DT-Web: DB00499

Identification

Name

Flutamide

Accession Number

DB00499 (APRD00984)

Type

small molecule

Description

An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

276.2118

Groups

approved

Monoisotopic Weight

276.072176843

Pharmacology

Indication

For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate

Mechanism of action

Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen.

Absorption

Rapidly and completely absorbed.

Protein binding

94-96%

Biotransformation

Flutamide is rapidly and extensively metabolized, with flutamide comprising only 2.5% of plasma radioactivity 1 hour after administration.

Route of elimination

Flutamide and its metabolites are excreted mainly in the urine with only 4.2% of a single dose excreted in the feces over 72 hours.

Toxicity

In animal studies with flutamide alone, signs of overdose included hypoactivity, piloerection, slow respiration, ataxia, and/or lacrimation, anorexia, tranquilization, emesis, and methemoglobinemia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Telithromycin	Telithromycin may reduce clearance of Flutamide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Flutamide if Telithromycin is initiated, discontinued or dose changed.
Thiabendazole	The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Flutamide by decreasing Flutamide metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Flutamide if Thiabendazole is initiated, discontinued or dose changed.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of flutamide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of flutamide if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Take without regard to meals.

Androgen receptor
Name	Androgen receptor
Gene Name	AR
Pharmacological action	yes
Actions	antagonist
References	Chang HC, Miyamoto H, Marwah P, Lardy H, Yeh S, Huang KE, Chang C: Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11173-7. - Pubmed Martelli A, Campart GB, Carrozzino R, Ghia M, Mattioli F, Mereto E, Orsi P, Puglia CP: Evaluation of flutamide genotoxicity in rats and in primary human hepatocytes. Pharmacol Toxicol. 2000 Mar;86(3):129-34. - Pubmed Montalvo L, Carmena MJ, Solano RM, Clemente C, Roman ID, Sanchez-Chapado M, Prieto JC: Effect of flutamide-induced androgen-receptor blockade on adenylate cyclase activation through G-protein coupled receptors in rat prostate. Cell Signal. 2000 May;12(5):311-6. - Pubmed Pazos F, Sanchez-Franco F, Balsa JA, Escalada J, Palacios N, Cacicedo L: Mechanisms of reduced body growth in the pubertal feminized male rat: unbalanced estrogen and androgen action on the somatotropic axis. Pediatr Res. 2000 Jul;48(1):96-103. - Pubmed Shilling AD, Williams DE: The non-aromatizable androgen, dihydrotestosterone, induces antiestrogenic responses in the rainbow trout. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):187-94. - Pubmed Balk SP: Androgen receptor as a target in androgen-independent prostate cancer. Urology. 2002 Sep;60(3 Suppl 1):132-8; discussion 138-9. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.0674
Aryl hydrocarbon receptor
Name	Aryl hydrocarbon receptor
Gene Name	AHR
Pharmacological action	unknown
Actions	agonist
References	Hu W, Sorrentino C, Denison MS, Kolaja K, Fielden MR: Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol. 2007 Jun;71(6):1475-86. Epub 2007 Feb 27. - Pubmed
DTHybrid score	0.2776

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6008
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Shet MS, McPhaul M, Fisher CW, Stallings NR, Estabrook RW: Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2. Drug Metab Dispos. 1997 Nov;25(11):1298-303. - Pubmed
DTHybrid score	0.4686
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3056
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.191
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.359
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3338

