DT-Web

DB01167 - Itraconazole


Identification
Name Itraconazole
Accession Number DB01167 (APRD00040)
Type small molecule
Description One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 705.633
Groups approved
Monoisotopic Weight 704.239307158
Pharmacology
Indication For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Mechanism of action Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Absorption The absolute oral bioavailability of itraconazole is 55%, and is maximal when taken with a full meal.
Protein binding 99.8%
Biotransformation Itraconazole is extensively metabolized by the liver into a large number of metabolites, including hydroxyitraconazole, the major metabolite. The main metabolic pathways are oxidative scission of the dioxolane ring, aliphatic oxidation at the 1-methylpropyl substituent, N-dealkylation of this 1-methylpropyl substituent, oxidative degradation of the piperazine ring and triazolone scission.
Route of elimination Itraconazole is metabolized predominately by the cytochrome P450 3A4 isoenzyme system (CYP3A4) in the liver, resulting in the formation of several metabolites, including hydroxyitraconazole, the major metabolite. Fecal excretion of the parent drug varies between 3-18% of the dose. Renal excretion of the parent drug is less than 0.03% of the dose. About 40% of the dose is excreted as inactive metabolites in the urine. No single excreted metabolite represents more than 5% of a dose.
Toxicity No significant lethality was observed when itraconazole was administered orally to mice and rats at dosage levels of 320 mg/kg or to dogs at 200 mg/kg.
Affected organisms
  • Fungi, yeast and protozoans
Interactions
Drug Interactions
Drug Mechanism of interaction
Abiraterone Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol Itraconazole may increase the anticoagulant effect of acenocoumarol.
Alfentanil Itraconazole may increase the effect and toxicity of alfentanil.
Alfuzosin The antifungal increases the effect of alfuzosin
Almotriptan This potent CYP3A4 inhibitor increases the effect and toxicity of the triptan
Alprazolam Itraconazole may increase the effect of the benzodiazepine, alprazolam.
Aluminium Aluminum-containing antacids may decrease the effect of itraconazole.
Anisindione Itraconazole may increase the anticoagulant effect of anisindione.
Apixaban Avoid combination. Otherwise, itraconazole will likely increase apixaban serum concentration.
Aprepitant This CYP3A4 inhibitor, itraconazole, may increase the effect and toxicity of aprepitant.
Aripiprazole Itraconazole may increase the effect of aripiprazole.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atorvastatin Increased risk of myopathy/rhabdomyolysis
Bosentan Itraconazole may increase the effect and toxicity of bosentan.
Bromazepam Itraconazole may increase the serum concentration of bromazepam by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if itraconazole is initiated, discontinued or dose changed.
Budesonide Itraconazole may increase levels/effect of budesonide.
Busulfan Itraconazole reduced busulfan clearance by up to 25% in patients receiving itraconazole compared to those that did not receive it. Concomitant therapy may lead to toxic plasma levels of busulfan.
Cabazitaxel Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Calcium Calcium-containing antacids may decrease the effect of itraconazole.
Calcium carbonate The antacid, calcium carbonate, may decrease the effect of itraconazole by decreasing its absorption.
Carbamazepine Itraconazole may increase the effect of carbamazepine.
Celiprolol Itaconazole increases levels/effect of celiprolol
Cerivastatin Increased risk of myopathy/rhabdomyolysis
Chlordiazepoxide Itraconazole may increase the effect of the benzodiazepine, chlordiazepoxide.
Ciclesonide Increased effects/toxicity of ciclesonide
Cilostazol Itraconazole may increase the effect of cilostazol.
Cimetidine The H2-receptor antagonist, cimetidine, may decrease the absorption of itraconazole.
Cinacalcet Itraconazole may increase the effect and toxicity of cinacalcet.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clarithromycin The macrolide, clarithromycin, may increase the effect and toxicity of itraconazole.
Clonazepam Itraconazole may increase the effect of the benzodiazepine, clonazepam.
Clorazepate Itraconazole may increase the effect of the benzodiazepine, clorazepate.
Conivaptan Antifungal Agents (Azole Derivatives, Systemic) may decrease the metabolism of Conivaptan. Concomitant use of conivaptan with strong CYP3A4 inhibitors (e.g., azole antifungals) is contraindicated.
Cyclosporine Itraconazole may increase the effect of cyclosporine.
Dantrolene Itraconazole may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if itraconazole is initiated, discontinued or dose changed.
Darifenacin This potent CYP3A4 inhibitor slows darifenacin/solifenacin metabolism
Diazepam Itraconazole may increase the effect of the benzodiazepine, diazepam.
Dicumarol Itraconazole may increase the anticoagulant effect of dicumarol.
