DT-Web

DB00730 - Thiabendazole


Identification
Name Thiabendazole
Accession Number DB00730 (APRD01252, DB08630)
Type small molecule
Description 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 201.248
Groups approved
Monoisotopic Weight 201.036067929
Pharmacology
Indication For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.
Mechanism of action The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.
Absorption Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin.
Protein binding Not Available
Biotransformation Hepatic. Metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates.
Route of elimination It is metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates.
Toxicity Overdosage may be associated with transient disturbances of vision and psychic alterations. The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively.
Affected organisms
  • Roundworms, hookworms, and other helminth species
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Acenocoumarol by decreasing Acenocoumarol metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Acenocoumarol if Thiabendazole is initiated, discontinued or dose changed.
Alosetron The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Alosetron by decreasing Alosetron metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Alosetron if Thiabendazole is initiated, discontinued or dose changed.
Aminophylline The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Aminophylline by decreasing Aminophylline metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Aminophylline if Thiabendazole is initiated, discontinued or dose changed.
Betaxolol The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Betaxolol by decreasing Betaxolol metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Betaxolol if Thiabendazole is initiated, discontinued or dose changed
Caffeine The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Caffeine by decreasing Caffeine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Caffeine if Thiabendazole is initiated, discontinued or dose changed.
Clomipramine The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Clomipramine by decreasing Clomipramine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Clomipramine if Thiabendazole is initiated, discontinued or dose changed.
Clozapine The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Clozapine by decreasing Clozapine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Clozapine if Thiabendazole is initiated, discontinued or dose changed.
Cyclobenzaprine The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Cyclobenzaprine by decreasing Cyclobenzaprine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Cyclobenzaprine if Thiabendazole is initiated, discontinued or dose changed.
Dacarbazine The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Dacarbazine by decreasing Dacarbazine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Dacarbazine if Thiabendazole is initiated, discontinued or dose changed.
Doxepin The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Doxepin by decreasing Doxepin metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Doxepin if Thiabendazole is initiated, discontinued or dose changed.
Duloxetine The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Duloxetine by decreasing Duloxetine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Duloxetine if Thiabendazole is initiated, discontinued or dose changed.
Flutamide The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Flutamide by decreasing Flutamide metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Flutamide if Thiabendazole is initiated, discontinued or dose changed.
Fluvoxamine The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Fluvoxamine by decreasing Fluvoxamine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Fluvoxamine if Thiabendazole is initiated, discontinued or dose changed.
Guanabenz The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Guanabenz by decreasing Guanabenz metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Guanabenz if Thiabendazole is initiated, discontinued or dose changed.
Oxtriphylline Thiabendazole increases the effect and toxicity of theophylline
Ramelteon Thiabendazole increases levels/toxicity of ramelteon
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Thiabendazole. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Thiabendazole is initiated, discontinued or if the dose is changed.
Theophylline The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Theophylline by decreasing Theophylline metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Theophylline if Thiabendazole is initiated, discontinued or dose changed.
Thiothixene The strong CYP1A2 inhibitor, Thiobendazole, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Thiobendazole is initiated, discontinued or dose changed.
Tizanidine The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Tizanidine by decreasing Tizanidine metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Tizanidine if Thiabendazole is initiated, discontinued or dose changed.