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.2912
4119	Cytochrome P450 2D6	CYP2D6	0.2835
1588	Multidrug resistance protein 1	ABCB1	0.2345
4924	Cytochrome P450 2C8	CYP2C8	0.1983
6107	Cytochrome P450 3A7	CYP3A7	0.1866
6030	Cytochrome P450 2B6	CYP2B6	0.1636
6013	Cytochrome P450 2E1	CYP2E1	0.1593
1159	Interleukin-6	IL6	0.1354
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1176
3811	Cytochrome P450 19A1	CYP19A1	0.1074
5718	Cytochrome P450 2A6	CYP2A6	0.0908
290	Prostaglandin G/H synthase 2	PTGS2	0.0831
587	Serum albumin	ALB	0.0764
20	Prostaglandin G/H synthase 1	PTGS1	0.062
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0619
862	Multidrug resistance-associated protein 1	ABCC1	0.0548
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0547
6106	Cytochrome P450 2C18	CYP2C18	0.0528
756	Sex hormone-binding globulin	SHBG	0.0528
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0528
737	Mineralocorticoid receptor	NR3C2	0.0525
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.052
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0517
136	Estrogen receptor	ESR1	0.0487
871	Glucocorticoid receptor	NR3C1	0.048
614	Progesterone receptor	PGR	0.0444
492	Histamine H1 receptor	HRH1	0.0428
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0427
992	Protein tyrosine kinase 2 beta	PTK2B	0.0424
6145	Solute carrier family 22 member 1	SLC22A1	0.0411
776	Bile salt export pump	ABCB11	0.0406
1729	Solute carrier family 22 member 6	SLC22A6	0.0387
6144	Solute carrier family 22 member 2	SLC22A2	0.038
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0378
468	Cytochrome P450 4A11	CYP4A11	0.035
824	Sodium-dependent serotonin transporter	SLC6A4	0.0346
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0341
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.033
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0329
817	DNA topoisomerase 2-alpha	TOP2A	0.0324
3947	Xanthine dehydrogenase/oxidase	XDH	0.0319
318	Alpha-2A adrenergic receptor	ADRA2A	0.0311
502	5-hydroxytryptamine 2A receptor	HTR2A	0.031
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0307
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0304
831	D(2) dopamine receptor	DRD2	0.0302
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0302
556	Alpha-1A adrenergic receptor	ADRA1A	0.0301
3941	Amine oxidase [flavin-containing] A	MAOA	0.03
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0297
6142	Solute carrier family 22 member 8	SLC22A8	0.0285
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0284
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0269
6031	Cytochrome P450 3A43	CYP3A43	0.0266
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0264
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0263
36	Insulin receptor	INSR	0.0258
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0256
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0255
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0248
6147	Solute carrier family 22 member 3	SLC22A3	0.0247
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0247
6143	Solute carrier family 22 member 7	SLC22A7	0.0245
260	Cytochrome P450 51	ERG11	0.0245
761	Cytochrome P450 51	ERG11	0.0245
3163	Cytochrome P450 51	cyp51	0.0245
6148	Multidrug resistance-associated protein 7	ABCC10	0.0241
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0239
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0239
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0238
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0237
23	D(1A) dopamine receptor	DRD1	0.0236
766	Beta-2 adrenergic receptor	ADRB2	0.0233
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0231
590	5-hydroxytryptamine 2C receptor	HTR2C	0.023
632	Alpha-1B adrenergic receptor	ADRA1B	0.0224
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0224
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0223
731	HIV-1 protease	HIV-1 protease	0.0219
3939	Amine oxidase [flavin-containing] B	MAOB	0.0219
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0217
193	Beta-1 adrenergic receptor	ADRB1	0.0214
118	Organic cation/carnitine transporter 2	SLC22A5	0.0213
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0211
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0208
2164	Multidrug resistance-associated protein 4	ABCC4	0.0205
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0205
6014	Cytochrome P450 2A13	CYP2A13	0.0202
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0201
777	Tumor necrosis factor	TNF	0.0198
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0197
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0195
713	Sodium-dependent dopamine transporter	SLC6A3	0.0194
847	Mu-type opioid receptor	OPRM1	0.0192
638	D(3) dopamine receptor	DRD3	0.0187
477	DNA topoisomerase 4 subunit A	parC	0.0186
886	DNA topoisomerase 4 subunit A	parC	0.0186
6226	DNA topoisomerase 4 subunit A	parC	0.0186
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0185
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0184
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0184
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0184
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0184
404	DNA gyrase subunit A	gyrA	0.0183
6224	DNA gyrase subunit A	gyrA	0.0183
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0183
4228	Keratin, type II cytoskeletal 7	KRT7	0.0177
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0177
4120	NADPH--cytochrome P450 reductase	POR	0.0176
380	Cytochrome P450 17A1	CYP17A1	0.0174
844	Epidermal growth factor receptor	EGFR	0.0174
833	Organic cation/carnitine transporter 1	SLC22A4	0.0173
629	Alpha-2B adrenergic receptor	ADRA2B	0.0173
