DT-Web

DB00195 - Betaxolol


Identification
Name Betaxolol
Accession Number DB00195 (APRD00245)
Type small molecule
Description A cardioselective beta-1-adrenergic antagonist with no partial agonist activity. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 307.4278
Groups approved
Monoisotopic Weight 307.214743799
Pharmacology
Indication For the management of hypertension.
Mechanism of action Betaxolol selectively blocks catecholamine stimulation of beta(1)-adrenergic receptors in the heart and vascular smooth muscle. This results in a reduction of heart rate, cardiac output, systolic and diastolic blood pressure, and possibly reflex orthostatic hypotension. Betaxolol can also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles, causing bronchospasm.
Absorption Absorption of an oral dose is complete. There is a small and consistent first-pass effect resulting in an absolute bioavailability of 89% ± 5% that is unaffected by the concomitant ingestion of food or alcohol.
Protein binding 50%
Biotransformation Primarily hepatic. Approximately 15% of the dose administered is excreted as unchanged drug, the remainder being metabolites whose contribution to the clinical effect is negligible.
Route of elimination Not Available
Toxicity Oral LD50s are 350 to 400 mg betaxolol/kg in mice and 860 to 980 mg/kg in rats. Predicted symptoms of overdose include bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetohexamide The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Chlorpropamide The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Clonidine Increased hypertension when clonidine stopped
Dihydroergotamine Ischemia with risk of gangrene
Disopyramide The beta-blocker, betaxolol, may increase the toxicity of disopyramide.
Epinephrine Beta-Blockers such as betaxolol may enhance the vasopressor effect of epinephrine. Monitor for increases in pressor effects of alpha-/beta-agonists if used in patients receiving beta-blocker therapy (including ophthalmic products). Beta1-selective (i.e., "cardioselective") agents may confer a more limited risk if used in low enough doses to allow them to retain their selectivity. The amount of epinephrine used in dental procedures as part of local anesthetic administration is not likely to be of clinical concern. Infiltrating larger volumes of local anesthetics for other surgical procedures (e.g., more than 0.06mg epinephrine) may cause clinically-relevant problems. Patients with allergies that require carrying and periodically using subcutaneous epinephrine (e.g., bee sting kits) should probably avoid the use of beta blockers.
Ergotamine Ischemia with risk of gangrene
Fenoterol Beta-Blockers (Beta-1 Selective) like betaxolol may diminish the bronchodilatory effect of Beta2-Agonists like fenoterol. Therapy should be monitored.
Formoterol Beta-Blockers (Beta1 Selective) like betaxolol may diminish the bronchodilatory effect of Beta2-Agonists like formoterol. Therapy should be monitored.
Gliclazide The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Glyburide The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Ibuprofen Nonsteroidal Anti-Inflammatory Agents such as ibuprofen may diminish the antihypertensive effect of Beta-Blockers such as betaxolol. Monitor for increases in blood pressure if a nonsteroidal anti-inflammatory agent (NSAID) is initiated/dose increased, or decreases in blood pressure if a NSAID is discontinued/dose decreased; this is particularly important if NSAID treatment is for extended periods of time. Ophthalmic beta-blockers are likely of little concern.
Indomethacin Nonsteroidal Anti-Inflammatory Agents such as indomethacin may diminish the antihypertensive effect of Beta-Blockers such as betaxolol. Monitor for increases in blood pressure if a nonsteroidal anti-inflammatory agent (NSAID) is initiated/dose increased, or decreases in blood pressure if a NSAID is discontinued/dose decreased; this is particularly important if NSAID treatment is for extended periods of time. Ophthalmic beta-blockers are likely of little concern.
Insulin Glargine The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Methacholine Beta-Blockers like betaxolol may worsen brochoconstriction and decrease the effectiveness of agents used to treat the resulting bronchoconstriction. Use of betaxolol and methacholine concomitantly is contraindicated.
Methysergide Ischemia with risk of gangrene
Orciprenaline Beta-Blockers (Beta1 Selective) like betaxolol may diminish the bronchodilatory effect of Beta2-Agonists like orciprenaline. Therapy should be monitored.
Pipobroman Antagonism
Piroxicam Nonsteroidal Anti-Inflammatory Agents such as piroxicam may diminish the antihypertensive effect of Beta-Blockers such as betaxolol. Monitor for increases in blood pressure if a nonsteroidal anti-inflammatory agent (NSAID) is initiated/dose increased, or decreases in blood pressure if a NSAID is discontinued/dose decreased; this is particularly important if NSAID treatment is for extended periods of time. Ophthalmic beta-blockers are likely of little concern.
