DT-Web

DB00515 - Cisplatin


Identification
Name Cisplatin
Accession Number DB00515 (APRD00359)
Type small molecule
Description Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 298.035
Groups approved
Monoisotopic Weight 296.939928001
Pharmacology
Indication For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Mechanism of action Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Absorption Following cisplatin doses of 20 to 120 mg/m^2, the concentrations of platinum are highest in liver, prostate, and kidney; somewhat lower in bladder, muscle, testicle, pancreas, and spleen; and lowest in bowel, adrenal, heart, lung, cerebrum, and cerebellum. Platinum is present in tissues for as long as 180 days after the last administration.
Protein binding Cisplatin does not undergo instantaneous and reversible binding to plasma protein that is characteristic of normal drug-protein binding. However, the platinum itself is capable of binding to plasma proteins, including albumin, transferrin, and gamma globulin. Three hours after a bolus injection and two hours after the end of a three-hour infusion, 90% of the plasma platinum is protein bound.
Biotransformation Not Available
Route of elimination The parent compound, cisplatin, is excreted in the urine. Although small amounts of platinum are present in the bile and large intestine after administration of cisplatin, the fecal excretion of platinum appears to be insignificant.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin Increased risk of nephrotoxicity
Bendamustine Increases toxicity through pharmacodynamic synergism. Additive myelosuppression.
Bumetanide Increased ototoxicity
Cabazitaxel Platinum derivatives such as cisplatin may enhance the myelosuppressive effect of taxane derivatives such as cabazitaxel. Administer taxane derivative before platinum derivative when given as sequential infusions to limit toxicity.Administer paclitaxel before cisplatin, when given as sequential infusions, to limit toxicity. Problems associated with other taxane/platinum combinations are possible, although unsubstantiated. Administering the taxane derivative before the platinum derivative seems prudent.
Docetaxel Platinum derivatives such as cisplatin may enhance the myelosuppressive effect of taxane derivatives such as docetaxel. Administer taxane derivative before platinum derivative when given as sequential infusions to limit toxicity. Administer paclitaxel before cisplatin, when given as sequential infusions, to limit toxicity. Problems associated with other taxane/platinum combinations are possible, although unsubstantiated. Administering the taxane derivative before the platinum derivative seems prudent.
Ethacrynic acid Increased ototoxicity
Fosphenytoin The antineoplasic agent decreases the effect of hydantoin
Furosemide Increased ototoxicity
Gentamicin Increased risk of nephrotoxicity
Leflunomide Immunosuppressants such as cisplatin may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Methotrexate Cisplatin increases methotrexate toxicity
Natalizumab Immunosuppressants such as cisplatin may enhance the adverse/toxic effect of natalizumab. Specifically, the risk of concurrent infection may be increased. Patients receiving natalizumab should not use concurrent immunosuppressants, and patients receiving chronic corticosteroids prior to natalizumab should be tapered off of steroids prior to starting natalizumab.
Netilmicin Increased risk of nephrotoxicity
Paclitaxel Cisplatin increases the effect and toxicity of paclitaxel
Phenytoin The antineoplasic agent decreases the effect of hydantoin
Pimecrolimus Pimecrolimus may enhance the adverse/toxic effect of immunosuppressants such as cisplatin. Avoid use of pimecrolimus cream in patients receiving immunosuppressants.
Roflumilast Roflumilast may enhance the immunosuppressive effect of immunosuppressants such as cisplatin. The Canadian roflumilast product monograph recommends avoiding concurrent use of roflumilast with any immunosuppressant medications due to the antiinflammatory/immune altering effects of roflumilast and the lack of relevant clinical experience with such use. Of note, this recommendation to avoid concurrent use does not apply to either inhaled corticosteroids (which have much more limited systemic immune-suppressing actions) or short-term systemic corticosteroid use. U.S. prescribing information does not contain this warning; but it appears prudent to avoid this combination when possible.
Tacrolimus Additive renal impairment may occur during concomitant therapy with aminoglycosides such as Cisplatin. Use caution during concomitant therapy.
Tobramycin Increased risk of nephrotoxicity
Topotecan Administration of Topotecan after Cisplatin therapy may increase the risk of hematologic toxicity, such as neutropenia and/or thrombocytopenia. A dose adjustment may be required or the sequence of administration reversed.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Food Interactions
  • Echinacea should be used with caution, if at all, in patients receiving therapeutic immunosuppressants. Monitor for reduced efficacy of the immunosuppressant during concomitant use.

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions cross-linking/alkylation
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Garcia Sar D, Montes-Bayon M, Aguado Ortiz L, Blanco-Gonzalez E, Sierra LM, Sanz-Medel A: In vivo detection of DNA adducts induced by cisplatin using capillary HPLC-ICP-MS and their correlation with genotoxic damage in Drosophila melanogaster. Anal Bioanal Chem. 2007 Oct 12;. - Pubmed
  • Sharma S, Gong P, Temple B, Bhattacharyya D, Dokholyan NV, Chaney SG: Molecular Dynamic Simulations of Cisplatin- and Oxaliplatin-d(GG) Intrastand Cross-links Reveal Differences in their Conformational Dynamics. J Mol Biol. 2007 Aug 23;. - Pubmed
  • Bloemink MJ, Reedijk J: Cisplatin and derived anticancer drugs: mechanism and current status of DNA binding. Met Ions Biol Syst. 1996;32:641-85. - Pubmed
DTHybrid score Not Available

Enzymes


Myeloperoxidase
Name Myeloperoxidase
Gene Name MPO
Actions inducer
References
  • Erdogan S, Tosyali E, Duzguner V, Kucukgul A, Aslantas O, Celik S: Cisplatin reduces Brucella melitensis-infected cell number by inducing apoptosis, oxidant and pro-inflammatory cytokine production. Res Vet Sci. 2010 Apr;88(2):218-26. Epub 2009 Oct 8. - Pubmed
  • Ozen S, Akyol O, Iraz M, Sogut S, Ozugurlu F, Ozyurt H, Odaci E, Yildirim Z: Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats. J Appl Toxicol. 2004 Jan-Feb;24(1):27-35. - Pubmed
DTHybrid score 0.6185
Xanthine dehydrogenase/oxidase
Name Xanthine dehydrogenase/oxidase
Gene Name XDH
Actions inducer
References
  • Yilmaz HR, Sogut S, Ozyurt B, Ozugurlu F, Sahin S, Isik B, Uz E, Ozyurt H: The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester. Toxicol Ind Health. 2005 May;21(3-4):67-73. - Pubmed
  • Cetin R, Devrim E, Kilicoglu B, Avci A, Candir O, Durak I: Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods. J Appl Toxicol. 2006 Jan-Feb;26(1):42-6. - Pubmed
  • Erdogan S, Tosyali E, Duzguner V, Kucukgul A, Aslantas O, Celik S: Cisplatin reduces Brucella melitensis-infected cell number by inducing apoptosis, oxidant and pro-inflammatory cytokine production. Res Vet Sci. 2010 Apr;88(2):218-26. Epub 2009 Oct 8. - Pubmed
DTHybrid score 0.6659
Cytochrome P450 4A11
Name Cytochrome P450 4A11
Gene Name CYP4A11
Actions inducer
References
  • Nakamura M, Imaoka S, Tanaka E, Misawa S, Funae Y: cis-Diamminedichloroplatinum induces peroxisomes as well as CYP4A1 in rat kidney. Res Commun Mol Pathol Pharmacol. 1998 Jan;99(1):23-32. - Pubmed
DTHybrid score 0.2203
Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Actions inhibitor
References
  • Tusgaard B, Norregaard R, Jensen AM, Wang G, Topcu SO, Wang Y, Nielsen S, Frokiaer J: Cisplatin decreases renal cyclooxygenase-2 expression and activity in rats. Acta Physiol (Oxf). 2011 May;202(1):79-90. doi: 10.1111/j.1748-1716.2011.02257.x. Epub 2011 Mar 22. - Pubmed
DTHybrid score 0.5364
Arylamine N-acetyltransferase
Name Arylamine N-acetyltransferase
Gene Name nat
Actions inhibitor
References
  • Ragunathan N, Dairou J, Pluvinage B, Martins M, Petit E, Janel N, Dupret JM, Rodrigues-Lima F: Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: molecular and cellular mechanisms of inhibition. Mol Pharmacol. 2008 Jun;73(6):1761-8. Epub 2008 Feb 29. - Pubmed
  • Holzer AK, Samimi G, Katano K, Naerdemann W, Lin X, Safaei R, Howell SB: The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells. Mol Pharmacol. 2004 Oct;66(4):817-23. Epub 2004 Jun 30. - Pubmed
  • Holzer AK, Samimi G, Katano K, Naerdemann W, Lin X, Safaei R, Howell SB: The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells. Mol Pharmacol. 2004 Oct;66(4):817-23. Epub 2004 Jun 30. - Pubmed
  • Holzer AK, Samimi G, Katano K, Naerdemann W, Lin X, Safaei R, Howell SB: The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells. Mol Pharmacol. 2004 Oct;66(4):817-23. Epub 2004 Jun 30. - Pubmed
  • Holzer AK, Samimi G, Katano K, Naerdemann W, Lin X, Safaei R, Howell SB: The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells. Mol Pharmacol. 2004 Oct;66(4):817-23. Epub 2004 Jun 30. - Pubmed
DTHybrid score Not Available
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Masek V, Anzenbacherova E, Machova M, Brabec V, Anzenbacher P: Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450. Anticancer Drugs. 2009 Jun;20(5):305-11. - Pubmed
DTHybrid score 0.5086
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Masek V, Anzenbacherova E, Machova M, Brabec V, Anzenbacher P: Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450. Anticancer Drugs. 2009 Jun;20(5):305-11. - Pubmed
DTHybrid score 0.3691
Cholinesterase
Name Cholinesterase
Gene Name BCHE