Digoxin Itraconazole increases the effect of digoxin
Dihydroergotamine Possible ergotism and severe ischemia with this combination
Dofetilide This strong CYP3A4 inhibitor increases the effect and toxicity of dofetilide
Dronedarone Itraconazole is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Eletriptan This potent CYP3A4 inhibitor increases the effect and toxicity of the triptan
Eplerenone Itraconazole may increase the effect and toxicity of eplerenone.
Ergotamine Possible ergotism and severe ischemia with this combination
Erlotinib Itraconazole may decrease the metabolism of erlotinib. Monitor for changes in the therapeutic and adverse effects of erlotinib if itraconazole is initiated, discontinued or dose changed.
Erythromycin The macrolide, erythromycin, may increase the effect and toxicity of itraconazole.
Esomeprazole The proton pump inhibitor, esomeprazole, may decrease the absorption of itraconazole.
Estazolam Itraconazole may increase the effect of the benzodiazepine, estazolam.
Ethotoin Phenytoin decreases the effect of itraconazole
Everolimus Itraconazole may increase everolimus levels/toxicity.
Famotidine The H2-receptor antagonist, famotidine, may decrease the absorption of itraconazole.
Felodipine Itraconazole may increase the therapeutic and adverse effects of felodipine.
Fentanyl Itraconazole may increase levels/toxicity of fentanyl.
Flurazepam Itraconazole may increase the effect of the benzodiazepine, flurazepam.
Fosphenytoin Phenytoin decreases the effect of itraconazole
Gefitinib Itraconazole, a strong CYP3A4 inhibitor, may decrease the metabolism of gefitinib. Monitor for changes in the therapeutic and adverse effects of gefitinib if itraconazole is initiated, discontinued or dose changed.
Halazepam Itraconazole may increase the effect of the benzodiazepine, halazepam.
Haloperidol Itraconazole may increase the effect and toxicity of haloperidol.
Imatinib Itraconazole may increase the levels of imatinib.
Ivacaftor Strong CYP3A4 inhibitors may increase levels of ivacaftor. Monitor concomitant therapy closely.
Josamycin The macrolide, josamycin, may increase the effect and toxicity of itraconazole.
Lansoprazole The proton pump inhibitor, lansoprazole, may decrease the absorption of itraconazole.
Levomethadyl Acetate Itraconazole increases the effect/toxicity of levomethadyl
Lovastatin Increased risk of myopathy/rhabdomyolysis
Lurasidone Concomitant therapy with a strong CYP3A4 inhibitor will increase level or effect of lurasidone. Coadministration with lurasidone is contraindicated.
Magnesium oxide The antacid, magnesium oxide, may decrease the effect of itraconazole by decreasing its absorption.
Mephenytoin Phenytoin decreases the effect of itraconazole
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methylprednisolone The imidazole, itraconazole, may increase the effect and toxicity of the corticosteroid, methylprednisolone.
Midazolam Itraconazole may increase the effect of the benzodiazepine, midazolam.
Nizatidine The H2-receptor antagonist, nizatidine, may decrease the absorption of itraconazole.
Omeprazole The proton pump inhibitor, omeprazole, may decrease the absorption of itraconazole.
Pantoprazole The proton pump inhibitor, pantoprazole, may decrease the absorption of itraconazole.
Pazopanib Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Phenobarbital The barbiturate, phenobarbital, decreases the effect of itraconazole.
Phenytoin Phenytoin decreases the effect of itraconazole
Pimozide Increased risk of cardiotoxicity and arrhythmias
Ponatinib Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Prednisolone The imidazole, itraconazole, may increase the effect and toxicity of the corticosteroid, prednisolone.
Prednisone The imidazole, itraconazole, may increase the effect and toxicity of the corticosteroid, prednisone.
Quazepam Itraconazole may increase the effect of the benzodiazepine, quazepam.
Quinidine Itraconazole may increase the effect and toxicity of quinidine.
Quinidine barbiturate Itraconazole may increase the effect and toxicity of quinidine barbiturate.
Rabeprazole The proton pump inhibitor, rabeprazole, may decrease the absorption of itraconazole.
Ranitidine The H2-receptor antagonist, ranitidine, may decrease the absorption of itraconazole.
Ranolazine Increased levels of ranolazine - risk of toxicity
Regorafenib Strong CYP3A4 inhibitors may increase levels of regorafenib.
Rifabutin Rifabutin decreases the effect of itraconazole
Rifampin Rifampin may decrease the effect of itraconazole.
Risperidone Increases the level of risperidone
Ritonavir Itraconazole may increase the effect and toxicity of ritonavir.
Rivaroxaban Use of rivaroxaban with agents that are strong inhibitors of both CYP3A4 and P-glycoproteins are contraindicated.
Ruxolitinib Strong CYP3A4 inhibitors may increase levels of ruxolitinib. Consider alternate therapy.