Prazosin Beta-Blockers such as betaxolol may enhance the orthostatic hypotensive effect of Alpha1-Blockers such as prazosin. The risk associated with ophthalmic products is probably less than systemic products. Exercise caution if an alpha1-blocker is added to existing beta-blocker therapy. Monitor for hypotension during first few days of concomitant therapy. A priori reduction in alpha1-blocker (especially systemic) dose may be warranted. Administering the first dose of systemic agents at bedtime may help minimize risk of severe hypotension. The risk associated with the use of ophthalmic products in either interacting group is probably less than that associated with systemic agents. If the alpha1-blocker is being used to treat BPH, consider using tamsulosin since its alpha1-A selectivity is least likely to cause hypotension.
Repaglinide The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Rituximab Antihypertensives like betaxolol may enhance the hypotensive effect of rituximab. Consider temporarily withholding antihypertensive medications for 12 hours prior to rituximab infusion to avoid excessive hypotension during or immediately after infusion.
Terazosin Increased risk of hypotension. Initiate concomitant therapy cautiously.
Terbutaline Beta-Blockers (Beta1 Selective) like betaxolol may diminish the bronchodilatory effect of Beta2-Agonists like terbutaline. Therapy should be monitored.
Thiabendazole The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Betaxolol by decreasing Betaxolol metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Betaxolol if Thiabendazole is initiated, discontinued or dose changed
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Food Interactions Not Available

Targets


Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action yes
Actions antagonist
References
  • McLean AJ, Zeng FY, Behan D, Chalmers D, Milligan G: Generation and analysis of constitutively active and physically destabilized mutants of the human beta(1)-adrenoceptor. Mol Pharmacol. 2002 Sep;62(3):747-55. - Pubmed
  • Rudoy CA, Van Bockstaele EJ: Betaxolol, a selective beta(1)-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1119-29. Epub 2007 Apr 19. - Pubmed
  • Satoh N, Suzuki J, Bessho H, Kitada Y, Narimatsu A, Tobe A: Effects of betaxolol on cardiohemodynamics and coronary circulation in anesthetized dogs: comparison with atenolol and propranolol. Jpn J Pharmacol. 1990 Oct;54(2):113-9. - Pubmed
  • Lesar TS: Comparison of ophthalmic beta-blocking agents. Clin Pharm. 1987 Jun;6(6):451-63. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7085
Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action unknown
Actions antagonist
References
  • Rait JL: Systemic effects of topical ophthalmic beta-adrenoceptor antagonists. Aust N Z J Ophthalmol. 1999 Feb;27(1):57-64. - Pubmed
DTHybrid score 0.7142

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2788
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3721

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1796
1517 Beta-3 adrenergic receptor ADRB3 0.1387
1588 Multidrug resistance protein 1 ABCB1 0.1159
6016 Cytochrome P450 2C19 CYP2C19 0.1106
4757 Cytochrome P450 2C9 CYP2C9 0.1056
556 Alpha-1A adrenergic receptor ADRA1A 0.0835
6024 Cytochrome P450 1A1 CYP1A1 0.0745
320 5-hydroxytryptamine 1A receptor HTR1A 0.069
4924 Cytochrome P450 2C8 CYP2C8 0.0622
4118 Cytochrome P450 3A5 CYP3A5 0.0611
318 Alpha-2A adrenergic receptor ADRA2A 0.0569
6013 Cytochrome P450 2E1 CYP2E1 0.0564
6030 Cytochrome P450 2B6 CYP2B6 0.0549
6107 Cytochrome P450 3A7 CYP3A7 0.0498
6144 Solute carrier family 22 member 2 SLC22A2 0.0469
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0453
5718 Cytochrome P450 2A6 CYP2A6 0.0435
885 5-hydroxytryptamine 1B receptor HTR1B 0.0431
824 Sodium-dependent serotonin transporter SLC6A4 0.0429
492 Histamine H1 receptor HRH1 0.0405
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0397
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0385
6145 Solute carrier family 22 member 1 SLC22A1 0.0377
632 Alpha-1B adrenergic receptor ADRA1B 0.0376
3923 Cholinesterase BCHE 0.0365
629 Alpha-2B adrenergic receptor ADRA2B 0.034
3941 Amine oxidase [flavin-containing] A MAOA 0.0322
502 5-hydroxytryptamine 2A receptor HTR2A 0.0316
831 D(2) dopamine receptor DRD2 0.0309
713 Sodium-dependent dopamine transporter SLC6A3 0.0298
378 Alpha-2C adrenergic receptor ADRA2C 0.0286
36 Insulin receptor INSR 0.0258
23 D(1A) dopamine receptor DRD1 0.0255
2300 Lysozyme E 0.0253
3633 Lysozyme R 0.0253
5597 Lysozyme 17 0.0253
118 Organic cation/carnitine transporter 2 SLC22A5 0.0244
20 Prostaglandin G/H synthase 1 PTGS1 0.0226
789 Alpha-1D adrenergic receptor ADRA1D 0.0226
587 Serum albumin ALB 0.0223
3810 Catechol O-methyltransferase COMT 0.0221
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0215
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0215
590 5-hydroxytryptamine 2C receptor HTR2C 0.0211
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.021
1820 Beta-nerve growth factor NGF 0.0186
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0177
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0168