Actions inhibitor
References
  • Bodur E: Human serum butyrylcholinesterase interactions with cisplatin and cyclophosphamide. Biochimie. 2010 Aug;92(8):979-84. Epub 2010 Apr 24. - Pubmed
DTHybrid score 0.6756
Glutathione S-transferase theta-1
Name Glutathione S-transferase theta-1
Gene Name GSTT1
Actions substrate
References
  • Peters U, Preisler-Adams S, Hebeisen A, Hahn M, Seifert E, Lanvers C, Heinecke A, Horst J, Jurgens H, Lamprecht-Dinnesen A: Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs. 2000 Sep;11(8):639-43. - Pubmed
DTHybrid score 0.4669
Metallothionein-1A
Name Metallothionein-1A
Gene Name Not Available
Actions substrate
References
  • Meijer C, Timmer A, De Vries EG, Groten JP, Knol A, Zwart N, Dam WA, Sleijfer DT, Mulder NH: Role of metallothionein in cisplatin sensitivity of germ-cell tumours. Int J Cancer. 2000 Mar 15;85(6):777-81. - Pubmed
DTHybrid score Not Available
Metallothionein-2
Name Metallothionein-2
Gene Name Not Available
Actions substrate
References
  • Meijer C, Timmer A, De Vries EG, Groten JP, Knol A, Zwart N, Dam WA, Sleijfer DT, Mulder NH: Role of metallothionein in cisplatin sensitivity of germ-cell tumours. Int J Cancer. 2000 Mar 15;85(6):777-81. - Pubmed
DTHybrid score Not Available
Superoxide dismutase [Cu-Zn]
Name Superoxide dismutase [Cu-Zn]
Gene Name SOD1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.4885
Glutathione S-transferase P
Name Glutathione S-transferase P
Gene Name GSTP1
Actions substrate
References
  • Peters U, Preisler-Adams S, Hebeisen A, Hahn M, Seifert E, Lanvers C, Heinecke A, Horst J, Jurgens H, Lamprecht-Dinnesen A: Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs. 2000 Sep;11(8):639-43. - Pubmed
DTHybrid score 0.9541
NAD(P)H dehydrogenase [quinone] 1
Name NAD(P)H dehydrogenase [quinone] 1
Gene Name NQO1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 1.0902
Glutathione S-transferase Mu 1
Name Glutathione S-transferase Mu 1
Gene Name GSTM1
Actions substrate
References
  • Peters U, Preisler-Adams S, Hebeisen A, Hahn M, Seifert E, Lanvers C, Heinecke A, Horst J, Jurgens H, Lamprecht-Dinnesen A: Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs. 2000 Sep;11(8):639-43. - Pubmed
DTHybrid score 0.9372

Transporters


Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions inducer
References
  • Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. - Pubmed
DTHybrid score 0.2879
Multidrug resistance-associated protein 5
Name Multidrug resistance-associated protein 5
Gene Name ABCC5
Actions inducer
References
  • Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. - Pubmed
DTHybrid score 0.2481
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inducer
References
  • Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. - Pubmed
  • Demeule M, Brossard M, Beliveau R: Cisplatin induces renal expression of P-glycoprotein and canalicular multispecific organic anion transporter. Am J Physiol. 1999 Dec;277(6 Pt 2):F832-40. - Pubmed
DTHybrid score 0.5475
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate,inhibitor
References
  • Pan BF, Sweet DH, Pritchard JB, Chen R, Nelson JA: A transfected cell model for the renal toxin transporter, rOCT2. Toxicol Sci. 1999 Feb;47(2):181-6. - Pubmed
  • Burger H, Zoumaro-Djayoon A, Boersma AW, Helleman J, Berns EM, Mathijssen RH, Loos WJ, Wiemer EA: Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2). Br J Pharmacol. 2010 Feb;159(4):898-908. Epub 2010 Jan 8. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.328
High affinity copper uptake protein 1
Name High affinity copper uptake protein 1
Gene Name SLC31A1
Actions substrate
References
  • Howell SB, Safaei R, Larson CA, Sailor MJ: Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs. Mol Pharmacol. 2010 Jun;77(6):887-94. Epub 2010 Feb 16. - Pubmed
  • Kurokawa T, He G, Siddik ZH: Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner. Cancer Chemother Pharmacol. 2010 Feb;65(3):427-36. Epub 2009 Jun 16. - Pubmed
  • Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, Howell SB: Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. Clin Cancer Res. 2009 Jan 15;15(2):553-60. - Pubmed
  • Liang ZD, Stockton D, Savaraj N, Tien Kuo M: Mechanistic comparison of human high-affinity copper transporter 1-mediated transport between copper ion and cisplatin. Mol Pharmacol. 2009 Oct;76(4):843-53. Epub 2009 Jul 1. - Pubmed
  • Rabik CA, Maryon EB, Kasza K, Shafer JT, Bartnik CM, Dolan ME: Role of copper transporters in resistance to platinating agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):133-42. Epub 2008 Nov 8. - Pubmed
  • Pabla N, Murphy RF, Liu K, Dong Z: The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. Am J Physiol Renal Physiol. 2009 Mar;296(3):F505-11. Epub 2009 Jan 14. - Pubmed
  • Furukawa T, Komatsu M, Ikeda R, Tsujikawa K, Akiyama S: Copper transport systems are involved in multidrug resistance and drug transport. Curr Med Chem. 2008;15(30):3268-78. - Pubmed
  • Holzer, A.K. et al. The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells. Mol Pharmacol 66, 817-823 (2004). - Pubmed
DTHybrid score 0.4763
Probable low affinity copper uptake protein 2
Name Probable low affinity copper uptake protein 2
Gene Name SLC31A2
Actions substrate
References
  • Blair BG, Larson CA, Safaei R, Howell SB: Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin. Clin Cancer Res. 2009 Jul 1;15(13):4312-21. Epub 2009 Jun 9. - Pubmed
DTHybrid score 0.4082
Multidrug resistance-associated protein 6
Name Multidrug resistance-associated protein 6
Gene Name ABCC6
Actions substrate
References
  • Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD: Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. - Pubmed
DTHybrid score 0.2813
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Li D, Jang SH, Kim J, Wientjes MG, Au JL: Enhanced drug-induced apoptosis associated with P-glycoprotein overexpression is specific to antimicrotubule agents. Pharm Res. 2003 Jan;20(1):45-50. - Pubmed
DTHybrid score 0.5667
Copper-transporting ATPase 2
Name Copper-transporting ATPase 2
Gene Name ATP7B
Actions substrate
References
  • Rabik CA, Maryon EB, Kasza K, Shafer JT, Bartnik CM, Dolan ME: Role of copper transporters in resistance to platinating agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):133-42. Epub 2008 Nov 8. - Pubmed
  • Mangala LS, Zuzel V, Schmandt R, Leshane ES, Halder JB, Armaiz-Pena GN, Spannuth WA, Tanaka T, Shahzad MM, Lin YG, Nick AM, Danes CG, Lee JW, Jennings NB, Vivas-Mejia PE, Wolf JK, Coleman RL, Siddik ZH, Lopez-Berestein G, Lutsenko S, Sood AK: Therapeutic Targeting of ATP7B in Ovarian Carcinoma. Clin Cancer Res. 2009 Jun 1;15(11):3770-80. Epub 2009 May 26. - Pubmed
  • Furukawa T, Komatsu M, Ikeda R, Tsujikawa K, Akiyama S: Copper transport systems are involved in multidrug resistance and drug transport. Curr Med Chem. 2008;15(30):3268-78. - Pubmed
DTHybrid score 0.4952
Copper-transporting ATPase 1
Name Copper-transporting ATPase 1
Gene Name ATP7A
Actions substrate
References
  • Rabik CA, Maryon EB, Kasza K, Shafer JT, Bartnik CM, Dolan ME: Role of copper transporters in resistance to platinating agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):133-42. Epub 2008 Nov 8. - Pubmed
  • Furukawa T, Komatsu M, Ikeda R, Tsujikawa K, Akiyama S: Copper transport systems are involved in multidrug resistance and drug transport. Curr Med Chem. 2008;15(30):3268-78. - Pubmed
DTHybrid score 0.4952
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F: Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP. Toxicol In Vitro. 2008 Dec;22(8):1846-52. doi: 10.1016/j.tiv.2008.09.001. Epub 2008 Sep 9. - Pubmed
DTHybrid score 0.5422

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.4663
4200 Cytochrome P450 1A2 CYP1A2 0.327
6016 Cytochrome P450 2C19 CYP2C19 0.2924
20 Prostaglandin G/H synthase 1 PTGS1 0.2899
4924 Cytochrome P450 2C8 CYP2C8 0.2728
4119 Cytochrome P450 2D6 CYP2D6 0.2452
6013 Cytochrome P450 2E1 CYP2E1 0.2144
4118 Cytochrome P450 3A5 CYP3A5 0.2091
862 Multidrug resistance-associated protein 1 ABCC1 0.2048
6024 Cytochrome P450 1A1 CYP1A1 0.2032
6145 Solute carrier family 22 member 1 SLC22A1 0.1821
2164 Multidrug resistance-associated protein 4 ABCC4 0.1805
1898 Cytochrome P450 1B1 CYP1B1 0.1694
6147 Solute carrier family 22 member 3 SLC22A3 0.1338
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1325
6107 Cytochrome P450 3A7 CYP3A7 0.13
587 Serum albumin ALB 0.1282
1729 Solute carrier family 22 member 6 SLC22A6 0.1252
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1217
4031 Glutathione S-transferase A1 GSTA1 0.1194
6142 Solute carrier family 22 member 8 SLC22A8 0.1182
5718 Cytochrome P450 2A6 CYP2A6 0.1135
776 Bile salt export pump ABCB11 0.1067
474 Acetylcholinesterase ACHE 0.1052
3932 Glutathione S-transferase A2 GSTA2 0.1022
2165 Glutathione S-transferase Mu 2 GSTM2 0.0987
118 Organic cation/carnitine transporter 2 SLC22A5 0.0924
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0891
6148 Multidrug resistance-associated protein 7 ABCC10 0.0871
6143 Solute carrier family 22 member 7 SLC22A7 0.0869
817 DNA topoisomerase 2-alpha TOP2A 0.0837
6106 Cytochrome P450 2C18 CYP2C18 0.0769
275 Arachidonate 5-lipoxygenase ALOX5 0.0764
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.07
6020 Aldehyde oxidase AOX1 0.0697
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0642
1181 Alpha-1-acid glycoprotein 1 ORM1 0.061
2314 Triosephosphate isomerase TPI 0.0595
3417 Triosephosphate isomerase tpiA 0.0595
3443 Triosephosphate isomerase tpiA 0.0595
6346 Triosephosphate isomerase TPI1 0.0595
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0593
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0586
1024 Solute carrier family 22 member 11 SLC22A11 0.0585
4041 Microsomal glutathione S-transferase 2 MGST2 0.0543
