DT-Web

DB00887 - Bumetanide


Identification
Name Bumetanide
Accession Number DB00887 (APRD00294)
Type small molecule
Description A sulfamyl diuretic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 364.416
Groups approved
Monoisotopic Weight 364.10929245
Pharmacology
Indication For the treatment of edema associated with congestive heart failure, hepatic and renal disease including the nephrotic syndrome.
Mechanism of action Bumetanide interferes with renal cAMP and/or inhibits the sodium-potassium ATPase pump. Bumetanide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis.
Absorption Bumetanide is completely absorbed (80%), and the absorption is not altered when taken with food. Bioavailability is almost complete.
Protein binding 97%
Biotransformation 45% is secreted unchanged. Urinary and biliary metabolites are formed by oxidation of the N-butyl side chain.
Route of elimination Oral administration of carbon-14 labeled Bumex to human volunteers revealed that 81% of the administered radioactivity was excreted in the urine, 45% of it as unchanged drug. Biliary excretion of Bumex amounted to only 2% of the administered dose.
Toxicity Overdosage can lead to acute profound water loss, volume and electrolyte depletion, dehydration, reduction of blood volume and circulatory collapse with a possibility of vascular thrombosis and embolism. Electrolyte depletion may be manifested by weakness, dizziness, mental confusion, anorexia, lethargy, vomiting and cramps. Treatment consists of replacement of fluid and electrolyte losses by careful monitoring of the urine and electrolyte output and serum electrolyte levels.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin Increased ototoxicity
Cisplatin Increased ototoxicity
Colesevelam Bile acid sequestrants such as colesevelam may decrease the absorption of loop diuretics such as bumetanide. Monitor for decreased serum concentrations/therapeutic effects of loop diuretics if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Deslanoside Possible electrolyte variations and arrhythmias
Digitoxin Possible electrolyte variations and arrhythmias
Digoxin Possible electrolyte variations and arrhythmias
Gentamicin Increased ototoxicity
Ginseng Ginseng may decrease the therapeutic effect of diuretic, bumetanide.
Ibuprofen The NSAID, ibuprofen, may antagonize the diuretic and antihypertensive effects of the loop diuretic, bumetanide.
Indomethacin The NSAID, indomethacin, may decrease the diuretic and antihypertensive effects of the loop diuretic, bumetanide.
Kanamycin Increased ototoxicity
Netilmicin Increased ototoxicity
Streptomycin Increased ototoxicity
Sulindac The NSAID, sulindac, decreases the diuretic and antihypertensive effects of the loop diuretic, bumetanide.
Tobramycin Increased ototoxicity
Trandolapril The loop diuretic, Bumetanide, may increase the hypotensive effect of Trandolapril. Bumetanide may also increase the nephrotoxicity of Trandolapril.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Food Interactions
  • Take with food to reduce irritation.

Targets


Solute carrier family 12 member 1
Name Solute carrier family 12 member 1
Gene Name SLC12A1
Pharmacological action yes
Actions inhibitor
References
  • Thakker RV: Chloride channels in renal disease. Adv Nephrol Necker Hosp. 1999;29:289-98. - Pubmed
  • Karolyi L, Koch MC, Grzeschik KH, Seyberth HW: The molecular genetic approach to - Bartter's syndrome
  • Thakker RV: The role of renal chloride channel mutations in kidney stone disease and nephrocalcinosis. Curr Opin Nephrol Hypertens. 1998 Jul;7(4):385-8. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Long P, Mercer A, Begum R, Stephens GJ, Sihra TS, Jovanovic JN: Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. J Biol Chem. 2009 Mar 27;284(13):8726-37. Epub 2009 Jan 13. - Pubmed
DTHybrid score 0.8846
Solute carrier family 12 member 2
Name Solute carrier family 12 member 2
Gene Name SLC12A2
Pharmacological action yes
Actions inhibitor
References
  • Panet R, Marcus M, Atlan H: Overexpression of the Na(+)/K(+)/Cl(-) cotransporter gene induces cell proliferation and phenotypic transformation in mouse fibroblasts. J Cell Physiol. 2000 Jan;182(1):109-18. - Pubmed
  • Evans RL, Park K, Turner RJ, Watson GE, Nguyen HV, Dennett MR, Hand AR, Flagella M, Shull GE, Melvin JE: Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. J Biol Chem. 2000 Sep 1;275(35):26720-6. - Pubmed
  • Wall SM, Fischer MP, Mehta P, Hassell KA, Park SJ: Contribution of the Na+-K+-2Cl- cotransporter NKCC1 to Cl- secretion in rat OMCD. Am J Physiol Renal Physiol. 2001 May;280(5):F913-21. - Pubmed
