DT-Web: DB00605

Identification

Name

Sulindac

Accession Number

DB00605 (APRD01243)

Type

small molecule

Description

Sulindac is a nonsteroidal anti-inflammatory agent (NSAIA) of the arylalkanoic acid class that is marketed in the U.S. by Merck as Clinoril. Like other NSAIAs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted in vivo to an active sulfide compound by liver enzymes. The sulfide metabolite then undergoes enterohepatic circulation; it is excreted in the bile and then reabsorbed from the intestine. This is thought to help maintain constant blood levels with reduced gastrointestinal side effects. Some studies have shown sulindac to be relatively less irritating to the stomach than other NSAIA's except for drugs of the cyclooxygenase-2 (COX-2) inhibitor class. The exact mechanism of its NSAIA properties is unknown, but it is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

356.411

Groups

approved

Monoisotopic Weight

356.088243305

Pharmacology

Indication

For acute or long-term use in the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder (acute subacromial bursitis/supraspinatus tendinitis), and acute gouty arthritis.

Mechanism of action

Sulindac's exact mechanism of action is unknown. Its antiinflammatory effects are believed to be due to inhibition of both COX-1 and COX-2 which leads to the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

Absorption

Approximately 90% absorbed in humans following oral administration.

Protein binding

At 1 mcg/ml concentrations, approximately 93% sulindac and 98% of its sulfide metabolite are bound to human serum albumin.

Biotransformation

Undergoes two major biotransformations: reversible reduction to the sulfide metabolite, and irreversible oxidation to the sulfone metabolite. Sulindac and its sulfide and sulfone metabolites undergo extensive enterohepatic circulation. Available evidence indicates that the biological activity resides with the sulfide metabolite. Side chain hydroxylation and hydration of the double bond also occur.

Route of elimination

Sulindac is excreted in rat milk; concentrations in milk were 10 to 20% of those levels in plasma. It is not known if sulindac is excreted in human milk. Approximately 50% of the administered dose of sulindac is excreted in the urine with the conjugated sulfone metabolite accounting for the major portion. Hepatic metabolism is an important elimination pathway.

Toxicity

Acute oral toxicity (LD₅₀) in rats is 264 mg/kg. Cases of overdose have been reported and rarely, deaths have occurred. The following signs and symptoms may be observed following overdose: stupor, coma, diminished urine output and hypotension.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	The NSAID, sulindac, may increase the anticoagulant effect of acenocoumarol. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.
Acetylsalicylic acid	Risk of additive toxicity (e.g. bleed risk). Acetylsalicylic acid may decrease the serum concentration of sulindac. Sulindac may counteract the cardioprotective effects of acetylsalicylic acid. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if the interacting agent is initiated, discontinued or dose changed.
Aminosalicylic Acid	Risk of additive toxicity (e.g. bleed risk). Aminosalicylic acid may decrease the serum concentration of sulindac. Consider alternate therapy or monitor for changes in the therapeutic effects of sulindac and adverse effects of both agents if the interacting agent is initiated, discontinued or dose changed.
Azilsartan medoxomil	Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Bumetanide	The NSAID, sulindac, decreases the diuretic and antihypertensive effects of the loop diuretic, bumetanide.
Cholestyramine	The bile acid sequestrant, cholestyramine, may decrease the absorption of the NSAID, sulindac. Monitor for changes in the therapeutic and adverse effects of sulindac if cholestyramine is initiated, discontinued or dose changed. Administering the two agents 2 or more hours apart may reduce, but not eliminate, the risk of this interactions.
Colesevelam	The bile acid sequestrant, colesevelam, may decrease the absorption of the NSAID, sulindac. Sulindac should be administered at least 1 hour before or 4 hours after colesevelam. Monitor for changes in the therapeutic and adverse effects of sulindac if colesevelam is initiated, discontinued or dose changed.
Colestipol	The bile acid sequestrant, colestipol, may decrease the absorption of the NSAID, sulindac. Monitor for changes in the therapeutic and adverse effects of sulindac if colestipol is initiated, discontinued or dose changed. Administering the two agents 2 or more hours apart may reduce, but not eliminate, the risk of this interactions.
Cyclosporine	The NSAID, sulindac, may increase the nephrotoxic effect of cyclosporine. Sulindac may increase the serum concentration of cyclosporine. Consider alternate therapy or monitor for increased cyclosporine levels and nephrotoxicity during concomitant therapy.
Ethacrynic acid	The NSAID, sulindac, may decrease the diuretic and antihypertensive effects of the loop diuretic, ethacryninc acid.
Furosemide	The NSAID, sulindac, may decrease the diuretic and antihypertensive effects of the loop diuretic, furosemide.
Ginkgo biloba	Ginkgo biloba may enhance the anticoagulant effect of sulindac. Increased risk of bleeding, bruising and altered mental status due to CNS bleeds. Concomitant therapy should be avoided.
Ginseng	Ginseng may enhance the anticoagulant effect of sulindac. Increased risk of bleeding, bruising and altered mental status due to CNS bleeds. Concomitant therapy should be avoided.
Ketorolac	May cause additive or synergistic NSAID toxicities (e.g. GI bleeding, renal dysfunction, etc.). Concomitant therapy is contraindicated.
Methotrexate	The NSAID, sulindac, may decrease the clearance methotrexate. Consider alternate therapy, especially in patients receiving high antineoplastic doses of methotrexate. Otherwise, monitor for hematologic and renal toxicities.
Pemetrexed	The NSAID, sulindac, may increase the serum concentration of pemetrexed by decreasing its elimination. This interaction more prevalent in patients with mild to moderate renal insufficiency. Consider alternate therapy or monitor for pemetrexed toxicity during concomitant therapy.
Pralatrexate	NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
S-Adenosylmethionine	S-adenosylmethionine may enhance the anticoagulant effect of sulindac. Increased risk of bleeding, bruising and altered mental status due to CNS bleeds. Concomitant therapy should be avoided.
Salicylate-sodium	Risk of additive toxicity (e.g. bleed risk). Salicylate-sodium may decrease the serum concentration of sulindac. Consider alternate therapy or monitor for changes in the therapeutic effects of sulindac and adverse effects of both agents if the interacting agent is initiated, discontinued or dose changed.
Salsalate	Risk of additive toxicity (e.g. bleed risk). Salsalate may decrease the serum concentration of sulindac. Consider alternate therapy or monitor for changes in the therapeutic effects of sulindac and adverse effects of both agents if the interacting agent is initiated, discontinued or dose changed.
Telmisartan	Concomitant use of Telmisartan and Sulindac may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol	The NSAID, Sulindac, may antagonize the antihypertensive effect of Timolol.
Trandolapril	The NSAID, Sulindac, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Sulindac is initiated, discontinued or dose changed.
Treprostinil	The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Sulindac. Monitor for increased bleeding during concomitant thearpy.
Warfarin	The antiplatelet effects of sulindac may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.

