DT-Web: DB01142

Identification

Name

Doxepin

Accession Number

DB01142 (APRD00398)

Type

small molecule

Description

Doxepin hydrochloride is a dibenzoxepin-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, doxepin does not affect mood or arousal, but may cause sedation. In depressed individuals, doxepin exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as doxepin and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Doxepin has less sedative and anticholinergic effects than amitriptyline. See toxicity section below for a complete listing of side effects. Doxepin may be used to treat depression and insomnia. Unlabeled indications include chronic and neuropathic pain, and anxiety. Doxepin may also be used as a second line agent to treat idiopathic urticaria.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

279.3761

Groups

approved

Monoisotopic Weight

279.162314299

Pharmacology

Indication

Doxepin is used for the treatment of depression and/or anxiety. It can also be used for chronic urticaria and in the management of pain.

Mechanism of action

The mechanism of action of doxepin is not completely understood. It is thought that like amitriptyline, doxepin enhances the actions of norepinephrine and serotonin by blocking their reuptake at the neuronal membrane. However, doxepin weakly inhibits the reuptake of dopamine. Doxepin may also act on histamine H₁-receptors, resulting in sedative effects, and β-adrenergic receptors. It is also an antagonist of 5-hydroxytryptamine (serotonin) receptors, alpha-1 adrenergic receptor, and muscarinic cholinergic receptors.

Absorption

Well-absorbed from the GI tract. Peak plasma concentrations occur within 2 hours of oral administration.

Protein binding

Doxepin and desmethyldoxepin is 80% protein bound. It is also a lipophillic drug and is capable of crossing the blood-brain-barrier.

Biotransformation

Extensively metabolized in the liver via the same pathways as other TCAs. N-demethylation produces an active metabolite, N-desmethyldoxepin. CYP2D6 specifically hydroxylates the E-isomer.

Route of elimination

Not Available

Toxicity

LD₅₀=26 (mg/kg) (in mice, iv); LD₅₀=16 (mg/kg) (in rats, iv); Cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Altretamine	Risk of severe hypotension
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir	Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if atazanavir if initiated, discontinued or dose changed.
Butabarbital	Barbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like doxepin. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Butalbital	Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants such as doxepin. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Carbamazepine	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, doxepin, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if carbamazepine is initiated, discontinued or dose changed.
Cimetidine	Cimetidine may increase the effect of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if cimetidine is initiated, discontinued or dose changed.
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Clonidine	The tricyclic antidepressant, doxepin, decreases the effect of clonidine.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroquinidine barbiturate	Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, doxepin.
Dobutamine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of dobutamine.
Donepezil	Possible antagonism of action
Dopamine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of dopamine.
Ephedra	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of ephedra.
Ephedrine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of ephedrine.
Epinephrine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of epinephrine.
Fenoterol	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of fenoterol.
Fluoxetine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of doxepin if fluoxetine is initiated, discontinued or dose changed.
Fluvoxamine	The SSRI, fluvoxamine, may increase the serum concentration of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of doxepin if fluvoxamine is initiated, discontinued or dose changed.
Galantamine	Possible antagonism of action
Grepafloxacin	Increased risk of cardiotoxicity and arrhythmias
Guanethidine	The tricyclic antidepressant, doxepin, decreases the effect of guanethidine.
Isocarboxazid	Possibility of severe adverse effects
Isoproterenol	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of isoproterenol.
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mephentermine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of mephentermine.
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Metaraminol	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of metaraminol.
Methoxamine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of methoxamine.
Moclobemide	Possible severe adverse reaction with this combination
Norepinephrine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of norepinephrine.
Orciprenaline	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of orciprenaline.
Phenelzine	Possibility of severe adverse effects
Phenylephrine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of phenylephrine.
Phenylpropanolamine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of phenylpropanolamine.
Pirbuterol	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of pirbuterol.
Procaterol	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of procaterol.
Pseudoephedrine	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of pseudoephedrine.
Quinidine	Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Quinidine barbiturate	Quinidine barbiturate increases the effect of tricyclic antidepressant, doxepin.
Rasagiline	Possibility of severe adverse effects
Rifabutin	The rifamycin, rifabutin, may decrease the effect of the tricyclic antidepressant, doxepin, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if rifabutin is initiated, discontinued or dose changed.
Rifampin	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, doxepin, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if rifampin is initiated, discontinued or dose changed.
Ritonavir	Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if ritonavir if initiated, discontinued or dose changed.
Rivastigmine	Possible antagonism of action
Salbutamol	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of salbutamol.
Sibutramine	Increased risk of CNS adverse effects
Sparfloxacin	Increased risk of cardiotoxicity and arrhythmias
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Doxepin, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telithromycin	Telithromycin may reduce clearance of Doxepin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Doxepin if Telithromycin is initiated, discontinued or dose changed.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Doxepin. Consider alternate therapy or monitor for therapeutic/adverse effects of Amytriptyline if Doxepin is initiated, discontinued or dose changed.
Terbutaline	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of terbutaline.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Thiabendazole	The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Doxepin by decreasing Doxepin metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Doxepin if Thiabendazole is initiated, discontinued or dose changed.
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	Tramadol increases the risk of serotonin syndrome and seizures.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimethobenzamide	Trimethobenzamide and Doxepin, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome. Additive QTc-prolongation may also occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine	Triprolidine and Doxepin, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Doxepin, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole	Additive QTc prolongation may occur. Voriconazole, a strong CYP3A4 inhibitor, may also increase the serum concentration of doxepin by decreasing its metabolism. Consider alternate therapy or monitor for QTc prolongation and changes in the therapeutic and adverse effects of doxepin if voriconazole is initiated, discontinued or dose changed.
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and doxepin, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Avoid excessive quantities of coffee or tea (Caffeine).
Take with food to reduce irritation.
Avoid St.John's Wort.
Avoid alcohol.

Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	yes
Actions	antagonist
References	Tashiro M, Sakurada Y, Iwabuchi K, Mochizuki H, Kato M, Aoki M, Funaki Y, Itoh M, Iwata R, Wong DF, Yanai K: Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol. 2004 Aug;44(8):890-900. - Pubmed Tran VT, Lebovitz R, Toll L, Snyder SH: [3H]doxepin interactions with histamine H1-receptors and other sites in guinea pig and rat brain homogenates. Eur J Pharmacol. 1981 Apr 9;70(4):501-9. - Pubmed Kano M, Fukudo S, Tashiro A, Utsumi A, Tamura D, Itoh M, Iwata R, Tashiro M, Mochizuki H, Funaki Y, Kato M, Hongo M, Yanai K: Decreased histamine H1 receptor binding in the brain of depressed patients. Eur J Neurosci. 2004 Aug;20(3):803-10. - Pubmed Claro E, Arbones L, Garcia A, Picatoste F: Phosphoinositide hydrolysis mediated by histamine H1-receptors in rat brain cortex. Eur J Pharmacol. 1986 Apr 16;123(2):187-96. - Pubmed Richelson E, Nelson A: Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J Pharmacol Exp Ther. 1984 Jul;230(1):94-102. - Pubmed Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Stahl SM: Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr. 2008 Dec;13(12):1027-38. - Pubmed Singh H, Becker PM: Novel therapeutic usage of low-dose doxepin hydrochloride. Expert Opin Investig Drugs. 2007 Aug;16(8):1295-305. - Pubmed Figueiredo A, Ribeiro CA, Goncalo M, Almeida L, Poiares-Baptista A, Teixeira F: Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.9389
Histamine H2 receptor
Name	Histamine H2 receptor
Gene Name	HRH2
Pharmacological action	yes
Actions	antagonist
References	Beil W, Hannemann H, Sewing KF: Interaction of antidepressants and neuroleptics with histamine stimulated parietal cell adenylate cyclase and H+ secretion. Pharmacology. 1988;36(3):198-203. - Pubmed Figueiredo A, Ribeiro CA, Goncalo M, Almeida L, Poiares-Baptista A, Teixeira F: Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. - Pubmed
DTHybrid score	0.6278
Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed Stahl SM: Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr. 2008 Dec;13(12):1027-38. - Pubmed
DTHybrid score	0.7529
Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed Stahl SM: Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr. 2008 Dec;13(12):1027-38. - Pubmed
DTHybrid score	0.627
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Maj J, Gancarczyk L, Gorszczyk L, Rawlow A: Doxepin as a blocker of central serotonin receptors. Pharmakopsychiatr Neuropsychopharmakol. 1977 Dec;10(6):318-24. - Pubmed Stahl SM: Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr. 2008 Dec;13(12):1027-38. - Pubmed
DTHybrid score	0.8465
5-hydroxytryptamine 2B receptor
Name	5-hydroxytryptamine 2B receptor
Gene Name	HTR2B
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Maj J, Gancarczyk L, Gorszczyk L, Rawlow A: Doxepin as a blocker of central serotonin receptors. Pharmakopsychiatr Neuropsychopharmakol. 1977 Dec;10(6):318-24. - Pubmed
DTHybrid score	0.4065
5-hydroxytryptamine 2C receptor
Name	5-hydroxytryptamine 2C receptor
Gene Name	HTR2C
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Maj J, Gancarczyk L, Gorszczyk L, Rawlow A: Doxepin as a blocker of central serotonin receptors. Pharmakopsychiatr Neuropsychopharmakol. 1977 Dec;10(6):318-24. - Pubmed
DTHybrid score	0.6288
Muscarinic acetylcholine receptor M1
Name	Muscarinic acetylcholine receptor M1
Gene Name	CHRM1
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Stahl SM: Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr. 2008 Dec;13(12):1027-38. - Pubmed Ehlert FJ, Delen FM, Yun SH, Liem HA: The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart. J Pharmacol Exp Ther. 1990 Apr;253(1):13-9. - Pubmed Figueiredo A, Ribeiro CA, Goncalo M, Almeida L, Poiares-Baptista A, Teixeira F: Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. - Pubmed
DTHybrid score	1.1656
Muscarinic acetylcholine receptor M2