901 Glutathione S-transferase Mu 4 GSTM4 0.0538
3811 Cytochrome P450 19A1 CYP19A1 0.0533
766 Beta-2 adrenergic receptor ADRB2 0.0515
617 Muscarinic acetylcholine receptor M2 CHRM2 0.05
833 Organic cation/carnitine transporter 1 SLC22A4 0.0488
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0482
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0475
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0469
6141 Sodium/bile acid cotransporter SLC10A1 0.0465
4192 DNA topoisomerase 2-beta TOP2B 0.0457
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0456
5241 Probable thiol peroxidase tpx 0.0454
5239 Exopolyphosphatase ppx 0.0453
4440 NADH peroxidase npr 0.0451
4407 FMN-dependent NADH-azoreductase azoR 0.045
5169 FMN-dependent NADH-azoreductase azoR 0.045
1405 Thiopurine S-methyltransferase TPMT 0.0448
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0444
136 Estrogen receptor ESR1 0.0423
4120 NADPH--cytochrome P450 reductase POR 0.0423
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0417
556 Alpha-1A adrenergic receptor ADRA1A 0.0415
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0399
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0398
899 Glutathione S-transferase Mu 3 GSTM3 0.0397
905 Glutathione transferase omega-1 GSTO1 0.0394
2750 Aspartate 1-decarboxylase panD 0.0394
723 Cytosolic phospholipase A2 PLA2G4A 0.039
238 Peroxisome proliferator-activated receptor gamma PPARG 0.039
824 Sodium-dependent serotonin transporter SLC6A4 0.0379
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0378
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0376
1313 Lactoylglutathione lyase GLO1 0.0371
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.036
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0356
492 Histamine H1 receptor HRH1 0.0355
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0353
713 Sodium-dependent dopamine transporter SLC6A3 0.0349
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0348
831 D(2) dopamine receptor DRD2 0.0347
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0341
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0338
4604 Liver carboxylesterase 1 CES1 0.0328
465 Calmodulin CALM1 0.0328
3759 Glutathione S-transferase gst 0.0325
4541 Glutathione S-transferase GST 0.0325
2159 Quinone oxidoreductase CRYZ 0.0324
6085 Fatty acid-binding protein, intestinal FABP2 0.0323
85 Growth hormone receptor GHR 0.0319
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0316
1736 Somatostatin SST 0.0311
4186 Neuropeptide Y receptor type 2 NPY2R 0.0311
3873 Prolyl endopeptidase PREP 0.031
6928 Prolyl endopeptidase Not Available 0.031
24 Thymidylate synthase TMP1 0.0306
359 Thymidylate synthase TYMS 0.0306
2626 Thymidylate synthase thyA 0.0306
2729 Thymidylate synthase thyA 0.0306
5352 Thymidylate synthase THYA 0.0306
738 Monocarboxylate transporter 1 SLC16A1 0.0294
6168 Solute carrier family 22 member 16 SLC22A16 0.0293
54 Prothrombin F2 0.0292
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0287
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0286
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0286
70 Type-1 angiotensin II receptor AGTR1 0.0285
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0285
86 SEC14-like protein 4 SEC14L4 0.0284
375 SEC14-like protein 3 SEC14L3 0.0284
4076 Diacylglycerol kinase alpha DGKA 0.0284
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0283
7 Nitric oxide synthase, inducible NOS2 0.0281
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.028
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.028
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.028
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0279
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0277
153 Dopamine beta-hydroxylase DBH 0.0275
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0274
193 Beta-1 adrenergic receptor ADRB1 0.027
239 Coagulation factor X F10 0.0269
1656 CYP2B protein CYP2B 0.0269
283 SEC14-like protein 2 SEC14L2 0.0268
563 Thyroid peroxidase TPO 0.0267
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0266
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0265
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0265
708 Alpha-tocopherol transfer protein TTPA 0.0261
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0261
161 Tubulin beta chain TUBB 0.0257
312 Tubulin beta chain TUB2 0.0257
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0256
309 Antithrombin-III SERPINC1 0.0256
3917 Methylenetetrahydrofolate reductase MTHFR 0.0255
124 Histamine H2 receptor HRH2 0.0249
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0246
997 Protein kinase C beta type PRKCB 0.0245
5626 Nucleoside diphosphate kinase B NME2 0.0245
502 5-hydroxytryptamine 2A receptor HTR2A 0.0243
6220 Aryl hydrocarbon receptor AHR 0.0242
3941 Amine oxidase [flavin-containing] A MAOA 0.0241
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.024
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0239
341 5-hydroxytryptamine 3 receptor HTR3A 0.0236
3866 Serum amyloid A protein SAA1 0.0236
3939 Amine oxidase [flavin-containing] B MAOB 0.0236
1932 Apolipoprotein E APOE 0.0236
1200 AMBP protein AMBP 0.0236
122 P2Y purinoceptor 12 P2RY12 0.0233
6149 Solute carrier family 22 member 10 SLC22A10 0.0231
731 HIV-1 protease HIV-1 protease 0.023
4103 Proteasome subunit beta type 2 PSMB2 0.023
4101 Proteasome subunit beta type 1 PSMB1 0.023
4102 Proteasome subunit beta type 5 PSMB5 0.023
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0228
871 Glucocorticoid receptor NR3C1 0.0227
1353 DNA topoisomerase 1 TOP1 0.0225
3552 DNA topoisomerase 1 topA 0.0225
1970 Protein kinase C alpha type PRKCA 0.0223
146 Androgen receptor AR 0.0222
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0221
504 Mast/stem cell growth factor receptor KIT 0.0218
810 Heme oxygenase 1 HMOX1 0.0216
3391 Heme oxygenase 1 pbsA1 0.0216
6012 Tryptophan 2,3-dioxygenase TDO2 0.0216
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0216
318 Alpha-2A adrenergic receptor ADRA2A 0.0216
503 Somatostatin receptor type 1 SSTR1 0.0214
6031 Cytochrome P450 3A43 CYP3A43 0.0214
2433 Capsid protein P40 UL80 0.0213
3569 Capsid protein P40 BVRF2 0.0213
614 Progesterone receptor PGR 0.0213
3823 Cytokine receptor common gamma chain IL2RG 0.0211
6171 Solute carrier family 28 member 3 SLC28A3 0.0209
844 Epidermal growth factor receptor EGFR 0.0208
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0207
2443 Azurin azu 0.0205
477 DNA topoisomerase 4 subunit A parC 0.0205
886 DNA topoisomerase 4 subunit A parC 0.0205
6226 DNA topoisomerase 4 subunit A parC 0.0205
856 Vitamin D3 receptor VDR 0.0205
4773 Deoxycytidine kinase DCK 0.0205
404 DNA gyrase subunit A gyrA 0.0202
6224 DNA gyrase subunit A gyrA 0.0202
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0201
3872 Somatostatin receptor type 5 SSTR5 0.02
6008 Somatostatin receptor type 2 SSTR2 0.02
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.02
5294 Nucleoside diphosphate kinase A NME1 0.0196
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0195
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0195
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0195
4035 Glutathione S-transferase Mu 5 GSTM5 0.0191
2049 Gastrin/cholecystokinin type B receptor CCKBR 0.0191
6210 Tubulin delta chain TUBD1 0.019
6211 Tubulin epsilon chain TUBE1 0.019
6212 Tubulin gamma-1 chain TUBG1 0.019
3076 Antigen 85-C fbpC 0.0187
1629 Transcription factor AP-1 JUN 0.0186
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0186
1159 Interleukin-6 IL6 0.0185
1928 Leukotriene C4 synthase LTC4S 0.0184
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0184
900 Glutathione S-transferase A4 GSTA4 0.0184
4037 Hypothetical protein GPX1 0.0184
4297 Hypothetical protein SP_1951 0.0184
4521 Hypothetical protein BC_2969 0.0184
4540 Hypothetical protein TM_1070 0.0184
4555 Hypothetical protein MT1739 0.0184
4569 Hypothetical protein mshD 0.0184
4578 Hypothetical protein PA3270 0.0184
4747 Hypothetical protein PA3967 0.0184
5177 Hypothetical protein TM_0096 0.0184
5194 Hypothetical protein PA1204 0.0184
5240 Hypothetical protein Rv2991 0.0184
5370 Hypothetical protein TM_1158 0.0184
5710 Hypothetical protein Tb927.5.1360 0.0184
4034 Glutaredoxin-1 GLRX 0.0184
906 Glutathione peroxidase 1 GPX1 0.0184
903 Glutathione S-transferase A5 GSTA5 0.0184
4029 Microsomal glutathione S-transferase 3 MGST3 0.0184
4032 Microsomal glutathione S-transferase 1 MGST1 0.0184
4042 Glutathione transferase omega-2 GSTO2 0.0184
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0184
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0184
4040 Glutathione peroxidase 7 GPX7 0.0184
4036 Glutathione peroxidase 6 GPX6 0.0184
724 Interleukin-2 receptor alpha chain IL2RA 0.0184
907 Glutathione peroxidase 2 GPX2 0.0184
4038 Glutathione peroxidase 4 GPX4 0.0184
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0184
911 Glutathione peroxidase 3 GPX3 0.0184
910 Epididymal secretory glutathione peroxidase GPX5 0.0184
4033 S-formylglutathione hydrolase ESD 0.0184
717 Interleukin-2 receptor subunit beta IL2RB 0.0184
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0184
1650 Heme carrier protein 1 SLC46A1 0.0183
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0182
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0182
4311 tRNA TRDMT1 0.0181
4325 tRNA trmD 0.0181
4328 tRNA trmD 0.0181
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.018
117 Sterol O-acyltransferase 1 SOAT1 0.018
6218 Pannexin-1 PANX1 0.018
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0178
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0176
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0176
632 Alpha-1B adrenergic receptor ADRA1B 0.0174
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0173
