DT-Web

DB00903 - Ethacrynic acid


Identification
Name Ethacrynic acid
Accession Number DB00903 (APRD00251)
Type small molecule
Description A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 303.138
Groups approved
Monoisotopic Weight 302.011264286
Pharmacology
Indication For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.
Mechanism of action Ethacrynic acid inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. Diuretics also lower blood pressure initially by reducing plasma and extracellular fluid volume; cardiac output also decreases, explaining its antihypertensive action. Eventually, cardiac output returns to normal with an accompanying decrease in peripheral resistance. Its mode of action does not involve carbonic anhydrase inhibition.
Absorption Onset of action is rapid, usually within 30 minutes after an oral dose of ethacrynic acid or within 5 minutes after an intravenous injection of ethacrynic acid.
Protein binding > 98%
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Overdosage may lead to excessive diuresis with electrolyte depletion.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin Increased ototoxicity
Cisplatin Increased ototoxicity
Colesevelam Bile acid sequestrants such as colesevelam may decrease the absorption of loop diuretics such as ethacrynic acid. Monitor for decreased serum concentrations/therapeutic effects of loop diuretics if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Deslanoside Possible electrolyte variations and arrhythmias
Digitoxin Possible electrolyte variations and arrhythmias
Digoxin Possible electrolyte variations and arrhythmias
Gentamicin Increased ototoxicity
Ginseng Ginseng may decrease the therapeutic effect of diuretic, ethacrynic acid.
Ibuprofen The NSAID, ibuprofen, may antagonize the diuretic and antihypertensive effects of the loop diuretic, ethacrynic acid.
Indacaterol Concomitant therapy may increase the risk of hypokalemia via intracellular shunting. Monitor for adverse effects and especially for cardiovascular effects associated with hypokalemia.
Indomethacin The NSAID, indomethacin, may decrease the diuretic and antihypertensive effects of the loop diuretic, ethacrynic acid.
Kanamycin Increased ototoxicity
Netilmicin Increased ototoxicity
Streptomycin Increased ototoxicity
Sulindac The NSAID, sulindac, may decrease the diuretic and antihypertensive effects of the loop diuretic, ethacryninc acid.
Tobramycin Increased ototoxicity
Trandolapril The loop diuretic, Ethacrynic acid, may increase the hypotensive effect of Trandolapril. Ethacrynic acid may also increase the nephrotoxicity of Trandolapril.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Food Interactions
  • Take with food to reduce irritation.

Targets


Sodium/potassium-transporting ATPase alpha-1 chain
Name Sodium/potassium-transporting ATPase alpha-1 chain
Gene Name ATP1A1
Pharmacological action yes
Actions inhibitor
References
  • Ronquist G, Agren GK: A Mg2+- and Ca2+-stimulated adenosine triphosphatase at the outer surface of Ehrlich ascites tumor cells. Cancer Res. 1975 Jun;35(6):1402-6. - Pubmed
  • Proverbio F, Condrescu-Guidi M, Whittembury G: Ouabain-insensitive Na+ stimulation of an Mg-2+ -dependent ATPase in kidney tissue. Biochim Biophys Acta. 1975 Jun 25;394(2):281-92. - Pubmed
  • Valdes RM, Huff MO, El-Masri MA, El-Mallakh RS: Effect of ethacrynic acid on sodium pump alpha isoforms in SH-SY5Y cells. Bipolar Disord. 2003 Apr;5(2):123-8. - Pubmed
  • Kiil F, Sejersted OM: Analysis of energy metabolism and mechanism of loop diuretics in the thick ascending limb of Henle's loop in dog kidneys. Acta Physiol Scand. 2003 May;178(1):73-82. - Pubmed
  • Schurek HJ, Aulbert E, Ebel H, Muller-Suur C: Influence of ouabain and ethacrynic acid on sodium transport and NaK-ATPase activity in the isolated perfused rat kidney. Curr Probl Clin Biochem. 1975;4:162-8. - Pubmed
DTHybrid score 0.8371
Solute carrier family 12 member 1
Name Solute carrier family 12 member 1
Gene Name SLC12A1
Pharmacological action yes
Actions inhibitor
References
  • Bowes TJ, Gupta RS: Induction of mitochondrial fusion by cysteine-alkylators ethacrynic acid and N-ethylmaleimide. J Cell Physiol. 2005 Mar;202(3):796-804. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5759