Trifluoperazine The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Trifluoperazine by decreasing Trifluoperazine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Trifluoperazine if Thiabendazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Fumarate reductase flavoprotein subunit
Name Fumarate reductase flavoprotein subunit
Gene Name frdA
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Ge Z, Feng Y, Dangler CA, Xu S, Taylor NS, Fox JG: Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microb Pathog. 2000 Nov;29(5):279-87. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4555

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3287
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2553

Predictions


Id Partner name Gene Name Score
2709 Fumarate reductase flavoprotein subunit SO_0970 0.4555
3673 Fumarate reductase flavoprotein subunit fccA 0.4555
4912 Fumarate reductase flavoprotein subunit ifcA 0.4555
6549 Fumarate reductase flavoprotein subunit frdA 0.4555
6464 Fumarate reductase subunit D frdD 0.2311
6463 Fumarate reductase subunit C frdC 0.2311
6462 Fumarate reductase iron-sulfur subunit frdB 0.2308
6550 Fumarate reductase iron-sulfur subunit frdB 0.2308
4512 Cytochrome P450 3A4 CYP3A4 0.1099
6632 Formate dehydrogenase, nitrate-inducible, cytochrome b556(fdn) subunit fdnI 0.1077
6634 Cytochrome c nitrite reductase, catalytic subunit NfrA, putative DVU_0625 0.1076
4119 Cytochrome P450 2D6 CYP2D6 0.0868
4757 Cytochrome P450 2C9 CYP2C9 0.0748
6016 Cytochrome P450 2C19 CYP2C19 0.0684
1588 Multidrug resistance protein 1 ABCB1 0.0614
6013 Cytochrome P450 2E1 CYP2E1 0.0598
4924 Cytochrome P450 2C8 CYP2C8 0.0508
4118 Cytochrome P450 3A5 CYP3A5 0.0501
6030 Cytochrome P450 2B6 CYP2B6 0.0463
5718 Cytochrome P450 2A6 CYP2A6 0.0403
1898 Cytochrome P450 1B1 CYP1B1 0.0332
6107 Cytochrome P450 3A7 CYP3A7 0.0318
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0283
36 Insulin receptor INSR 0.0258
20 Prostaglandin G/H synthase 1 PTGS1 0.0217
587 Serum albumin ALB 0.0193
318 Alpha-2A adrenergic receptor ADRA2A 0.0157
1729 Solute carrier family 22 member 6 SLC22A6 0.015
477 DNA topoisomerase 4 subunit A parC 0.0144
886 DNA topoisomerase 4 subunit A parC 0.0144
6226 DNA topoisomerase 4 subunit A parC 0.0144
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0143
6145 Solute carrier family 22 member 1 SLC22A1 0.0142
404 DNA gyrase subunit A gyrA 0.0141
6224 DNA gyrase subunit A gyrA 0.0141
290 Prostaglandin G/H synthase 2 PTGS2 0.0141
6106 Cytochrome P450 2C18 CYP2C18 0.0141
492 Histamine H1 receptor HRH1 0.0141
468 Cytochrome P450 4A11 CYP4A11 0.0138
3811 Cytochrome P450 19A1 CYP19A1 0.0133
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0133
193 Beta-1 adrenergic receptor ADRB1 0.013
6144 Solute carrier family 22 member 2 SLC22A2 0.0126
136 Estrogen receptor ESR1 0.0123
777 Tumor necrosis factor TNF 0.0121
831 D(2) dopamine receptor DRD2 0.012
817 DNA topoisomerase 2-alpha TOP2A 0.012
502 5-hydroxytryptamine 2A receptor HTR2A 0.0118
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0118
6014 Cytochrome P450 2A13 CYP2A13 0.0118
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0117
48 Pyridoxal kinase PDXK 0.0116
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0116
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0115
3941 Amine oxidase [flavin-containing] A MAOA 0.0113
118 Organic cation/carnitine transporter 2 SLC22A5 0.011
556 Alpha-1A adrenergic receptor ADRA1A 0.011
776 Bile salt export pump ABCB11 0.0108
862 Multidrug resistance-associated protein 1 ABCC1 0.0105
613 Atrial natriuretic peptide receptor A NPR1 0.0105
885 5-hydroxytryptamine 1B receptor HTR1B 0.0104
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0103
766 Beta-2 adrenergic receptor ADRB2 0.0102
23 D(1A) dopamine receptor DRD1 0.0101
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0101
590 5-hydroxytryptamine 2C receptor HTR2C 0.01
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.01
341 5-hydroxytryptamine 3 receptor HTR3A 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0096
824 Sodium-dependent serotonin transporter SLC6A4 0.0094
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0094
2499 Tubulin beta-2C chain TUBB2C 0.0094
1517 Beta-3 adrenergic receptor ADRB3 0.0091
16 Adenosine A1 receptor ADORA1 0.009
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0089
6147 Solute carrier family 22 member 3 SLC22A3 0.0087
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0086
2449 Tubulin alpha-3 chain TUBA1A 0.0086
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0085
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
725 5-hydroxytryptamine 1D receptor HTR1D 0.0081
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0078