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0172
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0172
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.017
373	Transthyretin	TTR	0.0169
16	Adenosine A1 receptor	ADORA1	0.0167
3923	Cholinesterase	BCHE	0.0166
465	Calmodulin	CALM1	0.0162
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0162
274	Muscarinic acetylcholine receptor M5	CHRM5	0.016
378	Alpha-2C adrenergic receptor	ADRA2C	0.0159
6182	Cytochrome P450 2J2	CYP2J2	0.0157
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0156
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0155
789	Alpha-1D adrenergic receptor	ADRA1D	0.0154
1178	Adenosine A2a receptor	ADORA2A	0.0152
467	Delta-type opioid receptor	OPRD1	0.015
1757	Myeloperoxidase	MPO	0.0143
6136	Multidrug resistance-associated protein 5	ABCC5	0.0143
571	Melatonin receptor type 1A	MTNR1A	0.0143
362	Melatonin receptor type 1B	MTNR1B	0.0143
4203	Histamine N-methyltransferase	HNMT	0.014
6241	Nuclear receptor coactivator 2	NCOA2	0.0137
3810	Catechol O-methyltransferase	COMT	0.0136
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0134
6137	Multidrug resistance-associated protein 6	ABCC6	0.0133
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0133
696	Kappa-type opioid receptor	OPRK1	0.0133
381	Prolactin receptor	PRLR	0.013
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0128
432	D(4) dopamine receptor	DRD4	0.0127
232	Corticosteroid-binding globulin	SERPINA6	0.0127
1010	Cytochrome P450 51A1	CYP51A1	0.0126
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0125
122	P2Y purinoceptor 12	P2RY12	0.0124
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
273	Apoptosis regulator Bcl-2	BCL2	0.0122
29	Tubulin beta-1 chain	TUBB1	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
504	Mast/stem cell growth factor receptor	KIT	0.0121
952	Dipeptidyl peptidase 4	DPP4	0.0118
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0118
818	50S ribosomal protein L10	rplJ	0.0118
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0117
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0117
48	Pyridoxal kinase	PDXK	0.0116
1517	Beta-3 adrenergic receptor	ADRB3	0.0116
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0115
6141	Sodium/bile acid cotransporter	SLC10A1	0.0114
2499	Tubulin beta-2C chain	TUBB2C	0.0113
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0112
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0111
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0111
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0109
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0108
2449	Tubulin alpha-3 chain	TUBA1A	0.0107
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0107
814	Ryanodine receptor 1	RYR1	0.0103
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0102
1714	Mitogen-activated protein kinase 3	MAPK3	0.0101
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0099
4122	Histone deacetylase 2	HDAC2	0.0099
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0099
1852	Microtubule-associated protein 2	MAP2	0.0097
1024	Solute carrier family 22 member 11	SLC22A11	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
4604	Liver carboxylesterase 1	CES1	0.0096
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0096
716	5-hydroxytryptamine 7 receptor	HTR7	0.0096
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0096
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0095
869	Estrogen receptor beta	ESR2	0.0095
5923	Microtubule-associated protein tau	MAPT	0.0095
5924	Microtubule-associated protein 4	MAP4	0.0095
124	Histamine H2 receptor	HRH2	0.0094
26	Vascular endothelial growth factor receptor 3	FLT4	0.0093
1629	Transcription factor AP-1	JUN	0.0092
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0092
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0092
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0089
32	Vascular endothelial growth factor receptor 1	FLT1	0.0088
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0088
407	Vascular endothelial growth factor receptor 2	KDR	0.0087
33	Cystine/glutamate transporter	SLC7A11	0.0087
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0087
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0086
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0086
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0086
811	Translocator protein	TSPO	0.0085
1569	G1/S-specific cyclin-D1	CCND1	0.0085
790	DNA polymerase subunit alpha B	POLA2	0.0084
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0084
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0083
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0083
6020	Aldehyde oxidase	AOX1	0.0083
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0083
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0083
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0083
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0083
2236	Casein kinase II subunit alpha	CSNK2A1	0.0082
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0082
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0082
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0082
6146	High affinity copper uptake protein 1	SLC31A1	0.008
3830	Calreticulin	CALR	0.008
3932	Glutathione S-transferase A2	GSTA2	0.008
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.008
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0079
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0079
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0077
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0077
1656	CYP2B protein	CYP2B	0.0077
1176	Mitogen-activated protein kinase 1	MAPK1	0.0077
