DT-Web

DB00503 - Ritonavir


Identification
Name Ritonavir
Accession Number DB00503 (APRD00312)
Type small molecule
Description An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 720.944
Groups approved
Monoisotopic Weight 720.312760056
Pharmacology
Indication Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.
Mechanism of action Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Absorption The absolute bioavailability of ritonavir has not been determined.
Protein binding 98-99%
Biotransformation Hepatic. Five metabolites have been identified. The isopropylthiazole oxidation metabolite (M-2) is the major metabolite and has antiviral activity similar to that of ritonavir, however, plasma concentrations are low. The cytochrome P450 enzymes CYP3A and CYP2D6 are primarily involved in the metabolism of ritonavir.
Route of elimination Not Available
Toxicity Human experience of acute overdose with ritonavir is limited. One patient in clinical trials took ritonavir 1500 mg/day for two days. The patient reported paresthesias which resolved after the dose was decreased. A post-marketing case of renal failure with eosinophilia has been reported with ritonavir overdose. The approximate lethal dose was found to be greater than 20 times the related human dose in rats and 10 times the related human dose in mice.
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Abacavir The serum concentration of Abacavir may be decreased by protease inhibitors such as Ritonavir. The antiviral response should be closely monitored.
Abiraterone Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Alfuzosin Ritonavir increases the effect/toxicity of alfuzosin
Alprazolam The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, alprazolam.
Aminophylline Ritonavir decreases the effect of theophylline
Amiodarone Ritonavir increases the effect and toxicity of amiodarone
Amitriptyline Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if ritonavir if initiated, discontinued or dose changed.
Amoxapine Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, amoxapine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amoxapine if ritonavir if initiated, discontinued or dose changed.
Apixaban Avoid combination. Otherwise, ritonavir will likely increase apixaban serum concentration.
Aprepitant This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atazanavir Association with dose adjustment
Atomoxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Atorvastatin Ritonavir may increase the serum concentration of atorvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of atorvastatin if ritonavir is initiated, discontinued or dose changed.
Avanafil Co-administration with the strong CYP3A4 inhibitor ritonavir resulted in an approximate 13-fold increase in AUC0-inf and 2.4-fold increase in Cmax of avanafil.
Bepridil Ritonavir increases the effect and toxicity of bepridil
Bromazepam Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if ritonavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Bupropion Ritonavir increases the effect and toxicity of bupropion
Buspirone Ritonavir increases the effect and toxicity of buspirone
Cabazitaxel Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Canagliflozin Nonselective inducers of UGT enzymes may decrease levels of canagliflozin, thus decreasing efficacy. Consider increase the dose to 300 mg once daily.
Carbamazepine Ritonavir increases the effect of carbamazepine
Chlordiazepoxide The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, chlordiazepoxide.
Ciclesonide Increased effects/toxicity of ciclesonide
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clomipramine Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if ritonavir if initiated, discontinued or dose changed.
Clonazepam The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, clonazepam.
Clorazepate The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, clorazepate.
Clozapine Ritonavir increases the effect and toxicity of clozapine
Cyclosporine The protease inhibitor, ritonavir, may increase the effect of cyclosporine.
Dantrolene Ritonavir may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if ritonavir is initiated, discontinued or dose changed.
Darifenacin This potent CYP3A4 inhibitor slows darifenacin/solifenacin metabolism
Delavirdine Increases the effect of ritonavir
Desipramine Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if ritonavir if initiated, discontinued or dose changed.
Diazepam The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, diazepam.
Digoxin Ritonavir increases levels/effect of digoxin
Dihydroergotamine The protease inhibitor, ritonavir, may increase the effect and toxicity of the ergot derivative, dihydroergotamine.
Diltiazem Ritonavir increases diltiazem levels
Doxepin Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if ritonavir if initiated, discontinued or dose changed.
Dronedarone Ritonavir is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Eletriptan The protease inhibitor, ritonavir, may increase the effect and toxicity of eletriptan.
Eplerenone This protease inhibitor, ritonavir, may increase the effect and toxicity of eplerenone.
Ergotamine The protease inhibitor, ritonavir, may increase the effect and toxicity of the ergot derivative, ergotamine.
Erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Erythromycin Increased toxicity of both agents
Estazolam The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, estazolam.
Ethinyl Estradiol Ritonavir could decrease the contraceptive efficacy
Fentanyl Ritonavir increases the effect and toxicity of fentanyl/alfentanyl
Flecainide Ritonavir increases the toxicity of the anti-arrhythmic
Fluoxetine Increased risk of serotonin syndrome
Flurazepam The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, flurazepam.
Fluticasone furoate Strong CYP3A4 inhibitors may increase levels of fluticasone furoate. Consider alternative therapy.
Fusidic Acid The protease inhibitor, ritonavir, may increase the effect and toxicity of fusidic acid.
Gefitinib This CYP3A4 inhibitor increases levels/toxicity of gefitinib
Imipramine Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if ritonavir if initiated, discontinued or dose changed.
Indacaterol Strong inhibitors of CYP3A4 may increase levels of indacaterol. Monitor closely for adverse events.
Itraconazole Itraconazole may increase the effect and toxicity of ritonavir.
Ketoconazole Ketoconazole may increase the effect and toxicity of ritonavir.