777 Tumor necrosis factor TNF 0.0165
6106 Cytochrome P450 2C18 CYP2C18 0.0162
3939 Amine oxidase [flavin-containing] B MAOB 0.0161
828 Phenylalanine-4-hydroxylase PAH 0.016
3109 Phenylalanine-4-hydroxylase phhA 0.016
638 D(3) dopamine receptor DRD3 0.0155
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0153
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0151
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0151
6147 Solute carrier family 22 member 3 SLC22A3 0.0149
1898 Cytochrome P450 1B1 CYP1B1 0.0141
465 Calmodulin CALM1 0.0138
341 5-hydroxytryptamine 3 receptor HTR3A 0.0135
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0134
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0132
817 DNA topoisomerase 2-alpha TOP2A 0.0128
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0128
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
847 Mu-type opioid receptor OPRM1 0.0127
432 D(4) dopamine receptor DRD4 0.0126
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0125
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0124
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
3076 Antigen 85-C fbpC 0.0122
725 5-hydroxytryptamine 1D receptor HTR1D 0.0119
1729 Solute carrier family 22 member 6 SLC22A6 0.0119
862 Multidrug resistance-associated protein 1 ABCC1 0.0115
833 Organic cation/carnitine transporter 1 SLC22A4 0.0115
3811 Cytochrome P450 19A1 CYP19A1 0.0111
131 Synaptic vesicular amine transporter SLC18A2 0.011
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.011
290 Prostaglandin G/H synthase 2 PTGS2 0.0109
436 5-hydroxytryptamine 2B receptor HTR2B 0.0108
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0099
467 Delta-type opioid receptor OPRD1 0.0098
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
696 Kappa-type opioid receptor OPRK1 0.0096
6847 Lactase-phlorizin hydrolase LCT 0.0093
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0093
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0092
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0089
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0087
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0086
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0085
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0084
1176 Mitogen-activated protein kinase 1 MAPK1 0.0083
3947 Xanthine dehydrogenase/oxidase XDH 0.0081
6164 POU domain, class 5, transcription factor 1 POU5F1 0.008
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0078
716 5-hydroxytryptamine 7 receptor HTR7 0.0076
163 D(1B) dopamine receptor DRD5 0.0075
124 Histamine H2 receptor HRH2 0.0075
1374 Natriuretic peptides B NPPB 0.0075
1827 Gap junction alpha-1 protein GJA1 0.0075
1908 Vascular cell adhesion protein 1 VCAM1 0.0075
16 Adenosine A1 receptor ADORA1 0.0075
1256 5-hydroxytryptamine 6 receptor HTR6 0.0074
731 HIV-1 protease HIV-1 protease 0.0073
1178 Adenosine A2a receptor ADORA2A 0.0071
474 Acetylcholinesterase ACHE 0.0069
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0064
173 Toll-like receptor 7 TLR7 0.0063
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0063
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0062
565 Extracellular calcium-sensing receptor CASR 0.0062
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0062
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0062
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0061
6220 Aryl hydrocarbon receptor AHR 0.0061
776 Bile salt export pump ABCB11 0.0061
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0059
94 5-hydroxytryptamine 4 receptor HTR4 0.0059
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0058
183 Vascular endothelial growth factor A VEGFA 0.0056
6143 Solute carrier family 22 member 7 SLC22A7 0.0054
6432 Transporter snf 0.0054
136 Estrogen receptor ESR1 0.0053
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0053
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
2164 Multidrug resistance-associated protein 4 ABCC4 0.005
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.005
468 Cytochrome P450 4A11 CYP4A11 0.0049
6142 Solute carrier family 22 member 8 SLC22A8 0.0047
380 Cytochrome P450 17A1 CYP17A1 0.0046
1360 Sphingomyelin phosphodiesterase SMPD1 0.0045
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0045
6014 Cytochrome P450 2A13 CYP2A13 0.0045
6151 Monocarboxylate transporter 10 SLC16A10 0.0045
2112 Toll-like receptor 9 TLR9 0.0044
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0044
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0043
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0043
6031 Cytochrome P450 3A43 CYP3A43 0.0043
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0043
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0043
511 5-hydroxytryptamine 1F receptor HTR1F 0.0043
6182 Cytochrome P450 2J2 CYP2J2 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
4122 Histone deacetylase 2 HDAC2 0.0042
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0042
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0041
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0041
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.004
