1 ABCC1 0.0367
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0365
1074 Urokinase-type plasminogen activator PLAU 0.0362
6606 Platelet-activating factor acetylhydrolase IB subunit gamma PAFAH1B3 0.0348
4175 Platelet-activating factor acetylhydrolase PLA2G7 0.0348
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0339
2164 Multidrug resistance-associated protein 4 ABCC4 0.033
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0326
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0325
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0324
1898 Cytochrome P450 1B1 CYP1B1 0.0322
6142 Solute carrier family 22 member 8 SLC22A8 0.0296
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0289
24 Thymidylate synthase TMP1 0.0288
359 Thymidylate synthase TYMS 0.0288
2626 Thymidylate synthase thyA 0.0288
2729 Thymidylate synthase thyA 0.0288
5352 Thymidylate synthase THYA 0.0288
5718 Cytochrome P450 2A6 CYP2A6 0.0288
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0283
6013 Cytochrome P450 2E1 CYP2E1 0.0276
467 Delta-type opioid receptor OPRD1 0.0251
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0251
696 Kappa-type opioid receptor OPRK1 0.0247
847 Mu-type opioid receptor OPRM1 0.0245
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0236
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0235
1757 Myeloperoxidase MPO 0.0235
369 Coagulation factor VII F7 0.0232
3810 Catechol O-methyltransferase COMT 0.0231
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0219
4228 Keratin, type II cytoskeletal 7 KRT7 0.0213
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0191
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0189
723 Cytosolic phospholipase A2 PLA2G4A 0.0189
244 Angiotensin-converting enzyme ACE 0.0188
871 Glucocorticoid receptor NR3C1 0.018
3119 Fimbrial protein pilE1 0.0168
3866 Serum amyloid A protein SAA1 0.0163
1200 AMBP protein AMBP 0.0163
1932 Apolipoprotein E APOE 0.0163
6143 Solute carrier family 22 member 7 SLC22A7 0.0158
824 Sodium-dependent serotonin transporter SLC6A4 0.0156
3233 Bile acid receptor NR1H4 0.0156
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0155
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0154
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0153
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0153
556 Alpha-1A adrenergic receptor ADRA1A 0.0151
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.015
776 Bile salt export pump ABCB11 0.015
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0148
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0144
3811 Cytochrome P450 19A1 CYP19A1 0.0144
798 Osteocalcin BGLAP 0.0144
817 DNA topoisomerase 2-alpha TOP2A 0.0143
6102 Arylamine N-acetyltransferase 2 NAT2 0.014
6141 Sodium/bile acid cotransporter SLC10A1 0.0139
6145 Solute carrier family 22 member 1 SLC22A1 0.0137
2178 Metabotropic glutamate receptor 5 GRM5 0.0136
3923 Cholinesterase BCHE 0.0135
6106 Cytochrome P450 2C18 CYP2C18 0.0135
1024 Solute carrier family 22 member 11 SLC22A11 0.0134
373 Transthyretin TTR 0.0132
136 Estrogen receptor ESR1 0.013
738 Monocarboxylate transporter 1 SLC16A1 0.013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0123
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0123
6564 Prephenate dehydrogenase tyrA 0.0122
6240 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 0.0122
1353 DNA topoisomerase 1 TOP1 0.0121
3552 DNA topoisomerase 1 topA 0.0121
6138 Multidrug resistance protein 3 ABCB4 0.0121
1141 Sialidase-1 NEU1 0.012
64 Neuraminidase NA 0.012
641 Neuraminidase NA 0.012
2676 Neuraminidase NA 0.012
3026 Neuraminidase NA 0.012
3519 Neuraminidase NA 0.012
6007 Neuraminidase NA 0.012
400 Coagulation factor IX F9 0.0119
5461 Coagulation factor IX F9 0.0119
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0118
3947 Xanthine dehydrogenase/oxidase XDH 0.0116
1192 Sulfotransferase 1A1 SULT1A1 0.0116
2236 Casein kinase II subunit alpha CSNK2A1 0.0115
3611 Cytidine deaminase cdd 0.0115
3707 Cytidine deaminase cdd 0.0115
4211 Cytidine deaminase CDA 0.0115
3830 Calreticulin CALR 0.0111
118 Organic cation/carnitine transporter 2 SLC22A5 0.0108
831 D(2) dopamine receptor DRD2 0.0108
632 Alpha-1B adrenergic receptor ADRA1B 0.0107
2981 Phospholipase A2, membrane associated PLA2G2A 0.0107
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0106
232 Corticosteroid-binding globulin SERPINA6 0.0106
789 Alpha-1D adrenergic receptor ADRA1D 0.0105
6144 Solute carrier family 22 member 2 SLC22A2 0.0104
4132 Chloride channel protein ClC-Ka CLCNKA 0.0104
5482 Sialidase-2 NEU2 0.0102
1245 Vitamin K-dependent protein S PROS1 0.0102
459 Retinoic acid receptor RXR-alpha RXRA 0.0101
3639 Thymidine phosphorylase deoA 0.0101
3936 Thymidine phosphorylase TYMP 0.0101
122 P2Y purinoceptor 12 P2RY12 0.01
2331 HTH-type transcriptional regulator qacR qacR 0.01