Sildenafil Itraconazole may increase the effect and toxicity of sildenafil.
Silodosin Strong CYP3A4 inhibitors may increase levels of silodosin. Concomitant administration is contraindicated.
Simvastatin Increased risk of myopathy/rhabdomyolysis
Sirolimus Itraconazole may increase the effect and toxicity of sirolimus.
Solifenacin This potent CYP3A4 inhibitor slows darifenacin/solifenacin metabolism
Sucralfate Sucralfate may decrease the absorption of itraconazole.
Sunitinib Possible increase in sunitinib levels
Tacrolimus The antifungal, Itraconazole, may increase serum concentrations of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Itraconazole therapy is initiated, discontinued or altered.
Tadalafil Itraconazole may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Itraconazole may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Tamsulosin Itraconazole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Itraconazole is initiated, discontinued, or dose changed.
Telithromycin Itraconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects.
Temsirolimus Itraconazole may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Itraconazole, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Itraconazole is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tiagabine The strong CYP3A4 inhibitor, Itraconazole, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Itraconazole is initiated, discontinued or dose changed.
Tipranavir Tipranavir may increase the serum concentration of Itraconazole.
Tolterodine Itraconazole may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tolvaptan Itraconazole is a strong inhibitor of CYP3A4 and will increase serum concentrations of tolvaptan.
Topotecan The p-glycoprotein inhibitor, Itraconazole, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tramadol Itraconazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor, Itraconazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Itraconazole is initiated, discontinued or dose changed.
Triazolam Itraconazole may increase the effect of the benzodiazepine, triazolam.
Trimipramine The strong CYP3A4 inhibitor, Itraconazole, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Itraconazole is initiated, discontinued or dose changed.
Ulipristal Concomitant therapy with strong CYP3A4 inhibitors may increase plasma concentrations of ulipristal. Avoid combination therapy.
Vardenafil Itraconazole, a potent CYP3A4 inhibitor, may decrease the metabolism and clearance of Vardenafil. Concomitant therapy is contraindicated.
Vemurafenib Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Venlafaxine Itraconaole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Itraconazole is initiated, discontinued, or dose changed.
Verapamil Itraconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Itraconazole is initiated, discontinued or dose changed.
Vinblastine Itraconazole, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Itraconazole is initiated, discontinued or dose changed.
Vincristine Itraconazole, a strong CYP3A4 and p-glycoprotein inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism and/or increasing efflux. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Itraconazole is initiated, discontinued or dose changed.
Vinorelbine Itraconazole, a strong CYP3A4 and p-glycoprotein inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism and/or increasing its efflux. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Itraconazole is initiated, discontinued or dose changed.
Warfarin Itraconazole may increase the anticoagulant effect of warfarin by decreasing its metabolism.
Zolpidem Itraconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if itraconazole is initiated, discontinued or dose changed.
Zonisamide Itraconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if itraconazole is initiated, discontinued or dose changed.
Zopiclone Itraconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if itraconzole is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.
  • Take after a full meal.
  • Avoid taking with grapefruit juice.
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.

Targets


Cytochrome P450 51A1
Name Cytochrome P450 51A1
Gene Name CYP51A1
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Cotrim PC, Garrity LK, Beverley SM: Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection. J Biol Chem. 1999 Dec 31;274(53):37723-30. - Pubmed
  • Carrillo-Munoz AJ, Giusiano G, Ezkurra PA, Quindos G: Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9. - Pubmed
DTHybrid score 0.5415
Cytochrome P450 51
Name Cytochrome P450 51
Gene Name ERG11
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gachotte D, Pierson CA, Lees ND, Barbuch R, Koegel C, Bard M: A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11173-8. - Pubmed
  • Henry KW, Nickels JT, Edlind TD: Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother. 2000 Oct;44(10):2693-700. - Pubmed
  • Morales IJ, Vohra PK, Puri V, Kottom TJ, Limper AH, Thomas CF Jr: Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii. Am J Respir Cell Mol Biol. 2003 Aug;29(2):232-8. Epub 2003 Feb 26. - Pubmed
DTHybrid score 0.1794

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor
References
DTHybrid score 0.486
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inhibitor
References
DTHybrid score 0.3941
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. - Pubmed
  • Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7978
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5641
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed
DTHybrid score 0.3869
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3351
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3719

