DT-Web: DB06772

Identification

Name

Cabazitaxel

Accession Number

DB06772

Type

small molecule

Description

Cabazitaxel is an anti-neoplastic used with the steroid medicine prednisone. Cabazitaxel is used to treat people with prostate cancer that has progressed despite treatment with docetaxel. Cabazitaxel is prepared by semi-synthesis with a precursor extracted from yew needles (10-deacetylbaccatin III). It was approved by the U.S. Food and Drug Administration (FDA) on June 17, 2010.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

835.9324

Groups

approved

Monoisotopic Weight

835.377905537

Pharmacology

Indication

For treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.

Mechanism of action

Cabazitaxel is a microtubule inhibitor. Cabazitaxel binds to tubulin and promotes its assembly into microtubules while simultaneously inhibiting disassembly. This leads to the stabilization of microtubules, which results in the interference of mitotic and interphase cellular functions. The cell is then unable to progress further into the cell cycle, being stalled at metaphase, thus triggering apoptosis of the cancer cell.

Absorption

After an intravenous dose of cabazitaxel 25 mg/m2 every three weeks to a population of 170 patients with solid tumors, the mean Cmax in patients with metastatic prostate cancer was 226 ng/mL (CV 107%) and was reached at the end of the one-hour infusion (Tmax). The mean AUC in patients with metastatic prostate cancer was 991 ng.h/mL (CV 34%). Administration with prednisone or prednisolone do not effect the pharmacokinetic profile of cabazitaxel.

Protein binding

Cabazitaxel is mainly bound to human serum albumin (82%) and lipoproteins (88% for HDL, 70% for LDL, and 56% for VLDL).

Biotransformation

Cabazitaxel is extensively metabolized in the liver (>95%), mainly by the CYP3A4/5 isoenzyme (80% to 90%), and to a lesser extent by CYP2C8 which results in 20 different metabolites. Two of these metabolites are active demethylated derivatives of cabaxitaxel and referred to as RPR112698 and RPR123142 respectively. Docetaxel is another metabolite of cabazitaxel. Cabazitaxel is the main circulating moiety in human plasma.

Route of elimination

After a one-hour intravenous infusion [14C]-cabazitaxel 25 mg/m2, approximately 80% of the administered dose was eliminated within 2 weeks. Cabazitaxel is mainly excreted in the feces as numerous metabolites (76% of the dose); while renal excretion of cabazitaxel and metabolites account for 3.7% of the dose (2.3% as unchanged drug in urine).

Toxicity

Cabazitaxel may cause serious side effects including neutropenia, hypersensitivity reactions, gastrointestinal symptoms, and renal failure. Anticipated complications of overdose include exacerbation of adverse reactions such as bone marrow suppression and gastrointestinal disorders. Cabazitaxel penetrates the blood-brain barrier. LD50, rat = 500 mg/kg

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Carbamazepine	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Cisplatin	Platinum derivatives such as cisplatin may enhance the myelosuppressive effect of taxane derivatives such as cabazitaxel. Administer taxane derivative before platinum derivative when given as sequential infusions to limit toxicity.Administer paclitaxel before cisplatin, when given as sequential infusions, to limit toxicity. Problems associated with other taxane/platinum combinations are possible, although unsubstantiated. Administering the taxane derivative before the platinum derivative seems prudent.
Clarithromycin	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Indinavir	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Itraconazole	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Ketoconazole	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Nefazodone	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Nelfinavir	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Phenobarbital	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Phenytoin	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Rifabutin	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Rifampin	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Rifapentine	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Ritonavir	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Saquinavir	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
St. John's Wort	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Telithromycin	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Voriconazole	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.

