DT-Web

DB00501 - Cimetidine


Identification
Name Cimetidine
Accession Number DB00501 (APRD00568)
Type small molecule
Description A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 252.339
Groups approved
Monoisotopic Weight 252.115715232
Pharmacology
Indication For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
Mechanism of action Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
Absorption Rapid 60-70%
Protein binding 15-20%
Biotransformation Hepatic
Route of elimination The principal route of excretion of cimetidine is the urine.
Toxicity Symptoms of overdose include nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Cimetidine may increase the anticoagulant effect of acenocoumarol.
Alfentanil Increases the effect of the narcotic
Alprazolam Cimetidine may increase the effect of the benzodiazepine, alprazolam.
Aminophylline Cimetidine may increase the serum concentration of aminophylline by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of aminophylline if cimetidine is initiated, discontinued or dose changed.
Amitriptyline Cimetidine may increase the effect of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if cimetidine is initiated, discontinued or dose changed.
Amoxapine Cimetidine may increase the effect of the tricyclic antidepressant, amoxapine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amoxapine if cimetidine is initiated, discontinued or dose changed.
Anisindione Cimetidine may increase the anticoagulant effect of anisindione.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
Bendamustine CA1A2 hepatic enzyme metabolism is affected by increased amounts of bendamustine by cimetidine. In addition, decreased conversion of bendamustine to active metabolites occurs. Amounts of active metabolites may be decreased. Decreased conversion of bendamustine to active metabolites also occurs.
Bromazepam Co-administration with cimetidine will cause a reduction in bromazepam clearance and increases half-life.
Carbamazepine Cimetidine may increase the serum concentration of carbamazepine during the first few days of concomitant therapy. Monitor for changes in the therapeutic and adverse effects of carbamazepine if cimetidine is initiated, discontinued or dose changed.
Carmustine Increases myelosuppression caused by carmustine
Cefditoren H2-Antagonists such as cimetidine may decrease the serum concentration of cefditoren. Cefditoren prescribing information recommends to avoid concomitant use with H2-antagonists (eg, famotidine, ranitidine) and antacids as well. Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of H2-antagonists can not be avoided.
Chlordiazepoxide Cimetidine may increase the effect of the benzodiazepine, chlordiazepoxide.
Clomipramine Cimetidine may increase the effect of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if cimetidine is initiated, discontinued or dose changed.
Clonazepam Cimetidine may increase the effect of the benzodiazepine, clonazepam.
Clorazepate Cimetidine may increase the effect of the benzodiazepine, clorazepate.
Clozapine Cimetidine may increase the serum concentratin of clozapine. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of clozapine if cimetidine is initiated, discontinued or dose changed.
Codeine Cimetidine may decrease the therapeutic effect of codeine by decreasing its metabolism to its active metabolite, morphine. Monitor for changes in the therapeutic effect of codeine if cimetidine is initiated, discontinued or dose changed.
Desipramine Cimetidine may increase the effect of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if cimetidine is initiated, discontinued or dose changed.
Diazepam Cimetidine may increase the effect of the benzodiazepine, diazepam.
Dicumarol Cimetidine may increase the anticoagulant effect of dicumarol.
Dihydroquinidine barbiturate Increases the effect of quinidine
Dofetilide Increases effect/toxicity of dofetilide
Donepezil Possible antagonism of action
Doxepin Cimetidine may increase the effect of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if cimetidine is initiated, discontinued or dose changed.
Dyphylline Increases the effect of theophylline
Eltrombopag Affects hepatic CYP1A2 metabolism, will decrease effect/level of eltrombopag. Affects hepatic CYP2C9/10 metabolism, will decrease effect/level of eltrombopag.
Enoxacin Cimetidine may decrease the absorption of enoxacin.
Epirubicin Cimetidine can increase epirubicin levels
Estazolam Cimetidine may increase the effect of the benzodiazepine, estazolam.
Ethotoin Increases the effect of hydantoin
Fentanyl Cimetidine, a moderate CYP3A4 inhibitor, may decrease the metabolism of fentanyl. Closely monitor changes in the therapeutic and adverse effects of fentanyl if cimetidine is initiated, discontinued or dose changed.
Flecainide Cimetidine, a moderate CYP2D6 inhibitor, may decrease the metabolism of flecainide.
Flurazepam Cimetidine may increase the effect of the benzodiazepine, flurazepam.
Fosphenytoin Cimetidine may increase the serum concentration of fosphenytoin by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of fosphenytoin if cimetidine is initiated, discontinued or dose changed.
Galantamine Possible antagonism of action
Halazepam Cimetidine may increase the effect of the benzodiazepine, halazepam.
Heroin Cimetidine increases the effect of the narcotic
Imipramine Cimetidine may increase the effect of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if cimetidine is initiated, discontinued or dose changed.
Itraconazole The H2-receptor antagonist, cimetidine, may decrease the absorption of itraconazole.
Ketazolam Cimetidine may increase the effect of the benzodiazepine, ketazolam.
Ketoconazole The H2-receptor antagonist, cimetidine, may decrease the absorption of ketoconazole.
Labetalol Cimetidine may increase the serum concentration of labetolol by decreasing its metabolism.
Lidocaine Increases the effect and toxicity of lidocaine
Mephenytoin Increases the effect of hydantoin
Metformin Cimetidine may increase the therapeutic and adverse effects of metformin by increasing its serum concentration. Consider alternate therapy.
Methadone Cimetidine, a moderate CYP3A4 inhibitor, may increase the serum concentration of metahdone, a CYP3A4 substrate. Monitor for changes in the therapeutic and adverse effects of methadone if cimetidine is initiatied, discontinued or dose changed.
Metoprolol Cimetidine may increase the serum concentration of metoprolol by decreasing its metabolism.
Midazolam Cimetidine may increase the effect of the benzodiazepine, midazolam.
Moclobemide Cimetidine may increase the serum concentration of moclobemide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of moclobemide if cimetidine is initiated, discontinued or dose changed.
Nalbuphine Increases the effect of the narcotic
Nifedipine Cimetidine may increase the effect of the calcium channel blocker, nifedipine.
Nimodipine Cimetidine increases the effect of the calcium channel blocker, nimodipine.
Nitrendipine Cimetidine increases the effect of the calcium channel blocker, nitrendipine.
