DT-Web: DB00199

Identification

Name

Erythromycin

Accession Number

DB00199 (APRD00953)

Type

small molecule

Description

Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

733.9268

Groups

approved

Monoisotopic Weight

733.461241235

Pharmacology

Indication

For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to Corynebacterium diphtheriae, in the treatment of infections due to Corynebacterium minutissimum, intestinal amebiasis caused by Entamoeba histolytica, acute pelvic inflammatory disease caused by Neisseria gonorrhoeae, skin and soft tissue infections of mild to moderate severity caused by Streptococcus pyogenes and Staphylococcus aureus, primary syphilis caused by Treponema pallidum, infections caused by Chlamydia trachomatis, nongonococcal urethritis caused by Ureaplasma urealyticum, and Legionnaires' disease caused by Legionella pneumophila.

Mechanism of action

Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the “A” or acceptor site to the “P” or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.

Absorption

Orally administered erythromycin base and its salts are readily absorbed in the microbiologically active form. Topical application of the ophthalmic ointment to the eye may result in absorption into the cornea and aqueous humor.

Protein binding

Erythromycin is largely bound to plasma proteins, ranging from 75 - 95% binding depending on the form.

Biotransformation

Hepatic. Extensively metabolized - after oral administration, less than 5% of the administered dose can be recovered in the active form in the urine. Erythromycin is partially metabolized by CYP3A4 resulting in numerous drug interactions.

Route of elimination

Not Available

Toxicity

Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.