Enzymes


Glutathione S-transferase A2
Name Glutathione S-transferase A2
Gene Name GSTA2
Actions inhibitor
References
  • Depeille P, Cuq P, Passagne I, Evrard A, Vian L: Combined effects of GSTP1 and MRP1 in melanoma drug resistance. Br J Cancer. 2005 Jul 25;93(2):216-23. - Pubmed
  • Awasthi S, Srivastava SK, Ahmad F, Ahmad H, Ansari GA: Interactions of glutathione S-transferase-pi with ethacrynic acid and its glutathione conjugate. Biochim Biophys Acta. 1993 Jul 10;1164(2):173-8. - Pubmed
  • Iersel ML, Ploemen JP, Struik I, van Amersfoort C, Keyzer AE, Schefferlie JG, van Bladeren PJ: Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal. Chem Biol Interact. 1996 Oct 21;102(2):117-32. - Pubmed
  • van Iersel ML, Ploemen JP, Lo Bello M, Federici G, van Bladeren PJ: Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1. Chem Biol Interact. 1997 Dec 12;108(1-2):67-78. - Pubmed
  • Morrow CS, Smitherman PK, Townsend AJ: Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin. Biochem Pharmacol. 1998 Oct 15;56(8):1013-21. - Pubmed
DTHybrid score 0.2179

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H: Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem. 1997 Jul 25;272(30):18526-9. - Pubmed
DTHybrid score 0.3027

Carriers


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions
References Not Available
DTHybrid score 0.3027