Linagliptin CYP3A4 inhibitors may increase levels of linagliptin. Monitor concomitant therapy closely.
Lovastatin Ritonavir may increase the effect and toxicity of lovastatin. Concomitant therapy is contraindicated.
Mefloquine Mefloquine decreases the effect of ritonavir
Meperidine Ritonavir increases the levels of analgesic
Methadone The protease inhibitor, ritonavir, may decrease the effect of methadone.
Midazolam The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, midazolam.
Nortriptyline Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if ritonavir if initiated, discontinued or dose changed.
Olanzapine Ritonavir decreases the effect of olanzapine
Oxtriphylline Ritonavir decreases the effect of theophylline
Pazopanib Ritonavir is a strong inhibitor of CYP3A4 thus increasing exposure of pazopanib.
Pimozide The protease inhibitor, ritonavir, may increase the effect and toxicity of pimozide.
Piroxicam Ritonavir increases the toxicity of piroxicam
Ponatinib Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Ponatinib Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Prasugrel Ritonavir is a inhibitor of CYP3A4, thus blocking the bioactivation of prasugrel. As a result, a reduction in prasugrel efficiency may be observed in patients.
Propafenone Ritonavir increases the effect and toxicity of propafenone
Propoxyphene Ritonavir increases the levels of analgesic
Quinidine Ritonavir increases the effect and toxicity of quinidine
Quinupristin This combination presents an increased risk of toxicity
Ranolazine Increased levels of ranolazine - risk of toxicity
Rifabutin Rifabutin decreases the effect of ritonavir
Rifampin Rifampin decreases the effect of ritonavir
Rivaroxaban Use of rivaroxaban with agents that are strong inhibitors of both CYP3A4 like ritonavir and P-glycoproteins are contraindicated.
Roflumilast Affects CYP1A2 metabolism; decreases level or effect of roflumilast.
Saxagliptin Ritonavir is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Silodosin Strong CYP3A4 inhibitors may increase levels of silodosin. Concomitant administration is contraindicated.
Tacrolimus The protease inhibitor, Ritonavir, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Ritonavir therapy is initiated, discontinued or altered.
Tadalafil Ritonavir may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Ritonavir may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin Ritonavir, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Ritonavir is initiated, discontinued, or dose changed.
Telaprevir Telaprevir increases levels by affecting CYP3A4 metabolism. Concomitant therapy is contraindicated.
Telithromycin Ritonavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects.
Temsirolimus Ritonavir may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Ritonavir, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Ritonavir is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Theophylline Ritonavir decreases the effect of theophylline
Tiagabine The strong CYP3A4 inhibitor, Ritonavir, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Ritonavir is initiated, discontinued or dose changed.
Tolterodine Ritonavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tolvaptan Ritonavir is a strong inhibitor of CYP3A4 and will increase serum concentrations of tolvaptan.
Topotecan The p-glycoprotein inhibitor, Ritonavir, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tramadol Ritonavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Ritonavir may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The protease inhibitor, Ritonavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Ritonavir is initiated, discontinued or dose changed.
Tretinoin The strong CYP2C8 inhibitor, Ritonavir, may decrease the metabolism and clearance of oral Tretinoin. Consider alternate therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Ritonavir is initiated, discontinued to dose changed.
Triazolam The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, triazolam.
Trimipramine The strong CYP3A4/CYP2D6 inhibitor, Ritonavir, may decrease the metabolism and clearance of Trimipramine, a CYP3A4/CYP2D6 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Ritonavir is initiated, discontinued or dose changed.
Vardenafil Ritonavir, a potent CYP3A4 inhibitor, may decrease the metabolism and clearance of Vardenafil. Concomitant therapy is contraindicated.
Vemurafenib Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Venlafaxine Ritonavir, a CYP2D6 and CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 and CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Ritonavir is initiated, discontinued, or dose changed.
Verapamil Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Ritonavir is initiated, discontinued or dose changed.
Vinblastine Ritonavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Ritonavir is initiated, discontinued or dose changed.
Vincristine Ritonavir, a strong CYP3A4 and p-glycoprotein inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism and/or increasing efflux. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Ritonavir is initiated, discontinued or dose changed.
Vinorelbine Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Ritonavir is initiated, discontinued or dose changed.
Voriconazole Ritonavir may decrease the serum concentration of voriconazole by increasing its metabolism. Concomitant therapy with high dose ritonavir is contraindicated. Caution should be used with lower doses as decreased voriconazole efficacy may occur.
Zolpidem Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if ritonavir is initiated, discontinued or dose changed.
Zonisamide Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if ritonavir is initiated, discontinued or dose changed.
Zopiclone Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if ritonavir is initiated, discontinued or dose changed.
Zuclopenthixol Ritonavir, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if ritonavir is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.
  • Avoid St.John's Wort.