Affected organisms

Enteric bacteria and other eubacteria

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	The macrolide, erythromycin, may increase the anticoagulant effect of acenocoumarol.
Alfentanil	The macrolide, erythromycin, may increase the effect and toxicity of alfentanil.
Alprazolam	The macrolide, erythromycin, may increase the effect of the benzodiazepine, alprazolam.
Aminophylline	The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, aminophylline.
Amiodarone	Increased risk of cardiotoxicity and arrhythmias
Anisindione	The macrolide, erythromycin, may increase the anticoagulant effect of anisindione.
Aprepitant	Erythromycin, a moderate CYP3A4 inhibitor, may increase the effect and toxicity of aprepitant.
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Astemizole	Increased risk of cardiotoxicity and arrhythmias
Atorvastatin	The macrolide, erythromycin, may increase the toxicity of the statin, atorvastatin.
Avanafil	Co-administration with the moderate CYP3A4 inhibitor erythromycin resulted in an approximate 3.6-fold increase in AUC0-inf and 2.0-fold increase in Cmax of avanafil.
Bendamustine	Decreases metabolism, thus decreasing the effects of bendamustine.
Bretylium	Increased risk of cardiotoxicity and arryhthmias
Bromazepam	Erythromcyin may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if erythromycin is initiated, discontinued or dose changed. Dosage adjustments may be required.
Bromocriptine	Erythromycin increases serum levels of bromocriptine
Buspirone	The macrolide, erythromycin, may increase the effect and toxicity of buspirone.
Cabergoline	Erythromycin increases serum levels and toxicity of cabergoline
Carbamazepine	The macrolide, erythromycin, may increase the effect of carbamazepine.
Cerivastatin	The macrolide, erythromycin, may increase the toxicity of the statin, cerivastatin.
Cilostazol	Erythromycin increases the effect of cilostazol
Cinacalcet	The macrolide, erythromycin, may increase the serum concentration and toxicity of cinacalcet.
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Citalopram	Possible serotoninergic syndrome with this combination
Clozapine	Erythromycin increases the effect of clozapine
Colchicine	Severe colchicine toxicity can occur
Cyclosporine	The macrolide, erythromycin, may increase the effect of cyclosporine.
Diazepam	The macrolide, erythromycin, may increase the effect of the benzodiazepine, diazepam.
Dicumarol	The macrolide, erythromycin, may increase the anticoagulant effect of dicumarol..
Digoxin	The macrolide, erythromycin, may increase the effect of digoxin in 10% of patients.
Dihydroergotamine	Possible ergotism and severe ischemia with this combination
Dihydroergotoxine	Possible ergotism and severe ischemia with this combination
Disopyramide	Increased risk of cardiotoxicity and arrhythmias
Docetaxel	Erythromycin may increase the serum levels and toxicity of docetaxel.
Dofetilide	Increased risk of cardiotoxicity and arrhythmias
Dyphylline	The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, dyphylline.
Eletriptan	The macrolide, erythromycin, may increase the effect and toxicity of eletriptan.
Eltrombopag	Affects hepatic CYP1A2 metabolism, increases Eltrombopag level or affect.
Eplerenone	This CYP3A4 inhibitor increases the effect and toxicity of eplerenone
Ergonovine	Possible ergotism and severe ischemia with this combination
Ergotamine	Possible ergotism and severe ischemia with this combination
Erlotinib	This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Everolimus	The macrolide, erythromycin, may increase the serum concentration and toxicity of everolimus.
Felodipine	Erythromycin increases the effect of felodipine
Fluoxetine	Possible serotoninergic syndrome with this combination
Gefitinib	This CYP3A4 inhibitor increases levels/toxicity of gefitinib
Grepafloxacin	Increased risk of cardiotoxicity and arrhythmias
Imatinib	The macrolide, erythromycin, may increase the serum concentration of imatinib.
Indacaterol	Strong inhibitors of CYP3A4 may increase levels of indacaterol. Monitor closely for adverse events.
Itraconazole	The macrolide, erythromycin, may increase the effect and toxicity of itraconazole.
Ivacaftor	Moderate CYP3A4 inhibitors may increase levels of ivacaftor. Consider dose reduction.
Levofloxacin	Increased risk of cardiotoxicity and arrhythmias
Lincomycin	Possible antagonism of action with this combination.
Lovastatin	The macrolide, erythromycin, may increase the toxicity of the statin, lovastatin.
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Methylergonovine	Possible ergotism and severe ischemia with this combination
Methylprednisolone	The macrolide, erythromycin, may increase the effect of corticosteroid, methylprednisolone.
Methysergide	Possible ergotism and severe ischemia with this combination
Midazolam	The macrolide, erythromycin, may increase the effect of the benzodiazepine, midazolam.
Moxifloxacin	Increased risk of cardiotoxicity and arrhythmias
Oxtriphylline	The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
Pazopanib	Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Pimozide	Increased risk of cardiotoxicity and arrhythmias
Pitavastatin	Erythromycin decreases metabolism of pitavastatin. Do not exceed 1 mg per day of pitavastatin or use alternative therapy.
Quetiapine	The macrolide, erythromycin, may increase the effect and toxicity of quetiapine.
Quinidine	Increased risk of cardiotoxicity and arrhythmias
Quinidine barbiturate	Increased risk of cardiotoxicity and arrhythmias
Quinupristin	This combination presents an increased risk of toxicity
Ranolazine	Increased levels of ranolazine - risk of toxicity
Repaglinide	The macrolide, erythromycin, may increase the effect of repaglinide.
Rifabutin	The rifamycin, rifabutin, may decrease the effect of the macrolide, erythromycin.
Rifampin	The rifamycin, rifampin, may decrease the effect of the macrolide, erythromycin.
Ritonavir	Increased toxicity of both agents
Roflumilast	Increases roflumilast levels.
Saxagliptin	Erythromycin is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Sertraline	Possible serotoninergic syndrome with this combination
Sibutramine	Erythromycin increases the effect and toxicity of sibutramine
Sildenafil	The macrolide, erythromycin, may increase the effect and toxicity of sildenafil.
Silodosin	Erythromycin is a moderate inhibitor of CYP3A4 and inhibits P-glycoprotein thus increasing the potential for adverse effects
Simvastatin	The macrolide, erythromycin, may increase the toxicity of the statin, simvastatin.
Sirolimus	The macrolide, erythromycin, may increase the serum concentration of sirolimus.
Sotalol	Increased risk of cardiotoxicity and arrhythmias
Sparfloxacin	Increased risk of cardiotoxicity and arrhythmias
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution. The macrolide antibiotic, erythromycin, may also increase the blood concentration of tacrolimus.
Tamsulosin	Erythromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Erythromycin is initiated, discontinued, or dose changed.
Telithromycin	Telithromycin may reduce clearance of Erythromycin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Erythromycin if Telithromycin is initiated, discontinued or dose changed.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Theophylline	The macrolide, erythromycin, may increase the effect and toxicity of theophylline.
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tolvaptan	Erythromycin is a moderate inhibitor of CYP3A4 and will considerably increase tolvaptan serum concentrations
Topotecan	The p-glycoprotein inhibitor, Erythromycin, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	Erythromycin may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone	The CYP3A4 inhibitor, Erythromycin , may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Erythromycin is initiated, discontinued or dose changed.
Triazolam	The macrolide, erythromycin, may increase the effect of the benzodiazepine, triazolam.
Trimipramine	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Valproic Acid	The macrolide antibiotic, Erythromycin, may increase the serum concentratin of Valproic acid. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Erythromycin is initiated, discontinued or dose changed.
Vardenafil	Erythromycin, a moderate CYP3A4 inhibitor, may reduce the metabolism and clearance of vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of vardenafil if erythromycin is initiated, discontinued or dose changed.
Verapamil	Erythromycin, a moderate CYP3A4 inhibitor, may increase the serum concentration of veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Monitor for changes in the therapeutic/adverse effects of verapamil if erythromycin is initiated, discontinued or dose changed.
Vinblastine	Erythromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of vinblastine if erythromycin is initiated, discontinued or dose changed.
Vincristine	Erythromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Erythromycin is initiated, discontinued or dose changed.
Vinorelbine	Erythromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinorelbine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Erythromycin is initiated, discontinued or dose changed.
Vismodegib	P-glycoprotein inhibitors may increase the chance of adverse drug reactions.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of erythromycin by decreasing its metabolism. Erythromycin may increase the serum concentration of voriconazole by decreasing its metabolism. Additive QTc prolongation may also occur. Consider alternate therapy or monitor for QTc prolongation and changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose changed.
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Warfarin	The macrolide, erythromycin, may increase the anticoagulant effect of warfarin.
Zafirlukast	Erythromycin may decrease the serum concentration and effect of zafirlukast.
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zopiclone	The macrolide antibiotic, erythromycin, may increase the serum concentration of zopiclone. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if erythromycin is initiated, discontinued or dose changed.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Take on empty stomach: 1 hour before or 2 hours after meals.
Take with a full glass of water Avoid taking with grapefruit juice.
Avoid alcohol.

