DT-Web: DB00829

Identification

Name

Diazepam

Accession Number

DB00829 (APRD00642, DB07699)

Type

small molecule

Description

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

284.74

Groups

illicit

Monoisotopic Weight

284.071640755

Pharmacology

Indication

Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.

Mechanism of action

Benzodiazepines bind nonspecifically to benzodiazepine receptors which mediate sleep, affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Absorption

Essentially complete, with a bioavailability of 93%.

Protein binding

98.5%

Biotransformation

Hepatic via the Cytochrome P450 enzyme system. The main active metabolite is desmethyldiazepam, in addition to minor active metabolites including temazepam and oxazepam.

Route of elimination

Diazepam and its metabolites are excreted mainly in the urine, predominantly as their glucuronide conjugates.

Toxicity

Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amprenavir	Amprenavir may increase the effect and toxicity of the benzodiazepine, diazepam.
Cimetidine	Cimetidine may increase the effect of the benzodiazepine, diazepam.
Clarithromycin	The macrolide, clarithromycin, may increase the effect of the benzodiazepine, diazepam.
Clozapine	Increased risk of toxicity
Digoxin	The benzodiazepine, diazepam, may increase the effect of digoxin.
Erythromycin	The macrolide, erythromycin, may increase the effect of the benzodiazepine, diazepam.
Ethotoin	Ethotoin may increase the metabolism of diazepam via CYP3A4.
Etravirine	Diazepam (a CYP21C9 and CYP3A4 substrate), when administered concomitantly with etravirine, may experience an increase (via CYP21C9 inhibition) or a decrease(via CYP3A4 induction) in serum concentration. Overall clinical significance is unknown. It is recommended to monitor diazepam therapy.
Fluconazole	Fluconazole may increase the effect of the benzodiazepine, diazepam.
Fosamprenavir	Fosamprenavir may increase the effect and toxicity of the benzodiazepine, diazepam.
Fosphenytoin	Fosphenytoin may increase the metabolism of diazepam via CYP3A4.
Indinavir	The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, diazepam.
Itraconazole	Itraconazole may increase the effect of the benzodiazepine, diazepam.
Josamycin	The macrolide, josamycin, may increase the effect of the benzodiazepine, diazepam.
Kava	Kava may increase the effect of the benzodiazepine, diazepam.
Ketoconazole	Ketoconazole may increase the effect of the benzodiazepine, diazepam.
Mephenytoin	Mephenytoin may increase the metabolism of diazepam via CYP3A4.
Nelfinavir	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, diazepam.
Omeprazole	Omeprazole may increase the effect of the benzodiazepine, diazepam.
Phenytoin	Phenytoin may increase the metabolism of diazepam via CYP3A4.
Quinupristin	This combination presents an increased risk of toxicity
Rifampin	Rifampin may decrease the effect of the benzodiazepine, diazepam.
Ritonavir	The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, diazepam.
Saquinavir	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, diazepam.
St. John's Wort	St. John's Wort may decrease the effect of the benzodiazepine, diazepam.
Telithromycin	Telithromycin may reduce clearance of Diazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Diazepam if Telithromycin is initiated, discontinued or dose changed.
Ticlopidine	Ticlopidine may decrease the metabolism and clearance of Diazepam. Consider alternate therapy or monitor for adverse/toxic effects of Diazepam if Ticlopidine is initiated, discontinued or dose changed.
Tipranavir	Tipranavir may decrease the metabolism and clearance of Diazepam. Consider alternate therapy or monitor for Diazepam toxic effects if Tipranavir is initiated or dose increased.
Triprolidine	The CNS depressants, Triprolidine and Diazepam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole	Voriconazole may increase the serum concentration of diazepam by decreasing its metabolism. Monitor for diazepam toxicity if voriconazole is initiated or dose increased.

Food Interactions

Avoid taking with grapefruit or grapefruit juice as grapefruit can significantly increase serum levels of this product.
Take with food.
Avoid excessive quantities of coffee or tea (Caffeine).
Avoid alcohol.

Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed Derry JM, Dunn SM, Davies M: Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding. J Neurochem. 2004 Mar;88(6):1431-8. - Pubmed
DTHybrid score	1.1975
Gamma-aminobutyric-acid receptor subunit alpha-2
Name	Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name	GABRA2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed Derry JM, Dunn SM, Davies M: Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding. J Neurochem. 2004 Mar;88(6):1431-8. - Pubmed
DTHybrid score	1.0921
Gamma-aminobutyric-acid receptor subunit alpha-3
Name	Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name	GABRA3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed Derry JM, Dunn SM, Davies M: Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding. J Neurochem. 2004 Mar;88(6):1431-8. - Pubmed
DTHybrid score	1.0878
Gamma-aminobutyric-acid receptor subunit alpha-5
Name	Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name	GABRA5
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed Derry JM, Dunn SM, Davies M: Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding. J Neurochem. 2004 Mar;88(6):1431-8. - Pubmed
DTHybrid score	1.1098
Gamma-aminobutyric-acid receptor subunit beta-1
Name	Gamma-aminobutyric-acid receptor subunit beta-1
Gene Name	GABRB1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0618
Gamma-aminobutyric-acid receptor subunit beta-2
Name	Gamma-aminobutyric-acid receptor subunit beta-2
Gene Name	GABRB2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0463
Gamma-aminobutyric-acid receptor subunit beta-3
Name	Gamma-aminobutyric-acid receptor subunit beta-3
Gene Name	GABRB3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0625
Gamma-aminobutyric acid receptor subunit gamma-1
Name	Gamma-aminobutyric acid receptor subunit gamma-1
Gene Name	GABRG1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0581
Gamma-aminobutyric acid receptor subunit gamma-2
Name	Gamma-aminobutyric acid receptor subunit gamma-2
Gene Name	GABRG2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.08
Gamma-aminobutyric acid receptor subunit gamma-3
Name	Gamma-aminobutyric acid receptor subunit gamma-3
Gene Name	GABRG3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0285
Gamma-aminobutyric acid receptor subunit delta
Name	Gamma-aminobutyric acid receptor subunit delta
Gene Name	GABRD
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0472
Gamma-aminobutyric acid receptor subunit epsilon
Name	Gamma-aminobutyric acid receptor subunit epsilon
Gene Name	GABRE
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0454
Gamma-aminobutyric acid receptor subunit pi
Name	Gamma-aminobutyric acid receptor subunit pi
Gene Name	GABRP
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0195
Gamma-aminobutyric-acid receptor subunit rho-1
Name	Gamma-aminobutyric-acid receptor subunit rho-1
Gene Name	GABRR1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0251
Gamma-aminobutyric acid receptor subunit rho-2
Name	Gamma-aminobutyric acid receptor subunit rho-2
Gene Name	GABRR2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0304
Gamma-aminobutyric acid receptor subunit rho-3
Name	Gamma-aminobutyric acid receptor subunit rho-3
Gene Name	GABRR3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0275
Gamma-aminobutyric acid receptor subunit theta
Name	Gamma-aminobutyric acid receptor subunit theta
Gene Name	GABRQ
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.6736
Translocator protein
Name	Translocator protein
Gene Name	TSPO
Pharmacological action	unknown
Actions	potentiator
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Falchi AM, Battetta B, Sanna F, Piludu M, Sogos V, Serra M, Melis M, Putzolu M, Diaz G: Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands. Neuropharmacology. 2007 Aug;53(2):318-29. Epub 2007 Jun 2. - Pubmed
DTHybrid score	0.6176

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.4002
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6521
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.5405
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Jung F, Richardson TH, Raucy JL, Johnson EF: Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases. Drug Metab Dispos. 1997 Feb;25(2):133-9. - Pubmed
DTHybrid score	0.8416
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Jung F, Richardson TH, Raucy JL, Johnson EF: Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases. Drug Metab Dispos. 1997 Feb;25(2):133-9. - Pubmed
DTHybrid score	0.9226
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues AD, Rushmore TH, Shou M: Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):368-74. - Pubmed
DTHybrid score	0.5873
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	The Dictionary of Substances and their Effects. - Source Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6751
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3497
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6535
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5959
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Tassaneeyakul W, Birkett DJ, Miners JO: Inhibition of human hepatic cytochrome P4502E1 by azole antifungals, CNS-active drugs and non-steroidal anti-inflammatory agents. Xenobiotica. 1998 Mar;28(3):293-301. - Pubmed
DTHybrid score	0.5747

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH: In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J Pharmacol Exp Ther. 2001 Mar;296(3):723-35. - Pubmed Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed
DTHybrid score	0.6973