Name	Muscarinic acetylcholine receptor M2
Gene Name	CHRM2
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Ehlert FJ, Delen FM, Yun SH, Liem HA: The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart. J Pharmacol Exp Ther. 1990 Apr;253(1):13-9. - Pubmed Figueiredo A, Ribeiro CA, Goncalo M, Almeida L, Poiares-Baptista A, Teixeira F: Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. - Pubmed
DTHybrid score	0.9508
Muscarinic acetylcholine receptor M3
Name	Muscarinic acetylcholine receptor M3
Gene Name	CHRM3
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Ehlert FJ, Delen FM, Yun SH, Liem HA: The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart. J Pharmacol Exp Ther. 1990 Apr;253(1):13-9. - Pubmed Figueiredo A, Ribeiro CA, Goncalo M, Almeida L, Poiares-Baptista A, Teixeira F: Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. - Pubmed
DTHybrid score	0.9486
Muscarinic acetylcholine receptor M4
Name	Muscarinic acetylcholine receptor M4
Gene Name	CHRM4
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Ehlert FJ, Delen FM, Yun SH, Liem HA: The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart. J Pharmacol Exp Ther. 1990 Apr;253(1):13-9. - Pubmed Figueiredo A, Ribeiro CA, Goncalo M, Almeida L, Poiares-Baptista A, Teixeira F: Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. - Pubmed
DTHybrid score	0.7213
Muscarinic acetylcholine receptor M5
Name	Muscarinic acetylcholine receptor M5
Gene Name	CHRM5
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Ehlert FJ, Delen FM, Yun SH, Liem HA: The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart. J Pharmacol Exp Ther. 1990 Apr;253(1):13-9. - Pubmed Figueiredo A, Ribeiro CA, Goncalo M, Almeida L, Poiares-Baptista A, Teixeira F: Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. - Pubmed
DTHybrid score	0.626
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Stahl SM: Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr. 2008 Dec;13(12):1027-38. - Pubmed Richelson E, Nelson A: Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J Pharmacol Exp Ther. 1984 Jul;230(1):94-102. - Pubmed
DTHybrid score	1.0119
Alpha-1B adrenergic receptor
Name	Alpha-1B adrenergic receptor
Gene Name	ADRA1B
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Stahl SM: Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr. 2008 Dec;13(12):1027-38. - Pubmed Richelson E, Nelson A: Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J Pharmacol Exp Ther. 1984 Jul;230(1):94-102. - Pubmed
DTHybrid score	0.6762
Alpha-1D adrenergic receptor
Name	Alpha-1D adrenergic receptor
Gene Name	ADRA1D
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Stahl SM: Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr. 2008 Dec;13(12):1027-38. - Pubmed Richelson E, Nelson A: Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J Pharmacol Exp Ther. 1984 Jul;230(1):94-102. - Pubmed
DTHybrid score	0.4912
5-hydroxytryptamine 1A receptor
Name	5-hydroxytryptamine 1A receptor
Gene Name	HTR1A
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Maj J, Gancarczyk L, Gorszczyk L, Rawlow A: Doxepin as a blocker of central serotonin receptors. Pharmakopsychiatr Neuropsychopharmakol. 1977 Dec;10(6):318-24. - Pubmed
DTHybrid score	0.6048
Alpha-2A adrenergic receptor
Name	Alpha-2A adrenergic receptor
Gene Name	ADRA2A
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.8483
Alpha-2B adrenergic receptor
Name	Alpha-2B adrenergic receptor
Gene Name	ADRA2B
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.5639
Alpha-2C adrenergic receptor
Name	Alpha-2C adrenergic receptor
Gene Name	ADRA2C
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.544
D(2) dopamine receptor
Name	D(2) dopamine receptor
Gene Name	DRD2
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Richelson E, Nelson A: Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J Pharmacol Exp Ther. 1984 Jul;230(1):94-102. - Pubmed
DTHybrid score	0.7559

