DT-Web: DB01068

Identification

Name

Clonazepam

Accession Number

DB01068 (APRD00054)

Type

small molecule

Description

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

315.711

Groups

illicit

Monoisotopic Weight

315.041068908

Pharmacology

Indication

Clonazepam is used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. It can also be used for the treatment of panic disorders.

Mechanism of action

Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

Absorption

Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%. Cmax, oral administration = 1 -4 hours.

Protein binding

85% bound to plasma proteins.

Biotransformation

Hepatic (cytochrome P450, including CYP3A). Biotransformation occurs mainly by reduction of the 7-nitro group to the 4-amino derivative. This derivative can be acetylated, hydroxylated, and glucuronidated.

Route of elimination

Clonazepam is highly metabolized, with less than 2% unchanged clonazepam being excreted in the urine. Metabolites of Klonopin are excreted by the kidneys. Clonazepam also undergoes acetylation via NAT2.

Toxicity

Somnolence, confusion, coma, and diminished reflexes. The most commonly reported adverse event when clonazepam is used for seizure disorders is CNS depression. LD50, oral, rats = >15000 mg/kg.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Cimetidine	Cimetidine may increase the effect of the benzodiazepine, clonazepam.
Clozapine	Increased risk of toxicity
Fluconazole	Fluconazole may increase the effect of the benzodiazepine, clonazepam.
Indinavir	The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, clonazepam.
Itraconazole	Itraconazole may increase the effect of the benzodiazepine, clonazepam.
Kava	Kava may increase the effect of the benzodiazepine, clonazepam.
Ketoconazole	Ketoconazole may increase the effect of the benzodiazepine, clonazepam.
Nelfinavir	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, clonazepam.
Omeprazole	Omeprazole may increase the effect of the benzodiazepine, clonazepam.
Ritonavir	The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, clonazepam.
Saquinavir	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, clonazepam.
St. John's Wort	St. John's Wort may decrease the effect of the benzodiazepine, clonazepam.
Telithromycin	Telithromycin may reduce clearance of Clonazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Clonazepam if Telithromycin is initiated, discontinued or dose changed.
Tipranavir	Tipranavir may decrease the metabolism and clearance of Clonazepam. Consider alternate therapy or monitor for Clonazepam toxic effects if Tipranavir is initiated or dose increased.
Triprolidine	The CNS depressants, Triprolidine and Clonazepam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Vigabatrin	Vigabatrin increases Cmax of clonazepam by 30% and decreases Tmax by 45%
Voriconazole	Voriconazole may increase the serum concentration of clonazepam by decreasing its metabolism. Monitor for clonazepam toxicity if voriconazole is initiated or dose increased.

Food Interactions

Take without regard to meals.
Avoid excessive quantities of coffee or tea (Caffeine).
Avoid alcohol.

Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.2274
Gamma-aminobutyric-acid receptor subunit alpha-2
Name	Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name	GABRA2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.1397
Gamma-aminobutyric-acid receptor subunit alpha-3
Name	Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name	GABRA3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.1361
Gamma-aminobutyric-acid receptor subunit alpha-4
Name	Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name	GABRA4
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.7777
Gamma-aminobutyric-acid receptor subunit alpha-5
Name	Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name	GABRA5
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.1622
Gamma-aminobutyric-acid receptor subunit beta-1
Name	Gamma-aminobutyric-acid receptor subunit beta-1
Gene Name	GABRB1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0743
Gamma-aminobutyric-acid receptor subunit beta-2
Name	Gamma-aminobutyric-acid receptor subunit beta-2
Gene Name	GABRB2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0557
Gamma-aminobutyric-acid receptor subunit beta-3
Name	Gamma-aminobutyric-acid receptor subunit beta-3
Gene Name	GABRB3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0707
Gamma-aminobutyric acid receptor subunit gamma-1
Name	Gamma-aminobutyric acid receptor subunit gamma-1
Gene Name	GABRG1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0672
Gamma-aminobutyric acid receptor subunit gamma-2
Name	Gamma-aminobutyric acid receptor subunit gamma-2
Gene Name	GABRG2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0887
Gamma-aminobutyric acid receptor subunit gamma-3
Name	Gamma-aminobutyric acid receptor subunit gamma-3
Gene Name	GABRG3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0383
Gamma-aminobutyric acid receptor subunit delta
Name	Gamma-aminobutyric acid receptor subunit delta
Gene Name	GABRD
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.056
Gamma-aminobutyric acid receptor subunit epsilon
Name	Gamma-aminobutyric acid receptor subunit epsilon
Gene Name	GABRE
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0542
Gamma-aminobutyric acid receptor subunit pi
Name	Gamma-aminobutyric acid receptor subunit pi
Gene Name	GABRP
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0292
Gamma-aminobutyric-acid receptor subunit rho-1
Name	Gamma-aminobutyric-acid receptor subunit rho-1
Gene Name	GABRR1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0345
Gamma-aminobutyric acid receptor subunit rho-2
Name	Gamma-aminobutyric acid receptor subunit rho-2
Gene Name	GABRR2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0401
Gamma-aminobutyric acid receptor subunit rho-3
Name	Gamma-aminobutyric acid receptor subunit rho-3
Gene Name	GABRR3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0371
Gamma-aminobutyric acid receptor subunit theta
Name	Gamma-aminobutyric acid receptor subunit theta
Gene Name	GABRQ
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.6889
Translocator protein
Name	Translocator protein
Gene Name	TSPO
Pharmacological action	unknown
Actions	other/unknown
References	Carmel I, Fares FA, Leschiner S, Scherubl H, Weisinger G, Gavish M: Peripheral-type benzodiazepine receptors in the regulation of proliferation of MCF-7 human breast carcinoma cell line. Biochem Pharmacol. 1999 Jul 15;58(2):273-8. - Pubmed Bono F, Lamarche I, Prabonnaud V, Le Fur G, Herbert JM: Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities. Biochem Biophys Res Commun. 1999 Nov 19;265(2):457-61. - Pubmed Bolger GT, Abraham S, Oz N, Weissman BA: Interactions between peripheral-type benzodiazepine receptor ligands and an activator of voltage-operated calcium channels. Can J Physiol Pharmacol. 1990 Jan;68(1):40-5. - Pubmed Marano G, Massotti M, Spagnolo A, Carpi A: Enhancement of pharmacologically induced bronchoconstriction by Ro 5-4864. Eur J Pharmacol. 1990 Apr 10;179(1-2):237-40. - Pubmed Awad M, Gavish M: Solubilization of peripheral-type benzodiazepine binding sites from cat cerebral cortex. J Neurochem. 1989 Jun;52(6):1880-5. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6147

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7852
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Tassaneeyakul W, Birkett DJ, Miners JO: Inhibition of human hepatic cytochrome P4502E1 by azole antifungals, CNS-active drugs and non-steroidal anti-inflammatory agents. Xenobiotica. 1998 Mar;28(3):293-301. - Pubmed
DTHybrid score	0.4193
Arylamine N-acetyltransferase 2
Name	Arylamine N-acetyltransferase 2
Gene Name	NAT2
Actions	substrate
References	Olivera M, Martinez C, Gervasini G, Carrillo JA, Ramos S, Benitez J, Garcia-Martin E, Agundez JA: Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam. Drug Metab Lett. 2007 Jan;1(1):3-5. - Pubmed Miller ME, Garland WA, Min BH, Ludwick BT, Ballard RH, Levy RH: Clonazepam acetylation in fast and slow acetylators. Clin Pharmacol Ther. 1981 Sep;30(3):343-7. - Pubmed
DTHybrid score	0.1764

