DT-Web

DB00224 - Indinavir


Identification
Name Indinavir
Accession Number DB00224 (APRD00069)
Type small molecule
Description A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 613.7895
Groups approved
Monoisotopic Weight 613.362805017
Pharmacology
Indication Indinavir is an antiretroviral drug for the treatment of HIV infection.
Mechanism of action Indinavir inhibits the HIV viral protease enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Absorption Rapidly absorbed
Protein binding 60%
Biotransformation Hepatic. Seven metabolites have been identified, one glucuronide conjugate and six oxidative metabolites. In vitro studies indicate that cytochrome P-450 3A4 (CYP3A4) is the major enzyme responsible for formation of the oxidative metabolites.
Route of elimination Less than 20% of indinavir is excreted unchanged in the urine.
Toxicity Symptoms of overdose include myocardial infarction and angina pectoris.
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Abacavir The serum concentration of Abacavir may be decreased by protease inhibitors such as Indinavir. The antiviral response should be closely monitored.
Abiraterone Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol The protease inhibitor, indinavir, may increase the anticoagulant effect of acenocoumarol.
Alprazolam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, alprazolam.
Aluminium The antacid decreases the absorption of indinavir
Amiodarone Indinavir increases the effect and toxicity of amiodarone
Anisindione The protease inhibitor, indinavir, may increase the anticoagulant effect of anisindione.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atazanavir Increased risk of hyperbilirubinemia with this association
Atorvastatin Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of atorvastatin by decreasing its metabolism. Concomitant therapy is contraindicated.
Bromazepam Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if indinavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Cabazitaxel Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Calcium Calcium may decrease the absorption of indinavir.
Carbamazepine Indinavir increases the effect and toxicity of carbamazepine
Chlordiazepoxide The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, chlordiazepoxide.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clarithromycin Indinavir may decrease the effectiveness of clarithromycin by decreasing the formatin of the active metabolite, 14-hydroxy-clarithromycin. Clarithromycin may increase the serum concentration of indinavir. Indinavir may increase the serum concentration of clarithromycin. Consider alternate therapy or monitor the efficacy and adverse effects of both agents more closely during concomitant therapy.
Clonazepam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, clonazepam.
Clorazepate The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, clorazepate.
Cyclosporine The protease inhibitor, indinavir, may increase the effect of cyclosporine.
Dantrolene Indinavir may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if indinavir is initiated, discontinued or dose changed.
Delavirdine Delavirdine may increase the effect of indinavir.
Diazepam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, diazepam.
Dicumarol The protease inhibitor, indinavir, may increase the anticoagulant effect of dicumarol.
Dihydroergotamine Indinavir may increase the serum concentration of dihydroergotamine. Concomitant therapy is contraindicated.
Efavirenz Efavirenz decreases the effect of indinavir
Ergotamine Indinavir may increase the serum concentration of ergotamine. Concomitant therapy is contraindicated.
Erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Esomeprazole Omeprazole decreases the absorption of indinavir
Estazolam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, estazolam.
Fentanyl The protease inhibitor, indinavir, may increase the effect and toxicity of fentanyl.
Flurazepam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, flurazepam.
Fusidic Acid Indinavir may increase the effect and toxicity of fusidic acid.
Halazepam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, halazepam.
Ketoconazole Indinavir may increase the serum concentration of ketoconazole. Ketoconazole may increase the serum concentration of indinavir. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if either agent is initiated, discontinued or dose changed.
Lansoprazole Omeprazole decreases the absorption of indinavir
Lovastatin Indinavir may increase the effect and toxicity of lovastatin. Concomitant therapy is contraindicated.
Lurasidone Concomitant therapy with a strong CYP3A4 inhibitor will increase level or effect of lurasidone. Coadministration with lurasidone is contraindicated.
Magnesium Magnesium may decrease the absorption of indinavir.
Magnesium oxide The antacid decreases the absorption of indinavir
Midazolam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, midazolam.
Omeprazole Omeprazole decreases the absorption of indinavir
Pantoprazole Omeprazole decreases the absorption of indinavir
Pimozide The protease inhibitor, indinavir, may increase the effect and toxicity of pimozide.
Ponatinib Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Prazepam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, prazepam.
Quazepam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, quazepam.
Quinupristin This combination presents an increased risk of toxicity
Rabeprazole Omeprazole decreases the absorption of indinavir
Ranolazine Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of ranolazine by decreasing its metabolism. Concomitant therapy is contraindicated.
Rifabutin Rifabutin decreases the effect of indinavir
Rifampin Rifampin decreases the effect of indinavir
Risperidone Increased risk of extrapyramidal symptoms
Saquinavir Possible antagonism of action
Saxagliptin Indinavir is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Sildenafil The protease inhibitor, indinavir, may increase the effect and toxicity of sildenafil.
