DT-Web: DB00328

Identification

Name

Indomethacin

Accession Number

DB00328 (APRD00109)

Type

small molecule

Description

Indomethacin is a non-steroidal antiinflammatory agent (NSAIA) with antiinflammatory, analgesic and antipyretic activity. Its pharmacological effect is thought to be mediated through inhibition of the enzyme cyclooxygenase (COX), the enzyme responsible for catalyzes the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

357.788

Groups

approved

Monoisotopic Weight

357.076785712

Pharmacology

Indication

For moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis, osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis.

Mechanism of action

Indomethacin is a prostaglandin G/H synthase (also known as cyclooxygenase or COX) inhibitor that acts on both prostaglandin G/H synthase 1 and 2 (COX-1 and -2). Prostaglandin G/H synthase catalyzes the conversion of arachidonic acid to a number of prostaglandins involved in fever, pain, swelling, inflammation, and platelet aggregation. Indomethacin antagonizes COX by binding to the upper portion of the active site, preventing its substrate, arachidonic acid, from entering the active site. Indomethacin, unlike other NSAIDs, also inhibits phospholipase A2, the enzyme responsible for releasing arachidonic acid from phospholipids. Indomethacin is more selective for COX-1 than COX-2, which accounts for its increased adverse gastric effects relative to other NSAIDs. COX-1 is required for maintaining the protective gastric mucosal layer. The analgesic, antipyretic and anti-inflammatory effects of indomethacin occur as a result of decreased prostaglandin synthesis. Its antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

Absorption

Bioavailability is approximately 100% following oral administration and 80-90% following rectal administration.

Protein binding

97%

Biotransformation

Hepatic.

Route of elimination

Indomethacin is eliminated via renal excretion, metabolism, and biliary excretion.

Toxicity

The following symptoms may be observed following overdosage: nausea, vomiting, intense headache, dizziness, mental confusion, disorientation, or lethargy. There have been reports of paresthesias, numbness, and convulsions. The oral LD₅₀ of indomethacin in mice and rats (based on 14 day mortality response) was 50 and 12 mg/kg, respectively.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acebutolol	Risk of inhibition of renal prostaglandins
Acenocoumarol	The NSAID, indomethacin, may increase the anticoagulant effect of acenocoumarol.
Alendronate	Increased risk of gastric toxicity
Anisindione	The NSAID, indomethacin, may increase the anticoagulant effect of anisindione.
Atenolol	Risk of inhibition of renal prostaglandins
Azilsartan medoxomil	Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Betaxolol	Nonsteroidal Anti-Inflammatory Agents such as indomethacin may diminish the antihypertensive effect of Beta-Blockers such as betaxolol. Monitor for increases in blood pressure if a nonsteroidal anti-inflammatory agent (NSAID) is initiated/dose increased, or decreases in blood pressure if a NSAID is discontinued/dose decreased; this is particularly important if NSAID treatment is for extended periods of time. Ophthalmic beta-blockers are likely of little concern.
Bevantolol	Risk of inhibition of renal prostaglandins
Bisoprolol	Risk of inhibition of renal prostaglandins
Bumetanide	The NSAID, indomethacin, may decrease the diuretic and antihypertensive effects of the loop diuretic, bumetanide.
Carteolol	Risk of inhibition of renal prostaglandins
Carvedilol	Risk of inhibition of renal prostaglandins
Colesevelam	Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine	Monitor for nephrotoxicity
Dicumarol	The NSAID, indomethacin, may increase the anticoagulant effect of dicumarol.
Diflunisal	Concomitant therapy with the two NSAIDs, indomethacin and diflunisal, increases the risk of NSAID-related adverse effects (e.g. GI ulcers, bleeds, increased blood pressure).
Eltrombopag	Increases levels of Indomethacin via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Esmolol	Risk of inhibition of renal prostaglandins
Ethacrynic acid	The NSAID, indomethacin, may decrease the diuretic and antihypertensive effects of the loop diuretic, ethacrynic acid.
Furosemide	The NSAID, indomethacin, may decrease the diuretic and antihypertensive effects of the loop diuretic, furosemide.
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Labetalol	Risk of inhibition of renal prostaglandins
Lithium	The NSAID, indomethacin, may decrease the renal excretion of lithium. Increased risk of lithium toxicity.
Losartan	Indomethacin decreases the effect of losartan
Methotrexate	The NSAID, indomethacin, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Metoprolol	Risk of inhibition of renal prostaglandins
Nadolol	Risk of inhibition of renal prostaglandins
Oxprenolol	Risk of inhibition of renal prostaglandins
Penbutolol	Risk of inhibition of renal prostaglandins
Pindolol	Risk of inhibition of renal prostaglandins
Practolol	Risk of inhibition of renal prostaglandins
Pralatrexate	NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Probenecid	Probenecid increases the effect/toxicity of indomethacin
Propranolol	Risk of inhibition of renal prostaglandins
Sotalol	Risk of inhibition of renal prostaglandins
Tamoxifen	Indomethacin may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Indomethacin is initiated, discontinued or dose changed.
Telmisartan	Concomitant use of Telmisartan and Indomethacin may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol	Risk of inhibition of renal prostaglandins
Tolbutamide	Indomethacin, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Indomethacin is initiated, discontinued or dose changed.
Torasemide	The NSAID, indomethacin, may decrease the diuretic and antihypertensive effects of the loop diuretic, torasemide.
Trandolapril	The NSAID, Indomethacin, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Indomethacin is initiated, discontinued or dose changed.
Treprostinil	The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Indomethacin. Monitor for increased bleeding during concomitant thearpy.
Triamterene	Risk of acute renal impairment with this combination
Trimethoprim	The strong CYP2C9 inhibitor, Indomethacine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Indomethacine is initiated, discontinued or dose changed.
Voriconazole	Indomethacin, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole if indomethacin is initiated, discontinued or dose changed.
Warfarin	Indomethacin, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. The antiplatelet effect of indomethacin may also increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if indomethacin is initiated, discontinued or dose changed.

Food Interactions

Avoid alcohol.
Take with food or antacids to reduce irritation.

Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Pharmacological action	unknown
Actions	inhibitor
References	Bobadilla L RA, Perez-Alvarez V, Bracho Valdes I, Lopez-Sanchez P: Effect of pregnancy on the roles of nitric oxide and prostaglandins in 5-hydroxytryptamine-induced contractions in rat isolated thoracic and abdominal aorta. Clin Exp Pharmacol Physiol. 2005 Mar;32(3):202-9. - Pubmed Fornai M, Blandizzi C, Colucci R, Antonioli L, Bernardini N, Segnani C, Baragatti B, Barogi S, Berti P, Spisni R, Del Tacca M: Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice. Gut. 2005 May;54(5):608-16. - Pubmed Higuchi K, Tominaga K, Watanabe T, Uno H, Shiba M, Sasaki E, Tanigawa T, Takashima T, Hamaguchi M, Oshitani N, Matsumoto T, Iwanaga Y, Fukuda T, Fujiwara Y, Arakawa T: Indomethacin, but not Helicobacter pylori, inhibits adaptive relaxation in isolated guinea-pig stomach. Drugs Exp Clin Res. 2004;30(5-6):235-41. - Pubmed Kundu N, Walser TC, Ma X, Fulton AM: Cyclooxygenase inhibitors modulate NK activities that control metastatic disease. Cancer Immunol Immunother. 2005 Oct;54(10):981-7. Epub 2005 May 13. - Pubmed Moth CW, Prusakiewicz JJ, Marnett LJ, Lybrand TP: Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1. J Med Chem. 2005 May 19;48(10):3613-20. - Pubmed
DTHybrid score	0.8634
Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	yes
Actions	inhibitor
References	Armstrong PJ, Franklin DP, Carey DJ, Elmore JR: Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors. Ann Vasc Surg. 2005 Mar;19(2):248-57. - Pubmed Jerde TJ, Calamon-Dixon JL, Bjorling DE, Nakada SY: Celecoxib inhibits ureteral contractility and prostanoid release. Urology. 2005 Jan;65(1):185-90. - Pubmed Pilane CM, Labelle EF: Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids. J Cell Physiol. 2005 Aug;204(2):423-7. - Pubmed Yokota A, Taniguchi M, Takahira Y, Tanaka A, Takeuchi K: Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats. J Pharmacol Exp Ther. 2005 Jul;314(1):302-9. Epub 2005 Apr 14. - Pubmed Zhang GS, Fu YB, Xia M: [Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression.] Zhonghua Xue Ye Xue Za Zhi. 2004 Dec;25(12):732-5. - Pubmed
DTHybrid score	0.7928
Phospholipase A2, membrane associated
Name	Phospholipase A2, membrane associated
Gene Name	PLA2G2A
Pharmacological action	yes
Actions	inhibitor
References	Geisslinger, G., & Lötsch, J. (2004). Non-steroidal anti-inflammatory drugs. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 667-671). Berlin, Germany: Springer. -
DTHybrid score	1.1697
Prostaglandin reductase 2
Name	Prostaglandin reductase 2
Gene Name	PTGR2
Pharmacological action	unknown
Actions	inhibitor
References	Wu YH, Ko TP, Guo RT, Hu SM, Chuang LM, Wang AH: Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. Structure. 2008 Nov 12;16(11):1714-23. - Pubmed
DTHybrid score	0.5287
Peroxisome proliferator-activated receptor gamma
Name	Peroxisome proliferator-activated receptor gamma
Gene Name	PPARG
Pharmacological action	unknown
Actions	activator
References	Cho MC, Lee HS, Kim JH, Choe YK, Hong JT, Paik SG, Yoon DY: A simple ELISA for screening ligands of peroxisome proliferator-activated receptor-gamma. J Biochem Mol Biol. 2003 Mar 31;36(2):207-13. - Pubmed
DTHybrid score	1.0492
Lactoylglutathione lyase
Name	Lactoylglutathione lyase
Gene Name	GLO1
Pharmacological action	unknown
Actions	inhibitor
References	Sato S, Kwon Y, Kamisuki S, Srivastava N, Mao Q, Kawazoe Y, Uesugi M: Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. J Am Chem Soc. 2007 Jan 31;129(4):873-80. - Pubmed
DTHybrid score	0.9457
Putative G-protein coupled receptor 44
Name	Putative G-protein coupled receptor 44
Gene Name	GPR44
Pharmacological action	unknown
Actions	other/unknown
References	Hata AN, Lybrand TP, Breyer RM: Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2. J Biol Chem. 2005 Sep 16;280(37):32442-51. Epub 2005 Jul 19. - Pubmed Hata AN, Lybrand TP, Marnett LJ, Breyer RM: Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. Mol Pharmacol. 2005 Mar;67(3):640-7. Epub 2004 Nov 24. - Pubmed Mathiesen JM, Ulven T, Martini L, Gerlach LO, Heinemann A, Kostenis E: Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2. Mol Pharmacol. 2005 Aug;68(2):393-402. Epub 2005 May 3. - Pubmed
DTHybrid score	0.4299

Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5435
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.7715
Liver carboxylesterase 1
Name	Liver carboxylesterase 1
Gene Name	CES1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.6336
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate
References	Mano Y, Usui T, Kamimura H: Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur J Clin Pharmacol. 2007 Mar;63(3):289-96. Epub 2007 Jan 24. - Pubmed
DTHybrid score	0.4271
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Mano Y, Usui T, Kamimura H: In vitro inhibitory effects of non-steroidal antiinflammatory drugs on UDP-glucuronosyltransferase 1A1-catalysed estradiol 3beta-glucuronidation in human liver microsomes. Biopharm Drug Dispos. 2005 Jan;26(1):35-9. - Pubmed
DTHybrid score	0.3874
UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate,inhibitor
References	Mano Y, Usui T, Kamimura H: Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur J Clin Pharmacol. 2007 Mar;63(3):289-96. Epub 2007 Jan 24. - Pubmed Mano Y, Usui T, Kamimura H: Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes. Eur J Clin Pharmacol. 2007 Feb;63(2):211-6. Epub 2007 Jan 3. - Pubmed
DTHybrid score	0.392

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inhibitor
References	Zelcer N, Saeki T, Reid G, Beijnen JH, Borst P: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7. - Pubmed Gedeon C, Behravan J, Koren G, Piquette-Miller M: Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. Epub 2006 Feb 3. - Pubmed
DTHybrid score	0.3312
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	inhibitor
References	Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed Bai J, Lai L, Yeo HC, Goh BC, Tan TM: Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. Int J Biochem Cell Biol. 2004 Feb;36(2):247-57. - Pubmed Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y: Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxyl ate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). Drug Metab Dispos. 2009 Feb;37(2):315-21. Epub 2008 Nov 24. - Pubmed
DTHybrid score	0.4619
Multidrug resistance-associated protein 6
Name	Multidrug resistance-associated protein 6
Gene Name	ABCC6
Actions	inhibitor
References	Ilias A, Urban Z, Seidl TL, Le Saux O, Sinko E, Boyd CD, Sarkadi B, Varadi A: Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem. 2002 May 10;277(19):16860-7. Epub 2002 Mar 5. - Pubmed
DTHybrid score	0.2392
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score	0.7356
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. - Pubmed Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS: Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem Biophys Res Commun. 2003 Oct 10;310(1):222-7. - Pubmed Ilias A, Urban Z, Seidl TL, Le Saux O, Sinko E, Boyd CD, Sarkadi B, Varadi A: Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem. 2002 May 10;277(19):16860-7. Epub 2002 Mar 5. - Pubmed Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed Gedeon C, Behravan J, Koren G, Piquette-Miller M: Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. Epub 2006 Feb 3. - Pubmed
DTHybrid score	0.4471
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	substrate,inhibitor
References	Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed Kouzuki H, Suzuki H, Sugiyama Y: Pharmacokinetic study of the hepatobiliary transport of indomethacin. Pharm Res. 2000 Apr;17(4):432-8. - Pubmed
DTHybrid score	0.4704
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. - Pubmed Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol. 1999 Jan;276(1 Pt 2):F122-8. - Pubmed Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol. 1999 Feb;276(2 Pt 2):F295-303. - Pubmed Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. - Pubmed Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed Uwai Y, Saito H, Inui K: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur J Pharmacol. 2000 Dec 1;409(1):31-6. - Pubmed Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score	0.764
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40. - Pubmed Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score	0.6065
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate,inhibitor
References	Gedeon C, Behravan J, Koren G, Piquette-Miller M: Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. Epub 2006 Feb 3. - Pubmed Dahan A, Amidon GL: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7. Epub 2009 Jun 18. - Pubmed Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. Epub 2009 Mar 25. - Pubmed Kouzuki H, Suzuki H, Sugiyama Y: Pharmacokinetic study of the hepatobiliary transport of indomethacin. Pharm Res. 2000 Apr;17(4):432-8. - Pubmed
DTHybrid score	0.5196
ATP-binding cassette transporter sub-family C member 11
Name	ATP-binding cassette transporter sub-family C member 11
Gene Name	ABCC11
Actions	inhibitor
References	Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD: Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol. 2005 Feb;67(2):545-57. Epub 2004 Nov 10. - Pubmed
DTHybrid score	0.229
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	inhibitor
References	Babu E, Takeda M, Narikawa S, Kobayashi Y, Enomoto A, Tojo A, Cha SH, Sekine T, Sakthisekaran D, Endou H: Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. - Pubmed
DTHybrid score	0.4451
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions	substrate
References	Kouzuki H, Suzuki H, Sugiyama Y: Pharmacokinetic study of the hepatobiliary transport of indomethacin. Pharm Res. 2000 Apr;17(4):432-8. - Pubmed
DTHybrid score	0.301
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	substrate
References	Morita N, Kusuhara H, Sekine T, Endou H, Sugiyama Y: Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1179-84. - Pubmed
DTHybrid score	0.4112