Id	Partner name	Gene Name	Score
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.7245
6016	Cytochrome P450 2C19	CYP2C19	0.3255
4757	Cytochrome P450 2C9	CYP2C9	0.3181
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.2291
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.2289
1588	Multidrug resistance protein 1	ABCB1	0.2266
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.223
4924	Cytochrome P450 2C8	CYP2C8	0.2196
6030	Cytochrome P450 2B6	CYP2B6	0.2112
4118	Cytochrome P450 3A5	CYP3A5	0.2078
921	Glutamate receptor 2	GRIA2	0.1993
4200	Cytochrome P450 1A2	CYP1A2	0.1921
6107	Cytochrome P450 3A7	CYP3A7	0.1899
4119	Cytochrome P450 2D6	CYP2D6	0.1761
5718	Cytochrome P450 2A6	CYP2A6	0.1281
20	Prostaglandin G/H synthase 1	PTGS1	0.1251
6106	Cytochrome P450 2C18	CYP2C18	0.1225
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0848
6024	Cytochrome P450 1A1	CYP1A1	0.0674
482	Glycine receptor subunit alpha-1	GLRA1	0.056
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0549
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0546
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.052
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0513
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0503
6031	Cytochrome P450 3A43	CYP3A43	0.0459
290	Prostaglandin G/H synthase 2	PTGS2	0.0448
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0443
891	Dihydropteroate synthase	folP	0.0433
5359	Dihydropteroate synthase	folP	0.0433
7175	Dihydropteroate synthase	sulI	0.0433
1729	Solute carrier family 22 member 6	SLC22A6	0.0417
6145	Solute carrier family 22 member 1	SLC22A1	0.041
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.0399
6144	Solute carrier family 22 member 2	SLC22A2	0.037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0368
461	Glycine receptor subunit alpha-3	GLRA3	0.0352
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.035
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0347
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.032
820	Glycine receptor subunit alpha-2	GLRA2	0.0298
862	Multidrug resistance-associated protein 1	ABCC1	0.0297
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0292
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0292
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0287
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0283
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0278
3811	Cytochrome P450 19A1	CYP19A1	0.0278
705	Glutamate receptor 1	GRIA1	0.0268
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0265
518	Peroxidase/catalase T	katG	0.0264
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0264
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0256
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.025
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0245
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0238
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0237
556	Alpha-1A adrenergic receptor	ADRA1A	0.0235
1898	Cytochrome P450 1B1	CYP1B1	0.0235
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0234
3937	Fatty-acid amide hydrolase	FAAH	0.0227
3601	Dihydropteroate synthase 1	folP1	0.022
3807	Dihydropteroate synthase 1	folP1	0.022
3808	Dihydropteroate synthase 2	folP2	0.022
6020	Aldehyde oxidase	AOX1	0.0219
492	Histamine H1 receptor	HRH1	0.0217
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0217
23	D(1A) dopamine receptor	DRD1	0.0208
3426	Glutamine synthetase	glnA	0.0207
3987	Glutamine synthetase	GLUL	0.0207
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0201
2981	Phospholipase A2, membrane associated	PLA2G2A	0.02
6142	Solute carrier family 22 member 8	SLC22A8	0.0198
831	D(2) dopamine receptor	DRD2	0.0198
824	Sodium-dependent serotonin transporter	SLC6A4	0.0197
871	Glucocorticoid receptor	NR3C1	0.0182
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0177
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0177
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0177
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0177
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0171
1389	Transforming growth factor beta-1	TGFB1	0.0169
318	Alpha-2A adrenergic receptor	ADRA2A	0.0167
136	Estrogen receptor	ESR1	0.0165
776	Bile salt export pump	ABCB11	0.0164
468	Cytochrome P450 4A11	CYP4A11	0.0163
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0162
1024	Solute carrier family 22 member 11	SLC22A11	0.0159
260	Cytochrome P450 51	ERG11	0.0158
761	Cytochrome P450 51	ERG11	0.0158
3163	Cytochrome P450 51	cyp51	0.0158
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0154
172	Potassium channel subfamily K member 1	KCNK1	0.0154
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0153
2164	Multidrug resistance-associated protein 4	ABCC4	0.0152
738	Monocarboxylate transporter 1	SLC16A1	0.0152
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0151
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
1050	Bile salt sulfotransferase	SULT2A1	0.0149
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
1192	Sulfotransferase 1A1	SULT1A1	0.0137
6143	Solute carrier family 22 member 7	SLC22A7	0.0136