Targets


HIV-1 protease
Name HIV-1 protease
Gene Name HIV-1 protease
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Garriga C, Perez-Elias MJ, Delgado R, Ruiz L, Najera R, Pumarola T, Alonso-Socas Mdel M, Garcia-Bujalance S, Menendez-Arias L: Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments. J Med Virol. 2007 Nov;79(11):1617-28. - Pubmed
  • Das A, Rao DR, Hosur MV: X-ray structure of HIV-1 protease tethered dimer complexed to ritonavir. Protein Pept Lett. 2007;14(6):565-8. - Pubmed
  • Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2007 Sep 11;. - Pubmed
DTHybrid score 0.3753

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7286
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inhibitor,inducer
References
  • Tanabe M, Hashimoto M, Ono H: Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. Eur J Pharmacol. 2008 Jul 28;589(1-3):102-5. Epub 2008 Jun 7. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5075
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor,inducer
References
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6152
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4953
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6453
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.2252
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7848
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8231
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6794
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4222

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor,inducer
References
  • Perloff MD, Von Moltke LL, Marchand JE, Greenblatt DJ: Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line. J Pharm Sci. 2001 Nov;90(11):1829-37. - Pubmed
  • Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. - Pubmed
  • Kumar S, Kwei GY, Poon GK, Iliff SA, Wang Y, Chen Q, Franklin RB, Didolkar V, Wang RW, Yamazaki M, Chiu SH, Lin JH, Pearson PG, Baillie TA: Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein. J Pharmacol Exp Ther. 2003 Mar;304(3):1161-71. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH: In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J Pharmacol Exp Ther. 2001 Mar;296(3):723-35. - Pubmed
  • Huisman MT, Smit JW, Wiltshire HR, Hoetelmans RM, Beijnen JH, Schinkel AH: P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir. Mol Pharmacol. 2001 Apr;59(4):806-13. - Pubmed
  • Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed
  • Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed
DTHybrid score 0.8216
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor,inducer
References
  • Perloff MD, Von Moltke LL, Marchand JE, Greenblatt DJ: Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line. J Pharm Sci. 2001 Nov;90(11):1829-37. - Pubmed
  • Olson DP, Scadden DT, D'Aquila RT, De Pasquale MP: The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1). AIDS. 2002 Sep 6;16(13):1743-7. - Pubmed
DTHybrid score 0.3523
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate,inducer
References
  • Dussault I, Lin M, Hollister K, Wang EH, Synold TW, Forman BM: Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR. J Biol Chem. 2001 Sep 7;276(36):33309-12. Epub 2001 Jul 20. - Pubmed
  • Huisman MT, Smit JW, Crommentuyn KM, Zelcer N, Wiltshire HR, Beijnen JH, Schinkel AH: Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS. 2002 Nov 22;16(17):2295-301. - Pubmed
DTHybrid score 0.3763
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
DTHybrid score 0.3436
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Gupta A, Zhang Y, Unadkat JD, Mao Q: HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2004 Jul;310(1):334-41. Epub 2004 Mar 8. - Pubmed
DTHybrid score 0.419
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. - Pubmed
DTHybrid score 0.3811

Predictions


Id Partner name Gene Name Score
6024 Cytochrome P450 1A1 CYP1A1 0.2469
587 Serum albumin ALB 0.2263
5718 Cytochrome P450 2A6 CYP2A6 0.2003
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1729
20 Prostaglandin G/H synthase 1 PTGS1 0.1588
776 Bile salt export pump ABCB11 0.1442
1729 Solute carrier family 22 member 6 SLC22A6 0.1405
6145 Solute carrier family 22 member 1 SLC22A1 0.1387
1181 Alpha-1-acid glycoprotein 1 ORM1 0.128
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1243
492 Histamine H1 receptor HRH1 0.1171
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1163
6106 Cytochrome P450 2C18 CYP2C18 0.1149
2164 Multidrug resistance-associated protein 4 ABCC4 0.1079
1898 Cytochrome P450 1B1 CYP1B1 0.1076
6142 Solute carrier family 22 member 8 SLC22A8 0.1058
824 Sodium-dependent serotonin transporter SLC6A4 0.103
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0997
6144 Solute carrier family 22 member 2 SLC22A2 0.0971
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.095
3811 Cytochrome P450 19A1 CYP19A1 0.0911
118 Organic cation/carnitine transporter 2 SLC22A5 0.0862
6143 Solute carrier family 22 member 7 SLC22A7 0.0847
290 Prostaglandin G/H synthase 2 PTGS2 0.0836
817 DNA topoisomerase 2-alpha TOP2A 0.0819
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0816
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0809
502 5-hydroxytryptamine 2A receptor HTR2A 0.0782
831 D(2) dopamine receptor DRD2 0.0779
136 Estrogen receptor ESR1 0.0778
6141 Sodium/bile acid cotransporter SLC10A1 0.0769
556 Alpha-1A adrenergic receptor ADRA1A 0.0757
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0743
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0727
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0718
6148 Multidrug resistance-associated protein 7 ABCC10 0.0699
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0667
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0652
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0652
847 Mu-type opioid receptor OPRM1 0.0648
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0633
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0624
871 Glucocorticoid receptor NR3C1 0.0615
320 5-hydroxytryptamine 1A receptor HTR1A 0.0605
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0595
6031 Cytochrome P450 3A43 CYP3A43 0.0587
1024 Solute carrier family 22 member 11 SLC22A11 0.0582
