DT-Web

DB04855 - Dronedarone


Identification
Name Dronedarone
Accession Number DB04855
Type small molecule
Description Dronedarone is a sinus rhythm controller for management of paroxysmal or persistent atrial fibrillation. Classified as a Class III antiarrhythmic but displays properties of all four Vaughan-Williams classes, dronedarone blocks a multitude of channels (sodium, potassium, calcium), and demonstrates antiadrenergic properties. Chemically, it is a benzofuran derivative. FDA approved on July 1, 2009.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 556.756
Groups approved
Monoisotopic Weight 556.297093218
Pharmacology
Indication Management of paroxysmal or persistent atrial fibrillation via restoration of normal sinus rhythm.
Mechanism of action The antiarrhythmic effect of dronedarone may be due to at least two major actions. It prolongs the duration of action potential and refractory period in myocardial tissue via inhibition of sodium and potassium channels. Via inhibition of calcium channels and blockage of beta1-adrenergic receptors, a decrease in AV conduction and sinus node function can be observed. Dronedarone can also cause an increase in blood pressure by inhibition of alpha1-adrenergic receptors.
Absorption Because of presystemic first pass metabolism the absolute bioavailability of dronedarone without food is low, about 4%. It increases to approximately 15% when dronedarone is administered with a high fat meal. After oral administration in fed conditions, peak plasma concentrations of dronedarone and the main circulating active metabolite (N-debutyl metabolite) are reached within 3 to 6 hours. After repeated administration of 400 mg twice daily, steady state is reached within 4 to 8 days of treatment. The steady state Cmax and exposure of the main N-debutyl metabolite is similar to that of the parent compound.
Protein binding Dronedarone and its N-debutyl metabolite is >98% protein bound - mainly to albumin.
Biotransformation Majority of dronedarone is eliminated by first-pass metabolism in the liver by CYP3A4 enzymes (>84%). Dronedarone is also metabolized by CYP2D6 to a lesser extent. N-DBD is its active metabolite (1/10 to 1/3 potency of dronedarone) which can penetrate the blood-brain barrier, placenta, and is excreted in breast milk. However, it does not significantly accumulate in plasma or tissue.
Route of elimination 6% of the dose was excreted in the urine, mainly as metabolites (no unchanged compound excreted in urine), and 84% was excreted in feces, mainly as metabolites.
Toxicity Most common adverse reactions (>=2%) are diarrhea, nausea, abdominal pain, vomiting, and asthenia.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Atorvastatin Dronedarone is a CYP2D6 inhibitor thus increasing serum concentrations of atorvastatin. Lower doses of atorvastatin or consider rosuvastatin as cholesterol lowering therapy as there is no significant interaction between rosuvastatin and dronedarone.
Clarithromycin Clarithromycin is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Conivaptan CYP3A4 Inhibitors (Strong) may increase the serum concentration of Dronedarone. Concurrent use of strong CYP3A4 inhibitors with dronedarone is contraindicated according to dronedarone prescribing information.
Crizotinib Concurrent use with drugs that prolong QTc interval is contraindicated.
Cyclosporine Cyclosporine is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Dabigatran etexilate Dronedarone inhibits P-glycoprotein transporter thus increasing serum concentrations of dabigatran 1.1-1.9-fold.
Digoxin Dronedarone inhibits P-glycoprotein transporter thus increasing serum concentrations of digoxin 2.5-fold.
Diltiazem Diltiazem is a moderate CYP3A4 inhibitor and will increase dronedarone levels 1.4-1.7 fold. Decrease doses of non-dihyropyridinic calcium-channel blocker.
Etravirine Dronedarone, when administered concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to avoid this combination.
Fingolimod Pharmacodynamic synergist. Contraindicated. Increased risk of bradycardia, AV block, and torsade de pointes.
Itraconazole Itraconazole is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Ketoconazole Ketoconazole is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Metoprolol Metoprolol is a CYP2D6 substrate and because dronedarone inhibits this enzyme, will increase metoprolol exposure 1.6-fold. Lower dose of metoprolol.
Nefazodone Nefazodone is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Propranolol Propranolol is a CYP2D6 substrate and because dronedarone inhibits this enzyme, will increase propranolol exposure 1.3-fold. Lower dose of metoprolol.