Nortriptyline Cimetidine may increase the effect of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if cimetidine is initiated, discontinued or dose changed.
Oxtriphylline Cimetidine may increase the serum concentration of oxtriphylline by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of oxtriphylline if cimetidine is initiated, discontinued or dose changed.
Oxycodone Cimetidine, a moderate CYP3A4 inhibitor, may decrease the metabolism of oxycodone. Monitor for changes in the therapeutic and adverse effects of oxycodone if cimetidine is initiated, discontinued or dose changed.
Oxymorphone Increases the effect of the narcotic
Pazopanib Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Phenytoin Cimetidine may increase the therapeutic effect of phenytoin.
Posaconazole Significant decrease of posaconazole levels
Pramipexole Cimetidine may increase the effect and toxicity of pramipexole.
Prazepam Cimetidine may increase the effect of the benzodiazepine, prazepam.
Procainamide The histamine H2-receptor antagonist, cimetidine, may increase the effect of procainamide.
Propoxyphene Cimetidine, a moderate CYP3A4 inhibitor, may decrease the metabolism of propoxyphene. Monitor for changes in the therapeutic and adverse effects of propoxyphene if cimetidine is intitiated, discontinued or dose changed.
Propranolol Cimetidine may increase the serum concentration of propranolol by decreasing its metabolism.
Protriptyline Cimetidine may increase the effect of tricyclic antidepressant, protriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of trimipramine if cimetidine is initiated, discontinued or dose changed.
Quazepam Cimetidine may increase the effect of the benzodiazepine, quazepam.
Quinidine Cimetidine may increase the serum concentration of quinidine. Monitor for changes in the therapeutic and adverse effects of quinidine if cimetidine is initiated, discontinued or dose changed.
Quinidine barbiturate Increases the effect of quinidine
Rivastigmine Possible antagonism of action
Roflumilast Increases roflumilast levels.
Sildenafil Increases the effect and toxicity of sildenafil
Sufentanil Increases the effect of the narcotic
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by Cimetidine, a CYP1A2 inhibitors. Monitor the efficacy and toxicity of Tacrine if Cimetidine is initiated, discontinued or if the dose is changed.
Tacrolimus Cimetidine may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Cimetidine therapy is initiated, discontinued or altered.
Tamoxifen Cimetidine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Cimetidine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Cimetidine is initiated, discontinued, or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Theophylline Cimetidine may increase the effect of theophylline.
Ticlopidine Cimetidine may increase Ticlopidine levels. Avoid concomitant therapy.
Timolol Cimetidine may increase the serum concentration of timolol by decreasing its metabolism.
Tizanidine Cimetidine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Tolazoline Anticipated loss of efficacy of tolazoline
Tolterodine Cimetidine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tramadol Cimetidine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Cimetidine may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The CYP3A4 inhibitor, Cimetidine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Cimetidine is initiated, discontinued or dose changed.
Triazolam Cimetidine may increase the serum concentration of triazolam by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of triazolam if cimetidine is initiated, discontinued or dose changed.
Trimipramine Cimetidine may increase the effect of tricyclic antidepressant, trimipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of trimipramine if cimetidine is initiated, discontinued or dose changed.
Vilazodone Cimetidine may decrease the metabolism of Selective Serotonin Reuptake Inhibitors. Consider using an alternative H2-antagonist to avoid the risk of selective serotonin reuptake inhibitor (SSRI) toxicity. Monitor for increased therapeutic or toxic effects of SSRI if cimetidine is initiated/dose increased, or decreased effects if cimetidine is discontinued/dose decreased.
Warfarin Cimetidine may increase the serum concentration of warfarin. Monitor for changes in prothrombin time and therapeutic and adverse effects of warfarin if cimetidine is initiated, discontinued or dose changed.
Zaleplon Cimetidine may increase the serum concentration of zaleplon by decreasing its metabolism. Reduce the initial dose of zaleplon to 5 mg in patients receiving cimetidine.
Food Interactions
  • Best effect when taken with food.
  • Limit caffeine intake.
  • Avoid alcohol.

Targets


Histamine H2 receptor
Name Histamine H2 receptor
Gene Name HRH2
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Hernandez-Munoz R, Montiel-Ruiz C, Vazquez-Martinez O: Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats. Lab Invest. 2000 Aug;80(8):1161-9. - Pubmed
  • Kuint J, Linder N, Reichman B: Hypoxemia associated with cimetidine therapy in a newborn infant. Am J Perinatol. 1996 Jul;13(5):301-3. - Pubmed
  • Takahashi HK, Watanabe T, Yokoyama A, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. Epub 2006 May 24. - Pubmed
DTHybrid score 0.6322

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7295
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
DTHybrid score 0.7518
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y: Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther. 2002 Aug;302(2):510-5. - Pubmed
  • Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y: Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther. 2002 Aug;302(2):510-5. - Pubmed
DTHybrid score 1.2309
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6746
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5413
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
DTHybrid score 0.8708
Cytochrome P450 11B1, mitochondrial
Name Cytochrome P450 11B1, mitochondrial
Gene Name CYP11B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2304
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5992
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8196
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4595
Dimethylaniline monooxygenase [N-oxide-forming] 3
Name Dimethylaniline monooxygenase [N-oxide-forming] 3
Gene Name FMO3
Actions substrate
References
  • Cashman JR: Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism. Curr Drug Metab. 2000 Sep;1(2):181-91. - Pubmed
  • Cashman JR, Park SB, Berkman CE, Cashman LE: Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans. Chem Biol Interact. 1995 Apr 28;96(1):33-46. - Pubmed
  • Hai X, Adams E, Hoogmartens J, Van Schepdael A: Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms. Electrophoresis. 2009 Apr;30(7):1248-57. - Pubmed
DTHybrid score 0.2057
Dimethylaniline monooxygenase [N-oxide-forming] 1
Name Dimethylaniline monooxygenase [N-oxide-forming] 1
Gene Name FMO1
Actions substrate
References
  • Hai X, Adams E, Hoogmartens J, Van Schepdael A: Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms. Electrophoresis. 2009 Apr;30(7):1248-57. - Pubmed
  • Cashman JR: Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism. Curr Drug Metab. 2000 Sep;1(2):181-91. - Pubmed
DTHybrid score 0.2662

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor,inducer
References
