DT-Web

DB06589 - Pazopanib


Identification
Name Pazopanib
Accession Number DB06589
Type small molecule
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 437.518
Groups approved
Monoisotopic Weight 437.163393705
Pharmacology
Indication Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Mechanism of action Pazopanib is a second-generation multitargeted tyrosine kinase inhibitor against vascular endothelial growth factor receptor-1, -2, and -3, platelet-derived growth factor receptor-alpha, platelet-derived growth factor receptor-beta, and c-kit. These receptor targets are part of the angiogenesis pathway that facilitates the formation of tumour blood vessel for tumour survival and growth.
Absorption Absorption of pazopanib in cancer patients is slow and incomplete. In patients with solid tumour, over a dose range of 50-2000 mg, absorption is nonlinear. Significant accumulation of pazopanib can also be observed in patients receiving 800 mg once daily for 22 days. Crushing tablets may increase exposure (increase in Cmax and AUC, while Tmax decreases by 2 hours). Bioavailability, oral tablet 800 mg, cancer patient = 21%; Bioavailability may be low due to incomplete absorption from the gastrointestinal tract. The major circulating component of the drug in the systemic is pazopanib, and not its metabolites. Mean maximum plasma concentration= 58.1 ug/mL; Mean AUC= 1037 ug ? h/mL;
Protein binding >99% protein bound, independent of concentrations over a range of 10-100 ?g/mL.
Biotransformation Metabolized by CYP3A4 and to a lesser extent by CYP1A2 and CYP2C8. Metabolites are less active than pazopanib (10 to 20-fold less active). Three of its metabolites can be observed in the systemic and account for <10% of plasma radioactivity.
Route of elimination Primarily excreted via feces (82.2%) and to a negligible extent via urine (<4%) in cancer patients. Most of the administered dose is excreted unchanged. Approximately 10% of dose are oxidative metabolites and are mostly eliminated via the feces.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Carbamazepine Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Cimetidine Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Clarithromycin Clarithromycin is a strong inhibitor of CYP3A4 thus increasing exposure of pazopanib.
Conivaptan CYP3A4 Inhibitors (Strong) may increase the serum concentration of Pazopanib. Avoid concurrent use of pazopanib with strong inhibitors of CYP3A4 whenever possible. If it is not possible to avoid such a combination, reduce pazopanib dose to 400 mg. Further dose reductions may also be required.
Erythromycin Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Etravirine Pazopanib, when used concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to avoid concurrent therapy.
Ifosfamide Ifosfamide decreases plasma levels of pazopanib.
Irinotecan Irinotecan is an uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) substrate and serum concentrations may increase if administered concurrently with pazopanib, an UGT1A1 inhibitor.
Itraconazole Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Ivacaftor Inhibits p-glycoprotein and affects heptatic metabolism via CYP3A4 therefore increases levels of pazopanib. Consider alternate therapy.
Ketoconazole Ketoconazole is a strong inhibitor of CYP3A4 thus increasing exposure of pazopanib by 120% in healthy subjects.
Lapatinib Lapatinib is a weak inhibitor of CYP3A4, BCRP, and p-glycoprotein and may increase exposure of pazopanib. AUC and Cmax increase by 50-60%.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Nefazodone Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Ondansetron Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Paclitaxel Pazopanib increases exposure of paclitaxel
Rifabutin Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Rifampin Concomitant therapy with a CYP3A4 inducer may decrease exposure of pazopanib.
Ritonavir Ritonavir is a strong inhibitor of CYP3A4 thus increasing exposure of pazopanib.
Saquinavir Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Simvastatin Elevated liver enzyme levels may be observed with concomitant therapy with pazopanib. Monitor closely for adverse effects.
Toremifene Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Avoid drinking grapefruit juice as it is a CYP 3A4 inhibitor and will increase exposure of pazopanib
  • Bioavailability increases with food. Take pazopanib on empty stomach.