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0172
777 Tumor necrosis factor TNF 0.0172
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0172
84 Nuclear receptor 0B1 NR0B1 0.0172
327 Glutathione reductase gor 0.0171
5110 Glutathione reductase GR2 0.0171
672 Prostaglandin F2-alpha receptor PTGFR 0.017
737 Mineralocorticoid receptor NR3C2 0.0169
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0168
13 Aminomethyltransferase, mitochondrial AMT 0.0167
489 Monocarboxylate transporter 2 SLC16A7 0.0166
897 Glutathione S-transferase kappa 1 GSTK1 0.0166
63 Malate dehydrogenase mdh 0.0165
2329 Malate dehydrogenase mdh 0.0165
3445 Malate dehydrogenase mdh 0.0165
4420 Malate dehydrogenase mdh 0.0165
4438 Malate dehydrogenase mdh 0.0165
33 Cystine/glutamate transporter SLC7A11 0.0165
898 Glutathione S-transferase A3 GSTA3 0.0165
3319 Hydroxyacylglutathione hydrolase HAGH 0.0165
244 Angiotensin-converting enzyme ACE 0.0164
228 Beta platelet-derived growth factor receptor PDGFRB 0.0161
260 Cytochrome P450 51 ERG11 0.0161
761 Cytochrome P450 51 ERG11 0.0161
3163 Cytochrome P450 51 cyp51 0.0161
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0161
909 Maleylacetoacetate isomerase GSTZ1 0.0161
3426 Glutamine synthetase glnA 0.0161
3987 Glutamine synthetase GLUL 0.0161
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0161
115 Penicillin-binding protein 2 mrdA 0.016
6069 Penicillin-binding protein 2 mrdA 0.016
6118 Penicillin-binding protein 2 penA 0.016
6187 Penicillin-binding protein 2 pbpA 0.016
6686 Penicillin-binding protein 2 pbp2 0.016
6939 Penicillin-binding protein 2 mrdA 0.016
7163 Penicillin-binding protein 2 pbpA 0.016
867 Penicillin-binding protein 3 pbpC 0.016
6119 Penicillin-binding protein 3 pbp3 0.016
7154 Penicillin-binding protein 3 pbp3 0.016
7157 Penicillin-binding protein 3 LMHCC_2184 0.016
7162 Penicillin-binding protein 3 pbpB 0.016
7172 Penicillin-binding protein 3 pbp3 0.016
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.016
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0159
2449 Tubulin alpha-3 chain TUBA1A 0.0159
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0158
342 P protein [Includes: DNA-directed DNA polymerase P 0.0158
612 P protein [Includes: DNA-directed DNA polymerase P 0.0158
185 Vasopressin V1a receptor AVPR1A 0.0157
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0155
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0155
590 5-hydroxytryptamine 2C receptor HTR2C 0.0155
291 Nitric-oxide synthase, endothelial NOS3 0.0155
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0154
5898 Complement C3 C3 0.0154
322 Vasopressin V2 receptor AVPR2 0.0153
131 Synaptic vesicular amine transporter SLC18A2 0.0153
850 Vasopressin V1b receptor AVPR1B 0.0151
373 Transthyretin TTR 0.0151
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0151
789 Alpha-1D adrenergic receptor ADRA1D 0.015
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.015
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.015
6167 Organic solute transporter subunit beta OSTB 0.015
6166 Organic solute transporter subunit alpha OSTA 0.0149
893 [Citrate [pro-3S]-lyase] ligase citC 0.0149
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0149
638 D(3) dopamine receptor DRD3 0.0147
2796 Parathion hydrolase opd 0.0147
6539 Parathion hydrolase opd 0.0147
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0147
23 D(1A) dopamine receptor DRD1 0.0145
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0144
76 Nitric-oxide synthase, brain NOS1 0.0143
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0143
714 Glutathione reductase, mitochondrial GSR 0.0143
436 5-hydroxytryptamine 2B receptor HTR2B 0.0142
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0141
3454 Esterase estA 0.0141
482 Glycine receptor subunit alpha-1 GLRA1 0.014
869 Estrogen receptor beta ESR2 0.0139
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0139
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0139
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0139
207 Glutathione synthetase GSS 0.0138
5269 Glutathione synthetase gshB 0.0138
4226 Uridine phosphorylase 2 UPP2 0.0137
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0136
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0136
26 Vascular endothelial growth factor receptor 3 FLT4 0.0136
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0136
6043 Putative G-protein coupled receptor 44 GPR44 0.0135
847 Mu-type opioid receptor OPRM1 0.0135
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0134
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0134
407 Vascular endothelial growth factor receptor 2 KDR 0.0134
633 Penicillin-binding proteins 1A/1B pbpA 0.0132
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0131
444 Alcohol dehydrogenase 1B ADH1B 0.0131
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0131
32 Vascular endothelial growth factor receptor 1 FLT1 0.013
380 Cytochrome P450 17A1 CYP17A1 0.013
3685 Catabolite gene activator crp 0.013
320 5-hydroxytryptamine 1A receptor HTR1A 0.013
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.013
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.013
4655 Adenylate cyclase cyaC 0.013
4759 Adenylate cyclase cyaB2 0.013
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0129
891 Dihydropteroate synthase folP 0.0128
5359 Dihydropteroate synthase folP 0.0128
7175 Dihydropteroate synthase sulI 0.0128
284 DNA-directed RNA polymerase beta chain rpoB 0.0128
5773 DNA-directed RNA polymerase beta chain rpoB 0.0128
6677 Myelin P2 protein PMP2 0.0128
29 Tubulin beta-1 chain TUBB1 0.0127
293 Gamma-glutamyl hydrolase GGH 0.0126
4217 Telomerase reverse transcriptase TERT 0.0126
2539 Tubulin alpha-1 chain TUBA4A 0.0125
2929 (S)-2-haloacid dehalogenase dhlB 0.0124
2995 (S)-2-haloacid dehalogenase Not Available 0.0124
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0123
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0123
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0123
4225 Uridine phosphorylase 1 UPP1 0.0123
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0119
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0119
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0118
400 Coagulation factor IX F9 0.0118
5461 Coagulation factor IX F9 0.0118
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0118
413 Amidophosphoribosyltransferase PPAT 0.0117
2515 Amidophosphoribosyltransferase purF 0.0117
3714 Amidophosphoribosyltransferase purF 0.0117
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0116
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0116
696 Kappa-type opioid receptor OPRK1 0.0116
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0116
467 Delta-type opioid receptor OPRD1 0.0116
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0116
2517 Subtilisin BPN' apr 0.0116
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0115
1760 Aminopeptidase N ANPEP 0.0115
6843 Aminopeptidase N pepN 0.0115
3810 Catechol O-methyltransferase COMT 0.0115
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0114
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
3312 Fatty acid-binding protein, brain FABP7 0.0113
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0113
6599 HTH-type transcriptional regulator ttgR ttgR 0.0113
6042 Prostaglandin reductase 2 PTGR2 0.0112
3957 Adenosine deaminase ADA 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
551 Carnitine O-acetyltransferase CRAT 0.011
4760 Mll3241 protein mll3241 0.011
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.011
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.011
604 Vitamin K-dependent protein Z PROZ 0.011
469 Annexin A1 ANXA1 0.011
3639 Thymidine phosphorylase deoA 0.011
3936 Thymidine phosphorylase TYMP 0.011
6182 Cytochrome P450 2J2 CYP2J2 0.011
2981 Phospholipase A2, membrane associated PLA2G2A 0.0109
303 Diamine acetyltransferase 2 SAT2 0.0109
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0109
623 Spermine oxidase SMOX 0.0109
1317 Spermine synthase SMS 0.0109
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0109
6102 Arylamine N-acetyltransferase 2 NAT2 0.0109
6432 Transporter snf 0.0108
1192 Sulfotransferase 1A1 SULT1A1 0.0107
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0107
251 Alcohol dehydrogenase 1A ADH1A 0.0107
629 Alpha-2B adrenergic receptor ADRA2B 0.0107
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0107
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0107
756 Sex hormone-binding globulin SHBG 0.0106
2596 Acetyl-CoA acetyltransferase phbA 0.0105
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0104
378 Alpha-2C adrenergic receptor ADRA2C 0.0104
6859 Protein S100-A4 S100A4 0.0103
702 UMP-CMP kinase CMPK1 0.0102
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0102
517 Alcohol dehydrogenase 1C ADH1C 0.0101
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0101
1439 Lactotransferrin LTF 0.01
123 Diamine acetyltransferase 1 SAT1 0.01
1245 Vitamin K-dependent protein S PROS1 0.0099
422 Vitamin K-dependent protein C PROC 0.0099
4221 Vascular endothelial growth factor VEGF 0.0099
5816 Cadherin-5 CDH5 0.0099
3601 Dihydropteroate synthase 1 folP1 0.0099
3807 Dihydropteroate synthase 1 folP1 0.0099
3808 Dihydropteroate synthase 2 folP2 0.0099
885 5-hydroxytryptamine 1B receptor HTR1B 0.0099
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0098
603 DNA polymerase alpha catalytic subunit POLA1 0.0098
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0097
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0097
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0097
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0096
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0096
165 FL cytokine receptor FLT3 0.0095
