DT-Web

DB00206 - Reserpine


Identification
Name Reserpine
Accession Number DB00206 (APRD00472)
Type small molecule
Description An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 608.6787
Groups approved
Monoisotopic Weight 608.273380888
Pharmacology
Indication Foe the treatment of hypertension
Mechanism of action Reserpine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.
Absorption Not Available
Protein binding 62%
Biotransformation Not Available
Route of elimination Reserpine is extensively metabolized to inactive compounds. It is slowly excreted via the urine and feces.
Toxicity Possible human carcinogen. May cause reproductive harm. ORL-RAT LD50 420 mg/kg; IPR-RAT LD50 44 mg/kg; IVN-RAT LD50 15 mg/kg; ORL-MUS LD50 200 mg/kg; SCU-MUS LD50 52 mg/kg; IPR-RBT LD50 7 mg/kg
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Dobutamine Increased arterial pressure
Dopamine Increased arterial pressure
Ephedra Increased arterial pressure
Ephedrine Increased arterial pressure
Epinephrine Increased arterial pressure
Fenoterol Increased arterial pressure
Iobenguane May diminish the therapeutic effect and increase chances of producing a false negative imaging result of Iobenguane as it depletes or inhibit reuptake of noradrenaline stores
Isoproterenol Increased arterial pressure
Mephentermine Increased arterial pressure
Metaraminol Increased arterial pressure
Methoxamine Increased arterial pressure
Norepinephrine Increased arterial pressure
Orciprenaline Increased arterial pressure
Phenylephrine Increased arterial pressure
Phenylpropanolamine Increased arterial pressure
Pirbuterol Increased arterial pressure
Procaterol Increased arterial pressure
Pseudoephedrine Increased arterial pressure
Salbutamol Increased arterial pressure
Terbutaline Increased arterial pressure
Tetrabenazine Reserpine may increase the adverse/toxic effects of tetrabenazine as they have similar pharmacologic properties. Concomitant therapy is contraindicated.
Topotecan The p-glycoprotein inhibitor, Reserpine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tranylcypromine Addition of Reserpine to Tranylcypromine therapy may induce paradoxical Reserpine effects, including peripheral hypertension and central exciation. Close monitoring for adverse effects is required. Addition of Tranylcypromine to Reserpine therapy may be less of a concern.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Triprolidine The CNS depressants, Triprolidine and Reserpine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Food Interactions
  • Magnesium, potassium and zinc needs increased.
  • Take with food to reduce irritation. Avoid alcohol.

Targets


Synaptic vesicular amine transporter
Name Synaptic vesicular amine transporter
Gene Name SLC18A2
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sievert MK, Hajipour AR, Ruoho AE: Specific derivatization of the vesicle monoamine transporter with novel carrier-free radioiodinated reserpine and tetrabenazine photoaffinity labels. Anal Biochem. 2007 Aug 1;367(1):68-78. Epub 2007 May 3. - Pubmed
  • Naudon L, Leroux-Nicollet I, Raisman-Vozari R, Botton D, Costentin J: Time-course of modifications elicited by reserpine on the density and mRNA synthesis of the vesicular monoamine transporter, and on the density of the membrane dopamine uptake complex. Synapse. 1995 Sep;21(1):29-36. - Pubmed
  • Erickson JD, Eiden LE, Hoffman BJ: Expression cloning of a reserpine-sensitive vesicular monoamine transporter. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10993-7. - Pubmed
  • Mandela P, Chandley M, Xu YY, Zhu MY, Ordway GA: Reserpine-induced reduction in norepinephrine transporter function requires catecholamine storage vesicles. Neurochem Int. 2010 May-Jun;56(6-7):760-7. Epub 2010 Feb 20. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5383

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2589

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor,inducer
References
  • Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. - Pubmed
  • Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. - Pubmed
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
  • Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. - Pubmed
  • Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):765-72. - Pubmed
  • Horie K, Tang F, Borchardt RT: Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharm Res. 2003 Feb;20(2):161-8. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
  • Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
DTHybrid score 0.3809
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Grundemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H: Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 1994 Dec 8;372(6506):549-52. - Pubmed