Targets


Vascular endothelial growth factor receptor 1
Name Vascular endothelial growth factor receptor 1
Gene Name FLT1
Pharmacological action yes
Actions inhibitor
References
  • Sonpavde G, Hutson TE: Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep. 2007 Mar;9(2):115-9. - Pubmed
DTHybrid score 0.7323
Vascular endothelial growth factor receptor 2
Name Vascular endothelial growth factor receptor 2
Gene Name KDR
Pharmacological action yes
Actions inhibitor
References
  • Sonpavde G, Hutson TE: Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep. 2007 Mar;9(2):115-9. - Pubmed
DTHybrid score 1.6117
Vascular endothelial growth factor receptor 3
Name Vascular endothelial growth factor receptor 3
Gene Name FLT4
Pharmacological action yes
Actions Not Available
References
  • Sonpavde G, Hutson TE: Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep. 2007 Mar;9(2):115-9. - Pubmed
DTHybrid score 0.4486
Alpha platelet-derived growth factor receptor
Name Alpha platelet-derived growth factor receptor
Gene Name PDGFRA
Pharmacological action yes
Actions inhibitor
References
  • Sonpavde G, Hutson TE: Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep. 2007 Mar;9(2):115-9. - Pubmed
DTHybrid score 0.5506
Beta platelet-derived growth factor receptor
Name Beta platelet-derived growth factor receptor
Gene Name PDGFRB
Pharmacological action yes
Actions inhibitor
References
  • Sonpavde G, Hutson TE: Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep. 2007 Mar;9(2):115-9. - Pubmed
DTHybrid score 0.5296
Mast/stem cell growth factor receptor
Name Mast/stem cell growth factor receptor
Gene Name KIT
Pharmacological action yes
Actions inhibitor
References
  • Sonpavde G, Hutson TE: Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep. 2007 Mar;9(2):115-9. - Pubmed
DTHybrid score 0.4821
Fibroblast growth factor receptor 3
Name Fibroblast growth factor receptor 3
Gene Name FGFR3
Pharmacological action unknown
Actions inhibitor
References
  • Deeks ED: Pazopanib: in advanced soft tissue sarcoma. Drugs. 2012 Nov 12;72(16):2129-40. doi: 10.2165/11209950-000000000-00000. - Pubmed
DTHybrid score 0.3756
Tyrosine-protein kinase ITK/TSK
Name Tyrosine-protein kinase ITK/TSK
Gene Name ITK
Pharmacological action unknown
Actions inhibitor
References
  • Deeks ED: Pazopanib: in advanced soft tissue sarcoma. Drugs. 2012 Nov 12;72(16):2129-40. doi: 10.2165/11209950-000000000-00000. - Pubmed
DTHybrid score 0.2887
Fibroblast growth factor 1
Name Fibroblast growth factor 1
Gene Name FGF1
Pharmacological action unknown
Actions inhibitor
References
  • Deeks ED: Pazopanib: in advanced soft tissue sarcoma. Drugs. 2012 Nov 12;72(16):2129-40. doi: 10.2165/11209950-000000000-00000. - Pubmed
DTHybrid score 0.939
SH2B adapter protein 3
Name SH2B adapter protein 3
Gene Name Not Available
Pharmacological action unknown
Actions inhibitor
References
  • Deeks ED: Pazopanib: in advanced soft tissue sarcoma. Drugs. 2012 Nov 12;72(16):2129-40. doi: 10.2165/11209950-000000000-00000. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • -
  • Keisner SV, Shah SR: Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs. 2011 Mar 5;71(4):443-54. doi: 10.2165/11588960-000000000-00000. - Pubmed
  • Goh BC, Reddy NJ, Dandamudi UB, Laubscher KH, Peckham T, Hodge JP, Suttle AB, Arumugham T, Xu Y, Xu CF, Lager J, Dar MM, Lewis LD: An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified Cooperstown 5+1 cocktail in patients with advanced solid tumors. Clin Pharmacol Ther. 2010 Nov;88(5):652-9. Epub 2010 Sep 29. - Pubmed
  • Verweij J, Sleijfer S: Pazopanib , a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother. 2013 May;14(7):929-35. doi: 10.1517/14656566.2013.780030. Epub 2013 Mar 14. - Pubmed
DTHybrid score 0.7962
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Keisner SV, Shah SR: Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs. 2011 Mar 5;71(4):443-54. doi: 10.2165/11588960-000000000-00000. - Pubmed
  • Goh BC, Reddy NJ, Dandamudi UB, Laubscher KH, Peckham T, Hodge JP, Suttle AB, Arumugham T, Xu Y, Xu CF, Lager J, Dar MM, Lewis LD: An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified Cooperstown 5+1 cocktail in patients with advanced solid tumors. Clin Pharmacol Ther. 2010 Nov;88(5):652-9. Epub 2010 Sep 29. - Pubmed
DTHybrid score 0.5481
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Keisner SV, Shah SR: Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs. 2011 Mar 5;71(4):443-54. doi: 10.2165/11588960-000000000-00000. - Pubmed
  • Verweij J, Sleijfer S: Pazopanib , a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother. 2013 May;14(7):929-35. doi: 10.1517/14656566.2013.780030. Epub 2013 Mar 14. - Pubmed
DTHybrid score 0.4676
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Verweij J, Sleijfer S: Pazopanib , a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother. 2013 May;14(7):929-35. doi: 10.1517/14656566.2013.780030. Epub 2013 Mar 14. - Pubmed
DTHybrid score 0.5289

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Deng Y, Sychterz C, Suttle AB, Dar MM, Bershas D, Negash K, Qian Y, Chen EP, Gorycki PD, Ho MY: Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer. Xenobiotica. 2013 May;43(5):443-53. doi: 10.3109/00498254.2012.734642. Epub 2012 Nov 16. - Pubmed
DTHybrid score 0.6893
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Deng Y, Sychterz C, Suttle AB, Dar MM, Bershas D, Negash K, Qian Y, Chen EP, Gorycki PD, Ho MY: Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer. Xenobiotica. 2013 May;43(5):443-53. doi: 10.3109/00498254.2012.734642. Epub 2012 Nov 16. - Pubmed
DTHybrid score 0.4864
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Deeks ED: Pazopanib: in advanced soft tissue sarcoma. Drugs. 2012 Nov 12;72(16):2129-40. doi: 10.2165/11209950-000000000-00000. - Pubmed
DTHybrid score 0.3705
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions inhibitor
References
  • Deeks ED: Pazopanib: in advanced soft tissue sarcoma. Drugs. 2012 Nov 12;72(16):2129-40. doi: 10.2165/11209950-000000000-00000. - Pubmed
DTHybrid score 0.3963

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.3803