  • Akar F, Jiang G, Paul RJ, O'Neill WC: Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle. Am J Physiol Cell Physiol. 2001 Aug;281(2):C579-84. - Pubmed
  • Jiang G, Klein JD, O'Neill WC: Growth factors stimulate the Na-K-2Cl cotransporter NKCC1 through a novel Cl(-)-dependent mechanism. Am J Physiol Cell Physiol. 2001 Dec;281(6):C1948-53. - Pubmed
DTHybrid score 0.6316
Solute carrier family 12 member 4
Name Solute carrier family 12 member 4
Gene Name SLC12A4
Pharmacological action yes
Actions inhibitor
References
  • Jean-Xavier C, Pflieger JF, Liabeuf S, Vinay L: Inhibitory postsynaptic potentials in lumbar motoneurons remain depolarizing after neonatal spinal cord transection in the rat. J Neurophysiol. 2006 Nov;96(5):2274-81. Epub 2006 Jun 28. - Pubmed
  • Reid KH, Guo SZ, Iyer VG: Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats. Brain Res. 2000 May 2;864(1):134-7. - Pubmed
DTHybrid score 0.5794
Solute carrier family 12 member 5
Name Solute carrier family 12 member 5
Gene Name SLC12A5
Pharmacological action yes
Actions inhibitor
References
  • Reid KH, Guo SZ, Iyer VG: Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats. Brain Res. 2000 May 2;864(1):134-7. - Pubmed
DTHybrid score 0.5795
Cystic fibrosis transmembrane conductance regulator
Name Cystic fibrosis transmembrane conductance regulator
Gene Name CFTR
Pharmacological action unknown
Actions antagonist
References
  • Reddy MM, Quinton PM: Bumetanide blocks CFTR GCl in the native sweat duct. Am J Physiol. 1999 Jan;276(1 Pt 1):C231-7. - Pubmed
DTHybrid score 0.4714

Enzymes


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Actions inducer
References
  • Cheng HF, Wang JL, Zhang MZ, McKanna JA, Harris RC: Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride. J Clin Invest. 2000 Sep;106(5):681-8. - Pubmed
DTHybrid score 0.5181

Transporters


Sodium/bile acid cotransporter
Name Sodium/bile acid cotransporter
Gene Name SLC10A1
Actions substrate,inhibitor
References
  • Hagenbuch B, Stieger B, Foguet M, Lubbert H, Meier PJ: Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10629-33. - Pubmed
  • Platte HD, Honscha W, Schuh K, Petzinger E: Functional characterization of the hepatic sodium-dependent taurocholate transporter stably transfected into an immortalized liver-derived cell line and V79 fibroblasts. Eur J Cell Biol. 1996 May;70(1):54-60. - Pubmed
DTHybrid score 0.2749
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. - Pubmed
  • Uwai Y, Saito H, Hashimoto Y, Inui KI: Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther. 2000 Oct;295(1):261-5. - Pubmed
DTHybrid score 0.5895
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
  • Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score 0.5093
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. - Pubmed
DTHybrid score 0.4107
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions inhibitor
References
  • Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. - Pubmed
DTHybrid score 0.3622
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions substrate
References
  • Horz JA, Honscha W, Petzinger E: Bumetanide is not transported by the Ntcp or by the oatp: evidence for a third organic anion transporter in rat liver cells. Biochim Biophys Acta. 1996 Apr 19;1300(2):114-8. - Pubmed
DTHybrid score 0.362

Predictions


Id Partner name Gene Name Score
157 Solute carrier family 12 member 6 SLC12A6 0.3908
304 Solute carrier family 12 member 7 SLC12A7 0.3875
20 Prostaglandin G/H synthase 1 PTGS1 0.2501
587 Serum albumin ALB 0.1981
1588 Multidrug resistance protein 1 ABCB1 0.1601
4757 Cytochrome P450 2C9 CYP2C9 0.1509
4512 Cytochrome P450 3A4 CYP3A4 0.1413
295 Carbonic anhydrase 1 CA1 0.1279
4924 Cytochrome P450 2C8 CYP2C8 0.1167
357 Carbonic anhydrase 2 CA2 0.1087
2164 Multidrug resistance-associated protein 4 ABCC4 0.1079
776 Bile salt export pump ABCB11 0.1075
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1001
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0996
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.094
6016 Cytochrome P450 2C19 CYP2C19 0.093
466 Solute carrier family 12 member 3 SLC12A3 0.0928
862 Multidrug resistance-associated protein 1 ABCC1 0.0811
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0803
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0739
118 Organic cation/carnitine transporter 2 SLC22A5 0.0725
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0723
4200 Cytochrome P450 1A2 CYP1A2 0.0684
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0681
592 Carbonic anhydrase 4 CA4 0.0652