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0076
4311	tRNA	TRDMT1	0.0075
4325	tRNA	trmD	0.0075
4328	tRNA	trmD	0.0075
6034	Hydroxyindole O-methyltransferase	ASMT	0.0074
6035	Nuclear receptor ROR-beta	RORB	0.0074
6036	Eosinophil peroxidase	EPX	0.0074
4192	DNA topoisomerase 2-beta	TOP2B	0.0074
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0074
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0074
705	Glutamate receptor 1	GRIA1	0.0073
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0073
68	Cannabinoid receptor 1	CNR1	0.0073
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0072
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0071
823	Fibroblast growth factor receptor 2	FGFR2	0.0071
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0071
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0071
1649	Small inducible cytokine A2	CCL2	0.007
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
936	Ephrin type-A receptor 2	EPHA2	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
6043	Putative G-protein coupled receptor 44	GPR44	0.007
84	Nuclear receptor 0B1	NR0B1	0.0069
427	Substance-P receptor	TACR1	0.0069
1192	Sulfotransferase 1A1	SULT1A1	0.0069
921	Glutamate receptor 2	GRIA2	0.0069
163	D(1B) dopamine receptor	DRD5	0.0069
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0069
6102	Arylamine N-acetyltransferase 2	NAT2	0.0069
5934	Cytochrome P450 26A1	CYP26A1	0.0068
2539	Tubulin alpha-1 chain	TUBA4A	0.0068
904	Glutathione S-transferase P	GSTP1	0.0067
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0067
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0067
70	Type-1 angiotensin II receptor	AGTR1	0.0067
820	Glycine receptor subunit alpha-2	GLRA2	0.0066
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0065
239	Coagulation factor X	F10	0.0065
765	Indoleamine 2,3-dioxygenase	IDO1	0.0065
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0065
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0064
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0064
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0064
592	Carbonic anhydrase 4	CA4	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
161	Tubulin beta chain	TUBB	0.0064
312	Tubulin beta chain	TUB2	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0063
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0062
94	5-hydroxytryptamine 4 receptor	HTR4	0.0062
484	Tyrosine-protein kinase ABL2	ABL2	0.0062
295	Carbonic anhydrase 1	CA1	0.0062
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0062
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0061
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0061
469	Annexin A1	ANXA1	0.006
4237	50S ribosomal protein L22	rplV	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0059
908	Glutathione S-transferase theta-1	GSTT1	0.0058
268	Adenosine A2b receptor	ADORA2B	0.0058
6766	O-GlcNAcase BT_4395	BT_4395	0.0058
723	Cytosolic phospholipase A2	PLA2G4A	0.0058
284	DNA-directed RNA polymerase beta chain	rpoB	0.0057
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0057
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0057
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0056
5300	Antigen peptide transporter 1	TAP1	0.0056
3957	Adenosine deaminase	ADA	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0056
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0056
856	Vitamin D3 receptor	VDR	0.0055
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0055
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0055
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0055
2112	Toll-like receptor 9	TLR9	0.0054
5998	Toll-like receptor 8	TLR8	0.0053
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
49	Endothelin B receptor	EDNRB	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3426	Glutamine synthetase	glnA	0.0052
3987	Glutamine synthetase	GLUL	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
275	Arachidonate 5-lipoxygenase	ALOX5	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
183	Vascular endothelial growth factor A	VEGFA	0.0051
768	FK506-binding protein 1A	FKBP1A	0.005
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.005
3937	Fatty-acid amide hydrolase	FAAH	0.005
578	Endothelin-1 receptor	EDNRA	0.0049
474	Acetylcholinesterase	ACHE	0.0049
7	Nitric oxide synthase, inducible	NOS2	0.0049
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0048
6163	Copper-transporting ATPase 2	ATP7B	0.0048
6165	Copper-transporting ATPase 1	ATP7A	0.0048
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0048
976	Platelet glycoprotein IX	GP9	0.0048
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0047
357	Carbonic anhydrase 2	CA2	0.0047
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0047
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0047
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0047
6044	Serum paraoxonase/lactonase 3	PON3	0.0047
106	Cannabinoid receptor 2	CNR2	0.0046
896	Glutathione S-transferase Mu 1	GSTM1	0.0046
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0046
173	Toll-like receptor 7	TLR7	0.0046
54	Prothrombin	F2	0.0045
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0045
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0045
6085	Fatty acid-binding protein, intestinal	FABP2	0.0045
4238	50S ribosomal protein L4	rplD	0.0045
5578	50S ribosomal protein L4	rplD	0.0045
6173	50S ribosomal protein L4	rplD	0.0045
6219	50S ribosomal protein L4	rplD	0.0045
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0045
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0044
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0044
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0044