Silodosin Indinavir is a strong inhibitor of CYP3A4 may increase the serum concentration of silodosin by decreasing its metabolism thus increases the potential for adverse side effects. Combination therapy is contraindicated.
St. John's Wort St. John's Wort decreases the effect of indinavir
Sunitinib Possible increase in sunitinib levels
Tacrolimus The protease inhibitor, Indinavir, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Indinavir therapy is initiated, discontinued or altered.
Tadalafil Indinavir may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Indinavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Tamsulosin Indinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Indinavir is initiated, discontinued, or dose changed.
Telithromycin Indinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects.
Temsirolimus Indinavir may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Indinavir, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Indinavir is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tiagabine The strong CYP3A4 inhibitor, Indinavir, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Indinavir is initiated, discontinued or dose changed.
Tolterodine Indinavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tramadol Indinavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The protease inhibitor, Indinavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism via CYP3A4. Monitor for changes in Trazodone efficacy/toxicity if Indinavir is initiated, discontinued or dose changed.
Triazolam The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, triazolam.
Trimipramine The strong CYP3A4 inhibitor, Indinavir, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Indinavir is initiated, discontinued or dose changed.
Vardenafil Indinavir, a potent CYP3A4 inhibitor, may decrease the metabolism and clearance of Vardenafil. Concomitant therapy is contraindicated.
Vemurafenib Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Venlafaxine Indinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Indinavir is initiated, discontinued, or dose changed.
Verapamil Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Indinavir is initiated, discontinued or dose changed.
Vinblastine Indinavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Indinavir is initiated, discontinued or dose changed.
Vincristine Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Indinavir is initiated, discontinued or dose changed.
Vinorelbine Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Indinavir is initiated, discontinued or dose changed.
Vitamin C Vitamin C decreases indinavir levels
Voriconazole Voriconazole may increase the serum concentration of indinavir by decreasing its metabolism. Indinavir may increase the serum concentration of voriconazole. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if doses are changed.
Warfarin The protease inhibitor, indinavir, may increase the anticoagulant effect of warfarin.
Zolpidem Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if indinavir is initiated, discontinued or dose changed.
Zonisamide Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if indinavir is initiated, discontinued or dose changed.
Zopiclone Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if indinavir is initiated, discontinued or dose changed.
Food Interactions
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Avoid excessive or chronic alcohol use.
  • Avoid taking with grapefruit juice
  • Take with a full glass of water.

Targets


HIV-1 protease
Name HIV-1 protease
Gene Name HIV-1 protease
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2007 Sep 11;. - Pubmed
  • Dandache S, Sevigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ: In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Next Generation Protease Inhibitor of Human Immunodeficiency Virus Type 1. Antimicrob Agents Chemother. 2007 Jul 16;. - Pubmed
DTHybrid score 0.366

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score 0.9487
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4217
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5393
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.54
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5918
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6186

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor,inducer
References
  • Perloff MD, von Moltke LL, Fahey JM, Daily JP, Greenblatt DJ: Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS. 2000 Jun 16;14(9):1287-9. - Pubmed
  • Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. - Pubmed
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
  • Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH: In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J Pharmacol Exp Ther. 2001 Mar;296(3):723-35. - Pubmed
  • Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR: The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998 Jan 15;101(2):289-94. - Pubmed
  • Hochman JH, Chiba M, Nishime J, Yamazaki M, Lin JH: Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4. J Pharmacol Exp Ther. 2000 Jan;292(1):310-8. - Pubmed
DTHybrid score 0.6688
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM: Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos. 2000 Mar;28(3):329-34. - Pubmed
DTHybrid score 0.2936
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor
References
  • Olson DP, Scadden DT, D'Aquila RT, De Pasquale MP: The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1). AIDS. 2002 Sep 6;16(13):1743-7. - Pubmed
DTHybrid score 0.3076
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
DTHybrid score 0.3176
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. - Pubmed