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.6973

Id	Partner name	Gene Name	Score
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.6913
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.657
4119	Cytochrome P450 2D6	CYP2D6	0.5653
5718	Cytochrome P450 2A6	CYP2A6	0.2487
290	Prostaglandin G/H synthase 2	PTGS2	0.2276
6024	Cytochrome P450 1A1	CYP1A1	0.2262
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.1843
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.1842
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.1779
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1662
921	Glutamate receptor 2	GRIA2	0.1623
1729	Solute carrier family 22 member 6	SLC22A6	0.1263
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1249
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1159
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1149
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1122
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.111
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1061
862	Multidrug resistance-associated protein 1	ABCC1	0.1031
6145	Solute carrier family 22 member 1	SLC22A1	0.1013
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1006
492	Histamine H1 receptor	HRH1	0.0942
824	Sodium-dependent serotonin transporter	SLC6A4	0.0914
6144	Solute carrier family 22 member 2	SLC22A2	0.0887
6031	Cytochrome P450 3A43	CYP3A43	0.0875
1898	Cytochrome P450 1B1	CYP1B1	0.084
3811	Cytochrome P450 19A1	CYP19A1	0.0824
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0807
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.08
6102	Arylamine N-acetyltransferase 2	NAT2	0.0777
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0735
831	D(2) dopamine receptor	DRD2	0.0704
556	Alpha-1A adrenergic receptor	ADRA1A	0.0695
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0678
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0665
482	Glycine receptor subunit alpha-1	GLRA1	0.0653
6142	Solute carrier family 22 member 8	SLC22A8	0.0652
776	Bile salt export pump	ABCB11	0.0627
2164	Multidrug resistance-associated protein 4	ABCC4	0.06
847	Mu-type opioid receptor	OPRM1	0.0593
468	Cytochrome P450 4A11	CYP4A11	0.0575
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0564
6143	Solute carrier family 22 member 7	SLC22A7	0.0554
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0546
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0545
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0534
23	D(1A) dopamine receptor	DRD1	0.0529
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0522
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0521
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0518
118	Organic cation/carnitine transporter 2	SLC22A5	0.0518
260	Cytochrome P450 51	ERG11	0.0518
761	Cytochrome P450 51	ERG11	0.0518
3163	Cytochrome P450 51	cyp51	0.0518
136	Estrogen receptor	ESR1	0.0516
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0511
318	Alpha-2A adrenergic receptor	ADRA2A	0.0506
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0473
871	Glucocorticoid receptor	NR3C1	0.0473
467	Delta-type opioid receptor	OPRD1	0.0463
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0458
731	HIV-1 protease	HIV-1 protease	0.0452
891	Dihydropteroate synthase	folP	0.0439
5359	Dihydropteroate synthase	folP	0.0439
7175	Dihydropteroate synthase	sulI	0.0439
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0439
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0435
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0434
696	Kappa-type opioid receptor	OPRK1	0.0426
465	Calmodulin	CALM1	0.0426
1024	Solute carrier family 22 member 11	SLC22A11	0.0417
632	Alpha-1B adrenergic receptor	ADRA1B	0.0415
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0405
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0404
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.0399
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0395
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0394
713	Sodium-dependent dopamine transporter	SLC6A3	0.0394
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0392
3923	Cholinesterase	BCHE	0.0391
3941	Amine oxidase [flavin-containing] A	MAOA	0.039
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0386
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0381
275	Arachidonate 5-lipoxygenase	ALOX5	0.0381
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0373
817	DNA topoisomerase 2-alpha	TOP2A	0.0368
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0367
461	Glycine receptor subunit alpha-3	GLRA3	0.0364
705	Glutamate receptor 1	GRIA1	0.0363
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0362
6147	Solute carrier family 22 member 3	SLC22A3	0.0359
766	Beta-2 adrenergic receptor	ADRB2	0.0358
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.034
122	P2Y purinoceptor 12	P2RY12	0.034
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.034
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0333
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.033
820	Glycine receptor subunit alpha-2	GLRA2	0.0328
36	Insulin receptor	INSR	0.0325
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0323
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0323
6020	Aldehyde oxidase	AOX1	0.0319
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0317
638	D(3) dopamine receptor	DRD3	0.0315
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0314
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0314
6182	Cytochrome P450 2J2	CYP2J2	0.0312
193	Beta-1 adrenergic receptor	ADRB1	0.0312
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0307
738	Monocarboxylate transporter 1	SLC16A1	0.0306
833	Organic cation/carnitine transporter 1	SLC22A4	0.03
1757	Myeloperoxidase	MPO	0.03
789	Alpha-1D adrenergic receptor	ADRA1D	0.0298
146	Androgen receptor	AR	0.0294
6148	Multidrug resistance-associated protein 7	ABCC10	0.0294
3939	Amine oxidase [flavin-containing] B	MAOB	0.0293