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.064
6145 Solute carrier family 22 member 1 SLC22A1 0.0598
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.059
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0583
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0569
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0537
4118 Cytochrome P450 3A5 CYP3A5 0.053
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0519
6144 Solute carrier family 22 member 2 SLC22A2 0.0506
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0502
738 Monocarboxylate transporter 1 SLC16A1 0.0498
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0489
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0474
22 30S ribosomal protein S4 rpsD 0.0462
6714 30S ribosomal protein S4 rpsD 0.0462
140 30S ribosomal protein S9 rpsI 0.0435
6719 30S ribosomal protein S9 rpsI 0.0435
6725 30S ribosomal protein S9 rpsI 0.0435
6107 Cytochrome P450 3A7 CYP3A7 0.0423
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0411
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0389
4119 Cytochrome P450 2D6 CYP2D6 0.0388
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0383
6136 Multidrug resistance-associated protein 5 ABCC5 0.0377
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0368
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0351
6013 Cytochrome P450 2E1 CYP2E1 0.0341
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0339
6024 Cytochrome P450 1A1 CYP1A1 0.0337
6149 Solute carrier family 22 member 10 SLC22A10 0.0335
833 Organic cation/carnitine transporter 1 SLC22A4 0.0334
275 Arachidonate 5-lipoxygenase ALOX5 0.0329
633 Penicillin-binding proteins 1A/1B pbpA 0.0301
373 Transthyretin TTR 0.0289
338 DNA polymerase UL30 0.0285
379 DNA polymerase UL54 0.0285
697 DNA polymerase ORF28 0.0285
2482 DNA polymerase 43 0.0285
4104 DNA polymerase BALF5 0.0285
672 Prostaglandin F2-alpha receptor PTGFR 0.0283
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0277
1405 Thiopurine S-methyltransferase TPMT 0.0275
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0272
5353 Glutamate decarboxylase alpha gadA 0.027
645 Penicillin-binding protein 1A mrcA 0.0267
5805 Penicillin-binding protein 1A ponA 0.0267
6185 Penicillin-binding protein 1A mrcA 0.0267
6799 Penicillin-binding protein 1A pbpA 0.0267
6167 Organic solute transporter subunit beta OSTB 0.0265
6166 Organic solute transporter subunit alpha OSTA 0.0265
136 Estrogen receptor ESR1 0.0261
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0251
6148 Multidrug resistance-associated protein 7 ABCC10 0.0248
438 Taste receptor type 1 member 2 TAS1R2 0.0248
543 Penicillin-binding protein 1B mrcB 0.0246
6186 Penicillin-binding protein 1B ponB 0.0246
6822 Penicillin-binding protein 1b pbp1b 0.0246
6844 Penicillin-binding protein 1b pbp1b 0.0246
1757 Myeloperoxidase MPO 0.0245
33 Cystine/glutamate transporter SLC7A11 0.0241
3587 Gastrotropin FABP6 0.0238
3932 Glutathione S-transferase A2 GSTA2 0.0235
6030 Cytochrome P450 2B6 CYP2B6 0.0231
3947 Xanthine dehydrogenase/oxidase XDH 0.0229
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
6147 Solute carrier family 22 member 3 SLC22A3 0.0221
6033 High affinity interleukin-8 receptor A CXCR1 0.0221
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0219
5718 Cytochrome P450 2A6 CYP2A6 0.0214
146 Androgen receptor AR 0.0214
594 Thyroxine-binding globulin SERPINA7 0.0213
244 Angiotensin-converting enzyme ACE 0.0212
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0209
6020 Aldehyde oxidase AOX1 0.0208
1867 Major prion protein PRNP 0.0208
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0205
6012 Tryptophan 2,3-dioxygenase TDO2 0.0205
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0204
3007 Carbonic anhydrase 12 CA12 0.0203
4205 Carbonic anhydrase 9 CA9 0.0203
758 Thyroid hormone receptor alpha THRA 0.0198
2016 Dipeptidase 1 DPEP1 0.0197
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0197
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0197
1898 Cytochrome P450 1B1 CYP1B1 0.0196
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0193
2021 Thrombomodulin THBD 0.019
3811 Cytochrome P450 19A1 CYP19A1 0.0187
6137 Multidrug resistance-associated protein 6 ABCC6 0.0186
1159 Interleukin-6 IL6 0.0185
6207 30S ribosomal protein S14 rpsN 0.0179
6209 30S ribosomal protein S19 rpsS 0.0179
6712 30S ribosomal protein S19 rpsS 0.0179
6726 30S ribosomal protein S19 rpsS 0.0179
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0179
346 Thyroid hormone receptor beta-1 THRB 0.0178
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0174