Food Interactions

Not Available

Tubulin alpha-1 chain
Name	Tubulin alpha-1 chain
Gene Name	TUBA4A
Pharmacological action	yes
Actions	binder
References	DailyMed: - JEVTANA
DTHybrid score	0.257
Tubulin beta-1 chain
Name	Tubulin beta-1 chain
Gene Name	TUBB1
Pharmacological action	yes
Actions	binder
References	DailyMed: - JEVTANA
DTHybrid score	0.3197

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	DailyMed: - JEVTANA Assessment Report for Jevtana (Cabazitaxel). European Medicines Agency, Committee for Medicinal Products for Human Use. 2011 Jan. -
DTHybrid score	0.6632
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	DailyMed: - JEVTANA Assessment Report for Jevtana (Cabazitaxel). European Medicines Agency, Committee for Medicinal Products for Human Use. 2011 Jan. -
DTHybrid score	0.3636
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	DailyMed: - JEVTANA Assessment Report for Jevtana (Cabazitaxel). European Medicines Agency, Committee for Medicinal Products for Human Use. 2011 Jan. -
DTHybrid score	0.3438

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	DailyMed: - JEVTANA
DTHybrid score	0.5117
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	DailyMed: - JEVTANA
DTHybrid score	0.3248
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	DailyMed: - JEVTANA
DTHybrid score	0.3587
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	inhibitor
References	DailyMed: - JEVTANA
DTHybrid score	0.2833

