DT-Web

DB00397 - Phenylpropanolamine


Identification
Name Phenylpropanolamine
Accession Number DB00397 (APRD00457)
Type small molecule
Description Phenylpropanolamine has been withdrawn in Canada. In November 2000, the Food and Drug Administration (FDA) issued a public health advisory against the use of the drug.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 151.2056
Groups approved
Monoisotopic Weight 151.099714043
Pharmacology
Indication For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
Mechanism of action Phenylpropanolamine acts directly on alpha- and, to a lesser degree, beta-adrenergic receptors in the mucosa of the respiratory tract. Stimulation of alpha-adrenergic receptors produces vasoconstriction, reduces tissue hyperemia, edema, and nasal congestion, and increases nasal airway patency. PPA indirectly stimulates beta-receptors, producing tachycardia and a positive inotropic effect.
Absorption Reduced bioavailability (about 38%) from gastrointestinal tract because of first pass metabolism by monoamine oxidase in the stomach and liver.
Protein binding Not Available
Biotransformation Hepatic
Route of elimination Not Available
Toxicity May induce ventricular extrasystoles and short paroxysms of ventricular tachycardia, a sensation of fullness in the head and tingling of the extremities; LD50=1490mg/kg (orally in rat)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetophenazine Decreased anorexic effect, may increase psychotic symptoms
Alseroxylon Increased arterial pressure
Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of phenylpropanolamine.
Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of phenylpropanolamine.
Bromocriptine The sympathomimetic, phenylpropanolamine, increases the toxicity of bromocriptine.
Chlorpromazine Decreased anorexic effect, may increase psychotic symptoms
Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of phenylpropanolamine.
Deserpidine Increased arterial pressure
Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of phenylpropanolamine.
Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of phenylpropanolamine.
Ethopropazine Decreased anorexic effect, may increase psychotic symptoms
Fluoxetine Risk of serotoninergic syndrome
Fluphenazine Decreased anorexic effect, may increase psychotic symptoms
Fluvoxamine Risk of serotoninergic syndrome
Guanethidine Phenylpropanolamine may decrease the effect of guanethidine.
Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of phenylpropanolamine.
Iobenguane Sympathomimetic that increase chances of producing a false negative imaging result
Isocarboxazid Increased arterial pressure
Linezolid Possible increase of arterial pressure
Mesoridazine Decreased anorexic effect, may increase psychotic symptoms
Methdilazine Decreased anorexic effect, may increase psychotic symptoms
Methotrimeprazine Decreased anorexic effect, may increase psychotic symptoms
Methyldopa Increased arterial pressure
Midodrine Increased arterial pressure
Moclobemide Moclobemide increases the sympathomimetic effect of phenylpropanolamine.
Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of phenylpropanolamine.
Pargyline Increased arterial pressure
Paroxetine Risk of serotoninergic syndrome
Perphenazine Decreased anorexic effect, may increase psychotic symptoms
Phenelzine Increased arterial pressure
Prochlorperazine Decreased anorexic effect, may increase psychotic symptoms.
Promazine Decreased anorexic effect, may increase psychotic symptoms
Promethazine Decreased anorexic effect, may increase psychotic symptoms.
Propericiazine Decreased anorexic effect, may increase psychotic symptoms.
Propiomazine Decreased anorexic effect, may increase psychotic symptoms
Protriptyline The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of phenylpropanolamine.
Rasagiline Increased arterial pressure
Reserpine Increased arterial pressure
Thiethylperazine Decreased anorexic effect, may increase psychotic symptoms
Thioridazine Decreased anorexic effect, may increase psychotic symptoms
Tranylcypromine Increased arterial pressure
Trifluoperazine Decreased anorexic effect, may increase psychotic symptoms
Triflupromazine Decreased anorexic effect, may increase psychotic symptoms
Trimeprazine Decreased anorexic effect, may increase psychotic symptoms
Trimipramine The tricyclic antidepressant, trimipramine, increases the sympathomimetic effect of phenylpropanolamine.
Venlafaxine Risk of serotoninergic syndrome
Food Interactions
  • Take without regard to meals.
  • Limit caffeine intake.