Predictions


Id Partner name Gene Name Score
295 Carbonic anhydrase 1 CA1 0.1063
6142 Solute carrier family 22 member 8 SLC22A8 0.0915
4512 Cytochrome P450 3A4 CYP3A4 0.0908
357 Carbonic anhydrase 2 CA2 0.0894
592 Carbonic anhydrase 4 CA4 0.0849
1024 Solute carrier family 22 member 11 SLC22A11 0.0674
4031 Glutathione S-transferase A1 GSTA1 0.0658
310 Solute carrier family 12 member 2 SLC12A2 0.0635
566 Serotransferrin TF 0.0633
1405 Thiopurine S-methyltransferase TPMT 0.0618
1588 Multidrug resistance protein 1 ABCB1 0.0615
20 Prostaglandin G/H synthase 1 PTGS1 0.0582
4757 Cytochrome P450 2C9 CYP2C9 0.0582
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0546
4924 Cytochrome P450 2C8 CYP2C8 0.0527
896 Glutathione S-transferase Mu 1 GSTM1 0.0502
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0486
290 Prostaglandin G/H synthase 2 PTGS2 0.0485
6016 Cytochrome P450 2C19 CYP2C19 0.0444
6143 Solute carrier family 22 member 7 SLC22A7 0.043
466 Solute carrier family 12 member 3 SLC12A3 0.0401
6024 Cytochrome P450 1A1 CYP1A1 0.0399
4041 Microsomal glutathione S-transferase 2 MGST2 0.0393
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0387
53 Solute carrier family 12 member 5 SLC12A5 0.0361
663 Solute carrier family 12 member 4 SLC12A4 0.0361
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0347
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0336
4119 Cytochrome P450 2D6 CYP2D6 0.0333
4200 Cytochrome P450 1A2 CYP1A2 0.0311
904 Glutathione S-transferase P GSTP1 0.031
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0307
3007 Carbonic anhydrase 12 CA12 0.0298
4205 Carbonic anhydrase 9 CA9 0.0298
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0291
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0275
4118 Cytochrome P450 3A5 CYP3A5 0.0275
118 Organic cation/carnitine transporter 2 SLC22A5 0.0268
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0253
2164 Multidrug resistance-associated protein 4 ABCC4 0.0249
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0247
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0245
304 Solute carrier family 12 member 7 SLC12A7 0.0243
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0243
157 Solute carrier family 12 member 6 SLC12A6 0.0242
2112 Toll-like receptor 9 TLR9 0.0237
6030 Cytochrome P450 2B6 CYP2B6 0.0233
6013 Cytochrome P450 2E1 CYP2E1 0.0231
891 Dihydropteroate synthase folP 0.0207
5359 Dihydropteroate synthase folP 0.0207
7175 Dihydropteroate synthase sulI 0.0207
3947 Xanthine dehydrogenase/oxidase XDH 0.0205
5718 Cytochrome P450 2A6 CYP2A6 0.0199
862 Multidrug resistance-associated protein 1 ABCC1 0.0198
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0192
777 Tumor necrosis factor TNF 0.0191
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0191
468 Cytochrome P450 4A11 CYP4A11 0.0187
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0184
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0176
633 Penicillin-binding proteins 1A/1B pbpA 0.0173
645 Penicillin-binding protein 1A mrcA 0.0172
5805 Penicillin-binding protein 1A ponA 0.0172
6185 Penicillin-binding protein 1A mrcA 0.0172
6799 Penicillin-binding protein 1A pbpA 0.0172
1389 Transforming growth factor beta-1 TGFB1 0.0169
6145 Solute carrier family 22 member 1 SLC22A1 0.0163
3426 Glutamine synthetase glnA 0.0161
3987 Glutamine synthetase GLUL 0.0161
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0159
899 Glutathione S-transferase Mu 3 GSTM3 0.0156
905 Glutathione transferase omega-1 GSTO1 0.0156
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0152
6141 Sodium/bile acid cotransporter SLC10A1 0.0151
543 Penicillin-binding protein 1B mrcB 0.0149
6186 Penicillin-binding protein 1B ponB 0.0149
6822 Penicillin-binding protein 1b pbp1b 0.0149
6844 Penicillin-binding protein 1b pbp1b 0.0149
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0147
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6541 Peptostreptococcal albumin-binding protein pab 0.0142
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0142
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0137
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0134
776 Bile salt export pump ABCB11 0.0132
738 Monocarboxylate transporter 1 SLC16A1 0.0131
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0127
375 SEC14-like protein 3 SEC14L3 0.0127
86 SEC14-like protein 4 SEC14L4 0.0127
4076 Diacylglycerol kinase alpha DGKA 0.0127
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0124
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
283 SEC14-like protein 2 SEC14L2 0.012
275 Arachidonate 5-lipoxygenase ALOX5 0.0119
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0118
338 DNA polymerase UL30 0.0116
379 DNA polymerase UL54 0.0116
697 DNA polymerase ORF28 0.0116
2482 DNA polymerase 43 0.0116
4104 DNA polymerase BALF5 0.0116
6107 Cytochrome P450 3A7 CYP3A7 0.0116
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0113
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0112
3639 Thymidine phosphorylase deoA 0.0111
3936 Thymidine phosphorylase TYMP 0.0111
1 Peptidoglycan synthetase ftsI ftsI 0.011
4155 Peptidoglycan synthetase ftsI ftsI 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
708 Alpha-tocopherol transfer protein TTPA 0.0107
997 Protein kinase C beta type PRKCB 0.0107
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0103
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0103
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0101
1970 Protein kinase C alpha type PRKCA 0.0099
6136 Multidrug resistance-associated protein 5 ABCC5 0.0099
2211 Fatty acid-binding protein, heart FABP3 0.0098
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0098