DTHybrid score 0.3366
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • Huisman MT, Smit JW, Crommentuyn KM, Zelcer N, Wiltshire HR, Beijnen JH, Schinkel AH: Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS. 2002 Nov 22;16(17):2295-301. - Pubmed
DTHybrid score 0.3265

Predictions


Id Partner name Gene Name Score
4924 Cytochrome P450 2C8 CYP2C8 0.3667
4200 Cytochrome P450 1A2 CYP1A2 0.3487
6030 Cytochrome P450 2B6 CYP2B6 0.2501
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.2299
6013 Cytochrome P450 2E1 CYP2E1 0.1772
587 Serum albumin ALB 0.1748
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1511
6024 Cytochrome P450 1A1 CYP1A1 0.1438
6144 Solute carrier family 22 member 2 SLC22A2 0.134
776 Bile salt export pump ABCB11 0.1219
1729 Solute carrier family 22 member 6 SLC22A6 0.1196
5718 Cytochrome P450 2A6 CYP2A6 0.111
20 Prostaglandin G/H synthase 1 PTGS1 0.1044
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1009
6142 Solute carrier family 22 member 8 SLC22A8 0.1006
118 Organic cation/carnitine transporter 2 SLC22A5 0.0943
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0893
492 Histamine H1 receptor HRH1 0.0893
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0869
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0868
2164 Multidrug resistance-associated protein 4 ABCC4 0.0867
824 Sodium-dependent serotonin transporter SLC6A4 0.0758
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0754
6143 Solute carrier family 22 member 7 SLC22A7 0.0749
6106 Cytochrome P450 2C18 CYP2C18 0.0744
1898 Cytochrome P450 1B1 CYP1B1 0.0695
6141 Sodium/bile acid cotransporter SLC10A1 0.069
831 D(2) dopamine receptor DRD2 0.068
6147 Solute carrier family 22 member 3 SLC22A3 0.0677
502 5-hydroxytryptamine 2A receptor HTR2A 0.0644
556 Alpha-1A adrenergic receptor ADRA1A 0.064
833 Organic cation/carnitine transporter 1 SLC22A4 0.0639
540 Sodium-dependent noradrenaline transporter SLC6A2 0.061
817 DNA topoisomerase 2-alpha TOP2A 0.0602
6148 Multidrug resistance-associated protein 7 ABCC10 0.0583
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0578
136 Estrogen receptor ESR1 0.0578
320 5-hydroxytryptamine 1A receptor HTR1A 0.0567
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0561
3811 Cytochrome P450 19A1 CYP19A1 0.0554
847 Mu-type opioid receptor OPRM1 0.0545
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0541
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0538
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0537
290 Prostaglandin G/H synthase 2 PTGS2 0.0533
766 Beta-2 adrenergic receptor ADRB2 0.0523
871 Glucocorticoid receptor NR3C1 0.0519
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0518
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0518
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.051
1024 Solute carrier family 22 member 11 SLC22A11 0.0491
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0475
6031 Cytochrome P450 3A43 CYP3A43 0.0462
23 D(1A) dopamine receptor DRD1 0.0449
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0443
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0442
632 Alpha-1B adrenergic receptor ADRA1B 0.0438
193 Beta-1 adrenergic receptor ADRB1 0.0437
341 5-hydroxytryptamine 3 receptor HTR3A 0.0432
70 Type-1 angiotensin II receptor AGTR1 0.043
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0428
6137 Multidrug resistance-associated protein 6 ABCC6 0.0427
467 Delta-type opioid receptor OPRD1 0.0417
318 Alpha-2A adrenergic receptor ADRA2A 0.0416
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0412
713 Sodium-dependent dopamine transporter SLC6A3 0.0405
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0392
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0389
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0389
696 Kappa-type opioid receptor OPRK1 0.0384
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0378
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0364
260 Cytochrome P450 51 ERG11 0.0356
761 Cytochrome P450 51 ERG11 0.0356
3163 Cytochrome P450 51 cyp51 0.0356
614 Progesterone receptor PGR 0.0356
590 5-hydroxytryptamine 2C receptor HTR2C 0.0347
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0343
3923 Cholinesterase BCHE 0.0336
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0333
6136 Multidrug resistance-associated protein 5 ABCC5 0.0328
3941 Amine oxidase [flavin-containing] A MAOA 0.0324
468 Cytochrome P450 4A11 CYP4A11 0.0322
738 Monocarboxylate transporter 1 SLC16A1 0.0321
737 Mineralocorticoid receptor NR3C2 0.0315
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0311
638 D(3) dopamine receptor DRD3 0.031
33 Cystine/glutamate transporter SLC7A11 0.031
4604 Liver carboxylesterase 1 CES1 0.0307
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0304
3587 Gastrotropin FABP6 0.0299
885 5-hydroxytryptamine 1B receptor HTR1B 0.0291
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0291
756 Sex hormone-binding globulin SHBG 0.029
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0288
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0284
450 Muscarinic acetylcholine receptor M4 CHRM4 0.028
477 DNA topoisomerase 4 subunit A parC 0.028
886 DNA topoisomerase 4 subunit A parC 0.028
6226 DNA topoisomerase 4 subunit A parC 0.028
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0279
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0278
6182 Cytochrome P450 2J2 CYP2J2 0.0276
404 DNA gyrase subunit A gyrA 0.0275
6224 DNA gyrase subunit A gyrA 0.0275
146 Androgen receptor AR 0.0275
629 Alpha-2B adrenergic receptor ADRA2B 0.0274
380 Cytochrome P450 17A1 CYP17A1 0.0272
378 Alpha-2C adrenergic receptor ADRA2C 0.0269