2320 Thymidine kinase, cytosolic TK1 0.0095
569 Retinal dehydrogenase 2 ALDH1A2 0.0095
719 Retinoic acid receptor responder protein 1 RARRES1 0.0095
770 Retinoic acid-induced protein 3 GPRC5A 0.0095
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0095
4203 Histamine N-methyltransferase HNMT 0.0093
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0093
183 Vascular endothelial growth factor A VEGFA 0.0093
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
299 Folate receptor beta FOLR2 0.0093
718 Folate receptor gamma FOLR3 0.0092
804 Mitochondrial folate transporter/carrier SLC25A32 0.0092
992 Protein tyrosine kinase 2 beta PTK2B 0.0092
820 Glycine receptor subunit alpha-2 GLRA2 0.0092
780 Retinoic acid receptor RXR-gamma RXRG 0.0091
828 Phenylalanine-4-hydroxylase PAH 0.0091
3109 Phenylalanine-4-hydroxylase phhA 0.0091
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0091
1852 Microtubule-associated protein 2 MAP2 0.0089
611 Retinal dehydrogenase 1 ALDH1A1 0.0088
273 Apoptosis regulator Bcl-2 BCL2 0.0088
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0088
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0088
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0088
798 Osteocalcin BGLAP 0.0088
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0087
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0087
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0087
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
6010 Thiamine transporter 1 SLC19A2 0.0086
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0086
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0086
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0085
1517 Beta-3 adrenergic receptor ADRB3 0.0085
174 Sigma 1-type opioid receptor SIGMAR1 0.0082
527 Prostacyclin receptor PTGIR 0.0082
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0081
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0081
88 Retinoic acid receptor RXR-beta RXRB 0.0081
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0081
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0081
3587 Gastrotropin FABP6 0.008
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.008
952 Dipeptidyl peptidase 4 DPP4 0.008
369 Coagulation factor VII F7 0.0079
5923 Microtubule-associated protein tau MAPT 0.0079
5924 Microtubule-associated protein 4 MAP4 0.0079
921 Glutamate receptor 2 GRIA2 0.0079
365 Dihydrofolate reductase DHFR 0.0079
2381 Dihydrofolate reductase DFR1 0.0079
2833 Dihydrofolate reductase Not Available 0.0079
2931 Dihydrofolate reductase folA 0.0079
3544 Dihydrofolate reductase folA 0.0079
3682 Dihydrofolate reductase folA 0.0079
6642 Dihydrofolate reductase folA 0.0079
6756 Dihydrofolate reductase dfrA 0.0079
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0079
461 Glycine receptor subunit alpha-3 GLRA3 0.0079
725 5-hydroxytryptamine 1D receptor HTR1D 0.0078
449 Ornithine decarboxylase ODC1 0.0078
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0078
823 Fibroblast growth factor receptor 2 FGFR2 0.0077
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0077
175 Thiamin pyrophosphokinase 1 TPK1 0.0077
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0076
703 NADPH azoreductase azr 0.0076
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0075
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
661 ADP/ATP translocase 1 SLC25A4 0.0074
130 Prostacyclin synthase PTGIS 0.0074
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0074
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0073
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0073
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0072
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0072
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0072
2298 Cytochrome P450-cam camC 0.0072
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0072
1618 High affinity nerve growth factor receptor NTRK1 0.0071
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0071
362 Melatonin receptor type 1B MTNR1B 0.0071
571 Melatonin receptor type 1A MTNR1A 0.0071
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.007
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.007
2808 Chloramphenicol acetyltransferase 3 cat3 0.007
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.007
1770 Phospholipase C PLCL1 0.007
2841 Phospholipase C plc 0.007
5787 Angiopoietin-1 receptor TEK 0.0069
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0068
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0068
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0068
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0068
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0068
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0068
3809 Estrogen-related receptor gamma ESRRG 0.0067
3480 Mannan endo-1,4-beta-mannosidase manA 0.0067
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0067
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0067
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0066
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0066
6036 Eosinophil peroxidase EPX 0.0066
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0065
3830 Calreticulin CALR 0.0065
162 Retinoic acid receptor gamma-1 RARG 0.0064
1374 Natriuretic peptides B NPPB 0.0064
1827 Gap junction alpha-1 protein GJA1 0.0064
1908 Vascular cell adhesion protein 1 VCAM1 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
3270 Elongation factor G fusA 0.0062
1648 Elastin ELN 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
6034 Hydroxyindole O-methyltransferase ASMT 0.0062
6035 Nuclear receptor ROR-beta RORB 0.0062
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0062
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0061
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0061
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0061
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0061
3709 Glycerol uptake facilitator protein glpF 0.0061
3116 Bacterioferritin bfr 0.0061
4906 Bacterioferritin bfr 0.0061
4965 Bacterioferritin bfr 0.0061
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0061
3173 Enolase eno 0.006
811 Translocator protein TSPO 0.006
3393 TGF-beta receptor type-2 TGFBR2 0.006
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.006
3238 Multidrug resistance protein mexA mexA 0.006
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.006
3611 Cytidine deaminase cdd 0.0059
3707 Cytidine deaminase cdd 0.0059
4211 Cytidine deaminase CDA 0.0059
3221 Cytochrome c4 cc4 0.0059
694 Matrix protein 2 M 0.0059
818 50S ribosomal protein L10 rplJ 0.0059
6500 Phospholipase A2 PLA2G1B 0.0058
1714 Mitogen-activated protein kinase 3 MAPK3 0.0058
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0057
427 Substance-P receptor TACR1 0.0057
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0057
6138 Multidrug resistance protein 3 ABCB4 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0056
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0056
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0056
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0056
6459 Glycodelin PAEP 0.0056
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0056
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0056
1178 Adenosine A2a receptor ADORA2A 0.0055
1275 Estrogen sulfotransferase SULT1E1 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
459 Retinoic acid receptor RXR-alpha RXRA 0.0054
597 Dihydropteridine reductase QDPR 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
765 Indoleamine 2,3-dioxygenase IDO1 0.0053
6111 DNA polymerase epsilon subunit 4 POLE4 0.0053
6112 DNA polymerase epsilon subunit 3 POLE3 0.0053
6014 Cytochrome P450 2A13 CYP2A13 0.0053
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0053
6110 DNA polymerase epsilon subunit 2 POLE2 0.0053
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0053
1010 Cytochrome P450 51A1 CYP51A1 0.0053
537 ATP synthase delta chain, mitochondrial ATP5D 0.0053
2852 DNA mismatch repair protein mutL mutL 0.0053
5818 Folate receptor alpha FOLR1 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
2232 Interleukin-5 IL5 0.0051
1593 Mucin-2 MUC2 0.0051
4132 Chloride channel protein ClC-Ka CLCNKA 0.0051
6164 POU domain, class 5, transcription factor 1 POU5F1 0.005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.005
432 D(4) dopamine receptor DRD4 0.0049
3191 Histidinol dehydrogenase hisD 0.0049
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0049
106 Cannabinoid receptor 2 CNR2 0.0048
6070 Nischarin NISCH 0.0048
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0048
5449 Hypothetical gliding protein mglB 0.0047
5448 Ribonuclease Z rnz 0.0047
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0047
4705 Manganese catalase Not Available 0.0047
5443 UPF0189 protein ymdB ymdB 0.0047
5440 UPF0067 protein yebR yebR 0.0047
5439 33 kDa chaperonin hslO 0.0047
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0047
332 Beta-lactamase blaZ 0.0047
2478 Beta-lactamase ampC 0.0047
2613 Beta-lactamase ampC 0.0047
2635 Beta-lactamase ampC 0.0047
2700 Beta-lactamase penP 0.0047
5445 Beta-lactamase blaB 0.0047
6019 Beta-lactamase SHV-7 0.0047
6701 Beta-lactamase cphA 0.0047
2720 Copper-containing nitrite reductase nirK 0.0047
5454 Internalin-A inlA 0.0047
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0047
511 5-hydroxytryptamine 1F receptor HTR1F 0.0047
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0047
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0047
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0047
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
936 Ephrin type-A receptor 2 EPHA2 0.0047
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0047
4498 Ornithine cyclodeaminase PP3533 0.0047
1630 Integrin beta-2 ITGB2 0.0046