  • Romiti N, Tramonti G, Chieli E: Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91. - Pubmed
  • Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE: Influence of passive permeability on apparent P-glycoprotein kinetics. Pharm Res. 2000 Dec;17(12):1456-60. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • van der Sandt IC, Blom-Roosemalen MC, de Boer AG, Breimer DD: Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. Eur J Pharm Sci. 2000 Sep;11(3):207-14. - Pubmed
  • Ito T, Yano I, Tanaka K, Inui KI: Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997 Aug;282(2):955-60. - Pubmed
  • Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed
DTHybrid score 0.8092
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate,inhibitor
References
  • Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed
  • Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. - Pubmed
  • Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. - Pubmed
  • Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. - Pubmed
  • Okuda M, Urakami Y, Saito H, Inui K: Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. - Pubmed
  • Pan BF, Sweet DH, Pritchard JB, Chen R, Nelson JA: A transfected cell model for the renal toxin transporter, rOCT2. Toxicol Sci. 1999 Feb;47(2):181-6. - Pubmed
  • Dudley AJ, Bleasby K, Brown CD: The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Grundemann, D., Liebich, G., Kiefer, N., Koster, S. & Schomig, E. Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol 56, 1-10 (1999). - Pubmed
DTHybrid score 0.4773
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate,inhibitor
References
  • Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed
  • Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed
  • Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. - Pubmed
  • Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM: Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). J Biol Chem. 1997 Jun 27;272(26):16548-54. - Pubmed
  • Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. - Pubmed
  • Okuda M, Urakami Y, Saito H, Inui K: Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. - Pubmed
  • Jonker JW, Wagenaar E, Mol CA, Buitelaar M, Koepsell H, Smit JW, Schinkel AH: Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol Cell Biol. 2001 Aug;21(16):5471-7. - Pubmed
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
  • Wang, D.S. et al. Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther 302, 510-515 (2002). - Pubmed
DTHybrid score 0.5559
Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions substrate,inhibitor
References
  • Grundemann D, Schechinger B, Rappold GA, Schomig E: Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci. 1998 Sep;1(5):349-51. - Pubmed
  • Wu X, Huang W, Ganapathy ME, Wang H, Kekuda R, Conway SJ, Leibach FH, Ganapathy V: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. - Pubmed
  • Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V: Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 1998 Jun 26;273(26):15971-9. - Pubmed
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
DTHybrid score 0.3415
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. - Pubmed
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
  • Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score 0.4756
Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed
DTHybrid score 0.2645
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions substrate,inhibitor
References
  • Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed
  • Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed
  • Nagata Y, Kusuhara H, Endou H, Sugiyama Y: Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol. 2002 May;61(5):982-8. - Pubmed
  • Burckhardt BC, Brai S, Wallis S, Krick W, Wolff NA, Burckhardt G: Transport of cimetidine by flounder and human renal organic anion transporter 1. Am J Physiol Renal Physiol. 2003 Mar;284(3):F503-9. Epub 2002 Nov 12. - Pubmed
DTHybrid score 0.6554
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions substrate,inhibitor
References
  • Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed
  • Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed
  • Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. - Pubmed
  • Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed
  • Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed
  • Nagata Y, Kusuhara H, Endou H, Sugiyama Y: Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol. 2002 May;61(5):982-8. - Pubmed
  • Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40. - Pubmed
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
  • Bakhiya A, Bahn A, Burckhardt G, Wolff N: Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Physiol Biochem. 2003;13(5):249-56. - Pubmed
  • Tahara H, Kusuhara H, Chida M, Fuse E, Sugiyama Y: Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther. 2006 Mar;316(3):1187-94. Epub 2005 Nov 16. - Pubmed
  • Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score 0.568
Multidrug and toxin extrusion protein 1
Name Multidrug and toxin extrusion protein 1
Gene Name SLC47A1
Actions inhibitor
References
  • Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, Kumar V, Stevens JC: Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44. Epub 2010 Jun 2. - Pubmed
DTHybrid score 0.3009
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
  • Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):315-27. - Pubmed
DTHybrid score 0.3256
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed
DTHybrid score 0.3663
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions substrate,inhibitor
References
  • Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. - Pubmed
  • Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score 0.3347

Predictions


Id Partner name Gene Name Score
6030 Cytochrome P450 2B6 CYP2B6 0.3446
6024 Cytochrome P450 1A1 CYP1A1 0.2897
587 Serum albumin ALB 0.2895
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.2647
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.2469
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.2409
5718 Cytochrome P450 2A6 CYP2A6 0.2403
20 Prostaglandin G/H synthase 1 PTGS1 0.2183
862 Multidrug resistance-associated protein 1 ABCC1 0.2108
492 Histamine H1 receptor HRH1 0.2003
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1966
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1556
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1431
290 Prostaglandin G/H synthase 2 PTGS2 0.1377
6106 Cytochrome P450 2C18 CYP2C18 0.1316
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1289
2164 Multidrug resistance-associated protein 4 ABCC4 0.1276
1898 Cytochrome P450 1B1 CYP1B1 0.1206
556 Alpha-1A adrenergic receptor ADRA1A 0.1198
51 Muscarinic acetylcholine receptor M3 CHRM3 0.1148
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.1147
3811 Cytochrome P450 19A1 CYP19A1 0.1131
831 D(2) dopamine receptor DRD2 0.113
824 Sodium-dependent serotonin transporter SLC6A4 0.1129
502 5-hydroxytryptamine 2A receptor HTR2A 0.1099
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.106
260 Cytochrome P450 51 ERG11 0.1034
761 Cytochrome P450 51 ERG11 0.1034
3163 Cytochrome P450 51 cyp51 0.1034
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1029
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0995
318 Alpha-2A adrenergic receptor ADRA2A 0.0993
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0991
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0977