6137 Multidrug resistance-associated protein 6 ABCC6 0.058
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0579
6147 Solute carrier family 22 member 3 SLC22A3 0.0577
468 Cytochrome P450 4A11 CYP4A11 0.0554
318 Alpha-2A adrenergic receptor ADRA2A 0.0553
713 Sodium-dependent dopamine transporter SLC6A3 0.0549
260 Cytochrome P450 51 ERG11 0.0533
761 Cytochrome P450 51 ERG11 0.0533
3163 Cytochrome P450 51 cyp51 0.0533
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0532
3941 Amine oxidase [flavin-containing] A MAOA 0.0531
833 Organic cation/carnitine transporter 1 SLC22A4 0.0529
766 Beta-2 adrenergic receptor ADRB2 0.0519
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0517
70 Type-1 angiotensin II receptor AGTR1 0.0513
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0506
467 Delta-type opioid receptor OPRD1 0.0502
590 5-hydroxytryptamine 2C receptor HTR2C 0.0501
23 D(1A) dopamine receptor DRD1 0.0493
341 5-hydroxytryptamine 3 receptor HTR3A 0.0491
632 Alpha-1B adrenergic receptor ADRA1B 0.0479
696 Kappa-type opioid receptor OPRK1 0.0476
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0468
193 Beta-1 adrenergic receptor ADRB1 0.0455
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0448
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0448
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0447
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0446
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0438
465 Calmodulin CALM1 0.0432
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0425
885 5-hydroxytryptamine 1B receptor HTR1B 0.0423
6136 Multidrug resistance-associated protein 5 ABCC5 0.0421
4604 Liver carboxylesterase 1 CES1 0.0415
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0414
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0412
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0411
477 DNA topoisomerase 4 subunit A parC 0.0407
886 DNA topoisomerase 4 subunit A parC 0.0407
6226 DNA topoisomerase 4 subunit A parC 0.0407
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0406
844 Epidermal growth factor receptor EGFR 0.0403
33 Cystine/glutamate transporter SLC7A11 0.0402
404 DNA gyrase subunit A gyrA 0.0401
6224 DNA gyrase subunit A gyrA 0.0401
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0394
3923 Cholinesterase BCHE 0.0391
638 D(3) dopamine receptor DRD3 0.039
504 Mast/stem cell growth factor receptor KIT 0.0387
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0385
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0382
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.038
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0379
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0371
614 Progesterone receptor PGR 0.037
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0368
6182 Cytochrome P450 2J2 CYP2J2 0.0367
725 5-hydroxytryptamine 1D receptor HTR1D 0.0359
146 Androgen receptor AR 0.0353
29 Tubulin beta-1 chain TUBB1 0.0352
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0348
738 Monocarboxylate transporter 1 SLC16A1 0.0347
3939 Amine oxidase [flavin-containing] B MAOB 0.0342
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0336
869 Estrogen receptor beta ESR2 0.0335
26 Vascular endothelial growth factor receptor 3 FLT4 0.0333
737 Mineralocorticoid receptor NR3C2 0.0333
380 Cytochrome P450 17A1 CYP17A1 0.033
756 Sex hormone-binding globulin SHBG 0.0327
6220 Aryl hydrocarbon receptor AHR 0.0326
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0323
4120 NADPH--cytochrome P450 reductase POR 0.0323
122 P2Y purinoceptor 12 P2RY12 0.0321
789 Alpha-1D adrenergic receptor ADRA1D 0.032
32 Vascular endothelial growth factor receptor 1 FLT1 0.0319
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0318
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0314
904 Glutathione S-transferase P GSTP1 0.0312
161 Tubulin beta chain TUBB 0.031
312 Tubulin beta chain TUB2 0.031
407 Vascular endothelial growth factor receptor 2 KDR 0.031
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0305
228 Beta platelet-derived growth factor receptor PDGFRB 0.0298
3587 Gastrotropin FABP6 0.0298
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0291
198 Sodium channel protein type 10 subunit alpha SCN10A 0.029
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0287
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0283
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0279
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0278
629 Alpha-2B adrenergic receptor ADRA2B 0.0278
1353 DNA topoisomerase 1 TOP1 0.0275
3552 DNA topoisomerase 1 topA 0.0275
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0274
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0274
373 Transthyretin TTR 0.027
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0267
3947 Xanthine dehydrogenase/oxidase XDH 0.026
777 Tumor necrosis factor TNF 0.0259
36 Insulin receptor INSR 0.0258
378 Alpha-2C adrenergic receptor ADRA2C 0.0257
811 Translocator protein TSPO 0.0254
1757 Myeloperoxidase MPO 0.0253
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0248
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0247
432 D(4) dopamine receptor DRD4 0.0242
275 Arachidonate 5-lipoxygenase ALOX5 0.0241
891 Dihydropteroate synthase folP 0.0238
5359 Dihydropteroate synthase folP 0.0238
7175 Dihydropteroate synthase sulI 0.0238
2539 Tubulin alpha-1 chain TUBA4A 0.0237
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0236
273 Apoptosis regulator Bcl-2 BCL2 0.0234
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0233
1010 Cytochrome P450 51A1 CYP51A1 0.023
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0229
952 Dipeptidyl peptidase 4 DPP4 0.0228
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0228
6599 HTH-type transcriptional regulator ttgR ttgR 0.0221
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0219
4148 Serine/threonine-protein kinase mTOR MTOR 0.0218
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0217
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0215
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0214
6167 Organic solute transporter subunit beta OSTB 0.0213