144 Hemoglobin subunit alpha HBA1 0.0046
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0046
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0046
4784 Beta-mannosidase manB 0.0046
6695 Beta-mannosidase BT_0458 0.0046
3856 Fibroblast growth factor receptor 3 FGFR3 0.0046
705 Glutamate receptor 1 GRIA1 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
295 Carbonic anhydrase 1 CA1 0.0046
751 Potassium channel subfamily K member 6 KCNK6 0.0046
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0046
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0046
164 Histamine H4 receptor HRH4 0.0045
319 Opioid receptor, sigma 1 OPRS1 0.0045
716 5-hydroxytryptamine 7 receptor HTR7 0.0045
605 Fumarate reductase flavoprotein subunit frdA 0.0045
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0045
3673 Fumarate reductase flavoprotein subunit fccA 0.0045
4912 Fumarate reductase flavoprotein subunit ifcA 0.0045
6549 Fumarate reductase flavoprotein subunit frdA 0.0045
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0045
4692 A/G-specific adenine glycosylase mutY 0.0045
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
6837 Serine/threonine-protein kinase 17B STK17B 0.0044
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0044
49 Endothelin B receptor EDNRB 0.0044
2472 Voltage-gated potassium channel kcsA 0.0043
6366 Voltage-gated potassium channel kcsA 0.0043
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0043
6033 High affinity interleukin-8 receptor A CXCR1 0.0043
2802 Endoglucanase G celCCG 0.0042
1123 Eosinophil cationic protein RNASE3 0.0042
172 Potassium channel subfamily K member 1 KCNK1 0.0042
1830 5'-nucleotidase NT5E 0.0042
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0042
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0042
5450 Prolyl endopeptidase Pep pep 0.0042
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0042
1341 Histamine H3 receptor HRH3 0.0041
3356 Diaminopimelate decarboxylase lysA 0.0041
4771 Dissimilatory copper-containing nitrite reductase nir 0.0041
4608 Putative cytochrome P450 SCO1207 0.0041
4963 Putative cytochrome P450 SCO2884 0.0041
6254 Putative cytochrome P450 SCO6998 0.0041
6316 ADP-ribosylation factor 1 ARF1 0.0041
163 D(1B) dopamine receptor DRD5 0.0041
2714 Chorismate mutase aroH 0.0041
4611 Chorismate mutase aroG 0.0041
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0041
3274 Hydroxylamine reductase hcp 0.0041
4804 Hydroxylamine reductase hcp 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
1864 RET proto-oncogene RET 0.0041
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0041
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0041
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0041
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.004
357 Carbonic anhydrase 2 CA2 0.004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.004
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.004
125 DNA polymerase beta POLB 0.004
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0039
2207 Rhodopsin RHO 0.0039
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0039
976 Platelet glycoprotein IX GP9 0.0038
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0038
3399 Limonene-1,2-epoxide hydrolase limA 0.0038
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0038
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0038
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0038
2391 Ferrochelatase hemH 0.0038
6502 Ferrochelatase DKFZp686P18130 0.0038
1591 Ferrochelatase, mitochondrial FECH 0.0038
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0037
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0037
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0037
3927 Choline transporter-like protein 3 SLC44A3 0.0037
3926 Choline transporter-like protein 2 SLC44A2 0.0037
861 Choline kinase alpha CHKA 0.0037
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0037
3925 Choline transporter-like protein 4 SLC44A4 0.0037
1686 Choline transporter-like protein 1 SLC44A1 0.0037
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0037
769 High-affinity choline transporter 1 SLC5A7 0.0037
700 Choline dehydrogenase, mitochondrial CHDH 0.0037
576 Choline O-acetyltransferase CHAT 0.0037
3922 Phospholipase D2 PLD2 0.0037
3924 Phospholipase D1 PLD1 0.0037
5180 L(+)-mandelate dehydrogenase mdlB 0.0036
3500 Putative family 31 glucosidase yicI yicI 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
4787 Envelope glycoprotein gp160 env 0.0036
4820 Envelope glycoprotein gp160 env 0.0036
5727 Envelope glycoprotein gp160 env 0.0036
1569 G1/S-specific cyclin-D1 CCND1 0.0036
577 Argininosuccinate lyase ASL 0.0036
94 5-hydroxytryptamine 4 receptor HTR4 0.0035
5126 Arginase rocF 0.0035
592 Carbonic anhydrase 4 CA4 0.0035
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0035
1615 Chymase CMA1 0.0035
5798 Mitogen-activated protein kinase 11 MAPK11 0.0034
2297 Genome polyprotein Not Available 0.0034
2322 Genome polyprotein Not Available 0.0034
2694 Genome polyprotein Not Available 0.0034
2719 Genome polyprotein Not Available 0.0034
2860 Genome polyprotein Not Available 0.0034
2928 Genome polyprotein Not Available 0.0034
3160 Genome polyprotein Not Available 0.0034
3260 Genome polyprotein Not Available 0.0034
4783 Genome polyprotein Not Available 0.0034
5726 Genome polyprotein Not Available 0.0034
5779 Genome polyprotein Not Available 0.0034
5867 Genome polyprotein Not Available 0.0034
6253 Genome polyprotein Not Available 0.0034
6301 Genome polyprotein Not Available 0.0034
6380 Genome polyprotein Not Available 0.0034
6381 Genome polyprotein Not Available 0.0034
6437 Genome polyprotein Not Available 0.0034
6520 Genome polyprotein Not Available 0.0034
6521 Genome polyprotein Not Available 0.0034
6652 Genome polyprotein Not Available 0.0034
6734 Genome polyprotein Not Available 0.0034
6735 Genome polyprotein Not Available 0.0034
6736 Genome polyprotein Not Available 0.0034
6737 Genome polyprotein Not Available 0.0034
6738 Genome polyprotein Not Available 0.0034
6739 Genome polyprotein Not Available 0.0034
6744 Genome polyprotein Not Available 0.0034
6748 Genome polyprotein Not Available 0.0034
6894 Genome polyprotein Not Available 0.0034
6898 Genome polyprotein Not Available 0.0034
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0034
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0034
3102 Flavohemoprotein hmp 0.0034
4969 Flavohemoprotein hmp 0.0034
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0033
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0033
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0033
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0033
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0033
6493 Cytochrome c oxidase subunit 6C COX6C 0.0033
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0033
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0033
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0033
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0033
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0033
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0033
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0033
6559 Cytochrome c oxidase subunit 2 ctaC 0.0033
6669 Cytochrome c oxidase subunit 2 ctaC 0.0033
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0033
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0033
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0033
6558 Cytochrome c oxidase subunit 1 ctaD 0.0033
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0033
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0032
759 Free fatty acid receptor 1 FFAR1 0.0032
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0032
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0032
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0032
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0032
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0032
5122 Mersacidin decarboxylase mrsD 0.0031
5078 Amine oxidase, flavin-containing PSPTO1126 0.0031
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0031
526 Thioredoxin reductase trxB 0.0031
3767 Thioredoxin reductase trxB 0.0031
3763 5,10-methylenetetrahydrofolate reductase metF 0.0031
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0031
5094 5,10-methylenetetrahydrofolate reductase metF 0.0031
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0031
5095 Putidaredoxin reductase camA 0.0031
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0031
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0031
5109 Outer membrane protein p64k or PM-6 m-6 0.0031
5115 FkbI fkbI 0.0031
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0031
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0031
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0031
5083 Cryptochrome DASH cry 0.0031
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0031
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0031
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0031
5081 L-aspartate oxidase nadB 0.0031
3133 UDP-galactopyranose mutase glf 0.0031
5099 UDP-galactopyranose mutase glf 0.0031
1410 Oxidoreductase HSD17B6 0.0031
4725 Oxidoreductase Not Available 0.0031
5124 Oxidoreductase Not Available 0.0031
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0031
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0031
5111 Phenylacetone monooxygenase pamO 0.0031
4486 Phenol 2-hydroxylase component B pheA2 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
4477 Dihydrolipoyl dehydrogenase lpdV 0.0031
5077 Dihydrolipoyl dehydrogenase Not Available 0.0031
5117 Dihydrolipoyl dehydrogenase lpd 0.0031
4439 Ferredoxin reductase bphA4 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0031