Targets


Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions agonist
References
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Wellman PJ, McMahon LR, Green T, Tole A: Effects of the alpha 1a-adrenoceptor antagonist RS-17053 on phenylpropanolamine-induced anorexia in rats. Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):281-4. - Pubmed
  • Buckner SA, Milicic I, Daza AV, Meyer MD, Altenbach RJ, Williams M, Sullivan JP, Brioni JD: ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes. Eur J Pharmacol. 2002 Aug 2;449(1-2):159-65. - Pubmed
  • Altenbach RJ, Khilevich A, Kolasa T, Rohde JJ, Bhatia PA, Patel MV, Searle XB, Yang F, Bunnelle WH, Tietje K, Bayburt EK, Carroll WA, Meyer MD, Henry R, Buckner SA, Kuk J, Daza AV, Milicic IV, Cain JC, Kang CH, Ireland LM, Carr TL, Miller TR, Hancock AA, Nakane M, Esbenshade TA, Brune ME, O'Neill AB, Gauvin DM, Katwala SP, Holladay MW, Brioni JD, Sullivan JP: Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonami de, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem. 2004 Jun 3;47(12):3220-35. - Pubmed
  • Moya-Huff FA, Maher TJ: Adrenergic receptor subtype activation by (+)-, (-)- and (+/-)-norephedrine in the pithed rat. J Pharm Pharmacol. 1987 Feb;39(2):108-12. - Pubmed
DTHybrid score 0.4491
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Flavahan NA: Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors. J Pharmacol Exp Ther. 2005 Apr;313(1):432-9. Epub 2004 Dec 17. - Pubmed
DTHybrid score 0.4057
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions partial agonist
References
  • Cheng JT, Kuo DY: Both alpha1-adrenergic and D(1)-dopaminergic neurotransmissions are involved in phenylpropanolamine-mediated feeding suppression in mice. Neurosci Lett. 2003 Aug 21;347(2):136-8. - Pubmed
DTHybrid score 0.267
Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action unknown
Actions agonist
References
  • Thomas SH, Clark KL, Allen R, Smith SE: A comparison of the cardiovascular effects of phenylpropanolamine and phenylephrine containing proprietary cold remedies. Br J Clin Pharmacol. 1991 Dec;32(6):705-11. - Pubmed
  • Moya-Huff FA, Maher TJ: Adrenergic receptor subtype activation by (+)-, (-)- and (+/-)-norephedrine in the pithed rat. J Pharm Pharmacol. 1987 Feb;39(2):108-12. - Pubmed
DTHybrid score 0.5221

Enzymes


Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Actions inhibitor
References
  • -
  • Yu PH: Inhibition of monoamine oxidase activity by phenylpropanolamine, an anorectic agent. Res Commun Chem Pathol Pharmacol. 1986 Feb;51(2):163-71. - Pubmed
DTHybrid score 0.4339
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3241

Predictions


Id Partner name Gene Name Score
766 Beta-2 adrenergic receptor ADRB2 0.281
4119 Cytochrome P450 2D6 CYP2D6 0.2233
3939 Amine oxidase [flavin-containing] B MAOB 0.1876
831 D(2) dopamine receptor DRD2 0.174
4512 Cytochrome P450 3A4 CYP3A4 0.172
632 Alpha-1B adrenergic receptor ADRA1B 0.162
502 5-hydroxytryptamine 2A receptor HTR2A 0.147
629 Alpha-2B adrenergic receptor ADRA2B 0.1304
320 5-hydroxytryptamine 1A receptor HTR1A 0.1282
378 Alpha-2C adrenergic receptor ADRA2C 0.1237
1588 Multidrug resistance protein 1 ABCB1 0.1206
6016 Cytochrome P450 2C19 CYP2C19 0.0949
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0939
885 5-hydroxytryptamine 1B receptor HTR1B 0.0937
789 Alpha-1D adrenergic receptor ADRA1D 0.0908
590 5-hydroxytryptamine 2C receptor HTR2C 0.0869
4757 Cytochrome P450 2C9 CYP2C9 0.0864
824 Sodium-dependent serotonin transporter SLC6A4 0.0861
1517 Beta-3 adrenergic receptor ADRB3 0.0856
725 5-hydroxytryptamine 1D receptor HTR1D 0.0837
163 D(1B) dopamine receptor DRD5 0.0815
432 D(4) dopamine receptor DRD4 0.0795
492 Histamine H1 receptor HRH1 0.0735
713 Sodium-dependent dopamine transporter SLC6A3 0.0734
638 D(3) dopamine receptor DRD3 0.0689
6013 Cytochrome P450 2E1 CYP2E1 0.0623
6024 Cytochrome P450 1A1 CYP1A1 0.0594
131 Synaptic vesicular amine transporter SLC18A2 0.057
6145 Solute carrier family 22 member 1 SLC22A1 0.0511
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0498
436 5-hydroxytryptamine 2B receptor HTR2B 0.0496
4118 Cytochrome P450 3A5 CYP3A5 0.049
6030 Cytochrome P450 2B6 CYP2B6 0.0483
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0433
4924 Cytochrome P450 2C8 CYP2C8 0.043
6107 Cytochrome P450 3A7 CYP3A7 0.0382
6144 Solute carrier family 22 member 2 SLC22A2 0.0382
716 5-hydroxytryptamine 7 receptor HTR7 0.0371
3810 Catechol O-methyltransferase COMT 0.0362
511 5-hydroxytryptamine 1F receptor HTR1F 0.0362
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0343
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0342
587 Serum albumin ALB 0.0334
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0334
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0324
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0298
5718 Cytochrome P450 2A6 CYP2A6 0.0265
36 Insulin receptor INSR 0.0258
6147 Solute carrier family 22 member 3 SLC22A3 0.0257
1256 5-hydroxytryptamine 6 receptor HTR6 0.0256
118 Organic cation/carnitine transporter 2 SLC22A5 0.0248
3923 Cholinesterase BCHE 0.0211
828 Phenylalanine-4-hydroxylase PAH 0.0193
3109 Phenylalanine-4-hydroxylase phhA 0.0193