Food Interactions

Not Available

Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	yes
Actions	inhibitor
References	Giuliano F, Warner TD: Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs. Br J Pharmacol. 1999 Apr;126(8):1824-30. - Pubmed Molina MA, Sitja-Arnau M, Lemoine MG, Frazier ML, Sinicrope FA: Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res. 1999 Sep 1;59(17):4356-62. - Pubmed Yip-Schneider MT, Barnard DS, Billings SD, Cheng L, Heilman DK, Lin A, Marshall SJ, Crowell PL, Marshall MS, Sweeney CJ: Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. Carcinogenesis. 2000 Feb;21(2):139-46. - Pubmed Fosslien E: Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Crit Rev Clin Lab Sci. 2000 Oct;37(5):431-502. - Pubmed Taylor MT, Lawson KR, Ignatenko NA, Marek SE, Stringer DE, Skovan BA, Gerner EW: Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Res. 2000 Dec 1;60(23):6607-10. - Pubmed
DTHybrid score	0.6188
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Pharmacological action	unknown
Actions	inhibitor
References	Giuliano F, Warner TD: Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs. Br J Pharmacol. 1999 Apr;126(8):1824-30. - Pubmed Lim JT, Piazza GA, Han EK, Delohery TM, Li H, Finn TS, Buttyan R, Yamamoto H, Sperl GJ, Brendel K, Gross PH, Pamukcu R, Weinstein IB: Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines. Biochem Pharmacol. 1999 Oct 1;58(7):1097-107. - Pubmed Soriano AF, Helfrich B, Chan DC, Heasley LE, Bunn PA Jr, Chou TC: Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. Cancer Res. 1999 Dec 15;59(24):6178-84. - Pubmed Cheng ZJ, Tikkanen I, Vapaatalo H, Mervaala EM: Vascular effects of COX inhibition and AT1 receptor blockade in transgenic rats harboring mouse renin-2 gene. J Physiol Pharmacol. 2002 Dec;53(4 Pt 1):597-613. - Pubmed Cheng ZJ, Finckenberg P, Louhelainen M, Merasto S, Tikkanen I, Vapaatalo H, Mervaala EM: Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27). Eur J Pharmacol. 2003 Feb 14;461(2-3):159-69. - Pubmed
DTHybrid score	0.6728
Aldose reductase
Name	Aldose reductase
Gene Name	AKR1B1
Pharmacological action	unknown
Actions	inhibitor
References	Sharma YR, Vajpayee RB, Bhatnagar R, Mohan M, Azad RV, Kumar M, Nath R: Topical sulindac therapy in diabetic senile cataracts: cataract-IV. Indian J Ophthalmol. 1989 Jul-Sep;37(3):127-33. - Pubmed Crabbe MJ, Freeman G, Halder AB, Bron AJ: The inhibition of bovine lens aldose reductase by Clinoril, its absorption into the human red cell and its effect on human red cell aldose reductase activity. Ophthalmic Res. 1985;17(2):85-9. - Pubmed Chaudhry PS, Cabrera J, Juliani HR, Varma SD: Inhibition of human lens aldose reductase by flavonoids, sulindac and indomethacin. Biochem Pharmacol. 1983 Jul 1;32(13):1995-8. - Pubmed Jacobson M, Sharma YR, Cotlier E, Hollander JD: Diabetic complications in lens and nerve and their prevention by sulindac or sorbinil: two novel aldose reductase inhibitors. Invest Ophthalmol Vis Sci. 1983 Oct;24(10):1426-9. - Pubmed van der Sloot P, Mizisin A, Zochodne D: Sulindac in established experimental diabetes: a follow-up study. Can J Neurol Sci. 1995 Aug;22(3):198-201. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.5463
Mitogen-activated protein kinase 3
Name	Mitogen-activated protein kinase 3
Gene Name	MAPK3
Pharmacological action	unknown
Actions	inhibitor
References	Rice PL, Goldberg RJ, Ray EC, Driggers LJ, Ahnen DJ: Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites. Cancer Res. 2001 Feb 15;61(4):1541-7. - Pubmed Rice PL, Washington M, Schleman S, Beard KS, Driggers LJ, Ahnen DJ: Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Cancer Res. 2003 Feb 1;63(3):616-20. - Pubmed Rice PL, Beard KS, Driggers LJ, Ahnen DJ: Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites. Cancer Res. 2004 Nov 15;64(22):8148-51. - Pubmed Pangburn HA, Kraus H, Ahnen DJ, Rice PL: Sulindac metabolites inhibit epidermal growth factor receptor activation and expression. J Carcinog. 2005 Sep 2;4:16. - Pubmed Rice PL, Peters SL, Beard KS, Ahnen DJ: Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways. Mol Cancer Ther. 2006 Mar;5(3):746-54. - Pubmed
DTHybrid score	0.3434
Peroxisome proliferator-activated receptor delta
Name	Peroxisome proliferator-activated receptor delta
Gene Name	PPARD
Pharmacological action	unknown
Actions	negative modulator
References	He TC, Chan TA, Vogelstein B, Kinzler KW: PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29;99(3):335-45. - Pubmed Babbar N, Ignatenko NA, Casero RA Jr, Gerner EW: Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J Biol Chem. 2003 Nov 28;278(48):47762-75. Epub 2003 Sep 23. - Pubmed Jarvis MC, Gray TJ, Palmer CN: Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line. Oncogene. 2005 Dec 8;24(55):8211-5. - Pubmed Kim DJ, Prabhu KS, Gonzalez FJ, Peters JM: Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Carcinogenesis. 2006 May;27(5):1105-12. Epub 2006 Jan 16. - Pubmed Liou JY, Ghelani D, Yeh S, Wu KK: Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon. Cancer Res. 2007 Apr 1;67(7):3185-91. - Pubmed
DTHybrid score	0.9502
Putative G-protein coupled receptor 44
Name	Putative G-protein coupled receptor 44
Gene Name	GPR44
Pharmacological action	unknown
Actions	antagonist
References	Hata AN, Lybrand TP, Marnett LJ, Breyer RM: Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. Mol Pharmacol. 2005 Mar;67(3):640-7. Epub 2004 Nov 24. - Pubmed
DTHybrid score	0.4133

Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2827
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3834