4118 Cytochrome P450 3A5 CYP3A5 0.3495
6016 Cytochrome P450 2C19 CYP2C19 0.3401
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.2235
6107 Cytochrome P450 3A7 CYP3A7 0.2226
6030 Cytochrome P450 2B6 CYP2B6 0.2162
165 FL cytokine receptor FLT3 0.1922
823 Fibroblast growth factor receptor 2 FGFR2 0.1906
1128 Alpha-2-macroglobulin A2M 0.1817
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1817
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.1742
2216 Fibroblast growth factor receptor 4 FGFR4 0.1741
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.1507
6024 Cytochrome P450 1A1 CYP1A1 0.1459
6013 Cytochrome P450 2E1 CYP2E1 0.1316
587 Serum albumin ALB 0.1313
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.1215
5787 Angiopoietin-1 receptor TEK 0.1185
1585 Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 0.1177
2164 Multidrug resistance-associated protein 4 ABCC4 0.1173
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.117
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.1156
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1101
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.1089
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.1068
1943 Hepatocyte growth factor HGF 0.106
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1046
3852 Neuropilin-1 NRP1 0.1025
2654 Complement control protein C3L 0.0975
20 Prostaglandin G/H synthase 1 PTGS1 0.0974
862 Multidrug resistance-associated protein 1 ABCC1 0.0925
1525 Heparin-binding growth factor 2 FGF2 0.0912
5718 Cytochrome P450 2A6 CYP2A6 0.0892
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.088
1618 High affinity nerve growth factor receptor NTRK1 0.0869
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0863
936 Ephrin type-A receptor 2 EPHA2 0.0846
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0838
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0835
5798 Mitogen-activated protein kinase 11 MAPK11 0.0809
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0782
776 Bile salt export pump ABCB11 0.0777
2473 Tyrosine-protein kinase CSK CSK 0.0764
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0763
1729 Solute carrier family 22 member 6 SLC22A6 0.0748
6145 Solute carrier family 22 member 1 SLC22A1 0.0714
1898 Cytochrome P450 1B1 CYP1B1 0.0675
361 Fibroblast growth factor 4 FGF4 0.066
492 Histamine H1 receptor HRH1 0.0647
2599 Tyrosine-protein kinase HCK HCK 0.0627
2530 Protein kinase C theta type PRKCQ 0.0612
6824 Tyrosine-protein kinase Lyn LYN 0.0606
6144 Solute carrier family 22 member 2 SLC22A2 0.056
824 Sodium-dependent serotonin transporter SLC6A4 0.0555
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0541
2408 Tyrosine-protein kinase SYK SYK 0.0534
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0518
290 Prostaglandin G/H synthase 2 PTGS2 0.0514
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0504
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0497
6142 Solute carrier family 22 member 8 SLC22A8 0.0494
138 Interleukin-3 IL3 0.0493
6106 Cytochrome P450 2C18 CYP2C18 0.0486
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0484
831 D(2) dopamine receptor DRD2 0.0482
556 Alpha-1A adrenergic receptor ADRA1A 0.0482
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0469
502 5-hydroxytryptamine 2A receptor HTR2A 0.0464
766 Beta-2 adrenergic receptor ADRB2 0.0436
3811 Cytochrome P450 19A1 CYP19A1 0.043
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0426
2226 Protein S100-A12 S100A12 0.0424
1048 Protein S100-A13 S100A13 0.0424
1721 Glycogen synthase kinase-3 beta GSK3B 0.0422
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0405
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.039
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.039
847 Mu-type opioid receptor OPRM1 0.0388
118 Organic cation/carnitine transporter 2 SLC22A5 0.0378
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0373
136 Estrogen receptor ESR1 0.0371
871 Glucocorticoid receptor NR3C1 0.0369
193 Beta-1 adrenergic receptor ADRB1 0.0364
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0364
318 Alpha-2A adrenergic receptor ADRA2A 0.0355
1864 RET proto-oncogene RET 0.0354
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0353
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0353
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0353
320 5-hydroxytryptamine 1A receptor HTR1A 0.035
467 Delta-type opioid receptor OPRD1 0.035
817 DNA topoisomerase 2-alpha TOP2A 0.0341
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0339
731 HIV-1 protease HIV-1 protease 0.0338
696 Kappa-type opioid receptor OPRK1 0.0332
6143 Solute carrier family 22 member 7 SLC22A7 0.0323
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0317
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0314
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0313
23 D(1A) dopamine receptor DRD1 0.0311
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0311
2240 Cell division protein kinase 2 CDK2 0.0305
844 Epidermal growth factor receptor EGFR 0.0302
3941 Amine oxidase [flavin-containing] A MAOA 0.0299
632 Alpha-1B adrenergic receptor ADRA1B 0.0294
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0293
1024 Solute carrier family 22 member 11 SLC22A11 0.0291
713 Sodium-dependent dopamine transporter SLC6A3 0.0289
590 5-hydroxytryptamine 2C receptor HTR2C 0.0289
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0289
1063 Signal transducer and activator of transcription 5B STAT5B 0.0289
6148 Multidrug resistance-associated protein 7 ABCC10 0.0288
70 Type-1 angiotensin II receptor AGTR1 0.0286
885 5-hydroxytryptamine 1B receptor HTR1B 0.0281
6147 Solute carrier family 22 member 3 SLC22A3 0.0278
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0269
6026 Alcohol dehydrogenase 6 ADH6 0.0266
3923 Cholinesterase BCHE 0.0265
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0265
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0263
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0262
5880 Thrombopoietin receptor MPL 0.0259
36 Insulin receptor INSR 0.0258