6085 Fatty acid-binding protein, intestinal FABP2 0.0213
6166 Organic solute transporter subunit alpha OSTA 0.0213
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0213
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0213
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0213
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0211
94 5-hydroxytryptamine 4 receptor HTR4 0.0211
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0211
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.021
124 Histamine H2 receptor HRH2 0.0208
232 Corticosteroid-binding globulin SERPINA6 0.0206
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0206
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0206
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0205
16 Adenosine A1 receptor ADORA1 0.0204
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0203
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0203
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0203
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0203
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0203
436 5-hydroxytryptamine 2B receptor HTR2B 0.0202
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0201
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.02
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
818 50S ribosomal protein L10 rplJ 0.0198
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0196
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0196
908 Glutathione S-transferase theta-1 GSTT1 0.0193
6102 Arylamine N-acetyltransferase 2 NAT2 0.0193
716 5-hydroxytryptamine 7 receptor HTR7 0.0191
1852 Microtubule-associated protein 2 MAP2 0.0189
117 Sterol O-acyltransferase 1 SOAT1 0.0189
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0188
758 Thyroid hormone receptor alpha THRA 0.0188
1178 Adenosine A2a receptor ADORA2A 0.0186
4122 Histone deacetylase 2 HDAC2 0.0185
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0185
244 Angiotensin-converting enzyme ACE 0.0184
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0184
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0184
6014 Cytochrome P450 2A13 CYP2A13 0.0183
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0183
469 Annexin A1 ANXA1 0.0182
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0182
705 Glutamate receptor 1 GRIA1 0.018
365 Dihydrofolate reductase DHFR 0.0179
2381 Dihydrofolate reductase DFR1 0.0179
2833 Dihydrofolate reductase Not Available 0.0179
2931 Dihydrofolate reductase folA 0.0179
3544 Dihydrofolate reductase folA 0.0179
3682 Dihydrofolate reductase folA 0.0179
6642 Dihydrofolate reductase folA 0.0179
6756 Dihydrofolate reductase dfrA 0.0179
6020 Aldehyde oxidase AOX1 0.0178
482 Glycine receptor subunit alpha-1 GLRA1 0.0178
5923 Microtubule-associated protein tau MAPT 0.0177
165 FL cytokine receptor FLT3 0.0177
5924 Microtubule-associated protein 4 MAP4 0.0177
1656 CYP2B protein CYP2B 0.0177
24 Thymidylate synthase TMP1 0.0175
359 Thymidylate synthase TYMS 0.0175
2626 Thymidylate synthase thyA 0.0175
2729 Thymidylate synthase thyA 0.0175
5352 Thymidylate synthase THYA 0.0175
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0175
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0173
4237 50S ribosomal protein L22 rplV 0.0172
427 Substance-P receptor TACR1 0.017
3810 Catechol O-methyltransferase COMT 0.017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0169
511 5-hydroxytryptamine 1F receptor HTR1F 0.0168
346 Thyroid hormone receptor beta-1 THRB 0.0167
4773 Deoxycytidine kinase DCK 0.0167
4238 50S ribosomal protein L4 rplD 0.0166
5578 50S ribosomal protein L4 rplD 0.0166
6173 50S ribosomal protein L4 rplD 0.0166
6219 50S ribosomal protein L4 rplD 0.0166
723 Cytosolic phospholipase A2 PLA2G4A 0.0166
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0165
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0164
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0164
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0163
1192 Sulfotransferase 1A1 SULT1A1 0.0163
594 Thyroxine-binding globulin SERPINA7 0.0161
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0159
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0159
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0156
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0156
992 Protein tyrosine kinase 2 beta PTK2B 0.0155
174 Sigma 1-type opioid receptor SIGMAR1 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0153
474 Acetylcholinesterase ACHE 0.0153
6146 High affinity copper uptake protein 1 SLC31A1 0.0152
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
163 D(1B) dopamine receptor DRD5 0.0148
1630 Integrin beta-2 ITGB2 0.0148
1629 Transcription factor AP-1 JUN 0.0148
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0147
4192 DNA topoisomerase 2-beta TOP2B 0.0147
1650 Heme carrier protein 1 SLC46A1 0.0146
5787 Angiopoietin-1 receptor TEK 0.0145
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0144
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0143
6149 Solute carrier family 22 member 10 SLC22A10 0.0143
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0143
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0142
1050 Bile salt sulfotransferase SULT2A1 0.0142
6138 Multidrug resistance protein 3 ABCB4 0.0142
3809 Estrogen-related receptor gamma ESRRG 0.0142
183 Vascular endothelial growth factor A VEGFA 0.0142
921 Glutamate receptor 2 GRIA2 0.014
1256 5-hydroxytryptamine 6 receptor HTR6 0.014
5880 Thrombopoietin receptor MPL 0.0139
131 Synaptic vesicular amine transporter SLC18A2 0.0139
6044 Serum paraoxonase/lactonase 3 PON3 0.0137
284 DNA-directed RNA polymerase beta chain rpoB 0.0136
5773 DNA-directed RNA polymerase beta chain rpoB 0.0136
537 ATP synthase delta chain, mitochondrial ATP5D 0.0136
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0135
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0134
823 Fibroblast growth factor receptor 2 FGFR2 0.0133
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0133
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0133
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0132
461 Glycine receptor subunit alpha-3 GLRA3 0.0132
185 Vasopressin V1a receptor AVPR1A 0.0131