Ritonavir Ritonavir is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Simvastatin Dronedarone is a CYP2D6 inhibitor thus increasing serum concentrations of simvastatin 4-fold. Lower doses of simvastatin and doses should not exceed 20 mg to avoid statin-induced toxicities like myopathy. Consider rosuvastatin as cholesterol lowering therapy as there is no significant interaction between rosuvastatin and dronedarone.
Sirolimus Sirolimus is a CYP3A substrate with a narrow therapeutic index thus concomitant therapy with dronedarone will increase plasma levels of sirolimus. Monitor plasma concentrations and adjust dose accordingly.
Tacrolimus Tacrolimus is a CYP3A substrate with a narrow therapeutic index thus concomitant therapy with dronedarone will increase plasma levels of tacrolimus. Monitor plasma concentrations and adjust dose accordingly.
Telithromycin Telithromycin is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Verapamil Verapamil is a moderate CYP3A4 inhibitor and will increase dronedarone levels 1.4-1.7 fold. Decrease doses of non-dihyropyridinic calcium-channel blocker.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration by decreasing its metabolism. Additive QTc prolongation may also occur. Concomitant therapy is contraindicated.
Voriconazole Voriconazole is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Vorinostat Additive QTc prolongation may occur. Concomitant therapy is contraindicated.
Warfarin Dronedarone is a moderate inhibitor of CYP3A4 which is responsible for warfarin metabolism. Increases serum concentration of S-isomer warfarin by 1.2 fold
Ziprasidone Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Zuclopenthixol Additive or synergistic QTc-prolonging effects may occur. Concomitant therapy is contraindicated.
Food Interactions
  • Absorption of dronedarone increases 3-fold if taken with food especially if meal is high in fat content
  • Do not take dronedarone with grapefruit juice. Grapefruit juice is a potent CYP3A4 inhibitor which will increase serum concentrations of dronedarone threefold

Targets


Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action unknown
Actions antagonist
References
  • Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. - Pubmed
DTHybrid score 0.7703
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action unknown
Actions antagonist
References
  • Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. - Pubmed
DTHybrid score 0.5748
Alpha-1D adrenergic receptor
Name Alpha-1D adrenergic receptor
Gene Name ADRA1D
Pharmacological action unknown
Actions Not Available
References
  • Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. - Pubmed
DTHybrid score 0.442
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action unknown
Actions Not Available
References
  • Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. - Pubmed
DTHybrid score 0.6432
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action unknown
Actions Not Available
References
  • Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. - Pubmed
DTHybrid score 0.4402
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action unknown
Actions Not Available
References
  • Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. - Pubmed
DTHybrid score 0.4233
Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action unknown
Actions Not Available
References
  • Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. - Pubmed
DTHybrid score 0.6568
Potassium voltage-gated channel subfamily H member 2
Name Potassium voltage-gated channel subfamily H member 2
Gene Name KCNH2
Pharmacological action unknown
Actions Not Available
References
  • Iwamoto T, Watanabe Y, Kita S, Blaustein MP: Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. Cardiovasc Hematol Disord Drug Targets. 2007 Sep;7(3):188-98. - Pubmed
DTHybrid score 0.4556
Voltage-dependent L-type calcium channel subunit alpha-1C
Name Voltage-dependent L-type calcium channel subunit alpha-1C
Gene Name CACNA1C
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.7258
Voltage-dependent L-type calcium channel subunit alpha-1D
Name Voltage-dependent L-type calcium channel subunit alpha-1D
Gene Name CACNA1D
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.5984
Voltage-dependent L-type calcium channel subunit alpha-1F
Name Voltage-dependent L-type calcium channel subunit alpha-1F
Gene Name CACNA1F
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.4318
Voltage-dependent L-type calcium channel subunit alpha-1S
Name Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name CACNA1S
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.6458
Voltage-dependent L-type calcium channel subunit beta-1
Name Voltage-dependent L-type calcium channel subunit beta-1
Gene Name CACNB1
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.4663
Voltage-dependent L-type calcium channel subunit beta-2
Name Voltage-dependent L-type calcium channel subunit beta-2
Gene Name CACNB2
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.6014