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0264
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0263
789 Alpha-1D adrenergic receptor ADRA1D 0.026
465 Calmodulin CALM1 0.0258
161 Tubulin beta chain TUBB 0.0255
312 Tubulin beta chain TUB2 0.0255
725 5-hydroxytryptamine 1D receptor HTR1D 0.0248
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0247
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0246
29 Tubulin beta-1 chain TUBB1 0.0245
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0244
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0244
869 Estrogen receptor beta ESR2 0.0239
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0239
3939 Amine oxidase [flavin-containing] B MAOB 0.0239
904 Glutathione S-transferase P GSTP1 0.0239
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0237
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0227
474 Acetylcholinesterase ACHE 0.0223
26 Vascular endothelial growth factor receptor 3 FLT4 0.0223
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.022
504 Mast/stem cell growth factor receptor KIT 0.0219
124 Histamine H2 receptor HRH2 0.0218
4148 Serine/threonine-protein kinase mTOR MTOR 0.0218
844 Epidermal growth factor receptor EGFR 0.0215
32 Vascular endothelial growth factor receptor 1 FLT1 0.0213
407 Vascular endothelial growth factor receptor 2 KDR 0.021
6167 Organic solute transporter subunit beta OSTB 0.0209
6166 Organic solute transporter subunit alpha OSTA 0.0208
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0208
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0207
432 D(4) dopamine receptor DRD4 0.0206
232 Corticosteroid-binding globulin SERPINA6 0.0206
122 P2Y purinoceptor 12 P2RY12 0.0205
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0201
952 Dipeptidyl peptidase 4 DPP4 0.0199
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0197
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0194
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0193
373 Transthyretin TTR 0.019
228 Beta platelet-derived growth factor receptor PDGFRB 0.0188
4120 NADPH--cytochrome P450 reductase POR 0.0188
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0188
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0186
244 Angiotensin-converting enzyme ACE 0.0184
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0182
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0182
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0182
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0181
2539 Tubulin alpha-1 chain TUBA4A 0.0178
275 Arachidonate 5-lipoxygenase ALOX5 0.0178
6220 Aryl hydrocarbon receptor AHR 0.0178
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0177
3947 Xanthine dehydrogenase/oxidase XDH 0.0176
758 Thyroid hormone receptor alpha THRA 0.0173
6085 Fatty acid-binding protein, intestinal FABP2 0.017
436 5-hydroxytryptamine 2B receptor HTR2B 0.0165
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0164
273 Apoptosis regulator Bcl-2 BCL2 0.0162
4237 50S ribosomal protein L22 rplV 0.0162
777 Tumor necrosis factor TNF 0.016
811 Translocator protein TSPO 0.016
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0159
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0157
891 Dihydropteroate synthase folP 0.0157
5359 Dihydropteroate synthase folP 0.0157
7175 Dihydropteroate synthase sulI 0.0157
4238 50S ribosomal protein L4 rplD 0.0155
5578 50S ribosomal protein L4 rplD 0.0155
6173 50S ribosomal protein L4 rplD 0.0155
6219 50S ribosomal protein L4 rplD 0.0155
1852 Microtubule-associated protein 2 MAP2 0.0155
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
346 Thyroid hormone receptor beta-1 THRB 0.0154
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0153
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0152
131 Synaptic vesicular amine transporter SLC18A2 0.0151
4773 Deoxycytidine kinase DCK 0.0149
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0149
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0149
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0149
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0149
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0148
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0148
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0148
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0148
723 Cytosolic phospholipase A2 PLA2G4A 0.0147
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0145
594 Thyroxine-binding globulin SERPINA7 0.0144
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0144
716 5-hydroxytryptamine 7 receptor HTR7 0.0143
6599 HTH-type transcriptional regulator ttgR ttgR 0.0142
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0141
5923 Microtubule-associated protein tau MAPT 0.014
5924 Microtubule-associated protein 4 MAP4 0.014
1757 Myeloperoxidase MPO 0.014
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0138
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0138
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0138
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0138
163 D(1B) dopamine receptor DRD5 0.0138
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0137
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0137
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0136
818 50S ribosomal protein L10 rplJ 0.0135
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0135
6149 Solute carrier family 22 member 10 SLC22A10 0.0135
24 Thymidylate synthase TMP1 0.0133
359 Thymidylate synthase TYMS 0.0133
2626 Thymidylate synthase thyA 0.0133
2729 Thymidylate synthase thyA 0.0133
5352 Thymidylate synthase THYA 0.0133
1010 Cytochrome P450 51A1 CYP51A1 0.0132
185 Vasopressin V1a receptor AVPR1A 0.0131