4116 Dihydropteroate synthetase Not Available 0.0131
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.013
84 Nuclear receptor 0B1 NR0B1 0.013
295 Carbonic anhydrase 1 CA1 0.013
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.013
3307 Acriflavine resistance protein B acrB 0.013
2808 Chloramphenicol acetyltransferase 3 cat3 0.013
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.013
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0129
768 FK506-binding protein 1A FKBP1A 0.0128
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0128
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0127
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
1618 High affinity nerve growth factor receptor NTRK1 0.0126
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0126
563 Thyroid peroxidase TPO 0.0125
3856 Fibroblast growth factor receptor 3 FGFR3 0.0124
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0124
1517 Beta-3 adrenergic receptor ADRB3 0.0123
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0123
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0123
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0123
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0122
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
3917 Methylenetetrahydrofolate reductase MTHFR 0.0121
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
6163 Copper-transporting ATPase 2 ATP7B 0.0118
6165 Copper-transporting ATPase 1 ATP7A 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
2449 Tubulin alpha-3 chain TUBA1A 0.0116
592 Carbonic anhydrase 4 CA4 0.0116
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0116
896 Glutathione S-transferase Mu 1 GSTM1 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0115
528 5-hydroxytryptamine 1E receptor HTR1E 0.0114
239 Coagulation factor X F10 0.0114
319 Opioid receptor, sigma 1 OPRS1 0.0114
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0113
3932 Glutathione S-transferase A2 GSTA2 0.0113
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
7 Nitric oxide synthase, inducible NOS2 0.011
976 Platelet glycoprotein IX GP9 0.011
5251 Carbonyl reductase [NADPH] 1 CBR1 0.011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
2443 Azurin azu 0.0108
613 Atrial natriuretic peptide receptor A NPR1 0.0106
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0106
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0105
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0105
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0104
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0104
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0104
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0104
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0103
814 Ryanodine receptor 1 RYR1 0.0102
5626 Nucleoside diphosphate kinase B NME2 0.0102
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0101
572 Integrin alpha-L ITGAL 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
357 Carbonic anhydrase 2 CA2 0.0101
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0099
293 Gamma-glutamyl hydrolase GGH 0.0098
199 Monocarboxylate transporter 8 SLC16A2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
4203 Histamine N-methyltransferase HNMT 0.0096
5300 Antigen peptide transporter 1 TAP1 0.0096
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0096
49 Endothelin B receptor EDNRB 0.0096
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0096
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0096
558 Solute carrier family 12 member 1 SLC12A1 0.0095
751 Potassium channel subfamily K member 6 KCNK6 0.0095
153 Dopamine beta-hydroxylase DBH 0.0095
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
1760 Aminopeptidase N ANPEP 0.0095
6843 Aminopeptidase N pepN 0.0095
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0094
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0094
68 Cannabinoid receptor 1 CNR1 0.0094
6432 Transporter snf 0.0094
88 Retinoic acid receptor RXR-beta RXRB 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
489 Monocarboxylate transporter 2 SLC16A7 0.0092
518 Peroxidase/catalase T katG 0.0091
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0091
578 Endothelin-1 receptor EDNRA 0.009
517 Alcohol dehydrogenase 1C ADH1C 0.0089
6043 Putative G-protein coupled receptor 44 GPR44 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0088
2981 Phospholipase A2, membrane associated PLA2G2A 0.0088
172 Potassium channel subfamily K member 1 KCNK1 0.0087
4311 tRNA TRDMT1 0.0087
4325 tRNA trmD 0.0087
4328 tRNA trmD 0.0087
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0086
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0085
6126 Carbonic anhydrase 7 CA7 0.0084
5294 Nucleoside diphosphate kinase A NME1 0.0083
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0083
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0083
850 Vasopressin V1b receptor AVPR1B 0.0081
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0081
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0081
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
1483 Membrane copper amine oxidase AOC3 0.0081
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.008
6837 Serine/threonine-protein kinase 17B STK17B 0.008
1196 Complement decay-accelerating factor CD55 0.008
1525 Heparin-binding growth factor 2 FGF2 0.008
780 Retinoic acid receptor RXR-gamma RXRG 0.0079
3601 Dihydropteroate synthase 1 folP1 0.0079
3807 Dihydropteroate synthase 1 folP1 0.0079
3808 Dihydropteroate synthase 2 folP2 0.0079
54 Prothrombin F2 0.0079
173 Toll-like receptor 7 TLR7 0.0079
444 Alcohol dehydrogenase 1B ADH1B 0.0079
2599 Tyrosine-protein kinase HCK HCK 0.0078
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0078
936 Ephrin type-A receptor 2 EPHA2 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0077
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0077
6210 Tubulin delta chain TUBD1 0.0077
6211 Tubulin epsilon chain TUBE1 0.0077
6212 Tubulin gamma-1 chain TUBG1 0.0077
6168 Solute carrier family 22 member 16 SLC22A16 0.0077
251 Alcohol dehydrogenase 1A ADH1A 0.0077
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0076