DTHybrid score 0.2975
Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed
  • Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed
DTHybrid score 0.1859
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. - Pubmed
DTHybrid score 0.242
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate
References
  • Grundemann D, Koster S, Kiefer N, Breidert T, Engelhardt M, Spitzenberger F, Obermuller N, Schomig E: Transport of monoamine transmitters by the organic cation transporter type 2, OCT2. J Biol Chem. 1998 Nov 20;273(47):30915-20. - Pubmed
DTHybrid score 0.2446

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2729
4119 Cytochrome P450 2D6 CYP2D6 0.1812
6107 Cytochrome P450 3A7 CYP3A7 0.156
4757 Cytochrome P450 2C9 CYP2C9 0.124
6016 Cytochrome P450 2C19 CYP2C19 0.1213
4200 Cytochrome P450 1A2 CYP1A2 0.1148
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1102
4924 Cytochrome P450 2C8 CYP2C8 0.1083
1636 Trace amine-associated receptor 1 TAAR1 0.1025
556 Alpha-1A adrenergic receptor ADRA1A 0.1002
862 Multidrug resistance-associated protein 1 ABCC1 0.0936
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.093
6147 Solute carrier family 22 member 3 SLC22A3 0.092
118 Organic cation/carnitine transporter 2 SLC22A5 0.0894
713 Sodium-dependent dopamine transporter SLC6A3 0.0847
6030 Cytochrome P450 2B6 CYP2B6 0.08
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0781
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0747
6024 Cytochrome P450 1A1 CYP1A1 0.0679
824 Sodium-dependent serotonin transporter SLC6A4 0.063
6142 Solute carrier family 22 member 8 SLC22A8 0.0608
1729 Solute carrier family 22 member 6 SLC22A6 0.0595
587 Serum albumin ALB 0.0568
833 Organic cation/carnitine transporter 1 SLC22A4 0.0561
6141 Sodium/bile acid cotransporter SLC10A1 0.0542
6013 Cytochrome P450 2E1 CYP2E1 0.0542
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0522
831 D(2) dopamine receptor DRD2 0.0479
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0473
318 Alpha-2A adrenergic receptor ADRA2A 0.0473
2164 Multidrug resistance-associated protein 4 ABCC4 0.0445
5718 Cytochrome P450 2A6 CYP2A6 0.044
502 5-hydroxytryptamine 2A receptor HTR2A 0.044
3939 Amine oxidase [flavin-containing] B MAOB 0.0433
6148 Multidrug resistance-associated protein 7 ABCC10 0.0428
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0414
1898 Cytochrome P450 1B1 CYP1B1 0.0408
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0408
3941 Amine oxidase [flavin-containing] A MAOA 0.0394
766 Beta-2 adrenergic receptor ADRB2 0.0386
6143 Solute carrier family 22 member 7 SLC22A7 0.038
3923 Cholinesterase BCHE 0.0379
193 Beta-1 adrenergic receptor ADRB1 0.0365
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0354
632 Alpha-1B adrenergic receptor ADRA1B 0.0345
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0328
378 Alpha-2C adrenergic receptor ADRA2C 0.0325
474 Acetylcholinesterase ACHE 0.0307
1024 Solute carrier family 22 member 11 SLC22A11 0.0303
629 Alpha-2B adrenergic receptor ADRA2B 0.0301
6137 Multidrug resistance-associated protein 6 ABCC6 0.0294
817 DNA topoisomerase 2-alpha TOP2A 0.0293
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0293
492 Histamine H1 receptor HRH1 0.0287
136 Estrogen receptor ESR1 0.0282
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0279
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0254
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0254
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0251
4120 NADPH--cytochrome P450 reductase POR 0.0247
320 5-hydroxytryptamine 1A receptor HTR1A 0.0244
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0243
6106 Cytochrome P450 2C18 CYP2C18 0.0238
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0237
23 D(1A) dopamine receptor DRD1 0.0233
477 DNA topoisomerase 4 subunit A parC 0.0229
886 DNA topoisomerase 4 subunit A parC 0.0229
6226 DNA topoisomerase 4 subunit A parC 0.0229
124 Histamine H2 receptor HRH2 0.0228
404 DNA gyrase subunit A gyrA 0.0225
6224 DNA gyrase subunit A gyrA 0.0225
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0212
341 5-hydroxytryptamine 3 receptor HTR3A 0.0211
20 Prostaglandin G/H synthase 1 PTGS1 0.021
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0209
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0204
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0204
3811 Cytochrome P450 19A1 CYP19A1 0.0201
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0196
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0195
70 Type-1 angiotensin II receptor AGTR1 0.0194
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0193
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0193