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions
References	Not Available
DTHybrid score	0.3312
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions
References	Not Available
DTHybrid score	0.4619
Multidrug resistance-associated protein 6
Name	Multidrug resistance-associated protein 6
Gene Name	ABCC6
Actions
References	Not Available
DTHybrid score	0.2392
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.7356
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.4471
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.4704
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.764
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions
References	Not Available
DTHybrid score	0.6065
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.5196
ATP-binding cassette transporter sub-family C member 11
Name	ATP-binding cassette transporter sub-family C member 11
Gene Name	ABCC11
Actions
References	Not Available
DTHybrid score	0.229
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions
References	Not Available
DTHybrid score	0.4451
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions
References	Not Available
DTHybrid score	0.301
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions
References	Not Available
DTHybrid score	0.4112

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.7122
4924	Cytochrome P450 2C8	CYP2C8	0.4557
4200	Cytochrome P450 1A2	CYP1A2	0.3557
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.3381
6297	Prostaglandin reductase 1	PTGR1	0.3214
4118	Cytochrome P450 3A5	CYP3A5	0.3032
4119	Cytochrome P450 2D6	CYP2D6	0.3029
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.3012
6030	Cytochrome P450 2B6	CYP2B6	0.2175
776	Bile salt export pump	ABCB11	0.2132
6107	Cytochrome P450 3A7	CYP3A7	0.2047
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.192
6013	Cytochrome P450 2E1	CYP2E1	0.1874
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.1833
6024	Cytochrome P450 1A1	CYP1A1	0.1612
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.1563
6136	Multidrug resistance-associated protein 5	ABCC5	0.1491
118	Organic cation/carnitine transporter 2	SLC22A5	0.1375
6145	Solute carrier family 22 member 1	SLC22A1	0.133
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.1323
4031	Glutathione S-transferase A1	GSTA1	0.1293
5718	Cytochrome P450 2A6	CYP2A6	0.1278
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.1258
6144	Solute carrier family 22 member 2	SLC22A2	0.1258
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.1229
738	Monocarboxylate transporter 1	SLC16A1	0.1142
6148	Multidrug resistance-associated protein 7	ABCC10	0.1095
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1026
275	Arachidonate 5-lipoxygenase	ALOX5	0.1008
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0983
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0932
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0932
817	DNA topoisomerase 2-alpha	TOP2A	0.0928
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0895
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0839
6106	Cytochrome P450 2C18	CYP2C18	0.0817
1898	Cytochrome P450 1B1	CYP1B1	0.0813
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0803
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.08
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0796
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0757
6149	Solute carrier family 22 member 10	SLC22A10	0.0739
904	Glutathione S-transferase P	GSTP1	0.0719
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.068
136	Estrogen receptor	ESR1	0.0678
1757	Myeloperoxidase	MPO	0.0657
6500	Phospholipase A2	PLA2G1B	0.0644
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0641
6147	Solute carrier family 22 member 3	SLC22A3	0.0632
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0615
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0613
24	Thymidylate synthase	TMP1	0.0611
359	Thymidylate synthase	TYMS	0.0611
2626	Thymidylate synthase	thyA	0.0611
2729	Thymidylate synthase	thyA	0.0611
5352	Thymidylate synthase	THYA	0.0611
3810	Catechol O-methyltransferase	COMT	0.058
6085	Fatty acid-binding protein, intestinal	FABP2	0.058
1650	Heme carrier protein 1	SLC46A1	0.0574
6167	Organic solute transporter subunit beta	OSTB	0.0565
6166	Organic solute transporter subunit alpha	OSTA	0.0564
3947	Xanthine dehydrogenase/oxidase	XDH	0.0556
3811	Cytochrome P450 19A1	CYP19A1	0.0547
373	Transthyretin	TTR	0.0547
833	Organic cation/carnitine transporter 1	SLC22A4	0.0543
293	Gamma-glutamyl hydrolase	GGH	0.0526
2421	Signal peptidase I	lepB	0.0522
3759	Glutathione S-transferase	gst	0.0519
4541	Glutathione S-transferase	GST	0.0519
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0513
33	Cystine/glutamate transporter	SLC7A11	0.0508
723	Cytosolic phospholipase A2	PLA2G4A	0.0501
1714	Mitogen-activated protein kinase 3	MAPK3	0.0498
146	Androgen receptor	AR	0.0498
6228	Nuclear receptor coactivator 1	NCOA1	0.0496
459	Retinoic acid receptor RXR-alpha	RXRA	0.0494
901	Glutathione S-transferase Mu 4	GSTM4	0.0492
70	Type-1 angiotensin II receptor	AGTR1	0.0488
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0484
708	Alpha-tocopherol transfer protein	TTPA	0.0483
3587	Gastrotropin	FABP6	0.0472
22	30S ribosomal protein S4	rpsD	0.0462
6714	30S ribosomal protein S4	rpsD	0.0462
132	ATP-binding cassette sub-family A member 1	ABCA1	0.046
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.046
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0459
3685	Catabolite gene activator	crp	0.0452
4655	Adenylate cyclase	cyaC	0.0452
4759	Adenylate cyclase	cyaB2	0.0452
3923	Cholinesterase	BCHE	0.0446
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0445
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0441
696	Kappa-type opioid receptor	OPRK1	0.044
140	30S ribosomal protein S9	rpsI	0.0435
6719	30S ribosomal protein S9	rpsI	0.0435
6725	30S ribosomal protein S9	rpsI	0.0435
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0434
467	Delta-type opioid receptor	OPRD1	0.0432
847	Mu-type opioid receptor	OPRM1	0.043
731	HIV-1 protease	HIV-1 protease	0.0424
558	Solute carrier family 12 member 1	SLC12A1	0.0423
244	Angiotensin-converting enzyme	ACE	0.0416
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0415
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0411
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0401
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0397
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0397
824	Sodium-dependent serotonin transporter	SLC6A4	0.0397
891	Dihydropteroate synthase	folP	0.0394
5359	Dihydropteroate synthase	folP	0.0394
7175	Dihydropteroate synthase	sulI	0.0394
489	Monocarboxylate transporter 2	SLC16A7	0.0393
2344	Ribosomal small subunit pseudouridine synthase A	rsuA	0.0389
3706	Ribosomal small subunit pseudouridine synthase A	rsuA	0.0389
3677	Penicillin-insensitive murein endopeptidase precursor	mepA	0.0389
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0389
4760	Mll3241 protein	mll3241	0.0388
6218	Pannexin-1	PANX1	0.0387
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0383
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0383
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0377
5626	Nucleoside diphosphate kinase B	NME2	0.0376
908	Glutathione S-transferase theta-1	GSTT1	0.0375
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.0374
645	Penicillin-binding protein 1A	mrcA	0.0366
5805	Penicillin-binding protein 1A	ponA	0.0366
6185	Penicillin-binding protein 1A	mrcA	0.0366
6799	Penicillin-binding protein 1A	pbpA	0.0366
5226	Protein ninB	ninB	0.0364
871	Glucocorticoid receptor	NR3C1	0.0363
6102	Arylamine N-acetyltransferase 2	NAT2	0.0361
492	Histamine H1 receptor	HRH1	0.0359
718	Folate receptor gamma	FOLR3	0.0357
299	Folate receptor beta	FOLR2	0.0357
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0357
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0351
6606	Platelet-activating factor acetylhydrolase IB subunit gamma	PAFAH1B3	0.0348
4175	Platelet-activating factor acetylhydrolase	PLA2G7	0.0348
543	Penicillin-binding protein 1B	mrcB	0.0347
6186	Penicillin-binding protein 1B	ponB	0.0347
6822	Penicillin-binding protein 1b	pbp1b	0.0347
6844	Penicillin-binding protein 1b	pbp1b	0.0347
6020	Aldehyde oxidase	AOX1	0.0344
404	DNA gyrase subunit A	gyrA	0.0342
6224	DNA gyrase subunit A	gyrA	0.0342
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0342
633	Penicillin-binding proteins 1A/1B	pbpA	0.0341
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.034
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0338
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0335
822	Aldose reductase	AKR1B1	0.0334
468	Cytochrome P450 4A11	CYP4A11	0.0334