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0097
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
373 Transthyretin TTR 0.009
6167 Organic solute transporter subunit beta OSTB 0.0089
6166 Organic solute transporter subunit alpha OSTA 0.0089
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0088
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0087
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0087
6144 Solute carrier family 22 member 2 SLC22A2 0.0086
115 Penicillin-binding protein 2 mrdA 0.0086
6069 Penicillin-binding protein 2 mrdA 0.0086
6118 Penicillin-binding protein 2 penA 0.0086
6187 Penicillin-binding protein 2 pbpA 0.0086
6686 Penicillin-binding protein 2 pbp2 0.0086
6939 Penicillin-binding protein 2 mrdA 0.0086
7163 Penicillin-binding protein 2 pbpA 0.0086
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0081
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.008
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.008
810 Heme oxygenase 1 HMOX1 0.008
3391 Heme oxygenase 1 pbsA1 0.008
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
6106 Cytochrome P450 2C18 CYP2C18 0.0078
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0078
465 Calmodulin CALM1 0.0076
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0075
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0073
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0073
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
502 5-hydroxytryptamine 2A receptor HTR2A 0.0071
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.007
2320 Thymidine kinase, cytosolic TK1 0.0069
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0067
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0067
183 Vascular endothelial growth factor A VEGFA 0.0067
36 Insulin receptor INSR 0.0066
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0063
537 ATP synthase delta chain, mitochondrial ATP5D 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
903 Glutathione S-transferase A5 GSTA5 0.0063
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0062
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0061
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0061
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
705 Glutamate receptor 1 GRIA1 0.0061
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0061
482 Glycine receptor subunit alpha-1 GLRA1 0.006
756 Sex hormone-binding globulin SHBG 0.006
5626 Nucleoside diphosphate kinase B NME2 0.006
23 D(1A) dopamine receptor DRD1 0.006
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0059
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0059
833 Organic cation/carnitine transporter 1 SLC22A4 0.0059
3917 Methylenetetrahydrofolate reductase MTHFR 0.0058
6085 Fatty acid-binding protein, intestinal FABP2 0.0056
831 D(2) dopamine receptor DRD2 0.0056
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0056
900 Glutathione S-transferase A4 GSTA4 0.0054
898 Glutathione S-transferase A3 GSTA3 0.0054
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0054
320 5-hydroxytryptamine 1A receptor HTR1A 0.0054
6043 Putative G-protein coupled receptor 44 GPR44 0.0054
4252 Penicillin-binding protein 5 dacA 0.0053
4034 Glutaredoxin-1 GLRX 0.0053
1928 Leukotriene C4 synthase LTC4S 0.0053
4035 Glutathione S-transferase Mu 5 GSTM5 0.0053
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0053
4040 Glutathione peroxidase 7 GPX7 0.0053
906 Glutathione peroxidase 1 GPX1 0.0053
4036 Glutathione peroxidase 6 GPX6 0.0053
4037 Hypothetical protein GPX1 0.0053
4297 Hypothetical protein SP_1951 0.0053
4521 Hypothetical protein BC_2969 0.0053
4540 Hypothetical protein TM_1070 0.0053
4555 Hypothetical protein MT1739 0.0053
4569 Hypothetical protein mshD 0.0053
4578 Hypothetical protein PA3270 0.0053
4747 Hypothetical protein PA3967 0.0053
5177 Hypothetical protein TM_0096 0.0053
5194 Hypothetical protein PA1204 0.0053
5240 Hypothetical protein Rv2991 0.0053
5370 Hypothetical protein TM_1158 0.0053
5710 Hypothetical protein Tb927.5.1360 0.0053
4029 Microsomal glutathione S-transferase 3 MGST3 0.0053
4032 Microsomal glutathione S-transferase 1 MGST1 0.0053
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0053
907 Glutathione peroxidase 2 GPX2 0.0053
4038 Glutathione peroxidase 4 GPX4 0.0053
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0053
910 Epididymal secretory glutathione peroxidase GPX5 0.0053
911 Glutathione peroxidase 3 GPX3 0.0053
4042 Glutathione transferase omega-2 GSTO2 0.0053
4033 S-formylglutathione hydrolase ESD 0.0053
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0053
6149 Solute carrier family 22 member 10 SLC22A10 0.0052
1867 Major prion protein PRNP 0.0052
159 Penicillin-binding protein 2B penA 0.0052
6121 Penicillin-binding protein 2B penA 0.0052
24 Thymidylate synthase TMP1 0.0052
359 Thymidylate synthase TYMS 0.0052
2626 Thymidylate synthase thyA 0.0052
2729 Thymidylate synthase thyA 0.0052
5352 Thymidylate synthase THYA 0.0052
65 Matrix metalloproteinase-9 Not Available 0.0052
244 Angiotensin-converting enzyme ACE 0.0052
438 Taste receptor type 1 member 2 TAS1R2 0.0051
492 Histamine H1 receptor HRH1 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
146 Androgen receptor AR 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
819 Penicillin-binding protein 4 dacB 0.0048
2183 Fatty acid-binding protein, adipocyte FABP4 0.0047
70 Type-1 angiotensin II receptor AGTR1 0.0047
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
707 72 kDa type IV collagenase MMP2 0.0046
1313 Lactoylglutathione lyase GLO1 0.0046
897 Glutathione S-transferase kappa 1 GSTK1 0.0046
459 Retinoic acid receptor RXR-alpha RXRA 0.0046