23S rRNA
Name	23S rRNA
Gene Name	Not Available
Pharmacological action	yes
Actions	inhibitor
References	Moazed D, Noller HF: Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA. Biochimie. 1987 Aug;69(8):879-84. - Pubmed Schlunzen F, Zarivach R, Harms J, Bashan A, Tocilj A, Albrecht R, Yonath A, Franceschi F: Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. - Pubmed Garza-Ramos G, Xiong L, Zhong P, Mankin A: Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA. J Bacteriol. 2001 Dec;183(23):6898-907. - Pubmed
DTHybrid score	Not Available
50S ribosomal protein L22
Name	50S ribosomal protein L22
Gene Name	rplV
Pharmacological action	yes
Actions	inhibitor
References	Halling SM, Jensen AE: Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications. BMC Microbiol. 2006 Oct 2;6:84. - Pubmed Tu D, Blaha G, Moore PB, Steitz TA: Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell. 2005 Apr 22;121(2):257-70. - Pubmed Rolain JM, Raoult D: Prediction of resistance to erythromycin in the genus Rickettsia by mutations in L22 ribosomal protein. J Antimicrob Chemother. 2005 Aug;56(2):396-8. Epub 2005 Jul 4. - Pubmed Cagliero C, Mouline C, Cloeckaert A, Payot S: Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli. Antimicrob Agents Chemother. 2006 Nov;50(11):3893-6. Epub 2006 Aug 28. - Pubmed Schlunzen F, Harms JM, Franceschi F, Hansen HA, Bartels H, Zarivach R, Yonath A: Structural basis for the antibiotic activity of ketolides and azalides. Structure. 2003 Mar;11(3):329-38. - Pubmed Davydova N, Streltsov V, Wilce M, Liljas A, Garber M: L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin. J Mol Biol. 2002 Sep 20;322(3):635-44. - Pubmed
DTHybrid score	0.5782
50S ribosomal protein L4
Name	50S ribosomal protein L4
Gene Name	rplD
Pharmacological action	yes
Actions	inhibitor
References	Halling SM, Jensen AE: Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications. BMC Microbiol. 2006 Oct 2;6:84. - Pubmed Tu D, Blaha G, Moore PB, Steitz TA: Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell. 2005 Apr 22;121(2):257-70. - Pubmed O'Connor M, Gregory ST, Dahlberg AE: Multiple defects in translation associated with altered ribosomal protein L4. Nucleic Acids Res. 2004 Oct 27;32(19):5750-6. Print 2004. - Pubmed Schlunzen F, Harms JM, Franceschi F, Hansen HA, Bartels H, Zarivach R, Yonath A: Structural basis for the antibiotic activity of ketolides and azalides. Structure. 2003 Mar;11(3):329-38. - Pubmed
DTHybrid score	0.473

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score	0.7645
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.3652
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4482
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4028

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. - Pubmed Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Takano M, Hasegawa R, Fukuda T, Yumoto R, Nagai J, Murakami T: Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. Eur J Pharmacol. 1998 Oct 9;358(3):289-94. - Pubmed Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. - Pubmed Asakura E, Nakayama H, Sugie M, Zhao YL, Nadai M, Kitaichi K, Shimizu A, Miyoshi M, Takagi K, Takagi K, Hasegawa T: Azithromycin reverses anticancer drug resistance and modifies hepatobiliary excretion of doxorubicin in rats. Eur J Pharmacol. 2004 Jan 26;484(2-3):333-9. - Pubmed Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. Epub 2009 Mar 25. - Pubmed Sun H, Huang Y, Frassetto L, Benet LZ: Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metab Dispos. 2004 Nov;32(11):1239-46. Epub 2004 Jul 30. - Pubmed
DTHybrid score	0.5798
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Terashi K, Oka M, Soda H, Fukuda M, Kawabata S, Nakatomi K, Shiozawa K, Nakamura T, Tsukamoto K, Noguchi Y, Suenaga M, Tei C, Kohno S: Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells. Antimicrob Agents Chemother. 2000 Jun;44(6):1697-700. - Pubmed
DTHybrid score	0.2681
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
DTHybrid score	0.2824
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Kobayashi Y, Sakai R, Ohshiro N, Ohbayashi M, Kohyama N, Yamamoto T: Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22. Epub 2005 Feb 11. - Pubmed Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. - Pubmed
DTHybrid score	0.2217

