DT-Web: DB00988

Identification

Name

Dopamine

Accession Number

DB00988 (APRD00085)

Type

small molecule

Description

One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

153.1784

Groups

approved

Monoisotopic Weight

153.078978601

Pharmacology

Indication

For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure

Mechanism of action

Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. In the brain, dopamine actas as an agonist to the five dopamine receptor subtypes (D!, D2, D3, D4, D5).

Absorption

Dopamine is rapidly absorbed from the small intestine.

Protein binding

No information currently available on protein binding.

Biotransformation

Biotransformation of dopamine proceeds rapidly to yield the principal excretion products, 3-4-dihydroxy-phenylacetic acid (DOPAC) and 3-methoxy-4-hydroxy-phenylacetic acid (homovanillic acid, HVA).

Route of elimination

It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid. A very small portion is excreted unchanged.

Toxicity

LD₅₀ oral mice = 1460 mg/kg, LD₅₀ oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amitriptyline	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect, dopamine.
Amoxapine	The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of dopamine.
Clomipramine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of dopamine.
Desipramine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of dopamine.
Doxepin	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of dopamine.
Entacapone	Entacapone increases the effect and toxicity of the sympathomimetic, dopamine.
Fosphenytoin	Risk of severe hypotension
Guanethidine	Dopamine may decrease the effect of guanethidine.
Imipramine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of dopamine.
Isocarboxazid	Increased arterial pressure
Linezolid	Possible increase of arterial pressure
Lurasidone	Dopamine increases toxicity (enhanced hypotensive effects) of lurasidone.
Methyldopa	Increased arterial pressure
Midodrine	Increased arterial pressure
Moclobemide	Moclobemide increases the sympathomimetic effect of dopamine.
Nortriptyline	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of dopamine.
Phenelzine	Increased arterial pressure
Phenytoin	Risk of severe hypotension
Rasagiline	Increased arterial pressure
Reserpine	Increased arterial pressure

Food Interactions

Not Available

D(2) dopamine receptor
Name	D(2) dopamine receptor
Gene Name	DRD2
Pharmacological action	yes
Actions	agonist
References	Ostadali MR, Ahangari G, Eslami MB, Razavi A, Zarrindast MR, Ahmadkhaniha HR, Boulhari J: The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6185
D(1A) dopamine receptor
Name	D(1A) dopamine receptor
Gene Name	DRD1
Pharmacological action	yes
Actions	agonist
References	Ostadali MR, Ahangari G, Eslami MB, Razavi A, Zarrindast MR, Ahmadkhaniha HR, Boulhari J: The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74. - Pubmed Dolzan V, Plesnicar BK, Serretti A, Mandelli L, Zalar B, Koprivsek J, Breskvar K: Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment. Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 5;144(6):809-15. - Pubmed Hoenicka J, Aragues M, Ponce G, Rodriguez-Jimenez R, Jimenez-Arriero MA, Palomo T: From dopaminergic genes to psychiatric disorders. Neurotox Res. 2007 Jan;11(1):61-72. - Pubmed da Silva Lobo DS, Vallada HP, Knight J, Martins SS, Tavares H, Gentil V, Kennedy JL: Dopamine genes and pathological gambling in discordant sib-pairs. J Gambl Stud. 2007 Dec;23(4):421-33. Epub 2007 Mar 30. - Pubmed Fu W, Shen J, Luo X, Zhu W, Cheng J, Yu K, Briggs JM, Jin G, Chen K, Jiang H: Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations. Biophys J. 2007 Sep 1;93(5):1431-41. Epub 2007 Apr 27. - Pubmed
DTHybrid score	0.531
D(1B) dopamine receptor
Name	D(1B) dopamine receptor
Gene Name	DRD5
Pharmacological action	yes
Actions	agonist
References	Ostadali MR, Ahangari G, Eslami MB, Razavi A, Zarrindast MR, Ahmadkhaniha HR, Boulhari J: The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74. - Pubmed
DTHybrid score	0.3339
D(3) dopamine receptor
Name	D(3) dopamine receptor
Gene Name	DRD3
Pharmacological action	yes
Actions	agonist
References	Ostadali MR, Ahangari G, Eslami MB, Razavi A, Zarrindast MR, Ahmadkhaniha HR, Boulhari J: The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74. - Pubmed
DTHybrid score	0.3607
D(4) dopamine receptor
Name	D(4) dopamine receptor
Gene Name	DRD4
Pharmacological action	yes
Actions	agonist
References	Ostadali MR, Ahangari G, Eslami MB, Razavi A, Zarrindast MR, Ahmadkhaniha HR, Boulhari J: The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74. - Pubmed
DTHybrid score	0.3426
Sodium-dependent dopamine transporter
Name	Sodium-dependent dopamine transporter
Gene Name	SLC6A3
Pharmacological action	yes
Actions	inducer
References	Ostadali MR, Ahangari G, Eslami MB, Razavi A, Zarrindast MR, Ahmadkhaniha HR, Boulhari J: The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74. - Pubmed
DTHybrid score	0.5059
Dopamine beta-hydroxylase
Name	Dopamine beta-hydroxylase
Gene Name	DBH
Pharmacological action	yes
Actions	ligand
References	Goldman JM, Cooper RL, Murr AS: Reproductive functions and hypothalamic catecholamines in response to the soil fumigant metam sodium: adaptations to extended exposures. Neurotoxicol Teratol. 2007 May-Jun;29(3):368-76. Epub 2006 Dec 6. - Pubmed Arboleda G, Huang TJ, Waters C, Verkhratsky A, Fernyhough P, Gibson RM: Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. Eur J Neurosci. 2007 May;25(10):3030-8. - Pubmed Garland EM, Black BK, Harris PA, Robertson D: Dopamine-beta-hydroxylase in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H684-90. - Pubmed Pyatskowit JW, Prohaska JR: Rodent brain and heart catecholamine levels are altered by different models of copper deficiency. Comp Biochem Physiol C Toxicol Pharmacol. 2007 Mar;145(2):275-81. Epub 2007 Jan 12. - Pubmed LeBlanc J, Ducharme MB: Plasma dopamine and noradrenaline variations in response to stress. Physiol Behav. 2007 Jun 8;91(2-3):208-11. Epub 2007 Mar 2. - Pubmed
DTHybrid score	0.2868