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Szewczuk-Boguslawska M, Kiejna A, Beszlej JA, Orzechowska-Juzwenko K, Milejski P: Doxepin inhibits CYP2D6 activity in vivo. Pol J Pharmacol. 2004 Jul-Aug;56(4):491-4. - Pubmed Grasmader K, Verwohlt PL, Rietschel M, Dragicevic A, Muller M, Hiemke C, Freymann N, Zobel A, Maier W, Rao ML: Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting. Eur J Clin Pharmacol. 2004 Jul;60(5):329-36. Epub 2004 May 28. - Pubmed Kirchheiner J, Meineke I, Muller G, Roots I, Brockmoller J: Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics. 2002 Oct;12(7):571-80. - Pubmed Haritos VS, Ghabrial H, Ahokas JT, Ching MS: Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin. Pharmacogenetics. 2000 Oct;10(7):591-603. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.1942
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Kirchheiner J, Meineke I, Muller G, Roots I, Brockmoller J: Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics. 2002 Oct;12(7):571-80. - Pubmed Hartter S, Tybring G, Friedberg T, Weigmann H, Hiemke C: The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res. 2002 Jul;19(7):1034-7. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6398
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Kirchheiner J, Meineke I, Muller G, Roots I, Brockmoller J: Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics. 2002 Oct;12(7):571-80. - Pubmed Hartter S, Tybring G, Friedberg T, Weigmann H, Hiemke C: The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res. 2002 Jul;19(7):1034-7. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6614
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Hartter S, Tybring G, Friedberg T, Weigmann H, Hiemke C: The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res. 2002 Jul;19(7):1034-7. - Pubmed Haritos VS, Ghabrial H, Ahokas JT, Ching MS: Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin. Pharmacogenetics. 2000 Oct;10(7):591-603. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7736
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Hartter S, Tybring G, Friedberg T, Weigmann H, Hiemke C: The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res. 2002 Jul;19(7):1034-7. - Pubmed
DTHybrid score	1.1868