6141 Sodium/bile acid cotransporter SLC10A1 0.0912
766 Beta-2 adrenergic receptor ADRB2 0.09
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0889
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0878
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0875
629 Alpha-2B adrenergic receptor ADRA2B 0.085
3923 Cholinesterase BCHE 0.0802
378 Alpha-2C adrenergic receptor ADRA2C 0.0779
320 5-hydroxytryptamine 1A receptor HTR1A 0.0775
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0774
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0771
193 Beta-1 adrenergic receptor ADRB1 0.0768
590 5-hydroxytryptamine 2C receptor HTR2C 0.0759
632 Alpha-1B adrenergic receptor ADRA1B 0.0755
23 D(1A) dopamine receptor DRD1 0.0749
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0747
3941 Amine oxidase [flavin-containing] A MAOA 0.0745
817 DNA topoisomerase 2-alpha TOP2A 0.0727
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0726
136 Estrogen receptor ESR1 0.0711
404 DNA gyrase subunit A gyrA 0.0706
6224 DNA gyrase subunit A gyrA 0.0706
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0703
713 Sodium-dependent dopamine transporter SLC6A3 0.0694
6148 Multidrug resistance-associated protein 7 ABCC10 0.069
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0675
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.067
738 Monocarboxylate transporter 1 SLC16A1 0.0669
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0665
6031 Cytochrome P450 3A43 CYP3A43 0.0655
477 DNA topoisomerase 4 subunit A parC 0.064
886 DNA topoisomerase 4 subunit A parC 0.064
6226 DNA topoisomerase 4 subunit A parC 0.064
341 5-hydroxytryptamine 3 receptor HTR3A 0.0639
756 Sex hormone-binding globulin SHBG 0.0635
6136 Multidrug resistance-associated protein 5 ABCC5 0.0634
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0611
380 Cytochrome P450 17A1 CYP17A1 0.06
338 DNA polymerase UL30 0.0598
379 DNA polymerase UL54 0.0598
697 DNA polymerase ORF28 0.0598
2482 DNA polymerase 43 0.0598
4104 DNA polymerase BALF5 0.0598
847 Mu-type opioid receptor OPRM1 0.0593
885 5-hydroxytryptamine 1B receptor HTR1B 0.0587
844 Epidermal growth factor receptor EGFR 0.0579
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0555
737 Mineralocorticoid receptor NR3C2 0.0553
183 Vascular endothelial growth factor A VEGFA 0.0551
638 D(3) dopamine receptor DRD3 0.0547
789 Alpha-1D adrenergic receptor ADRA1D 0.0541
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0541
871 Glucocorticoid receptor NR3C1 0.0538
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0531
3939 Amine oxidase [flavin-containing] B MAOB 0.0516
4604 Liver carboxylesterase 1 CES1 0.0515
731 HIV-1 protease HIV-1 protease 0.0491
3947 Xanthine dehydrogenase/oxidase XDH 0.0478
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0477
725 5-hydroxytryptamine 1D receptor HTR1D 0.0476
22 30S ribosomal protein S4 rpsD 0.047
6714 30S ribosomal protein S4 rpsD 0.047
140 30S ribosomal protein S9 rpsI 0.0466
6719 30S ribosomal protein S9 rpsI 0.0466
6725 30S ribosomal protein S9 rpsI 0.0466
6137 Multidrug resistance-associated protein 6 ABCC6 0.0464
467 Delta-type opioid receptor OPRD1 0.046
5787 Angiopoietin-1 receptor TEK 0.0457
465 Calmodulin CALM1 0.0451
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0451
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.045
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0444
633 Penicillin-binding proteins 1A/1B pbpA 0.044
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.044
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0435
696 Kappa-type opioid receptor OPRK1 0.0431
1757 Myeloperoxidase MPO 0.043
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0419
432 D(4) dopamine receptor DRD4 0.0416
146 Androgen receptor AR 0.0416
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0413
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0411
4148 Serine/threonine-protein kinase mTOR MTOR 0.0404
468 Cytochrome P450 4A11 CYP4A11 0.04
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0394
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0393
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0388
474 Acetylcholinesterase ACHE 0.0384
131 Synaptic vesicular amine transporter SLC18A2 0.0374
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.037
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.037
716 5-hydroxytryptamine 7 receptor HTR7 0.037
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0369
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0369
269 Adrenodoxin, mitochondrial FDX1 0.0358
232 Corticosteroid-binding globulin SERPINA6 0.0354
869 Estrogen receptor beta ESR2 0.0353
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0349
645 Penicillin-binding protein 1A mrcA 0.0347
5805 Penicillin-binding protein 1A ponA 0.0347
6185 Penicillin-binding protein 1A mrcA 0.0347
6799 Penicillin-binding protein 1A pbpA 0.0347
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0344
164 Histamine H4 receptor HRH4 0.0343
161 Tubulin beta chain TUBB 0.0342
312 Tubulin beta chain TUB2 0.0342
94 5-hydroxytryptamine 4 receptor HTR4 0.0337
4203 Histamine N-methyltransferase HNMT 0.0337
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0336
504 Mast/stem cell growth factor receptor KIT 0.0333
6182 Cytochrome P450 2J2 CYP2J2 0.0333
6014 Cytochrome P450 2A13 CYP2A13 0.0324
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0324
2472 Voltage-gated potassium channel kcsA 0.0322
6366 Voltage-gated potassium channel kcsA 0.0322
6020 Aldehyde oxidase AOX1 0.0321
614 Progesterone receptor PGR 0.0319
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0317
1192 Sulfotransferase 1A1 SULT1A1 0.0315
887 DNA gyrase subunit B gyrB 0.0306
4150 DNA gyrase subunit B gyrB 0.0306
6225 DNA gyrase subunit B gyrB 0.0306
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0298
436 5-hydroxytryptamine 2B receptor HTR2B 0.0297
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0296
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0296
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0295
1341 Histamine H3 receptor HRH3 0.0294
6149 Solute carrier family 22 member 10 SLC22A10 0.0293
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0293
6102 Arylamine N-acetyltransferase 2 NAT2 0.0292
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.029
5626 Nucleoside diphosphate kinase B NME2 0.0288
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0286
16 Adenosine A1 receptor ADORA1 0.0283
4773 Deoxycytidine kinase DCK 0.0279
558 Solute carrier family 12 member 1 SLC12A1 0.0278
357 Carbonic anhydrase 2 CA2 0.0275
592 Carbonic anhydrase 4 CA4 0.0275
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0274
543 Penicillin-binding protein 1B mrcB 0.0274
6186 Penicillin-binding protein 1B ponB 0.0274
6822 Penicillin-binding protein 1b pbp1b 0.0274
6844 Penicillin-binding protein 1b pbp1b 0.0274
295 Carbonic anhydrase 1 CA1 0.0274
672 Prostaglandin F2-alpha receptor PTGFR 0.0273
228 Beta platelet-derived growth factor receptor PDGFRB 0.0271
5353 Glutamate decarboxylase alpha gadA 0.027
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0269
163 D(1B) dopamine receptor DRD5 0.0268
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0267
7 Nitric oxide synthase, inducible NOS2 0.0265
1178 Adenosine A2a receptor ADORA2A 0.0265
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0264
1010 Cytochrome P450 51A1 CYP51A1 0.0263
768 FK506-binding protein 1A FKBP1A 0.0262