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0293
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0293
844	Epidermal growth factor receptor	EGFR	0.0292
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0288
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0284
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0283
70	Type-1 angiotensin II receptor	AGTR1	0.0283
4604	Liver carboxylesterase 1	CES1	0.0281
3426	Glutamine synthetase	glnA	0.0279
3987	Glutamine synthetase	GLUL	0.0279
756	Sex hormone-binding globulin	SHBG	0.0275
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0271
614	Progesterone receptor	PGR	0.0269
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0265
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0265
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0264
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0264
629	Alpha-2B adrenergic receptor	ADRA2B	0.026
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0259
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0255
373	Transthyretin	TTR	0.0248
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0248
3937	Fatty-acid amide hydrolase	FAAH	0.0243
380	Cytochrome P450 17A1	CYP17A1	0.0242
6141	Sodium/bile acid cotransporter	SLC10A1	0.0241
777	Tumor necrosis factor	TNF	0.024
504	Mast/stem cell growth factor receptor	KIT	0.0239
477	DNA topoisomerase 4 subunit A	parC	0.0236
886	DNA topoisomerase 4 subunit A	parC	0.0236
6226	DNA topoisomerase 4 subunit A	parC	0.0236
404	DNA gyrase subunit A	gyrA	0.0233
6224	DNA gyrase subunit A	gyrA	0.0233
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0233
6136	Multidrug resistance-associated protein 5	ABCC5	0.023
6137	Multidrug resistance-associated protein 6	ABCC6	0.0225
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0219
6220	Aryl hydrocarbon receptor	AHR	0.0218
378	Alpha-2C adrenergic receptor	ADRA2C	0.0212
869	Estrogen receptor beta	ESR2	0.0209
737	Mineralocorticoid receptor	NR3C2	0.0209
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0208
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0207
4120	NADPH--cytochrome P450 reductase	POR	0.0203
1010	Cytochrome P450 51A1	CYP51A1	0.0203
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0203
6085	Fatty acid-binding protein, intestinal	FABP2	0.0199
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0198
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
818	50S ribosomal protein L10	rplJ	0.0198
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0197
427	Substance-P receptor	TACR1	0.0195
16	Adenosine A1 receptor	ADORA1	0.0195
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0193
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0191
172	Potassium channel subfamily K member 1	KCNK1	0.0188
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0186
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0186
26	Vascular endothelial growth factor receptor 3	FLT4	0.0186
432	D(4) dopamine receptor	DRD4	0.0185
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0183
407	Vascular endothelial growth factor receptor 2	KDR	0.0182
29	Tubulin beta-1 chain	TUBB1	0.0181
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.018
124	Histamine H2 receptor	HRH2	0.018
94	5-hydroxytryptamine 4 receptor	HTR4	0.0178
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0178
716	5-hydroxytryptamine 7 receptor	HTR7	0.0178
32	Vascular endothelial growth factor receptor 1	FLT1	0.0177
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0177
6014	Cytochrome P450 2A13	CYP2A13	0.0177
489	Monocarboxylate transporter 2	SLC16A7	0.0175
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0174
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0174
1656	CYP2B protein	CYP2B	0.0171
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
1389	Transforming growth factor beta-1	TGFB1	0.0169
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0168
1178	Adenosine A2a receptor	ADORA2A	0.0168
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0165
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0163
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0163
161	Tubulin beta chain	TUBB	0.0161
312	Tubulin beta chain	TUB2	0.0161
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0157
85	Growth hormone receptor	GHR	0.0156
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0156
232	Corticosteroid-binding globulin	SERPINA6	0.0154
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0154
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0153
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0151
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
2183	Fatty acid-binding protein, adipocyte	FABP4	0.015
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0149
3808	Dihydropteroate synthase 2	folP2	0.0148
3601	Dihydropteroate synthase 1	folP1	0.0148
3807	Dihydropteroate synthase 1	folP1	0.0148
1192	Sulfotransferase 1A1	SULT1A1	0.0146
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0143
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
183	Vascular endothelial growth factor A	VEGFA	0.0141
592	Carbonic anhydrase 4	CA4	0.014
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.014
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0139
952	Dipeptidyl peptidase 4	DPP4	0.0137
3947	Xanthine dehydrogenase/oxidase	XDH	0.0137
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0136
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0134
174	Sigma 1-type opioid receptor	SIGMAR1	0.0134
6174	50S ribosomal protein L32	rpmF	0.0134
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0133
62	Glycine receptor subunit beta	GLRB	0.0132
6432	Transporter	snf	0.0132
88	Retinoic acid receptor RXR-beta	RXRB	0.0131
4116	Dihydropteroate synthetase	Not Available	0.0131
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.013
273	Apoptosis regulator Bcl-2	BCL2	0.013
4122	Histone deacetylase 2	HDAC2	0.013
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.013