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed
DTHybrid score	0.3758

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.3758

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.2993
4757	Cytochrome P450 2C9	CYP2C9	0.2439
6016	Cytochrome P450 2C19	CYP2C19	0.1454
4924	Cytochrome P450 2C8	CYP2C8	0.1401
1588	Multidrug resistance protein 1	ABCB1	0.138
4119	Cytochrome P450 2D6	CYP2D6	0.1268
5716	Casein kinase I isoform gamma-2	CSNK1G2	0.1225
6296	Serine/threonine-protein kinase haspin	GSG2	0.1143
6142	Solute carrier family 22 member 8	SLC22A8	0.1072
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0931
6013	Cytochrome P450 2E1	CYP2E1	0.0921
1024	Solute carrier family 22 member 11	SLC22A11	0.0835
6862	Aldo-keto reductase family 1 member B10	AKR1B10	0.0813
4118	Cytochrome P450 3A5	CYP3A5	0.0808
1176	Mitogen-activated protein kinase 1	MAPK1	0.0784
6030	Cytochrome P450 2B6	CYP2B6	0.0701
1771	Cell division control protein 2 homolog	CDK1	0.0664
3321	Cell division control protein 2 homolog	CRK2	0.0664
3959	Cell division protein kinase 4	CDK4	0.0658
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.065
768	FK506-binding protein 1A	FKBP1A	0.0649
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0626
6143	Solute carrier family 22 member 7	SLC22A7	0.0619
5718	Cytochrome P450 2A6	CYP2A6	0.0591
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.058
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0553
2164	Multidrug resistance-associated protein 4	ABCC4	0.0553
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0548
1898	Cytochrome P450 1B1	CYP1B1	0.0546
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.054
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0524
275	Arachidonate 5-lipoxygenase	ALOX5	0.0515
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0509
6107	Cytochrome P450 3A7	CYP3A7	0.0496
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0493
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0463
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0423
862	Multidrug resistance-associated protein 1	ABCC1	0.0407
122	P2Y purinoceptor 12	P2RY12	0.0399
1757	Myeloperoxidase	MPO	0.0395
527	Prostacyclin receptor	PTGIR	0.0352
1569	G1/S-specific cyclin-D1	CCND1	0.0347
3312	Fatty acid-binding protein, brain	FABP7	0.0347
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0342
118	Organic cation/carnitine transporter 2	SLC22A5	0.0327
36	Insulin receptor	INSR	0.0325
6106	Cytochrome P450 2C18	CYP2C18	0.0321
6145	Solute carrier family 22 member 1	SLC22A1	0.0321
6228	Nuclear receptor coactivator 1	NCOA1	0.0318
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.03
1629	Transcription factor AP-1	JUN	0.0295
373	Transthyretin	TTR	0.0286
2240	Cell division protein kinase 2	CDK2	0.0285
404	DNA gyrase subunit A	gyrA	0.0281
6224	DNA gyrase subunit A	gyrA	0.0281
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0281
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0275
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0273
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0256
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0253
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0251
777	Tumor necrosis factor	TNF	0.0238
6144	Solute carrier family 22 member 2	SLC22A2	0.0236
6141	Sodium/bile acid cotransporter	SLC10A1	0.0234
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0229
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0227
891	Dihydropteroate synthase	folP	0.0226
5359	Dihydropteroate synthase	folP	0.0226
7175	Dihydropteroate synthase	sulI	0.0226
6447	Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	0.0225
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0223
738	Monocarboxylate transporter 1	SLC16A1	0.0221
3923	Cholinesterase	BCHE	0.022
759	Free fatty acid receptor 1	FFAR1	0.0218
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0218
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0216
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0215
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0214
6042	Prostaglandin reductase 2	PTGR2	0.021
492	Histamine H1 receptor	HRH1	0.0208
477	DNA topoisomerase 4 subunit A	parC	0.0208
886	DNA topoisomerase 4 subunit A	parC	0.0208
6226	DNA topoisomerase 4 subunit A	parC	0.0208
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0201
3811	Cytochrome P450 19A1	CYP19A1	0.0199
776	Bile salt export pump	ABCB11	0.0198
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0197
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0195
6137	Multidrug resistance-associated protein 6	ABCC6	0.0194
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0191
831	D(2) dopamine receptor	DRD2	0.019
1053	BC269730_2	FADS1	0.0188
1395	Sodium/calcium exchanger 1	SLC8A1	0.0188
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0188
1159	Interleukin-6	IL6	0.0185
864	Gag-Pol polyprotein	gag-pol	0.0184
2237	Gag-Pol polyprotein	gag-pol	0.0184
2326	Gag-Pol polyprotein	gag-pol	0.0184
2451	Gag-Pol polyprotein	gag-pol	0.0184
2901	Gag-Pol polyprotein	gag-pol	0.0184
3165	Gag-Pol polyprotein	gag-pol	0.0184
3722	Gag-Pol polyprotein	gag-pol	0.0184
6306	Gag-Pol polyprotein	gag-pol	0.0184
6624	Gag-Pol polyprotein	gag-pol	0.0184
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0181
817	DNA topoisomerase 2-alpha	TOP2A	0.0181
4604	Liver carboxylesterase 1	CES1	0.0174
633	Penicillin-binding proteins 1A/1B	pbpA	0.0173
645	Penicillin-binding protein 1A	mrcA	0.0172
5805	Penicillin-binding protein 1A	ponA	0.0172
6185	Penicillin-binding protein 1A	mrcA	0.0172
6799	Penicillin-binding protein 1A	pbpA	0.0172
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0172
291	Nitric-oxide synthase, endothelial	NOS3	0.0171
146	Androgen receptor	AR	0.0169
1389	Transforming growth factor beta-1	TGFB1	0.0169
6220	Aryl hydrocarbon receptor	AHR	0.0168
318	Alpha-2A adrenergic receptor	ADRA2A	0.0168
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0167
723	Cytosolic phospholipase A2	PLA2G4A	0.0167
556	Alpha-1A adrenergic receptor	ADRA1A	0.0165
6014	Cytochrome P450 2A13	CYP2A13	0.0161
23	D(1A) dopamine receptor	DRD1	0.0161
468	Cytochrome P450 4A11	CYP4A11	0.016
136	Estrogen receptor	ESR1	0.016
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0158
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0157
1313	Lactoylglutathione lyase	GLO1	0.0157
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0155
672	Prostaglandin F2-alpha receptor	PTGFR	0.0155
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0153
295	Carbonic anhydrase 1	CA1	0.0153
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0152
558	Solute carrier family 12 member 1	SLC12A1	0.0152
592	Carbonic anhydrase 4	CA4	0.015
543	Penicillin-binding protein 1B	mrcB	0.0149
6186	Penicillin-binding protein 1B	ponB	0.0149
6822	Penicillin-binding protein 1b	pbp1b	0.0149
6844	Penicillin-binding protein 1b	pbp1b	0.0149
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0146
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0145
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0144
193	Beta-1 adrenergic receptor	ADRB1	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
3941	Amine oxidase [flavin-containing] A	MAOA	0.0139
3947	Xanthine dehydrogenase/oxidase	XDH	0.0138
833	Organic cation/carnitine transporter 1	SLC22A4	0.0136
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0133
6102	Arylamine N-acetyltransferase 2	NAT2	0.0133
703	NADPH azoreductase	azr	0.0132
357	Carbonic anhydrase 2	CA2	0.0131
6147	Solute carrier family 22 member 3	SLC22A3	0.0131
1507	Cytochrome c	CYCS	0.0127
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0125
824	Sodium-dependent serotonin transporter	SLC6A4	0.0125
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0124
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0123
850	Vasopressin V1b receptor	AVPR1B	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
871	Glucocorticoid receptor	NR3C1	0.012
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0118
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0118
632	Alpha-1B adrenergic receptor	ADRA1B	0.0117
3639	Thymidine phosphorylase	deoA	0.0117
3936	Thymidine phosphorylase	TYMP	0.0117
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0117
338	DNA polymerase	UL30	0.0116
379	DNA polymerase	UL54	0.0116
697	DNA polymerase	ORF28	0.0116
2482	DNA polymerase	43	0.0116
4104	DNA polymerase	BALF5	0.0116
48	Pyridoxal kinase	PDXK	0.0116
33	Cystine/glutamate transporter	SLC7A11	0.0115
6085	Fatty acid-binding protein, intestinal	FABP2	0.0114