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
  • Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW: Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother. 2002 Jan;46(1):160-5. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Takara K, Tanigawara Y, Komada F, Nishiguchi K, Sakaeda T, Okumura K: Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs. Biol Pharm Bull. 1999 Dec;22(12):1355-9. - Pubmed
  • Masuda S, Inui K: [Molecular mechanisms on drug transporters in the drug absorption and disposition] Nippon Rinsho. 2002 Jan;60(1):65-73. - Pubmed
  • Lilja JJ, Backman JT, Laitila J, Luurila H, Neuvonen PJ: Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol. Clin Pharmacol Ther. 2003 Mar;73(3):192-8. - Pubmed
  • Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. - Pubmed
  • Saito M, Hirata-Koizumi M, Miyake S, Hasegawa R: Comparison of information on the pharmacokinetic interactions of Ca antagonists in the package inserts from three countries (Japan, USA and UK). Eur J Clin Pharmacol. 2005 Aug;61(7):531-6. Epub 2005 Jul 23. - Pubmed
  • Shon JH, Yoon YR, Hong WS, Nguyen PM, Lee SS, Choi YG, Cha IJ, Shin JG: Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism. Clin Pharmacol Ther. 2005 Aug;78(2):191-201. - Pubmed
DTHybrid score 0.5081

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.3425
4757 Cytochrome P450 2C9 CYP2C9 0.3216
6016 Cytochrome P450 2C19 CYP2C19 0.313
4924 Cytochrome P450 2C8 CYP2C8 0.2631
260 Cytochrome P450 51 ERG11 0.1794
3163 Cytochrome P450 51 cyp51 0.1794
6562 Putative cytochrome P450 130 cyp130 0.143
5718 Cytochrome P450 2A6 CYP2A6 0.1388
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1052
587 Serum albumin ALB 0.0859
492 Histamine H1 receptor HRH1 0.0811
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0768
1898 Cytochrome P450 1B1 CYP1B1 0.0738
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0717
3811 Cytochrome P450 19A1 CYP19A1 0.0702
824 Sodium-dependent serotonin transporter SLC6A4 0.0702
862 Multidrug resistance-associated protein 1 ABCC1 0.067
1181 Alpha-1-acid glycoprotein 1 ORM1 0.066
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0656
20 Prostaglandin G/H synthase 1 PTGS1 0.0607
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0606
6106 Cytochrome P450 2C18 CYP2C18 0.0602
831 D(2) dopamine receptor DRD2 0.0581
556 Alpha-1A adrenergic receptor ADRA1A 0.058
6145 Solute carrier family 22 member 1 SLC22A1 0.0578
776 Bile salt export pump ABCB11 0.0567
502 5-hydroxytryptamine 2A receptor HTR2A 0.0543
847 Mu-type opioid receptor OPRM1 0.0515
103 Muscarinic acetylcholine receptor M1 CHRM1 0.05
6144 Solute carrier family 22 member 2 SLC22A2 0.0475
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0461
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0454
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0449
871 Glucocorticoid receptor NR3C1 0.0444
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0441
320 5-hydroxytryptamine 1A receptor HTR1A 0.0433
766 Beta-2 adrenergic receptor ADRB2 0.042
1729 Solute carrier family 22 member 6 SLC22A6 0.042
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0412
318 Alpha-2A adrenergic receptor ADRA2A 0.0409
193 Beta-1 adrenergic receptor ADRB1 0.0404
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0396
6031 Cytochrome P450 3A43 CYP3A43 0.0392
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0382
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0382
467 Delta-type opioid receptor OPRD1 0.0364
713 Sodium-dependent dopamine transporter SLC6A3 0.0362
136 Estrogen receptor ESR1 0.0359
468 Cytochrome P450 4A11 CYP4A11 0.0356
118 Organic cation/carnitine transporter 2 SLC22A5 0.0356
590 5-hydroxytryptamine 2C receptor HTR2C 0.0346
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0337
632 Alpha-1B adrenergic receptor ADRA1B 0.0334
23 D(1A) dopamine receptor DRD1 0.0332
696 Kappa-type opioid receptor OPRK1 0.0331
731 HIV-1 protease HIV-1 protease 0.0329
465 Calmodulin CALM1 0.0327
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0323
341 5-hydroxytryptamine 3 receptor HTR3A 0.0316
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0316
6147 Solute carrier family 22 member 3 SLC22A3 0.0307
638 D(3) dopamine receptor DRD3 0.0307
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0303
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0299
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0298
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0296
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0294
290 Prostaglandin G/H synthase 2 PTGS2 0.0288
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0281
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0277
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0274
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0263
817 DNA topoisomerase 2-alpha TOP2A 0.0262
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0262
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0262
833 Organic cation/carnitine transporter 1 SLC22A4 0.026
6143 Solute carrier family 22 member 7 SLC22A7 0.0258
6142 Solute carrier family 22 member 8 SLC22A8 0.0256
3923 Cholinesterase BCHE 0.0251
6182 Cytochrome P450 2J2 CYP2J2 0.025
2164 Multidrug resistance-associated protein 4 ABCC4 0.0241
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0237
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0237
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0232
885 5-hydroxytryptamine 1B receptor HTR1B 0.0232
6148 Multidrug resistance-associated protein 7 ABCC10 0.0232
3941 Amine oxidase [flavin-containing] A MAOA 0.0231
614 Progesterone receptor PGR 0.022
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0217