341 5-hydroxytryptamine 3 receptor HTR3A 0.0191
465 Calmodulin CALM1 0.0191
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0185
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0178
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0175
3811 Cytochrome P450 19A1 CYP19A1 0.0174
20 Prostaglandin G/H synthase 1 PTGS1 0.0156
528 5-hydroxytryptamine 1E receptor HTR1E 0.0148
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0144
3426 Glutamine synthetase glnA 0.014
3987 Glutamine synthetase GLUL 0.014
124 Histamine H2 receptor HRH2 0.013
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0125
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
6106 Cytochrome P450 2C18 CYP2C18 0.0123
3076 Antigen 85-C fbpC 0.0122
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0121
1729 Solute carrier family 22 member 6 SLC22A6 0.0119
1898 Cytochrome P450 1B1 CYP1B1 0.0116
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0113
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0111
1636 Trace amine-associated receptor 1 TAAR1 0.0107
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0107
1820 Beta-nerve growth factor NGF 0.0105
5698 Riboflavin synthase alpha chain ribE 0.0105
777 Tumor necrosis factor TNF 0.0102
408 Riboflavin kinase RFK 0.0101
474 Acetylcholinesterase ACHE 0.0101
833 Organic cation/carnitine transporter 1 SLC22A4 0.0101
6070 Nischarin NISCH 0.0099
146 Androgen receptor AR 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
817 DNA topoisomerase 2-alpha TOP2A 0.0096
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0095
1656 CYP2B protein CYP2B 0.0093
6847 Lactase-phlorizin hydrolase LCT 0.0093
1757 Myeloperoxidase MPO 0.0093
6020 Aldehyde oxidase AOX1 0.0093
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0091
290 Prostaglandin G/H synthase 2 PTGS2 0.009
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0084
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0084
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
3947 Xanthine dehydrogenase/oxidase XDH 0.0082
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0082
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0082
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0082
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0077
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0077
4120 NADPH--cytochrome P450 reductase POR 0.0077
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0076
3917 Methylenetetrahydrofolate reductase MTHFR 0.0075
654 Flavin reductase BLVRB 0.0075
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0072
6151 Monocarboxylate transporter 10 SLC16A10 0.0071
6014 Cytochrome P450 2A13 CYP2A13 0.007
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0068
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0066
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0066
16 Adenosine A1 receptor ADORA1 0.0066
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0065
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0065
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0064
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0062
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0062
198 Sodium channel protein type 10 subunit alpha SCN10A 0.006
1374 Natriuretic peptides B NPPB 0.0058
1827 Gap junction alpha-1 protein GJA1 0.0058
1908 Vascular cell adhesion protein 1 VCAM1 0.0058
6031 Cytochrome P450 3A43 CYP3A43 0.0057
862 Multidrug resistance-associated protein 1 ABCC1 0.0055
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0055
233 Potassium channel subfamily K member 2 KCNK2 0.0054
776 Bile salt export pump ABCB11 0.0054
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0053
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0053
1178 Adenosine A2a receptor ADORA2A 0.0053
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0053
6143 Solute carrier family 22 member 7 SLC22A7 0.0052
2300 Lysozyme E 0.0052
3633 Lysozyme R 0.0052
5597 Lysozyme 17 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
153 Dopamine beta-hydroxylase DBH 0.005
136 Estrogen receptor ESR1 0.0049
6859 Protein S100-A4 S100A4 0.0048
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0048
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0048
714 Glutathione reductase, mitochondrial GSR 0.0047
6432 Transporter snf 0.0046
6220 Aryl hydrocarbon receptor AHR 0.0045
696 Kappa-type opioid receptor OPRK1 0.0044
183 Vascular endothelial growth factor A VEGFA 0.0044
1176 Mitogen-activated protein kinase 1 MAPK1 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
6142 Solute carrier family 22 member 8 SLC22A8 0.0042
3913 Glutamic acid decarboxylase GAD65 0.0042
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
1483 Membrane copper amine oxidase AOC3 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0037
1360 Sphingomyelin phosphodiesterase SMPD1 0.0036
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0035
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0034
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0034
273 Apoptosis regulator Bcl-2 BCL2 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0034
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0033
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0033