Id	Partner name	Gene Name	Score
5578	50S ribosomal protein L4	rplD	0.473
6173	50S ribosomal protein L4	rplD	0.473
6219	50S ribosomal protein L4	rplD	0.473
4119	Cytochrome P450 2D6	CYP2D6	0.2622
4757	Cytochrome P450 2C9	CYP2C9	0.2443
6016	Cytochrome P450 2C19	CYP2C19	0.2241
4924	Cytochrome P450 2C8	CYP2C8	0.2019
5718	Cytochrome P450 2A6	CYP2A6	0.1602
818	50S ribosomal protein L10	rplJ	0.1452
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1402
6030	Cytochrome P450 2B6	CYP2B6	0.1368
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1229
587	Serum albumin	ALB	0.1185
1729	Solute carrier family 22 member 6	SLC22A6	0.1179
6024	Cytochrome P450 1A1	CYP1A1	0.1154
6142	Solute carrier family 22 member 8	SLC22A8	0.1125
6013	Cytochrome P450 2E1	CYP2E1	0.1116
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1073
776	Bile salt export pump	ABCB11	0.0798
1024	Solute carrier family 22 member 11	SLC22A11	0.0751
6145	Solute carrier family 22 member 1	SLC22A1	0.073
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0636
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0585
2164	Multidrug resistance-associated protein 4	ABCC4	0.0567
20	Prostaglandin G/H synthase 1	PTGS1	0.0558
6144	Solute carrier family 22 member 2	SLC22A2	0.0554
1898	Cytochrome P450 1B1	CYP1B1	0.0535
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0527
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0525
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0506
6141	Sodium/bile acid cotransporter	SLC10A1	0.0503
817	DNA topoisomerase 2-alpha	TOP2A	0.0502
871	Glucocorticoid receptor	NR3C1	0.05
118	Organic cation/carnitine transporter 2	SLC22A5	0.0478
492	Histamine H1 receptor	HRH1	0.0464
3811	Cytochrome P450 19A1	CYP19A1	0.0449
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0448
731	HIV-1 protease	HIV-1 protease	0.0443
6106	Cytochrome P450 2C18	CYP2C18	0.0429
290	Prostaglandin G/H synthase 2	PTGS2	0.042
6031	Cytochrome P450 3A43	CYP3A43	0.0408
6148	Multidrug resistance-associated protein 7	ABCC10	0.039
824	Sodium-dependent serotonin transporter	SLC6A4	0.0388
136	Estrogen receptor	ESR1	0.0379
847	Mu-type opioid receptor	OPRM1	0.0379
831	D(2) dopamine receptor	DRD2	0.0377
556	Alpha-1A adrenergic receptor	ADRA1A	0.0369
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0359
320	5-hydroxytryptamine 1A receptor	HTR1A	0.035
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0341
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0328
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0327
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0319
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0315
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0314
6137	Multidrug resistance-associated protein 6	ABCC6	0.0312
318	Alpha-2A adrenergic receptor	ADRA2A	0.0311
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0303
6136	Multidrug resistance-associated protein 5	ABCC5	0.0296
477	DNA topoisomerase 4 subunit A	parC	0.0294
886	DNA topoisomerase 4 subunit A	parC	0.0294
6226	DNA topoisomerase 4 subunit A	parC	0.0294
833	Organic cation/carnitine transporter 1	SLC22A4	0.029
404	DNA gyrase subunit A	gyrA	0.0289
6224	DNA gyrase subunit A	gyrA	0.0289
6147	Solute carrier family 22 member 3	SLC22A3	0.0288
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0288
467	Delta-type opioid receptor	OPRD1	0.0271
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0265
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0264
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0263
738	Monocarboxylate transporter 1	SLC16A1	0.0261
737	Mineralocorticoid receptor	NR3C2	0.026
36	Insulin receptor	INSR	0.0258
23	D(1A) dopamine receptor	DRD1	0.0252
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0248
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0248
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0248
614	Progesterone receptor	PGR	0.0247
33	Cystine/glutamate transporter	SLC7A11	0.0246
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0244
696	Kappa-type opioid receptor	OPRK1	0.0241
632	Alpha-1B adrenergic receptor	ADRA1B	0.0241
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0241
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0238
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0235
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0234
756	Sex hormone-binding globulin	SHBG	0.0231
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.023
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.023
638	D(3) dopamine receptor	DRD3	0.0229
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0229
260	Cytochrome P450 51	ERG11	0.0227
761	Cytochrome P450 51	ERG11	0.0227
3163	Cytochrome P450 51	cyp51	0.0227
3923	Cholinesterase	BCHE	0.0227
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0226
3941	Amine oxidase [flavin-containing] A	MAOA	0.0221
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0219
244	Angiotensin-converting enzyme	ACE	0.0219
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0219
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0219
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0218
766	Beta-2 adrenergic receptor	ADRB2	0.0218
193	Beta-1 adrenergic receptor	ADRB1	0.0218
468	Cytochrome P450 4A11	CYP4A11	0.0217
6020	Aldehyde oxidase	AOX1	0.0215
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0214
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.021
29	Tubulin beta-1 chain	TUBB1	0.02
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0199
380	Cytochrome P450 17A1	CYP17A1	0.0199
6182	Cytochrome P450 2J2	CYP2J2	0.0198
232	Corticosteroid-binding globulin	SERPINA6	0.0194
4604	Liver carboxylesterase 1	CES1	0.0194
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0189
869	Estrogen receptor beta	ESR2	0.0187
3947	Xanthine dehydrogenase/oxidase	XDH	0.0187
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0187
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0184
273	Apoptosis regulator Bcl-2	BCL2	0.0182
713	Sodium-dependent dopamine transporter	SLC6A3	0.0182
629	Alpha-2B adrenergic receptor	ADRA2B	0.0181
16	Adenosine A1 receptor	ADORA1	0.0181
904	Glutathione S-transferase P	GSTP1	0.018
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0178
1178	Adenosine A2a receptor	ADORA2A	0.0175
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0174
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0174
844	Epidermal growth factor receptor	EGFR	0.0173
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0171
378	Alpha-2C adrenergic receptor	ADRA2C	0.0171
789	Alpha-1D adrenergic receptor	ADRA1D	0.017
4122	Histone deacetylase 2	HDAC2	0.017
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