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score	0.7732

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.7732

Id	Partner name	Gene Name	Score
23	D(1A) dopamine receptor	DRD1	0.5434
4118	Cytochrome P450 3A5	CYP3A5	0.3618
638	D(3) dopamine receptor	DRD3	0.3493
713	Sodium-dependent dopamine transporter	SLC6A3	0.3448
432	D(4) dopamine receptor	DRD4	0.3381
4924	Cytochrome P450 2C8	CYP2C8	0.3336
6030	Cytochrome P450 2B6	CYP2B6	0.3015
885	5-hydroxytryptamine 1B receptor	HTR1B	0.3003
725	5-hydroxytryptamine 1D receptor	HTR1D	0.2973
6013	Cytochrome P450 2E1	CYP2E1	0.2864
163	D(1B) dopamine receptor	DRD5	0.2645
6107	Cytochrome P450 3A7	CYP3A7	0.2572
716	5-hydroxytryptamine 7 receptor	HTR7	0.2374
587	Serum albumin	ALB	0.2253
6145	Solute carrier family 22 member 1	SLC22A1	0.2073
766	Beta-2 adrenergic receptor	ADRB2	0.1888
193	Beta-1 adrenergic receptor	ADRB1	0.1833
6024	Cytochrome P450 1A1	CYP1A1	0.1769
6144	Solute carrier family 22 member 2	SLC22A2	0.1707
3923	Cholinesterase	BCHE	0.1659
3941	Amine oxidase [flavin-containing] A	MAOA	0.1615
1256	5-hydroxytryptamine 6 receptor	HTR6	0.1473
5718	Cytochrome P450 2A6	CYP2A6	0.1417
131	Synaptic vesicular amine transporter	SLC18A2	0.134
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1197
341	5-hydroxytryptamine 3 receptor	HTR3A	0.1179
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.1153
118	Organic cation/carnitine transporter 2	SLC22A5	0.1081
20	Prostaglandin G/H synthase 1	PTGS1	0.1075
6147	Solute carrier family 22 member 3	SLC22A3	0.1043
528	5-hydroxytryptamine 1E receptor	HTR1E	0.1004
3939	Amine oxidase [flavin-containing] B	MAOB	0.0935
6106	Cytochrome P450 2C18	CYP2C18	0.0919
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0871
465	Calmodulin	CALM1	0.08
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.078
1517	Beta-3 adrenergic receptor	ADRB3	0.0762
833	Organic cation/carnitine transporter 1	SLC22A4	0.0729
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0648
94	5-hydroxytryptamine 4 receptor	HTR4	0.0638
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0631
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0624
862	Multidrug resistance-associated protein 1	ABCC1	0.06
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.06
696	Kappa-type opioid receptor	OPRK1	0.0589
1656	CYP2B protein	CYP2B	0.0568
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0562
1729	Solute carrier family 22 member 6	SLC22A6	0.0541
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0537
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0537
6432	Transporter	snf	0.053
6142	Solute carrier family 22 member 8	SLC22A8	0.0527
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0514
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0514
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0512
828	Phenylalanine-4-hydroxylase	PAH	0.0509
3109	Phenylalanine-4-hydroxylase	phhA	0.0509
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0506
467	Delta-type opioid receptor	OPRD1	0.0502
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.05
847	Mu-type opioid receptor	OPRM1	0.0493
1898	Cytochrome P450 1B1	CYP1B1	0.0492
290	Prostaglandin G/H synthase 2	PTGS2	0.0491
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0482
474	Acetylcholinesterase	ACHE	0.0481
3811	Cytochrome P450 19A1	CYP19A1	0.0478
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0474
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0465
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0432
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0422
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0422
6070	Nischarin	NISCH	0.0421
776	Bile salt export pump	ABCB11	0.042
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0412
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0406
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0399
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0389
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0384
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0369
1636	Trace amine-associated receptor 1	TAAR1	0.0365
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0359
731	HIV-1 protease	HIV-1 protease	0.0351
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0349
6182	Cytochrome P450 2J2	CYP2J2	0.0349
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0346
164	Histamine H4 receptor	HRH4	0.0335
2129	Sucrase-isomaltase, intestinal	SI	0.0331
136	Estrogen receptor	ESR1	0.0326
1341	Histamine H3 receptor	HRH3	0.0319
6020	Aldehyde oxidase	AOX1	0.0316
871	Glucocorticoid receptor	NR3C1	0.0316
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0311
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0304
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0303
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.03
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0297
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0296
2164	Multidrug resistance-associated protein 4	ABCC4	0.0285
817	DNA topoisomerase 2-alpha	TOP2A	0.0284
6138	Multidrug resistance protein 3	ABCB4	0.0272
260	Cytochrome P450 51	ERG11	0.0272
761	Cytochrome P450 51	ERG11	0.0272
3163	Cytochrome P450 51	cyp51	0.0272
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0269
6143	Solute carrier family 22 member 7	SLC22A7	0.0267
174	Sigma 1-type opioid receptor	SIGMAR1	0.0263
36	Insulin receptor	INSR	0.0258
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0257
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0253
1618	High affinity nerve growth factor receptor	NTRK1	0.0249
844	Epidermal growth factor receptor	EGFR	0.0246
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0243
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0239
380	Cytochrome P450 17A1	CYP17A1	0.0237
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0227
571	Melatonin receptor type 1A	MTNR1A	0.0225
362	Melatonin receptor type 1B	MTNR1B	0.0225
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0225
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0214
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0214
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0213
122	P2Y purinoceptor 12	P2RY12	0.021
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0207
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0206
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0199
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0195
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0195
1757	Myeloperoxidase	MPO	0.0191
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0189
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0188