3319 Hydroxyacylglutathione hydrolase HAGH 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
6207 30S ribosomal protein S14 rpsN 0.0045
6209 30S ribosomal protein S19 rpsS 0.0045
6712 30S ribosomal protein S19 rpsS 0.0045
6726 30S ribosomal protein S19 rpsS 0.0045
3760 Penicillin-binding protein 5 precursor dacA 0.0045
4604 Liver carboxylesterase 1 CES1 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0044
909 Maleylacetoacetate isomerase GSTZ1 0.0044
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0044
6147 Solute carrier family 22 member 3 SLC22A3 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
6148 Multidrug resistance-associated protein 7 ABCC10 0.0043
556 Alpha-1A adrenergic receptor ADRA1A 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0042
844 Epidermal growth factor receptor EGFR 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
408 Riboflavin kinase RFK 0.0041
632 Alpha-1B adrenergic receptor ADRA1B 0.0041
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
6033 High affinity interleukin-8 receptor A CXCR1 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
2165 Glutathione S-transferase Mu 2 GSTM2 0.004
1198 Serum paraoxonase/arylesterase 1 PON1 0.0039
6223 Penicillin-binding protein 1C pbpC 0.0039
207 Glutathione synthetase GSS 0.0038
5269 Glutathione synthetase gshB 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0038
5353 Glutamate decarboxylase alpha gadA 0.0037
901 Glutathione S-transferase Mu 4 GSTM4 0.0037
1714 Mitogen-activated protein kinase 3 MAPK3 0.0037
136 Estrogen receptor ESR1 0.0037
6131 Carbonic anhydrase 14 CA14 0.0035
908 Glutathione S-transferase theta-1 GSTT1 0.0035
380 Cytochrome P450 17A1 CYP17A1 0.0035
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
594 Thyroxine-binding globulin SERPINA7 0.0032
6677 Myelin P2 protein PMP2 0.0032
293 Gamma-glutamyl hydrolase GGH 0.0032
6102 Arylamine N-acetyltransferase 2 NAT2 0.0032
595 Fibrinogen alpha chain FGA 0.0032
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0031
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0031
714 Glutathione reductase, mitochondrial GSR 0.0031
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
1050 Bile salt sulfotransferase SULT2A1 0.003
758 Thyroid hormone receptor alpha THRA 0.003
654 Flavin reductase BLVRB 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
1757 Myeloperoxidase MPO 0.0028
1650 Heme carrier protein 1 SLC46A1 0.0028
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
1898 Cytochrome P450 1B1 CYP1B1 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
1025 Aquaporin-1 AQP1 0.0027
346 Thyroid hormone receptor beta-1 THRB 0.0027
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0027
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
122 P2Y purinoceptor 12 P2RY12 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
822 Aldose reductase AKR1B1 0.0026
4217 Telomerase reverse transcriptase TERT 0.0026
4773 Deoxycytidine kinase DCK 0.0026
3941 Amine oxidase [flavin-containing] A MAOA 0.0025
130 Prostacyclin synthase PTGIS 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
824 Sodium-dependent serotonin transporter SLC6A4 0.0025
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0025
847 Mu-type opioid receptor OPRM1 0.0025
811 Translocator protein TSPO 0.0024
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0024
3923 Cholinesterase BCHE 0.0024
6014 Cytochrome P450 2A13 CYP2A13 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
6231 Pepsin A PGA3 0.0024
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
696 Kappa-type opioid receptor OPRK1 0.0023
4760 Mll3241 protein mll3241 0.0023
3811 Cytochrome P450 19A1 CYP19A1 0.0023
2981 Phospholipase A2, membrane associated PLA2G2A 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
6103 Arylamine N-acetyltransferase 1 NAT1 0.0022
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0022
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0022
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0022
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0022
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0022
6137 Multidrug resistance-associated protein 6 ABCC6 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
2021 Thrombomodulin THBD 0.0021
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
527 Prostacyclin receptor PTGIR 0.0021
6031 Cytochrome P450 3A43 CYP3A43 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
672 Prostaglandin F2-alpha receptor PTGFR 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
768 FK506-binding protein 1A FKBP1A 0.002
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.002
1992 Vitamin D-binding protein GC 0.002
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
869 Estrogen receptor beta ESR2 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0019
1654 Interleukin-1 beta IL1B 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
199 Monocarboxylate transporter 8 SLC16A2 0.0018
5934 Cytochrome P450 26A1 CYP26A1 0.0018
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
6218 Pannexin-1 PANX1 0.0018
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0018
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
33 Cystine/glutamate transporter SLC7A11 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
1507 Cytochrome c CYCS 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0016
2207 Rhodopsin RHO 0.0016
6042 Prostaglandin reductase 2 PTGR2 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
5818 Folate receptor alpha FOLR1 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
162 Retinoic acid receptor gamma-1 RARG 0.0015
494 Caspase-1 CASP1 0.0015
614 Progesterone receptor PGR 0.0015