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0114
6148	Multidrug resistance-associated protein 7	ABCC10	0.0113
853	Farnesyl pyrophosphate synthetase	FDPS	0.0113
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0111
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0111
1517	Beta-3 adrenergic receptor	ADRB3	0.011
3932	Glutathione S-transferase A2	GSTA2	0.011
2538	6-phospho-beta-glucosidase bglT	bglT	0.011
2393	Maltose-6'-phosphate glucosidase	glvA	0.011
1	Peptidoglycan synthetase ftsI	ftsI	0.011
4155	Peptidoglycan synthetase ftsI	ftsI	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
766	Beta-2 adrenergic receptor	ADRB2	0.011
70	Type-1 angiotensin II receptor	AGTR1	0.0109
185	Vasopressin V1a receptor	AVPR1A	0.0107
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0107
322	Vasopressin V2 receptor	AVPR2	0.0105
613	Atrial natriuretic peptide receptor A	NPR1	0.0105
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0102
6136	Multidrug resistance-associated protein 5	ABCC5	0.0102
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0101
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0101
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0101
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.01
1648	Elastin	ELN	0.0099
1439	Lactotransferrin	LTF	0.0098
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0098
2211	Fatty acid-binding protein, heart	FABP3	0.0098
1881	Hexokinase-1	HK1	0.0098
6149	Solute carrier family 22 member 10	SLC22A10	0.0098
183	Vascular endothelial growth factor A	VEGFA	0.0097
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0097
6033	High affinity interleukin-8 receptor A	CXCR1	0.0096
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0096
459	Retinoic acid receptor RXR-alpha	RXRA	0.0096
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0095
2439	Alpha,alpha-trehalose-phosphate synthase [UDP-forming]	otsA	0.0095
566	Serotransferrin	TF	0.0094
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0094
2499	Tubulin beta-2C chain	TUBB2C	0.0094
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0092
6126	Carbonic anhydrase 7	CA7	0.0092
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0092
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0091
130	Prostacyclin synthase	PTGIS	0.0091
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0091
2503	Phosphomannomutase/phosphoglucomutase	algC	0.009
465	Calmodulin	CALM1	0.009
2853	14 kDa fatty acid-binding protein	Not Available	0.009
4132	Chloride channel protein ClC-Ka	CLCNKA	0.009
16	Adenosine A1 receptor	ADORA1	0.009
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0089
844	Epidermal growth factor receptor	EGFR	0.0088
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0087
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0087
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
2449	Tubulin alpha-3 chain	TUBA1A	0.0086
629	Alpha-2B adrenergic receptor	ADRA2B	0.0086
115	Penicillin-binding protein 2	mrdA	0.0086
6069	Penicillin-binding protein 2	mrdA	0.0086
6118	Penicillin-binding protein 2	penA	0.0086
6187	Penicillin-binding protein 2	pbpA	0.0086
6686	Penicillin-binding protein 2	pbp2	0.0086
6939	Penicillin-binding protein 2	mrdA	0.0086
7163	Penicillin-binding protein 2	pbpA	0.0086
756	Sex hormone-binding globulin	SHBG	0.0086
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0084
482	Glycine receptor subunit alpha-1	GLRA1	0.0084
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0084
790	DNA polymerase subunit alpha B	POLA2	0.0084
2236	Casein kinase II subunit alpha	CSNK2A1	0.0084
789	Alpha-1D adrenergic receptor	ADRA1D	0.0084
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0083
2206	Glucose-6-phosphate isomerase	GPI	0.0082
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0082
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0081
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.008
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0079
823	Fibroblast growth factor receptor 2	FGFR2	0.0078
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0077
1178	Adenosine A2a receptor	ADORA2A	0.0076
4221	Vascular endothelial growth factor	VEGF	0.0075
5816	Cadherin-5	CDH5	0.0075
1656	CYP2B protein	CYP2B	0.0075
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0074
378	Alpha-2C adrenergic receptor	ADRA2C	0.0074
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0074
1650	Heme carrier protein 1	SLC46A1	0.0074
3426	Glutamine synthetase	glnA	0.0073
3987	Glutamine synthetase	GLUL	0.0073
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0073
811	Translocator protein	TSPO	0.0073
5626	Nucleoside diphosphate kinase B	NME2	0.0073
22	30S ribosomal protein S4	rpsD	0.0072
6714	30S ribosomal protein S4	rpsD	0.0072
3939	Amine oxidase [flavin-containing] B	MAOB	0.0072
1050	Bile salt sulfotransferase	SULT2A1	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.007
537	ATP synthase delta chain, mitochondrial	ATP5D	0.007
638	D(3) dopamine receptor	DRD3	0.0069
1192	Sulfotransferase 1A1	SULT1A1	0.0069
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0069
2320	Thymidine kinase, cytosolic	TK1	0.0069
380	Cytochrome P450 17A1	CYP17A1	0.0068
140	30S ribosomal protein S9	rpsI	0.0068
6719	30S ribosomal protein S9	rpsI	0.0068
6725	30S ribosomal protein S9	rpsI	0.0068
273	Apoptosis regulator Bcl-2	BCL2	0.0068
705	Glutamate receptor 1	GRIA1	0.0068
6131	Carbonic anhydrase 14	CA14	0.0067
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0067
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0066
614	Progesterone receptor	PGR	0.0066
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0066
571	Melatonin receptor type 1A	MTNR1A	0.0066
6146	High affinity copper uptake protein 1	SLC31A1	0.0066
362	Melatonin receptor type 1B	MTNR1B	0.0066
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0065
489	Monocarboxylate transporter 2	SLC16A7	0.0065
661	ADP/ATP translocase 1	SLC25A4	0.0064
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
4228	Keratin, type II cytoskeletal 7	KRT7	0.0063
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0062
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0061
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0061
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0061
3823	Cytokine receptor common gamma chain	IL2RG	0.0061
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.006
904	Glutathione S-transferase P	GSTP1	0.006
828	Phenylalanine-4-hydroxylase	PAH	0.006
3109	Phenylalanine-4-hydroxylase	phhA	0.006
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.006
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
5294	Nucleoside diphosphate kinase A	NME1	0.0058
1152	Glycogen phosphorylase, muscle form	PYGM	0.0058
6766	O-GlcNAcase BT_4395	BT_4395	0.0058
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0058
6500	Phospholipase A2	PLA2G1B	0.0057
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0056
737	Mineralocorticoid receptor	NR3C2	0.0056
24	Thymidylate synthase	TMP1	0.0056
359	Thymidylate synthase	TYMS	0.0056
2626	Thymidylate synthase	thyA	0.0056
2729	Thymidylate synthase	thyA	0.0056
5352	Thymidylate synthase	THYA	0.0056
820	Glycine receptor subunit alpha-2	GLRA2	0.0056
908	Glutathione S-transferase theta-1	GSTT1	0.0056
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0056
847	Mu-type opioid receptor	OPRM1	0.0055
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0055
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0054
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0054
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0054
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
4252	Penicillin-binding protein 5	dacA	0.0053
634	Squalene monooxygenase	SQLE	0.0053
7196	Squalene monooxygenase	ERG1	0.0053
1275	Estrogen sulfotransferase	SULT1E1	0.0053
696	Kappa-type opioid receptor	OPRK1	0.0053
724	Interleukin-2 receptor alpha chain	IL2RA	0.0053
717	Interleukin-2 receptor subunit beta	IL2RB	0.0053
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0053
1867	Major prion protein	PRNP	0.0052
159	Penicillin-binding protein 2B	penA	0.0052
6121	Penicillin-binding protein 2B	penA	0.0052
65	Matrix metalloproteinase-9	Not Available	0.0052
244	Angiotensin-converting enzyme	ACE	0.0052
713	Sodium-dependent dopamine transporter	SLC6A3	0.0052
869	Estrogen receptor beta	ESR2	0.0051
438	Taste receptor type 1 member 2	TAS1R2	0.0051
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0051
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0051