Voltage-dependent L-type calcium channel subunit beta-3
Name Voltage-dependent L-type calcium channel subunit beta-3
Gene Name CACNB3
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.3797
Voltage-dependent L-type calcium channel subunit beta-4
Name Voltage-dependent L-type calcium channel subunit beta-4
Gene Name CACNB4
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.3808
Sodium channel protein type 1 subunit alpha
Name Sodium channel protein type 1 subunit alpha
Gene Name SCN1A
Pharmacological action unknown
Actions inhibitor
References
  • Lalevee N, Nargeot J, Barrere-Lemaire S, Gautier P, Richard S: Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes. J Cardiovasc Electrophysiol. 2003 Aug;14(8):885-90. - Pubmed
DTHybrid score 0.5929
Potassium channel subfamily K member 2
Name Potassium channel subfamily K member 2
Gene Name KCNK2
Pharmacological action unknown
Actions inhibitor
References
  • Schmidt C, Wiedmann F, Schweizer PA, Becker R, Katus HA, Thomas D: Novel electrophysiological properties of dronedarone: inhibition of human cardiac two-pore-domain potassium (K2P) channels. Naunyn Schmiedebergs Arch Pharmacol. 2012 Oct;385(10):1003-16. doi: 10.1007/s00210-012-0780-9. Epub 2012 Jul 13. - Pubmed
DTHybrid score 0.3821

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • -
  • Dorian P: Clinical pharmacology of dronedarone: implications for the therapy of atrial fibrillation. J Cardiovasc Pharmacol Ther. 2010 Dec;15(4 Suppl):15S-8S. Epub 2010 May 14. - Pubmed
  • Schafer JA, Kjesbo NK, Gleason PP: Dronedarone: current evidence and future questions. Cardiovasc Ther. 2010 Spring;28(1):38-47. - Pubmed
  • De Ferrari GM, Dusi V: Drug safety evaluation of dronedarone in atrial fibrillation. Expert Opin Drug Saf. 2012 Nov;11(6):1023-45. doi: 10.1517/14740338.2012.722994. Epub 2012 Sep 13. - Pubmed
DTHybrid score 0.9372
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Schafer JA, Kjesbo NK, Gleason PP: Dronedarone: current evidence and future questions. Cardiovasc Ther. 2010 Spring;28(1):38-47. - Pubmed
  • De Ferrari GM, Dusi V: Drug safety evaluation of dronedarone in atrial fibrillation. Expert Opin Drug Saf. 2012 Nov;11(6):1023-45. doi: 10.1517/14740338.2012.722994. Epub 2012 Sep 13. - Pubmed
DTHybrid score 0.721

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • De Ferrari GM, Dusi V: Drug safety evaluation of dronedarone in atrial fibrillation. Expert Opin Drug Saf. 2012 Nov;11(6):1023-45. doi: 10.1517/14740338.2012.722994. Epub 2012 Sep 13. - Pubmed
  • Schafer JA, Kjesbo NK, Gleason PP: Dronedarone: current evidence and future questions. Cardiovasc Ther. 2010 Spring;28(1):38-47. - Pubmed
DTHybrid score 0.6242

Carriers


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.6242

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.4132
4118 Cytochrome P450 3A5 CYP3A5 0.3675
766 Beta-2 adrenergic receptor ADRB2 0.3616
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.3198
4757 Cytochrome P450 2C9 CYP2C9 0.3056
6016 Cytochrome P450 2C19 CYP2C19 0.2775
6107 Cytochrome P450 3A7 CYP3A7 0.2552
831 D(2) dopamine receptor DRD2 0.245
502 5-hydroxytryptamine 2A receptor HTR2A 0.2377
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.2304
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.2189
4924 Cytochrome P450 2C8 CYP2C8 0.2181
23 D(1A) dopamine receptor DRD1 0.2173
6030 Cytochrome P450 2B6 CYP2B6 0.2029
320 5-hydroxytryptamine 1A receptor HTR1A 0.2022
492 Histamine H1 receptor HRH1 0.1738
6013 Cytochrome P450 2E1 CYP2E1 0.1661
590 5-hydroxytryptamine 2C receptor HTR2C 0.1658
6024 Cytochrome P450 1A1 CYP1A1 0.1655
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1643
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.1528
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1383
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.138
638 D(3) dopamine receptor DRD3 0.1347
432 D(4) dopamine receptor DRD4 0.1335
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.1307
6145 Solute carrier family 22 member 1 SLC22A1 0.1291
824 Sodium-dependent serotonin transporter SLC6A4 0.1289
885 5-hydroxytryptamine 1B receptor HTR1B 0.1273
725 5-hydroxytryptamine 1D receptor HTR1D 0.1236
163 D(1B) dopamine receptor DRD5 0.1207
6220 Aryl hydrocarbon receptor AHR 0.1186
1517 Beta-3 adrenergic receptor ADRB3 0.1182
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.1169
737 Mineralocorticoid receptor NR3C2 0.1126
5718 Cytochrome P450 2A6 CYP2A6 0.1081
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.1073
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.1071
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0982
713 Sodium-dependent dopamine transporter SLC6A3 0.0924
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0897
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0891
6144 Solute carrier family 22 member 2 SLC22A2 0.088
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0878
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0868
465 Calmodulin CALM1 0.0826