122 P2Y purinoceptor 12 P2RY12 0.0261
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0261
29 Tubulin beta-1 chain TUBB1 0.026
36 Insulin receptor INSR 0.0258
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0258
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0257
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0257
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0254
1256 5-hydroxytryptamine 6 receptor HTR6 0.0253
5126 Arginase rocF 0.025
438 Taste receptor type 1 member 2 TAS1R2 0.0248
6010 Thiamine transporter 1 SLC19A2 0.0248
624 Guanidinoacetate N-methyltransferase GAMT 0.0248
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0247
6167 Organic solute transporter subunit beta OSTB 0.0244
6166 Organic solute transporter subunit alpha OSTA 0.0244
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0242
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0241
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.024
1525 Heparin-binding growth factor 2 FGF2 0.0239
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0238
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0238
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0238
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0237
1 Peptidoglycan synthetase ftsI ftsI 0.0237
4155 Peptidoglycan synthetase ftsI ftsI 0.0237
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0236
811 Translocator protein TSPO 0.0235
527 Prostacyclin receptor PTGIR 0.0234
449 Ornithine decarboxylase ODC1 0.0233
5294 Nucleoside diphosphate kinase A NME1 0.0232
275 Arachidonate 5-lipoxygenase ALOX5 0.0231
777 Tumor necrosis factor TNF 0.0231
1636 Trace amine-associated receptor 1 TAAR1 0.0227
4122 Histone deacetylase 2 HDAC2 0.0225
723 Cytosolic phospholipase A2 PLA2G4A 0.0225
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0225
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0225
175 Thiamin pyrophosphokinase 1 TPK1 0.0222
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
4120 NADPH--cytochrome P450 reductase POR 0.0221
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0219
332 Beta-lactamase blaZ 0.0219
2478 Beta-lactamase ampC 0.0219
2613 Beta-lactamase ampC 0.0219
2635 Beta-lactamase ampC 0.0219
2700 Beta-lactamase penP 0.0219
5445 Beta-lactamase blaB 0.0219
6019 Beta-lactamase SHV-7 0.0219
6701 Beta-lactamase cphA 0.0219
818 50S ribosomal protein L10 rplJ 0.0218
373 Transthyretin TTR 0.0217
70 Type-1 angiotensin II receptor AGTR1 0.0217
1867 Major prion protein PRNP 0.0216
6432 Transporter snf 0.0213
891 Dihydropteroate synthase folP 0.0213
5359 Dihydropteroate synthase folP 0.0213
7175 Dihydropteroate synthase sulI 0.0213
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0212
3601 Dihydropteroate synthase 1 folP1 0.0212
3807 Dihydropteroate synthase 1 folP1 0.0212
3808 Dihydropteroate synthase 2 folP2 0.0212
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0211
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.021
3560 Gentamicin 3'-acetyltransferase aacC1 0.021
49 Endothelin B receptor EDNRB 0.0209
2429 Putrescine-binding periplasmic protein potF 0.0206
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0206
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0206
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0206
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0205
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0205
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0205
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0205
273 Apoptosis regulator Bcl-2 BCL2 0.0204
469 Annexin A1 ANXA1 0.0203
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
683 Potassium transporter GK0582 0.0203
976 Platelet glycoprotein IX GP9 0.0202
2808 Chloramphenicol acetyltransferase 3 cat3 0.0201
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0201
6220 Aryl hydrocarbon receptor AHR 0.0201
3810 Catechol O-methyltransferase COMT 0.02
407 Vascular endothelial growth factor receptor 2 KDR 0.02
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
2016 Dipeptidase 1 DPEP1 0.0197
578 Endothelin-1 receptor EDNRA 0.0197
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0196
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0196
6070 Nischarin NISCH 0.0196
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0195
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0195
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0195
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0195
6085 Fatty acid-binding protein, intestinal FABP2 0.0194
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0193
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0193
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
2539 Tubulin alpha-1 chain TUBA4A 0.019
950 Alpha platelet-derived growth factor receptor PDGFRA 0.019
528 5-hydroxytryptamine 1E receptor HTR1E 0.019
1517 Beta-3 adrenergic receptor ADRB3 0.0188
6126 Carbonic anhydrase 7 CA7 0.0187
6207 30S ribosomal protein S14 rpsN 0.0186
6209 30S ribosomal protein S19 rpsS 0.0186
6712 30S ribosomal protein S19 rpsS 0.0186
6726 30S ribosomal protein S19 rpsS 0.0186
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0183
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0182
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0181
952 Dipeptidyl peptidase 4 DPP4 0.018
244 Angiotensin-converting enzyme ACE 0.018
26 Vascular endothelial growth factor receptor 3 FLT4 0.018
6033 High affinity interleukin-8 receptor A CXCR1 0.0179
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0179
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0179
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0178
2300 Lysozyme E 0.0178
3633 Lysozyme R 0.0178
5597 Lysozyme 17 0.0178
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0177
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0177
365 Dihydrofolate reductase DHFR 0.0176
2381 Dihydrofolate reductase DFR1 0.0176
2833 Dihydrofolate reductase Not Available 0.0176
2931 Dihydrofolate reductase folA 0.0176
3544 Dihydrofolate reductase folA 0.0176
3682 Dihydrofolate reductase folA 0.0176
6642 Dihydrofolate reductase folA 0.0176
6756 Dihydrofolate reductase dfrA 0.0176
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0174
153 Dopamine beta-hydroxylase DBH 0.0174
150 Cationic amino acid transporter 3 SLC7A3 0.0173
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0173
58 Cationic amino acid transporter 4 SLC7A4 0.0173
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0173
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0173
32 Vascular endothelial growth factor receptor 1 FLT1 0.0171
2320 Thymidine kinase, cytosolic TK1 0.0171
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.017
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
24 Thymidylate synthase TMP1 0.0169
359 Thymidylate synthase TYMS 0.0169
2626 Thymidylate synthase thyA 0.0169
2729 Thymidylate synthase thyA 0.0169
5352 Thymidylate synthase THYA 0.0169
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0169
130 Prostacyclin synthase PTGIS 0.0168
2249 Aspartate aminotransferase aspC 0.0167
2671 Aspartate aminotransferase aspC 0.0167
5490 Aspartate aminotransferase Not Available 0.0167
65 Matrix metalloproteinase-9 Not Available 0.0166
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0166
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0166
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0165