6031	Cytochrome P450 3A43	CYP3A43	0.0333
6033	High affinity interleukin-8 receptor A	CXCR1	0.0322
3766	Pyridoxamine 5'-phosphate oxidase	pdxH	0.0318
1277	Alpha-1-antitrypsin	SERPINA1	0.0317
26	Vascular endothelial growth factor receptor 3	FLT4	0.0314
6241	Nuclear receptor coactivator 2	NCOA2	0.031
273	Apoptosis regulator Bcl-2	BCL2	0.031
756	Sex hormone-binding globulin	SHBG	0.0309
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0308
3639	Thymidine phosphorylase	deoA	0.0307
3936	Thymidine phosphorylase	TYMP	0.0307
5294	Nucleoside diphosphate kinase A	NME1	0.0304
32	Vascular endothelial growth factor receptor 1	FLT1	0.03
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.03
54	Prothrombin	F2	0.03
161	Tubulin beta chain	TUBB	0.0299
312	Tubulin beta chain	TUB2	0.0299
2021	Thrombomodulin	THBD	0.0297
504	Mast/stem cell growth factor receptor	KIT	0.0294
4192	DNA topoisomerase 2-beta	TOP2B	0.0293
556	Alpha-1A adrenergic receptor	ADRA1A	0.0289
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0288
2826	Glucose--fructose oxidoreductase	gfo	0.0286
338	DNA polymerase	UL30	0.0285
379	DNA polymerase	UL54	0.0285
697	DNA polymerase	ORF28	0.0285
2482	DNA polymerase	43	0.0285
4104	DNA polymerase	BALF5	0.0285
672	Prostaglandin F2-alpha receptor	PTGFR	0.0283
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0282
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0282
4549	Endonuclease III	HP_0602	0.0277
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0275
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0274
477	DNA topoisomerase 4 subunit A	parC	0.027
886	DNA topoisomerase 4 subunit A	parC	0.027
6226	DNA topoisomerase 4 subunit A	parC	0.027
5353	Glutamate decarboxylase alpha	gadA	0.027
502	5-hydroxytryptamine 2A receptor	HTR2A	0.027
6026	Alcohol dehydrogenase 6	ADH6	0.0266
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0266
663	Solute carrier family 12 member 4	SLC12A4	0.0265
53	Solute carrier family 12 member 5	SLC12A5	0.0265
831	D(2) dopamine receptor	DRD2	0.0264
594	Thyroxine-binding globulin	SERPINA7	0.0263
614	Progesterone receptor	PGR	0.0262
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0262
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0261
183	Vascular endothelial growth factor A	VEGFA	0.0261
3312	Fatty acid-binding protein, brain	FABP7	0.0261
407	Vascular endothelial growth factor receptor 2	KDR	0.026
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0256
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0255
1	Peptidoglycan synthetase ftsI	ftsI	0.0254
4155	Peptidoglycan synthetase ftsI	ftsI	0.0254
703	NADPH azoreductase	azr	0.0254
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0252
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0252
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0251
1141	Sialidase-1	NEU1	0.0249
64	Neuraminidase	NA	0.0249
641	Neuraminidase	NA	0.0249
2676	Neuraminidase	NA	0.0249
3026	Neuraminidase	NA	0.0249
3519	Neuraminidase	NA	0.0249
6007	Neuraminidase	NA	0.0249
438	Taste receptor type 1 member 2	TAS1R2	0.0248
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0248
310	Solute carrier family 12 member 2	SLC12A2	0.0247
380	Cytochrome P450 17A1	CYP17A1	0.0247
5818	Folate receptor alpha	FOLR1	0.0246
766	Beta-2 adrenergic receptor	ADRB2	0.0244
4120	NADPH--cytochrome P450 reductase	POR	0.0244
758	Thyroid hormone receptor alpha	THRA	0.0244
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0242
6220	Aryl hydrocarbon receptor	AHR	0.0241
115	Penicillin-binding protein 2	mrdA	0.024
6069	Penicillin-binding protein 2	mrdA	0.024
6118	Penicillin-binding protein 2	penA	0.024
6187	Penicillin-binding protein 2	pbpA	0.024
6686	Penicillin-binding protein 2	pbp2	0.024
6939	Penicillin-binding protein 2	mrdA	0.024
7163	Penicillin-binding protein 2	pbpA	0.024
260	Cytochrome P450 51	ERG11	0.024
761	Cytochrome P450 51	ERG11	0.024
3163	Cytochrome P450 51	cyp51	0.024
122	P2Y purinoceptor 12	P2RY12	0.024
357	Carbonic anhydrase 2	CA2	0.0237
737	Mineralocorticoid receptor	NR3C2	0.0236
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0236
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0235
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0234
3941	Amine oxidase [flavin-containing] A	MAOA	0.0233
1867	Major prion protein	PRNP	0.0232
3809	Estrogen-related receptor gamma	ESRRG	0.0228
869	Estrogen receptor beta	ESR2	0.0228
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0226
130	Prostacyclin synthase	PTGIS	0.0226
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0225
2300	Lysozyme	E	0.0223
3633	Lysozyme	R	0.0223
5597	Lysozyme	17	0.0223
1507	Cytochrome c	CYCS	0.0223
3686	Acyl-CoA thioesterase I precursor	tesA	0.0222
632	Alpha-1B adrenergic receptor	ADRA1B	0.0222
346	Thyroid hormone receptor beta-1	THRB	0.0219
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0218
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0218
124	Histamine H2 receptor	HRH2	0.0217
777	Tumor necrosis factor	TNF	0.0217
592	Carbonic anhydrase 4	CA4	0.0217
4165	P2Y purinoceptor 2	P2RY2	0.0216
482	Glycine receptor subunit alpha-1	GLRA1	0.0216
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0215
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0215
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0212
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0211
1629	Transcription factor AP-1	JUN	0.021
2320	Thymidine kinase, cytosolic	TK1	0.0207
1792	Tissue-type plasminogen activator	PLAT	0.0207
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0206
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0205
853	Farnesyl pyrophosphate synthetase	FDPS	0.0205
4217	Telomerase reverse transcriptase	TERT	0.0205
1192	Sulfotransferase 1A1	SULT1A1	0.0204
850	Vasopressin V1b receptor	AVPR1B	0.0204
5482	Sialidase-2	NEU2	0.0204
185	Vasopressin V1a receptor	AVPR1A	0.0203
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0202
887	DNA gyrase subunit B	gyrB	0.0201
4150	DNA gyrase subunit B	gyrB	0.0201
6225	DNA gyrase subunit B	gyrB	0.0201
6207	30S ribosomal protein S14	rpsN	0.02
6209	30S ribosomal protein S19	rpsS	0.02
6712	30S ribosomal protein S19	rpsS	0.02
6726	30S ribosomal protein S19	rpsS	0.02
295	Carbonic anhydrase 1	CA1	0.02
322	Vasopressin V2 receptor	AVPR2	0.0199
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0198
527	Prostacyclin receptor	PTGIR	0.0197
23	D(1A) dopamine receptor	DRD1	0.0197
2016	Dipeptidase 1	DPEP1	0.0197
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0197
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0197
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0196
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0196
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0194
1760	Aminopeptidase N	ANPEP	0.0193
6843	Aminopeptidase N	pepN	0.0193
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0193
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0193
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0193
844	Epidermal growth factor receptor	EGFR	0.0192
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0191
4122	Histone deacetylase 2	HDAC2	0.0191
6210	Tubulin delta chain	TUBD1	0.0191
6212	Tubulin gamma-1 chain	TUBG1	0.0191
6211	Tubulin epsilon chain	TUBE1	0.0191
1353	DNA topoisomerase 1	TOP1	0.019
3552	DNA topoisomerase 1	topA	0.019
3866	Serum amyloid A protein	SAA1	0.019
1200	AMBP protein	AMBP	0.019
1932	Apolipoprotein E	APOE	0.019
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0189
117	Sterol O-acyltransferase 1	SOAT1	0.0189
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0188
1405	Thiopurine S-methyltransferase	TPMT	0.0187
2391	Ferrochelatase	hemH	0.0186
6502	Ferrochelatase	DKFZp686P18130	0.0186
1591	Ferrochelatase, mitochondrial	FECH	0.0186
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0186
1159	Interleukin-6	IL6	0.0185
952	Dipeptidyl peptidase 4	DPP4	0.0185
232	Corticosteroid-binding globulin	SERPINA6	0.0185
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0184
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0183
6168	Solute carrier family 22 member 16	SLC22A16	0.0183
896	Glutathione S-transferase Mu 1	GSTM1	0.0182
365	Dihydrofolate reductase	DHFR	0.0181
2381	Dihydrofolate reductase	DFR1	0.0181
2833	Dihydrofolate reductase	Not Available	0.0181
2931	Dihydrofolate reductase	folA	0.0181
3544	Dihydrofolate reductase	folA	0.0181
3682	Dihydrofolate reductase	folA	0.0181
6642	Dihydrofolate reductase	folA	0.0181
6756	Dihydrofolate reductase	dfrA	0.0181
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0179
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0178
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0177
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0176