436 5-hydroxytryptamine 2B receptor HTR2B 0.0823
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0816
118 Organic cation/carnitine transporter 2 SLC22A5 0.0815
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.08
716 5-hydroxytryptamine 7 receptor HTR7 0.0767
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0749
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0743
3941 Amine oxidase [flavin-containing] A MAOA 0.0735
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.073
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0725
6147 Solute carrier family 22 member 3 SLC22A3 0.0673
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0661
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0659
131 Synaptic vesicular amine transporter SLC18A2 0.065
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0648
1256 5-hydroxytryptamine 6 receptor HTR6 0.0641
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0623
3923 Cholinesterase BCHE 0.0601
862 Multidrug resistance-associated protein 1 ABCC1 0.0594
6106 Cytochrome P450 2C18 CYP2C18 0.0579
828 Phenylalanine-4-hydroxylase PAH 0.0526
3109 Phenylalanine-4-hydroxylase phhA 0.0526
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0505
20 Prostaglandin G/H synthase 1 PTGS1 0.0501
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.05
833 Organic cation/carnitine transporter 1 SLC22A4 0.0492
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0481
776 Bile salt export pump ABCB11 0.0478
751 Potassium channel subfamily K member 6 KCNK6 0.0473
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0447
341 5-hydroxytryptamine 3 receptor HTR3A 0.0442
1729 Solute carrier family 22 member 6 SLC22A6 0.0437
6048 Troponin C, skeletal muscle TNNC2 0.043
172 Potassium channel subfamily K member 1 KCNK1 0.0428
2164 Multidrug resistance-associated protein 4 ABCC4 0.0407
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0403
6070 Nischarin NISCH 0.0397
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0365
6148 Multidrug resistance-associated protein 7 ABCC10 0.036
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0356
528 5-hydroxytryptamine 1E receptor HTR1E 0.0355
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0351
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.035
3939 Amine oxidase [flavin-containing] B MAOB 0.0345
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0341
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0339
6020 Aldehyde oxidase AOX1 0.0335
290 Prostaglandin G/H synthase 2 PTGS2 0.0303
3811 Cytochrome P450 19A1 CYP19A1 0.0301
871 Glucocorticoid receptor NR3C1 0.0295
124 Histamine H2 receptor HRH2 0.0285
6142 Solute carrier family 22 member 8 SLC22A8 0.0279
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0272
847 Mu-type opioid receptor OPRM1 0.027
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0266
6182 Cytochrome P450 2J2 CYP2J2 0.0265
817 DNA topoisomerase 2-alpha TOP2A 0.0264
6138 Multidrug resistance protein 3 ABCB4 0.0262
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0257
696 Kappa-type opioid receptor OPRK1 0.0245
891 Dihydropteroate synthase folP 0.0245
5359 Dihydropteroate synthase folP 0.0245
7175 Dihydropteroate synthase sulI 0.0245
592 Carbonic anhydrase 4 CA4 0.0244
1636 Trace amine-associated receptor 1 TAAR1 0.0243
1898 Cytochrome P450 1B1 CYP1B1 0.024
467 Delta-type opioid receptor OPRD1 0.0238
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0233
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0229
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0229
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0215
295 Carbonic anhydrase 1 CA1 0.0212
136 Estrogen receptor ESR1 0.0211
1108 Calpastatin CAST 0.0211
1089 Cartilage oligomeric matrix protein COMP 0.0211
3810 Catechol O-methyltransferase COMT 0.0209
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0201
357 Carbonic anhydrase 2 CA2 0.0199
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0196
731 HIV-1 protease HIV-1 protease 0.0196
6143 Solute carrier family 22 member 7 SLC22A7 0.0193
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0183
1024 Solute carrier family 22 member 11 SLC22A11 0.0181
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0181
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0181
6151 Monocarboxylate transporter 10 SLC16A10 0.0175
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0174
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0171
1389 Transforming growth factor beta-1 TGFB1 0.0169
474 Acetylcholinesterase ACHE 0.0157
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0156
183 Vascular endothelial growth factor A VEGFA 0.0149
260 Cytochrome P450 51 ERG11 0.0144
761 Cytochrome P450 51 ERG11 0.0144
3163 Cytochrome P450 51 cyp51 0.0144
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0144
3086 Plasmepsin-2 Not Available 0.0143
4120 NADPH--cytochrome P450 reductase POR 0.0143
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
1656 CYP2B protein CYP2B 0.0138