4604 Liver carboxylesterase 1 CES1 0.0254
6141 Sodium/bile acid cotransporter SLC10A1 0.0254
833 Organic cation/carnitine transporter 1 SLC22A4 0.0252
725 5-hydroxytryptamine 1D receptor HTR1D 0.0251
1353 DNA topoisomerase 1 TOP1 0.0242
3552 DNA topoisomerase 1 topA 0.0242
6137 Multidrug resistance-associated protein 6 ABCC6 0.0239
484 Tyrosine-protein kinase ABL2 ABL2 0.0238
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0234
146 Androgen receptor AR 0.0231
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0229
468 Cytochrome P450 4A11 CYP4A11 0.0223
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0221
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0217
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0216
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0214
638 D(3) dopamine receptor DRD3 0.0213
341 5-hydroxytryptamine 3 receptor HTR3A 0.0212
789 Alpha-1D adrenergic receptor ADRA1D 0.0211
117 Sterol O-acyltransferase 1 SOAT1 0.0211
1144 Hepatocyte growth factor receptor MET 0.0207
465 Calmodulin CALM1 0.0207
6182 Cytochrome P450 2J2 CYP2J2 0.02
629 Alpha-2B adrenergic receptor ADRA2B 0.0197
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0194
3810 Catechol O-methyltransferase COMT 0.0189
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0186
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0184
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0184
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0184
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0183
6031 Cytochrome P450 3A43 CYP3A43 0.0182
477 DNA topoisomerase 4 subunit A parC 0.0181
886 DNA topoisomerase 4 subunit A parC 0.0181
6226 DNA topoisomerase 4 subunit A parC 0.0181
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.018
3939 Amine oxidase [flavin-containing] B MAOB 0.018
404 DNA gyrase subunit A gyrA 0.0178
6224 DNA gyrase subunit A gyrA 0.0178
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0178
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0177
29 Tubulin beta-1 chain TUBB1 0.0176
6136 Multidrug resistance-associated protein 5 ABCC5 0.0176
869 Estrogen receptor beta ESR2 0.0176
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0172
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0172
373 Transthyretin TTR 0.017
378 Alpha-2C adrenergic receptor ADRA2C 0.0168
6220 Aryl hydrocarbon receptor AHR 0.0167
260 Cytochrome P450 51 ERG11 0.0166
761 Cytochrome P450 51 ERG11 0.0166
3163 Cytochrome P450 51 cyp51 0.0166
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0165
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0165
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0165
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0162
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0161
4120 NADPH--cytochrome P450 reductase POR 0.016
436 5-hydroxytryptamine 2B receptor HTR2B 0.0159
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0159
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0158
6102 Arylamine N-acetyltransferase 2 NAT2 0.0155
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0154
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0148
3947 Xanthine dehydrogenase/oxidase XDH 0.0146
432 D(4) dopamine receptor DRD4 0.0146
952 Dipeptidyl peptidase 4 DPP4 0.0145
474 Acetylcholinesterase ACHE 0.0141
319 Opioid receptor, sigma 1 OPRS1 0.014
756 Sex hormone-binding globulin SHBG 0.0139
33 Cystine/glutamate transporter SLC7A11 0.0139
738 Monocarboxylate transporter 1 SLC16A1 0.0137
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0137
614 Progesterone receptor PGR 0.0137
3587 Gastrotropin FABP6 0.0135
275 Arachidonate 5-lipoxygenase ALOX5 0.0135
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0135
380 Cytochrome P450 17A1 CYP17A1 0.0134
758 Thyroid hormone receptor alpha THRA 0.0132
4148 Serine/threonine-protein kinase mTOR MTOR 0.0132
2539 Tubulin alpha-1 chain TUBA4A 0.0132
890 Niemann-Pick C1-like protein 1 NPC1L1 0.013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0129
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0129
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0128
1192 Sulfotransferase 1A1 SULT1A1 0.0128
161 Tubulin beta chain TUBB 0.0124
312 Tubulin beta chain TUB2 0.0124
122 P2Y purinoceptor 12 P2RY12 0.0121
511 5-hydroxytryptamine 1F receptor HTR1F 0.0121
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0118
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0118
346 Thyroid hormone receptor beta-1 THRB 0.0117
777 Tumor necrosis factor TNF 0.0117
1760 Aminopeptidase N ANPEP 0.0117
6843 Aminopeptidase N pepN 0.0117
4122 Histone deacetylase 2 HDAC2 0.0115
818 50S ribosomal protein L10 rplJ 0.0115
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0115
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0114
124 Histamine H2 receptor HRH2 0.0114
4773 Deoxycytidine kinase DCK 0.0114
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0113
1757 Myeloperoxidase MPO 0.0112
273 Apoptosis regulator Bcl-2 BCL2 0.0111
1178 Adenosine A2a receptor ADORA2A 0.011
811 Translocator protein TSPO 0.011
904 Glutathione S-transferase P GSTP1 0.0108
6085 Fatty acid-binding protein, intestinal FABP2 0.0107
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0107
6167 Organic solute transporter subunit beta OSTB 0.0106
6166 Organic solute transporter subunit alpha OSTA 0.0106
16 Adenosine A1 receptor ADORA1 0.0106
6599 HTH-type transcriptional regulator ttgR ttgR 0.0105
992 Protein tyrosine kinase 2 beta PTK2B 0.0104
163 D(1B) dopamine receptor DRD5 0.0103
232 Corticosteroid-binding globulin SERPINA6 0.0103
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0103
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0103
716 5-hydroxytryptamine 7 receptor HTR7 0.0102
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0101
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.01
594 Thyroxine-binding globulin SERPINA7 0.01
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.01
365 Dihydrofolate reductase DHFR 0.01
2381 Dihydrofolate reductase DFR1 0.01
2833 Dihydrofolate reductase Not Available 0.01