789 Alpha-1D adrenergic receptor ADRA1D 0.0214
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0214
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0211
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0207
777 Tumor necrosis factor TNF 0.0205
378 Alpha-2C adrenergic receptor ADRA2C 0.0205
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0205
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0202
629 Alpha-2B adrenergic receptor ADRA2B 0.0201
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.02
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.02
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0195
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0193
844 Epidermal growth factor receptor EGFR 0.0191
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0191
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0191
4604 Liver carboxylesterase 1 CES1 0.0189
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0188
122 P2Y purinoceptor 12 P2RY12 0.0186
737 Mineralocorticoid receptor NR3C2 0.0183
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
725 5-hydroxytryptamine 1D receptor HTR1D 0.0179
432 D(4) dopamine receptor DRD4 0.0177
5934 Cytochrome P450 26A1 CYP26A1 0.0176
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0176
504 Mast/stem cell growth factor receptor KIT 0.0175
3939 Amine oxidase [flavin-containing] B MAOB 0.0175
6220 Aryl hydrocarbon receptor AHR 0.0172
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0172
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.017
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0169
811 Translocator protein TSPO 0.0168
4120 NADPH--cytochrome P450 reductase POR 0.0168
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0168
705 Glutamate receptor 1 GRIA1 0.0168
6014 Cytochrome P450 2A13 CYP2A13 0.0167
756 Sex hormone-binding globulin SHBG 0.0166
232 Corticosteroid-binding globulin SERPINA6 0.0166
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0164
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0158
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0157
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0157
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0157
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0157
818 50S ribosomal protein L10 rplJ 0.0154
146 Androgen receptor AR 0.0154
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0152
716 5-hydroxytryptamine 7 receptor HTR7 0.015
482 Glycine receptor subunit alpha-1 GLRA1 0.0148
161 Tubulin beta chain TUBB 0.0148
312 Tubulin beta chain TUB2 0.0148
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0148
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0147
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0147
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0147
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0147
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0147
613 Atrial natriuretic peptide receptor A NPR1 0.0146
380 Cytochrome P450 17A1 CYP17A1 0.0145
6137 Multidrug resistance-associated protein 6 ABCC6 0.0144
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0144
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0142
29 Tubulin beta-1 chain TUBB1 0.014
6136 Multidrug resistance-associated protein 5 ABCC5 0.014
16 Adenosine A1 receptor ADORA1 0.0138
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0137
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0136
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0136
3932 Glutathione S-transferase A2 GSTA2 0.0135
436 5-hydroxytryptamine 2B receptor HTR2B 0.0135
2449 Tubulin alpha-3 chain TUBA1A 0.0135
1178 Adenosine A2a receptor ADORA2A 0.0134
228 Beta platelet-derived growth factor receptor PDGFRB 0.0133
124 Histamine H2 receptor HRH2 0.0133
94 5-hydroxytryptamine 4 receptor HTR4 0.0133
869 Estrogen receptor beta ESR2 0.0132
174 Sigma 1-type opioid receptor SIGMAR1 0.0132
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0132
3947 Xanthine dehydrogenase/oxidase XDH 0.013
6141 Sodium/bile acid cotransporter SLC10A1 0.013
2499 Tubulin beta-2C chain TUBB2C 0.0129
1192 Sulfotransferase 1A1 SULT1A1 0.0128
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0128
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0127
1656 CYP2B protein CYP2B 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
477 DNA topoisomerase 4 subunit A parC 0.0126
886 DNA topoisomerase 4 subunit A parC 0.0126
6226 DNA topoisomerase 4 subunit A parC 0.0126
952 Dipeptidyl peptidase 4 DPP4 0.0126
474 Acetylcholinesterase ACHE 0.0126
1517 Beta-3 adrenergic receptor ADRB3 0.0125
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0124
404 DNA gyrase subunit A gyrA 0.0124
6224 DNA gyrase subunit A gyrA 0.0124
26 Vascular endothelial growth factor receptor 3 FLT4 0.0123
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0121
537 ATP synthase delta chain, mitochondrial ATP5D 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0119
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0119
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0118
407 Vascular endothelial growth factor receptor 2 KDR 0.0118
32 Vascular endothelial growth factor receptor 1 FLT1 0.0118
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0116
48 Pyridoxal kinase PDXK 0.0116
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0116
1024 Solute carrier family 22 member 11 SLC22A11 0.0116
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0115
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0115
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0114
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
6020 Aldehyde oxidase AOX1 0.0112