581	Cytochrome P450 2R1	CYP2R1	0.0044
1483	Membrane copper amine oxidase	AOC3	0.0043
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0043
461	Glycine receptor subunit alpha-3	GLRA3	0.0043
153	Dopamine beta-hydroxylase	DBH	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0042
482	Glycine receptor subunit alpha-1	GLRA1	0.0042
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0041
165	FL cytokine receptor	FLT3	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0039
1618	High affinity nerve growth factor receptor	NTRK1	0.0039
634	Squalene monooxygenase	SQLE	0.0039
7196	Squalene monooxygenase	ERG1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6432	Transporter	snf	0.0039
780	Retinoic acid receptor RXR-gamma	RXRG	0.0038
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0038
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0038
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0038
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0038
85	Growth hormone receptor	GHR	0.0038
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0036
4103	Proteasome subunit beta type 2	PSMB2	0.0036
4102	Proteasome subunit beta type 5	PSMB5	0.0036
6126	Carbonic anhydrase 7	CA7	0.0036
4101	Proteasome subunit beta type 1	PSMB1	0.0036
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0036
6174	50S ribosomal protein L32	rpmF	0.0035
164	Histamine H4 receptor	HRH4	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0035
88	Retinoic acid receptor RXR-beta	RXRB	0.0035
569	Retinal dehydrogenase 2	ALDH1A2	0.0035
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0034
1196	Complement decay-accelerating factor	CD55	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
1050	Bile salt sulfotransferase	SULT2A1	0.0033
251	Alcohol dehydrogenase 1A	ADH1A	0.0033
611	Retinal dehydrogenase 1	ALDH1A1	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
3086	Plasmepsin-2	Not Available	0.0032
518	Peroxidase/catalase T	katG	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
1992	Vitamin D-binding protein	GC	0.0031
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0031
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0031
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0031
738	Monocarboxylate transporter 1	SLC16A1	0.0031
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0031
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0031
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0031
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0031
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
543	Penicillin-binding protein 1B	mrcB	0.003
6186	Penicillin-binding protein 1B	ponB	0.003
6822	Penicillin-binding protein 1b	pbp1b	0.003
6844	Penicillin-binding protein 1b	pbp1b	0.003
365	Dihydrofolate reductase	DHFR	0.003
2381	Dihydrofolate reductase	DFR1	0.003
2833	Dihydrofolate reductase	Not Available	0.003
2931	Dihydrofolate reductase	folA	0.003
3544	Dihydrofolate reductase	folA	0.003
3682	Dihydrofolate reductase	folA	0.003
6642	Dihydrofolate reductase	folA	0.003
6756	Dihydrofolate reductase	dfrA	0.003
2808	Chloramphenicol acetyltransferase 3	cat3	0.003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.003
159	Penicillin-binding protein 2B	penA	0.0029
6121	Penicillin-binding protein 2B	penA	0.0029
267	Plasminogen activator inhibitor 1	SERPINE1	0.0029
563	Thyroid peroxidase	TPO	0.0029
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0029
891	Dihydropteroate synthase	folP	0.0029
5359	Dihydropteroate synthase	folP	0.0029
7175	Dihydropteroate synthase	sulI	0.0029
444	Alcohol dehydrogenase 1B	ADH1B	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1374	Natriuretic peptides B	NPPB	0.0028
1827	Gap junction alpha-1 protein	GJA1	0.0028
1908	Vascular cell adhesion protein 1	VCAM1	0.0028
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0028
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0028
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0028
3601	Dihydropteroate synthase 1	folP1	0.0027
3807	Dihydropteroate synthase 1	folP1	0.0027
3808	Dihydropteroate synthase 2	folP2	0.0027
2417	Chloramphenicol acetyltransferase	cat	0.0027
3278	Chloramphenicol acetyltransferase	cat	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2810	Dr hemagglutinin structural subunit	draA	0.0027
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
770	Retinoic acid-induced protein 3	GPRC5A	0.0027
719	Retinoic acid receptor responder protein 1	RARRES1	0.0027
6221	Steroid hormone receptor ERR1	ESRRA	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
1648	Elastin	ELN	0.0026
6131	Carbonic anhydrase 14	CA14	0.0026
3913	Glutamic acid decarboxylase	GAD65	0.0026
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0025
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0025
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0025
162	Retinoic acid receptor gamma-1	RARG	0.0025
517	Alcohol dehydrogenase 1C	ADH1C	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
6168	Solute carrier family 22 member 16	SLC22A16	0.0025
3809	Estrogen-related receptor gamma	ESRRG	0.0025
400	Coagulation factor IX	F9	0.0024
5461	Coagulation factor IX	F9	0.0024
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0024
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0024
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0024
319	Opioid receptor, sigma 1	OPRS1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6122	Carbonic anhydrase 3	CA3	0.0024
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
3856	Fibroblast growth factor receptor 3	FGFR3	0.0024
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
131	Synaptic vesicular amine transporter	SLC18A2	0.0023