756 Sex hormone-binding globulin SHBG 0.0174
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0173
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
6043 Putative G-protein coupled receptor 44 GPR44 0.0168
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0168
2249 Aspartate aminotransferase aspC 0.0167
2671 Aspartate aminotransferase aspC 0.0167
5490 Aspartate aminotransferase Not Available 0.0167
115 Penicillin-binding protein 2 mrdA 0.0166
6069 Penicillin-binding protein 2 mrdA 0.0166
6118 Penicillin-binding protein 2 penA 0.0166
6187 Penicillin-binding protein 2 pbpA 0.0166
6686 Penicillin-binding protein 2 pbp2 0.0166
6939 Penicillin-binding protein 2 mrdA 0.0166
7163 Penicillin-binding protein 2 pbpA 0.0166
6085 Fatty acid-binding protein, intestinal FABP2 0.0163
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0163
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0162
4604 Liver carboxylesterase 1 CES1 0.0161
130 Prostacyclin synthase PTGIS 0.0161
273 Apoptosis regulator Bcl-2 BCL2 0.0161
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
737 Mineralocorticoid receptor NR3C2 0.0155
1 Peptidoglycan synthetase ftsI ftsI 0.0155
4155 Peptidoglycan synthetase ftsI ftsI 0.0155
2514 Phosphocarrier protein HPr ptsH 0.0154
5689 Phosphocarrier protein HPr ptsH 0.0154
3602 Anti-sigma F factor antagonist spoIIAA 0.0154
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0154
527 Prostacyclin receptor PTGIR 0.0152
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
6031 Cytochrome P450 3A43 CYP3A43 0.0147
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0145
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0144
723 Cytosolic phospholipase A2 PLA2G4A 0.0144
6106 Cytochrome P450 2C18 CYP2C18 0.0143
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0142
867 Penicillin-binding protein 3 pbpC 0.014
6119 Penicillin-binding protein 3 pbp3 0.014
7154 Penicillin-binding protein 3 pbp3 0.014
7157 Penicillin-binding protein 3 LMHCC_2184 0.014
7162 Penicillin-binding protein 3 pbpB 0.014
7172 Penicillin-binding protein 3 pbp3 0.014
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.014
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
1654 Interleukin-1 beta IL1B 0.0137
1792 Tissue-type plasminogen activator PLAT 0.0137
904 Glutathione S-transferase P GSTP1 0.0136
1130 Lithostathine 1 alpha REG1A 0.0134
4542 Glutaminase 1 glsA1 0.0134
4544 Glutaminase 1 glsA1 0.0134
4318 Siroheme synthase cysG 0.013
2981 Phospholipase A2, membrane associated PLA2G2A 0.0128
6218 Pannexin-1 PANX1 0.0128
6042 Prostaglandin reductase 2 PTGR2 0.0128
3685 Catabolite gene activator crp 0.0127
4655 Adenylate cyclase cyaC 0.0127
4759 Adenylate cyclase cyaB2 0.0127
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0127
5626 Nucleoside diphosphate kinase B NME2 0.0127
3639 Thymidine phosphorylase deoA 0.0127
3936 Thymidine phosphorylase TYMP 0.0127
2320 Thymidine kinase, cytosolic TK1 0.0126
3119 Fimbrial protein pilE1 0.0125
2530 Protein kinase C theta type PRKCQ 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
3923 Cholinesterase BCHE 0.0122
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0122
871 Glucocorticoid receptor NR3C1 0.0121
124 Histamine H2 receptor HRH2 0.0121
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
6151 Monocarboxylate transporter 10 SLC16A10 0.0119
5294 Nucleoside diphosphate kinase A NME1 0.0118
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0117
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0117
3453 Alkaline phosphatase phoA 0.0116
489 Monocarboxylate transporter 2 SLC16A7 0.0114
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0114
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0113
5150 Endo-1,4-beta-xylanase Y xynY 0.0113
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
3312 Fatty acid-binding protein, brain FABP7 0.0113
65 Matrix metalloproteinase-9 Not Available 0.0112
494 Caspase-1 CASP1 0.0111
2503 Phosphomannomutase/phosphoglucomutase algC 0.011
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
183 Vascular endothelial growth factor A VEGFA 0.011
3917 Methylenetetrahydrofolate reductase MTHFR 0.0109
4760 Mll3241 protein mll3241 0.0109
1507 Cytochrome c CYCS 0.0108
6220 Aryl hydrocarbon receptor AHR 0.0107
380 Cytochrome P450 17A1 CYP17A1 0.0107
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0105
6126 Carbonic anhydrase 7 CA7 0.0103
4122 Histone deacetylase 2 HDAC2 0.0103
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0103
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
4217 Telomerase reverse transcriptase TERT 0.0101