2931 Dihydrofolate reductase folA 0.01
3544 Dihydrofolate reductase folA 0.01
3682 Dihydrofolate reductase folA 0.01
6642 Dihydrofolate reductase folA 0.01
6756 Dihydrofolate reductase dfrA 0.01
6044 Serum paraoxonase/lactonase 3 PON3 0.0099
908 Glutathione S-transferase theta-1 GSTT1 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0096
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0095
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0092
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0091
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.009
94 5-hydroxytryptamine 4 receptor HTR4 0.0089
3809 Estrogen-related receptor gamma ESRRG 0.0088
6014 Cytochrome P450 2A13 CYP2A13 0.0088
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0088
1050 Bile salt sulfotransferase SULT2A1 0.0088
1630 Integrin beta-2 ITGB2 0.0087
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0087
284 DNA-directed RNA polymerase beta chain rpoB 0.0086
5773 DNA-directed RNA polymerase beta chain rpoB 0.0086
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0086
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0085
737 Mineralocorticoid receptor NR3C2 0.0085
6020 Aldehyde oxidase AOX1 0.0085
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0084
4192 DNA topoisomerase 2-beta TOP2B 0.0083
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0083
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0082
565 Extracellular calcium-sensing receptor CASR 0.008
2112 Toll-like receptor 9 TLR9 0.0079
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0079
173 Toll-like receptor 7 TLR7 0.0079
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0078
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0078
1656 CYP2B protein CYP2B 0.0077
24 Thymidylate synthase TMP1 0.0077
359 Thymidylate synthase TYMS 0.0077
2626 Thymidylate synthase thyA 0.0077
2729 Thymidylate synthase thyA 0.0077
5352 Thymidylate synthase THYA 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
1852 Microtubule-associated protein 2 MAP2 0.0076
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0076
2449 Tubulin alpha-3 chain TUBA1A 0.0076
1010 Cytochrome P450 51A1 CYP51A1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0074
6146 High affinity copper uptake protein 1 SLC31A1 0.0074
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0074
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0074
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0074
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0074
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0073
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0073
4237 50S ribosomal protein L22 rplV 0.0073
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0072
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0071
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0071
68 Cannabinoid receptor 1 CNR1 0.0071
1629 Transcription factor AP-1 JUN 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
768 FK506-binding protein 1A FKBP1A 0.007
1256 5-hydroxytryptamine 6 receptor HTR6 0.007
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.007
131 Synaptic vesicular amine transporter SLC18A2 0.007
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0069
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0069
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0069
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0069
5300 Antigen peptide transporter 1 TAP1 0.0068
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0067
891 Dihydropteroate synthase folP 0.0067
5359 Dihydropteroate synthase folP 0.0067
7175 Dihydropteroate synthase sulI 0.0067
469 Annexin A1 ANXA1 0.0067
2183 Fatty acid-binding protein, adipocyte FABP4 0.0066
572 Integrin alpha-L ITGAL 0.0066
239 Coagulation factor X F10 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
563 Thyroid peroxidase TPO 0.0065
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0064
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0064
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0064
1650 Heme carrier protein 1 SLC46A1 0.0064
571 Melatonin receptor type 1A MTNR1A 0.0064
362 Melatonin receptor type 1B MTNR1B 0.0064
6043 Putative G-protein coupled receptor 44 GPR44 0.0064
1517 Beta-3 adrenergic receptor ADRB3 0.0064
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0063
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0063
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0063
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0063
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0063
199 Monocarboxylate transporter 8 SLC16A2 0.0063
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0063
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0062
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0062
814 Ryanodine receptor 1 RYR1 0.0061
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
3917 Methylenetetrahydrofolate reductase MTHFR 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
4203 Histamine N-methyltransferase HNMT 0.006
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
4238 50S ribosomal protein L4 rplD 0.0058
5578 50S ribosomal protein L4 rplD 0.0058
6173 50S ribosomal protein L4 rplD 0.0058
6219 50S ribosomal protein L4 rplD 0.0058
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0058
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0058
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0057
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0057
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0057
427 Substance-P receptor TACR1 0.0057
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0057
6138 Multidrug resistance protein 3 ABCB4 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0056
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0056
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0055
5923 Microtubule-associated protein tau MAPT 0.0055
5924 Microtubule-associated protein 4 MAP4 0.0055
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0055
4545 Molybdopterin-converting factor subunit 2 moaE 0.0055
4037 Hypothetical protein GPX1 0.0055