1256 5-hydroxytryptamine 6 receptor HTR6 0.0112
1757 Myeloperoxidase MPO 0.011
2112 Toll-like receptor 9 TLR9 0.0109
131 Synaptic vesicular amine transporter SLC18A2 0.0108
6102 Arylamine N-acetyltransferase 2 NAT2 0.0107
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0107
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0107
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0107
723 Cytosolic phospholipase A2 PLA2G4A 0.0106
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0105
163 D(1B) dopamine receptor DRD5 0.0105
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0103
790 DNA polymerase subunit alpha B POLA2 0.0103
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0101
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0101
950 Alpha platelet-derived growth factor receptor PDGFRA 0.01
768 FK506-binding protein 1A FKBP1A 0.01
427 Substance-P receptor TACR1 0.0096
814 Ryanodine receptor 1 RYR1 0.0095
4237 50S ribosomal protein L22 rplV 0.0095
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0095
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0095
373 Transthyretin TTR 0.0095
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0094
84 Nuclear receptor 0B1 NR0B1 0.0091
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0091
295 Carbonic anhydrase 1 CA1 0.0091
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.009
1353 DNA topoisomerase 1 TOP1 0.0089
3552 DNA topoisomerase 1 topA 0.0089
4203 Histamine N-methyltransferase HNMT 0.0089
4122 Histone deacetylase 2 HDAC2 0.0088
891 Dihydropteroate synthase folP 0.0088
5359 Dihydropteroate synthase folP 0.0088
7175 Dihydropteroate synthase sulI 0.0088
319 Opioid receptor, sigma 1 OPRS1 0.0088
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0088
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0087
6766 O-GlcNAcase BT_4395 BT_4395 0.0087
469 Annexin A1 ANXA1 0.0085
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0085
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0085
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0084
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0083
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
4238 50S ribosomal protein L4 rplD 0.0083
5578 50S ribosomal protein L4 rplD 0.0083
6173 50S ribosomal protein L4 rplD 0.0083
6219 50S ribosomal protein L4 rplD 0.0083
823 Fibroblast growth factor receptor 2 FGFR2 0.0083
165 FL cytokine receptor FLT3 0.0083
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0082
528 5-hydroxytryptamine 1E receptor HTR1E 0.0081
6138 Multidrug resistance protein 3 ABCB4 0.0081
606 Cytochrome P450 27, mitochondrial CYP27A1 0.008
1050 Bile salt sulfotransferase SULT2A1 0.008
1852 Microtubule-associated protein 2 MAP2 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0077
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0077
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0077
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
2539 Tubulin alpha-1 chain TUBA4A 0.0076
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0076
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0075
820 Glycine receptor subunit alpha-2 GLRA2 0.0075
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0075
444 Alcohol dehydrogenase 1B ADH1B 0.0074
208 DNA-directed RNA polymerase beta' chain rpoC 0.0074
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0074
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0073
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0073
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0073
4311 tRNA TRDMT1 0.0072
4325 tRNA trmD 0.0072
4328 tRNA trmD 0.0072
239 Coagulation factor X F10 0.0072
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0071
738 Monocarboxylate transporter 1 SLC16A1 0.0071
251 Alcohol dehydrogenase 1A ADH1A 0.0071
976 Platelet glycoprotein IX GP9 0.0071
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.007
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.007
4228 Keratin, type II cytoskeletal 7 KRT7 0.007
904 Glutathione S-transferase P GSTP1 0.007
68 Cannabinoid receptor 1 CNR1 0.007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0069
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0067
70 Type-1 angiotensin II receptor AGTR1 0.0066
592 Carbonic anhydrase 4 CA4 0.0066
33 Cystine/glutamate transporter SLC7A11 0.0065
921 Glutamate receptor 2 GRIA2 0.0065
856 Vitamin D3 receptor VDR 0.0064
153 Dopamine beta-hydroxylase DBH 0.0064
1629 Transcription factor AP-1 JUN 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0063
6432 Transporter snf 0.0063
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
1618 High affinity nerve growth factor receptor NTRK1 0.0062
1483 Membrane copper amine oxidase AOC3 0.0062
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0062
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0061
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.006
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
365 Dihydrofolate reductase DHFR 0.0059
2381 Dihydrofolate reductase DFR1 0.0059
2833 Dihydrofolate reductase Not Available 0.0059
2931 Dihydrofolate reductase folA 0.0059
3544 Dihydrofolate reductase folA 0.0059
3682 Dihydrofolate reductase folA 0.0059
6642 Dihydrofolate reductase folA 0.0059
6756 Dihydrofolate reductase dfrA 0.0059
5923 Microtubule-associated protein tau MAPT 0.0059
5924 Microtubule-associated protein 4 MAP4 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0058
6043 Putative G-protein coupled receptor 44 GPR44 0.0058
284 DNA-directed RNA polymerase beta chain rpoB 0.0058
5773 DNA-directed RNA polymerase beta chain rpoB 0.0058
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0058
6146 High affinity copper uptake protein 1 SLC31A1 0.0057