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0051
106	Cannabinoid receptor 2	CNR2	0.0051
6103	Arylamine N-acetyltransferase 1	NAT1	0.005
2021	Thrombomodulin	THBD	0.005
6031	Cytochrome P450 3A43	CYP3A43	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0049
260	Cytochrome P450 51	ERG11	0.0049
761	Cytochrome P450 51	ERG11	0.0049
3163	Cytochrome P450 51	cyp51	0.0049
7	Nitric oxide synthase, inducible	NOS2	0.0049
1010	Cytochrome P450 51A1	CYP51A1	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0048
819	Penicillin-binding protein 4	dacB	0.0048
4192	DNA topoisomerase 2-beta	TOP2B	0.0048
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0048
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0048
68	Cannabinoid receptor 1	CNR1	0.0048
432	D(4) dopamine receptor	DRD4	0.0048
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0047
714	Glutathione reductase, mitochondrial	GSR	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
707	72 kDa type IV collagenase	MMP2	0.0046
654	Flavin reductase	BLVRB	0.0046
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
6207	30S ribosomal protein S14	rpsN	0.0045
6209	30S ribosomal protein S19	rpsS	0.0045
6712	30S ribosomal protein S19	rpsS	0.0045
6726	30S ribosomal protein S19	rpsS	0.0045
6122	Carbonic anhydrase 3	CA3	0.0045
4122	Histone deacetylase 2	HDAC2	0.0045
5934	Cytochrome P450 26A1	CYP26A1	0.0045
3760	Penicillin-binding protein 5 precursor	dacA	0.0045
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0045
3601	Dihydropteroate synthase 1	folP1	0.0044
3807	Dihydropteroate synthase 1	folP1	0.0044
3808	Dihydropteroate synthase 2	folP2	0.0044
663	Solute carrier family 12 member 4	SLC12A4	0.0044
53	Solute carrier family 12 member 5	SLC12A5	0.0044
3007	Carbonic anhydrase 12	CA12	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
4205	Carbonic anhydrase 9	CA9	0.0044
504	Mast/stem cell growth factor receptor	KIT	0.0044
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0042
467	Delta-type opioid receptor	OPRD1	0.0042
887	DNA gyrase subunit B	gyrB	0.0041
4150	DNA gyrase subunit B	gyrB	0.0041
6225	DNA gyrase subunit B	gyrB	0.0041
427	Substance-P receptor	TACR1	0.0041
6020	Aldehyde oxidase	AOX1	0.0041
408	Riboflavin kinase	RFK	0.0041
310	Solute carrier family 12 member 2	SLC12A2	0.0041
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.004
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
4103	Proteasome subunit beta type 2	PSMB2	0.004
4102	Proteasome subunit beta type 5	PSMB5	0.004
4101	Proteasome subunit beta type 1	PSMB1	0.004
716	5-hydroxytryptamine 7 receptor	HTR7	0.004
1374	Natriuretic peptides B	NPPB	0.004
1827	Gap junction alpha-1 protein	GJA1	0.004
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.004
1908	Vascular cell adhesion protein 1	VCAM1	0.004
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.004
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.004
232	Corticosteroid-binding globulin	SERPINA6	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
4311	tRNA	TRDMT1	0.0039
4325	tRNA	trmD	0.0039
4328	tRNA	trmD	0.0039
1198	Serum paraoxonase/arylesterase 1	PON1	0.0039
6223	Penicillin-binding protein 1C	pbpC	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0038
1992	Vitamin D-binding protein	GC	0.0037
5353	Glutamate decarboxylase alpha	gadA	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0037
780	Retinoic acid receptor RXR-gamma	RXRG	0.0036
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0036
461	Glycine receptor subunit alpha-3	GLRA3	0.0035
1792	Tissue-type plasminogen activator	PLAT	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0034
444	Alcohol dehydrogenase 1B	ADH1B	0.0034
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0034
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
712	Tubulin alpha chain	TUB1	0.0034
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
4203	Histamine N-methyltransferase	HNMT	0.0034
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0034
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
88	Retinoic acid receptor RXR-beta	RXRB	0.0033
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
162	Retinoic acid receptor gamma-1	RARG	0.0033
2207	Rhodopsin	RHO	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
331	Retinol-binding protein I, cellular	RBP1	0.0032
594	Thyroxine-binding globulin	SERPINA7	0.0032
5328	Prostaglandin F synthase	Tb11.02.2310	0.0032
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0032
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0032
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0032
6677	Myelin P2 protein	PMP2	0.0032
293	Gamma-glutamyl hydrolase	GGH	0.0032
3957	Adenosine deaminase	ADA	0.0032
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0032
163	D(1B) dopamine receptor	DRD5	0.0032
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0031
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0031
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0031
6167	Organic solute transporter subunit beta	OSTB	0.0031
6166	Organic solute transporter subunit alpha	OSTA	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
1618	High affinity nerve growth factor receptor	NTRK1	0.0031
818	50S ribosomal protein L10	rplJ	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
6163	Copper-transporting ATPase 2	ATP7B	0.003
6165	Copper-transporting ATPase 1	ATP7A	0.003
365	Dihydrofolate reductase	DHFR	0.003
2381	Dihydrofolate reductase	DFR1	0.003
2833	Dihydrofolate reductase	Not Available	0.003
2931	Dihydrofolate reductase	folA	0.003
3544	Dihydrofolate reductase	folA	0.003
3682	Dihydrofolate reductase	folA	0.003
6642	Dihydrofolate reductase	folA	0.003
6756	Dihydrofolate reductase	dfrA	0.003
758	Thyroid hormone receptor alpha	THRA	0.003
173	Toll-like receptor 7	TLR7	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
2112	Toll-like receptor 9	TLR9	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
731	HIV-1 protease	HIV-1 protease	0.0029
921	Glutamate receptor 2	GRIA2	0.0029
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0028
569	Retinal dehydrogenase 2	ALDH1A2	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0028
6044	Serum paraoxonase/lactonase 3	PON3	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
6432	Transporter	snf	0.0027
1025	Aquaporin-1	AQP1	0.0027
1405	Thiopurine S-methyltransferase	TPMT	0.0027
346	Thyroid hormone receptor beta-1	THRB	0.0027
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0027
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0027
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
3830	Calreticulin	CALR	0.0027
611	Retinal dehydrogenase 1	ALDH1A1	0.0027
3685	Catabolite gene activator	crp	0.0027
4655	Adenylate cyclase	cyaC	0.0027
4759	Adenylate cyclase	cyaB2	0.0027
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0026
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0026
229	Retinoic acid receptor beta	RARB	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
1864	RET proto-oncogene	RET	0.0026
251	Alcohol dehydrogenase 1A	ADH1A	0.0026
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0026
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0026
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0026
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0026
4217	Telomerase reverse transcriptase	TERT	0.0026
4773	Deoxycytidine kinase	DCK	0.0026
730	Retinoic acid receptor alpha	RARA	0.0026
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0026
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0026
94	5-hydroxytryptamine 4 receptor	HTR4	0.0025
509	Thymidine kinase	TK	0.0025
570	Thymidine kinase	TK	0.0025
2559	Thymidine kinase	TK	0.0025
3430	Thymidine kinase	tdk	0.0025
3518	Thymidine kinase	TK	0.0025
5301	Thymidine kinase	tdk	0.0025
5771	Thymidine kinase	ORF36	0.0025
7009	Thymidine kinase	ORF36	0.0025
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
124	Histamine H2 receptor	HRH2	0.0025
6034	Hydroxyindole O-methyltransferase	ASMT	0.0025
6182	Cytochrome P450 2J2	CYP2J2	0.0025
6035	Nuclear receptor ROR-beta	RORB	0.0025
6036	Eosinophil peroxidase	EPX	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
976	Platelet glycoprotein IX	GP9	0.0025
1039	Histone deacetylase 9	HDAC9	0.0025
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0025
4120	NADPH--cytochrome P450 reductase	POR	0.0025
896	Glutathione S-transferase Mu 1	GSTM1	0.0025
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0024
400	Coagulation factor IX	F9	0.0024
5461	Coagulation factor IX	F9	0.0024