789	Alpha-1D adrenergic receptor	ADRA1D	0.0174
2654	Complement control protein	C3L	0.0174
6146	High affinity copper uptake protein 1	SLC31A1	0.017
811	Translocator protein	TSPO	0.017
2178	Metabotropic glutamate receptor 5	GRM5	0.0169
1389	Transforming growth factor beta-1	TGFB1	0.0169
1648	Elastin	ELN	0.0169
6138	Multidrug resistance protein 3	ABCB4	0.0168
4773	Deoxycytidine kinase	DCK	0.0167
2249	Aspartate aminotransferase	aspC	0.0167
2671	Aspartate aminotransferase	aspC	0.0167
5490	Aspartate aminotransferase	Not Available	0.0167
1198	Serum paraoxonase/arylesterase 1	PON1	0.0167
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0167
6223	Penicillin-binding protein 1C	pbpC	0.0167
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0166
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0166
430	Follicle-stimulating hormone receptor	FSHR	0.0164
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0163
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0161
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0161
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0161
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0161
2449	Tubulin alpha-3 chain	TUBA1A	0.0161
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0161
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0161
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0161
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0161
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0161
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.016
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.016
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.016
6559	Cytochrome c oxidase subunit 2	ctaC	0.016
6669	Cytochrome c oxidase subunit 2	ctaC	0.016
371	Cytochrome c oxidase subunit 1	MT-CO1	0.016
6558	Cytochrome c oxidase subunit 1	ctaD	0.016
1050	Bile salt sulfotransferase	SULT2A1	0.0159
332	Beta-lactamase	blaZ	0.0159
2478	Beta-lactamase	ampC	0.0159
2613	Beta-lactamase	ampC	0.0159
2635	Beta-lactamase	ampC	0.0159
2700	Beta-lactamase	penP	0.0159
5445	Beta-lactamase	blaB	0.0159
6019	Beta-lactamase	SHV-7	0.0159
6701	Beta-lactamase	cphA	0.0159
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0159
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0159
6014	Cytochrome P450 2A13	CYP2A13	0.0159
6501	Fatty acid-binding protein, liver	FABP1	0.0158
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0158
3233	Bile acid receptor	NR1H4	0.0156
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0155
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0155
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0155
65	Matrix metalloproteinase-9	Not Available	0.0154
193	Beta-1 adrenergic receptor	ADRB1	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
4238	50S ribosomal protein L4	rplD	0.0153
5578	50S ribosomal protein L4	rplD	0.0153
6173	50S ribosomal protein L4	rplD	0.0153
6219	50S ribosomal protein L4	rplD	0.0153
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0153
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0152
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0152
29	Tubulin beta-1 chain	TUBB1	0.0152
5455	Arylsulfatase A	ARSA	0.0151
465	Calmodulin	CALM1	0.0151
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0151
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.015
814	Ryanodine receptor 1	RYR1	0.0149
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
6163	Copper-transporting ATPase 2	ATP7B	0.0149
6165	Copper-transporting ATPase 1	ATP7A	0.0149
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0149
165	FL cytokine receptor	FLT3	0.0149
2540	Choloylglycine hydrolase	cbh	0.0147
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0147
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0147
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0146
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0145
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0145
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
1630	Integrin beta-2	ITGB2	0.0144
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0144
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0143
6126	Carbonic anhydrase 7	CA7	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0142
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0142
4237	50S ribosomal protein L22	rplV	0.0141
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.014
867	Penicillin-binding protein 3	pbpC	0.014
6119	Penicillin-binding protein 3	pbp3	0.014
7154	Penicillin-binding protein 3	pbp3	0.014
7157	Penicillin-binding protein 3	LMHCC_2184	0.014
7162	Penicillin-binding protein 3	pbpB	0.014
7172	Penicillin-binding protein 3	pbp3	0.014
6151	Monocarboxylate transporter 10	SLC16A10	0.0139
6103	Arylamine N-acetyltransferase 1	NAT1	0.0139
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0137
1654	Interleukin-1 beta	IL1B	0.0137
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0137
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0135
3426	Glutamine synthetase	glnA	0.0135
3987	Glutamine synthetase	GLUL	0.0135
319	Opioid receptor, sigma 1	OPRS1	0.0135
3932	Glutathione S-transferase A2	GSTA2	0.0134
7	Nitric oxide synthase, inducible	NOS2	0.0134
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0134
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0133
1275	Estrogen sulfotransferase	SULT1E1	0.0132
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0131
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0131
3760	Penicillin-binding protein 5 precursor	dacA	0.0131
1852	Microtubule-associated protein 2	MAP2	0.0131
3307	Acriflavine resistance protein B	acrB	0.013
3611	Cytidine deaminase	cdd	0.013
3707	Cytidine deaminase	cdd	0.013
4211	Cytidine deaminase	CDA	0.013
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.013
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.013
713	Sodium-dependent dopamine transporter	SLC6A3	0.0129
823	Fibroblast growth factor receptor 2	FGFR2	0.0128
2539	Tubulin alpha-1 chain	TUBA4A	0.0128
4226	Uridine phosphorylase 2	UPP2	0.0127
702	UMP-CMP kinase	CMPK1	0.0127
199	Monocarboxylate transporter 8	SLC16A2	0.0126
819	Penicillin-binding protein 4	dacB	0.0125
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0125
5923	Microtubule-associated protein tau	MAPT	0.0125
5924	Microtubule-associated protein 4	MAP4	0.0125
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0123
267	Plasminogen activator inhibitor 1	SERPINE1	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0121
1039	Histone deacetylase 9	HDAC9	0.0121
3939	Amine oxidase [flavin-containing] B	MAOB	0.012
5880	Thrombopoietin receptor	MPL	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0119
5787	Angiopoietin-1 receptor	TEK	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0118
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0117
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0117
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0117
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0117
6044	Serum paraoxonase/lactonase 3	PON3	0.0117
6221	Steroid hormone receptor ERR1	ESRRA	0.0116
4225	Uridine phosphorylase 1	UPP1	0.0115
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0114
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0113
318	Alpha-2A adrenergic receptor	ADRA2A	0.0113
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0113
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0112
1656	CYP2B protein	CYP2B	0.0112
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
517	Alcohol dehydrogenase 1C	ADH1C	0.0111
494	Caspase-1	CASP1	0.0111
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0111
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0111
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.011
759	Free fatty acid receptor 1	FFAR1	0.011
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.011
1439	Lactotransferrin	LTF	0.011
291	Nitric-oxide synthase, endothelial	NOS3	0.0109
413	Amidophosphoribosyltransferase	PPAT	0.0109
2515	Amidophosphoribosyltransferase	purF	0.0109
3714	Amidophosphoribosyltransferase	purF	0.0109
572	Integrin alpha-L	ITGAL	0.0108
2443	Azurin	azu	0.0108
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0107
6182	Cytochrome P450 2J2	CYP2J2	0.0107
2853	14 kDa fatty acid-binding protein	Not Available	0.0105
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0104
1618	High affinity nerve growth factor receptor	NTRK1	0.0104
284	DNA-directed RNA polymerase beta chain	rpoB	0.0104
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0104
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0104
4037	Hypothetical protein	GPX1	0.0103
4297	Hypothetical protein	SP_1951	0.0103
4521	Hypothetical protein	BC_2969	0.0103