161	Tubulin beta chain	TUBB	0.0168
312	Tubulin beta chain	TUB2	0.0168
146	Androgen receptor	AR	0.0167
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0166
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0165
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0165
3587	Gastrotropin	FABP6	0.0164
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0164
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0163
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.016
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0158
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0158
465	Calmodulin	CALM1	0.0156
952	Dipeptidyl peptidase 4	DPP4	0.0156
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0152
1852	Microtubule-associated protein 2	MAP2	0.0149
723	Cytosolic phospholipase A2	PLA2G4A	0.0147
6220	Aryl hydrocarbon receptor	AHR	0.0142
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0141
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0139
432	D(4) dopamine receptor	DRD4	0.0136
5923	Microtubule-associated protein tau	MAPT	0.0134
5924	Microtubule-associated protein 4	MAP4	0.0134
6149	Solute carrier family 22 member 10	SLC22A10	0.0133
6167	Organic solute transporter subunit beta	OSTB	0.0133
6166	Organic solute transporter subunit alpha	OSTA	0.0132
504	Mast/stem cell growth factor receptor	KIT	0.0131
140	30S ribosomal protein S9	rpsI	0.013
6719	30S ribosomal protein S9	rpsI	0.013
6725	30S ribosomal protein S9	rpsI	0.013
3307	Acriflavine resistance protein B	acrB	0.013
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.013
3939	Amine oxidase [flavin-containing] B	MAOB	0.0129
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0127
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
4120	NADPH--cytochrome P450 reductase	POR	0.0125
373	Transthyretin	TTR	0.0124
811	Translocator protein	TSPO	0.0124
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0122
777	Tumor necrosis factor	TNF	0.0121
26	Vascular endothelial growth factor receptor 3	FLT4	0.0121
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0118
124	Histamine H2 receptor	HRH2	0.0118
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0118
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0117
32	Vascular endothelial growth factor receptor 1	FLT1	0.0115
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0114
22	30S ribosomal protein S4	rpsD	0.0113
6714	30S ribosomal protein S4	rpsD	0.0113
407	Vascular endothelial growth factor receptor 2	KDR	0.0112
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0111
716	5-hydroxytryptamine 7 receptor	HTR7	0.011
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0109
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0107
284	DNA-directed RNA polymerase beta chain	rpoB	0.0105
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0105
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0104
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0104
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0104
1010	Cytochrome P450 51A1	CYP51A1	0.0104
4773	Deoxycytidine kinase	DCK	0.0103
122	P2Y purinoceptor 12	P2RY12	0.0103
1517	Beta-3 adrenergic receptor	ADRB3	0.0102
2539	Tubulin alpha-1 chain	TUBA4A	0.0102
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0101
469	Annexin A1	ANXA1	0.0101
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.01
6014	Cytochrome P450 2A13	CYP2A13	0.01
6085	Fatty acid-binding protein, intestinal	FABP2	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0099
1353	DNA topoisomerase 1	TOP1	0.0099
3552	DNA topoisomerase 1	topA	0.0099
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0098
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0096
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0096
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0094
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0094
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0094
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0094
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0094
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0094
2449	Tubulin alpha-3 chain	TUBA1A	0.0093
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0092
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0092
1050	Bile salt sulfotransferase	SULT2A1	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0091
183	Vascular endothelial growth factor A	VEGFA	0.0091
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0091
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.009
427	Substance-P receptor	TACR1	0.009
1656	CYP2B protein	CYP2B	0.009
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0089
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0089
474	Acetylcholinesterase	ACHE	0.0089
6043	Putative G-protein coupled receptor 44	GPR44	0.0088
159	Penicillin-binding protein 2B	penA	0.0088
6121	Penicillin-binding protein 2B	penA	0.0088
5353	Glutamate decarboxylase alpha	gadA	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0087
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0086
6033	High affinity interleukin-8 receptor A	CXCR1	0.0085
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0084
1192	Sulfotransferase 1A1	SULT1A1	0.0083
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0083
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0083
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0083
275	Arachidonate 5-lipoxygenase	ALOX5	0.0082
94	5-hydroxytryptamine 4 receptor	HTR4	0.0082
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0081
338	DNA polymerase	UL30	0.0081
379	DNA polymerase	UL54	0.0081
697	DNA polymerase	ORF28	0.0081
2482	DNA polymerase	43	0.0081
4104	DNA polymerase	BALF5	0.0081
594	Thyroxine-binding globulin	SERPINA7	0.0081
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0081
163	D(1B) dopamine receptor	DRD5	0.008
6138	Multidrug resistance protein 3	ABCB4	0.008
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0078
24	Thymidylate synthase	TMP1	0.0078
359	Thymidylate synthase	TYMS	0.0078
2626	Thymidylate synthase	thyA	0.0078
2729	Thymidylate synthase	thyA	0.0078
5352	Thymidylate synthase	THYA	0.0078
4192	DNA topoisomerase 2-beta	TOP2B	0.0078
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0077
1867	Major prion protein	PRNP	0.0077
6044	Serum paraoxonase/lactonase 3	PON3	0.0076
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0076
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0075
758	Thyroid hormone receptor alpha	THRA	0.0075
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0075
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0075
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0074
70	Type-1 angiotensin II receptor	AGTR1	0.0074