3814	Complement C1r subcomponent	C1R	0.0024
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0024
4992	Cytochrome c peroxidase	Not Available	0.0024
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0024
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6231	Pepsin A	PGA3	0.0024
6070	Nischarin	NISCH	0.0024
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
2249	Aspartate aminotransferase	aspC	0.0023
2671	Aspartate aminotransferase	aspC	0.0023
5490	Aspartate aminotransferase	Not Available	0.0023
814	Ryanodine receptor 1	RYR1	0.0023
4760	Mll3241 protein	mll3241	0.0023
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0022
604	Vitamin K-dependent protein Z	PROZ	0.0022
3937	Fatty-acid amide hydrolase	FAAH	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
997	Protein kinase C beta type	PRKCB	0.0022
84	Nuclear receptor 0B1	NR0B1	0.0022
1525	Heparin-binding growth factor 2	FGF2	0.0022
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
26	Vascular endothelial growth factor receptor 3	FLT4	0.0022
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0022
765	Indoleamine 2,3-dioxygenase	IDO1	0.0022
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0022
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0022
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0022
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0021
1196	Complement decay-accelerating factor	CD55	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0021
4210	Toll-like receptor 4	TLR4	0.0021
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
32	Vascular endothelial growth factor receptor 1	FLT1	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
1970	Protein kinase C alpha type	PRKCA	0.0021
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.002
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.002
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.002
268	Adenosine A2b receptor	ADORA2B	0.002
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.002
422	Vitamin K-dependent protein C	PROC	0.002
1245	Vitamin K-dependent protein S	PROS1	0.002
859	Cellular retinoic acid-binding protein 2	CRABP2	0.002
517	Alcohol dehydrogenase 1C	ADH1C	0.002
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.002
2408	Tyrosine-protein kinase SYK	SYK	0.002
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.002
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.002
936	Ephrin type-A receptor 2	EPHA2	0.002
5346	Oxidoreductase, aldo/keto reductase family	TM_1009	0.002
5326	Oxidoreductase, short chain dehydrogenase/reductase family	TM_0441	0.002
5330	General stress protein 69	yhdN	0.0019
5322	Oxidoreductase ydhF	ydhF	0.0019
5157	Dehydrogenase/reductase SDR family member 11	DHRS11	0.0019
1243	Cathepsin D	CTSD	0.0019
5332	MtdA bifunctional protein	mtdA	0.0019
3778	NAD(P) transhydrogenase subunit beta	pntB	0.0019
4403	Protein iolS	iolS	0.0019
5343	NADP-dependent fatty aldehyde dehydrogenase	aldH	0.0019
3772	3-oxoacyl-[acyl-carrier-protein] reductase	fabG	0.0019
5342	NADH-dependent butanol dehydrogenase, putative	TM_0820	0.0019
5333	Alcohol dehydrogenase, iron-containing	TM_0920	0.0019
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0019
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0019
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0019
666	NADP-dependent malic enzyme	ME1	0.0019
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0019
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0019
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0019
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0019
867	Penicillin-binding protein 3	pbpC	0.0019
6119	Penicillin-binding protein 3	pbp3	0.0019
7154	Penicillin-binding protein 3	pbp3	0.0019
7157	Penicillin-binding protein 3	LMHCC_2184	0.0019
7162	Penicillin-binding protein 3	pbpB	0.0019
7172	Penicillin-binding protein 3	pbp3	0.0019
581	Cytochrome P450 2R1	CYP2R1	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
4226	Uridine phosphorylase 2	UPP2	0.0019
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0019
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0019
1654	Interleukin-1 beta	IL1B	0.0019
284	DNA-directed RNA polymerase beta chain	rpoB	0.0019
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0019
518	Peroxidase/catalase T	katG	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5787	Angiopoietin-1 receptor	TEK	0.0019
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0019
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0019
199	Monocarboxylate transporter 8	SLC16A2	0.0018
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0018
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0018
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0018
239	Coagulation factor X	F10	0.0018
857	Malate dehydrogenase, mitochondrial	MDH2	0.0018
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0018
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0018
4225	Uridine phosphorylase 1	UPP1	0.0018
6218	Pannexin-1	PANX1	0.0018
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0018
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0018
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0018
5590	N utilization substance protein B homolog	nusB	0.0018
5588	Cell division protein FtsY	TM_0570	0.0018
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0018
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0018
2300	Lysozyme	E	0.0018
3633	Lysozyme	R	0.0018
5597	Lysozyme	17	0.0018
5587	Iron(III)-binding periplasmic protein	fbpA	0.0018
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0018
5591	Complement component C8 gamma chain	C8G	0.0018
2838	Ribose-5-phosphate isomerase A	rpiA	0.0018
2952	Ribose-5-phosphate isomerase A	rpiA	0.0018
5595	Ribose-5-phosphate isomerase A	rpiA	0.0018
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0018
5593	Transferase	Not Available	0.0018
4695	UPF0124 protein yfiH	yfiH	0.0018
5060	Intron-associated endonuclease 1	ITEVIR	0.0018
4375	Glutamine synthetase 1	glnA1	0.0018
5575	Short tail fiber protein	12	0.0018
5581	Beta-fructosidase	bfrA	0.0018
5600	Pyruvate decarboxylase	pdc	0.0018
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0018
5580	Hexon protein	PII	0.0017
5574	Invasin	YPTB1668	0.0017
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0017
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
1291	cAMP response element-binding protein	CREB1	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
2375	ADP-L-glycero-D-manno-heptose-6-epimerase	hldD	0.0017
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0017
5073	Ferredoxin--NADP reductase	petH	0.0017
5076	Ferredoxin--NADP reductase	fpr	0.0017
5119	Ferredoxin--NADP reductase	petH	0.0017
5121	Ferredoxin--NADP reductase	fpr	0.0017
4582	Putative pteridine reductase 2	ptr2	0.0017
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0017
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0017
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0017
2305	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	0.0017
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0017
989	L-xylulose reductase	DCXR	0.0017
2636	Shikimate dehydrogenase	aroE	0.0017
3515	Shikimate dehydrogenase	aroE	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
3446	NADP-dependent alcohol dehydrogenase	adh	0.0017
2286	Isocitrate dehydrogenase [NADP]	icd	0.0017
2302	Isocitrate dehydrogenase [NADP]	icd	0.0017
2771	Isocitrate dehydrogenase [NADP]	icd	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0017
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0017
407	Vascular endothelial growth factor receptor 2	KDR	0.0017
76	Nitric-oxide synthase, brain	NOS1	0.0017
413	Amidophosphoribosyltransferase	PPAT	0.0017
2515	Amidophosphoribosyltransferase	purF	0.0017
3714	Amidophosphoribosyltransferase	purF	0.0017
1830	5'-nucleotidase	NT5E	0.0016
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0016
798	Osteocalcin	BGLAP	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0016
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0016
751	Potassium channel subfamily K member 6	KCNK6	0.0016
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
474	Acetylcholinesterase	ACHE	0.0016
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0016
5818	Folate receptor alpha	FOLR1	0.0016
6297	Prostaglandin reductase 1	PTGR1	0.0016
4531	Putative ketoacyl reductase	actIII	0.0016
3062	Aspartate-semialdehyde dehydrogenase	asd	0.0016
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0015