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0078
629 Alpha-2B adrenergic receptor ADRA2B 0.0078
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0077
833 Organic cation/carnitine transporter 1 SLC22A4 0.0077
632 Alpha-1B adrenergic receptor ADRA1B 0.0076
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0076
1178 Adenosine A2a receptor ADORA2A 0.0076
465 Calmodulin CALM1 0.0076
320 5-hydroxytryptamine 1A receptor HTR1A 0.0076
6220 Aryl hydrocarbon receptor AHR 0.0074
6142 Solute carrier family 22 member 8 SLC22A8 0.0073
3939 Amine oxidase [flavin-containing] B MAOB 0.0072
871 Glucocorticoid receptor NR3C1 0.0072
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
1757 Myeloperoxidase MPO 0.0068
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0067
638 D(3) dopamine receptor DRD3 0.0066
571 Melatonin receptor type 1A MTNR1A 0.0066
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0066
362 Melatonin receptor type 1B MTNR1B 0.0066
378 Alpha-2C adrenergic receptor ADRA2C 0.0065
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0065
1820 Beta-nerve growth factor NGF 0.0064
4228 Keratin, type II cytoskeletal 7 KRT7 0.0063
789 Alpha-1D adrenergic receptor ADRA1D 0.0063
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0062
198 Sodium channel protein type 10 subunit alpha SCN10A 0.006
3947 Xanthine dehydrogenase/oxidase XDH 0.006
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.006
33 Cystine/glutamate transporter SLC7A11 0.0058
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
820 Glycine receptor subunit alpha-2 GLRA2 0.0056
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0055
6143 Solute carrier family 22 member 7 SLC22A7 0.0054
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0054
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0054
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0054
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0054
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0053
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0052
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0052
1714 Mitogen-activated protein kinase 3 MAPK3 0.0052
713 Sodium-dependent dopamine transporter SLC6A3 0.0052
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0051
6148 Multidrug resistance-associated protein 7 ABCC10 0.0051
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0049
1010 Cytochrome P450 51A1 CYP51A1 0.0049
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0048
3932 Glutathione S-transferase A2 GSTA2 0.0047
844 Epidermal growth factor receptor EGFR 0.0047
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0047
2164 Multidrug resistance-associated protein 4 ABCC4 0.0047
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0046
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0045
4122 Histone deacetylase 2 HDAC2 0.0045
432 D(4) dopamine receptor DRD4 0.0044
3923 Cholinesterase BCHE 0.0044
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0042
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0042
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0042
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0041
6146 High affinity copper uptake protein 1 SLC31A1 0.004
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.004
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
4311 tRNA TRDMT1 0.0039
4325 tRNA trmD 0.0039
4328 tRNA trmD 0.0039
1176 Mitogen-activated protein kinase 1 MAPK1 0.0038
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0037
122 P2Y purinoceptor 12 P2RY12 0.0037
373 Transthyretin TTR 0.0037
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0036
6043 Putative G-protein coupled receptor 44 GPR44 0.0036
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
2236 Casein kinase II subunit alpha CSNK2A1 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0035
273 Apoptosis regulator Bcl-2 BCL2 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
4203 Histamine N-methyltransferase HNMT 0.0034
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0034
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0033
869 Estrogen receptor beta ESR2 0.0032
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0032
3957 Adenosine deaminase ADA 0.0032
228 Beta platelet-derived growth factor receptor PDGFRB 0.0032
1192 Sulfotransferase 1A1 SULT1A1 0.0032
146 Androgen receptor AR 0.0032
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0031
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0031
1629 Transcription factor AP-1 JUN 0.0031
823 Fibroblast growth factor receptor 2 FGFR2 0.0031
818 50S ribosomal protein L10 rplJ 0.003
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.003
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.003
260 Cytochrome P450 51 ERG11 0.003