3760 Penicillin-binding protein 5 precursor dacA 0.01
1650 Heme carrier protein 1 SLC46A1 0.0099
1313 Lactoylglutathione lyase GLO1 0.0098
777 Tumor necrosis factor TNF 0.0098
199 Monocarboxylate transporter 8 SLC16A2 0.0097
24 Thymidylate synthase TMP1 0.0097
359 Thymidylate synthase TYMS 0.0097
2626 Thymidylate synthase thyA 0.0097
2729 Thymidylate synthase thyA 0.0097
5352 Thymidylate synthase THYA 0.0097
1439 Lactotransferrin LTF 0.0095
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0095
6014 Cytochrome P450 2A13 CYP2A13 0.0094
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0094
3941 Amine oxidase [flavin-containing] A MAOA 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
2077 Caspase-3 CASP3 0.0093
10 Glycogen phosphorylase, liver form PYGL 0.0091
2207 Rhodopsin RHO 0.009
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
819 Penicillin-binding protein 4 dacB 0.009
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
4238 50S ribosomal protein L4 rplD 0.0086
5578 50S ribosomal protein L4 rplD 0.0086
6173 50S ribosomal protein L4 rplD 0.0086
6219 50S ribosomal protein L4 rplD 0.0086
2391 Ferrochelatase hemH 0.0085
6502 Ferrochelatase DKFZp686P18130 0.0085
1591 Ferrochelatase, mitochondrial FECH 0.0085
293 Gamma-glutamyl hydrolase GGH 0.0083
6500 Phospholipase A2 PLA2G1B 0.0082
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0081
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0081
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0081
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0081
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
869 Estrogen receptor beta ESR2 0.0081
5646 Galactokinase GALK1 0.0081
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0081
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0081
5302 TrwB trwB 0.0081
5265 FtsH ftsH 0.0081
2236 Casein kinase II subunit alpha CSNK2A1 0.008
16 Adenosine A1 receptor ADORA1 0.008
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
4237 50S ribosomal protein L22 rplV 0.0079
232 Corticosteroid-binding globulin SERPINA6 0.0079
1178 Adenosine A2a receptor ADORA2A 0.0078
4773 Deoxycytidine kinase DCK 0.0078
703 NADPH azoreductase azr 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
5818 Folate receptor alpha FOLR1 0.0075
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0074
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0074
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0074
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0073
6493 Cytochrome c oxidase subunit 6C COX6C 0.0073
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0073
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0073
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0073
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0073
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0073
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0073
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0073
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0073
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0073
6559 Cytochrome c oxidase subunit 2 ctaC 0.0073
6669 Cytochrome c oxidase subunit 2 ctaC 0.0073
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0073
6558 Cytochrome c oxidase subunit 1 ctaD 0.0073
5312 Kinesin-like protein KIF1A KIF1A 0.0073
614 Progesterone receptor PGR 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0071
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.007
1152 Glycogen phosphorylase, muscle form PYGM 0.007
850 Vasopressin V1b receptor AVPR1B 0.007
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0068
2892 Acetylglutamate kinase argB 0.0068
3550 Acetylglutamate kinase argB 0.0068
2371 Pantothenate kinase coaA 0.0068
2615 Chemotaxis protein cheA cheA 0.0068
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0067
825 Arsenical pump-driving ATPase ASNA1 0.0067
3435 Arsenical pump-driving ATPase arsA 0.0067
1881 Hexokinase-1 HK1 0.0067
3810 Catechol O-methyltransferase COMT 0.0067
731 HIV-1 protease HIV-1 protease 0.0067
2540 Choloylglycine hydrolase cbh 0.0067
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0065
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0065
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0065
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0064
661 ADP/ATP translocase 1 SLC25A4 0.0064
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
2727 S-adenosylmethionine synthetase metK 0.0064
6501 Fatty acid-binding protein, liver FABP1 0.0063
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0062