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
517 Alcohol dehydrogenase 1C ADH1C 0.0057
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0056
581 Cytochrome P450 2R1 CYP2R1 0.0056
54 Prothrombin F2 0.0056
3809 Estrogen-related receptor gamma ESRRG 0.0056
273 Apoptosis regulator Bcl-2 BCL2 0.0056
7 Nitric oxide synthase, inducible NOS2 0.0056
6085 Fatty acid-binding protein, intestinal FABP2 0.0056
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0055
6126 Carbonic anhydrase 7 CA7 0.0055
6506 Stathmin-4 STMN4 0.0055
4773 Deoxycytidine kinase DCK 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
569 Retinal dehydrogenase 2 ALDH1A2 0.0054
1630 Integrin beta-2 ITGB2 0.0054
1714 Mitogen-activated protein kinase 3 MAPK3 0.0054
780 Retinoic acid receptor RXR-gamma RXRG 0.0053
563 Thyroid peroxidase TPO 0.0053
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0053
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0053
908 Glutathione S-transferase theta-1 GSTT1 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
4192 DNA topoisomerase 2-beta TOP2B 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
5300 Antigen peptide transporter 1 TAP1 0.0051
611 Retinal dehydrogenase 1 ALDH1A1 0.0051
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0051
4103 Proteasome subunit beta type 2 PSMB2 0.005
4102 Proteasome subunit beta type 5 PSMB5 0.005
4101 Proteasome subunit beta type 1 PSMB1 0.005
357 Carbonic anhydrase 2 CA2 0.005
3937 Fatty-acid amide hydrolase FAAH 0.0049
719 Retinoic acid receptor responder protein 1 RARRES1 0.0049
770 Retinoic acid-induced protein 3 GPRC5A 0.0049
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0049
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0049
3601 Dihydropteroate synthase 1 folP1 0.0049
3807 Dihydropteroate synthase 1 folP1 0.0049
3808 Dihydropteroate synthase 2 folP2 0.0049
3404 Exotoxin A eta 0.0049
173 Toll-like receptor 7 TLR7 0.0049
88 Retinoic acid receptor RXR-beta RXRB 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
751 Potassium channel subfamily K member 6 KCNK6 0.0048
1176 Mitogen-activated protein kinase 1 MAPK1 0.0047
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
1374 Natriuretic peptides B NPPB 0.0046
1827 Gap junction alpha-1 protein GJA1 0.0046
1908 Vascular cell adhesion protein 1 VCAM1 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
3086 Plasmepsin-2 Not Available 0.0046
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0046
3913 Glutamic acid decarboxylase GAD65 0.0046
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0046
275 Arachidonate 5-lipoxygenase ALOX5 0.0046
2230 Catalase CAT 0.0045
3249 Catalase katA 0.0045
3625 Catalase katA 0.0045
4539 Catalase katA 0.0045
4941 Catalase katB 0.0045
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
936 Ephrin type-A receptor 2 EPHA2 0.0044
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0044
3810 Catechol O-methyltransferase COMT 0.0044
172 Potassium channel subfamily K member 1 KCNK1 0.0044
1820 Beta-nerve growth factor NGF 0.0044
4116 Dihydropteroate synthetase Not Available 0.0044
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
1992 Vitamin D-binding protein GC 0.0043
106 Cannabinoid receptor 2 CNR2 0.0043
267 Plasminogen activator inhibitor 1 SERPINE1 0.0043
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0042
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0042
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0042
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0042
1196 Complement decay-accelerating factor CD55 0.0042
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0042
183 Vascular endothelial growth factor A VEGFA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.004
65 Matrix metalloproteinase-9 Not Available 0.004
3856 Fibroblast growth factor receptor 3 FGFR3 0.004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.004
1262 Corticotropin-lipotropin POMC 0.004
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0039
3426 Glutamine synthetase glnA 0.0039
3987 Glutamine synthetase GLUL 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
518 Peroxidase/catalase T katG 0.0039
162 Retinoic acid receptor gamma-1 RARG 0.0039
3904 Alanine aminotransferase 2 GPT2 0.0038
735 Alanine aminotransferase 1 GPT 0.0038
6221 Steroid hormone receptor ERR1 ESRRA 0.0038
5787 Angiopoietin-1 receptor TEK 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
1569 G1/S-specific cyclin-D1 CCND1 0.0038
2236 Casein kinase II subunit alpha CSNK2A1 0.0038
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0037
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0037
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0037
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
1063 Signal transducer and activator of transcription 5B STAT5B 0.0037
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
2808 Chloramphenicol acetyltransferase 3 cat3 0.0036
6048 Troponin C, skeletal muscle TNNC2 0.0035
896 Glutathione S-transferase Mu 1 GSTM1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
634 Squalene monooxygenase SQLE 0.0035
7196 Squalene monooxygenase ERG1 0.0035
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0035
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0035
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
268 Adenosine A2b receptor ADORA2B 0.0034
6163 Copper-transporting ATPase 2 ATP7B 0.0034
6165 Copper-transporting ATPase 1 ATP7A 0.0034
6044 Serum paraoxonase/lactonase 3 PON3 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
2417 Chloramphenicol acetyltransferase cat 0.0033
3278 Chloramphenicol acetyltransferase cat 0.0033
1275 Estrogen sulfotransferase SULT1E1 0.0033
484 Tyrosine-protein kinase ABL2 ABL2 0.0033