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0136
844 Epidermal growth factor receptor EGFR 0.0133
3947 Xanthine dehydrogenase/oxidase XDH 0.0132
4604 Liver carboxylesterase 1 CES1 0.0132
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.013
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.013
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.013
614 Progesterone receptor PGR 0.0128
2132 Protein S100-B S100B 0.0126
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0125
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0125
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0124
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
1374 Natriuretic peptides B NPPB 0.0123
1827 Gap junction alpha-1 protein GJA1 0.0123
1908 Vascular cell adhesion protein 1 VCAM1 0.0123
3076 Antigen 85-C fbpC 0.0122
756 Sex hormone-binding globulin SHBG 0.0119
777 Tumor necrosis factor TNF 0.0117
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0117
3426 Glutamine synthetase glnA 0.0108
3987 Glutamine synthetase GLUL 0.0108
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0107
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0106
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0106
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0106
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0106
122 P2Y purinoceptor 12 P2RY12 0.0105
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0105
2211 Fatty acid-binding protein, heart FABP3 0.0105
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0105
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0104
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0103
232 Corticosteroid-binding globulin SERPINA6 0.0103
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0102
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0102
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0102
6141 Sodium/bile acid cotransporter SLC10A1 0.0102
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0102
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0101
146 Androgen receptor AR 0.0101
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.01
373 Transthyretin TTR 0.01
6432 Transporter snf 0.0099
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0098
952 Dipeptidyl peptidase 4 DPP4 0.0097
161 Tubulin beta chain TUBB 0.0097
312 Tubulin beta chain TUB2 0.0097
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0097
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0097
380 Cytochrome P450 17A1 CYP17A1 0.0096
70 Type-1 angiotensin II receptor AGTR1 0.0095
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0095
566 Serotransferrin TF 0.0094
6847 Lactase-phlorizin hydrolase LCT 0.0093
94 5-hydroxytryptamine 4 receptor HTR4 0.0092
244 Angiotensin-converting enzyme ACE 0.0092
705 Glutamate receptor 1 GRIA1 0.0091
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0091
6031 Cytochrome P450 3A43 CYP3A43 0.009
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0088
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0087
504 Mast/stem cell growth factor receptor KIT 0.0087
869 Estrogen receptor beta ESR2 0.0086
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0086
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0086
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0086
1820 Beta-nerve growth factor NGF 0.0085
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
738 Monocarboxylate transporter 1 SLC16A1 0.0084
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0084
6137 Multidrug resistance-associated protein 6 ABCC6 0.0084
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0083
537 ATP synthase delta chain, mitochondrial ATP5D 0.0081
482 Glycine receptor subunit alpha-1 GLRA1 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.008
164 Histamine H4 receptor HRH4 0.0078
468 Cytochrome P450 4A11 CYP4A11 0.0078
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0078
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0077
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0077
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0077
1618 High affinity nerve growth factor receptor NTRK1 0.0077
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0074
6085 Fatty acid-binding protein, intestinal FABP2 0.0074
2300 Lysozyme E 0.0073
3633 Lysozyme R 0.0073
5597 Lysozyme 17 0.0073
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0073
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0072
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0072
1353 DNA topoisomerase 1 TOP1 0.0072
3552 DNA topoisomerase 1 topA 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0071
6133 Sodium channel subunit beta-2 SCN2B 0.0071
6135 Sodium channel subunit beta-4 SCN4B 0.0071
6134 Sodium channel subunit beta-3 SCN3B 0.0071
6132 Sodium channel subunit beta-1 SCN1B 0.0071
6127 Carbonic anhydrase-related protein CA8 0.0071
6128 Carbonic anhydrase-related protein 10 CA10 0.0071
6129 Carbonic anhydrase-related protein 11 CA11 0.0071
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0071