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0062
6131 Carbonic anhydrase 14 CA14 0.0062
408 Riboflavin kinase RFK 0.0062
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0061
185 Vasopressin V1a receptor AVPR1A 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
492 Histamine H1 receptor HRH1 0.006
322 Vasopressin V2 receptor AVPR2 0.006
4178 DNA repair protein RAD51 homolog 1 RAD51 0.006
5643 General secretion pathway protein E epsE 0.006
3794 Osmolarity sensor protein envZ envZ 0.006
5644 Sensor protein phoQ phoQ 0.006
5641 Rod shape-determining protein MreB TM_0588 0.006
5649 Potassium-transporting ATPase B chain kdpB 0.0059
5642 Chaperone clpB clpB 0.0059
5645 DNA topoisomerase 4 subunit B parE 0.0059
6227 DNA topoisomerase 4 subunit B parE 0.0059
468 Cytochrome P450 4A11 CYP4A11 0.0059
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
6122 Carbonic anhydrase 3 CA3 0.0058
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
207 Glutathione synthetase GSS 0.0057
5269 Glutathione synthetase gshB 0.0057
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0057
2251 Thymidylate kinase tmk 0.0056
2254 Thymidylate kinase DTYMK 0.0056
3522 Thymidylate kinase tmk 0.0056
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0055
3809 Estrogen-related receptor gamma ESRRG 0.0055
676 Tyrosine 3-monooxygenase TH 0.0054
817 DNA topoisomerase 2-alpha TOP2A 0.0053
4192 DNA topoisomerase 2-beta TOP2B 0.0053
818 50S ribosomal protein L10 rplJ 0.0053
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
740 Argininosuccinate synthase ASS1 0.0052
865 Argininosuccinate synthase ASS1 0.0052
2680 Argininosuccinate synthase argG 0.0052
3194 Argininosuccinate synthase argG 0.0052
4751 Mitogen-activated protein kinase 12 MAPK12 0.0052
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0052
2852 DNA mismatch repair protein mutL mutL 0.0052
2397 Dihydroxyacetone kinase dhaK 0.0052
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0052
3822 Actin, alpha skeletal muscle ACTA1 0.0051
4132 Chloride channel protein ClC-Ka CLCNKA 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0051
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
828 Phenylalanine-4-hydroxylase PAH 0.0049
3109 Phenylalanine-4-hydroxylase phhA 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
3231 Death-associated protein kinase 1 DAPK1 0.0049
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0048
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0048
1714 Mitogen-activated protein kinase 3 MAPK3 0.0048
1721 Glycogen synthase kinase-3 beta GSK3B 0.0048
1648 Elastin ELN 0.0047
936 Ephrin type-A receptor 2 EPHA2 0.0046
341 5-hydroxytryptamine 3 receptor HTR3A 0.0046
887 DNA gyrase subunit B gyrB 0.0046
4150 DNA gyrase subunit B gyrB 0.0046
6225 DNA gyrase subunit B gyrB 0.0046
1039 Histone deacetylase 9 HDAC9 0.0045
517 Alcohol dehydrogenase 1C ADH1C 0.0045
1656 CYP2B protein CYP2B 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0044
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0043
958 Insulin-like growth factor 1 receptor IGF1R 0.0043
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
469 Annexin A1 ANXA1 0.0042
6102 Arylamine N-acetyltransferase 2 NAT2 0.0041
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.004
365 Dihydrofolate reductase DHFR 0.004
2381 Dihydrofolate reductase DFR1 0.004
2833 Dihydrofolate reductase Not Available 0.004
2931 Dihydrofolate reductase folA 0.004
3544 Dihydrofolate reductase folA 0.004
3682 Dihydrofolate reductase folA 0.004
6642 Dihydrofolate reductase folA 0.004
6756 Dihydrofolate reductase dfrA 0.004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0039
459 Retinoic acid receptor RXR-alpha RXRA 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
5482 Sialidase-2 NEU2 0.0039
291 Nitric-oxide synthase, endothelial NOS3 0.0039
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0038
952 Dipeptidyl peptidase 4 DPP4 0.0038
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0036
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0036
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
997 Protein kinase C beta type PRKCB 0.0035
1517 Beta-3 adrenergic receptor ADRB3 0.0034
1836 Mitogen-activated protein kinase 10 MAPK10 0.0034
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0034
822 Aldose reductase AKR1B1 0.0034
4226 Uridine phosphorylase 2 UPP2 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
511 5-hydroxytryptamine 1F receptor HTR1F 0.0033
1291 cAMP response element-binding protein CREB1 0.0032
759 Free fatty acid receptor 1 FFAR1 0.0032
5924 Microtubule-associated protein 4 MAP4 0.0032