1757	Myeloperoxidase	MPO	0.0133
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0133
62	Glycine receptor subunit beta	GLRB	0.0132
489	Monocarboxylate transporter 2	SLC16A7	0.0128
632	Alpha-1B adrenergic receptor	ADRA1B	0.0127
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0123
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
617	Muscarinic acetylcholine receptor M2	CHRM2	0.012
1275	Estrogen sulfotransferase	SULT1E1	0.012
847	Mu-type opioid receptor	OPRM1	0.0118
500	Monocarboxylate transporter 4	SLC16A3	0.0118
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0117
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0113
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0112
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0111
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.011
118	Organic cation/carnitine transporter 2	SLC22A5	0.0106
465	Calmodulin	CALM1	0.0104
731	HIV-1 protease	HIV-1 protease	0.0103
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0098
2211	Fatty acid-binding protein, heart	FABP3	0.0098
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0096
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0095
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0095
566	Serotransferrin	TF	0.0094
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0094
629	Alpha-2B adrenergic receptor	ADRA2B	0.0094
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0092
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0092
3923	Cholinesterase	BCHE	0.0091
4604	Liver carboxylesterase 1	CES1	0.009
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0089
756	Sex hormone-binding globulin	SHBG	0.0089
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0088
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0088
467	Delta-type opioid receptor	OPRD1	0.0087
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0087
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0086
789	Alpha-1D adrenergic receptor	ADRA1D	0.0086
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0086
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0084
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0084
16	Adenosine A1 receptor	ADORA1	0.0082
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
592	Carbonic anhydrase 4	CA4	0.0082
696	Kappa-type opioid receptor	OPRK1	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
2178	Metabotropic glutamate receptor 5	GRM5	0.0078
614	Progesterone receptor	PGR	0.0077
122	P2Y purinoceptor 12	P2RY12	0.0077
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0077
6147	Solute carrier family 22 member 3	SLC22A3	0.0076
373	Transthyretin	TTR	0.0076
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0074
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0074
613	Atrial natriuretic peptide receptor A	NPR1	0.0074
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0072
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0072
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0072
3941	Amine oxidase [flavin-containing] A	MAOA	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0071
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0071
183	Vascular endothelial growth factor A	VEGFA	0.007
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.007
357	Carbonic anhydrase 2	CA2	0.007
6141	Sodium/bile acid cotransporter	SLC10A1	0.007
638	D(3) dopamine receptor	DRD3	0.007
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0069
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0069
3932	Glutathione S-transferase A2	GSTA2	0.0068
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0067
36	Insulin receptor	INSR	0.0066
378	Alpha-2C adrenergic receptor	ADRA2C	0.0066
713	Sodium-dependent dopamine transporter	SLC6A3	0.0065
844	Epidermal growth factor receptor	EGFR	0.0064
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0064
777	Tumor necrosis factor	TNF	0.0064
251	Alcohol dehydrogenase 1A	ADH1A	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
444	Alcohol dehydrogenase 1B	ADH1B	0.0063
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0063
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0062
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0062
833	Organic cation/carnitine transporter 1	SLC22A4	0.0062
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0062
817	DNA topoisomerase 2-alpha	TOP2A	0.0062
146	Androgen receptor	AR	0.006
1178	Adenosine A2a receptor	ADORA2A	0.006
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0059
70	Type-1 angiotensin II receptor	AGTR1	0.0059
818	50S ribosomal protein L10	rplJ	0.0058
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0058
766	Beta-2 adrenergic receptor	ADRB2	0.0058
869	Estrogen receptor beta	ESR2	0.0056
6085	Fatty acid-binding protein, intestinal	FABP2	0.0055
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0055
6043	Putative G-protein coupled receptor 44	GPR44	0.0055
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0055
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0055
29	Tubulin beta-1 chain	TUBB1	0.0054
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0054