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0187
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0184
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0183
4120	NADPH--cytochrome P450 reductase	POR	0.0181
477	DNA topoisomerase 4 subunit A	parC	0.0181
886	DNA topoisomerase 4 subunit A	parC	0.0181
6226	DNA topoisomerase 4 subunit A	parC	0.0181
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0181
904	Glutathione S-transferase P	GSTP1	0.0181
468	Cytochrome P450 4A11	CYP4A11	0.018
404	DNA gyrase subunit A	gyrA	0.0178
6224	DNA gyrase subunit A	gyrA	0.0178
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0176
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0176
6151	Monocarboxylate transporter 10	SLC16A10	0.0175
6031	Cytochrome P450 3A43	CYP3A43	0.0172
233	Potassium channel subfamily K member 2	KCNK2	0.017
3810	Catechol O-methyltransferase	COMT	0.0169
4203	Histamine N-methyltransferase	HNMT	0.0169
516	Neurotensin receptor type 2	NTSR2	0.0168
1024	Solute carrier family 22 member 11	SLC22A11	0.0167
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0165
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0165
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0165
70	Type-1 angiotensin II receptor	AGTR1	0.0162
723	Cytosolic phospholipase A2	PLA2G4A	0.0162
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0161
146	Androgen receptor	AR	0.016
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.016
921	Glutamate receptor 2	GRIA2	0.0158
891	Dihydropteroate synthase	folP	0.0157
5359	Dihydropteroate synthase	folP	0.0157
7175	Dihydropteroate synthase	sulI	0.0157
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0156
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0155
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0152
923	Glutamate receptor 3	GRIA3	0.0149
777	Tumor necrosis factor	TNF	0.0148
3947	Xanthine dehydrogenase/oxidase	XDH	0.0148
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0146
504	Mast/stem cell growth factor receptor	KIT	0.0146
3426	Glutamine synthetase	glnA	0.0145
3987	Glutamine synthetase	GLUL	0.0145
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0145
614	Progesterone receptor	PGR	0.0145
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0144
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0144
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0143
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0142
6148	Multidrug resistance-associated protein 7	ABCC10	0.014
4604	Liver carboxylesterase 1	CES1	0.014
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0139
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0139
1275	Estrogen sulfotransferase	SULT1E1	0.0138
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0132
183	Vascular endothelial growth factor A	VEGFA	0.013
6137	Multidrug resistance-associated protein 6	ABCC6	0.0129
6141	Sodium/bile acid cotransporter	SLC10A1	0.0129
818	50S ribosomal protein L10	rplJ	0.0128
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0127
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0126
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0126
6220	Aryl hydrocarbon receptor	AHR	0.0126
161	Tubulin beta chain	TUBB	0.0125
312	Tubulin beta chain	TUB2	0.0125
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0125
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0123
427	Substance-P receptor	TACR1	0.0118
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0117
407	Vascular endothelial growth factor receptor 2	KDR	0.0117
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0115
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0115
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0113
869	Estrogen receptor beta	ESR2	0.0111
6136	Multidrug resistance-associated protein 5	ABCC5	0.0111
26	Vascular endothelial growth factor receptor 3	FLT4	0.0108
1178	Adenosine A2a receptor	ADORA2A	0.0106
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0106
756	Sex hormone-binding globulin	SHBG	0.0104
32	Vascular endothelial growth factor receptor 1	FLT1	0.0104
6014	Cytochrome P450 2A13	CYP2A13	0.0103
232	Corticosteroid-binding globulin	SERPINA6	0.0103
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0103
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0103
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0103
952	Dipeptidyl peptidase 4	DPP4	0.0103
482	Glycine receptor subunit alpha-1	GLRA1	0.0102
16	Adenosine A1 receptor	ADORA1	0.0102
6859	Protein S100-A4	S100A4	0.0101
373	Transthyretin	TTR	0.01
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.01
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0099
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0099
1050	Bile salt sulfotransferase	SULT2A1	0.0098
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
592	Carbonic anhydrase 4	CA4	0.0097
811	Translocator protein	TSPO	0.0096
49	Endothelin B receptor	EDNRB	0.0096
365	Dihydrofolate reductase	DHFR	0.0094
2381	Dihydrofolate reductase	DFR1	0.0094
2833	Dihydrofolate reductase	Not Available	0.0094
2931	Dihydrofolate reductase	folA	0.0094
3544	Dihydrofolate reductase	folA	0.0094
3682	Dihydrofolate reductase	folA	0.0094
6642	Dihydrofolate reductase	folA	0.0094
6756	Dihydrofolate reductase	dfrA	0.0094
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0093
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0093
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0093
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0093
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0092
6102	Arylamine N-acetyltransferase 2	NAT2	0.0092
1192	Sulfotransferase 1A1	SULT1A1	0.0092
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0092
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0091
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.009
295	Carbonic anhydrase 1	CA1	0.0089
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0089
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0089
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0089
738	Monocarboxylate transporter 1	SLC16A1	0.0089
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0088
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0087
1010	Cytochrome P450 51A1	CYP51A1	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0086
768	FK506-binding protein 1A	FKBP1A	0.0085
319	Opioid receptor, sigma 1	OPRS1	0.0082
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
5787	Angiopoietin-1 receptor	TEK	0.008
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0079
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0079
173	Toll-like receptor 7	TLR7	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0078