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0015
627	11-cis retinol dehydrogenase	RDH5	0.0015
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0015
494	Caspase-1	CASP1	0.0015
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0015
3729	Citrate synthase	gltA	0.0015
4575	Citrate synthase	cit	0.0015
4580	Citrate synthase	gltA	0.0015
3132	Tryptophan synthase alpha chain	trpA	0.0015
6568	Tryptophan synthase alpha chain	trpA	0.0015
5006	RNASE4 protein	RNASE4	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
4533	Glyoxalase family protein	BC_1747	0.0015
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0015
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0015
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0015
2555	Pol polyprotein	pol	0.0015
3242	Pol polyprotein	gag-pol	0.0015
3471	Pol polyprotein	gag-pro-pol	0.0015
5256	Pol polyprotein	pol	0.0015
6469	Pol polyprotein	gag-pol	0.0015
6565	Pol polyprotein	Not Available	0.0015
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0015
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0015
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0015
369	Coagulation factor VII	F7	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
2675	Pteridine reductase 1	PTR1	0.0015
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0015
1124	Sepiapterin reductase	SPR	0.0015
172	Potassium channel subfamily K member 1	KCNK1	0.0015
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0015
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0014
2521	Cell division protein ftsZ	ftsZ	0.0014
3301	Cell division protein ftsZ	ftsZ	0.0014
2149	Angiogenin	ANG	0.0014
2603	Beta-lactamase II	blm	0.0014
3583	6-phosphogluconolactonase	pgl	0.0014
2159	Quinone oxidoreductase	CRYZ	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0014
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0014
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0014
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0013
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0013
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0013
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0013
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0013
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0013
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0013
856	Vitamin D3 receptor	VDR	0.0013
3810	Catechol O-methyltransferase	COMT	0.0013
3486	Fumarate hydratase class II	fumC	0.0013
2942	Sialidase	nanH	0.0013
3546	Sialidase	nedA	0.0013
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0013
6151	Monocarboxylate transporter 10	SLC16A10	0.0013
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0013
2077	Caspase-3	CASP3	0.0013
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0013
6459	Glycodelin	PAEP	0.0013
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0013
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
267	Plasminogen activator inhibitor 1	SERPINE1	0.0012
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0012
1123	Eosinophil cationic protein	RNASE3	0.0012
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0012
2697	Uridine-cytidine kinase 2	UCK2	0.0012
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0012
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0012
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0012
2452	Tryptophanyl-tRNA synthetase	trpS	0.0012
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0012
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0012
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0012
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0012
702	UMP-CMP kinase	CMPK1	0.0012
5579	Carboxypeptidase B	CPB1	0.0012
4943	Cytochrome c6	petJ	0.0011
4954	Soluble cytochrome b558	Not Available	0.0011
4905	Cytochrome c2	Not Available	0.0011
4939	Cytochrome c2	cycA	0.0011
4964	Cytochrome c2	cycA	0.0011
4979	Cytochrome c2	cycA	0.0011
6673	Cytochrome c2	cycA	0.0011
4984	Neuroglobin	NGB	0.0011
4994	Hemoglobin-like protein HbO	glbO	0.0011
4934	Cytochrome c-551	nirM	0.0011
5218	Cytochrome c-551	nirM	0.0011
4942	Diheme cytochrome c napB	napB	0.0011
4947	Bacterial hemoglobin	vhb	0.0011
4925	Cytochrome c-type protein SHP	shp	0.0011
4916	Cyanoglobin	glbN	0.0011
4998	Hemoglobin-like protein yjbI	yjbI	0.0011
4975	Cytochrome c-556	RPA3973	0.0011
4915	Cytochrome c-550	psbV	0.0011
4959	Cytochrome c-550	psbV	0.0011
5216	Cytochrome c-550	psbV	0.0011
4961	Hemophore HasA	hasA	0.0011
5000	HemO	hemO	0.0011
4936	Cytochrome c2 iso-2	Not Available	0.0011
4981	Iron-starvation protein PigA	pigA	0.0011
4910	Cytoglobin	CYGB	0.0011
3116	Bacterioferritin	bfr	0.0011
4906	Bacterioferritin	bfr	0.0011
4965	Bacterioferritin	bfr	0.0011
4909	CooA protein	cooA	0.0011
4904	Cytochrome c family protein	GSU1996	0.0011
4976	Apocytochrome f	petA	0.0011
6407	Apocytochrome f	petA	0.0011
4935	Cytochrome c-554	cycA1	0.0011
4907	Cytochrome c-L	moxG	0.0011
6865	Cytochrome c-L	moxG	0.0011
4971	Nonaheme cytochrome c	hmcA	0.0011
4937	Cytochrome oxidase subunit II	rcoxA	0.0011
4764	Cytochrome P450 165C4	CYP165C4	0.0011
4989	Cytochrome c551 peroxidase	ccp	0.0011
5222	Cytochrome c551 peroxidase	ccpA	0.0011
4931	Cytochrome P450 167A1	CYP167A1	0.0011
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0011
4999	Cytochrome P450 165B3	CYP165B3	0.0011
4972	P450cin	cinA	0.0011
4960	Putative cytochrome P450-family protein	SCO7417	0.0011
4993	Hydroxylamine oxidoreductase	hao1	0.0011
4903	Methyl-accepting chemotaxis protein	Tar4	0.0011
4952	Catalase/peroxidase	katA	0.0011
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0011
4922	Cytochrome c, putative	SO_4144	0.0011
3093	Catalase HPII	katE	0.0011
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0011
3384	Macrophage migration inhibitory factor	MIF	0.0011
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0011
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0011
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
6221	Steroid hormone receptor ERR1	ESRRA	0.0011
563	Thyroid peroxidase	TPO	0.0011
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0011
411	Glycine N-methyltransferase	GNMT	0.0011
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0011
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0011
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0011
4237	50S ribosomal protein L22	rplV	0.001
345	Plasma retinol-binding protein	RBP4	0.001
128	Adenine phosphoribosyltransferase	APRT	0.001
810	Heme oxygenase 1	HMOX1	0.001
3391	Heme oxygenase 1	pbsA1	0.001
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.001
164	Histamine H4 receptor	HRH4	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
1353	DNA topoisomerase 1	TOP1	0.0009
3552	DNA topoisomerase 1	topA	0.0009
54	Prothrombin	F2	0.0009
233	Potassium channel subfamily K member 2	KCNK2	0.0009
469	Annexin A1	ANXA1	0.0009
5682	Ribonuclease pancreatic	RNASE1	0.0009
3809	Estrogen-related receptor gamma	ESRRG	0.0009
4920	Peroxidase/catalase	katG	0.0009
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0009
1268	Neuropeptide S receptor	NPSR1	0.0009
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0009
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0009
4923	Cytochrome c3	DvMF_2499	0.0009
4945	Cytochrome c3	Not Available	0.0009
4949	Cytochrome c3	DVU_3171	0.0009
4968	Cytochrome c3	cytc3	0.0009
4997	Cytochrome c3	SO_2727	0.0009
5219	Cytochrome c3	cyd	0.0009
4948	Cytochrome c-553	Not Available	0.0009
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0009
2119	Cytochrome b5	CYB5A	0.0009
3189	High-molecular-weight cytochrome c	hmcA	0.0009
4037	Hypothetical protein	GPX1	0.0009
4297	Hypothetical protein	SP_1951	0.0009
4521	Hypothetical protein	BC_2969	0.0009
4540	Hypothetical protein	TM_1070	0.0009
4555	Hypothetical protein	MT1739	0.0009
4569	Hypothetical protein	mshD	0.0009
4578	Hypothetical protein	PA3270	0.0009
4747	Hypothetical protein	PA3967	0.0009
5177	Hypothetical protein	TM_0096	0.0009
5194	Hypothetical protein	PA1204	0.0009
5240	Hypothetical protein	Rv2991	0.0009
5370	Hypothetical protein	TM_1158	0.0009
5710	Hypothetical protein	Tb927.5.1360	0.0009
4902	Nine-heme cytochrome c	Ddes_2038	0.0009
4990	PpcA	ppcA	0.0008
4289	Cytochrome P450	TT_P0059	0.0008
6262	Cytochrome P450	staP	0.0008
3570	Cytochrome P450 152A1	cypC	0.0008
4988	Sulfite oxidase, mitochondrial	SUOX	0.0008
1184	Interferon beta	IFNB1	0.0008
2915	Sensor protein fixL	fixL	0.0008
4944	Sensor protein fixL	fixL	0.0008
3375	Acidic cytochrome c3	Not Available	0.0008
4385	Cytochrome c'	Not Available	0.0008