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0188
2808 Chloramphenicol acetyltransferase 3 cat3 0.0187
683 Potassium transporter GK0582 0.0185
590 5-hydroxytryptamine 2C receptor HTR2C 0.0184
614 Progesterone receptor PGR 0.0184
3270 Elongation factor G fusA 0.0181
436 5-hydroxytryptamine 2B receptor HTR2B 0.0179
731 HIV-1 protease HIV-1 protease 0.0179
871 Glucocorticoid receptor NR3C1 0.0177
6031 Cytochrome P450 3A43 CYP3A43 0.0177
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0176
738 Monocarboxylate transporter 1 SLC16A1 0.0172
6136 Multidrug resistance-associated protein 5 ABCC5 0.0171
161 Tubulin beta chain TUBB 0.0168
312 Tubulin beta chain TUB2 0.0168
789 Alpha-1D adrenergic receptor ADRA1D 0.0168
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0167
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0165
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0164
4773 Deoxycytidine kinase DCK 0.0161
6010 Thiamine transporter 1 SLC19A2 0.0159
7 Nitric oxide synthase, inducible NOS2 0.0157
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0155
737 Mineralocorticoid receptor NR3C2 0.0154
1517 Beta-3 adrenergic receptor ADRB3 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0146
468 Cytochrome P450 4A11 CYP4A11 0.0146
3947 Xanthine dehydrogenase/oxidase XDH 0.0146
4604 Liver carboxylesterase 1 CES1 0.0144
847 Mu-type opioid receptor OPRM1 0.0144
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0137
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0136
504 Mast/stem cell growth factor receptor KIT 0.0135
638 D(3) dopamine receptor DRD3 0.0128
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0122
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0121
465 Calmodulin CALM1 0.0121
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.012
6167 Organic solute transporter subunit beta OSTB 0.012
6166 Organic solute transporter subunit alpha OSTA 0.012
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0119
908 Glutathione S-transferase theta-1 GSTT1 0.0118
6182 Cytochrome P450 2J2 CYP2J2 0.0117
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0115
1629 Transcription factor AP-1 JUN 0.0114
756 Sex hormone-binding globulin SHBG 0.0114
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0113
49 Endothelin B receptor EDNRB 0.0113
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0113
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0113
467 Delta-type opioid receptor OPRD1 0.0113
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
290 Prostaglandin G/H synthase 2 PTGS2 0.0109
4203 Histamine N-methyltransferase HNMT 0.0109
869 Estrogen receptor beta ESR2 0.0109
6211 Tubulin epsilon chain TUBE1 0.0109
6210 Tubulin delta chain TUBD1 0.0108
6212 Tubulin gamma-1 chain TUBG1 0.0108
380 Cytochrome P450 17A1 CYP17A1 0.0108
2443 Azurin azu 0.0108
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0107
2449 Tubulin alpha-3 chain TUBA1A 0.0107
33 Cystine/glutamate transporter SLC7A11 0.0107
578 Endothelin-1 receptor EDNRA 0.0106
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0106
887 DNA gyrase subunit B gyrB 0.0105
4150 DNA gyrase subunit B gyrB 0.0105
6225 DNA gyrase subunit B gyrB 0.0105
260 Cytochrome P450 51 ERG11 0.0105
761 Cytochrome P450 51 ERG11 0.0105
3163 Cytochrome P450 51 cyp51 0.0105
228 Beta platelet-derived growth factor receptor PDGFRB 0.0105
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0104
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0104
885 5-hydroxytryptamine 1B receptor HTR1B 0.0103
696 Kappa-type opioid receptor OPRK1 0.0103
904 Glutathione S-transferase P GSTP1 0.0102
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0101
29 Tubulin beta-1 chain TUBB1 0.0101
274 Muscarinic acetylcholine receptor M5 CHRM5 0.01
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.01
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0099
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0098
6165 Copper-transporting ATPase 1 ATP7A 0.0098
6163 Copper-transporting ATPase 2 ATP7B 0.0098
1852 Microtubule-associated protein 2 MAP2 0.0098
694 Matrix protein 2 M 0.0098
4192 DNA topoisomerase 2-beta TOP2B 0.0098
2539 Tubulin alpha-1 chain TUBA4A 0.0098
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0098
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
407 Vascular endothelial growth factor receptor 2 KDR 0.0097
185 Vasopressin V1a receptor AVPR1A 0.0096
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0096
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0095
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0095
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0095
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0095
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0095