504 Mast/stem cell growth factor receptor KIT 0.004
1757 Myeloperoxidase MPO 0.004
871 Glucocorticoid receptor NR3C1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0038
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0038
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0038
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0038
1656 CYP2B protein CYP2B 0.0036
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0036
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0036
4228 Keratin, type II cytoskeletal 7 KRT7 0.0036
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0035
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
6148 Multidrug resistance-associated protein 7 ABCC10 0.0034
273 Apoptosis regulator Bcl-2 BCL2 0.0034
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0034
712 Tubulin alpha chain TUB1 0.0034
6506 Stathmin-4 STMN4 0.0033
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0033
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0032
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0032
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
228 Beta platelet-derived growth factor receptor PDGFRB 0.0031
260 Cytochrome P450 51 ERG11 0.0031
761 Cytochrome P450 51 ERG11 0.0031
3163 Cytochrome P450 51 cyp51 0.0031
26 Vascular endothelial growth factor receptor 3 FLT4 0.0031
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
844 Epidermal growth factor receptor EGFR 0.0031
818 50S ribosomal protein L10 rplJ 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
373 Transthyretin TTR 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
32 Vascular endothelial growth factor receptor 1 FLT1 0.003
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0029
365 Dihydrofolate reductase DHFR 0.0028
2381 Dihydrofolate reductase DFR1 0.0028
2833 Dihydrofolate reductase Not Available 0.0028
2931 Dihydrofolate reductase folA 0.0028
3544 Dihydrofolate reductase folA 0.0028
3682 Dihydrofolate reductase folA 0.0028
6642 Dihydrofolate reductase folA 0.0028
6756 Dihydrofolate reductase dfrA 0.0028
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0028
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0028
1010 Cytochrome P450 51A1 CYP51A1 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0028
233 Potassium channel subfamily K member 2 KCNK2 0.0028
1629 Transcription factor AP-1 JUN 0.0028
407 Vascular endothelial growth factor receptor 2 KDR 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3957 Adenosine deaminase ADA 0.0026
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0026
528 5-hydroxytryptamine 1E receptor HTR1E 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0026
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0026
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0026
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0026
122 P2Y purinoceptor 12 P2RY12 0.0026
6102 Arylamine N-acetyltransferase 2 NAT2 0.0025
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0025
5880 Thrombopoietin receptor MPL 0.0025
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0025
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0025
4604 Liver carboxylesterase 1 CES1 0.0025
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
146 Androgen receptor AR 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
6070 Nischarin NISCH 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0024
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
869 Estrogen receptor beta ESR2 0.0023
70 Type-1 angiotensin II receptor AGTR1 0.0023
4311 tRNA TRDMT1 0.0022
4325 tRNA trmD 0.0022
4328 tRNA trmD 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
518 Peroxidase/catalase T katG 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0021
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0021
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.002
563 Thyroid peroxidase TPO 0.002
158 Sodium channel protein type 1 subunit alpha SCN1A 0.002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.002
6020 Aldehyde oxidase AOX1 0.002
174 Sigma 1-type opioid receptor SIGMAR1 0.002
1050 Bile salt sulfotransferase SULT2A1 0.0019
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
2449 Tubulin alpha-3 chain TUBA1A 0.0019
4203 Histamine N-methyltransferase HNMT 0.0019
482 Glycine receptor subunit alpha-1 GLRA1 0.0019
4120 NADPH--cytochrome P450 reductase POR 0.0019
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0019
904 Glutathione S-transferase P GSTP1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
543 Penicillin-binding protein 1B mrcB 0.0018
6186 Penicillin-binding protein 1B ponB 0.0018
6822 Penicillin-binding protein 1b pbp1b 0.0018
6844 Penicillin-binding protein 1b pbp1b 0.0018
6146 High affinity copper uptake protein 1 SLC31A1 0.0018
1192 Sulfotransferase 1A1 SULT1A1 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
645 Penicillin-binding protein 1A mrcA 0.0018
5805 Penicillin-binding protein 1A ponA 0.0018
6185 Penicillin-binding protein 1A mrcA 0.0018
6799 Penicillin-binding protein 1A pbpA 0.0018
159 Penicillin-binding protein 2B penA 0.0018
6121 Penicillin-binding protein 2B penA 0.0018