3947	Xanthine dehydrogenase/oxidase	XDH	0.0054
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0053
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0053
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
432	D(4) dopamine receptor	DRD4	0.0051
6148	Multidrug resistance-associated protein 7	ABCC10	0.0051
3939	Amine oxidase [flavin-containing] B	MAOB	0.005
1010	Cytochrome P450 51A1	CYP51A1	0.005
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.005
436	5-hydroxytryptamine 2B receptor	HTR2B	0.005
6014	Cytochrome P450 2A13	CYP2A13	0.0049
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
193	Beta-1 adrenergic receptor	ADRB1	0.0049
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0048
517	Alcohol dehydrogenase 1C	ADH1C	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
161	Tubulin beta chain	TUBB	0.0048
312	Tubulin beta chain	TUB2	0.0048
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0048
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0047
6220	Aryl hydrocarbon receptor	AHR	0.0047
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
3382	Glycolipid transfer protein	GLTP	0.0046
4122	Histone deacetylase 2	HDAC2	0.0046
6136	Multidrug resistance-associated protein 5	ABCC5	0.0046
2230	Catalase	CAT	0.0045
3249	Catalase	katA	0.0045
3625	Catalase	katA	0.0045
4539	Catalase	katA	0.0045
4941	Catalase	katB	0.0045
295	Carbonic anhydrase 1	CA1	0.0045
716	5-hydroxytryptamine 7 receptor	HTR7	0.0045
814	Ryanodine receptor 1	RYR1	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
768	FK506-binding protein 1A	FKBP1A	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
4116	Dihydropteroate synthetase	Not Available	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0041
904	Glutathione S-transferase P	GSTP1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
558	Solute carrier family 12 member 1	SLC12A1	0.004
952	Dipeptidyl peptidase 4	DPP4	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
65	Matrix metalloproteinase-9	Not Available	0.004
4161	Furin	FURIN	0.004
94	5-hydroxytryptamine 4 receptor	HTR4	0.004
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0039
380	Cytochrome P450 17A1	CYP17A1	0.0039
459	Retinoic acid receptor RXR-alpha	RXRA	0.0039
6137	Multidrug resistance-associated protein 6	ABCC6	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0038
1483	Membrane copper amine oxidase	AOC3	0.0038
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0038
153	Dopamine beta-hydroxylase	DBH	0.0037
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0037
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0037
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0037
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
6126	Carbonic anhydrase 7	CA7	0.0036
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0036
6182	Cytochrome P450 2J2	CYP2J2	0.0036
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0036
594	Thyroxine-binding globulin	SERPINA7	0.0036
1268	Neuropeptide S receptor	NPSR1	0.0036
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0036
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
3404	Exotoxin A	eta	0.0036
856	Vitamin D3 receptor	VDR	0.0035
284	DNA-directed RNA polymerase beta chain	rpoB	0.0035
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0035
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0035
1656	CYP2B protein	CYP2B	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0034
6138	Multidrug resistance protein 3	ABCB4	0.0034
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0034
2207	Rhodopsin	RHO	0.0034
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0033
474	Acetylcholinesterase	ACHE	0.0033
758	Thyroid hormone receptor alpha	THRA	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
3810	Catechol O-methyltransferase	COMT	0.0033
6432	Transporter	snf	0.0032
6677	Myelin P2 protein	PMP2	0.0032
1867	Major prion protein	PRNP	0.0032
6073	Potassium channel subfamily K member 9	KCNK9	0.0032
6072	Potassium channel subfamily K member 3	KCNK3	0.0032
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0032
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
6766	O-GlcNAcase BT_4395	BT_4395	0.0031
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
365	Dihydrofolate reductase	DHFR	0.0031
2381	Dihydrofolate reductase	DFR1	0.0031
2833	Dihydrofolate reductase	Not Available	0.0031
2931	Dihydrofolate reductase	folA	0.0031
3544	Dihydrofolate reductase	folA	0.0031
3682	Dihydrofolate reductase	folA	0.0031
6642	Dihydrofolate reductase	folA	0.0031
6756	Dihydrofolate reductase	dfrA	0.0031
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
163	D(1B) dopamine receptor	DRD5	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.003
346	Thyroid hormone receptor beta-1	THRB	0.003
5787	Angiopoietin-1 receptor	TEK	0.003
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
780	Retinoic acid receptor RXR-gamma	RXRG	0.0029
504	Mast/stem cell growth factor receptor	KIT	0.0029
2290	ADP-ribosyl cyclase 2	BST1	0.0028
2298	Cytochrome P450-cam	camC	0.0028
233	Potassium channel subfamily K member 2	KCNK2	0.0028
1253	Interferon gamma	IFNG	0.0028
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