723	Cytosolic phospholipase A2	PLA2G4A	0.0129
558	Solute carrier family 12 member 1	SLC12A1	0.0128
365	Dihydrofolate reductase	DHFR	0.0128
2381	Dihydrofolate reductase	DFR1	0.0128
2833	Dihydrofolate reductase	Not Available	0.0128
2931	Dihydrofolate reductase	folA	0.0128
3544	Dihydrofolate reductase	folA	0.0128
3682	Dihydrofolate reductase	folA	0.0128
6642	Dihydrofolate reductase	folA	0.0128
6756	Dihydrofolate reductase	dfrA	0.0128
823	Fibroblast growth factor receptor 2	FGFR2	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0125
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0124
1507	Cytochrome c	CYCS	0.0123
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
3932	Glutathione S-transferase A2	GSTA2	0.0122
84	Nuclear receptor 0B1	NR0B1	0.0122
1618	High affinity nerve growth factor receptor	NTRK1	0.0121
295	Carbonic anhydrase 1	CA1	0.0121
780	Retinoic acid receptor RXR-gamma	RXRG	0.0121
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.012
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.012
768	FK506-binding protein 1A	FKBP1A	0.012
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0118
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0118
500	Monocarboxylate transporter 4	SLC16A3	0.0118
1050	Bile salt sulfotransferase	SULT2A1	0.0118
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0117
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0116
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0115
2211	Fatty acid-binding protein, heart	FABP3	0.0114
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0114
357	Carbonic anhydrase 2	CA2	0.0113
2539	Tubulin alpha-1 chain	TUBA4A	0.0112
6043	Putative G-protein coupled receptor 44	GPR44	0.011
319	Opioid receptor, sigma 1	OPRS1	0.0107
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0107
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0107
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0106
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0106
3810	Catechol O-methyltransferase	COMT	0.0106
185	Vasopressin V1a receptor	AVPR1A	0.0106
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0106
4237	50S ribosomal protein L22	rplV	0.0106
2853	14 kDa fatty acid-binding protein	Not Available	0.0105
162	Retinoic acid receptor gamma-1	RARG	0.0105
163	D(1B) dopamine receptor	DRD5	0.0105
6138	Multidrug resistance protein 3	ABCB4	0.0105
322	Vasopressin V2 receptor	AVPR2	0.0104
3312	Fatty acid-binding protein, brain	FABP7	0.0104
7	Nitric oxide synthase, inducible	NOS2	0.0103
904	Glutathione S-transferase P	GSTP1	0.0102
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0102
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0101
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0101
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0101
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
474	Acetylcholinesterase	ACHE	0.01
165	FL cytokine receptor	FLT3	0.01
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0099
1353	DNA topoisomerase 1	TOP1	0.0099
3552	DNA topoisomerase 1	topA	0.0099
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0099
1648	Elastin	ELN	0.0098
239	Coagulation factor X	F10	0.0097
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0097
469	Annexin A1	ANXA1	0.0097
814	Ryanodine receptor 1	RYR1	0.0097
459	Retinoic acid receptor RXR-alpha	RXRA	0.0096
5300	Antigen peptide transporter 1	TAP1	0.0096
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
49	Endothelin B receptor	EDNRB	0.0096
251	Alcohol dehydrogenase 1A	ADH1A	0.0095
444	Alcohol dehydrogenase 1B	ADH1B	0.0095
566	Serotransferrin	TF	0.0094
4238	50S ribosomal protein L4	rplD	0.0094
5578	50S ribosomal protein L4	rplD	0.0094
6173	50S ribosomal protein L4	rplD	0.0094
6219	50S ribosomal protein L4	rplD	0.0094
1517	Beta-3 adrenergic receptor	ADRB3	0.0093
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0092
518	Peroxidase/catalase T	katG	0.0092
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0091
24	Thymidylate synthase	TMP1	0.0091
359	Thymidylate synthase	TYMS	0.0091
2626	Thymidylate synthase	thyA	0.0091
2729	Thymidylate synthase	thyA	0.0091
5352	Thymidylate synthase	THYA	0.0091
1852	Microtubule-associated protein 2	MAP2	0.0091
68	Cannabinoid receptor 1	CNR1	0.0091
153	Dopamine beta-hydroxylase	DBH	0.0091
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
1629	Transcription factor AP-1	JUN	0.009
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0089
284	DNA-directed RNA polymerase beta chain	rpoB	0.0089
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0089
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
6103	Arylamine N-acetyltransferase 1	NAT1	0.0088
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0088
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0087
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0086
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0086
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0085
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0085
244	Angiotensin-converting enzyme	ACE	0.0084
719	Retinoic acid receptor responder protein 1	RARRES1	0.0083
770	Retinoic acid-induced protein 3	GPRC5A	0.0083
33	Cystine/glutamate transporter	SLC7A11	0.0083
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0083
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0083
6149	Solute carrier family 22 member 10	SLC22A10	0.0083
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0081
1483	Membrane copper amine oxidase	AOC3	0.0081
634	Squalene monooxygenase	SQLE	0.0081
7196	Squalene monooxygenase	ERG1	0.0081
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0081
976	Platelet glycoprotein IX	GP9	0.008
1196	Complement decay-accelerating factor	CD55	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
54	Prothrombin	F2	0.0079
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
2178	Metabotropic glutamate receptor 5	GRM5	0.0078
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0078