1353 DNA topoisomerase 1 TOP1 0.0131
3552 DNA topoisomerase 1 topA 0.0131
3307 Acriflavine resistance protein B acrB 0.013
768 FK506-binding protein 1A FKBP1A 0.0128
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0128
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
1656 CYP2B protein CYP2B 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
1630 Integrin beta-2 ITGB2 0.0125
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0124
469 Annexin A1 ANXA1 0.0122
1629 Transcription factor AP-1 JUN 0.0121
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0121
94 5-hydroxytryptamine 4 receptor HTR4 0.012
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.012
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
908 Glutathione S-transferase theta-1 GSTT1 0.0118
427 Substance-P receptor TACR1 0.0117
2808 Chloramphenicol acetyltransferase 3 cat3 0.0117
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0117
3810 Catechol O-methyltransferase COMT 0.0117
6014 Cytochrome P450 2A13 CYP2A13 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
365 Dihydrofolate reductase DHFR 0.0115
2381 Dihydrofolate reductase DFR1 0.0115
2833 Dihydrofolate reductase Not Available 0.0115
2931 Dihydrofolate reductase folA 0.0115
3544 Dihydrofolate reductase folA 0.0115
3682 Dihydrofolate reductase folA 0.0115
6642 Dihydrofolate reductase folA 0.0115
6756 Dihydrofolate reductase dfrA 0.0115
1517 Beta-3 adrenergic receptor ADRB3 0.0114
165 FL cytokine receptor FLT3 0.0113
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0113
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0113
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0113
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0113
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
6020 Aldehyde oxidase AOX1 0.0111
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0111
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0111
2443 Azurin azu 0.0108
1256 5-hydroxytryptamine 6 receptor HTR6 0.0107
511 5-hydroxytryptamine 1F receptor HTR1F 0.0106
1192 Sulfotransferase 1A1 SULT1A1 0.0106
1050 Bile salt sulfotransferase SULT2A1 0.0106
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0106
4122 Histone deacetylase 2 HDAC2 0.0106
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0104
2449 Tubulin alpha-3 chain TUBA1A 0.0103
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0103
183 Vascular endothelial growth factor A VEGFA 0.0101
6044 Serum paraoxonase/lactonase 3 PON3 0.0101
976 Platelet glycoprotein IX GP9 0.0101
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.01
461 Glycine receptor subunit alpha-3 GLRA3 0.01
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.01
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.01
284 DNA-directed RNA polymerase beta chain rpoB 0.0099
5773 DNA-directed RNA polymerase beta chain rpoB 0.0099
528 5-hydroxytryptamine 1E receptor HTR1E 0.0099
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0099
6102 Arylamine N-acetyltransferase 2 NAT2 0.0098
4203 Histamine N-methyltransferase HNMT 0.0098
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0097
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
295 Carbonic anhydrase 1 CA1 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0096
49 Endothelin B receptor EDNRB 0.0096
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
4192 DNA topoisomerase 2-beta TOP2B 0.0095
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0095
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0094
572 Integrin alpha-L ITGAL 0.0094
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0093
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0093
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0093
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0093
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0092
5626 Nucleoside diphosphate kinase B NME2 0.0092
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0092
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0092
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
5251 Carbonyl reductase [NADPH] 1 CBR1 0.009
578 Endothelin-1 receptor EDNRA 0.009
672 Prostaglandin F2-alpha receptor PTGFR 0.009
6146 High affinity copper uptake protein 1 SLC31A1 0.009
6138 Multidrug resistance protein 3 ABCB4 0.009
3809 Estrogen-related receptor gamma ESRRG 0.009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0088
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0088
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0088
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0088
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0088
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0088
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0087
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0087
357 Carbonic anhydrase 2 CA2 0.0086
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0086
338 DNA polymerase UL30 0.0086
379 DNA polymerase UL54 0.0086
697 DNA polymerase ORF28 0.0086
2482 DNA polymerase 43 0.0086
4104 DNA polymerase BALF5 0.0086
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0085
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0084
84 Nuclear receptor 0B1 NR0B1 0.0083
199 Monocarboxylate transporter 8 SLC16A2 0.0083
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0082
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0082
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0082
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0081
850 Vasopressin V1b receptor AVPR1B 0.0081
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0081
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
5880 Thrombopoietin receptor MPL 0.0081