1517	Beta-3 adrenergic receptor	ADRB3	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1525	Heparin-binding growth factor 2	FGF2	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0028
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0027
88	Retinoic acid receptor RXR-beta	RXRB	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0027
4210	Toll-like receptor 4	TLR4	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
275	Arachidonate 5-lipoxygenase	ALOX5	0.0026
49	Endothelin B receptor	EDNRB	0.0026
1618	High affinity nerve growth factor receptor	NTRK1	0.0026
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
407	Vascular endothelial growth factor receptor 2	KDR	0.0025
563	Thyroid peroxidase	TPO	0.0025
6149	Solute carrier family 22 member 10	SLC22A10	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
358	Cystathionine beta-synthase	CBS	0.0025
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
1992	Vitamin D-binding protein	GC	0.0024
124	Histamine H2 receptor	HRH2	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
293	Gamma-glutamyl hydrolase	GGH	0.0023
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0023
1291	cAMP response element-binding protein	CREB1	0.0023
1353	DNA topoisomerase 1	TOP1	0.0023
3552	DNA topoisomerase 1	topA	0.0023
737	Mineralocorticoid receptor	NR3C2	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0022
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
823	Fibroblast growth factor receptor 2	FGFR2	0.0022
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
199	Monocarboxylate transporter 8	SLC16A2	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
707	72 kDa type IV collagenase	MMP2	0.0021
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0021
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0021
6459	Glycodelin	PAEP	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
244	Angiotensin-converting enzyme	ACE	0.0021
5934	Cytochrome P450 26A1	CYP26A1	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
1650	Heme carrier protein 1	SLC46A1	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
528	5-hydroxytryptamine 1E receptor	HTR1E	0.002
908	Glutathione S-transferase theta-1	GSTT1	0.002
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.002
3913	Glutamic acid decarboxylase	GAD65	0.0019
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0019
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0019
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0019
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0019
6131	Carbonic anhydrase 14	CA14	0.0019
3809	Estrogen-related receptor gamma	ESRRG	0.0019
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0019
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
4120	NADPH--cytochrome P450 reductase	POR	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
26	Vascular endothelial growth factor receptor 3	FLT4	0.0018
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
24	Thymidylate synthase	TMP1	0.0018
359	Thymidylate synthase	TYMS	0.0018
2626	Thymidylate synthase	thyA	0.0018
2729	Thymidylate synthase	thyA	0.0018
5352	Thymidylate synthase	THYA	0.0018
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0018
319	Opioid receptor, sigma 1	OPRS1	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
683	Potassium transporter	GK0582	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
162	Retinoic acid receptor gamma-1	RARG	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
239	Coagulation factor X	F10	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
32	Vascular endothelial growth factor receptor 1	FLT1	0.0017
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0017
976	Platelet glycoprotein IX	GP9	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0016
735	Alanine aminotransferase 1	GPT	0.0016
3904	Alanine aminotransferase 2	GPT2	0.0016
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0016
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
4217	Telomerase reverse transcriptase	TERT	0.0016
3233	Bile acid receptor	NR1H4	0.0015
54	Prothrombin	F2	0.0015
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0015
896	Glutathione S-transferase Mu 1	GSTM1	0.0015
174	Sigma 1-type opioid receptor	SIGMAR1	0.0015
427	Substance-P receptor	TACR1	0.0015
1629	Transcription factor AP-1	JUN	0.0015
4311	tRNA	TRDMT1	0.0015
4325	tRNA	trmD	0.0015
4328	tRNA	trmD	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
4192	DNA topoisomerase 2-beta	TOP2B	0.0015
7	Nitric oxide synthase, inducible	NOS2	0.0015
634	Squalene monooxygenase	SQLE	0.0014
7196	Squalene monooxygenase	ERG1	0.0014
1541	Metalloproteinase	mmp20	0.0014
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0014
268	Adenosine A2b receptor	ADORA2B	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
469	Annexin A1	ANXA1	0.0014
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0013
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0013
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0013
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0013
33	Cystine/glutamate transporter	SLC7A11	0.0013