6461 HTH-type transcriptional regulator qacR qacR 0.01
422 Vitamin K-dependent protein C PROC 0.01
6137 Multidrug resistance-associated protein 6 ABCC6 0.0097
2021 Thrombomodulin THBD 0.0097
6500 Phospholipase A2 PLA2G1B 0.0095
275 Arachidonate 5-lipoxygenase ALOX5 0.0095
6828 TetR family transcriptional repressor LfrR lfrR 0.0095
465 Calmodulin CALM1 0.0094
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0093
193 Beta-1 adrenergic receptor ADRB1 0.0093
3384 Macrophage migration inhibitory factor MIF 0.009
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0089
604 Vitamin K-dependent protein Z PROZ 0.0089
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0088
6147 Solute carrier family 22 member 3 SLC22A3 0.0087
6034 Hydroxyindole O-methyltransferase ASMT 0.0086
6035 Nuclear receptor ROR-beta RORB 0.0086
6036 Eosinophil peroxidase EPX 0.0086
502 5-hydroxytryptamine 2A receptor HTR2A 0.0085
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0085
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0084
6042 Prostaglandin reductase 2 PTGR2 0.0084
19 Coagulation factor VIII F8 0.0083
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0083
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0083
267 Plasminogen activator inhibitor 1 SERPINE1 0.0083
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0081
492 Histamine H1 receptor HRH1 0.0081
341 5-hydroxytryptamine 3 receptor HTR3A 0.008
26 Vascular endothelial growth factor receptor 3 FLT4 0.0079
504 Mast/stem cell growth factor receptor KIT 0.0078
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0077
6043 Putative G-protein coupled receptor 44 GPR44 0.0076
6103 Arylamine N-acetyltransferase 1 NAT1 0.0076
32 Vascular endothelial growth factor receptor 1 FLT1 0.0076
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0075
3831 Low-density lipoprotein receptor-related protein 1 LRP1 0.0075
765 Indoleamine 2,3-dioxygenase IDO1 0.0074
3809 Estrogen-related receptor gamma ESRRG 0.0074
571 Melatonin receptor type 1A MTNR1A 0.0074
362 Melatonin receptor type 1B MTNR1B 0.0074
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0072
3851 Serine protease hepsin HPN 0.0071
5414 Fiber protein L5 0.0071
5418 Fiber protein L5 0.0071
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
1756 E-selectin SELE 0.0071
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.007
228 Beta platelet-derived growth factor receptor PDGFRB 0.007
766 Beta-2 adrenergic receptor ADRB2 0.007
6136 Multidrug resistance-associated protein 5 ABCC5 0.007
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0069
23 D(1A) dopamine receptor DRD1 0.0069
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0069
489 Monocarboxylate transporter 2 SLC16A7 0.0068
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0068
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0068
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0066
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0066
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0066
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0065
1313 Lactoylglutathione lyase GLO1 0.0065
407 Vascular endothelial growth factor receptor 2 KDR 0.0065
833 Organic cation/carnitine transporter 1 SLC22A4 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0063
1760 Aminopeptidase N ANPEP 0.0063
6843 Aminopeptidase N pepN 0.0063
869 Estrogen receptor beta ESR2 0.0062
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0062
3629 Endo-N-acetylneuraminidase Not Available 0.0062
6085 Fatty acid-binding protein, intestinal FABP2 0.0062
5416 Coat protein VP1 Not Available 0.0061
117 Sterol O-acyltransferase 1 SOAT1 0.0061
1130 Lithostathine 1 alpha REG1A 0.0061
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.006
6020 Aldehyde oxidase AOX1 0.006
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.006
952 Dipeptidyl peptidase 4 DPP4 0.0059
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0059
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0059
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0059
70 Type-1 angiotensin II receptor AGTR1 0.0059
273 Apoptosis regulator Bcl-2 BCL2 0.0058
2324 Botulinum neurotoxin type B botB 0.0057
3547 Enterotoxin type B entB 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
3917 Methylenetetrahydrofolate reductase MTHFR 0.0057
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0056
2058 P-selectin SELP 0.0056
551 Carnitine O-acetyltransferase CRAT 0.0056
6221 Steroid hormone receptor ERR1 ESRRA 0.0056
4120 NADPH--cytochrome P450 reductase POR 0.0055
6168 Solute carrier family 22 member 16 SLC22A16 0.0055
638 D(3) dopamine receptor DRD3 0.0055
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0055
1039 Histone deacetylase 9 HDAC9 0.0055
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0055
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0054