844 Epidermal growth factor receptor EGFR 0.0095
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0094
6146 High affinity copper uptake protein 1 SLC31A1 0.0094
322 Vasopressin V2 receptor AVPR2 0.0093
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0093
1770 Phospholipase C PLCL1 0.0093
2841 Phospholipase C plc 0.0093
5626 Nucleoside diphosphate kinase B NME2 0.0092
1192 Sulfotransferase 1A1 SULT1A1 0.0091
165 FL cytokine receptor FLT3 0.0091
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0091
26 Vascular endothelial growth factor receptor 3 FLT4 0.009
5923 Microtubule-associated protein tau MAPT 0.0089
5924 Microtubule-associated protein 4 MAP4 0.0089
6070 Nischarin NISCH 0.0089
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0088
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0088
432 D(4) dopamine receptor DRD4 0.0088
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0087
32 Vascular endothelial growth factor receptor 1 FLT1 0.0086
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0085
725 5-hydroxytryptamine 1D receptor HTR1D 0.0085
896 Glutathione S-transferase Mu 1 GSTM1 0.0084
777 Tumor necrosis factor TNF 0.0083
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0083
273 Apoptosis regulator Bcl-2 BCL2 0.0082
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0081
850 Vasopressin V1b receptor AVPR1B 0.0081
2472 Voltage-gated potassium channel kcsA 0.0081
6366 Voltage-gated potassium channel kcsA 0.0081
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.008
6171 Solute carrier family 28 member 3 SLC28A3 0.0079
1757 Myeloperoxidase MPO 0.0079
146 Androgen receptor AR 0.0079
1830 5'-nucleotidase NT5E 0.0077
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0077
3587 Gastrotropin FABP6 0.0076
723 Cytosolic phospholipase A2 PLA2G4A 0.0076
24 Thymidylate synthase TMP1 0.0075
359 Thymidylate synthase TYMS 0.0075
2626 Thymidylate synthase thyA 0.0075
2729 Thymidylate synthase thyA 0.0075
5352 Thymidylate synthase THYA 0.0075
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0075
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0075
3611 Cytidine deaminase cdd 0.0074
3707 Cytidine deaminase cdd 0.0074
4211 Cytidine deaminase CDA 0.0074
125 DNA polymerase beta POLB 0.0074
5294 Nucleoside diphosphate kinase A NME1 0.0074
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0074
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0073
275 Arachidonate 5-lipoxygenase ALOX5 0.0073
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0072
1353 DNA topoisomerase 1 TOP1 0.0071
3552 DNA topoisomerase 1 topA 0.0071
163 D(1B) dopamine receptor DRD5 0.007
751 Potassium channel subfamily K member 6 KCNK6 0.0069
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0069
702 UMP-CMP kinase CMPK1 0.0068
342 P protein [Includes: DNA-directed DNA polymerase P 0.0068
612 P protein [Includes: DNA-directed DNA polymerase P 0.0068
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0068
828 Phenylalanine-4-hydroxylase PAH 0.0068
3109 Phenylalanine-4-hydroxylase phhA 0.0068
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0068
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0068
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0066
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0066
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0066
5126 Arginase rocF 0.0064
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0064
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0064
172 Potassium channel subfamily K member 1 KCNK1 0.0063
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
976 Platelet glycoprotein IX GP9 0.0063
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0062
952 Dipeptidyl peptidase 4 DPP4 0.0062
6085 Fatty acid-binding protein, intestinal FABP2 0.0062
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0062
4148 Serine/threonine-protein kinase mTOR MTOR 0.0061
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0061
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0061
164 Histamine H4 receptor HRH4 0.006
1341 Histamine H3 receptor HRH3 0.006
6149 Solute carrier family 22 member 10 SLC22A10 0.006
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.006
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0059
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0059
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0059
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
469 Annexin A1 ANXA1 0.0059
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0059
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0058
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0057
232 Corticosteroid-binding globulin SERPINA6 0.0057
1010 Cytochrome P450 51A1 CYP51A1 0.0056