Amine oxidase [flavin-containing] A
Name	Amine oxidase [flavin-containing] A
Gene Name	MAOA
Actions	substrate
References	- Bortolato M, Chen K, Shih JC: Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1527-33. Epub 2008 Jul 4. - Pubmed Kaludercic N, Carpi A, Menabo R, Di Lisa F, Paolocci N: Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury. Biochim Biophys Acta. 2011 Jul;1813(7):1323-32. Epub 2010 Sep 24. - Pubmed Volavka J, Bilder R, Nolan K: Catecholamines and aggression: the role of COMT and MAO polymorphisms. Ann N Y Acad Sci. 2004 Dec;1036:393-8. - Pubmed
DTHybrid score	0.6877
Amine oxidase [flavin-containing] B
Name	Amine oxidase [flavin-containing] B
Gene Name	MAOB
Actions	substrate
References	- Bortolato M, Chen K, Shih JC: Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1527-33. Epub 2008 Jul 4. - Pubmed Kaludercic N, Carpi A, Menabo R, Di Lisa F, Paolocci N: Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury. Biochim Biophys Acta. 2011 Jul;1813(7):1323-32. Epub 2010 Sep 24. - Pubmed
DTHybrid score	1.0795
Catechol O-methyltransferase
Name	Catechol O-methyltransferase
Gene Name	COMT
Actions	substrate
References	- Ittiwut R, Listman JB, Ittiwut C, Cubells JF, Weiss RD, Brady K, Oslin D, Farrer LA, Kranzler HR, Gelernter J: Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. Am J Med Genet B Neuropsychiatr Genet. 2011 Sep;156(6):651-60. doi: 10.1002/ajmg.b.31205. Epub 2011 Jun 8. - Pubmed Boot E, Booij J, Abeling N, Meijer J, da Silva Alves F, Zinkstok J, Baas F, Linszen D, van Amelsvoort T: Dopamine metabolism in adults with 22q11 deletion syndrome, with and without schizophrenia - relationship with COMT Val108/158 Met polymorphism, gender and symptomatology. J Psychopharmacol. 2011 Jul;25(7):888-95. Epub 2011 Mar 29. - Pubmed Volavka J, Bilder R, Nolan K: Catecholamines and aggression: the role of COMT and MAO polymorphisms. Ann N Y Acad Sci. 2004 Dec;1036:393-8. - Pubmed
DTHybrid score	0.86
Dopamine beta-hydroxylase
Name	Dopamine beta-hydroxylase
Gene Name	DBH
Actions	substrate
References	Goldman JM, Cooper RL, Murr AS: Reproductive functions and hypothalamic catecholamines in response to the soil fumigant metam sodium: adaptations to extended exposures. Neurotoxicol Teratol. 2007 May-Jun;29(3):368-76. Epub 2006 Dec 6. - Pubmed Arboleda G, Huang TJ, Waters C, Verkhratsky A, Fernyhough P, Gibson RM: Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. Eur J Neurosci. 2007 May;25(10):3030-8. - Pubmed Garland EM, Black BK, Harris PA, Robertson D: Dopamine-beta-hydroxylase in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H684-90. - Pubmed Pyatskowit JW, Prohaska JR: Rodent brain and heart catecholamine levels are altered by different models of copper deficiency. Comp Biochem Physiol C Toxicol Pharmacol. 2007 Mar;145(2):275-81. Epub 2007 Jan 12. - Pubmed LeBlanc J, Ducharme MB: Plasma dopamine and noradrenaline variations in response to stress. Physiol Behav. 2007 Jun 8;91(2-3):208-11. Epub 2007 Mar 2. - Pubmed
DTHybrid score	0.2868
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6012
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4717
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5383
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7349