4967	Cytochrome c'	cycA	0.0008
5038	Cytochrome c'	Not Available	0.0008
5223	Cytochrome c'	cycP	0.0008
4813	Heme oxygenase	hmuO	0.0008
5769	Heme oxygenase	Not Available	0.0008
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0008
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0008
2230	Catalase	CAT	0.0008
3249	Catalase	katA	0.0008
3625	Catalase	katA	0.0008
4539	Catalase	katA	0.0008
4941	Catalase	katB	0.0008
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0008
3587	Gastrotropin	FABP6	0.0008
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0008
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6073	Potassium channel subfamily K member 9	KCNK9	0.0008
6072	Potassium channel subfamily K member 3	KCNK3	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
3670	Soluble cytochrome b562 precursor	cybC	0.0007
3411	Cytochrome P450 121	cyp121	0.0007
2617	Nitric oxide synthase oxygenase	nos	0.0007
2701	Nitric oxide synthase oxygenase	nos	0.0007
3291	Cytochrome c-552	cycA	0.0007
4927	Cytochrome c-552	nrfA	0.0007
4938	Cytochrome c-552	cycA	0.0007
4953	Cytochrome c-552	nrfA	0.0007
5217	Cytochrome c-552	cycM	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
3102	Flavohemoprotein	hmp	0.0007
4969	Flavohemoprotein	hmp	0.0007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
3127	Nitrite reductase	nirS	0.0007
3284	Nitrite reductase	nirS	0.0007
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
3221	Cytochrome c4	cc4	0.0007
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
442	Envelope glycoprotein	gp41	0.0006
4859	Envelope glycoprotein	env	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
4608	Putative cytochrome P450	SCO1207	0.0006
4963	Putative cytochrome P450	SCO2884	0.0006
6254	Putative cytochrome P450	SCO6998	0.0006
358	Cystathionine beta-synthase	CBS	0.0006
693	Hemoglobin subunit beta	HBB	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
816	Biliverdin reductase A	BLVRA	0.0006
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0006
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0006
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0006
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0005
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0005
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0005
2430	Chondroitinase B	cslB	0.0005
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0005
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0005
328	Sorbitol dehydrogenase	SORD	0.0005
597	Dihydropteridine reductase	QDPR	0.0005
396	Alcohol dehydrogenase 4	ADH4	0.0005
6268	Hydroxyacid oxidase 1	HAO1	0.0005
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0005
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0005
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0005
77	L-lactate dehydrogenase B chain	LDHB	0.0005
12	Alcohol dehydrogenase class 3	ADH5	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
153	Dopamine beta-hydroxylase	DBH	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0005
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0005
473	L-lactate dehydrogenase A chain	LDHA	0.0005
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0005
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0005
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0005
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0005
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0005
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0005
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0005
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0005
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0005
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0005
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0005
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0005
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0005
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0005
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0005
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0005
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0005
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0005
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0005
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0005
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0005
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0005
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0005
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0005
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0005
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0005
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0005
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0005
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0005
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0005
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0005
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0005
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0005
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0005
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0005
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0005
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0005
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0005
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0005
167	L-lactate dehydrogenase C chain	LDHC	0.0005
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0005
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0005
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0005
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0005
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0005
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0005
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0005
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0005
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0005
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0005
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0005
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0005
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0005
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0005
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0005
729	GDP-L-fucose synthetase	TSTA3	0.0005
3463	GDP-L-fucose synthetase	fcl	0.0005
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0005
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0005
711	UDP-glucose 6-dehydrogenase	UGDH	0.0005
3672	UDP-glucose 6-dehydrogenase	hasB	0.0005
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0005
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0005
107	C-4 methylsterol oxidase	SC4MOL	0.0005
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0005
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0005
206	3-keto-steroid reductase	HSD17B7	0.0005
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0005
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0005
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0005
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0005
643	Peroxisomal bifunctional enzyme	EHHADH	0.0005
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0005
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0005
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0005
34	7-dehydrocholesterol reductase	DHCR7	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
2298	Cytochrome P450-cam	camC	0.0005
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0005
5961	Insulin	INS	0.0005
13	Aminomethyltransferase, mitochondrial	AMT	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
6755	Poliovirus receptor	PVR	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0004
165	FL cytokine receptor	FLT3	0.0004
626	Cysteine dioxygenase type 1	CDO1	0.0004
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0004
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0004
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
6026	Alcohol dehydrogenase 6	ADH6	0.0004
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0004
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
6524	Protein tonB	tonB	0.0004
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
279	Tyrosinase	TYR	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
952	Dipeptidyl peptidase 4	DPP4	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00605 - Sulindac

Targets

Enzymes

Transporters

Carriers

Predictions