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0055
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0055
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0055
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0055
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0055
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0055
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0055
3809 Estrogen-related receptor gamma ESRRG 0.0054
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0054
153 Dopamine beta-hydroxylase DBH 0.0054
6432 Transporter snf 0.0054
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0054
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0053
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0053
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0052
823 Fibroblast growth factor receptor 2 FGFR2 0.0052
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0052
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0052
2216 Fibroblast growth factor receptor 4 FGFR4 0.0051
3856 Fibroblast growth factor receptor 3 FGFR3 0.0051
624 Guanidinoacetate N-methyltransferase GAMT 0.005
6220 Aryl hydrocarbon receptor AHR 0.005
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.005
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
6824 Tyrosine-protein kinase Lyn LYN 0.005
84 Nuclear receptor 0B1 NR0B1 0.0049
122 P2Y purinoceptor 12 P2RY12 0.0049
1618 High affinity nerve growth factor receptor NTRK1 0.0049
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0049
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0048
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0048
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0048
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0048
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0048
1650 Heme carrier protein 1 SLC46A1 0.0048
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0048
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0047
2300 Lysozyme E 0.0047
3633 Lysozyme R 0.0047
5597 Lysozyme 17 0.0047
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0047
6218 Pannexin-1 PANX1 0.0047
461 Glycine receptor subunit alpha-3 GLRA3 0.0047
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0047
239 Coagulation factor X F10 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0047
1864 RET proto-oncogene RET 0.0046
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0046
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0046
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0046
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0045
489 Monocarboxylate transporter 2 SLC16A7 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
4238 50S ribosomal protein L4 rplD 0.0045
5578 50S ribosomal protein L4 rplD 0.0045
6173 50S ribosomal protein L4 rplD 0.0045
6219 50S ribosomal protein L4 rplD 0.0045
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0045
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0043
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0043
818 50S ribosomal protein L10 rplJ 0.0042
705 Glutamate receptor 1 GRIA1 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
6599 HTH-type transcriptional regulator ttgR ttgR 0.0041
5300 Antigen peptide transporter 1 TAP1 0.0041
6014 Cytochrome P450 2A13 CYP2A13 0.0041
4237 50S ribosomal protein L22 rplV 0.0041
3810 Catechol O-methyltransferase COMT 0.0041
811 Translocator protein TSPO 0.0041
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0041
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.004
1656 CYP2B protein CYP2B 0.004
5787 Angiopoietin-1 receptor TEK 0.004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.004
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.004
484 Tyrosine-protein kinase ABL2 ABL2 0.0039
716 5-hydroxytryptamine 7 receptor HTR7 0.0039
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0037
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0037
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0037
1630 Integrin beta-2 ITGB2 0.0037
284 DNA-directed RNA polymerase beta chain rpoB 0.0037
5773 DNA-directed RNA polymerase beta chain rpoB 0.0037
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0037
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0037
527 Prostacyclin receptor PTGIR 0.0036
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0036
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0036
3926 Choline transporter-like protein 2 SLC44A2 0.0036
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0036
1686 Choline transporter-like protein 1 SLC44A1 0.0036
3927 Choline transporter-like protein 3 SLC44A3 0.0036
861 Choline kinase alpha CHKA 0.0036
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0036