705	Glutamate receptor 1	GRIA1	0.0073
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0072
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0071
165	FL cytokine receptor	FLT3	0.0071
992	Protein tyrosine kinase 2 beta	PTK2B	0.0071
663	Solute carrier family 12 member 4	SLC12A4	0.0071
53	Solute carrier family 12 member 5	SLC12A5	0.0071
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.007
239	Coagulation factor X	F10	0.0068
814	Ryanodine receptor 1	RYR1	0.0068
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0068
346	Thyroid hormone receptor beta-1	THRB	0.0067
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0067
6207	30S ribosomal protein S14	rpsN	0.0066
6209	30S ribosomal protein S19	rpsS	0.0066
6712	30S ribosomal protein S19	rpsS	0.0066
6726	30S ribosomal protein S19	rpsS	0.0066
310	Solute carrier family 12 member 2	SLC12A2	0.0066
976	Platelet glycoprotein IX	GP9	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
1629	Transcription factor AP-1	JUN	0.0065
461	Glycine receptor subunit alpha-3	GLRA3	0.0065
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0064
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0064
571	Melatonin receptor type 1A	MTNR1A	0.0064
362	Melatonin receptor type 1B	MTNR1B	0.0064
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0063
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
5787	Angiopoietin-1 receptor	TEK	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
3685	Catabolite gene activator	crp	0.0063
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0063
4655	Adenylate cyclase	cyaC	0.0063
4759	Adenylate cyclase	cyaB2	0.0063
509	Thymidine kinase	TK	0.0063
570	Thymidine kinase	TK	0.0063
2559	Thymidine kinase	TK	0.0063
3430	Thymidine kinase	tdk	0.0063
3518	Thymidine kinase	TK	0.0063
5301	Thymidine kinase	tdk	0.0063
5771	Thymidine kinase	ORF36	0.0063
7009	Thymidine kinase	ORF36	0.0063
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0062
6218	Pannexin-1	PANX1	0.0061
208	DNA-directed RNA polymerase beta' chain	rpoC	0.006
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
1630	Integrin beta-2	ITGB2	0.0059
1757	Myeloperoxidase	MPO	0.0059
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0059
489	Monocarboxylate transporter 2	SLC16A7	0.0059
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0059
365	Dihydrofolate reductase	DHFR	0.0059
2381	Dihydrofolate reductase	DFR1	0.0059
2833	Dihydrofolate reductase	Not Available	0.0059
2931	Dihydrofolate reductase	folA	0.0059
3544	Dihydrofolate reductase	folA	0.0059
3682	Dihydrofolate reductase	folA	0.0059
6642	Dihydrofolate reductase	folA	0.0059
6756	Dihydrofolate reductase	dfrA	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
3809	Estrogen-related receptor gamma	ESRRG	0.0058
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0056
6102	Arylamine N-acetyltransferase 2	NAT2	0.0056
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0056
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0055
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0055
84	Nuclear receptor 0B1	NR0B1	0.0055
2249	Aspartate aminotransferase	aspC	0.0054
2671	Aspartate aminotransferase	aspC	0.0054
5490	Aspartate aminotransferase	Not Available	0.0054
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0054
4760	Mll3241 protein	mll3241	0.0054
319	Opioid receptor, sigma 1	OPRS1	0.0054
3957	Adenosine deaminase	ADA	0.0053
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0053
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0053
1650	Heme carrier protein 1	SLC46A1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
5818	Folate receptor alpha	FOLR1	0.0052
6042	Prostaglandin reductase 2	PTGR2	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0052
5300	Antigen peptide transporter 1	TAP1	0.0051
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0051
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0051
558	Solute carrier family 12 member 1	SLC12A1	0.0051
527	Prostacyclin receptor	PTGIR	0.005
908	Glutathione S-transferase theta-1	GSTT1	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
2391	Ferrochelatase	hemH	0.005
6502	Ferrochelatase	DKFZp686P18130	0.005
1591	Ferrochelatase, mitochondrial	FECH	0.005
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0049
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0049
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0049
672	Prostaglandin F2-alpha receptor	PTGFR	0.0049
714	Glutathione reductase, mitochondrial	GSR	0.0049
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0048
1483	Membrane copper amine oxidase	AOC3	0.0048
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0048
3932	Glutathione S-transferase A2	GSTA2	0.0048
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0048
54	Prothrombin	F2	0.0048
199	Monocarboxylate transporter 8	SLC16A2	0.0047
1291	cAMP response element-binding protein	CREB1	0.0047
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0047
1313	Lactoylglutathione lyase	GLO1	0.0047
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0046
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0046
4210	Toll-like receptor 4	TLR4	0.0046
173	Toll-like receptor 7	TLR7	0.0046
867	Penicillin-binding protein 3	pbpC	0.0046
6119	Penicillin-binding protein 3	pbp3	0.0046
7154	Penicillin-binding protein 3	pbp3	0.0046
7157	Penicillin-binding protein 3	LMHCC_2184	0.0046
7162	Penicillin-binding protein 3	pbpB	0.0046
7172	Penicillin-binding protein 3	pbp3	0.0046
293	Gamma-glutamyl hydrolase	GGH	0.0046
68	Cannabinoid receptor 1	CNR1	0.0045
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0045
1654	Interleukin-1 beta	IL1B	0.0045
6212	Tubulin gamma-1 chain	TUBG1	0.0045
6210	Tubulin delta chain	TUBD1	0.0045
6211	Tubulin epsilon chain	TUBE1	0.0045
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0045
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0045
295	Carbonic anhydrase 1	CA1	0.0045
4217	Telomerase reverse transcriptase	TERT	0.0044
780	Retinoic acid receptor RXR-gamma	RXRG	0.0044
572	Integrin alpha-L	ITGAL	0.0044
1618	High affinity nerve growth factor receptor	NTRK1	0.0044
2021	Thrombomodulin	THBD	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0043
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0043
5934	Cytochrome P450 26A1	CYP26A1	0.0043
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0043
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0043
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0043
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0043
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0043
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0043
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0043