342 P protein [Includes: DNA-directed DNA polymerase P 0.0165
612 P protein [Includes: DNA-directed DNA polymerase P 0.0165
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0163
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0163
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0161
4217 Telomerase reverse transcriptase TERT 0.0159
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0159
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0159
3639 Thymidine phosphorylase deoA 0.0157
3936 Thymidine phosphorylase TYMP 0.0157
828 Phenylalanine-4-hydroxylase PAH 0.0156
3109 Phenylalanine-4-hydroxylase phhA 0.0156
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0156
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0155
751 Potassium channel subfamily K member 6 KCNK6 0.0155
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0154
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0153
4237 50S ribosomal protein L22 rplV 0.0153
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0152
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0151
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
427 Substance-P receptor TACR1 0.0149
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0148
6138 Multidrug resistance protein 3 ABCB4 0.0147
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0146
1852 Microtubule-associated protein 2 MAP2 0.0146
4238 50S ribosomal protein L4 rplD 0.0146
5578 50S ribosomal protein L4 rplD 0.0146
6173 50S ribosomal protein L4 rplD 0.0146
6219 50S ribosomal protein L4 rplD 0.0146
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6151 Monocarboxylate transporter 10 SLC16A10 0.0144
1656 CYP2B protein CYP2B 0.0143
3917 Methylenetetrahydrofolate reductase MTHFR 0.0142
2298 Cytochrome P450-cam camC 0.0142
172 Potassium channel subfamily K member 1 KCNK1 0.0142
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0141
303 Diamine acetyltransferase 2 SAT2 0.0141
1629 Transcription factor AP-1 JUN 0.0141
1317 Spermine synthase SMS 0.0141
623 Spermine oxidase SMOX 0.0141
904 Glutathione S-transferase P GSTP1 0.0141
5682 Ribonuclease pancreatic RNASE1 0.0141
705 Glutamate receptor 1 GRIA1 0.0141
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0141
867 Penicillin-binding protein 3 pbpC 0.014
6119 Penicillin-binding protein 3 pbp3 0.014
7154 Penicillin-binding protein 3 pbp3 0.014
7157 Penicillin-binding protein 3 LMHCC_2184 0.014
7162 Penicillin-binding protein 3 pbpB 0.014
7172 Penicillin-binding protein 3 pbp3 0.014
6218 Pannexin-1 PANX1 0.0139
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0139
6146 High affinity copper uptake protein 1 SLC31A1 0.0139
571 Melatonin receptor type 1A MTNR1A 0.0138
362 Melatonin receptor type 1B MTNR1B 0.0138
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0138
1063 Signal transducer and activator of transcription 5B STAT5B 0.0138
1654 Interleukin-1 beta IL1B 0.0137
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0136
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0136
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0136
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0136
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0133
936 Ephrin type-A receptor 2 EPHA2 0.0132
5923 Microtubule-associated protein tau MAPT 0.0131
5924 Microtubule-associated protein 4 MAP4 0.0131
4116 Dihydropteroate synthetase Not Available 0.0131
2449 Tubulin alpha-3 chain TUBA1A 0.013
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0129
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0129
6043 Putative G-protein coupled receptor 44 GPR44 0.0129
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0128
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0128
823 Fibroblast growth factor receptor 2 FGFR2 0.0128
908 Glutathione S-transferase theta-1 GSTT1 0.0128
3685 Catabolite gene activator crp 0.0127
53 Solute carrier family 12 member 5 SLC12A5 0.0127
663 Solute carrier family 12 member 4 SLC12A4 0.0127
4655 Adenylate cyclase cyaC 0.0127
4759 Adenylate cyclase cyaB2 0.0127
1360 Sphingomyelin phosphodiesterase SMPD1 0.0127
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0127
482 Glycine receptor subunit alpha-1 GLRA1 0.0127
484 Tyrosine-protein kinase ABL2 ABL2 0.0127
123 Diamine acetyltransferase 1 SAT1 0.0127
33 Cystine/glutamate transporter SLC7A11 0.0126
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0126
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0126
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0126
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0126
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0126
6168 Solute carrier family 22 member 16 SLC22A16 0.0126
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0125
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0125
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0125
769 High-affinity choline transporter 1 SLC5A7 0.0125
3927 Choline transporter-like protein 3 SLC44A3 0.0125
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0125
1686 Choline transporter-like protein 1 SLC44A1 0.0125
3926 Choline transporter-like protein 2 SLC44A2 0.0125
861 Choline kinase alpha CHKA 0.0125
700 Choline dehydrogenase, mitochondrial CHDH 0.0125
3925 Choline transporter-like protein 4 SLC44A4 0.0125
576 Choline O-acetyltransferase CHAT 0.0125
3922 Phospholipase D2 PLD2 0.0125
3924 Phospholipase D1 PLD1 0.0125
165 FL cytokine receptor FLT3 0.0125
3426 Glutamine synthetase glnA 0.0123
3987 Glutamine synthetase GLUL 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
5934 Cytochrome P450 26A1 CYP26A1 0.0122
3809 Estrogen-related receptor gamma ESRRG 0.0122
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.012
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
310 Solute carrier family 12 member 2 SLC12A2 0.0119
1618 High affinity nerve growth factor receptor NTRK1 0.0119
3270 Elongation factor G fusA 0.0119
284 DNA-directed RNA polymerase beta chain rpoB 0.0118
5773 DNA-directed RNA polymerase beta chain rpoB 0.0118
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0118
921 Glutamate receptor 2 GRIA2 0.0117
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0117
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0117
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0116
3932 Glutathione S-transferase A2 GSTA2 0.0115
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0115
2981 Phospholipase A2, membrane associated PLA2G2A 0.0114
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0114
291 Nitric-oxide synthase, endothelial NOS3 0.0113
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0113
221 Lysyl-tRNA synthetase KARS 0.0112
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0112
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0112
1507 Cytochrome c CYCS 0.0112
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0111
494 Caspase-1 CASP1 0.0111
1353 DNA topoisomerase 1 TOP1 0.011
3552 DNA topoisomerase 1 topA 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
1050 Bile salt sulfotransferase SULT2A1 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
4760 Mll3241 protein mll3241 0.0109
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0108
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0108
613 Atrial natriuretic peptide receptor A NPR1 0.0106
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0105
6171 Solute carrier family 28 member 3 SLC28A3 0.0105
6165 Copper-transporting ATPase 1 ATP7A 0.0104
6163 Copper-transporting ATPase 2 ATP7B 0.0104