4297 Hypothetical protein SP_1951 0.0055
4521 Hypothetical protein BC_2969 0.0055
4540 Hypothetical protein TM_1070 0.0055
4555 Hypothetical protein MT1739 0.0055
4569 Hypothetical protein mshD 0.0055
4578 Hypothetical protein PA3270 0.0055
4747 Hypothetical protein PA3967 0.0055
5177 Hypothetical protein TM_0096 0.0055
5194 Hypothetical protein PA1204 0.0055
5240 Hypothetical protein Rv2991 0.0055
5370 Hypothetical protein TM_1158 0.0055
5710 Hypothetical protein Tb927.5.1360 0.0055
4527 Putative hydrolase ycdX ycdX 0.0055
4536 Transcriptional regulator, IclR family TM_0065 0.0055
4546 Aminotransferase, putative TM_1131 0.0055
2501 Protein ygbM ygbM 0.0055
4514 Citrate lyase beta subunit-like protein citE 0.0055
4781 Citrate lyase beta subunit-like protein DR_1240 0.0055
4548 Gyrase B gyrB 0.0055
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0055
4524 Mannose-6-phosphate isomerase yvyI 0.0055
6506 Stathmin-4 STMN4 0.0055
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0055
4522 Arginine N-succinyltransferase subunit alpha astA 0.0055
4547 Iron binding protein FbpA fbpA 0.0055
4538 Hypothetical protein VC1899 VC_1899 0.0055
4529 Oxalate decarboxylase oxdC oxdC 0.0055
658 Para-aminobenzoate synthase component 1 pabB 0.0055
4515 Peripheral plasma membrane protein CASK CASK 0.0055
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0054
88 Retinoic acid receptor RXR-beta RXRB 0.0054
267 Plasminogen activator inhibitor 1 SERPINE1 0.0054
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0054
528 5-hydroxytryptamine 1E receptor HTR1E 0.0053
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6149 Solute carrier family 22 member 10 SLC22A10 0.0052
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0052
712 Tubulin alpha chain TUB1 0.0052
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0052
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
4103 Proteasome subunit beta type 2 PSMB2 0.0051
4102 Proteasome subunit beta type 5 PSMB5 0.0051
4101 Proteasome subunit beta type 1 PSMB1 0.0051
6163 Copper-transporting ATPase 2 ATP7B 0.0051
6165 Copper-transporting ATPase 1 ATP7A 0.0051
461 Glycine receptor subunit alpha-3 GLRA3 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
4496 C-terminal-binding protein 1 CTBP1 0.005
896 Glutathione S-transferase Mu 1 GSTM1 0.005
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.005
1275 Estrogen sulfotransferase SULT1E1 0.005
357 Carbonic anhydrase 2 CA2 0.0049
6221 Steroid hormone receptor ERR1 ESRRA 0.0049
1541 Metalloproteinase mmp20 0.0049
3932 Glutathione S-transferase A2 GSTA2 0.0049
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0049
183 Vascular endothelial growth factor A VEGFA 0.0049
4311 tRNA TRDMT1 0.0049
4325 tRNA trmD 0.0049
4328 tRNA trmD 0.0049
856 Vitamin D3 receptor VDR 0.0048
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0048
3261 Signal recognition particle protein ffh 0.0048
4517 Probable butyrate kinase 2 buk2 0.0048
4533 Glyoxalase family protein BC_1747 0.0048
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0048
4528 Phenazine biosynthesis protein PhzD phzD1 0.0048
1648 Elastin ELN 0.0048
3759 Glutathione S-transferase gst 0.0048
4541 Glutathione S-transferase GST 0.0048
3237 Beta-lactamase OXA-2 bla 0.0048
56 Delta-aminolevulinic acid dehydratase ALAD 0.0048
2356 Delta-aminolevulinic acid dehydratase hemB 0.0048
3613 Delta-aminolevulinic acid dehydratase hemB 0.0048
3674 Delta-aminolevulinic acid dehydratase hemB 0.0048
4542 Glutaminase 1 glsA1 0.0048
4544 Glutaminase 1 glsA1 0.0048
2929 (S)-2-haloacid dehalogenase dhlB 0.0048
2995 (S)-2-haloacid dehalogenase Not Available 0.0048
4532 Gephyrin GPHN 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
6432 Transporter snf 0.0047
4692 A/G-specific adenine glycosylase mutY 0.0047
295 Carbonic anhydrase 1 CA1 0.0047
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0047
293 Gamma-glutamyl hydrolase GGH 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0045
3086 Plasmepsin-2 Not Available 0.0045
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0045
6168 Solute carrier family 22 member 16 SLC22A16 0.0045
518 Peroxidase/catalase T katG 0.0045
162 Retinoic acid receptor gamma-1 RARG 0.0044
702 UMP-CMP kinase CMPK1 0.0044
2775 Dihydroorotate dehydrogenase pyrD 0.0044
4531 Putative ketoacyl reductase actIII 0.0044
3583 6-phosphogluconolactonase pgl 0.0044
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
3467 Methylglyoxal synthase mgsA 0.0044
106 Cannabinoid receptor 2 CNR2 0.0044
3957 Adenosine deaminase ADA 0.0044
208 DNA-directed RNA polymerase beta' chain rpoC 0.0043
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0043
921 Glutamate receptor 2 GRIA2 0.0043
3937 Fatty-acid amide hydrolase FAAH 0.0043
6151 Monocarboxylate transporter 10 SLC16A10 0.0042
76 Nitric-oxide synthase, brain NOS1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0042
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0042
2021 Thrombomodulin THBD 0.0041
229 Retinoic acid receptor beta RARB 0.0041
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0041
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
2688 Peptide deformylase def 0.004
2708 Peptide deformylase def 0.004
3004 Peptide deformylase def 0.004
4337 Peptide deformylase def 0.004
4338 Peptide deformylase def 0.004
5368 Peptide deformylase def 0.004
5371 Peptide deformylase def 0.004
6375 Peptide deformylase def 0.004
6378 Peptide deformylase def 0.004
6379 Peptide deformylase def 0.004
6776 Peptide deformylase def 0.004
6900 Peptide deformylase def 0.004
4534 Cytohesin-2 CYTH2 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
5294 Nucleoside diphosphate kinase A NME1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
500 Monocarboxylate transporter 4 SLC16A3 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
5682 Ribonuclease pancreatic RNASE1 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0038
2548 Subtilisin Carlsberg apr 0.0038
592 Carbonic anhydrase 4 CA4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
634 Squalene monooxygenase SQLE 0.0038
7196 Squalene monooxygenase ERG1 0.0038