1792 Tissue-type plasminogen activator PLAT 0.0015
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0015
871 Glucocorticoid receptor NR3C1 0.0014
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0014
273 Apoptosis regulator Bcl-2 BCL2 0.0014
789 Alpha-1D adrenergic receptor ADRA1D 0.0014
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
467 Delta-type opioid receptor OPRD1 0.0013
1656 CYP2B protein CYP2B 0.0013
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
6151 Monocarboxylate transporter 10 SLC16A10 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
2077 Caspase-3 CASP3 0.0013
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0013
6459 Glycodelin PAEP 0.0013
6432 Transporter snf 0.0013
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0013
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0012
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0012
4226 Uridine phosphorylase 2 UPP2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0012
590 5-hydroxytryptamine 2C receptor HTR2C 0.0012
489 Monocarboxylate transporter 2 SLC16A7 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
4225 Uridine phosphorylase 1 UPP1 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0011
318 Alpha-2A adrenergic receptor ADRA2A 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
51 Muscarinic acetylcholine receptor M3 CHRM3 0.001
413 Amidophosphoribosyltransferase PPAT 0.001
2515 Amidophosphoribosyltransferase purF 0.001
3714 Amidophosphoribosyltransferase purF 0.001
617 Muscarinic acetylcholine receptor M2 CHRM2 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.001
103 Muscarinic acetylcholine receptor M1 CHRM1 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
1039 Histone deacetylase 9 HDAC9 0.0009
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
436 5-hydroxytryptamine 2B receptor HTR2B 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
6020 Aldehyde oxidase AOX1 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
1864 RET proto-oncogene RET 0.0009
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0009
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0009
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0009
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0009
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
365 Dihydrofolate reductase DHFR 0.0009
2381 Dihydrofolate reductase DFR1 0.0009
2833 Dihydrofolate reductase Not Available 0.0009
2931 Dihydrofolate reductase folA 0.0009
3544 Dihydrofolate reductase folA 0.0009
3682 Dihydrofolate reductase folA 0.0009
6642 Dihydrofolate reductase folA 0.0009
6756 Dihydrofolate reductase dfrA 0.0009
378 Alpha-2C adrenergic receptor ADRA2C 0.0008
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
629 Alpha-2B adrenergic receptor ADRA2B 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
3587 Gastrotropin FABP6 0.0008
3937 Fatty-acid amide hydrolase FAAH 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0008
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0008
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0008
731 HIV-1 protease HIV-1 protease 0.0008
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0007
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0007
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
228 Beta platelet-derived growth factor receptor PDGFRB 0.0007
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0006
504 Mast/stem cell growth factor receptor KIT 0.0006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0006
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0006
124 Histamine H2 receptor HRH2 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
3810 Catechol O-methyltransferase COMT 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0005
193 Beta-1 adrenergic receptor ADRB1 0.0005
5961 Insulin INS 0.0005
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
528 5-hydroxytryptamine 1E receptor HTR1E 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
716 5-hydroxytryptamine 7 receptor HTR7 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
163 D(1B) dopamine receptor DRD5 0.0004
341 5-hydroxytryptamine 3 receptor HTR3A 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
432 D(4) dopamine receptor DRD4 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
725 5-hydroxytryptamine 1D receptor HTR1D 0.0003
638 D(3) dopamine receptor DRD3 0.0003
885 5-hydroxytryptamine 1B receptor HTR1B 0.0003
4943 Cytochrome c6 petJ 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4942 Diheme cytochrome c napB napB 0.0003
5000 HemO hemO 0.0003
4916 Cyanoglobin glbN 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4984 Neuroglobin NGB 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4961 Hemophore HasA hasA 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4952 Catalase/peroxidase katA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
4920 Peroxidase/catalase katG 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
4990 PpcA ppcA 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
518 Peroxidase/catalase T katG 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
605 Fumarate reductase flavoprotein subunit frdA 0.0002
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0002
3673 Fumarate reductase flavoprotein subunit fccA 0.0002
4912 Fumarate reductase flavoprotein subunit ifcA 0.0002
6549 Fumarate reductase flavoprotein subunit frdA 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
260 Cytochrome P450 51 ERG11 0.0002
761 Cytochrome P450 51 ERG11 0.0002
3163 Cytochrome P450 51 cyp51 0.0002
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
7 Nitric oxide synthase, inducible NOS2 0.0001
291 Nitric-oxide synthase, endothelial NOS3 0.0001
↑