814 Ryanodine receptor 1 RYR1 0.0102
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0102
4192 DNA topoisomerase 2-beta TOP2B 0.0102
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0102
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0102
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0101
1770 Phospholipase C PLCL1 0.0101
2841 Phospholipase C plc 0.0101
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0101
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0101
1196 Complement decay-accelerating factor CD55 0.0101
634 Squalene monooxygenase SQLE 0.0101
7196 Squalene monooxygenase ERG1 0.0101
1830 5'-nucleotidase NT5E 0.01
319 Opioid receptor, sigma 1 OPRS1 0.01
3760 Penicillin-binding protein 5 precursor dacA 0.01
3587 Gastrotropin FABP6 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
84 Nuclear receptor 0B1 NR0B1 0.0099
702 UMP-CMP kinase CMPK1 0.0099
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
694 Matrix protein 2 M 0.0098
489 Monocarboxylate transporter 2 SLC16A7 0.0098
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0098
239 Coagulation factor X F10 0.0097
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0097
6211 Tubulin epsilon chain TUBE1 0.0097
6212 Tubulin gamma-1 chain TUBG1 0.0097
6210 Tubulin delta chain TUBD1 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
1405 Thiopurine S-methyltransferase TPMT 0.0097
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0096
5300 Antigen peptide transporter 1 TAP1 0.0096
3856 Fibroblast growth factor receptor 3 FGFR3 0.0096
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0096
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0095
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0095
3611 Cytidine deaminase cdd 0.0095
3707 Cytidine deaminase cdd 0.0095
4211 Cytidine deaminase CDA 0.0095
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0094
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0094
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0094
551 Carnitine O-acetyltransferase CRAT 0.0094
1650 Heme carrier protein 1 SLC46A1 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
1039 Histone deacetylase 9 HDAC9 0.0093
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0093
2077 Caspase-3 CASP3 0.0093
740 Argininosuccinate synthase ASS1 0.0092
865 Argininosuccinate synthase ASS1 0.0092
2680 Argininosuccinate synthase argG 0.0092
3194 Argininosuccinate synthase argG 0.0092
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0092
537 ATP synthase delta chain, mitochondrial ATP5D 0.0092
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0092
293 Gamma-glutamyl hydrolase GGH 0.0092
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0092
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0091
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0091
896 Glutathione S-transferase Mu 1 GSTM1 0.0091
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0091
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.009
819 Penicillin-binding protein 4 dacB 0.009
518 Peroxidase/catalase T katG 0.0089
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0089
499 Arginine decarboxylase ADC 0.0089
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0088
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0088
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0088
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
4311 tRNA TRDMT1 0.0087
4325 tRNA trmD 0.0087
4328 tRNA trmD 0.0087
88 Retinoic acid receptor RXR-beta RXRB 0.0086
6131 Carbonic anhydrase 14 CA14 0.0085
577 Argininosuccinate lyase ASL 0.0085
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0085
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0085
834 Arginase-2, mitochondrial ARG2 0.0084
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0084
174 Sigma 1-type opioid receptor SIGMAR1 0.0084
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0084
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0084
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
6044 Serum paraoxonase/lactonase 3 PON3 0.0082
277 Purine nucleoside phosphorylase PNP 0.0082
2870 Purine nucleoside phosphorylase punA 0.0082
2945 Purine nucleoside phosphorylase punA 0.0082
4659 Purine nucleoside phosphorylase TM_1596 0.0082
4825 Purine nucleoside phosphorylase TTHA1435 0.0082
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0081
1483 Membrane copper amine oxidase AOC3 0.0081
125 DNA polymerase beta POLB 0.0081
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0081
2021 Thrombomodulin THBD 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
1864 RET proto-oncogene RET 0.008
2417 Chloramphenicol acetyltransferase cat 0.008
3278 Chloramphenicol acetyltransferase cat 0.008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.008
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.008
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.008
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.008
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.008
2810 Dr hemagglutinin structural subunit draA 0.0079
517 Alcohol dehydrogenase 1C ADH1C 0.0079
6122 Carbonic anhydrase 3 CA3 0.0079
54 Prothrombin F2 0.0079
1275 Estrogen sulfotransferase SULT1E1 0.0079
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0079
173 Toll-like receptor 7 TLR7 0.0079
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0077
511 5-hydroxytryptamine 1F receptor HTR1F 0.0076
1541 Metalloproteinase mmp20 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
3957 Adenosine deaminase ADA 0.0073
6042 Prostaglandin reductase 2 PTGR2 0.0073
594 Thyroxine-binding globulin SERPINA7 0.0071
780 Retinoic acid receptor RXR-gamma RXRG 0.0071
6824 Tyrosine-protein kinase Lyn LYN 0.0071
6174 50S ribosomal protein L32 rpmF 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
1074 Urokinase-type plasminogen activator PLAU 0.0071
2216 Fibroblast growth factor receptor 4 FGFR4 0.007
268 Adenosine A2b receptor ADORA2B 0.0069
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0069
3007 Carbonic anhydrase 12 CA12 0.0069
4205 Carbonic anhydrase 9 CA9 0.0069
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0068
444 Alcohol dehydrogenase 1B ADH1B 0.0068
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0068
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0068
68 Cannabinoid receptor 1 CNR1 0.0068
3086 Plasmepsin-2 Not Available 0.0068
563 Thyroid peroxidase TPO 0.0068
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0067
3913 Glutamic acid decarboxylase GAD65 0.0066
1630 Integrin beta-2 ITGB2 0.0066
4103 Proteasome subunit beta type 2 PSMB2 0.0066
4102 Proteasome subunit beta type 5 PSMB5 0.0066
4101 Proteasome subunit beta type 1 PSMB1 0.0066
267 Plasminogen activator inhibitor 1 SERPINE1 0.0066
758 Thyroid hormone receptor alpha THRA 0.0066
6766 O-GlcNAcase BT_4395 BT_4395 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
251 Alcohol dehydrogenase 1A ADH1A 0.0065
5818 Folate receptor alpha FOLR1 0.0065
860 Nicotinamide N-methyltransferase NNMT 0.0064
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0064
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
459 Retinoic acid receptor RXR-alpha RXRA 0.0064
699 Nicotinic acid receptor 1 GPR109A 0.0064
928 Nicotinic acid receptor 2 GPR109B 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0062
162 Retinoic acid receptor gamma-1 RARG 0.0061
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0061