174 Sigma 1-type opioid receptor SIGMAR1 0.0038
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0038
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0038
751 Potassium channel subfamily K member 6 KCNK6 0.0038
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0038
7 Nitric oxide synthase, inducible NOS2 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
705 Glutamate receptor 1 GRIA1 0.0037
4217 Telomerase reverse transcriptase TERT 0.0036
780 Retinoic acid receptor RXR-gamma RXRG 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
84 Nuclear receptor 0B1 NR0B1 0.0035
2091 Endoplasmin HSP90B1 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0035
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
1262 Corticotropin-lipotropin POMC 0.0035
6837 Serine/threonine-protein kinase 17B STK17B 0.0035
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0035
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0035
939 50S ribosomal protein L3 rplC 0.0035
172 Potassium channel subfamily K member 1 KCNK1 0.0034
976 Platelet glycoprotein IX GP9 0.0034
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
810 Heme oxygenase 1 HMOX1 0.0034
3391 Heme oxygenase 1 pbsA1 0.0034
4226 Uridine phosphorylase 2 UPP2 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0033
581 Cytochrome P450 2R1 CYP2R1 0.0033
5626 Nucleoside diphosphate kinase B NME2 0.0033
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0032
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0032
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0032
3027 Streptavidin Not Available 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6174 50S ribosomal protein L32 rpmF 0.0031
4225 Uridine phosphorylase 1 UPP1 0.0031
482 Glycine receptor subunit alpha-1 GLRA1 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.003
6228 Nuclear receptor coactivator 1 NCOA1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
489 Monocarboxylate transporter 2 SLC16A7 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
2320 Thymidine kinase, cytosolic TK1 0.0029
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0029
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0029
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0029
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
1792 Tissue-type plasminogen activator PLAT 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0028
5818 Folate receptor alpha FOLR1 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
164 Histamine H4 receptor HRH4 0.0027
790 DNA polymerase subunit alpha B POLA2 0.0026
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0026
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0026
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
49 Endothelin B receptor EDNRB 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
5304 UPF0166 protein TM_0021 TM_0021 0.0025
5293 Shikimate kinase 2 aroL 0.0025
5266 Activator of hgdC 0.0025
5287 Signaling protein Not Available 0.0025
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0025
5292 Putative partitioning protein TT_C1605 0.0025
3199 Phosphopantetheine adenylyltransferase coaD 0.0025
3543 Phosphopantetheine adenylyltransferase coaD 0.0025
3567 Phosphopantetheine adenylyltransferase coaD 0.0025
5289 Phosphopantetheine adenylyltransferase coaD 0.0025
5281 Plasmid segregation protein parM parM 0.0025
2874 Nitrogenase iron protein 1 nifH1 0.0025
4346 Polynucleotide kinase pseT 0.0025
5283 D-alanine--D-alanine ligase B ddlB 0.0025
5288 Shikimate kinase aroK 0.0025
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0025
5299 D-alanine--D-alanine ligase ddl 0.0025
6598 D-alanine--D-alanine ligase ddl 0.0025
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0025
5276 Chromosomal replication initiator protein dnaA dnaA 0.0025
5315 Chaperone protein htpG htpG 0.0025
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0025
5259 Transcriptional regulator ntrC1 0.0025
6699 Transcriptional regulator Cgl2612 0.0025
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5284 Large T antigen Not Available 0.0025
5291 Glycogen synthase 1 glgA1 0.0025
5264 DNA replication protein REP 0.0025
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0025
5285 Kinesin heavy chain KIF5B 0.0025
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0025
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0025
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0025
5261 Phosphoribosylformylglycinamidine synthase purL 0.0025
5277 Preprotein translocase subunit secA secA 0.0025
5308 Preprotein translocase secA 1 subunit secA1 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
6859 Protein S100-A4 S100A4 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
6042 Prostaglandin reductase 2 PTGR2 0.0025
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0025
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
1374 Natriuretic peptides B NPPB 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0024
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
537 ATP synthase delta chain, mitochondrial ATP5D 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
1830 5'-nucleotidase NT5E 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
6048 Troponin C, skeletal muscle TNNC2 0.0023
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
5934 Cytochrome P450 26A1 CYP26A1 0.0023
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
340 Apoptotic protease-activating factor 1 APAF1 0.0022
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
54 Prothrombin F2 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0022
1992 Vitamin D-binding protein GC 0.0022
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0022
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0021
298 Renin REN 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.0021
291 Nitric-oxide synthase, endothelial NOS3 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
3470 Hypothetical protein MG245 homolog MPN_348 0.0021
6277 Heat shock cognate 71 kDa protein HSPA8 0.0021
5189 Trimethylamine dehydrogenase tmd 0.002
4106 Guanylate kinase GUK1 0.002