1650 Heme carrier protein 1 SLC46A1 0.0081
751 Potassium channel subfamily K member 6 KCNK6 0.008
1618 High affinity nerve growth factor receptor NTRK1 0.008
2112 Toll-like receptor 9 TLR9 0.008
489 Monocarboxylate transporter 2 SLC16A7 0.008
1525 Heparin-binding growth factor 2 FGF2 0.008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0079
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0079
705 Glutamate receptor 1 GRIA1 0.0078
6043 Putative G-protein coupled receptor 44 GPR44 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0077
6210 Tubulin delta chain TUBD1 0.0077
6211 Tubulin epsilon chain TUBE1 0.0077
6212 Tubulin gamma-1 chain TUBG1 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
319 Opioid receptor, sigma 1 OPRS1 0.0077
5787 Angiopoietin-1 receptor TEK 0.0076
563 Thyroid peroxidase TPO 0.0076
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0076
153 Dopamine beta-hydroxylase DBH 0.0076
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0075
6218 Pannexin-1 PANX1 0.0075
5294 Nucleoside diphosphate kinase A NME1 0.0075
896 Glutathione S-transferase Mu 1 GSTM1 0.0075
558 Solute carrier family 12 member 1 SLC12A1 0.0074
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0074
6432 Transporter snf 0.0074
172 Potassium channel subfamily K member 1 KCNK1 0.0074
814 Ryanodine receptor 1 RYR1 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0072
239 Coagulation factor X F10 0.0072
5300 Antigen peptide transporter 1 TAP1 0.0072
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0072
1178 Adenosine A2a receptor ADORA2A 0.0071
1760 Aminopeptidase N ANPEP 0.0071
6843 Aminopeptidase N pepN 0.0071
54 Prothrombin F2 0.0071
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
921 Glutamate receptor 2 GRIA2 0.007
2981 Phospholipase A2, membrane associated PLA2G2A 0.007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.007
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0069
702 UMP-CMP kinase CMPK1 0.0069
6165 Copper-transporting ATPase 1 ATP7A 0.0069
6163 Copper-transporting ATPase 2 ATP7B 0.0069
117 Sterol O-acyltransferase 1 SOAT1 0.0069
342 P protein [Includes: DNA-directed DNA polymerase P 0.0068
612 P protein [Includes: DNA-directed DNA polymerase P 0.0068
68 Cannabinoid receptor 1 CNR1 0.0068
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0068
7 Nitric oxide synthase, inducible NOS2 0.0067
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0067
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0067
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0067
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0067
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
823 Fibroblast growth factor receptor 2 FGFR2 0.0065
1196 Complement decay-accelerating factor CD55 0.0065
3856 Fibroblast growth factor receptor 3 FGFR3 0.0065
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0064
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0064
174 Sigma 1-type opioid receptor SIGMAR1 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
3270 Elongation factor G fusA 0.0062
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
6151 Monocarboxylate transporter 10 SLC16A10 0.0062
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0062
3932 Glutathione S-transferase A2 GSTA2 0.0061
164 Histamine H4 receptor HRH4 0.0061
6168 Solute carrier family 22 member 16 SLC22A16 0.006
6126 Carbonic anhydrase 7 CA7 0.006
3611 Cytidine deaminase cdd 0.0059
3707 Cytidine deaminase cdd 0.0059
4211 Cytidine deaminase CDA 0.0059
992 Protein tyrosine kinase 2 beta PTK2B 0.0059
2232 Interleukin-5 IL5 0.0059
1593 Mucin-2 MUC2 0.0059
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0058
6171 Solute carrier family 28 member 3 SLC28A3 0.0058
5818 Folate receptor alpha FOLR1 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
2599 Tyrosine-protein kinase HCK HCK 0.0057
1864 RET proto-oncogene RET 0.0057
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0056
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0056
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0056
2021 Thrombomodulin THBD 0.0056
6174 50S ribosomal protein L32 rpmF 0.0056
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0056
780 Retinoic acid receptor RXR-gamma RXRG 0.0056
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0056
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0056
2391 Ferrochelatase hemH 0.0056
6502 Ferrochelatase DKFZp686P18130 0.0056
1591 Ferrochelatase, mitochondrial FECH 0.0056
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0055
6506 Stathmin-4 STMN4 0.0055
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0054
16 Adenosine A1 receptor ADORA1 0.0054
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0053
1313 Lactoylglutathione lyase GLO1 0.0053
6042 Prostaglandin reductase 2 PTGR2 0.0053
856 Vitamin D3 receptor VDR 0.0053
5934 Cytochrome P450 26A1 CYP26A1 0.0052
3917 Methylenetetrahydrofolate reductase MTHFR 0.0052
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0052
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0052
6837 Serine/threonine-protein kinase 17B STK17B 0.0052
2300 Lysozyme E 0.0052
3633 Lysozyme R 0.0052
5597 Lysozyme 17 0.0052
3601 Dihydropteroate synthase 1 folP1 0.0052
3807 Dihydropteroate synthase 1 folP1 0.0052
3808 Dihydropteroate synthase 2 folP2 0.0052
2417 Chloramphenicol acetyltransferase cat 0.0052
3278 Chloramphenicol acetyltransferase cat 0.0052
694 Matrix protein 2 M 0.0051
4311 tRNA TRDMT1 0.0051
4325 tRNA trmD 0.0051
4328 tRNA trmD 0.0051
88 Retinoic acid receptor RXR-beta RXRB 0.0051
2810 Dr hemagglutinin structural subunit draA 0.0051
1341 Histamine H3 receptor HRH3 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