5923 Microtubule-associated protein tau MAPT 0.0032
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
4210 Toll-like receptor 4 TLR4 0.0032
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0032
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0032
5287 Signaling protein Not Available 0.003
5288 Shikimate kinase aroK 0.003
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.003
5304 UPF0166 protein TM_0021 TM_0021 0.003
3199 Phosphopantetheine adenylyltransferase coaD 0.003
3543 Phosphopantetheine adenylyltransferase coaD 0.003
3567 Phosphopantetheine adenylyltransferase coaD 0.003
5289 Phosphopantetheine adenylyltransferase coaD 0.003
4346 Polynucleotide kinase pseT 0.003
5293 Shikimate kinase 2 aroL 0.003
5283 D-alanine--D-alanine ligase B ddlB 0.003
5281 Plasmid segregation protein parM parM 0.003
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.003
5292 Putative partitioning protein TT_C1605 0.003
5276 Chromosomal replication initiator protein dnaA dnaA 0.003
5266 Activator of hgdC 0.003
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.003
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.003
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.003
2874 Nitrogenase iron protein 1 nifH1 0.003
5299 D-alanine--D-alanine ligase ddl 0.003
6598 D-alanine--D-alanine ligase ddl 0.003
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.003
1549 Heat shock 70 kDa protein 1 HSPA1A 0.003
5308 Preprotein translocase secA 1 subunit secA1 0.003
5259 Transcriptional regulator ntrC1 0.003
6699 Transcriptional regulator Cgl2612 0.003
5284 Large T antigen Not Available 0.003
5291 Glycogen synthase 1 glgA1 0.003
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.003
5264 DNA replication protein REP 0.003
5277 Preprotein translocase subunit secA secA 0.003
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.003
5285 Kinesin heavy chain KIF5B 0.003
5315 Chaperone protein htpG htpG 0.003
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.003
5261 Phosphoribosylformylglycinamidine synthase purL 0.003
4225 Uridine phosphorylase 1 UPP1 0.003
1852 Microtubule-associated protein 2 MAP2 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
5682 Ribonuclease pancreatic RNASE1 0.0029
654 Flavin reductase BLVRB 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
284 DNA-directed RNA polymerase beta chain rpoB 0.0029
5773 DNA-directed RNA polymerase beta chain rpoB 0.0029
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0029
702 UMP-CMP kinase CMPK1 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1053 BC269730_2 FADS1 0.0028
1395 Sodium/calcium exchanger 1 SLC8A1 0.0028
751 Potassium channel subfamily K member 6 KCNK6 0.0028
5126 Arginase rocF 0.0027
1025 Aquaporin-1 AQP1 0.0027
823 Fibroblast growth factor receptor 2 FGFR2 0.0027
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0026
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
1192 Sulfotransferase 1A1 SULT1A1 0.0026
172 Potassium channel subfamily K member 1 KCNK1 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
3601 Dihydropteroate synthase 1 folP1 0.0025
3807 Dihydropteroate synthase 1 folP1 0.0025
3808 Dihydropteroate synthase 2 folP2 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
1275 Estrogen sulfotransferase SULT1E1 0.0025
3470 Hypothetical protein MG245 homolog MPN_348 0.0025
6277 Heat shock cognate 71 kDa protein HSPA8 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
3426 Glutamine synthetase glnA 0.0025
3987 Glutamine synthetase GLUL 0.0025
3175 Glutamate--cysteine ligase gshA 0.0025
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0025
5189 Trimethylamine dehydrogenase tmd 0.0025
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0025
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0025
4106 Guanylate kinase GUK1 0.0025
4516 Guanylate kinase gmk 0.0025
2270 Dephospho-CoA kinase coaE 0.0024
4837 Cag-alfa cag-alfa 0.0024
4774 NTPase P4 Not Available 0.0024
4838 PMS1 protein homolog 2 PMS2 0.0024
2284 Adenylate kinase adk 0.0024
2296 Adenylate kinase adk 0.0024
2311 Adenylate kinase adk 0.0024
2312 Adenylate kinase Not Available 0.0024
4839 DNA polymerase III subunit tau dnaX 0.0024
908 Glutathione S-transferase theta-1 GSTT1 0.0024
1630 Integrin beta-2 ITGB2 0.0024
725 5-hydroxytryptamine 1D receptor HTR1D 0.0024
1050 Bile salt sulfotransferase SULT2A1 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
976 Platelet glycoprotein IX GP9 0.0023
2683 Mono-ADP-ribosyltransferase C3 C3 0.0023
340 Apoptotic protease-activating factor 1 APAF1 0.0023
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0023