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
1541 Metalloproteinase mmp20 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0073
5934 Cytochrome P450 26A1 CYP26A1 0.0073
6174 50S ribosomal protein L32 rpmF 0.0071
856 Vitamin D3 receptor VDR 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.007
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0069
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0069
1275 Estrogen sulfotransferase SULT1E1 0.0069
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0069
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0069
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0068
6218 Pannexin-1 PANX1 0.0068
634 Squalene monooxygenase SQLE 0.0068
7196 Squalene monooxygenase ERG1 0.0068
162 Retinoic acid receptor gamma-1 RARG 0.0068
3086 Plasmepsin-2 Not Available 0.0068
5818 Folate receptor alpha FOLR1 0.0068
106 Cannabinoid receptor 2 CNR2 0.0068
6151 Monocarboxylate transporter 10 SLC16A10 0.0067
702 UMP-CMP kinase CMPK1 0.0067
3913 Glutamic acid decarboxylase GAD65 0.0066
267 Plasminogen activator inhibitor 1 SERPINE1 0.0066
4103 Proteasome subunit beta type 2 PSMB2 0.0066
4102 Proteasome subunit beta type 5 PSMB5 0.0066
4101 Proteasome subunit beta type 1 PSMB1 0.0066
6766 O-GlcNAcase BT_4395 BT_4395 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
581 Cytochrome P450 2R1 CYP2R1 0.0065
342 P protein [Includes: DNA-directed DNA polymerase P 0.0065
612 P protein [Includes: DNA-directed DNA polymerase P 0.0065
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0064
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0064
2021 Thrombomodulin THBD 0.0064
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0063
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
3270 Elongation factor G fusA 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
1291 cAMP response element-binding protein CREB1 0.0061
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.006
6221 Steroid hormone receptor ERR1 ESRRA 0.006
1864 RET proto-oncogene RET 0.006
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0059
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0059
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0059
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0059
6033 High affinity interleukin-8 receptor A CXCR1 0.0059
2232 Interleukin-5 IL5 0.0059
3937 Fatty-acid amide hydrolase FAAH 0.0059
1593 Mucin-2 MUC2 0.0059
4210 Toll-like receptor 4 TLR4 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0058
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
6824 Tyrosine-protein kinase Lyn LYN 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0057
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0057
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0057
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0057
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
291 Nitric-oxide synthase, endothelial NOS3 0.0056
3904 Alanine aminotransferase 2 GPT2 0.0056
2391 Ferrochelatase hemH 0.0056
6502 Ferrochelatase DKFZp686P18130 0.0056
1591 Ferrochelatase, mitochondrial FECH 0.0056
735 Alanine aminotransferase 1 GPT 0.0056
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
3957 Adenosine deaminase ADA 0.0055
6228 Nuclear receptor coactivator 1 NCOA1 0.0054
65 Matrix metalloproteinase-9 Not Available 0.0054
6241 Nuclear receptor coactivator 2 NCOA2 0.0054
714 Glutathione reductase, mitochondrial GSR 0.0053
760 Fibroblast growth factor 1 FGF1 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
1313 Lactoylglutathione lyase GLO1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6042 Prostaglandin reductase 2 PTGR2 0.0053
2216 Fibroblast growth factor receptor 4 FGFR4 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
1992 Vitamin D-binding protein GC 0.0052
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0052
712 Tubulin alpha chain TUB1 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0052
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0051
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0051
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
4217 Telomerase reverse transcriptase TERT 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
5798 Mitogen-activated protein kinase 11 MAPK11 0.0051
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.005
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.005
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.005
6048 Troponin C, skeletal muscle TNNC2 0.005
719 Retinoic acid receptor responder protein 1 RARRES1 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
770 Retinoic acid-induced protein 3 GPRC5A 0.0049
3404 Exotoxin A eta 0.0049
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0049
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0049
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0049
2230 Catalase CAT 0.0048
3249 Catalase katA 0.0048
3625 Catalase katA 0.0048
4539 Catalase katA 0.0048
4941 Catalase katB 0.0048
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0048
6493 Cytochrome c oxidase subunit 6C COX6C 0.0048
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0048
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0048
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0048
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0048
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0048
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0048
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0048
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0048
6559 Cytochrome c oxidase subunit 2 ctaC 0.0048
6669 Cytochrome c oxidase subunit 2 ctaC 0.0048
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0048
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0048
6558 Cytochrome c oxidase subunit 1 ctaD 0.0048
484 Tyrosine-protein kinase ABL2 ABL2 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
164 Histamine H4 receptor HRH4 0.0046
1253 Interferon gamma IFNG 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0046
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0046
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0046
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0046