2810 Dr hemagglutinin structural subunit draA 0.0032
6174 50S ribosomal protein L32 rpmF 0.0032
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0032
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0032
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0032
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0032
6131 Carbonic anhydrase 14 CA14 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
3957 Adenosine deaminase ADA 0.0032
3917 Methylenetetrahydrofolate reductase MTHFR 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
164 Histamine H4 receptor HRH4 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0031
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0031
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0031
572 Integrin alpha-L ITGAL 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1650 Heme carrier protein 1 SLC46A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1864 RET proto-oncogene RET 0.003
400 Coagulation factor IX F9 0.003
5461 Coagulation factor IX F9 0.003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.003
6122 Carbonic anhydrase 3 CA3 0.003
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0029
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0029
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
2298 Cytochrome P450-cam camC 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
24 Thymidylate synthase TMP1 0.0027
359 Thymidylate synthase TYMS 0.0027
2626 Thymidylate synthase thyA 0.0027
2729 Thymidylate synthase thyA 0.0027
5352 Thymidylate synthase THYA 0.0027
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0027
604 Vitamin K-dependent protein Z PROZ 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
1360 Sphingomyelin phosphodiesterase SMPD1 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0027
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0026
2408 Tyrosine-protein kinase SYK SYK 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
291 Nitric-oxide synthase, endothelial NOS3 0.0026
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0026
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0026
49 Endothelin B receptor EDNRB 0.0026
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0025
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0025
1268 Neuropeptide S receptor NPSR1 0.0025
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0025
422 Vitamin K-dependent protein C PROC 0.0025
1245 Vitamin K-dependent protein S PROS1 0.0025
358 Cystathionine beta-synthase CBS 0.0025
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0024
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
2981 Phospholipase A2, membrane associated PLA2G2A 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0024
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
6073 Potassium channel subfamily K member 9 KCNK9 0.0023
6072 Potassium channel subfamily K member 3 KCNK3 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
2207 Rhodopsin RHO 0.0022
2599 Tyrosine-protein kinase HCK HCK 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
997 Protein kinase C beta type PRKCB 0.0021
298 Renin REN 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
3007 Carbonic anhydrase 12 CA12 0.0021
4205 Carbonic anhydrase 9 CA9 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
798 Osteocalcin BGLAP 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
1970 Protein kinase C alpha type PRKCA 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
6459 Glycodelin PAEP 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
3830 Calreticulin CALR 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5798 Mitogen-activated protein kinase 11 MAPK11 0.0018
369 Coagulation factor VII F7 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1039 Histone deacetylase 9 HDAC9 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
6034 Hydroxyindole O-methyltransferase ASMT 0.0017
6035 Nuclear receptor ROR-beta RORB 0.0017
6036 Eosinophil peroxidase EPX 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
3221 Cytochrome c4 cc4 0.0016
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0016
822 Aldose reductase AKR1B1 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0016
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0016
3233 Bile acid receptor NR1H4 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
765 Indoleamine 2,3-dioxygenase IDO1 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1341 Histamine H3 receptor HRH3 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
85 Growth hormone receptor GHR 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
6859 Protein S100-A4 S100A4 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4217 Telomerase reverse transcriptase TERT 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
345 Plasma retinol-binding protein RBP4 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
6218 Pannexin-1 PANX1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2021 Thrombomodulin THBD 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4943 Cytochrome c6 petJ 0.0004
4984 Neuroglobin NGB 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4909 CooA protein cooA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4972 P450cin cinA 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4961 Hemophore HasA hasA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4952 Catalase/peroxidase katA 0.0004
3093 Catalase HPII katE 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
4920 Peroxidase/catalase katG 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
1507 Cytochrome c CYCS 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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