29	Tubulin beta-1 chain	TUBB1	0.0077
244	Angiotensin-converting enzyme	ACE	0.0076
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0076
2449	Tubulin alpha-3 chain	TUBA1A	0.0076
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0076
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0076
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0075
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0075
4122	Histone deacetylase 2	HDAC2	0.0075
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0074
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0074
4237	50S ribosomal protein L22	rplV	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0072
357	Carbonic anhydrase 2	CA2	0.0072
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0071
737	Mineralocorticoid receptor	NR3C2	0.0071
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.007
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0068
68	Cannabinoid receptor 1	CNR1	0.0068
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0068
1629	Transcription factor AP-1	JUN	0.0067
273	Apoptosis regulator Bcl-2	BCL2	0.0067
2499	Tubulin beta-2C chain	TUBB2C	0.0065
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
275	Arachidonate 5-lipoxygenase	ALOX5	0.0063
1353	DNA topoisomerase 1	TOP1	0.0063
3552	DNA topoisomerase 1	topA	0.0063
133	Dihydropterate synthase	sulI	0.0063
2112	Toll-like receptor 9	TLR9	0.0062
6085	Fatty acid-binding protein, intestinal	FABP2	0.0062
6097	Protein S100-A2	S100A2	0.006
1810	Protein S100-A1	S100A1	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
6126	Carbonic anhydrase 7	CA7	0.006
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0059
2539	Tubulin alpha-1 chain	TUBA4A	0.0059
284	DNA-directed RNA polymerase beta chain	rpoB	0.0059
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0059
814	Ryanodine receptor 1	RYR1	0.0059
153	Dopamine beta-hydroxylase	DBH	0.0059
24	Thymidylate synthase	TMP1	0.0058
359	Thymidylate synthase	TYMS	0.0058
2626	Thymidylate synthase	thyA	0.0058
2729	Thymidylate synthase	thyA	0.0058
5352	Thymidylate synthase	THYA	0.0058
4238	50S ribosomal protein L4	rplD	0.0058
5578	50S ribosomal protein L4	rplD	0.0058
6173	50S ribosomal protein L4	rplD	0.0058
6219	50S ribosomal protein L4	rplD	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0058
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0058
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
4103	Proteasome subunit beta type 2	PSMB2	0.0057
4102	Proteasome subunit beta type 5	PSMB5	0.0056
4101	Proteasome subunit beta type 1	PSMB1	0.0056
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0056
823	Fibroblast growth factor receptor 2	FGFR2	0.0055
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0055
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0055
6506	Stathmin-4	STMN4	0.0055
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0054
239	Coagulation factor X	F10	0.0054
6044	Serum paraoxonase/lactonase 3	PON3	0.0054
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
518	Peroxidase/catalase T	katG	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
6043	Putative G-protein coupled receptor 44	GPR44	0.0053
856	Vitamin D3 receptor	VDR	0.0053
1864	RET proto-oncogene	RET	0.0053
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0052
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0052
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0052
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0052
712	Tubulin alpha chain	TUB1	0.0052
1048	Protein S100-A13	S100A13	0.0052
2226	Protein S100-A12	S100A12	0.0052
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0052
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0051
694	Matrix protein 2	M	0.0051
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0051
780	Retinoic acid receptor RXR-gamma	RXRG	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
1374	Natriuretic peptides B	NPPB	0.005
1827	Gap junction alpha-1 protein	GJA1	0.005
1908	Vascular cell adhesion protein 1	VCAM1	0.005
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0049
2132	Protein S100-B	S100B	0.0049
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0049
563	Thyroid peroxidase	TPO	0.0048
54	Prothrombin	F2	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0048
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
5300	Antigen peptide transporter 1	TAP1	0.0047
4311	tRNA	TRDMT1	0.0047
4325	tRNA	trmD	0.0047
4328	tRNA	trmD	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1852	Microtubule-associated protein 2	MAP2	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
88	Retinoic acid receptor RXR-beta	RXRB	0.0046
634	Squalene monooxygenase	SQLE	0.0046
7196	Squalene monooxygenase	ERG1	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0045
165	FL cytokine receptor	FLT3	0.0045
130	Prostacyclin synthase	PTGIS	0.0044
6146	High affinity copper uptake protein 1	SLC31A1	0.0044
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0043
117	Sterol O-acyltransferase 1	SOAT1	0.0043
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0043
705	Glutamate receptor 1	GRIA1	0.0043
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0042
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0042
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
3957	Adenosine deaminase	ADA	0.0042
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0042
1648	Elastin	ELN	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
751	Potassium channel subfamily K member 6	KCNK6	0.0041
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
106	Cannabinoid receptor 2	CNR2	0.004
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
976	Platelet glycoprotein IX	GP9	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
6174	50S ribosomal protein L32	rpmF	0.004
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.004
6149	Solute carrier family 22 member 10	SLC22A10	0.004
581	Cytochrome P450 2R1	CYP2R1	0.0039
3856	Fibroblast growth factor receptor 3	FGFR3	0.0039
1541	Metalloproteinase	mmp20	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
85	Growth hormone receptor	GHR	0.0038
172	Potassium channel subfamily K member 1	KCNK1	0.0037
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
33	Cystine/glutamate transporter	SLC7A11	0.0037
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0036
3932	Glutathione S-transferase A2	GSTA2	0.0036
4773	Deoxycytidine kinase	DCK	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0035
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0035
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
558	Solute carrier family 12 member 1	SLC12A1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0033