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0033
468 Cytochrome P450 4A11 CYP4A11 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0032
2164 Multidrug resistance-associated protein 4 ABCC4 0.0031
164 Histamine H4 receptor HRH4 0.0031
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0031
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0031
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0031
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0031
818 50S ribosomal protein L10 rplJ 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
173 Toll-like receptor 7 TLR7 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0029
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0029
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0028
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0027
756 Sex hormone-binding globulin SHBG 0.0027
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0027
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0027
1618 High affinity nerve growth factor receptor NTRK1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0026
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0025
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0024
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0024
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0024
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0024
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0023
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
3957 Adenosine deaminase ADA 0.0023
6148 Multidrug resistance-associated protein 7 ABCC10 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0023
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0023
467 Delta-type opioid receptor OPRD1 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
731 HIV-1 protease HIV-1 protease 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0021
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0021
260 Cytochrome P450 51 ERG11 0.0021
761 Cytochrome P450 51 ERG11 0.0021
3163 Cytochrome P450 51 cyp51 0.0021
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
869 Estrogen receptor beta ESR2 0.0021
6141 Sodium/bile acid cotransporter SLC10A1 0.0021
871 Glucocorticoid receptor NR3C1 0.0021
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.002
6133 Sodium channel subunit beta-2 SCN2B 0.002
6134 Sodium channel subunit beta-3 SCN3B 0.002
6132 Sodium channel subunit beta-1 SCN1B 0.002
6135 Sodium channel subunit beta-4 SCN4B 0.002
6127 Carbonic anhydrase-related protein CA8 0.002
6129 Carbonic anhydrase-related protein 11 CA11 0.002
6128 Carbonic anhydrase-related protein 10 CA10 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.002
228 Beta platelet-derived growth factor receptor PDGFRB 0.0019
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0018
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
6130 Carbonic anhydrase 13 CA13 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
504 Mast/stem cell growth factor receptor KIT 0.0018
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0018
1648 Elastin ELN 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0017
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
6131 Carbonic anhydrase 14 CA14 0.0017
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
1243 Cathepsin D CTSD 0.0016
1010 Cytochrome P450 51A1 CYP51A1 0.0016
373 Transthyretin TTR 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
427 Substance-P receptor TACR1 0.0016
6122 Carbonic anhydrase 3 CA3 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
921 Glutamate receptor 2 GRIA2 0.0015
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0015
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0015
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0015
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0014
295 Carbonic anhydrase 1 CA1 0.0014
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
847 Mu-type opioid receptor OPRM1 0.0014
6126 Carbonic anhydrase 7 CA7 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0013
380 Cytochrome P450 17A1 CYP17A1 0.0013
844 Epidermal growth factor receptor EGFR 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
1024 Solute carrier family 22 member 11 SLC22A11 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0012
518 Peroxidase/catalase T katG 0.0012
1629 Transcription factor AP-1 JUN 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
563 Thyroid peroxidase TPO 0.0011
4192 DNA topoisomerase 2-beta TOP2B 0.0011
592 Carbonic anhydrase 4 CA4 0.0011
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0011
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
239 Coagulation factor X F10 0.001
4237 50S ribosomal protein L22 rplV 0.001
6136 Multidrug resistance-associated protein 5 ABCC5 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.001
4604 Liver carboxylesterase 1 CES1 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.001
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
823 Fibroblast growth factor receptor 2 FGFR2 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
6137 Multidrug resistance-associated protein 6 ABCC6 0.0009
6182 Cytochrome P450 2J2 CYP2J2 0.0009
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