856 Vitamin D3 receptor VDR 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6221 Steroid hormone receptor ERR1 ESRRA 0.0059
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0059
346 Thyroid hormone receptor beta-1 THRB 0.0058
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0058
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
5880 Thrombopoietin receptor MPL 0.0058
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
4226 Uridine phosphorylase 2 UPP2 0.0057
788 Creatine kinase M-type CKM 0.0057
1313 Lactoylglutathione lyase GLO1 0.0056
3904 Alanine aminotransferase 2 GPT2 0.0056
735 Alanine aminotransferase 1 GPT 0.0056
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0055
1792 Tissue-type plasminogen activator PLAT 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
2391 Ferrochelatase hemH 0.0053
6502 Ferrochelatase DKFZp686P18130 0.0053
1591 Ferrochelatase, mitochondrial FECH 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
712 Tubulin alpha chain TUB1 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
4225 Uridine phosphorylase 1 UPP1 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
3937 Fatty-acid amide hydrolase FAAH 0.0051
581 Cytochrome P450 2R1 CYP2R1 0.005
572 Integrin alpha-L ITGAL 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.005
6048 Troponin C, skeletal muscle TNNC2 0.005
413 Amidophosphoribosyltransferase PPAT 0.0049
2515 Amidophosphoribosyltransferase purF 0.0049
3714 Amidophosphoribosyltransferase purF 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
3404 Exotoxin A eta 0.0049
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0049
2408 Tyrosine-protein kinase SYK SYK 0.0047
707 72 kDa type IV collagenase MMP2 0.0047
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
3830 Calreticulin CALR 0.0047
1253 Interferon gamma IFNG 0.0046
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0046
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0046
6493 Cytochrome c oxidase subunit 6C COX6C 0.0046
2230 Catalase CAT 0.0046
3249 Catalase katA 0.0046
3625 Catalase katA 0.0046
4539 Catalase katA 0.0046
4941 Catalase katB 0.0046
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0046
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0046
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0046
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0046
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0046
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0046
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0046
6559 Cytochrome c oxidase subunit 2 ctaC 0.0046
6669 Cytochrome c oxidase subunit 2 ctaC 0.0046
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0046
6558 Cytochrome c oxidase subunit 1 ctaD 0.0046
997 Protein kinase C beta type PRKCB 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0044
1374 Natriuretic peptides B NPPB 0.0044
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0044
1827 Gap junction alpha-1 protein GJA1 0.0044
1908 Vascular cell adhesion protein 1 VCAM1 0.0044
2236 Casein kinase II subunit alpha CSNK2A1 0.0044
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
117 Sterol O-acyltransferase 1 SOAT1 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
6034 Hydroxyindole O-methyltransferase ASMT 0.0043
6035 Nuclear receptor ROR-beta RORB 0.0043
6036 Eosinophil peroxidase EPX 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
2540 Choloylglycine hydrolase cbh 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1970 Protein kinase C alpha type PRKCA 0.0042
1714 Mitogen-activated protein kinase 3 MAPK3 0.0042
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0042
199 Monocarboxylate transporter 8 SLC16A2 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
408 Riboflavin kinase RFK 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
106 Cannabinoid receptor 2 CNR2 0.004
718 Folate receptor gamma FOLR3 0.004
299 Folate receptor beta FOLR2 0.004
804 Mitochondrial folate transporter/carrier SLC25A32 0.004
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.004
500 Monocarboxylate transporter 4 SLC16A3 0.004
6501 Fatty acid-binding protein, liver FABP1 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
5482 Sialidase-2 NEU2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1992 Vitamin D-binding protein GC 0.0038
719 Retinoic acid receptor responder protein 1 RARRES1 0.0038
770 Retinoic acid-induced protein 3 GPRC5A 0.0038
85 Growth hormone receptor GHR 0.0038
765 Indoleamine 2,3-dioxygenase IDO1 0.0038
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
1262 Corticotropin-lipotropin POMC 0.0035
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
6500 Phospholipase A2 PLA2G1B 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
611 Retinal dehydrogenase 1 ALDH1A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.003
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.003
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.003
654 Flavin reductase BLVRB 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
6459 Glycodelin PAEP 0.0028
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
5798 Mitogen-activated protein kinase 11 MAPK11 0.0027
2207 Rhodopsin RHO 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6859 Protein S100-A4 S100A4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
358 Cystathionine beta-synthase CBS 0.0025
340 Apoptotic protease-activating factor 1 APAF1 0.0024
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
760 Fibroblast growth factor 1 FGF1 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0022
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0022
825 Arsenical pump-driving ATPase ASNA1 0.0022
3435 Arsenical pump-driving ATPase arsA 0.0022
2232 Interleukin-5 IL5 0.0022
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0021
154 AFG3-like protein 2 AFG3L2 0.0021
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0021
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0021
733 Activin receptor type 1B ACVR1B 0.0021
76 Nitric-oxide synthase, brain NOS1 0.0021
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0021
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0021
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0021
395 ALK tyrosine kinase receptor Not Available 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
3221 Cytochrome c4 cc4 0.0021
822 Aldose reductase AKR1B1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
292 Activin receptor type-1 ACVR1 0.002
849 Activated CDC42 kinase 1 TNK2 0.002
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0019
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0019
297 Adenylate cyclase type 1 ADCY1 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
661 ADP/ATP translocase 1 SLC25A4 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
6021 Adenosine kinase ADK 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0015
6677 Myelin P2 protein PMP2 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6645 D-amino-acid oxidase DAO 0.0014
798 Osteocalcin BGLAP 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
369 Coagulation factor VII F7 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
1295 Fatty acid synthase FASN 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
2802 Endoglucanase G celCCG 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2132 Protein S100-B S100B 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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