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0043
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0043
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0043
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0043
6559	Cytochrome c oxidase subunit 2	ctaC	0.0043
6669	Cytochrome c oxidase subunit 2	ctaC	0.0043
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0043
6558	Cytochrome c oxidase subunit 1	ctaD	0.0043
823	Fibroblast growth factor receptor 2	FGFR2	0.0043
921	Glutamate receptor 2	GRIA2	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
2599	Tyrosine-protein kinase HCK	HCK	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
6432	Transporter	snf	0.0041
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0041
4226	Uridine phosphorylase 2	UPP2	0.0041
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0041
3810	Catechol O-methyltransferase	COMT	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.004
88	Retinoic acid receptor RXR-beta	RXRB	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
65	Matrix metalloproteinase-9	Not Available	0.004
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0039
2540	Choloylglycine hydrolase	cbh	0.0039
4311	tRNA	TRDMT1	0.0039
4325	tRNA	trmD	0.0039
4328	tRNA	trmD	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
7	Nitric oxide synthase, inducible	NOS2	0.0039
268	Adenosine A2b receptor	ADORA2B	0.0039
5626	Nucleoside diphosphate kinase B	NME2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0038
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0038
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0038
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0037
6228	Nuclear receptor coactivator 1	NCOA1	0.0037
1039	Histone deacetylase 9	HDAC9	0.0037
6501	Fatty acid-binding protein, liver	FABP1	0.0037
4225	Uridine phosphorylase 1	UPP1	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6241	Nuclear receptor coactivator 2	NCOA2	0.0037
153	Dopamine beta-hydroxylase	DBH	0.0036
2808	Chloramphenicol acetyltransferase 3	cat3	0.0036
702	UMP-CMP kinase	CMPK1	0.0036
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0036
494	Caspase-1	CASP1	0.0036
2112	Toll-like receptor 9	TLR9	0.0036
3856	Fibroblast growth factor receptor 3	FGFR3	0.0036
4203	Histamine N-methyltransferase	HNMT	0.0036
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0036
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0036
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0036
751	Potassium channel subfamily K member 6	KCNK6	0.0036
856	Vitamin D3 receptor	VDR	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
413	Amidophosphoribosyltransferase	PPAT	0.0035
2515	Amidophosphoribosyltransferase	purF	0.0035
3714	Amidophosphoribosyltransferase	purF	0.0035
517	Alcohol dehydrogenase 1C	ADH1C	0.0035
4103	Proteasome subunit beta type 2	PSMB2	0.0035
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0035
4102	Proteasome subunit beta type 5	PSMB5	0.0035
4101	Proteasome subunit beta type 1	PSMB1	0.0035
1507	Cytochrome c	CYCS	0.0035
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
2320	Thymidine kinase, cytosolic	TK1	0.0034
131	Synaptic vesicular amine transporter	SLC18A2	0.0034
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0033
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0033
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0033
6824	Tyrosine-protein kinase Lyn	LYN	0.0033
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0033
3601	Dihydropteroate synthase 1	folP1	0.0033
3807	Dihydropteroate synthase 1	folP1	0.0033
3808	Dihydropteroate synthase 2	folP2	0.0033
2417	Chloramphenicol acetyltransferase	cat	0.0033
3278	Chloramphenicol acetyltransferase	cat	0.0033
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0033
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0033
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0033
6837	Serine/threonine-protein kinase 17B	STK17B	0.0033
172	Potassium channel subfamily K member 1	KCNK1	0.0033
3760	Penicillin-binding protein 5 precursor	dacA	0.0033
2810	Dr hemagglutinin structural subunit	draA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0032
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0032
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0032
645	Penicillin-binding protein 1A	mrcA	0.0032
5805	Penicillin-binding protein 1A	ponA	0.0032
6185	Penicillin-binding protein 1A	mrcA	0.0032
6799	Penicillin-binding protein 1A	pbpA	0.0032
5294	Nucleoside diphosphate kinase A	NME1	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
3086	Plasmepsin-2	Not Available	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
6151	Monocarboxylate transporter 10	SLC16A10	0.0032
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0031
6500	Phospholipase A2	PLA2G1B	0.0031
1864	RET proto-oncogene	RET	0.0031
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0031
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0031
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0031
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0031
162	Retinoic acid receptor gamma-1	RARG	0.003
174	Sigma 1-type opioid receptor	SIGMAR1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
1792	Tissue-type plasminogen activator	PLAT	0.003
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
2077	Caspase-3	CASP3	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
342	P protein [Includes: DNA-directed DNA polymerase	P	0.003
612	P protein [Includes: DNA-directed DNA polymerase	P	0.003
6048	Troponin C, skeletal muscle	TNNC2	0.003
936	Ephrin type-A receptor 2	EPHA2	0.0029
819	Penicillin-binding protein 4	dacB	0.0029
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0029
3639	Thymidine phosphorylase	deoA	0.0029
3936	Thymidine phosphorylase	TYMP	0.0029
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0028
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0028
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0028
115	Penicillin-binding protein 2	mrdA	0.0027
6069	Penicillin-binding protein 2	mrdA	0.0027
6118	Penicillin-binding protein 2	penA	0.0027
6187	Penicillin-binding protein 2	pbpA	0.0027
6686	Penicillin-binding protein 2	pbp2	0.0027
6939	Penicillin-binding protein 2	mrdA	0.0027
7163	Penicillin-binding protein 2	pbpA	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0027
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0026
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0026
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
1648	Elastin	ELN	0.0026
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
49	Endothelin B receptor	EDNRB	0.0026
543	Penicillin-binding protein 1B	mrcB	0.0026