482 Glycine receptor subunit alpha-1 GLRA1 0.005
293 Gamma-glutamyl hydrolase GGH 0.005
267 Plasminogen activator inhibitor 1 SERPINE1 0.005
4103 Proteasome subunit beta type 2 PSMB2 0.0049
4102 Proteasome subunit beta type 5 PSMB5 0.0049
4101 Proteasome subunit beta type 1 PSMB1 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0049
173 Toll-like receptor 7 TLR7 0.0049
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0049
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0048
6493 Cytochrome c oxidase subunit 6C COX6C 0.0048
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0048
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0048
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0048
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0048
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0048
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0048
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0048
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0048
6559 Cytochrome c oxidase subunit 2 ctaC 0.0048
6669 Cytochrome c oxidase subunit 2 ctaC 0.0048
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0048
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0048
6558 Cytochrome c oxidase subunit 1 ctaD 0.0048
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0048
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0048
1275 Estrogen sulfotransferase SULT1E1 0.0048
1291 cAMP response element-binding protein CREB1 0.0047
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0047
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
4210 Toll-like receptor 4 TLR4 0.0046
3086 Plasmepsin-2 Not Available 0.0046
527 Prostacyclin receptor PTGIR 0.0045
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
6221 Steroid hormone receptor ERR1 ESRRA 0.0045
6033 High affinity interleukin-8 receptor A CXCR1 0.0045
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0044
2540 Choloylglycine hydrolase cbh 0.0044
130 Prostacyclin synthase PTGIS 0.0044
517 Alcohol dehydrogenase 1C ADH1C 0.0044
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0043
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0043
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0042
1830 5'-nucleotidase NT5E 0.0042
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0042
6501 Fatty acid-binding protein, liver FABP1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
518 Peroxidase/catalase T katG 0.0041
1569 G1/S-specific cyclin-D1 CCND1 0.0041
6048 Troponin C, skeletal muscle TNNC2 0.0041
6070 Nischarin NISCH 0.0041
125 DNA polymerase beta POLB 0.0041
3913 Glutamic acid decarboxylase GAD65 0.0041
828 Phenylalanine-4-hydroxylase PAH 0.0041
3109 Phenylalanine-4-hydroxylase phhA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0041
106 Cannabinoid receptor 2 CNR2 0.004
123 Diamine acetyltransferase 1 SAT1 0.004
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.004
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0039
581 Cytochrome P450 2R1 CYP2R1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
1541 Metalloproteinase mmp20 0.0039
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0039
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1792 Tissue-type plasminogen activator PLAT 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2472 Voltage-gated potassium channel kcsA 0.0038
6366 Voltage-gated potassium channel kcsA 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
85 Growth hormone receptor GHR 0.0038
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0037
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0037
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0036
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0036
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
634 Squalene monooxygenase SQLE 0.0035
7196 Squalene monooxygenase ERG1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6500 Phospholipase A2 PLA2G1B 0.0034
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0034
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0034
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
1714 Mitogen-activated protein kinase 3 MAPK3 0.0034
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0033
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0033
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0033
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0033
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0033
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0033
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0032
936 Ephrin type-A receptor 2 EPHA2 0.0032
291 Nitric-oxide synthase, endothelial NOS3 0.0032
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6228 Nuclear receptor coactivator 1 NCOA1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
719 Retinoic acid receptor responder protein 1 RARRES1 0.003
770 Retinoic acid-induced protein 3 GPRC5A 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
5126 Arginase rocF 0.0029
760 Fibroblast growth factor 1 FGF1 0.0029
1360 Sphingomyelin phosphodiesterase SMPD1 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0029
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1992 Vitamin D-binding protein GC 0.0028
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
484 Tyrosine-protein kinase ABL2 ABL2 0.0027
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0027
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
537 ATP synthase delta chain, mitochondrial ATP5D 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0026
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0026
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0026
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