811 Translocator protein TSPO 0.0069
1192 Sulfotransferase 1A1 SULT1A1 0.0068
6136 Multidrug resistance-associated protein 5 ABCC5 0.0068
36 Insulin receptor INSR 0.0066
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0066
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0066
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0066
29 Tubulin beta-1 chain TUBB1 0.0066
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0065
3932 Glutathione S-transferase A2 GSTA2 0.0065
6131 Carbonic anhydrase 14 CA14 0.0065
6126 Carbonic anhydrase 7 CA7 0.0065
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0065
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0065
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6130 Carbonic anhydrase 13 CA13 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0063
4237 50S ribosomal protein L22 rplV 0.0062
2449 Tubulin alpha-3 chain TUBA1A 0.0062
2112 Toll-like receptor 9 TLR9 0.0062
407 Vascular endothelial growth factor receptor 2 KDR 0.0062
768 FK506-binding protein 1A FKBP1A 0.0062
6122 Carbonic anhydrase 3 CA3 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0062
228 Beta platelet-derived growth factor receptor PDGFRB 0.0061
185 Vasopressin V1a receptor AVPR1A 0.006
3382 Glycolipid transfer protein GLTP 0.0058
6043 Putative G-protein coupled receptor 44 GPR44 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0058
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
6102 Arylamine N-acetyltransferase 2 NAT2 0.0057
1050 Bile salt sulfotransferase SULT2A1 0.0057
26 Vascular endothelial growth factor receptor 3 FLT4 0.0057
6506 Stathmin-4 STMN4 0.0055
32 Vascular endothelial growth factor receptor 1 FLT1 0.0054
477 DNA topoisomerase 4 subunit A parC 0.0054
886 DNA topoisomerase 4 subunit A parC 0.0054
6226 DNA topoisomerase 4 subunit A parC 0.0054
404 DNA gyrase subunit A gyrA 0.0053
6224 DNA gyrase subunit A gyrA 0.0053
1176 Mitogen-activated protein kinase 1 MAPK1 0.0053
594 Thyroxine-binding globulin SERPINA7 0.0053
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
2183 Fatty acid-binding protein, adipocyte FABP4 0.0052
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0049
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0049
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0049
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0049
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0049
4205 Carbonic anhydrase 9 CA9 0.0049
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0049
3007 Carbonic anhydrase 12 CA12 0.0049
758 Thyroid hormone receptor alpha THRA 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
365 Dihydrofolate reductase DHFR 0.0048
2381 Dihydrofolate reductase DFR1 0.0048
2833 Dihydrofolate reductase Not Available 0.0048
2931 Dihydrofolate reductase folA 0.0048
3544 Dihydrofolate reductase folA 0.0048
3682 Dihydrofolate reductase folA 0.0048
6642 Dihydrofolate reductase folA 0.0048
6756 Dihydrofolate reductase dfrA 0.0048
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
459 Retinoic acid receptor RXR-alpha RXRA 0.0047
683 Potassium transporter GK0582 0.0047
6859 Protein S100-A4 S100A4 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
68 Cannabinoid receptor 1 CNR1 0.0045
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0045
814 Ryanodine receptor 1 RYR1 0.0045
1629 Transcription factor AP-1 JUN 0.0045
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
346 Thyroid hormone receptor beta-1 THRB 0.0044
1178 Adenosine A2a receptor ADORA2A 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
707 72 kDa type IV collagenase MMP2 0.0044
633 Penicillin-binding proteins 1A/1B pbpA 0.0043
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0043
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0043
5787 Angiopoietin-1 receptor TEK 0.0042
1852 Microtubule-associated protein 2 MAP2 0.0042
1360 Sphingomyelin phosphodiesterase SMPD1 0.0041
6014 Cytochrome P450 2A13 CYP2A13 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
904 Glutathione S-transferase P GSTP1 0.004
856 Vitamin D3 receptor VDR 0.004
5251 Carbonyl reductase [NADPH] 1 CBR1 0.004
558 Solute carrier family 12 member 1 SLC12A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
4203 Histamine N-methyltransferase HNMT 0.004
6149 Solute carrier family 22 member 10 SLC22A10 0.0039
1010 Cytochrome P450 51A1 CYP51A1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
24 Thymidylate synthase TMP1 0.0039
359 Thymidylate synthase TYMS 0.0039
2626 Thymidylate synthase thyA 0.0039
2729 Thymidylate synthase thyA 0.0039
5352 Thymidylate synthase THYA 0.0039
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
6677 Myelin P2 protein PMP2 0.0038
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0038
7 Nitric oxide synthase, inducible NOS2 0.0038
2539 Tubulin alpha-1 chain TUBA4A 0.0037
65 Matrix metalloproteinase-9 Not Available 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
780 Retinoic acid receptor RXR-gamma RXRG 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0035