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.2664
6016	Cytochrome P450 2C19	CYP2C19	0.2349
4119	Cytochrome P450 2D6	CYP2D6	0.2191
6107	Cytochrome P450 3A7	CYP3A7	0.2124
4200	Cytochrome P450 1A2	CYP1A2	0.181
161	Tubulin beta chain	TUBB	0.1622
312	Tubulin beta chain	TUB2	0.1622
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1593
6030	Cytochrome P450 2B6	CYP2B6	0.135
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1311
862	Multidrug resistance-associated protein 1	ABCC1	0.129
587	Serum albumin	ALB	0.1126
2601	Tubulin alpha-2 chain	TUBA3C	0.1086
2480	Tubulin alpha-8 chain	TUBA8	0.1073
2565	Tubulin beta-4 chain	TUBB4	0.1029
2342	Tubulin alpha-ubiquitous chain	TUBA1B	0.1022
2536	Tubulin alpha-6 chain	TUBA1C	0.1021
2444	Tubulin beta-4q chain	TUBB4Q	0.1017
2578	Tubulin beta-3 chain	TUBB3	0.0978
6024	Cytochrome P450 1A1	CYP1A1	0.0955
6013	Cytochrome P450 2E1	CYP2E1	0.0943
2449	Tubulin alpha-3 chain	TUBA1A	0.0853
2499	Tubulin beta-2C chain	TUBB2C	0.0843
776	Bile salt export pump	ABCB11	0.0802
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0714
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0698
1729	Solute carrier family 22 member 6	SLC22A6	0.0689
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0678
6148	Multidrug resistance-associated protein 7	ABCC10	0.0655
6142	Solute carrier family 22 member 8	SLC22A8	0.0645
1898	Cytochrome P450 1B1	CYP1B1	0.0625
5718	Cytochrome P450 2A6	CYP2A6	0.0586
20	Prostaglandin G/H synthase 1	PTGS1	0.0583
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0566
817	DNA topoisomerase 2-alpha	TOP2A	0.0564
6145	Solute carrier family 22 member 1	SLC22A1	0.0542
2164	Multidrug resistance-associated protein 4	ABCC4	0.0532
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0515
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0486
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0465
70	Type-1 angiotensin II receptor	AGTR1	0.0451
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0449
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0449
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0449
6147	Solute carrier family 22 member 3	SLC22A3	0.0445
6143	Solute carrier family 22 member 7	SLC22A7	0.0443
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0434
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0418
3811	Cytochrome P450 19A1	CYP19A1	0.0418
5923	Microtubule-associated protein tau	MAPT	0.0412
5924	Microtubule-associated protein 4	MAP4	0.0412
1852	Microtubule-associated protein 2	MAP2	0.0392
871	Glucocorticoid receptor	NR3C1	0.039
6106	Cytochrome P450 2C18	CYP2C18	0.0389
492	Histamine H1 receptor	HRH1	0.0384
6141	Sodium/bile acid cotransporter	SLC10A1	0.0374
3587	Gastrotropin	FABP6	0.0351
273	Apoptosis regulator Bcl-2	BCL2	0.0349
136	Estrogen receptor	ESR1	0.0349
6144	Solute carrier family 22 member 2	SLC22A2	0.0347
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0314
731	HIV-1 protease	HIV-1 protease	0.0306
824	Sodium-dependent serotonin transporter	SLC6A4	0.03
1024	Solute carrier family 22 member 11	SLC22A11	0.0297
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0292
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0289
844	Epidermal growth factor receptor	EGFR	0.0284
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0266
556	Alpha-1A adrenergic receptor	ADRA1A	0.0263
6138	Multidrug resistance protein 3	ABCB4	0.0263
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0263
847	Mu-type opioid receptor	OPRM1	0.0262
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0261
290	Prostaglandin G/H synthase 2	PTGS2	0.0259
6031	Cytochrome P450 3A43	CYP3A43	0.0249
831	D(2) dopamine receptor	DRD2	0.0245
118	Organic cation/carnitine transporter 2	SLC22A5	0.0243
504	Mast/stem cell growth factor receptor	KIT	0.0238
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0238
4604	Liver carboxylesterase 1	CES1	0.0237
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0235
758	Thyroid hormone receptor alpha	THRA	0.0235
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0233
1353	DNA topoisomerase 1	TOP1	0.0223
3552	DNA topoisomerase 1	topA	0.0223
6182	Cytochrome P450 2J2	CYP2J2	0.0222
467	Delta-type opioid receptor	OPRD1	0.0221
6137	Multidrug resistance-associated protein 6	ABCC6	0.0216
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0215
468	Cytochrome P450 4A11	CYP4A11	0.0215
594	Thyroxine-binding globulin	SERPINA7	0.0211
346	Thyroid hormone receptor beta-1	THRB	0.021
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0209
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0207
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0207
26	Vascular endothelial growth factor receptor 3	FLT4	0.0206
373	Transthyretin	TTR	0.02
696	Kappa-type opioid receptor	OPRK1	0.0199
32	Vascular endothelial growth factor receptor 1	FLT1	0.0198
407	Vascular endothelial growth factor receptor 2	KDR	0.0194
33	Cystine/glutamate transporter	SLC7A11	0.0194
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0194
738	Monocarboxylate transporter 1	SLC16A1	0.0187
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0187
6167	Organic solute transporter subunit beta	OSTB	0.0181
6166	Organic solute transporter subunit alpha	OSTA	0.0181
6136	Multidrug resistance-associated protein 5	ABCC5	0.0179
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0179
632	Alpha-1B adrenergic receptor	ADRA1B	0.0178
833	Organic cation/carnitine transporter 1	SLC22A4	0.0177
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0176
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0176
318	Alpha-2A adrenergic receptor	ADRA2A	0.0175
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0171
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.017
3923	Cholinesterase	BCHE	0.0168
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0167
260	Cytochrome P450 51	ERG11	0.0167
761	Cytochrome P450 51	ERG11	0.0167
3163	Cytochrome P450 51	cyp51	0.0167
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0166
614	Progesterone receptor	PGR	0.0166