6146	High affinity copper uptake protein 1	SLC31A1	0.0077
563	Thyroid peroxidase	TPO	0.0077
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0077
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0077
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0077
4203	Histamine N-methyltransferase	HNMT	0.0077
6044	Serum paraoxonase/lactonase 3	PON3	0.0077
3809	Estrogen-related receptor gamma	ESRRG	0.0077
4311	tRNA	TRDMT1	0.0077
4325	tRNA	trmD	0.0077
4328	tRNA	trmD	0.0077
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0076
1039	Histone deacetylase 9	HDAC9	0.0076
6126	Carbonic anhydrase 7	CA7	0.0076
4103	Proteasome subunit beta type 2	PSMB2	0.0076
4102	Proteasome subunit beta type 5	PSMB5	0.0076
4101	Proteasome subunit beta type 1	PSMB1	0.0076
1275	Estrogen sulfotransferase	SULT1E1	0.0076
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0076
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0075
517	Alcohol dehydrogenase 1C	ADH1C	0.0075
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0074
1541	Metalloproteinase	mmp20	0.0074
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0074
5787	Angiopoietin-1 receptor	TEK	0.0073
1630	Integrin beta-2	ITGB2	0.0073
569	Retinal dehydrogenase 2	ALDH1A2	0.0073
2207	Rhodopsin	RHO	0.0072
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
130	Prostacyclin synthase	PTGIS	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
5934	Cytochrome P450 26A1	CYP26A1	0.0071
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0071
908	Glutathione S-transferase theta-1	GSTT1	0.0071
5923	Microtubule-associated protein tau	MAPT	0.0071
5924	Microtubule-associated protein 4	MAP4	0.0071
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
2449	Tubulin alpha-3 chain	TUBA1A	0.007
594	Thyroxine-binding globulin	SERPINA7	0.007
2808	Chloramphenicol acetyltransferase 3	cat3	0.0069
1525	Heparin-binding growth factor 2	FGF2	0.0069
611	Retinal dehydrogenase 1	ALDH1A1	0.0068
6033	High affinity interleukin-8 receptor A	CXCR1	0.0068
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0067
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0067
4192	DNA topoisomerase 2-beta	TOP2B	0.0067
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0067
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0067
3913	Glutamic acid decarboxylase	GAD65	0.0066
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0066
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0066
856	Vitamin D3 receptor	VDR	0.0066
6766	O-GlcNAcase BT_4395	BT_4395	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0065
1992	Vitamin D-binding protein	GC	0.0065
106	Cannabinoid receptor 2	CNR2	0.0065
758	Thyroid hormone receptor alpha	THRA	0.0064
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0064
65	Matrix metalloproteinase-9	Not Available	0.0063
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
133	Dihydropterate synthase	sulI	0.0063
1864	RET proto-oncogene	RET	0.0063
2810	Dr hemagglutinin structural subunit	draA	0.0062
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0062
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0062
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0061
1714	Mitogen-activated protein kinase 3	MAPK3	0.0061
2230	Catalase	CAT	0.006
3249	Catalase	katA	0.006
3625	Catalase	katA	0.006
4539	Catalase	katA	0.006
4941	Catalase	katB	0.006
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0059
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
581	Cytochrome P450 2R1	CYP2R1	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
229	Retinoic acid receptor beta	RARB	0.0058
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0058
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0058
346	Thyroid hormone receptor beta-1	THRB	0.0058
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0057
730	Retinoic acid receptor alpha	RARA	0.0057
703	NADPH azoreductase	azr	0.0056
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0056
3904	Alanine aminotransferase 2	GPT2	0.0056
735	Alanine aminotransferase 1	GPT	0.0056
1650	Heme carrier protein 1	SLC46A1	0.0055
4773	Deoxycytidine kinase	DCK	0.0055
131	Synaptic vesicular amine transporter	SLC18A2	0.0055
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0054
3856	Fibroblast growth factor receptor 3	FGFR3	0.0054
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0054
3086	Plasmepsin-2	Not Available	0.0053
1374	Natriuretic peptides B	NPPB	0.0053
1827	Gap junction alpha-1 protein	GJA1	0.0053
1908	Vascular cell adhesion protein 1	VCAM1	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
2112	Toll-like receptor 9	TLR9	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3090	Chitosanase	csn	0.0052
936	Ephrin type-A receptor 2	EPHA2	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0052
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0052
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0052
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
3957	Adenosine deaminase	ADA	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.005
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.005
1268	Neuropeptide S receptor	NPSR1	0.005
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.005
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.005
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
267	Plasminogen activator inhibitor 1	SERPINE1	0.0049
751	Potassium channel subfamily K member 6	KCNK6	0.0048
4210	Toll-like receptor 4	TLR4	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0048
2021	Thrombomodulin	THBD	0.0048
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0047
6677	Myelin P2 protein	PMP2	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1253	Interferon gamma	IFNG	0.0046
4217	Telomerase reverse transcriptase	TERT	0.0046
199	Monocarboxylate transporter 8	SLC16A2	0.0046
173	Toll-like receptor 7	TLR7	0.0046
1291	cAMP response element-binding protein	CREB1	0.0045
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0045
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0045