761 Cytochrome P450 51 ERG11 0.003
3163 Cytochrome P450 51 cyp51 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
173 Toll-like receptor 7 TLR7 0.003
1024 Solute carrier family 22 member 11 SLC22A11 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
2112 Toll-like receptor 9 TLR9 0.0029
380 Cytochrome P450 17A1 CYP17A1 0.0029
6031 Cytochrome P450 3A43 CYP3A43 0.0029
504 Mast/stem cell growth factor receptor KIT 0.0029
6020 Aldehyde oxidase AOX1 0.0029
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0028
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0028
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0028
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0028
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0027
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3830 Calreticulin CALR 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
106 Cannabinoid receptor 2 CNR2 0.0026
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
756 Sex hormone-binding globulin SHBG 0.0025
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6102 Arylamine N-acetyltransferase 2 NAT2 0.0025
6034 Hydroxyindole O-methyltransferase ASMT 0.0025
6182 Cytochrome P450 2J2 CYP2J2 0.0025
6035 Nuclear receptor ROR-beta RORB 0.0025
6036 Eosinophil peroxidase EPX 0.0025
976 Platelet glycoprotein IX GP9 0.0025
68 Cannabinoid receptor 1 CNR1 0.0025
1374 Natriuretic peptides B NPPB 0.0024
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
716 5-hydroxytryptamine 7 receptor HTR7 0.0024
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0024
1063 Signal transducer and activator of transcription 5B STAT5B 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0024
4102 Proteasome subunit beta type 5 PSMB5 0.0024
4101 Proteasome subunit beta type 1 PSMB1 0.0024
6070 Nischarin NISCH 0.0024
482 Glycine receptor subunit alpha-1 GLRA1 0.0024
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0024
4192 DNA topoisomerase 2-beta TOP2B 0.0023
275 Arachidonate 5-lipoxygenase ALOX5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1569 G1/S-specific cyclin-D1 CCND1 0.0023
814 Ryanodine receptor 1 RYR1 0.0023
822 Aldose reductase AKR1B1 0.0023
904 Glutathione S-transferase P GSTP1 0.0023
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
6136 Multidrug resistance-associated protein 5 ABCC5 0.0022
84 Nuclear receptor 0B1 NR0B1 0.0022
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0022
1256 5-hydroxytryptamine 6 receptor HTR6 0.0022
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
634 Squalene monooxygenase SQLE 0.0022
7196 Squalene monooxygenase ERG1 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0022
765 Indoleamine 2,3-dioxygenase IDO1 0.0022
251 Alcohol dehydrogenase 1A ADH1A 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0022
908 Glutathione S-transferase theta-1 GSTT1 0.0021
731 HIV-1 protease HIV-1 protease 0.0021
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0021
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
6141 Sodium/bile acid cotransporter SLC10A1 0.0021
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.002
268 Adenosine A2b receptor ADORA2B 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
422 Vitamin K-dependent protein C PROC 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
859 Cellular retinoic acid-binding protein 2 CRABP2 0.002
6137 Multidrug resistance-associated protein 6 ABCC6 0.002
921 Glutamate receptor 2 GRIA2 0.002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.002
780 Retinoic acid receptor RXR-gamma RXRG 0.002
295 Carbonic anhydrase 1 CA1 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.002
936 Ephrin type-A receptor 2 EPHA2 0.002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
444 Alcohol dehydrogenase 1B ADH1B 0.0019
124 Histamine H2 receptor HRH2 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
183 Vascular endothelial growth factor A VEGFA 0.0019
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0019
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0019
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0018
6163 Copper-transporting ATPase 2 ATP7B 0.0018
6165 Copper-transporting ATPase 1 ATP7A 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
239 Coagulation factor X F10 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0018
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0018
1992 Vitamin D-binding protein GC 0.0018
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0018
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0018
88 Retinoic acid receptor RXR-beta RXRB 0.0018
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0017
162 Retinoic acid receptor gamma-1 RARG 0.0017
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0017