162 Retinoic acid receptor gamma-1 RARG 0.0026
569 Retinal dehydrogenase 2 ALDH1A2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
551 Carnitine O-acetyltransferase CRAT 0.0025
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0025
605 Fumarate reductase flavoprotein subunit frdA 0.0025
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0025
3673 Fumarate reductase flavoprotein subunit fccA 0.0025
4912 Fumarate reductase flavoprotein subunit ifcA 0.0025
6549 Fumarate reductase flavoprotein subunit frdA 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4217 Telomerase reverse transcriptase TERT 0.0025
1648 Elastin ELN 0.0024
4041 Microsomal glutathione S-transferase 2 MGST2 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
76 Nitric-oxide synthase, brain NOS1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1374 Natriuretic peptides B NPPB 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0023
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0023
5816 Cadherin-5 CDH5 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
1262 Corticotropin-lipotropin POMC 0.0022
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0022
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0022
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0022
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0022
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
298 Renin REN 0.0021
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
5798 Mitogen-activated protein kinase 11 MAPK11 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
4031 Glutathione S-transferase A1 GSTA1 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
1039 Histone deacetylase 9 HDAC9 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
3957 Adenosine deaminase ADA 0.0019
444 Alcohol dehydrogenase 1B ADH1B 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
251 Alcohol dehydrogenase 1A ADH1A 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0017
1928 Leukotriene C4 synthase LTC4S 0.0017
4034 Glutaredoxin-1 GLRX 0.0017
910 Epididymal secretory glutathione peroxidase GPX5 0.0017
4037 Hypothetical protein GPX1 0.0017
4297 Hypothetical protein SP_1951 0.0017
4521 Hypothetical protein BC_2969 0.0017
4540 Hypothetical protein TM_1070 0.0017
4555 Hypothetical protein MT1739 0.0017
4569 Hypothetical protein mshD 0.0017
4578 Hypothetical protein PA3270 0.0017
4747 Hypothetical protein PA3967 0.0017
5177 Hypothetical protein TM_0096 0.0017
5194 Hypothetical protein PA1204 0.0017
5240 Hypothetical protein Rv2991 0.0017
5370 Hypothetical protein TM_1158 0.0017
5710 Hypothetical protein Tb927.5.1360 0.0017
4029 Microsomal glutathione S-transferase 3 MGST3 0.0017
4036 Glutathione peroxidase 6 GPX6 0.0017
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0017
4032 Microsomal glutathione S-transferase 1 MGST1 0.0017
903 Glutathione S-transferase A5 GSTA5 0.0017
4040 Glutathione peroxidase 7 GPX7 0.0017
907 Glutathione peroxidase 2 GPX2 0.0017
900 Glutathione S-transferase A4 GSTA4 0.0017
911 Glutathione peroxidase 3 GPX3 0.0017
906 Glutathione peroxidase 1 GPX1 0.0017
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0017
4035 Glutathione S-transferase Mu 5 GSTM5 0.0017
4042 Glutathione transferase omega-2 GSTO2 0.0017
4038 Glutathione peroxidase 4 GPX4 0.0017
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0017
4033 S-formylglutathione hydrolase ESD 0.0017
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
3830 Calreticulin CALR 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
3924 Phospholipase D1 PLD1 0.0016
820 Glycine receptor subunit alpha-2 GLRA2 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
2183 Fatty acid-binding protein, adipocyte FABP4 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
3319 Hydroxyacylglutathione hydrolase HAGH 0.0016
6036 Eosinophil peroxidase EPX 0.0016
898 Glutathione S-transferase A3 GSTA3 0.0016
897 Glutathione S-transferase kappa 1 GSTK1 0.0015
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
277 Purine nucleoside phosphorylase PNP 0.0015
2870 Purine nucleoside phosphorylase punA 0.0015
2945 Purine nucleoside phosphorylase punA 0.0015
4659 Purine nucleoside phosphorylase TM_1596 0.0015
4825 Purine nucleoside phosphorylase TTHA1435 0.0015
6755 Poliovirus receptor PVR 0.0015
909 Maleylacetoacetate isomerase GSTZ1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0015
899 Glutathione S-transferase Mu 3 GSTM3 0.0015
905 Glutathione transferase omega-1 GSTO1 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
268 Adenosine A2b receptor ADORA2B 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
2165 Glutathione S-transferase Mu 2 GSTM2 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
207 Glutathione synthetase GSS 0.0013
5269 Glutathione synthetase gshB 0.0013
2207 Rhodopsin RHO 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
901 Glutathione S-transferase Mu 4 GSTM4 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
292 Activin receptor type-1 ACVR1 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
6859 Protein S100-A4 S100A4 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
714 Glutathione reductase, mitochondrial GSR 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6459 Glycodelin PAEP 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
3221 Cytochrome c4 cc4 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
2298 Cytochrome P450-cam camC 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
6677 Myelin P2 protein PMP2 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1507 Cytochrome c CYCS 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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