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0163
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0162
869	Estrogen receptor beta	ESR2	0.0162
756	Sex hormone-binding globulin	SHBG	0.016
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.016
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.016
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0158
766	Beta-2 adrenergic receptor	ADRB2	0.0158
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0158
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0157
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0156
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0156
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0156
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0156
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0152
23	D(1A) dopamine receptor	DRD1	0.0149
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0148
4120	NADPH--cytochrome P450 reductase	POR	0.0148
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0148
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0147
952	Dipeptidyl peptidase 4	DPP4	0.0146
193	Beta-1 adrenergic receptor	ADRB1	0.0145
6220	Aryl hydrocarbon receptor	AHR	0.0144
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0142
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0141
3941	Amine oxidase [flavin-containing] A	MAOA	0.0139
232	Corticosteroid-binding globulin	SERPINA6	0.0137
117	Sterol O-acyltransferase 1	SOAT1	0.0134
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0134
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0134
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0133
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0133
638	D(3) dopamine receptor	DRD3	0.0132
737	Mineralocorticoid receptor	NR3C2	0.0132
713	Sodium-dependent dopamine transporter	SLC6A3	0.0131
789	Alpha-1D adrenergic receptor	ADRA1D	0.0131
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0129
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
146	Androgen receptor	AR	0.0126
199	Monocarboxylate transporter 8	SLC16A2	0.0125
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0123
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0123
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0122
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0121
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0121
465	Calmodulin	CALM1	0.0118
275	Arachidonate 5-lipoxygenase	ALOX5	0.0114
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0114
5880	Thrombopoietin receptor	MPL	0.0114
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0113
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0111
811	Translocator protein	TSPO	0.0109
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0109
122	P2Y purinoceptor 12	P2RY12	0.0108
4773	Deoxycytidine kinase	DCK	0.0107
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0107
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0105
3856	Fibroblast growth factor receptor 3	FGFR3	0.0105
629	Alpha-2B adrenergic receptor	ADRA2B	0.0103
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0103
3947	Xanthine dehydrogenase/oxidase	XDH	0.0102
818	50S ribosomal protein L10	rplJ	0.0101
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0099
165	FL cytokine receptor	FLT3	0.0098
380	Cytochrome P450 17A1	CYP17A1	0.0098
378	Alpha-2C adrenergic receptor	ADRA2C	0.0098
6020	Aldehyde oxidase	AOX1	0.0097
768	FK506-binding protein 1A	FKBP1A	0.0096
1650	Heme carrier protein 1	SLC46A1	0.0096
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0093
6085	Fatty acid-binding protein, intestinal	FABP2	0.0093
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0092
777	Tumor necrosis factor	TNF	0.0092
3809	Estrogen-related receptor gamma	ESRRG	0.0091
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0091
1192	Sulfotransferase 1A1	SULT1A1	0.0089
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0088
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0088
5787	Angiopoietin-1 receptor	TEK	0.0088
24	Thymidylate synthase	TMP1	0.0087
359	Thymidylate synthase	TYMS	0.0087
2626	Thymidylate synthase	thyA	0.0087
2729	Thymidylate synthase	thyA	0.0087
5352	Thymidylate synthase	THYA	0.0087
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0087
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0086
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0086
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0086
365	Dihydrofolate reductase	DHFR	0.0085
2381	Dihydrofolate reductase	DFR1	0.0085
2833	Dihydrofolate reductase	Not Available	0.0085
2931	Dihydrofolate reductase	folA	0.0085
3544	Dihydrofolate reductase	folA	0.0085
3682	Dihydrofolate reductase	folA	0.0085
6642	Dihydrofolate reductase	folA	0.0085
6756	Dihydrofolate reductase	dfrA	0.0085
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0084
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0084
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0084
239	Coagulation factor X	F10	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
124	Histamine H2 receptor	HRH2	0.0083
6151	Monocarboxylate transporter 10	SLC16A10	0.0082
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0082
469	Annexin A1	ANXA1	0.0081
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0081
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
1757	Myeloperoxidase	MPO	0.0079
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0078
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0078
477	DNA topoisomerase 4 subunit A	parC	0.0078
886	DNA topoisomerase 4 subunit A	parC	0.0078
6226	DNA topoisomerase 4 subunit A	parC	0.0078
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0078
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0077
404	DNA gyrase subunit A	gyrA	0.0077
6224	DNA gyrase subunit A	gyrA	0.0077
904	Glutathione S-transferase P	GSTP1	0.0077
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0077
4237	50S ribosomal protein L22	rplV	0.0076
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0076