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0045
572	Integrin alpha-L	ITGAL	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
6073	Potassium channel subfamily K member 9	KCNK9	0.0045
6072	Potassium channel subfamily K member 3	KCNK3	0.0045
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
6048	Troponin C, skeletal muscle	TNNC2	0.0044
1262	Corticotropin-lipotropin	POMC	0.0044
6221	Steroid hormone receptor ERR1	ESRRA	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0042
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0042
6131	Carbonic anhydrase 14	CA14	0.0041
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0041
6459	Glycodelin	PAEP	0.0041
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0041
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0041
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0041
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0041
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6824	Tyrosine-protein kinase Lyn	LYN	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0039
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0039
3639	Thymidine phosphorylase	deoA	0.0039
3936	Thymidine phosphorylase	TYMP	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0038
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0038
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
2236	Casein kinase II subunit alpha	CSNK2A1	0.0038
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0038
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0037
5798	Mitogen-activated protein kinase 11	MAPK11	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
2298	Cytochrome P450-cam	camC	0.0036
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0036
2320	Thymidine kinase, cytosolic	TK1	0.0036
291	Nitric-oxide synthase, endothelial	NOS3	0.0036
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
164	Histamine H4 receptor	HRH4	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0036
3404	Exotoxin A	eta	0.0036
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0035
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0035
4226	Uridine phosphorylase 2	UPP2	0.0035
822	Aldose reductase	AKR1B1	0.0035
358	Cystathionine beta-synthase	CBS	0.0035
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0035
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
268	Adenosine A2b receptor	ADORA2B	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0034
233	Potassium channel subfamily K member 2	KCNK2	0.0033
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
1792	Tissue-type plasminogen activator	PLAT	0.0033
896	Glutathione S-transferase Mu 1	GSTM1	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
4225	Uridine phosphorylase 1	UPP1	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0032
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0032
1867	Major prion protein	PRNP	0.0032
6218	Pannexin-1	PANX1	0.0032
3221	Cytochrome c4	cc4	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
6163	Copper-transporting ATPase 2	ATP7B	0.0031
6165	Copper-transporting ATPase 1	ATP7A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
413	Amidophosphoribosyltransferase	PPAT	0.003
2515	Amidophosphoribosyltransferase	purF	0.003
3714	Amidophosphoribosyltransferase	purF	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
283	SEC14-like protein 2	SEC14L2	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
2599	Tyrosine-protein kinase HCK	HCK	0.003
6042	Prostaglandin reductase 2	PTGR2	0.003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
2216	Fibroblast growth factor receptor 4	FGFR4	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
6500	Phospholipase A2	PLA2G1B	0.0029
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
2290	ADP-ribosyl cyclase 2	BST1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0028
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0027
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
293	Gamma-glutamyl hydrolase	GGH	0.0026
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0025
6859	Protein S100-A4	S100A4	0.0025
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
6151	Monocarboxylate transporter 10	SLC16A10	0.0025
3830	Calreticulin	CALR	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0024
4954	Soluble cytochrome b558	Not Available	0.0024
4934	Cytochrome c-551	nirM	0.0024
5218	Cytochrome c-551	nirM	0.0024
4943	Cytochrome c6	petJ	0.0024
4925	Cytochrome c-type protein SHP	shp	0.0024
4905	Cytochrome c2	Not Available	0.0024
4939	Cytochrome c2	cycA	0.0024
4964	Cytochrome c2	cycA	0.0024
4979	Cytochrome c2	cycA	0.0024
6673	Cytochrome c2	cycA	0.0024
4915	Cytochrome c-550	psbV	0.0024
4959	Cytochrome c-550	psbV	0.0024
5216	Cytochrome c-550	psbV	0.0024
4947	Bacterial hemoglobin	vhb	0.0024
4916	Cyanoglobin	glbN	0.0024
4975	Cytochrome c-556	RPA3973	0.0024
4984	Neuroglobin	NGB	0.0024
4994	Hemoglobin-like protein HbO	glbO	0.0024
4998	Hemoglobin-like protein yjbI	yjbI	0.0024
4936	Cytochrome c2 iso-2	Not Available	0.0024
4942	Diheme cytochrome c napB	napB	0.0024
4909	CooA protein	cooA	0.0024
4907	Cytochrome c-L	moxG	0.0024
6865	Cytochrome c-L	moxG	0.0024
4981	Iron-starvation protein PigA	pigA	0.0024
5000	HemO	hemO	0.0024
644	Heme oxygenase 2	HMOX2	0.0024
4982	Heme oxygenase 2	pbsA2	0.0024
4961	Hemophore HasA	hasA	0.0024
4910	Cytoglobin	CYGB	0.0024
4935	Cytochrome c-554	cycA1	0.0024
4971	Nonaheme cytochrome c	hmcA	0.0024
4976	Apocytochrome f	petA	0.0024
6407	Apocytochrome f	petA	0.0024
4904	Cytochrome c family protein	GSU1996	0.0024
4989	Cytochrome c551 peroxidase	ccp	0.0024
5222	Cytochrome c551 peroxidase	ccpA	0.0024
4931	Cytochrome P450 167A1	CYP167A1	0.0024
4999	Cytochrome P450 165B3	CYP165B3	0.0024
4764	Cytochrome P450 165C4	CYP165C4	0.0024
4960	Putative cytochrome P450-family protein	SCO7417	0.0024
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0024
4937	Cytochrome oxidase subunit II	rcoxA	0.0024
4903	Methyl-accepting chemotaxis protein	Tar4	0.0024