1830	5'-nucleotidase	NT5E	0.0023
1630	Integrin beta-2	ITGB2	0.0023
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0023
822	Aldose reductase	AKR1B1	0.0023
5787	Angiopoietin-1 receptor	TEK	0.0023
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0022
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0022
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0022
604	Vitamin K-dependent protein Z	PROZ	0.0022
1864	RET proto-oncogene	RET	0.0022
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0022
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0022
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0022
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
3904	Alanine aminotransferase 2	GPT2	0.0021
735	Alanine aminotransferase 1	GPT	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
291	Nitric-oxide synthase, endothelial	NOS3	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0021
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0021
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
1353	DNA topoisomerase 1	TOP1	0.0021
3552	DNA topoisomerase 1	topA	0.0021
4773	Deoxycytidine kinase	DCK	0.0021
422	Vitamin K-dependent protein C	PROC	0.002
1245	Vitamin K-dependent protein S	PROS1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
174	Sigma 1-type opioid receptor	SIGMAR1	0.002
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.002
1275	Estrogen sulfotransferase	SULT1E1	0.002
1039	Histone deacetylase 9	HDAC9	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0019
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0019
1525	Heparin-binding growth factor 2	FGF2	0.0019
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
751	Potassium channel subfamily K member 6	KCNK6	0.0019
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0019
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
558	Solute carrier family 12 member 1	SLC12A1	0.0018
1253	Interferon gamma	IFNG	0.0018
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0018
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
683	Potassium transporter	GK0582	0.0018
459	Retinoic acid receptor RXR-alpha	RXRA	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0017
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0017
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0017
572	Integrin alpha-L	ITGAL	0.0017
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0017
172	Potassium channel subfamily K member 1	KCNK1	0.0017
6824	Tyrosine-protein kinase Lyn	LYN	0.0017
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0017
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0016
798	Osteocalcin	BGLAP	0.0016
76	Nitric-oxide synthase, brain	NOS1	0.0016
1243	Cathepsin D	CTSD	0.0016
3007	Carbonic anhydrase 12	CA12	0.0016
4205	Carbonic anhydrase 9	CA9	0.0016
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0016
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0015
3233	Bile acid receptor	NR1H4	0.0015
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0015
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0015
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0015
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
369	Coagulation factor VII	F7	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1541	Metalloproteinase	mmp20	0.0014
6167	Organic solute transporter subunit beta	OSTB	0.0014
6166	Organic solute transporter subunit alpha	OSTA	0.0014
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0014
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0014
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0014
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0014
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0014
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0014
65	Matrix metalloproteinase-9	Not Available	0.0014
6859	Protein S100-A4	S100A4	0.0014
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0014
2216	Fibroblast growth factor receptor 4	FGFR4	0.0014
2300	Lysozyme	E	0.0014
3633	Lysozyme	R	0.0014
5597	Lysozyme	17	0.0014
6149	Solute carrier family 22 member 10	SLC22A10	0.0014
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0013
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
1650	Heme carrier protein 1	SLC46A1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6048	Troponin C, skeletal muscle	TNNC2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0012
4217	Telomerase reverse transcriptase	TERT	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
24	Thymidylate synthase	TMP1	0.0011
359	Thymidylate synthase	TYMS	0.0011
2626	Thymidylate synthase	thyA	0.0011
2729	Thymidylate synthase	thyA	0.0011
5352	Thymidylate synthase	THYA	0.0011
2408	Tyrosine-protein kinase SYK	SYK	0.0011
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5798	Mitogen-activated protein kinase 11	MAPK11	0.0009
2320	Thymidine kinase, cytosolic	TK1	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
6218	Pannexin-1	PANX1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
760	Fibroblast growth factor 1	FGF1	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2298	Cytochrome P450-cam	camC	0.0007
2021	Thrombomodulin	THBD	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
489	Monocarboxylate transporter 2	SLC16A7	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
6042	Prostaglandin reductase 2	PTGR2	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
1792	Tissue-type plasminogen activator	PLAT	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
1313	Lactoylglutathione lyase	GLO1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
2207	Rhodopsin	RHO	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00499 - Flutamide

Targets

Enzymes

Predictions