277 Purine nucleoside phosphorylase PNP 0.0031
2870 Purine nucleoside phosphorylase punA 0.0031
2945 Purine nucleoside phosphorylase punA 0.0031
4659 Purine nucleoside phosphorylase TM_1596 0.0031
4825 Purine nucleoside phosphorylase TTHA1435 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
484 Tyrosine-protein kinase ABL2 ABL2 0.003
3437 Eosinophil lysophospholipase CLC 0.003
2300 Lysozyme E 0.003
3633 Lysozyme R 0.003
5597 Lysozyme 17 0.003
2540 Choloylglycine hydrolase cbh 0.003
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.003
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.003
6824 Tyrosine-protein kinase Lyn LYN 0.003
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0029
822 Aldose reductase AKR1B1 0.0029
683 Potassium transporter GK0582 0.0029
6501 Fatty acid-binding protein, liver FABP1 0.0028
1053 BC269730_2 FADS1 0.0028
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0028
1395 Sodium/calcium exchanger 1 SLC8A1 0.0028
4122 Histone deacetylase 2 HDAC2 0.0028
1360 Sphingomyelin phosphodiesterase SMPD1 0.0028
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0027
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0027
5072 N,N-dimethylglycine oxidase dmg 0.0027
5073 Ferredoxin--NADP reductase petH 0.0027
5076 Ferredoxin--NADP reductase fpr 0.0027
5119 Ferredoxin--NADP reductase petH 0.0027
5121 Ferredoxin--NADP reductase fpr 0.0027
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0027
3594 Deoxyribodipyrimidine photo-lyase phr 0.0027
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0027
5080 Deoxyribodipyrimidine photo-lyase phr 0.0027
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0027
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0027
2526 NADPH-ferredoxin reductase fprA fprA 0.0027
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0027
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0027
2470 Pyruvate oxidase pox5 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
2268 Cholesterol oxidase choB 0.0027
2822 Cholesterol oxidase choA 0.0027
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0027
624 Guanidinoacetate N-methyltransferase GAMT 0.0027
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0027
2021 Thrombomodulin THBD 0.0027
6044 Serum paraoxonase/lactonase 3 PON3 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0027
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
1262 Corticotropin-lipotropin POMC 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
3814 Complement C1r subcomponent C1R 0.0026
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0026
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0025
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0025
572 Integrin alpha-L ITGAL 0.0025
2893 Glycine oxidase thiO 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
126 D-lactate dehydrogenase dld 0.0025
3545 D-lactate dehydrogenase Not Available 0.0025
4510 D-lactate dehydrogenase ldhA 0.0025
1541 Metalloproteinase mmp20 0.0025
310 Solute carrier family 12 member 2 SLC12A2 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
2567 Thymidylate synthase thyX thyX 0.0024
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0024
1176 Mitogen-activated protein kinase 1 MAPK1 0.0024
2823 Trypanothione reductase TPR 0.0024
528 5-hydroxytryptamine 1E receptor HTR1E 0.0024
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0024
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
2216 Fibroblast growth factor receptor 4 FGFR4 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
1063 Signal transducer and activator of transcription 5B STAT5B 0.0023
6228 Nuclear receptor coactivator 1 NCOA1 0.0023
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0023
1050 Bile salt sulfotransferase SULT2A1 0.0023
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
2769 P-hydroxybenzoate hydroxylase pobA 0.0023
2809 P-hydroxybenzoate hydroxylase pobA 0.0023
581 Cytochrome P450 2R1 CYP2R1 0.0023
2782 Complement C1s subcomponent C1S 0.0022
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0022
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0022
4785 Ig gamma-1 chain C region IGHG1 0.0022
2380 Monomeric sarcosine oxidase soxA 0.0022
1992 Vitamin D-binding protein GC 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0021
6645 D-amino-acid oxidase DAO 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
6174 50S ribosomal protein L32 rpmF 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
2240 Cell division protein kinase 2 CDK2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
5682 Ribonuclease pancreatic RNASE1 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
1792 Tissue-type plasminogen activator PLAT 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0018
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0018
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0018
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0018
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0018
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0018
816 Biliverdin reductase A BLVRA 0.0018
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0018
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0018
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
5934 Cytochrome P450 26A1 CYP26A1 0.0018
760 Fibroblast growth factor 1 FGF1 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0017
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0017
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0017
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0017
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0017
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0017
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0017
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0017
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0017
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0017
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0017
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0017
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0017
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0017
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0017
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0017
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0017
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0017
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0017
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0017
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0017
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0017
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0017
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0017
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0017
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0017
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0017
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0017
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0017
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0017
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0017
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0017
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0017
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0017
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0017
644 Heme oxygenase 2 HMOX2 0.0017
4982 Heme oxygenase 2 pbsA2 0.0017
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0017
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0017
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0017
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0017
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0017
729 GDP-L-fucose synthetase TSTA3 0.0017
3463 GDP-L-fucose synthetase fcl 0.0017
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0017
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0017
167 L-lactate dehydrogenase C chain LDHC 0.0017
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0017
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0017
206 3-keto-steroid reductase HSD17B7 0.0017
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0017
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0017
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0017
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0017
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0017
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0017
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0017
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0017
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0017
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0017
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0017
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0017
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0017
518 Peroxidase/catalase T katG 0.0017
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0017
3726 D-3-phosphoglycerate dehydrogenase serA 0.0017
4291 D-3-phosphoglycerate dehydrogenase serA 0.0017
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0017
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0017
34 7-dehydrocholesterol reductase DHCR7 0.0017
711 UDP-glucose 6-dehydrogenase UGDH 0.0017
3672 UDP-glucose 6-dehydrogenase hasB 0.0017
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0017
107 C-4 methylsterol oxidase SC4MOL 0.0017
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0017
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0017
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0017
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0017
643 Peroxisomal bifunctional enzyme EHHADH 0.0017
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0017
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