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0046
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0046
527 Prostacyclin receptor PTGIR 0.0045
718 Folate receptor gamma FOLR3 0.0045
804 Mitochondrial folate transporter/carrier SLC25A32 0.0045
299 Folate receptor beta FOLR2 0.0045
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0045
1063 Signal transducer and activator of transcription 5B STAT5B 0.0045
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
820 Glycine receptor subunit alpha-2 GLRA2 0.0045
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0045
1714 Mitogen-activated protein kinase 3 MAPK3 0.0044
2540 Choloylglycine hydrolase cbh 0.0044
1792 Tissue-type plasminogen activator PLAT 0.0044
1374 Natriuretic peptides B NPPB 0.0044
1827 Gap junction alpha-1 protein GJA1 0.0044
1908 Vascular cell adhesion protein 1 VCAM1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
569 Retinal dehydrogenase 2 ALDH1A2 0.0043
3639 Thymidine phosphorylase deoA 0.0043
3936 Thymidine phosphorylase TYMP 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
6501 Fatty acid-binding protein, liver FABP1 0.0041
1569 G1/S-specific cyclin-D1 CCND1 0.0041
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
2320 Thymidine kinase, cytosolic TK1 0.004
730 Retinoic acid receptor alpha RARA 0.004
4226 Uridine phosphorylase 2 UPP2 0.004
611 Retinal dehydrogenase 1 ALDH1A1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.004
268 Adenosine A2b receptor ADORA2B 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
1039 Histone deacetylase 9 HDAC9 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
85 Growth hormone receptor GHR 0.0038
76 Nitric-oxide synthase, brain NOS1 0.0038
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
4225 Uridine phosphorylase 1 UPP1 0.0037
1360 Sphingomyelin phosphodiesterase SMPD1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6500 Phospholipase A2 PLA2G1B 0.0034
413 Amidophosphoribosyltransferase PPAT 0.0034
2515 Amidophosphoribosyltransferase purF 0.0034
3714 Amidophosphoribosyltransferase purF 0.0034
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0034
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0034
2207 Rhodopsin RHO 0.0033
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0032
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.003
1268 Neuropeptide S receptor NPSR1 0.003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.003
2298 Cytochrome P450-cam camC 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
6459 Glycodelin PAEP 0.0028
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
6073 Potassium channel subfamily K member 9 KCNK9 0.0027
6072 Potassium channel subfamily K member 3 KCNK3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
358 Cystathionine beta-synthase CBS 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
6859 Protein S100-A4 S100A4 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3830 Calreticulin CALR 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
4041 Microsomal glutathione S-transferase 2 MGST2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
1341 Histamine H3 receptor HRH3 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
3221 Cytochrome c4 cc4 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
1058 Cell division protein kinase 5 CDK5 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
4031 Glutathione S-transferase A1 GSTA1 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0017
1928 Leukotriene C4 synthase LTC4S 0.0017
4034 Glutaredoxin-1 GLRX 0.0017
910 Epididymal secretory glutathione peroxidase GPX5 0.0017
4037 Hypothetical protein GPX1 0.0017
4297 Hypothetical protein SP_1951 0.0017
4521 Hypothetical protein BC_2969 0.0017
4540 Hypothetical protein TM_1070 0.0017
4555 Hypothetical protein MT1739 0.0017
4569 Hypothetical protein mshD 0.0017
4578 Hypothetical protein PA3270 0.0017
4747 Hypothetical protein PA3967 0.0017
5177 Hypothetical protein TM_0096 0.0017
5194 Hypothetical protein PA1204 0.0017
5240 Hypothetical protein Rv2991 0.0017
5370 Hypothetical protein TM_1158 0.0017
5710 Hypothetical protein Tb927.5.1360 0.0017
4029 Microsomal glutathione S-transferase 3 MGST3 0.0017
4036 Glutathione peroxidase 6 GPX6 0.0017
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0017
4032 Microsomal glutathione S-transferase 1 MGST1 0.0017
903 Glutathione S-transferase A5 GSTA5 0.0017
4040 Glutathione peroxidase 7 GPX7 0.0017
907 Glutathione peroxidase 2 GPX2 0.0017
900 Glutathione S-transferase A4 GSTA4 0.0017
911 Glutathione peroxidase 3 GPX3 0.0017
906 Glutathione peroxidase 1 GPX1 0.0017
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0017
4035 Glutathione S-transferase Mu 5 GSTM5 0.0017
4042 Glutathione transferase omega-2 GSTO2 0.0017
4038 Glutathione peroxidase 4 GPX4 0.0017
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0017
4033 S-formylglutathione hydrolase ESD 0.0017
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
3319 Hydroxyacylglutathione hydrolase HAGH 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
898 Glutathione S-transferase A3 GSTA3 0.0016
897 Glutathione S-transferase kappa 1 GSTK1 0.0015
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
909 Maleylacetoacetate isomerase GSTZ1 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
899 Glutathione S-transferase Mu 3 GSTM3 0.0015
905 Glutathione transferase omega-1 GSTO1 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
798 Osteocalcin BGLAP 0.0014
2165 Glutathione S-transferase Mu 2 GSTM2 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
207 Glutathione synthetase GSS 0.0013
5269 Glutathione synthetase gshB 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
901 Glutathione S-transferase Mu 4 GSTM4 0.0013
369 Coagulation factor VII F7 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
292 Activin receptor type-1 ACVR1 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
997 Protein kinase C beta type PRKCB 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
822 Aldose reductase AKR1B1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
693 Hemoglobin subunit beta HBB 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
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