284	DNA-directed RNA polymerase beta chain	rpoB	0.0076
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0076
992	Protein tyrosine kinase 2 beta	PTK2B	0.0076
5300	Antigen peptide transporter 1	TAP1	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0074
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0074
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0074
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0074
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0074
474	Acetylcholinesterase	ACHE	0.0073
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0073
908	Glutathione S-transferase theta-1	GSTT1	0.0072
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0072
6149	Solute carrier family 22 member 10	SLC22A10	0.0072
432	D(4) dopamine receptor	DRD4	0.0071
68	Cannabinoid receptor 1	CNR1	0.0071
716	5-hydroxytryptamine 7 receptor	HTR7	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0071
3810	Catechol O-methyltransferase	COMT	0.007
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.007
3939	Amine oxidase [flavin-containing] B	MAOB	0.007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.007
6102	Arylamine N-acetyltransferase 2	NAT2	0.0069
1760	Aminopeptidase N	ANPEP	0.0069
6843	Aminopeptidase N	pepN	0.0069
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0069
244	Angiotensin-converting enzyme	ACE	0.0068
293	Gamma-glutamyl hydrolase	GGH	0.0068
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0067
723	Cytosolic phospholipase A2	PLA2G4A	0.0067
823	Fibroblast growth factor receptor 2	FGFR2	0.0067
1010	Cytochrome P450 51A1	CYP51A1	0.0067
705	Glutamate receptor 1	GRIA1	0.0067
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0067
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0066
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0066
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0063
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0063
4238	50S ribosomal protein L4	rplD	0.0063
5578	50S ribosomal protein L4	rplD	0.0063
6173	50S ribosomal protein L4	rplD	0.0063
6219	50S ribosomal protein L4	rplD	0.0063
4192	DNA topoisomerase 2-beta	TOP2B	0.0062
427	Substance-P receptor	TACR1	0.0062
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0062
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0062
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0062
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0062
1525	Heparin-binding growth factor 2	FGF2	0.0062
1656	CYP2B protein	CYP2B	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.006
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
1618	High affinity nerve growth factor receptor	NTRK1	0.0059
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0059
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
814	Ryanodine receptor 1	RYR1	0.0058
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0057
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0056
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0056
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0056
6146	High affinity copper uptake protein 1	SLC31A1	0.0056
4203	Histamine N-methyltransferase	HNMT	0.0056
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0056
4122	Histone deacetylase 2	HDAC2	0.0055
1630	Integrin beta-2	ITGB2	0.0055
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0055
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0055
936	Ephrin type-A receptor 2	EPHA2	0.0055
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0054
3932	Glutathione S-transferase A2	GSTA2	0.0054
6824	Tyrosine-protein kinase Lyn	LYN	0.0054
3086	Plasmepsin-2	Not Available	0.0053
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0053
2112	Toll-like receptor 9	TLR9	0.0053
5818	Folate receptor alpha	FOLR1	0.0052
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0052
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0052
88	Retinoic acid receptor RXR-beta	RXRB	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
94	5-hydroxytryptamine 4 receptor	HTR4	0.0051
461	Glycine receptor subunit alpha-3	GLRA3	0.0051
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0051
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.005
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.005
319	Opioid receptor, sigma 1	OPRS1	0.0049
1541	Metalloproteinase	mmp20	0.0049
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0049
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0049
6014	Cytochrome P450 2A13	CYP2A13	0.0048
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0048
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0048
6174	50S ribosomal protein L32	rpmF	0.0047
1178	Adenosine A2a receptor	ADORA2A	0.0047
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0047
2216	Fibroblast growth factor receptor 4	FGFR4	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0046
84	Nuclear receptor 0B1	NR0B1	0.0046
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0045
6163	Copper-transporting ATPase 2	ATP7B	0.0045
6165	Copper-transporting ATPase 1	ATP7A	0.0045
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0045
896	Glutathione S-transferase Mu 1	GSTM1	0.0045
6044	Serum paraoxonase/lactonase 3	PON3	0.0045
54	Prothrombin	F2	0.0045
1483	Membrane copper amine oxidase	AOC3	0.0045
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0045
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0044
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0044
563	Thyroid peroxidase	TPO	0.0044
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0044
2599	Tyrosine-protein kinase HCK	HCK	0.0044
760	Fibroblast growth factor 1	FGF1	0.0044
1629	Transcription factor AP-1	JUN	0.0044
1050	Bile salt sulfotransferase	SULT2A1	0.0044
106	Cannabinoid receptor 2	CNR2	0.0044
856	Vitamin D3 receptor	VDR	0.0043
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0043
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0043
891	Dihydropteroate synthase	folP	0.0043
5359	Dihydropteroate synthase	folP	0.0043
7175	Dihydropteroate synthase	sulI	0.0043