4540	Hypothetical protein	TM_1070	0.0103
4555	Hypothetical protein	MT1739	0.0103
4569	Hypothetical protein	mshD	0.0103
4578	Hypothetical protein	PA3270	0.0103
4747	Hypothetical protein	PA3967	0.0103
5177	Hypothetical protein	TM_0096	0.0103
5194	Hypothetical protein	PA1204	0.0103
5240	Hypothetical protein	Rv2991	0.0103
5370	Hypothetical protein	TM_1158	0.0103
5710	Hypothetical protein	Tb927.5.1360	0.0103
4032	Microsomal glutathione S-transferase 1	MGST1	0.0103
4034	Glutaredoxin-1	GLRX	0.0103
907	Glutathione peroxidase 2	GPX2	0.0103
906	Glutathione peroxidase 1	GPX1	0.0103
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0103
910	Epididymal secretory glutathione peroxidase	GPX5	0.0103
1928	Leukotriene C4 synthase	LTC4S	0.0103
911	Glutathione peroxidase 3	GPX3	0.0103
4035	Glutathione S-transferase Mu 5	GSTM5	0.0103
900	Glutathione S-transferase A4	GSTA4	0.0103
4029	Microsomal glutathione S-transferase 3	MGST3	0.0103
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0103
4042	Glutathione transferase omega-2	GSTO2	0.0103
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0103
4040	Glutathione peroxidase 7	GPX7	0.0103
4036	Glutathione peroxidase 6	GPX6	0.0103
903	Glutathione S-transferase A5	GSTA5	0.0103
4038	Glutathione peroxidase 4	GPX4	0.0103
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0103
4033	S-formylglutathione hydrolase	ESD	0.0103
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0103
1178	Adenosine A2a receptor	ADORA2A	0.0103
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0103
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.01
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.01
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.01
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.01
2808	Chloramphenicol acetyltransferase 3	cat3	0.0099
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0099
4221	Vascular endothelial growth factor	VEGF	0.0099
5816	Cadherin-5	CDH5	0.0099
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0098
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0098
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0098
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0098
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0097
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0096
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0096
897	Glutathione S-transferase kappa 1	GSTK1	0.0096
1053	BC269730_2	FADS1	0.0096
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0096
1395	Sodium/calcium exchanger 1	SLC8A1	0.0096
898	Glutathione S-transferase A3	GSTA3	0.0096
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
566	Serotransferrin	TF	0.0094
16	Adenosine A1 receptor	ADORA1	0.0094
909	Maleylacetoacetate isomerase	GSTZ1	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
2077	Caspase-3	CASP3	0.0093
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0093
461	Glycine receptor subunit alpha-3	GLRA3	0.0093
818	50S ribosomal protein L10	rplJ	0.0093
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0092
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0092
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0092
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0092
638	D(3) dopamine receptor	DRD3	0.0092
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0091
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.009
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0089
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0089
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0089
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0089
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0086
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0086
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0086
2165	Glutathione S-transferase Mu 2	GSTM2	0.0086
6131	Carbonic anhydrase 14	CA14	0.0085
76	Nitric-oxide synthase, brain	NOS1	0.0084
899	Glutathione S-transferase Mu 3	GSTM3	0.0084
905	Glutathione transferase omega-1	GSTO1	0.0084
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0083
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0083
4041	Microsomal glutathione S-transferase 2	MGST2	0.0083
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0083
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0079
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
427	Substance-P receptor	TACR1	0.0079
6171	Solute carrier family 28 member 3	SLC28A3	0.0079
3957	Adenosine deaminase	ADA	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
5798	Mitogen-activated protein kinase 11	MAPK11	0.0078
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0077
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0077
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0077
551	Carnitine O-acetyltransferase	CRAT	0.0077
207	Glutathione synthetase	GSS	0.0077
5269	Glutathione synthetase	gshB	0.0077
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
634	Squalene monooxygenase	SQLE	0.0076
7196	Squalene monooxygenase	ERG1	0.0076
1517	Beta-3 adrenergic receptor	ADRB3	0.0075
362	Melatonin receptor type 1B	MTNR1B	0.0075
571	Melatonin receptor type 1A	MTNR1A	0.0075
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0074
661	ADP/ATP translocase 1	SLC25A4	0.0074
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0074
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0074
921	Glutamate receptor 2	GRIA2	0.0074
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0074
2298	Cytochrome P450-cam	camC	0.0073
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0072
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0072
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0072
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0072
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0072
469	Annexin A1	ANXA1	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
5414	Fiber protein	L5	0.0071
5418	Fiber protein	L5	0.0071
1756	E-selectin	SELE	0.0071
49	Endothelin B receptor	EDNRB	0.007
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.007
705	Glutamate receptor 1	GRIA1	0.0067
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0067
714	Glutathione reductase, mitochondrial	GSR	0.0066
36	Insulin receptor	INSR	0.0066
2236	Casein kinase II subunit alpha	CSNK2A1	0.0066
578	Endothelin-1 receptor	EDNRA	0.0066
629	Alpha-2B adrenergic receptor	ADRA2B	0.0065
3937	Fatty-acid amide hydrolase	FAAH	0.0065
936	Ephrin type-A receptor 2	EPHA2	0.0065
5416	Coat protein VP1	Not Available	0.0065
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
3808	Dihydropteroate synthase 2	folP2	0.0063
3601	Dihydropteroate synthase 1	folP1	0.0063
3807	Dihydropteroate synthase 1	folP1	0.0063
3270	Elongation factor G	fusA	0.0062
4116	Dihydropteroate synthetase	Not Available	0.0062
3629	Endo-N-acetylneuraminidase	Not Available	0.0062
4210	Toll-like receptor 4	TLR4	0.0062
6122	Carbonic anhydrase 3	CA3	0.0061
1130	Lithostathine 1 alpha	REG1A	0.0061
716	5-hydroxytryptamine 7 receptor	HTR7	0.0061
3823	Cytokine receptor common gamma chain	IL2RG	0.0061
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
1010	Cytochrome P450 51A1	CYP51A1	0.006
2324	Botulinum neurotoxin type B	botB	0.006
3547	Enterotoxin type B	entB	0.0059
992	Protein tyrosine kinase 2 beta	PTK2B	0.0059
3007	Carbonic anhydrase 12	CA12	0.0059
4205	Carbonic anhydrase 9	CA9	0.0059
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0059
1291	cAMP response element-binding protein	CREB1	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
106	Cannabinoid receptor 2	CNR2	0.0058
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
707	72 kDa type IV collagenase	MMP2	0.0057
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0057
2058	P-selectin	SELP	0.0056
68	Cannabinoid receptor 1	CNR1	0.0055
4103	Proteasome subunit beta type 2	PSMB2	0.0055
4102	Proteasome subunit beta type 5	PSMB5	0.0055
4101	Proteasome subunit beta type 1	PSMB1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
828	Phenylalanine-4-hydroxylase	PAH	0.0054
3109	Phenylalanine-4-hydroxylase	phhA	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
4252	Penicillin-binding protein 5	dacA	0.0053
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0053
724	Interleukin-2 receptor alpha chain	IL2RA	0.0053
717	Interleukin-2 receptor subunit beta	IL2RB	0.0053
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0053
159	Penicillin-binding protein 2B	penA	0.0052
6121	Penicillin-binding protein 2B	penA	0.0052
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0052
6837	Serine/threonine-protein kinase 17B	STK17B	0.0052
2570	Tetanus toxin	tetX	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
2232	Interleukin-5	IL5	0.0051
474	Acetylcholinesterase	ACHE	0.0051