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0053
6182 Cytochrome P450 2J2 CYP2J2 0.0052
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0051
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0051
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0051
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0051
6031 Cytochrome P450 3A43 CYP3A43 0.0051
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0051
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0051
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.005
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.005
320 5-hydroxytryptamine 1A receptor HTR1A 0.005
844 Epidermal growth factor receptor EGFR 0.005
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.005
731 HIV-1 protease HIV-1 protease 0.005
1792 Tissue-type plasminogen activator PLAT 0.0049
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0049
2570 Tetanus toxin tetX 0.0049
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0049
891 Dihydropteroate synthase folP 0.0049
5359 Dihydropteroate synthase folP 0.0049
7175 Dihydropteroate synthase sulI 0.0049
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0049
1630 Integrin beta-2 ITGB2 0.0048
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0048
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0048
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0047
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0047
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0047
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
4165 P2Y purinoceptor 2 P2RY2 0.0047
4217 Telomerase reverse transcriptase TERT 0.0046
318 Alpha-2A adrenergic receptor ADRA2A 0.0045
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0045
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0044
124 Histamine H2 receptor HRH2 0.0044
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0044
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0044
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0044
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0044
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0043
3941 Amine oxidase [flavin-containing] A MAOA 0.0043
260 Cytochrome P450 51 ERG11 0.0043
761 Cytochrome P450 51 ERG11 0.0043
3163 Cytochrome P450 51 cyp51 0.0043
3939 Amine oxidase [flavin-containing] B MAOB 0.0042
6148 Multidrug resistance-associated protein 7 ABCC10 0.0042
2723 Cholera enterotoxin subunit B ctxB 0.0042
614 Progesterone receptor PGR 0.0041
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0041
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
474 Acetylcholinesterase ACHE 0.004
165 FL cytokine receptor FLT3 0.0039
6044 Serum paraoxonase/lactonase 3 PON3 0.0039
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
1547 Coagulation factor XI F11 0.0039
5798 Mitogen-activated protein kinase 11 MAPK11 0.0039
885 5-hydroxytryptamine 1B receptor HTR1B 0.0038
725 5-hydroxytryptamine 1D receptor HTR1D 0.0038
2654 Complement control protein C3L 0.0037
811 Translocator protein TSPO 0.0037
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0037
572 Integrin alpha-L ITGAL 0.0036
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0036
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0036
380 Cytochrome P450 17A1 CYP17A1 0.0036
2320 Thymidine kinase, cytosolic TK1 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
1618 High affinity nerve growth factor receptor NTRK1 0.0035
1959 Platelet factor 4 PF4 0.0035
3865 Serpin B6 SERPINB6 0.0035
1986 Ceruloplasmin CP 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
1275 Estrogen sulfotransferase SULT1E1 0.0035
814 Ryanodine receptor 1 RYR1 0.0035
2391 Ferrochelatase hemH 0.0035
6502 Ferrochelatase DKFZp686P18130 0.0035
1591 Ferrochelatase, mitochondrial FECH 0.0035
936 Ephrin type-A receptor 2 EPHA2 0.0035
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0034
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0034
430 Follicle-stimulating hormone receptor FSHR 0.0034
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0034
1050 Bile salt sulfotransferase SULT2A1 0.0034
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0033
5787 Angiopoietin-1 receptor TEK 0.0033
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
3842 Multiple coagulation factor deficiency protein 2 MCFD2 0.0033
3841 ERGIC-53 protein LMAN1 0.0033
3840 Asialoglycoprotein receptor 2 ASGR2 0.0033
1847 78 kDa glucose-regulated protein HSPA5 0.0033
1635 von Willebrand factor VWF 0.0033
605 Fumarate reductase flavoprotein subunit frdA 0.0033
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0033
3673 Fumarate reductase flavoprotein subunit fccA 0.0033
4912 Fumarate reductase flavoprotein subunit ifcA 0.0033
6549 Fumarate reductase flavoprotein subunit frdA 0.0033
823 Fibroblast growth factor receptor 2 FGFR2 0.0032