4972	P450cin	cinA	0.0024
4993	Hydroxylamine oxidoreductase	hao1	0.0024
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0024
4922	Cytochrome c, putative	SO_4144	0.0024
4952	Catalase/peroxidase	katA	0.0024
3093	Catalase HPII	katE	0.0024
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0024
759	Free fatty acid receptor 1	FFAR1	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6231	Pepsin A	PGA3	0.0024
4948	Cytochrome c-553	Not Available	0.0024
4923	Cytochrome c3	DvMF_2499	0.0024
4945	Cytochrome c3	Not Available	0.0024
4949	Cytochrome c3	DVU_3171	0.0024
4968	Cytochrome c3	cytc3	0.0024
4997	Cytochrome c3	SO_2727	0.0024
5219	Cytochrome c3	cyd	0.0024
4902	Nine-heme cytochrome c	Ddes_2038	0.0024
3189	High-molecular-weight cytochrome c	hmcA	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
6501	Fatty acid-binding protein, liver	FABP1	0.0023
1313	Lactoylglutathione lyase	GLO1	0.0023
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1053	BC269730_2	FADS1	0.0021
1395	Sodium/calcium exchanger 1	SLC8A1	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
400	Coagulation factor IX	F9	0.0021
5461	Coagulation factor IX	F9	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
4386	Hemoglobin-like protein HbN	glbN	0.002
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
76	Nitric-oxide synthase, brain	NOS1	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6755	Poliovirus receptor	PVR	0.002
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.002
1243	Cathepsin D	CTSD	0.0019
760	Fibroblast growth factor 1	FGF1	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0019
604	Vitamin K-dependent protein Z	PROZ	0.0019
4920	Peroxidase/catalase	katG	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
2119	Cytochrome b5	CYB5A	0.0018
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
4990	PpcA	ppcA	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
4988	Sulfite oxidase, mitochondrial	SUOX	0.0018
3375	Acidic cytochrome c3	Not Available	0.0018
4037	Hypothetical protein	GPX1	0.0018
4297	Hypothetical protein	SP_1951	0.0018
4521	Hypothetical protein	BC_2969	0.0018
4540	Hypothetical protein	TM_1070	0.0018
4555	Hypothetical protein	MT1739	0.0018
4569	Hypothetical protein	mshD	0.0018
4578	Hypothetical protein	PA3270	0.0018
4747	Hypothetical protein	PA3967	0.0018
5177	Hypothetical protein	TM_0096	0.0018
5194	Hypothetical protein	PA1204	0.0018
5240	Hypothetical protein	Rv2991	0.0018
5370	Hypothetical protein	TM_1158	0.0018
5710	Hypothetical protein	Tb927.5.1360	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
3570	Cytochrome P450 152A1	cypC	0.0018
2915	Sensor protein fixL	fixL	0.0018
4944	Sensor protein fixL	fixL	0.0018
4385	Cytochrome c'	Not Available	0.0018
4967	Cytochrome c'	cycA	0.0018
5038	Cytochrome c'	Not Available	0.0018
5223	Cytochrome c'	cycP	0.0018
4992	Cytochrome c peroxidase	Not Available	0.0018
4289	Cytochrome P450	TT_P0059	0.0018
6262	Cytochrome P450	staP	0.0018
4813	Heme oxygenase	hmuO	0.0018
5769	Heme oxygenase	Not Available	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
422	Vitamin K-dependent protein C	PROC	0.0017
1245	Vitamin K-dependent protein S	PROS1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0016
6837	Serine/threonine-protein kinase 17B	STK17B	0.0016
6228	Nuclear receptor coactivator 1	NCOA1	0.0016
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
3670	Soluble cytochrome b562 precursor	cybC	0.0015
3411	Cytochrome P450 121	cyp121	0.0015
3233	Bile acid receptor	NR1H4	0.0015
2408	Tyrosine-protein kinase SYK	SYK	0.0015
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0015
3291	Cytochrome c-552	cycA	0.0015
4927	Cytochrome c-552	nrfA	0.0015
4938	Cytochrome c-552	cycA	0.0015
4953	Cytochrome c-552	nrfA	0.0015
5217	Cytochrome c-552	cycM	0.0015
2617	Nitric oxide synthase oxygenase	nos	0.0015
2701	Nitric oxide synthase oxygenase	nos	0.0015
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
3102	Flavohemoprotein	hmp	0.0015
4969	Flavohemoprotein	hmp	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
4692	A/G-specific adenine glycosylase	mutY	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0014
6316	ADP-ribosylation factor 1	ARF1	0.0014
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
798	Osteocalcin	BGLAP	0.0014
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0014
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
2802	Endoglucanase G	celCCG	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0013
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0013
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
6168	Solute carrier family 22 member 16	SLC22A16	0.0013
4608	Putative cytochrome P450	SCO1207	0.0013
4963	Putative cytochrome P450	SCO2884	0.0013
6254	Putative cytochrome P450	SCO6998	0.0013
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0013
369	Coagulation factor VII	F7	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1295	Fatty acid synthase	FASN	0.0012
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0012
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0012
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
693	Hemoglobin subunit beta	HBB	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6268	Hydroxyacid oxidase 1	HAO1	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
810	Heme oxygenase 1	HMOX1	0.0011
3391	Heme oxygenase 1	pbsA1	0.0011
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
997	Protein kinase C beta type	PRKCB	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
1184	Interferon beta	IFNB1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
2430	Chondroitinase B	cslB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
5961	Insulin	INS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
1439	Lactotransferrin	LTF	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
2440	Endoglucanase F	celCCF	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00829 - Diazepam

Targets

Enzymes

Transporters

Carriers

Predictions