1593	Mucin-2	MUC2	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2207	Rhodopsin	RHO	0.005
2599	Tyrosine-protein kinase HCK	HCK	0.005
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.005
4692	A/G-specific adenine glycosylase	mutY	0.005
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
3856	Fibroblast growth factor receptor 3	FGFR3	0.0049
751	Potassium channel subfamily K member 6	KCNK6	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0049
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0049
595	Fibrinogen alpha chain	FGA	0.0049
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0048
5934	Cytochrome P450 26A1	CYP26A1	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0046
780	Retinoic acid receptor RXR-gamma	RXRG	0.0046
976	Platelet glycoprotein IX	GP9	0.0045
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0045
172	Potassium channel subfamily K member 1	KCNK1	0.0045
1196	Complement decay-accelerating factor	CD55	0.0045
378	Alpha-2C adrenergic receptor	ADRA2C	0.0045
2723	Cholera enterotoxin subunit B	ctxB	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0043
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0043
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
84	Nuclear receptor 0B1	NR0B1	0.0042
1123	Eosinophil cationic protein	RNASE3	0.0042
88	Retinoic acid receptor RXR-beta	RXRB	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
6432	Transporter	snf	0.0042
432	D(4) dopamine receptor	DRD4	0.0042
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0042
131	Synaptic vesicular amine transporter	SLC18A2	0.0041
408	Riboflavin kinase	RFK	0.0041
3679	MTA/SAH nucleosidase	mtnN	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0039
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0039
2408	Tyrosine-protein kinase SYK	SYK	0.0039
128	Adenine phosphoribosyltransferase	APRT	0.0038
4787	Envelope glycoprotein gp160	env	0.0038
4820	Envelope glycoprotein gp160	env	0.0038
5727	Envelope glycoprotein gp160	env	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
6677	Myelin P2 protein	PMP2	0.0038
3830	Calreticulin	CALR	0.0038
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0038
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0037
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0037
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0037
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0037
768	FK506-binding protein 1A	FKBP1A	0.0037
5300	Antigen peptide transporter 1	TAP1	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
1864	RET proto-oncogene	RET	0.0037
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0036
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0036
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0036
1992	Vitamin D-binding protein	GC	0.0036
1569	G1/S-specific cyclin-D1	CCND1	0.0036
2417	Chloramphenicol acetyltransferase	cat	0.0036
3278	Chloramphenicol acetyltransferase	cat	0.0036
6034	Hydroxyindole O-methyltransferase	ASMT	0.0035
6035	Nuclear receptor ROR-beta	RORB	0.0035
997	Protein kinase C beta type	PRKCB	0.0035
6036	Eosinophil peroxidase	EPX	0.0035
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0035
2810	Dr hemagglutinin structural subunit	draA	0.0035
268	Adenosine A2b receptor	ADORA2B	0.0035
3814	Complement C1r subcomponent	C1R	0.0035
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0035
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0034
6174	50S ribosomal protein L32	rpmF	0.0034
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0033
1970	Protein kinase C alpha type	PRKCA	0.0033
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0033
239	Coagulation factor X	F10	0.0033
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
518	Peroxidase/catalase T	katG	0.0032
2499	Tubulin beta-2C chain	TUBB2C	0.0031
1525	Heparin-binding growth factor 2	FGF2	0.0031
4203	Histamine N-methyltransferase	HNMT	0.0031
94	5-hydroxytryptamine 4 receptor	HTR4	0.0031
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
765	Indoleamine 2,3-dioxygenase	IDO1	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.003
760	Fibroblast growth factor 1	FGF1	0.003
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.003
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.003
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0029
654	Flavin reductase	BLVRB	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
683	Potassium transporter	GK0582	0.0029
1374	Natriuretic peptides B	NPPB	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
1827	Gap junction alpha-1 protein	GJA1	0.0029
1908	Vascular cell adhesion protein 1	VCAM1	0.0029
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
5126	Arginase	rocF	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1025	Aquaporin-1	AQP1	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
162	Retinoic acid receptor gamma-1	RARG	0.0026
163	D(1B) dopamine receptor	DRD5	0.0026
4878	Glycoprotein hormones alpha chain	CGA	0.0026
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0026
1072	Granzyme B	GZMB	0.0026
4877	Beta-mannanase	man	0.0026
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0026
4850	Beta-2-glycoprotein 1	APOH	0.0026
4889	Ig epsilon chain C region	IGHE	0.0026
4856	CD209 antigen	CD209	0.0026
4880	Membrane cofactor protein	CD46	0.0026
4869	Major capsid protein	A430L	0.0026
4852	Reticulon-4 receptor	RTN4R	0.0026
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0026
757	Fusion glycoprotein F0	F	0.0026
4875	Fusion glycoprotein F0	F	0.0026
4721	Beta-1,4-mannanase	manA	0.0026
1354	Beta-glucuronidase	GUSB	0.0026
4189	Alpha-galactosidase A	GLA	0.0026
4845	ADAM 33	ADAM33	0.0026
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0026
3352	Structural polyprotein	Not Available	0.0026
3628	Structural polyprotein	Not Available	0.0026
4892	Structural polyprotein	Not Available	0.0026
153	Dopamine beta-hydroxylase	DBH	0.0026
85	Growth hormone receptor	GHR	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
229	Retinoic acid receptor beta	RARB	0.0025
1541	Metalloproteinase	mmp20	0.0025
730	Retinoic acid receptor alpha	RARA	0.0024
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0024
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0024
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0024
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0024
1184	Interferon beta	IFNB1	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
4785	Ig gamma-1 chain C region	IGHG1	0.0024
6231	Pepsin A	PGA3	0.0024
1176	Mitogen-activated protein kinase 1	MAPK1	0.0024
6459	Glycodelin	PAEP	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0023
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0023
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0023
793	T-cell surface antigen CD2	CD2	0.0023
4861	Interleukin-6 receptor alpha chain	IL6R	0.0023
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0023
3837	Cytokine receptor common beta chain	CSF2RB	0.0023
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
563	Thyroid peroxidase	TPO	0.0022
605	Fumarate reductase flavoprotein subunit	frdA	0.0022
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0022
3673	Fumarate reductase flavoprotein subunit	fccA	0.0022
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0022
6549	Fumarate reductase flavoprotein subunit	frdA	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0022
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0022
6858	Inactive carboxylesterase 4	CES1P1	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
4890	Hemagglutinin	HA	0.0021
6566	Hemagglutinin	Not Available	0.0021
1379	Interleukin-12 subunit beta	IL12B	0.0021
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
283	SEC14-like protein 2	SEC14L2	0.002
6755	Poliovirus receptor	PVR	0.002
4666	Fucose-binding lectin PA-IIL	lecB	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
174	Sigma 1-type opioid receptor	SIGMAR1	0.0019
2372	Bifunctional tail protein	9	0.0019
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
554	Low-density lipoprotein receptor	LDLR	0.0018
1253	Interferon gamma	IFNG	0.0018
852	Heparin cofactor 2	SERPIND1	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1859	Prostatic acid phosphatase	ACPP	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
3140	Hemagglutinin-neuraminidase	HN	0.0018
3609	Hemagglutinin-neuraminidase	HN	0.0018
3444	Cyanovirin-N	Not Available	0.0018
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0018
4311	tRNA	TRDMT1	0.0018
4325	tRNA	trmD	0.0018
4328	tRNA	trmD	0.0018
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0017
581	Cytochrome P450 2R1	CYP2R1	0.0017
164	Histamine H4 receptor	HRH4	0.0017
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