5300 Antigen peptide transporter 1 TAP1 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
2782 Complement C1s subcomponent C1S 0.0022
5271 Focal adhesion kinase 1 PTK2 0.0022
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0022
2390 Nonsecretory ribonuclease RNASE2 0.0022
2922 Glycerol kinase glpK 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0021
320 5-hydroxytryptamine 1A receptor HTR1A 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
2282 Protein recA recA 0.0021
2315 Protein recA recA 0.0021
2332 Protein recA recA 0.0021
5263 Protein recA recA 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0021
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
3814 Complement C1r subcomponent C1R 0.0021
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.002
3669 Ribokinase rbsK 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.002
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.002
788 Creatine kinase M-type CKM 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.002
6044 Serum paraoxonase/lactonase 3 PON3 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2334 Dethiobiotin synthetase bioD 0.0019
6555 Dethiobiotin synthetase bioD 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
3957 Adenosine deaminase ADA 0.0019
2697 Uridine-cytidine kinase 2 UCK2 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
847 Mu-type opioid receptor OPRM1 0.0018
572 Integrin alpha-L ITGAL 0.0018
48 Pyridoxal kinase PDXK 0.0018
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0018
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0018
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0018
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
6395 Myosin-14 MYH14 0.0017
2091 Endoplasmin HSP90B1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
1422 Serine/threonine-protein kinase 6 AURKA 0.0016
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
3379 Kinesin-like protein KIF11 KIF11 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0016
504 Mast/stem cell growth factor receptor KIT 0.0016
5934 Cytochrome P450 26A1 CYP26A1 0.0015
1010 Cytochrome P450 51A1 CYP51A1 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
260 Cytochrome P450 51 ERG11 0.0012
761 Cytochrome P450 51 ERG11 0.0012
3163 Cytochrome P450 51 cyp51 0.0012
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
465 Calmodulin CALM1 0.0011
70 Type-1 angiotensin II receptor AGTR1 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
7 Nitric oxide synthase, inducible NOS2 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0009
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
824 Sodium-dependent serotonin transporter SLC6A4 0.0005
4943 Cytochrome c6 petJ 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4984 Neuroglobin NGB 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4961 Hemophore HasA hasA 0.0005
4910 Cytoglobin CYGB 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4916 Cyanoglobin glbN 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
5000 HemO hemO 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4909 CooA protein cooA 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4972 P450cin cinA 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4952 Catalase/peroxidase katA 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
4920 Peroxidase/catalase katG 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
4923 Cytochrome c3 DvMF_2499 0.0004
4945 Cytochrome c3 Not Available 0.0004
4949 Cytochrome c3 DVU_3171 0.0004
4968 Cytochrome c3 cytc3 0.0004
4997 Cytochrome c3 SO_2727 0.0004
5219 Cytochrome c3 cyd 0.0004
4948 Cytochrome c-553 Not Available 0.0004
2119 Cytochrome b5 CYB5A 0.0004
3189 High-molecular-weight cytochrome c hmcA 0.0004
4902 Nine-heme cytochrome c Ddes_2038 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4990 PpcA ppcA 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
518 Peroxidase/catalase T katG 0.0003
3127 Nitrite reductase nirS 0.0003
3284 Nitrite reductase nirS 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
605 Fumarate reductase flavoprotein subunit frdA 0.0003
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0003
3673 Fumarate reductase flavoprotein subunit fccA 0.0003
4912 Fumarate reductase flavoprotein subunit ifcA 0.0003
6549 Fumarate reductase flavoprotein subunit frdA 0.0003
3221 Cytochrome c4 cc4 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0003
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2298 Cytochrome P450-cam camC 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
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