2183 Fatty acid-binding protein, adipocyte FABP4 0.0016
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
646 Malate dehydrogenase, cytoplasmic MDH1 0.0016
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0016
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0016
328 Sorbitol dehydrogenase SORD 0.0016
396 Alcohol dehydrogenase 4 ADH4 0.0016
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0016
2853 14 kDa fatty acid-binding protein Not Available 0.0015
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0015
6755 Poliovirus receptor PVR 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
208 DNA-directed RNA polymerase beta' chain rpoC 0.0015
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0015
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
16 Adenosine A1 receptor ADORA1 0.0015
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0015
666 NADP-dependent malic enzyme ME1 0.0015
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0015
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
857 Malate dehydrogenase, mitochondrial MDH2 0.0014
627 11-cis retinol dehydrogenase RDH5 0.0014
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0014
6026 Alcohol dehydrogenase 6 ADH6 0.0014
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0014
12 Alcohol dehydrogenase class 3 ADH5 0.0014
77 L-lactate dehydrogenase B chain LDHB 0.0014
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0014
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0014
626 Cysteine dioxygenase type 1 CDO1 0.0014
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0014
1268 Neuropeptide S receptor NPSR1 0.0014
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0014
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0013
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0013
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0013
6221 Steroid hormone receptor ERR1 ESRRA 0.0013
473 L-lactate dehydrogenase A chain LDHA 0.0013
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
4948 Cytochrome c-553 Not Available 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
4923 Cytochrome c3 DvMF_2499 0.0013
4945 Cytochrome c3 Not Available 0.0013
4949 Cytochrome c3 DVU_3171 0.0013
4968 Cytochrome c3 cytc3 0.0013
4997 Cytochrome c3 SO_2727 0.0013
5219 Cytochrome c3 cyd 0.0013
4902 Nine-heme cytochrome c Ddes_2038 0.0013
3189 High-molecular-weight cytochrome c hmcA 0.0013
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
814 Ryanodine receptor 1 RYR1 0.0013
6073 Potassium channel subfamily K member 9 KCNK9 0.0013
6072 Potassium channel subfamily K member 3 KCNK3 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0012
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
279 Tyrosinase TYR 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
3937 Fatty-acid amide hydrolase FAAH 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
292 Activin receptor type-1 ACVR1 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
6048 Troponin C, skeletal muscle TNNC2 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
654 Flavin reductase BLVRB 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0011
4386 Hemoglobin-like protein HbN glbN 0.0011
1256 5-hydroxytryptamine 6 receptor HTR6 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
1196 Complement decay-accelerating factor CD55 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
4954 Soluble cytochrome b558 Not Available 0.001
4943 Cytochrome c6 petJ 0.001
4925 Cytochrome c-type protein SHP shp 0.001
4984 Neuroglobin NGB 0.001
4934 Cytochrome c-551 nirM 0.001
5218 Cytochrome c-551 nirM 0.001
4905 Cytochrome c2 Not Available 0.001
4939 Cytochrome c2 cycA 0.001
4964 Cytochrome c2 cycA 0.001
4979 Cytochrome c2 cycA 0.001
6673 Cytochrome c2 cycA 0.001
4947 Bacterial hemoglobin vhb 0.001
4994 Hemoglobin-like protein HbO glbO 0.001
4916 Cyanoglobin glbN 0.001
4998 Hemoglobin-like protein yjbI yjbI 0.001
4915 Cytochrome c-550 psbV 0.001
4959 Cytochrome c-550 psbV 0.001
5216 Cytochrome c-550 psbV 0.001
4910 Cytoglobin CYGB 0.001
4975 Cytochrome c-556 RPA3973 0.001
4942 Diheme cytochrome c napB napB 0.001
4936 Cytochrome c2 iso-2 Not Available 0.001
5000 HemO hemO 0.001
4961 Hemophore HasA hasA 0.001
4907 Cytochrome c-L moxG 0.001
6865 Cytochrome c-L moxG 0.001
4981 Iron-starvation protein PigA pigA 0.001
4909 CooA protein cooA 0.001
4971 Nonaheme cytochrome c hmcA 0.001
4904 Cytochrome c family protein GSU1996 0.001
4764 Cytochrome P450 165C4 CYP165C4 0.001
4935 Cytochrome c-554 cycA1 0.001
4976 Apocytochrome f petA 0.001
6407 Apocytochrome f petA 0.001
4999 Cytochrome P450 165B3 CYP165B3 0.001
4989 Cytochrome c551 peroxidase ccp 0.001
5222 Cytochrome c551 peroxidase ccpA 0.001
4972 P450cin cinA 0.001
4960 Putative cytochrome P450-family protein SCO7417 0.001
4931 Cytochrome P450 167A1 CYP167A1 0.001
4937 Cytochrome oxidase subunit II rcoxA 0.001
4926 Heme-based aerotactic transducer hemAT hemAT 0.001
4922 Cytochrome c, putative SO_4144 0.001
4993 Hydroxylamine oxidoreductase hao1 0.001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.001
4903 Methyl-accepting chemotaxis protein Tar4 0.001
4952 Catalase/peroxidase katA 0.001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.001
3093 Catalase HPII katE 0.001
6021 Adenosine kinase ADK 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
4878 Glycoprotein hormones alpha chain CGA 0.0009
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0009
1072 Granzyme B GZMB 0.0009
4889 Ig epsilon chain C region IGHE 0.0009
4877 Beta-mannanase man 0.0009
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0009
4189 Alpha-galactosidase A GLA 0.0009
4850 Beta-2-glycoprotein 1 APOH 0.0009
4880 Membrane cofactor protein CD46 0.0009
4856 CD209 antigen CD209 0.0009
1354 Beta-glucuronidase GUSB 0.0009
757 Fusion glycoprotein F0 F 0.0009
4875 Fusion glycoprotein F0 F 0.0009
4869 Major capsid protein A430L 0.0009
4852 Reticulon-4 receptor RTN4R 0.0009
4845 ADAM 33 ADAM33 0.0009
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0009
442 Envelope glycoprotein gp41 0.0009
4859 Envelope glycoprotein env 0.0009
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0009
4721 Beta-1,4-mannanase manA 0.0009
3352 Structural polyprotein Not Available 0.0009
3628 Structural polyprotein Not Available 0.0009
4892 Structural polyprotein Not Available 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
1507 Cytochrome c CYCS 0.0009
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0009
2417 Chloramphenicol acetyltransferase cat 0.0008
3278 Chloramphenicol acetyltransferase cat 0.0008
2810 Dr hemagglutinin structural subunit draA 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
4861 Interleukin-6 receptor alpha chain IL6R 0.0008
793 T-cell surface antigen CD2 CD2 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0008
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0008
3837 Cytokine receptor common beta chain CSF2RB 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
4920 Peroxidase/catalase katG 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
2119 Cytochrome b5 CYB5A 0.0007
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0007
4990 PpcA ppcA 0.0007
4988 Sulfite oxidase, mitochondrial SUOX 0.0007
4289 Cytochrome P450 TT_P0059 0.0007
6262 Cytochrome P450 staP 0.0007
3570 Cytochrome P450 152A1 cypC 0.0007
4992 Cytochrome c peroxidase Not Available 0.0007
2915 Sensor protein fixL fixL 0.0007
4944 Sensor protein fixL fixL 0.0007
3375 Acidic cytochrome c3 Not Available 0.0007
4385 Cytochrome c' Not Available 0.0007
4967 Cytochrome c' cycA 0.0007
5038 Cytochrome c' Not Available 0.0007
5223 Cytochrome c' cycP 0.0007
4813 Heme oxygenase hmuO 0.0007
5769 Heme oxygenase Not Available 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
4890 Hemagglutinin HA 0.0007
6566 Hemagglutinin Not Available 0.0007
1379 Interleukin-12 subunit beta IL12B 0.0007
2230 Catalase CAT 0.0007
3249 Catalase katA 0.0007
3625 Catalase katA 0.0007
4539 Catalase katA 0.0007
4941 Catalase katB 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0007
6858 Inactive carboxylesterase 4 CES1P1 0.0007
1184 Interferon beta IFNB1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0007
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0006
554 Low-density lipoprotein receptor LDLR 0.0006
852 Heparin cofactor 2 SERPIND1 0.0006
3670 Soluble cytochrome b562 precursor cybC 0.0006
3411 Cytochrome P450 121 cyp121 0.0006
2617 Nitric oxide synthase oxygenase nos 0.0006
2701 Nitric oxide synthase oxygenase nos 0.0006
3291 Cytochrome c-552 cycA 0.0006
4927 Cytochrome c-552 nrfA 0.0006
4938 Cytochrome c-552 cycA 0.0006
4953 Cytochrome c-552 nrfA 0.0006
5217 Cytochrome c-552 cycM 0.0006
1859 Prostatic acid phosphatase ACPP 0.0006
3444 Cyanovirin-N Not Available 0.0006
3140 Hemagglutinin-neuraminidase HN 0.0006
3609 Hemagglutinin-neuraminidase HN 0.0006
595 Fibrinogen alpha chain FGA 0.0006
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
4666 Fucose-binding lectin PA-IIL lecB 0.0005
2372 Bifunctional tail protein 9 0.0005
958 Insulin-like growth factor 1 receptor IGF1R 0.0005
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0005
64 Neuraminidase NA 0.0005
641 Neuraminidase NA 0.0005
2676 Neuraminidase NA 0.0005
3026 Neuraminidase NA 0.0005
3519 Neuraminidase NA 0.0005
6007 Neuraminidase NA 0.0005
1243 Cathepsin D CTSD 0.0005
358 Cystathionine beta-synthase CBS 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0005
693 Hemoglobin subunit beta HBB 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0004
2430 Chondroitinase B cslB 0.0004
6307 Ig gamma-2 chain C region IGHG2 0.0004
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0004
2581 Chondroitinase AC cslA 0.0004
6847 Lactase-phlorizin hydrolase LCT 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
↑