5455 Arylsulfatase A ARSA 0.0032
3587 Gastrotropin FABP6 0.0032
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
2499 Tubulin beta-2C chain TUBB2C 0.0031
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0031
3833 Plasma serine protease inhibitor SERPINA5 0.0031
2072 Endothelial protein C receptor PROCR 0.0031
46 Coagulation factor V F5 0.0031
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.003
6493 Cytochrome c oxidase subunit 6C COX6C 0.003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.003
756 Sex hormone-binding globulin SHBG 0.003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.003
6559 Cytochrome c oxidase subunit 2 ctaC 0.003
6669 Cytochrome c oxidase subunit 2 ctaC 0.003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.003
6558 Cytochrome c oxidase subunit 1 ctaD 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
590 5-hydroxytryptamine 2C receptor HTR2C 0.003
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0029
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0029
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0029
683 Potassium transporter GK0582 0.0029
629 Alpha-2B adrenergic receptor ADRA2B 0.0029
1516 Calnexin CANX 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
2540 Choloylglycine hydrolase cbh 0.0028
6220 Aryl hydrocarbon receptor AHR 0.0028
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0028
737 Mineralocorticoid receptor NR3C2 0.0027
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
777 Tumor necrosis factor TNF 0.0027
468 Cytochrome P450 4A11 CYP4A11 0.0027
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
6501 Fatty acid-binding protein, liver FABP1 0.0026
3937 Fatty-acid amide hydrolase FAAH 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
517 Alcohol dehydrogenase 1C ADH1C 0.0026
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
146 Androgen receptor AR 0.0025
5095 Putidaredoxin reductase camA 0.0025
526 Thioredoxin reductase trxB 0.0025
3767 Thioredoxin reductase trxB 0.0025
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0025
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0025
5122 Mersacidin decarboxylase mrsD 0.0025
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0025
5115 FkbI fkbI 0.0025
3133 UDP-galactopyranose mutase glf 0.0025
5099 UDP-galactopyranose mutase glf 0.0025
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0025
5083 Cryptochrome DASH cry 0.0025
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0025
3763 5,10-methylenetetrahydrofolate reductase metF 0.0025
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0025
5094 5,10-methylenetetrahydrofolate reductase metF 0.0025
5078 Amine oxidase, flavin-containing PSPTO1126 0.0025
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0025
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0025
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0025
5081 L-aspartate oxidase nadB 0.0025
5111 Phenylacetone monooxygenase pamO 0.0025
1410 Oxidoreductase HSD17B6 0.0025
4725 Oxidoreductase Not Available 0.0025
5124 Oxidoreductase Not Available 0.0025
5109 Outer membrane protein p64k or PM-6 m-6 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
76 Nitric-oxide synthase, brain NOS1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
3839 Phytanoyl-CoA dioxygenase, peroxisomal PHYH 0.0023
713 Sodium-dependent dopamine transporter SLC6A3 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0023
4486 Phenol 2-hydroxylase component B pheA2 0.0023
4477 Dihydrolipoyl dehydrogenase lpdV 0.0023
5077 Dihydrolipoyl dehydrogenase Not Available 0.0023
5117 Dihydrolipoyl dehydrogenase lpd 0.0023
4439 Ferredoxin reductase bphA4 0.0023
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0021
5073 Ferredoxin--NADP reductase petH 0.0021
5076 Ferredoxin--NADP reductase fpr 0.0021
5119 Ferredoxin--NADP reductase petH 0.0021
5121 Ferredoxin--NADP reductase fpr 0.0021
2526 NADPH-ferredoxin reductase fprA fprA 0.0021
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0021
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0021
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0021
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0021
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0021
3594 Deoxyribodipyrimidine photo-lyase phr 0.0021
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0021
5080 Deoxyribodipyrimidine photo-lyase phr 0.0021
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0021
5072 N,N-dimethylglycine oxidase dmg 0.0021
2470 Pyruvate oxidase pox5 0.0021
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0021
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0021
2268 Cholesterol oxidase choB 0.0021
2822 Cholesterol oxidase choA 0.0021
378 Alpha-2C adrenergic receptor ADRA2C 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