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
1024 Solute carrier family 22 member 11 SLC22A11 0.0018
6136 Multidrug resistance-associated protein 5 ABCC5 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0017
1648 Elastin ELN 0.0017
6137 Multidrug resistance-associated protein 6 ABCC6 0.0017
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0016
738 Monocarboxylate transporter 1 SLC16A1 0.0016
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0016
1243 Cathepsin D CTSD 0.0016
427 Substance-P receptor TACR1 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0015
921 Glutamate receptor 2 GRIA2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0015
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0015
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1618 High affinity nerve growth factor receptor NTRK1 0.0015
537 ATP synthase delta chain, mitochondrial ATP5D 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
3086 Plasmepsin-2 Not Available 0.0014
976 Platelet glycoprotein IX GP9 0.0014
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0014
823 Fibroblast growth factor receptor 2 FGFR2 0.0014
4103 Proteasome subunit beta type 2 PSMB2 0.0014
4102 Proteasome subunit beta type 5 PSMB5 0.0014
4101 Proteasome subunit beta type 1 PSMB1 0.0014
614 Progesterone receptor PGR 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
164 Histamine H4 receptor HRH4 0.0014
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0013
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
3404 Exotoxin A eta 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
814 Ryanodine receptor 1 RYR1 0.0013
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0013
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0013
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0013
295 Carbonic anhydrase 1 CA1 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6141 Sodium/bile acid cotransporter SLC10A1 0.0012
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0012
165 FL cytokine receptor FLT3 0.0012
705 Glutamate receptor 1 GRIA1 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
4192 DNA topoisomerase 2-beta TOP2B 0.0011
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
239 Coagulation factor X F10 0.001
4237 50S ribosomal protein L22 rplV 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
1864 RET proto-oncogene RET 0.001
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.001
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.001
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.001
737 Mineralocorticoid receptor NR3C2 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
144 Hemoglobin subunit alpha HBA1 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.001
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.001
153 Dopamine beta-hydroxylase DBH 0.001
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.001
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.001
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.001
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.001
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.001
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.001
760 Fibroblast growth factor 1 FGF1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0009
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
5934 Cytochrome P450 26A1 CYP26A1 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
7 Nitric oxide synthase, inducible NOS2 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0009
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0008
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0008
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0008
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
3937 Fatty-acid amide hydrolase FAAH 0.0008
1262 Corticotropin-lipotropin POMC 0.0008
1341 Histamine H3 receptor HRH3 0.0008
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0008
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0008
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
3830 Calreticulin CALR 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
811 Translocator protein TSPO 0.0008
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0008
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
822 Aldose reductase AKR1B1 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
4773 Deoxycytidine kinase DCK 0.0007
1992 Vitamin D-binding protein GC 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0006
592 Carbonic anhydrase 4 CA4 0.0006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
1630 Integrin beta-2 ITGB2 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
798 Osteocalcin BGLAP 0.0005
856 Vitamin D3 receptor VDR 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
896 Glutathione S-transferase Mu 1 GSTM1 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
469 Annexin A1 ANXA1 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
6085 Fatty acid-binding protein, intestinal FABP2 0.0003
2981 Phospholipase A2, membrane associated PLA2G2A 0.0003
2207 Rhodopsin RHO 0.0003
54 Prothrombin F2 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
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