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0036
3925 Choline transporter-like protein 4 SLC44A4 0.0036
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0036
769 High-affinity choline transporter 1 SLC5A7 0.0036
700 Choline dehydrogenase, mitochondrial CHDH 0.0036
576 Choline O-acetyltransferase CHAT 0.0036
3922 Phospholipase D2 PLD2 0.0036
3924 Phospholipase D1 PLD1 0.0036
1569 G1/S-specific cyclin-D1 CCND1 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
340 Apoptotic protease-activating factor 1 APAF1 0.0035
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0035
319 Opioid receptor, sigma 1 OPRS1 0.0035
2391 Ferrochelatase hemH 0.0035
6502 Ferrochelatase DKFZp686P18130 0.0035
1591 Ferrochelatase, mitochondrial FECH 0.0035
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0035
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0035
5934 Cytochrome P450 26A1 CYP26A1 0.0035
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0035
54 Prothrombin F2 0.0034
6168 Solute carrier family 22 member 16 SLC22A16 0.0034
267 Plasminogen activator inhibitor 1 SERPINE1 0.0034
1760 Aminopeptidase N ANPEP 0.0034
6843 Aminopeptidase N pepN 0.0034
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0033
117 Sterol O-acyltransferase 1 SOAT1 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
1360 Sphingomyelin phosphodiesterase SMPD1 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
427 Substance-P receptor TACR1 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0031
825 Arsenical pump-driving ATPase ASNA1 0.0031
3435 Arsenical pump-driving ATPase arsA 0.0031
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0031
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0031
154 AFG3-like protein 2 AFG3L2 0.0031
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0031
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0031
733 Activin receptor type 1B ACVR1B 0.0031
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0031
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0031
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0031
395 ALK tyrosine kinase receptor Not Available 0.0031
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0031
6221 Steroid hormone receptor ERR1 ESRRA 0.0031
4217 Telomerase reverse transcriptase TERT 0.0031
2599 Tyrosine-protein kinase HCK HCK 0.003
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.003
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.003
6044 Serum paraoxonase/lactonase 3 PON3 0.003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.003
6493 Cytochrome c oxidase subunit 6C COX6C 0.003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.003
6559 Cytochrome c oxidase subunit 2 ctaC 0.003
6669 Cytochrome c oxidase subunit 2 ctaC 0.003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.003
6558 Cytochrome c oxidase subunit 1 ctaD 0.003
1714 Mitogen-activated protein kinase 3 MAPK3 0.0029
2112 Toll-like receptor 9 TLR9 0.0029
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0029
292 Activin receptor type-1 ACVR1 0.0029
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
849 Activated CDC42 kinase 1 TNK2 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
572 Integrin alpha-L ITGAL 0.0028
2540 Choloylglycine hydrolase cbh 0.0028
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0027
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0027
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0027
297 Adenylate cyclase type 1 ADCY1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
3932 Glutathione S-transferase A2 GSTA2 0.0027
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0027
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0027
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0027
6020 Aldehyde oxidase AOX1 0.0027
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0027
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
6174 50S ribosomal protein L32 rpmF 0.0026
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0026
6837 Serine/threonine-protein kinase 17B STK17B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1256 5-hydroxytryptamine 6 receptor HTR6 0.0026
6501 Fatty acid-binding protein, liver FABP1 0.0026
4122 Histone deacetylase 2 HDAC2 0.0025
528 5-hydroxytryptamine 1E receptor HTR1E 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0025
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0025
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0025
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0024
1176 Mitogen-activated protein kinase 1 MAPK1 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
2320 Thymidine kinase, cytosolic TK1 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