4210 Toll-like receptor 4 TLR4 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
319 Opioid receptor, sigma 1 OPRS1 0.0035
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0035
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
88 Retinoic acid receptor RXR-beta RXRB 0.0034
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0034
4103 Proteasome subunit beta type 2 PSMB2 0.0034
4102 Proteasome subunit beta type 5 PSMB5 0.0034
4101 Proteasome subunit beta type 1 PSMB1 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0033
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0032
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0032
1867 Major prion protein PRNP 0.0032
284 DNA-directed RNA polymerase beta chain rpoB 0.0032
5773 DNA-directed RNA polymerase beta chain rpoB 0.0032
1291 cAMP response element-binding protein CREB1 0.0032
165 FL cytokine receptor FLT3 0.0032
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0032
3856 Fibroblast growth factor receptor 3 FGFR3 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
595 Fibrinogen alpha chain FGA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
199 Monocarboxylate transporter 8 SLC16A2 0.0031
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
291 Nitric-oxide synthase, endothelial NOS3 0.0031
1992 Vitamin D-binding protein GC 0.0031
6824 Tyrosine-protein kinase Lyn LYN 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
239 Coagulation factor X F10 0.003
1714 Mitogen-activated protein kinase 3 MAPK3 0.0029
174 Sigma 1-type opioid receptor SIGMAR1 0.0029
6103 Arylamine N-acetyltransferase 1 NAT1 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
5934 Cytochrome P450 26A1 CYP26A1 0.0029
4773 Deoxycytidine kinase DCK 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0027
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
4122 Histone deacetylase 2 HDAC2 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
16 Adenosine A1 receptor ADORA1 0.0026
273 Apoptosis regulator Bcl-2 BCL2 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0026
605 Fumarate reductase flavoprotein subunit frdA 0.0026
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0026
3673 Fumarate reductase flavoprotein subunit fccA 0.0026
4912 Fumarate reductase flavoprotein subunit ifcA 0.0026
6549 Fumarate reductase flavoprotein subunit frdA 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
2207 Rhodopsin RHO 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
49 Endothelin B receptor EDNRB 0.0026
427 Substance-P receptor TACR1 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0025
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0025
229 Retinoic acid receptor beta RARB 0.0025
162 Retinoic acid receptor gamma-1 RARG 0.0025
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0025
730 Retinoic acid receptor alpha RARA 0.0024
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0024
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
3616 Fatty acid-binding protein, epidermal FABP5 0.0024
5431 Lipid binding protein Not Available 0.0024
5433 UPF0230 protein TM_1468 TM_1468 0.0024
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6459 Glycodelin PAEP 0.0024
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
275 Arachidonate 5-lipoxygenase ALOX5 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
6501 Fatty acid-binding protein, liver FABP1 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
1262 Corticotropin-lipotropin POMC 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
4217 Telomerase reverse transcriptase TERT 0.0022
581 Cytochrome P450 2R1 CYP2R1 0.0022
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0022
3404 Exotoxin A eta 0.0022
1864 RET proto-oncogene RET 0.0021
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0021
298 Renin REN 0.0021
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0021
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0021
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0021
469 Annexin A1 ANXA1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
4311 tRNA TRDMT1 0.0021
4325 tRNA trmD 0.0021
4328 tRNA trmD 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
283 SEC14-like protein 2 SEC14L2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6755 Poliovirus receptor PVR 0.002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.002
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
54 Prothrombin F2 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
6033 High affinity interleukin-8 receptor A CXCR1 0.0018
518 Peroxidase/catalase T katG 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
3937 Fatty-acid amide hydrolase FAAH 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0018
5923 Microtubule-associated protein tau MAPT 0.0018
5924 Microtubule-associated protein 4 MAP4 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
2981 Phospholipase A2, membrane associated PLA2G2A 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0018