714 Glutathione reductase, mitochondrial GSR 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
3102 Flavohemoprotein hmp 0.002
4969 Flavohemoprotein hmp 0.002
4440 NADH peroxidase npr 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1656 CYP2B protein CYP2B 0.002
4878 Glycoprotein hormones alpha chain CGA 0.002
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.002
1072 Granzyme B GZMB 0.002
4877 Beta-mannanase man 0.002
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.002
4850 Beta-2-glycoprotein 1 APOH 0.002
4856 CD209 antigen CD209 0.002
4889 Ig epsilon chain C region IGHE 0.002
4869 Major capsid protein A430L 0.002
4852 Reticulon-4 receptor RTN4R 0.002
4880 Membrane cofactor protein CD46 0.002
757 Fusion glycoprotein F0 F 0.002
4875 Fusion glycoprotein F0 F 0.002
4721 Beta-1,4-mannanase manA 0.002
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.002
1354 Beta-glucuronidase GUSB 0.002
442 Envelope glycoprotein gp41 0.002
4859 Envelope glycoprotein env 0.002
4189 Alpha-galactosidase A GLA 0.002
4845 ADAM 33 ADAM33 0.002
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.002
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.002
3352 Structural polyprotein Not Available 0.002
3628 Structural polyprotein Not Available 0.002
4892 Structural polyprotein Not Available 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
2893 Glycine oxidase thiO 0.0019
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0019
365 Dihydrofolate reductase DHFR 0.0019
2381 Dihydrofolate reductase DFR1 0.0019
2833 Dihydrofolate reductase Not Available 0.0019
2931 Dihydrofolate reductase folA 0.0019
3544 Dihydrofolate reductase folA 0.0019
3682 Dihydrofolate reductase folA 0.0019
6642 Dihydrofolate reductase folA 0.0019
6756 Dihydrofolate reductase dfrA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0019
2567 Thymidylate synthase thyX thyX 0.0019
327 Glutathione reductase gor 0.0019
5110 Glutathione reductase GR2 0.0019
2823 Trypanothione reductase TPR 0.0018
126 D-lactate dehydrogenase dld 0.0018
3545 D-lactate dehydrogenase Not Available 0.0018
4510 D-lactate dehydrogenase ldhA 0.0018
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0018
2769 P-hydroxybenzoate hydroxylase pobA 0.0018
2809 P-hydroxybenzoate hydroxylase pobA 0.0018
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0017
6858 Inactive carboxylesterase 4 CES1P1 0.0017
793 T-cell surface antigen CD2 CD2 0.0017
4861 Interleukin-6 receptor alpha chain IL6R 0.0017
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0017
3837 Cytokine receptor common beta chain CSF2RB 0.0017
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
2380 Monomeric sarcosine oxidase soxA 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
6645 D-amino-acid oxidase DAO 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
4890 Hemagglutinin HA 0.0016
6566 Hemagglutinin Not Available 0.0016
1379 Interleukin-12 subunit beta IL12B 0.0016
1184 Interferon beta IFNB1 0.0015
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0015
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
2207 Rhodopsin RHO 0.0014
1178 Adenosine A2a receptor ADORA2A 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1629 Transcription factor AP-1 JUN 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
1859 Prostatic acid phosphatase ACPP 0.0014
3140 Hemagglutinin-neuraminidase HN 0.0014
3609 Hemagglutinin-neuraminidase HN 0.0014
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0014
3444 Cyanovirin-N Not Available 0.0014
554 Low-density lipoprotein receptor LDLR 0.0014
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0014
852 Heparin cofactor 2 SERPIND1 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
4787 Envelope glycoprotein gp160 env 0.0013
4820 Envelope glycoprotein gp160 env 0.0013
5727 Envelope glycoprotein gp160 env 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0013
595 Fibrinogen alpha chain FGA 0.0013
4666 Fucose-binding lectin PA-IIL lecB 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
2372 Bifunctional tail protein 9 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
6432 Transporter snf 0.0013
4773 Deoxycytidine kinase DCK 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0012
3480 Mannan endo-1,4-beta-mannosidase manA 0.0012
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0012
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0012
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0012
958 Insulin-like growth factor 1 receptor IGF1R 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
432 D(4) dopamine receptor DRD4 0.0012
1243 Cathepsin D CTSD 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
1439 Lactotransferrin LTF 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
444 Alcohol dehydrogenase 1B ADH1B 0.0011
469 Annexin A1 ANXA1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0011