740 Argininosuccinate synthase ASS1 0.0023
865 Argininosuccinate synthase ASS1 0.0023
2680 Argininosuccinate synthase argG 0.0023
3194 Argininosuccinate synthase argG 0.0023
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0023
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0023
76 Nitric-oxide synthase, brain NOS1 0.0023
1525 Heparin-binding growth factor 2 FGF2 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
373 Transthyretin TTR 0.0023
661 ADP/ATP translocase 1 SLC25A4 0.0023
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0023
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0023
6021 Adenosine kinase ADK 0.0023
3086 Plasmepsin-2 Not Available 0.0023
291 Nitric-oxide synthase, endothelial NOS3 0.0023
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0023
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
1178 Adenosine A2a receptor ADORA2A 0.0022
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0022
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0022
6500 Phospholipase A2 PLA2G1B 0.0021
3917 Methylenetetrahydrofolate reductase MTHFR 0.0021
94 5-hydroxytryptamine 4 receptor HTR4 0.0021
921 Glutamate receptor 2 GRIA2 0.0021
4311 tRNA TRDMT1 0.0021
4325 tRNA trmD 0.0021
4328 tRNA trmD 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0019
517 Alcohol dehydrogenase 1C ADH1C 0.0019
365 Dihydrofolate reductase DHFR 0.0019
2381 Dihydrofolate reductase DFR1 0.0019
2833 Dihydrofolate reductase Not Available 0.0019
2931 Dihydrofolate reductase folA 0.0019
3544 Dihydrofolate reductase folA 0.0019
3682 Dihydrofolate reductase folA 0.0019
6642 Dihydrofolate reductase folA 0.0019
6756 Dihydrofolate reductase dfrA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0019
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0019
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0019
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
936 Ephrin type-A receptor 2 EPHA2 0.0018
594 Thyroxine-binding globulin SERPINA7 0.0017
1313 Lactoylglutathione lyase GLO1 0.0017
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0016
1063 Signal transducer and activator of transcription 5B STAT5B 0.0016
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0016
814 Ryanodine receptor 1 RYR1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
1196 Complement decay-accelerating factor CD55 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6755 Poliovirus receptor PVR 0.0015
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0015
5818 Folate receptor alpha FOLR1 0.0015
6042 Prostaglandin reductase 2 PTGR2 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
174 Sigma 1-type opioid receptor SIGMAR1 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
780 Retinoic acid receptor RXR-gamma RXRG 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0014
6043 Putative G-protein coupled receptor 44 GPR44 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
2981 Phospholipase A2, membrane associated PLA2G2A 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
293 Gamma-glutamyl hydrolase GGH 0.0013
88 Retinoic acid receptor RXR-beta RXRB 0.0013
6102 Arylamine N-acetyltransferase 2 NAT2 0.0013
16 Adenosine A1 receptor ADORA1 0.0013
162 Retinoic acid receptor gamma-1 RARG 0.0013
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0013
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2417 Chloramphenicol acetyltransferase cat 0.0012
3278 Chloramphenicol acetyltransferase cat 0.0012
3601 Dihydropteroate synthase 1 folP1 0.0012
3807 Dihydropteroate synthase 1 folP1 0.0012
3808 Dihydropteroate synthase 2 folP2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2810 Dr hemagglutinin structural subunit draA 0.0012
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0012
3913 Glutamic acid decarboxylase GAD65 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
6459 Glycodelin PAEP 0.0011
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0011
1483 Membrane copper amine oxidase AOC3 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.001
106 Cannabinoid receptor 2 CNR2 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
3904 Alanine aminotransferase 2 GPT2 0.001
735 Alanine aminotransferase 1 GPT 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
3957 Adenosine deaminase ADA 0.0009
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
295 Carbonic anhydrase 1 CA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1039 Histone deacetylase 9 HDAC9 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0006
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
2021 Thrombomodulin THBD 0.0005
2207 Rhodopsin RHO 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
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