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0017
1648 Elastin ELN 0.0017
1275 Estrogen sulfotransferase SULT1E1 0.0017
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0017
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0017
1656 CYP2B protein CYP2B 0.0017
4604 Liver carboxylesterase 1 CES1 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0016
1830 5'-nucleotidase NT5E 0.0016
798 Osteocalcin BGLAP 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
1050 Bile salt sulfotransferase SULT2A1 0.0016
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0016
1243 Cathepsin D CTSD 0.0016
751 Potassium channel subfamily K member 6 KCNK6 0.0016
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0016
4120 NADPH--cytochrome P450 reductase POR 0.0016
474 Acetylcholinesterase ACHE 0.0016
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0016
427 Substance-P receptor TACR1 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0015
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0015
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0015
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
369 Coagulation factor VII F7 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
172 Potassium channel subfamily K member 1 KCNK1 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0015
3937 Fatty-acid amide hydrolase FAAH 0.0015
6432 Transporter snf 0.0015
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
528 5-hydroxytryptamine 1E receptor HTR1E 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
847 Mu-type opioid receptor OPRM1 0.0014
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0013
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0013
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0013
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0013
856 Vitamin D3 receptor VDR 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
696 Kappa-type opioid receptor OPRK1 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0012
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0012
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0012
997 Protein kinase C beta type PRKCB 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
737 Mineralocorticoid receptor NR3C2 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0012
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
518 Peroxidase/catalase T katG 0.0012
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0012
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
563 Thyroid peroxidase TPO 0.0011
3007 Carbonic anhydrase 12 CA12 0.0011
4205 Carbonic anhydrase 9 CA9 0.0011
614 Progesterone receptor PGR 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
467 Delta-type opioid receptor OPRD1 0.0011
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
6126 Carbonic anhydrase 7 CA7 0.001
4237 50S ribosomal protein L22 rplV 0.001
6085 Fatty acid-binding protein, intestinal FABP2 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
345 Plasma retinol-binding protein RBP4 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
2981 Phospholipase A2, membrane associated PLA2G2A 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
164 Histamine H4 receptor HRH4 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
229 Retinoic acid receptor beta RARB 0.0009
54 Prothrombin F2 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
469 Annexin A1 ANXA1 0.0009
365 Dihydrofolate reductase DHFR 0.0009
2381 Dihydrofolate reductase DFR1 0.0009
2833 Dihydrofolate reductase Not Available 0.0009
2931 Dihydrofolate reductase folA 0.0009
3544 Dihydrofolate reductase folA 0.0009
3682 Dihydrofolate reductase folA 0.0009
6642 Dihydrofolate reductase folA 0.0009
6756 Dihydrofolate reductase dfrA 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
592 Carbonic anhydrase 4 CA4 0.0008
7 Nitric oxide synthase, inducible NOS2 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
1618 High affinity nerve growth factor receptor NTRK1 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
811 Translocator protein TSPO 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
4226 Uridine phosphorylase 2 UPP2 0.0007
3810 Catechol O-methyltransferase COMT 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0007
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
357 Carbonic anhydrase 2 CA2 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0006
1864 RET proto-oncogene RET 0.0006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
165 FL cytokine receptor FLT3 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0004
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
738 Monocarboxylate transporter 1 SLC16A1 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
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