365 Dihydrofolate reductase DHFR 0.0009
2381 Dihydrofolate reductase DFR1 0.0009
2833 Dihydrofolate reductase Not Available 0.0009
2931 Dihydrofolate reductase folA 0.0009
3544 Dihydrofolate reductase folA 0.0009
3682 Dihydrofolate reductase folA 0.0009
6642 Dihydrofolate reductase folA 0.0009
6756 Dihydrofolate reductase dfrA 0.0009
4439 Ferredoxin reductase bphA4 0.0009
4486 Phenol 2-hydroxylase component B pheA2 0.0009
4477 Dihydrolipoyl dehydrogenase lpdV 0.0009
5077 Dihydrolipoyl dehydrogenase Not Available 0.0009
5117 Dihydrolipoyl dehydrogenase lpd 0.0009
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
5078 Amine oxidase, flavin-containing PSPTO1126 0.0009
5095 Putidaredoxin reductase camA 0.0009
5122 Mersacidin decarboxylase mrsD 0.0009
526 Thioredoxin reductase trxB 0.0009
3767 Thioredoxin reductase trxB 0.0009
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0009
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5109 Outer membrane protein p64k or PM-6 m-6 0.0009
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0009
5115 FkbI fkbI 0.0009
3133 UDP-galactopyranose mutase glf 0.0009
5099 UDP-galactopyranose mutase glf 0.0009
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0009
5083 Cryptochrome DASH cry 0.0009
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0009
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0009
3763 5,10-methylenetetrahydrofolate reductase metF 0.0009
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0009
5094 5,10-methylenetetrahydrofolate reductase metF 0.0009
5081 L-aspartate oxidase nadB 0.0009
5111 Phenylacetone monooxygenase pamO 0.0009
1410 Oxidoreductase HSD17B6 0.0008
4725 Oxidoreductase Not Available 0.0008
5124 Oxidoreductase Not Available 0.0008
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
357 Carbonic anhydrase 2 CA2 0.0008
3830 Calreticulin CALR 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
811 Translocator protein TSPO 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
4440 NADH peroxidase npr 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
976 Platelet glycoprotein IX GP9 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
327 Glutathione reductase gor 0.0007
5110 Glutathione reductase GR2 0.0007
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
3594 Deoxyribodipyrimidine photo-lyase phr 0.0007
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0007
5080 Deoxyribodipyrimidine photo-lyase phr 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
5072 N,N-dimethylglycine oxidase dmg 0.0007
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0007
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2470 Pyruvate oxidase pox5 0.0007
5073 Ferredoxin--NADP reductase petH 0.0007
5076 Ferredoxin--NADP reductase fpr 0.0007
5119 Ferredoxin--NADP reductase petH 0.0007
5121 Ferredoxin--NADP reductase fpr 0.0007
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0007
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0007
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0007
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0007
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0007
2268 Cholesterol oxidase choB 0.0007
2822 Cholesterol oxidase choA 0.0007
2526 NADPH-ferredoxin reductase fprA fprA 0.0007
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0007
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
822 Aldose reductase AKR1B1 0.0007
126 D-lactate dehydrogenase dld 0.0007
3545 D-lactate dehydrogenase Not Available 0.0007
4510 D-lactate dehydrogenase ldhA 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0007
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
2893 Glycine oxidase thiO 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0006
2769 P-hydroxybenzoate hydroxylase pobA 0.0006
2809 P-hydroxybenzoate hydroxylase pobA 0.0006
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0006
2567 Thymidylate synthase thyX thyX 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
2823 Trypanothione reductase TPR 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0006
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
6645 D-amino-acid oxidase DAO 0.0006
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0006
2380 Monomeric sarcosine oxidase soxA 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1864 RET proto-oncogene RET 0.0006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0006
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
798 Osteocalcin BGLAP 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0005
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
896 Glutathione S-transferase Mu 1 GSTM1 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
172 Potassium channel subfamily K member 1 KCNK1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
165 FL cytokine receptor FLT3 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0004
614 Progesterone receptor PGR 0.0003
6085 Fatty acid-binding protein, intestinal FABP2 0.0003
2981 Phospholipase A2, membrane associated PLA2G2A 0.0003
54 Prothrombin F2 0.0003
738 Monocarboxylate transporter 1 SLC16A1 0.0003
7 Nitric oxide synthase, inducible NOS2 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
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