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0013
6151	Monocarboxylate transporter 10	SLC16A10	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
6146	High affinity copper uptake protein 1	SLC31A1	0.0013
400	Coagulation factor IX	F9	0.0013
5461	Coagulation factor IX	F9	0.0013
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0013
273	Apoptosis regulator Bcl-2	BCL2	0.0013
84	Nuclear receptor 0B1	NR0B1	0.0013
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0013
2320	Thymidine kinase, cytosolic	TK1	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0012
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0012
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0012
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0012
822	Aldose reductase	AKR1B1	0.0012
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0012
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1864	RET proto-oncogene	RET	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0012
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0012
1295	Fatty acid synthase	FASN	0.0012
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0012
604	Vitamin K-dependent protein Z	PROZ	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
164	Histamine H4 receptor	HRH4	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0011
605	Fumarate reductase flavoprotein subunit	frdA	0.0011
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0011
3673	Fumarate reductase flavoprotein subunit	fccA	0.0011
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0011
6549	Fumarate reductase flavoprotein subunit	frdA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
751	Potassium channel subfamily K member 6	KCNK6	0.0011
3221	Cytochrome c4	cc4	0.0011
2236	Casein kinase II subunit alpha	CSNK2A1	0.0011
422	Vitamin K-dependent protein C	PROC	0.0011
1245	Vitamin K-dependent protein S	PROS1	0.0011
6218	Pannexin-1	PANX1	0.0011
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0011
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0011
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3007	Carbonic anhydrase 12	CA12	0.001
4205	Carbonic anhydrase 9	CA9	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
132	ATP-binding cassette sub-family A member 1	ABCA1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
2021	Thrombomodulin	THBD	0.001
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.001
6163	Copper-transporting ATPase 2	ATP7B	0.001
6165	Copper-transporting ATPase 1	ATP7A	0.001
3957	Adenosine deaminase	ADA	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
4773	Deoxycytidine kinase	DCK	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
165	FL cytokine receptor	FLT3	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
798	Osteocalcin	BGLAP	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
2132	Protein S100-B	S100B	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
291	Nitric-oxide synthase, endothelial	NOS3	0.0008
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0008
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0008
3639	Thymidine phosphorylase	deoA	0.0008
3936	Thymidine phosphorylase	TYMP	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
369	Coagulation factor VII	F7	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
6042	Prostaglandin reductase 2	PTGR2	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
5818	Folate receptor alpha	FOLR1	0.0007
2802	Endoglucanase G	celCCG	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
1792	Tissue-type plasminogen activator	PLAT	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
1313	Lactoylglutathione lyase	GLO1	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
5961	Insulin	INS	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
6755	Poliovirus receptor	PVR	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
4103	Proteasome subunit beta type 2	PSMB2	0.0004
4101	Proteasome subunit beta type 1	PSMB1	0.0004
4102	Proteasome subunit beta type 5	PSMB5	0.0004
1630	Integrin beta-2	ITGB2	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
4943	Cytochrome c6	petJ	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
5000	HemO	hemO	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4961	Hemophore HasA	hasA	0.0004
4909	CooA protein	cooA	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4972	P450cin	cinA	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4952	Catalase/peroxidase	katA	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
3093	Catalase HPII	katE	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
6044	Serum paraoxonase/lactonase 3	PON3	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
572	Integrin alpha-L	ITGAL	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0003
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
76	Nitric-oxide synthase, brain	NOS1	0.0003
4920	Peroxidase/catalase	katG	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
4990	PpcA	ppcA	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
6228	Nuclear receptor coactivator 1	NCOA1	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01068 - Clonazepam

Targets

Enzymes

Carriers

Predictions