2320 Thymidine kinase, cytosolic TK1 0.0018
823 Fibroblast growth factor receptor 2 FGFR2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0017
1630 Integrin beta-2 ITGB2 0.0017
976 Platelet glycoprotein IX GP9 0.0017
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0017
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0017
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0017
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0017
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
2216 Fibroblast growth factor receptor 4 FGFR4 0.0016
33 Cystine/glutamate transporter SLC7A11 0.0016
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
3233 Bile acid receptor NR1H4 0.0015
4192 DNA topoisomerase 2-beta TOP2B 0.0015
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0015
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0015
3957 Adenosine deaminase ADA 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6218 Pannexin-1 PANX1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
3809 Estrogen-related receptor gamma ESRRG 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
563 Thyroid peroxidase TPO 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
2021 Thrombomodulin THBD 0.0015
1757 Myeloperoxidase MPO 0.0015
3917 Methylenetetrahydrofolate reductase MTHFR 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0014
1541 Metalloproteinase mmp20 0.0014
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0014
6073 Potassium channel subfamily K member 9 KCNK9 0.0014
6072 Potassium channel subfamily K member 3 KCNK3 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
489 Monocarboxylate transporter 2 SLC16A7 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
6044 Serum paraoxonase/lactonase 3 PON3 0.0014
1341 Histamine H3 receptor HRH3 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
6146 High affinity copper uptake protein 1 SLC31A1 0.0013
153 Dopamine beta-hydroxylase DBH 0.0013
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0013
921 Glutamate receptor 2 GRIA2 0.0013
572 Integrin alpha-L ITGAL 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
84 Nuclear receptor 0B1 NR0B1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0012
822 Aldose reductase AKR1B1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
694 Matrix protein 2 M 0.0012
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1275 Estrogen sulfotransferase SULT1E1 0.0012
1295 Fatty acid synthase FASN 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
4226 Uridine phosphorylase 2 UPP2 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
6042 Prostaglandin reductase 2 PTGR2 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4225 Uridine phosphorylase 1 UPP1 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
5818 Folate receptor alpha FOLR1 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1792 Tissue-type plasminogen activator PLAT 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
4116 Dihydropteroate synthetase Not Available 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
413 Amidophosphoribosyltransferase PPAT 0.001
2515 Amidophosphoribosyltransferase purF 0.001
3714 Amidophosphoribosyltransferase purF 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.001
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
293 Gamma-glutamyl hydrolase GGH 0.001
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6228 Nuclear receptor coactivator 1 NCOA1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
1313 Lactoylglutathione lyase GLO1 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
1650 Heme carrier protein 1 SLC46A1 0.0009
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0009
3639 Thymidine phosphorylase deoA 0.0008
3936 Thymidine phosphorylase TYMP 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
2298 Cytochrome P450-cam camC 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
76 Nitric-oxide synthase, brain NOS1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
3221 Cytochrome c4 cc4 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6749 Polyprotein Not Available 0.0005
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5961 Insulin INS 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6524 Protein tonB tonB 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
4943 Cytochrome c6 petJ 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
5000 HemO hemO 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4984 Neuroglobin NGB 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4935 Cytochrome c-554 cycA1 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4961 Hemophore HasA hasA 0.0004
4909 CooA protein cooA 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4972 P450cin cinA 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4952 Catalase/peroxidase katA 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
3093 Catalase HPII katE 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
4920 Peroxidase/catalase katG 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
↑