3814 Complement C1r subcomponent C1R 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
816 Biliverdin reductase A BLVRA 0.0011
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
427 Substance-P receptor TACR1 0.0011
2430 Chondroitinase B cslB 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
6307 Ig gamma-2 chain C region IGHG2 0.001
2581 Chondroitinase AC cslA 0.001
309 Antithrombin-III SERPINC1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.001
106 Cannabinoid receptor 2 CNR2 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.001
6174 50S ribosomal protein L32 rpmF 0.001
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.001
4203 Histamine N-methyltransferase HNMT 0.001
6847 Lactase-phlorizin hydrolase LCT 0.001
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.001
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.001
328 Sorbitol dehydrogenase SORD 0.001
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
666 NADP-dependent malic enzyme ME1 0.001
597 Dihydropteridine reductase QDPR 0.001
363 NADP-dependent malic enzyme, mitochondrial ME3 0.001
396 Alcohol dehydrogenase 4 ADH4 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.001
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.001
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.001
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.001
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.001
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.001
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.001
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.001
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.001
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.001
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.001
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.001
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.001
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.001
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.001
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.001
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.001
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.001
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.001
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.001
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.001
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
11 NAD(P) transhydrogenase, mitochondrial NNT 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
77 L-lactate dehydrogenase B chain LDHB 0.001
12 Alcohol dehydrogenase class 3 ADH5 0.001
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.001
4192 DNA topoisomerase 2-beta TOP2B 0.001
3957 Adenosine deaminase ADA 0.0009
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0009
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
473 L-lactate dehydrogenase A chain LDHA 0.0009
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
13 Aminomethyltransferase, mitochondrial AMT 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
4785 Ig gamma-1 chain C region IGHG1 0.0009
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0009
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0009
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0009
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0008
6026 Alcohol dehydrogenase 6 ADH6 0.0008
654 Flavin reductase BLVRB 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0008
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0008
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0008
627 11-cis retinol dehydrogenase RDH5 0.0008
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0008
626 Cysteine dioxygenase type 1 CDO1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
251 Alcohol dehydrogenase 1A ADH1A 0.0008
810 Heme oxygenase 1 HMOX1 0.0008
3391 Heme oxygenase 1 pbsA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
908 Glutathione S-transferase theta-1 GSTT1 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0007
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
279 Tyrosinase TYR 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
163 D(1B) dopamine receptor DRD5 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
822 Aldose reductase AKR1B1 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0006
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
291 Nitric-oxide synthase, endothelial NOS3 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6218 Pannexin-1 PANX1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
6014 Cytochrome P450 2A13 CYP2A13 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
295 Carbonic anhydrase 1 CA1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
164 Histamine H4 receptor HRH4 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
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