4516 Guanylate kinase gmk 0.002
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
4837 Cag-alfa cag-alfa 0.002
5646 Galactokinase GALK1 0.002
3390 Aminoglycoside 3'-phosphotransferase aphA 0.002
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.002
5302 TrwB trwB 0.002
4774 NTPase P4 Not Available 0.002
4839 DNA polymerase III subunit tau dnaX 0.002
5265 FtsH ftsH 0.002
4838 PMS1 protein homolog 2 PMS2 0.002
2270 Dephospho-CoA kinase coaE 0.002
2284 Adenylate kinase adk 0.002
2296 Adenylate kinase adk 0.002
2311 Adenylate kinase adk 0.002
2312 Adenylate kinase Not Available 0.002
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.002
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
3426 Glutamine synthetase glnA 0.002
3987 Glutamine synthetase GLUL 0.002
3175 Glutamate--cysteine ligase gshA 0.002
6459 Glycodelin PAEP 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
6126 Carbonic anhydrase 7 CA7 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.002
1058 Cell division protein kinase 5 CDK5 0.002
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.002
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
2683 Mono-ADP-ribosyltransferase C3 C3 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0019
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0019
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0019
1313 Lactoylglutathione lyase GLO1 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0019
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0019
5271 Focal adhesion kinase 1 PTK2 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
2390 Nonsecretory ribonuclease RNASE2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
5312 Kinesin-like protein KIF1A KIF1A 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
2922 Glycerol kinase glpK 0.0018
2808 Chloramphenicol acetyltransferase 3 cat3 0.0018
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0018
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0017
2207 Rhodopsin RHO 0.0017
2391 Ferrochelatase hemH 0.0017
6502 Ferrochelatase DKFZp686P18130 0.0017
1591 Ferrochelatase, mitochondrial FECH 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0017
408 Riboflavin kinase RFK 0.0017
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
2615 Chemotaxis protein cheA cheA 0.0017
2371 Pantothenate kinase coaA 0.0017
2282 Protein recA recA 0.0017
2315 Protein recA recA 0.0017
2332 Protein recA recA 0.0017
5263 Protein recA recA 0.0017
2892 Acetylglutamate kinase argB 0.0017
3550 Acetylglutamate kinase argB 0.0017
3669 Ribokinase rbsK 0.0017
1881 Hexokinase-1 HK1 0.0017
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0017
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0017
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0017
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0017
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0017
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0016
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
2727 S-adenosylmethionine synthetase metK 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
788 Creatine kinase M-type CKM 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
2697 Uridine-cytidine kinase 2 UCK2 0.0015
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0015
3233 Bile acid receptor NR1H4 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
2334 Dethiobiotin synthetase bioD 0.0015
6555 Dethiobiotin synthetase bioD 0.0015
6755 Poliovirus receptor PVR 0.0015
1360 Sphingomyelin phosphodiesterase SMPD1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
48 Pyridoxal kinase PDXK 0.0015
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
6395 Myosin-14 MYH14 0.0014
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1039 Histone deacetylase 9 HDAC9 0.0014
2251 Thymidylate kinase tmk 0.0014
2254 Thymidylate kinase DTYMK 0.0014
3522 Thymidylate kinase tmk 0.0014
1341 Histamine H3 receptor HRH3 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
1422 Serine/threonine-protein kinase 6 AURKA 0.0014
207 Glutathione synthetase GSS 0.0014
5269 Glutathione synthetase gshB 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
6218 Pannexin-1 PANX1 0.0013
3379 Kinesin-like protein KIF11 KIF11 0.0013
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6501 Fatty acid-binding protein, liver FABP1 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
3822 Actin, alpha skeletal muscle ACTA1 0.0013
444 Alcohol dehydrogenase 1B ADH1B 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
509 Thymidine kinase TK 0.0012
570 Thymidine kinase TK 0.0012
2559 Thymidine kinase TK 0.0012
3430 Thymidine kinase tdk 0.0012
3518 Thymidine kinase TK 0.0012
5301 Thymidine kinase tdk 0.0012
5771 Thymidine kinase ORF36 0.0012
7009 Thymidine kinase ORF36 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
1295 Fatty acid synthase FASN 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
719 Retinoic acid receptor responder protein 1 RARRES1 0.0012
770 Retinoic acid-induced protein 3 GPRC5A 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6500 Phospholipase A2 PLA2G1B 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
569 Retinal dehydrogenase 2 ALDH1A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
820 Glycine receptor subunit alpha-2 GLRA2 0.001
611 Retinal dehydrogenase 1 ALDH1A1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3830 Calreticulin CALR 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2298 Cytochrome P450-cam camC 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
130 Prostacyclin synthase PTGIS 0.0007
822 Aldose reductase AKR1B1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
3221 Cytochrome c4 cc4 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
798 Osteocalcin BGLAP 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
369 Coagulation factor VII F7 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
4920 Peroxidase/catalase katG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
6021 Adenosine kinase ADK 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
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