4311	tRNA	TRDMT1	0.0043
4325	tRNA	trmD	0.0043
4328	tRNA	trmD	0.0043
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0042
2391	Ferrochelatase	hemH	0.0042
6502	Ferrochelatase	DKFZp686P18130	0.0042
1591	Ferrochelatase, mitochondrial	FECH	0.0042
572	Integrin alpha-L	ITGAL	0.0042
162	Retinoic acid receptor gamma-1	RARG	0.0042
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
6168	Solute carrier family 22 member 16	SLC22A16	0.0041
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0041
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0041
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
528	5-hydroxytryptamine 1E receptor	HTR1E	0.004
295	Carbonic anhydrase 1	CA1	0.0039
16	Adenosine A1 receptor	ADORA1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
183	Vascular endothelial growth factor A	VEGFA	0.0038
163	D(1B) dopamine receptor	DRD5	0.0038
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0037
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0037
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0037
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0037
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0037
4103	Proteasome subunit beta type 2	PSMB2	0.0037
4102	Proteasome subunit beta type 5	PSMB5	0.0037
4101	Proteasome subunit beta type 1	PSMB1	0.0037
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0037
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0037
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0037
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0037
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0037
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0037
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0037
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0037
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0037
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0037
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0037
6559	Cytochrome c oxidase subunit 2	ctaC	0.0037
6669	Cytochrome c oxidase subunit 2	ctaC	0.0037
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0037
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0037
6558	Cytochrome c oxidase subunit 1	ctaD	0.0037
4217	Telomerase reverse transcriptase	TERT	0.0036
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0036
1196	Complement decay-accelerating factor	CD55	0.0036
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0036
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0035
267	Plasminogen activator inhibitor 1	SERPINE1	0.0035
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
4116	Dihydropteroate synthetase	Not Available	0.0035
6837	Serine/threonine-protein kinase 17B	STK17B	0.0035
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0035
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0035
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0035
939	50S ribosomal protein L3	rplC	0.0035
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0034
131	Synaptic vesicular amine transporter	SLC18A2	0.0034
484	Tyrosine-protein kinase ABL2	ABL2	0.0034
2540	Choloylglycine hydrolase	cbh	0.0034
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0033
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0033
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0033
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
780	Retinoic acid receptor RXR-gamma	RXRG	0.0033
1517	Beta-3 adrenergic receptor	ADRB3	0.0033
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
6221	Steroid hormone receptor ERR1	ESRRA	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
229	Retinoic acid receptor beta	RARB	0.0032
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0032
7	Nitric oxide synthase, inducible	NOS2	0.0032
2808	Chloramphenicol acetyltransferase 3	cat3	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
6501	Fatty acid-binding protein, liver	FABP1	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
153	Dopamine beta-hydroxylase	DBH	0.0031
730	Retinoic acid receptor alpha	RARA	0.0031
1648	Elastin	ELN	0.0031
921	Glutamate receptor 2	GRIA2	0.0031
976	Platelet glycoprotein IX	GP9	0.0031
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
702	UMP-CMP kinase	CMPK1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
5798	Mitogen-activated protein kinase 11	MAPK11	0.0029
489	Monocarboxylate transporter 2	SLC16A7	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0029
2320	Thymidine kinase, cytosolic	TK1	0.0029
2417	Chloramphenicol acetyltransferase	cat	0.0029
3278	Chloramphenicol acetyltransferase	cat	0.0029
3601	Dihydropteroate synthase 1	folP1	0.0029
3807	Dihydropteroate synthase 1	folP1	0.0029
3808	Dihydropteroate synthase 2	folP2	0.0029
2810	Dr hemagglutinin structural subunit	draA	0.0029
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0028
751	Potassium channel subfamily K member 6	KCNK6	0.0028
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0028
1291	cAMP response element-binding protein	CREB1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
1864	RET proto-oncogene	RET	0.0028
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0028
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0028
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0028
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
174	Sigma 1-type opioid receptor	SIGMAR1	0.0027
4210	Toll-like receptor 4	TLR4	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0027
3913	Glutamic acid decarboxylase	GAD65	0.0027
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0027
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0027
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0026
6048	Troponin C, skeletal muscle	TNNC2	0.0026
172	Potassium channel subfamily K member 1	KCNK1	0.0026
4226	Uridine phosphorylase 2	UPP2	0.0026
6500	Phospholipase A2	PLA2G1B	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
581	Cytochrome P450 2R1	CYP2R1	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
49	Endothelin B receptor	EDNRB	0.0026