6186	Penicillin-binding protein 1B	ponB	0.0026
6822	Penicillin-binding protein 1b	pbp1b	0.0026
6844	Penicillin-binding protein 1b	pbp1b	0.0026
1	Peptidoglycan synthetase ftsI	ftsI	0.0025
4155	Peptidoglycan synthetase ftsI	ftsI	0.0025
6859	Protein S100-A4	S100A4	0.0025
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0025
459	Retinoic acid receptor RXR-alpha	RXRA	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
357	Carbonic anhydrase 2	CA2	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0024
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0024
6070	Nischarin	NISCH	0.0024
719	Retinoic acid receptor responder protein 1	RARRES1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
770	Retinoic acid-induced protein 3	GPRC5A	0.0024
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0023
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0023
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0023
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
482	Glycine receptor subunit alpha-1	GLRA1	0.0023
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0023
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0023
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
332	Beta-lactamase	blaZ	0.0021
2478	Beta-lactamase	ampC	0.0021
2613	Beta-lactamase	ampC	0.0021
2635	Beta-lactamase	ampC	0.0021
2700	Beta-lactamase	penP	0.0021
5445	Beta-lactamase	blaB	0.0021
6019	Beta-lactamase	SHV-7	0.0021
6701	Beta-lactamase	cphA	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
896	Glutathione S-transferase Mu 1	GSTM1	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0021
569	Retinal dehydrogenase 2	ALDH1A2	0.0021
267	Plasminogen activator inhibitor 1	SERPINE1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0021
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.002
6168	Solute carrier family 22 member 16	SLC22A16	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6146	High affinity copper uptake protein 1	SLC31A1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
611	Retinal dehydrogenase 1	ALDH1A1	0.0019
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0019
291	Nitric-oxide synthase, endothelial	NOS3	0.0018
518	Peroxidase/catalase T	katG	0.0018
6221	Steroid hormone receptor ERR1	ESRRA	0.0018
4041	Microsomal glutathione S-transferase 2	MGST2	0.0018
1374	Natriuretic peptides B	NPPB	0.0018
1827	Gap junction alpha-1 protein	GJA1	0.0018
1908	Vascular cell adhesion protein 1	VCAM1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
563	Thyroid peroxidase	TPO	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0016
1243	Cathepsin D	CTSD	0.0016
634	Squalene monooxygenase	SQLE	0.0016
7196	Squalene monooxygenase	ERG1	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0016
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0016
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0016
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0015
3233	Bile acid receptor	NR1H4	0.0015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0015
6755	Poliovirus receptor	PVR	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0015
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
4031	Glutathione S-transferase A1	GSTA1	0.0014
1541	Metalloproteinase	mmp20	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
76	Nitric-oxide synthase, brain	NOS1	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
1275	Estrogen sulfotransferase	SULT1E1	0.0013
444	Alcohol dehydrogenase 1B	ADH1B	0.0013
760	Fibroblast growth factor 1	FGF1	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
164	Histamine H4 receptor	HRH4	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0012
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
3937	Fatty-acid amide hydrolase	FAAH	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0011
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0011
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0011
251	Alcohol dehydrogenase 1A	ADH1A	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
820	Glycine receptor subunit alpha-2	GLRA2	0.001
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.001
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.001
1928	Leukotriene C4 synthase	LTC4S	0.001
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.001
4034	Glutaredoxin-1	GLRX	0.001
910	Epididymal secretory glutathione peroxidase	GPX5	0.001
4036	Glutathione peroxidase 6	GPX6	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
4029	Microsomal glutathione S-transferase 3	MGST3	0.001
900	Glutathione S-transferase A4	GSTA4	0.001
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.001
911	Glutathione peroxidase 3	GPX3	0.001
4040	Glutathione peroxidase 7	GPX7	0.001
907	Glutathione peroxidase 2	GPX2	0.001
4032	Microsomal glutathione S-transferase 1	MGST1	0.001
906	Glutathione peroxidase 1	GPX1	0.001
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.001
4035	Glutathione S-transferase Mu 5	GSTM5	0.001
903	Glutathione S-transferase A5	GSTA5	0.001
4042	Glutathione transferase omega-2	GSTO2	0.001
4033	S-formylglutathione hydrolase	ESD	0.001
4038	Glutathione peroxidase 4	GPX4	0.001
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.001
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.001
6163	Copper-transporting ATPase 2	ATP7B	0.0009
6165	Copper-transporting ATPase 1	ATP7A	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
898	Glutathione S-transferase A3	GSTA3	0.0009
897	Glutathione S-transferase kappa 1	GSTK1	0.0009
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0009
909	Maleylacetoacetate isomerase	GSTZ1	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
899	Glutathione S-transferase Mu 3	GSTM3	0.0008
905	Glutathione transferase omega-1	GSTO1	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
3830	Calreticulin	CALR	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
2232	Interleukin-5	IL5	0.0008
2165	Glutathione S-transferase Mu 2	GSTM2	0.0008
1593	Mucin-2	MUC2	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
207	Glutathione synthetase	GSS	0.0008
5269	Glutathione synthetase	gshB	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
901	Glutathione S-transferase Mu 4	GSTM4	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
822	Aldose reductase	AKR1B1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2207	Rhodopsin	RHO	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
798	Osteocalcin	BGLAP	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
369	Coagulation factor VII	F7	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
1992	Vitamin D-binding protein	GC	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00199 - Erythromycin

Targets

Enzymes

Transporters

Predictions