3221	Cytochrome c4	cc4	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0016
6824	Tyrosine-protein kinase Lyn	LYN	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
484	Tyrosine-protein kinase ABL2	ABL2	0.0016
2430	Chondroitinase B	cslB	0.0016
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0016
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0016
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0016
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0016
4948	Cytochrome c-553	Not Available	0.0016
4923	Cytochrome c3	DvMF_2499	0.0016
4945	Cytochrome c3	Not Available	0.0016
4949	Cytochrome c3	DVU_3171	0.0016
4968	Cytochrome c3	cytc3	0.0016
4997	Cytochrome c3	SO_2727	0.0016
5219	Cytochrome c3	cyd	0.0016
3189	High-molecular-weight cytochrome c	hmcA	0.0016
4902	Nine-heme cytochrome c	Ddes_2038	0.0016
444	Alcohol dehydrogenase 1B	ADH1B	0.0016
958	Insulin-like growth factor 1 receptor	IGF1R	0.0016
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0015
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0015
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0015
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0015
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0015
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0015
1243	Cathepsin D	CTSD	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
233	Potassium channel subfamily K member 2	KCNK2	0.0014
251	Alcohol dehydrogenase 1A	ADH1A	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0014
309	Antithrombin-III	SERPINC1	0.0014
4386	Hemoglobin-like protein HbN	glbN	0.0014
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0013
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0013
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0013
6307	Ig gamma-2 chain C region	IGHG2	0.0013
1268	Neuropeptide S receptor	NPSR1	0.0013
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0013
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0013
2581	Chondroitinase AC	cslA	0.0013
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
4943	Cytochrome c6	petJ	0.0013
4954	Soluble cytochrome b558	Not Available	0.0013
4934	Cytochrome c-551	nirM	0.0013
5218	Cytochrome c-551	nirM	0.0013
4905	Cytochrome c2	Not Available	0.0013
4939	Cytochrome c2	cycA	0.0013
4964	Cytochrome c2	cycA	0.0013
4979	Cytochrome c2	cycA	0.0013
6673	Cytochrome c2	cycA	0.0013
4984	Neuroglobin	NGB	0.0013
4947	Bacterial hemoglobin	vhb	0.0013
4994	Hemoglobin-like protein HbO	glbO	0.0013
4916	Cyanoglobin	glbN	0.0013
4942	Diheme cytochrome c napB	napB	0.0013
4925	Cytochrome c-type protein SHP	shp	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
4998	Hemoglobin-like protein yjbI	yjbI	0.0013
4915	Cytochrome c-550	psbV	0.0013
4959	Cytochrome c-550	psbV	0.0013
5216	Cytochrome c-550	psbV	0.0013
4975	Cytochrome c-556	RPA3973	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
5000	HemO	hemO	0.0013
4961	Hemophore HasA	hasA	0.0013
4981	Iron-starvation protein PigA	pigA	0.0013
4936	Cytochrome c2 iso-2	Not Available	0.0013
4910	Cytoglobin	CYGB	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
644	Heme oxygenase 2	HMOX2	0.0013
4982	Heme oxygenase 2	pbsA2	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
4909	CooA protein	cooA	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
4904	Cytochrome c family protein	GSU1996	0.0013
4907	Cytochrome c-L	moxG	0.0013
6865	Cytochrome c-L	moxG	0.0013
4935	Cytochrome c-554	cycA1	0.0013
4976	Apocytochrome f	petA	0.0013
6407	Apocytochrome f	petA	0.0013
4971	Nonaheme cytochrome c	hmcA	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
4937	Cytochrome oxidase subunit II	rcoxA	0.0013
4764	Cytochrome P450 165C4	CYP165C4	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
4989	Cytochrome c551 peroxidase	ccp	0.0013
5222	Cytochrome c551 peroxidase	ccpA	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
4931	Cytochrome P450 167A1	CYP167A1	0.0013
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
4999	Cytochrome P450 165B3	CYP165B3	0.0013
4960	Putative cytochrome P450-family protein	SCO7417	0.0013
4972	P450cin	cinA	0.0013
4903	Methyl-accepting chemotaxis protein	Tar4	0.0013
4993	Hydroxylamine oxidoreductase	hao1	0.0013
4922	Cytochrome c, putative	SO_4144	0.0013
4952	Catalase/peroxidase	katA	0.0013
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
3093	Catalase HPII	katE	0.0013
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0013
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0013
6847	Lactase-phlorizin hydrolase	LCT	0.0013
820	Glycine receptor subunit alpha-2	GLRA2	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
694	Matrix protein 2	M	0.0012
856	Vitamin D3 receptor	VDR	0.0012
6073	Potassium channel subfamily K member 9	KCNK9	0.0012
6072	Potassium channel subfamily K member 3	KCNK3	0.0012
292	Activin receptor type-1	ACVR1	0.0012
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
6859	Protein S100-A4	S100A4	0.0012
6048	Troponin C, skeletal muscle	TNNC2	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
2112	Toll-like receptor 9	TLR9	0.0011
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
4920	Peroxidase/catalase	katG	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
2119	Cytochrome b5	CYB5A	0.001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.001
4990	PpcA	ppcA	0.001
4289	Cytochrome P450	TT_P0059	0.001
6262	Cytochrome P450	staP	0.001
3570	Cytochrome P450 152A1	cypC	0.001
4992	Cytochrome c peroxidase	Not Available	0.001
4988	Sulfite oxidase, mitochondrial	SUOX	0.001
3913	Glutamic acid decarboxylase	GAD65	0.001
2915	Sensor protein fixL	fixL	0.001
4944	Sensor protein fixL	fixL	0.001
3375	Acidic cytochrome c3	Not Available	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
4385	Cytochrome c'	Not Available	0.001
4967	Cytochrome c'	cycA	0.001
5038	Cytochrome c'	Not Available	0.001
5223	Cytochrome c'	cycP	0.001
4813	Heme oxygenase	hmuO	0.001
5769	Heme oxygenase	Not Available	0.001
6021	Adenosine kinase	ADK	0.0009
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
2230	Catalase	CAT	0.0009
3249	Catalase	katA	0.0009
3625	Catalase	katA	0.0009
4539	Catalase	katA	0.0009
4941	Catalase	katB	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
2240	Cell division protein kinase 2	CDK2	0.0009
1483	Membrane copper amine oxidase	AOC3	0.0009
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0009
1262	Corticotropin-lipotropin	POMC	0.0009
3670	Soluble cytochrome b562 precursor	cybC	0.0009
3411	Cytochrome P450 121	cyp121	0.0009
2617	Nitric oxide synthase oxygenase	nos	0.0008
2701	Nitric oxide synthase oxygenase	nos	0.0008
3291	Cytochrome c-552	cycA	0.0008
4927	Cytochrome c-552	nrfA	0.0008
4938	Cytochrome c-552	cycA	0.0008
4953	Cytochrome c-552	nrfA	0.0008
5217	Cytochrome c-552	cycM	0.0008
3102	Flavohemoprotein	hmp	0.0008
4969	Flavohemoprotein	hmp	0.0008
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0008
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0008
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0008
735	Alanine aminotransferase 1	GPT	0.0008
3904	Alanine aminotransferase 2	GPT2	0.0008
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0008
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0008
4608	Putative cytochrome P450	SCO1207	0.0007
4963	Putative cytochrome P450	SCO2884	0.0007
6254	Putative cytochrome P450	SCO6998	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
358	Cystathionine beta-synthase	CBS	0.0007
693	Hemoglobin subunit beta	HBB	0.0006
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0006
2802	Endoglucanase G	celCCG	0.0006
6268	Hydroxyacid oxidase 1	HAO1	0.0006
810	Heme oxygenase 1	HMOX1	0.0006
3391	Heme oxygenase 1	pbsA1	0.0006
719	Retinoic acid receptor responder protein 1	RARRES1	0.0006
770	Retinoic acid-induced protein 3	GPRC5A	0.0006
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
569	Retinal dehydrogenase 2	ALDH1A2	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
611	Retinal dehydrogenase 1	ALDH1A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
6133	Sodium channel subunit beta-2	SCN2B	0.0005
6134	Sodium channel subunit beta-3	SCN3B	0.0005
6129	Carbonic anhydrase-related protein 11	CA11	0.0005
6132	Sodium channel subunit beta-1	SCN1B	0.0005
6135	Sodium channel subunit beta-4	SCN4B	0.0005
6127	Carbonic anhydrase-related protein	CA8	0.0005
6128	Carbonic anhydrase-related protein 10	CA10	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0004
6130	Carbonic anhydrase 13	CA13	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
5176	YtnJ	moxC	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
1881	Hexokinase-1	HK1	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00328 - Indomethacin

Targets

Enzymes

Transporters

Carriers

Predictions