605	Fumarate reductase flavoprotein subunit	frdA	0.0026
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0026
3673	Fumarate reductase flavoprotein subunit	fccA	0.0026
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0026
6549	Fumarate reductase flavoprotein subunit	frdA	0.0026
517	Alcohol dehydrogenase 1C	ADH1C	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
551	Carnitine O-acetyltransferase	CRAT	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0025
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
6103	Arylamine N-acetyltransferase 1	NAT1	0.0025
4225	Uridine phosphorylase 1	UPP1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0024
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
357	Carbonic anhydrase 2	CA2	0.0024
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0024
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0024
3955	Cell division protein kinase 6	CDK6	0.0023
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0023
6228	Nuclear receptor coactivator 1	NCOA1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
518	Peroxidase/catalase T	katG	0.0023
6241	Nuclear receptor coactivator 2	NCOA2	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0023
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0023
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
735	Alanine aminotransferase 1	GPT	0.0023
3904	Alanine aminotransferase 2	GPT2	0.0023
413	Amidophosphoribosyltransferase	PPAT	0.0022
2515	Amidophosphoribosyltransferase	purF	0.0022
3714	Amidophosphoribosyltransferase	purF	0.0022
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0022
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0022
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0022
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0022
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
558	Solute carrier family 12 member 1	SLC12A1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0021
6432	Transporter	snf	0.002
719	Retinoic acid receptor responder protein 1	RARRES1	0.002
770	Retinoic acid-induced protein 3	GPRC5A	0.002
5934	Cytochrome P450 26A1	CYP26A1	0.002
5626	Nucleoside diphosphate kinase B	NME2	0.002
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.002
6459	Glycodelin	PAEP	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
132	ATP-binding cassette sub-family A member 1	ABCA1	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
634	Squalene monooxygenase	SQLE	0.0019
7196	Squalene monooxygenase	ERG1	0.0019
3639	Thymidine phosphorylase	deoA	0.0019
3936	Thymidine phosphorylase	TYMP	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
569	Retinal dehydrogenase 2	ALDH1A2	0.0018
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0017
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
3957	Adenosine deaminase	ADA	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
5294	Nucleoside diphosphate kinase A	NME1	0.0017
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
611	Retinal dehydrogenase 1	ALDH1A1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0016
173	Toll-like receptor 7	TLR7	0.0016
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0016
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0016
1039	Histone deacetylase 9	HDAC9	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6755	Poliovirus receptor	PVR	0.0015
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0015
1992	Vitamin D-binding protein	GC	0.0015
6033	High affinity interleukin-8 receptor A	CXCR1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0014
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
2207	Rhodopsin	RHO	0.0014
1275	Estrogen sulfotransferase	SULT1E1	0.0014
291	Nitric-oxide synthase, endothelial	NOS3	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0014
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0014
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
6218	Pannexin-1	PANX1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0013
164	Histamine H4 receptor	HRH4	0.0013
2021	Thrombomodulin	THBD	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3937	Fatty-acid amide hydrolase	FAAH	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
76	Nitric-oxide synthase, brain	NOS1	0.0012
1295	Fatty acid synthase	FASN	0.0012
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0012
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0012
6859	Protein S100-A4	S100A4	0.0012
268	Adenosine A2b receptor	ADORA2B	0.0012
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0011
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0011
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0011
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1792	Tissue-type plasminogen activator	PLAT	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2298	Cytochrome P450-cam	camC	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
3221	Cytochrome c4	cc4	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4943	Cytochrome c6	petJ	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4961	Hemophore HasA	hasA	0.0003
4909	CooA protein	cooA	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
5000	HemO	hemO	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4910	Cytoglobin	CYGB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4972	P450cin	cinA	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
4920	Peroxidase/catalase	katG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
4948	Cytochrome c-553	Not Available	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4923	Cytochrome c3	DvMF_2499	0.0002
4945	Cytochrome c3	Not Available	0.0002
4949	Cytochrome c3	DVU_3171	0.0002
4968	Cytochrome c3	cytc3	0.0002
4997	Cytochrome c3	SO_2727	0.0002
5219	Cytochrome c3	cyd	0.0002
4902	Nine-heme cytochrome c	Ddes_2038	0.0002
3189	High-molecular-weight cytochrome c	hmcA	0.0002
6021	Adenosine kinase	ADK	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
4386	Hemoglobin-like protein HbN	glbN	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB06772 - Cabazitaxel

Targets

Enzymes

Transporters

Predictions