65	Matrix metalloproteinase-9	Not Available	0.0033
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0033
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
1630	Integrin beta-2	ITGB2	0.0032
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0032
7	Nitric oxide synthase, inducible	NOS2	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
6824	Tyrosine-protein kinase Lyn	LYN	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
936	Ephrin type-A receptor 2	EPHA2	0.003
3809	Estrogen-related receptor gamma	ESRRG	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
1196	Complement decay-accelerating factor	CD55	0.0029
469	Annexin A1	ANXA1	0.0029
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0029
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0029
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0029
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1992	Vitamin D-binding protein	GC	0.0028
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0027
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0027
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0027
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0027
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0027
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0027
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0027
5934	Cytochrome P450 26A1	CYP26A1	0.0026
84	Nuclear receptor 0B1	NR0B1	0.0026
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0026
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0026
4192	DNA topoisomerase 2-beta	TOP2B	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
2808	Chloramphenicol acetyltransferase 3	cat3	0.0026
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0025
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
3830	Calreticulin	CALR	0.0025
4217	Telomerase reverse transcriptase	TERT	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
444	Alcohol dehydrogenase 1B	ADH1B	0.0025
572	Integrin alpha-L	ITGAL	0.0025
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0025
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0024
3937	Fatty-acid amide hydrolase	FAAH	0.0024
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
908	Glutathione S-transferase theta-1	GSTT1	0.0024
251	Alcohol dehydrogenase 1A	ADH1A	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3808	Dihydropteroate synthase 2	folP2	0.0023
3601	Dihydropteroate synthase 1	folP1	0.0023
3807	Dihydropteroate synthase 1	folP1	0.0023
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
3086	Plasmepsin-2	Not Available	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
2417	Chloramphenicol acetyltransferase	cat	0.0023
3278	Chloramphenicol acetyltransferase	cat	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
5923	Microtubule-associated protein tau	MAPT	0.0023
5924	Microtubule-associated protein 4	MAP4	0.0023
2810	Dr hemagglutinin structural subunit	draA	0.0023
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0023
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0023
820	Glycine receptor subunit alpha-2	GLRA2	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
162	Retinoic acid receptor gamma-1	RARG	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
268	Adenosine A2b receptor	ADORA2B	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
6048	Troponin C, skeletal muscle	TNNC2	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
517	Alcohol dehydrogenase 1C	ADH1C	0.002
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.002
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.002
291	Nitric-oxide synthase, endothelial	NOS3	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
5798	Mitogen-activated protein kinase 11	MAPK11	0.002
2320	Thymidine kinase, cytosolic	TK1	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0019
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0018
896	Glutathione S-transferase Mu 1	GSTM1	0.0018
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0018
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0018
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
1039	Histone deacetylase 9	HDAC9	0.0018
2021	Thrombomodulin	THBD	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
6218	Pannexin-1	PANX1	0.0017
484	Tyrosine-protein kinase ABL2	ABL2	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
2216	Fibroblast growth factor receptor 4	FGFR4	0.0016
1243	Cathepsin D	CTSD	0.0016
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0016
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0015
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
489	Monocarboxylate transporter 2	SLC16A7	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
267	Plasminogen activator inhibitor 1	SERPINE1	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
4226	Uridine phosphorylase 2	UPP2	0.0014
6163	Copper-transporting ATPase 2	ATP7B	0.0013
6165	Copper-transporting ATPase 1	ATP7A	0.0013
2207	Rhodopsin	RHO	0.0013
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
6221	Steroid hormone receptor ERR1	ESRRA	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
4225	Uridine phosphorylase 1	UPP1	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
6042	Prostaglandin reductase 2	PTGR2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
413	Amidophosphoribosyltransferase	PPAT	0.0012
2515	Amidophosphoribosyltransferase	purF	0.0012
3714	Amidophosphoribosyltransferase	purF	0.0012
1792	Tissue-type plasminogen activator	PLAT	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
6459	Glycodelin	PAEP	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
3221	Cytochrome c4	cc4	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
1313	Lactoylglutathione lyase	GLO1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
719	Retinoic acid receptor responder protein 1	RARRES1	0.0009
770	Retinoic acid-induced protein 3	GPRC5A	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
569	Retinal dehydrogenase 2	ALDH1A2	0.0008
1867	Major prion protein	PRNP	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
611	Retinal dehydrogenase 1	ALDH1A1	0.0008
1025	Aquaporin-1	AQP1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
2298	Cytochrome P450-cam	camC	0.0007
76	Nitric-oxide synthase, brain	NOS1	0.0007
822	Aldose reductase	AKR1B1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1507	Cytochrome c	CYCS	0.0005
798	Osteocalcin	BGLAP	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1650	Heme carrier protein 1	SLC46A1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01142 - Doxepin

Targets

Enzymes

Transporters

Carriers

Predictions