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	substrate,inhibitor
References	Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C, Arndt P, Ulzheimer JC, Sonders MS, Baumann C, Waldegger S, Lang F, Koepsell H: Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. - Pubmed Grundemann D, Koster S, Kiefer N, Breidert T, Engelhardt M, Spitzenberger F, Obermuller N, Schomig E: Transport of monoamine transmitters by the organic cation transporter type 2, OCT2. J Biol Chem. 1998 Nov 20;273(47):30915-20. - Pubmed Verhaagh S, Schweifer N, Barlow DP, Zwart R: Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Genomics. 1999 Jan 15;55(2):209-18. - Pubmed Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
DTHybrid score	0.3784
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	substrate,inhibitor
References	Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed Busch AE, Quester S, Ulzheimer JC, Gorboulev V, Akhoundova A, Waldegger S, Lang F, Koepsell H: Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1. FEBS Lett. 1996 Oct 21;395(2-3):153-6. - Pubmed Breidert T, Spitzenberger F, Grundemann D, Schomig E: Catecholamine transport by the organic cation transporter type 1 (OCT1). Br J Pharmacol. 1998 Sep;125(1):218-24. - Pubmed
DTHybrid score	0.4565
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score	0.3034
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score	0.3574
POU domain, class 5, transcription factor 1
Name	POU domain, class 5, transcription factor 1
Gene Name	POU5F1
Actions	substrate
References	Zhu HJ, Appel DI, Grundemann D, Markowitz JS: Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem. 2010 Jul;114(1):142-9. Epub 2010 Apr 6. - Pubmed
DTHybrid score	0.1848

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.532
502	5-hydroxytryptamine 2A receptor	HTR2A	0.3423
318	Alpha-2A adrenergic receptor	ADRA2A	0.3088
1588	Multidrug resistance protein 1	ABCB1	0.3009
556	Alpha-1A adrenergic receptor	ADRA1A	0.2635
629	Alpha-2B adrenergic receptor	ADRA2B	0.2623
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.2604
378	Alpha-2C adrenergic receptor	ADRA2C	0.253
4118	Cytochrome P450 3A5	CYP3A5	0.2306
320	5-hydroxytryptamine 1A receptor	HTR1A	0.2284
824	Sodium-dependent serotonin transporter	SLC6A4	0.2262
4924	Cytochrome P450 2C8	CYP2C8	0.2176
6013	Cytochrome P450 2E1	CYP2E1	0.212
590	5-hydroxytryptamine 2C receptor	HTR2C	0.2102
632	Alpha-1B adrenergic receptor	ADRA1B	0.2054
492	Histamine H1 receptor	HRH1	0.1862
6030	Cytochrome P450 2B6	CYP2B6	0.1794
725	5-hydroxytryptamine 1D receptor	HTR1D	0.1766
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1692
6107	Cytochrome P450 3A7	CYP3A7	0.1672
436	5-hydroxytryptamine 2B receptor	HTR2B	0.1351
103	Muscarinic acetylcholine receptor M1	CHRM1	0.1314
6024	Cytochrome P450 1A1	CYP1A1	0.1281
833	Organic cation/carnitine transporter 1	SLC22A4	0.127
766	Beta-2 adrenergic receptor	ADRB2	0.1248
193	Beta-1 adrenergic receptor	ADRB1	0.1248
5718	Cytochrome P450 2A6	CYP2A6	0.1196
789	Alpha-1D adrenergic receptor	ADRA1D	0.1134
131	Synaptic vesicular amine transporter	SLC18A2	0.1114
587	Serum albumin	ALB	0.1074
1757	Myeloperoxidase	MPO	0.1042
716	5-hydroxytryptamine 7 receptor	HTR7	0.1006
617	Muscarinic acetylcholine receptor M2	CHRM2	0.1001
563	Thyroid peroxidase	TPO	0.097
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0955
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0916
1729	Solute carrier family 22 member 6	SLC22A6	0.0891
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0861
6142	Solute carrier family 22 member 8	SLC22A8	0.0857
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0821
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0803
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0798
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0784
20	Prostaglandin G/H synthase 1	PTGS1	0.0771
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0751
3923	Cholinesterase	BCHE	0.0686
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0665
862	Multidrug resistance-associated protein 1	ABCC1	0.0646
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0636
6106	Cytochrome P450 2C18	CYP2C18	0.0618
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0613
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0606
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0586
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0548
1517	Beta-3 adrenergic receptor	ADRB3	0.0542
5455	Arylsulfatase A	ARSA	0.0518
146	Androgen receptor	AR	0.0502
1636	Trace amine-associated receptor 1	TAAR1	0.0499
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0492
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.049
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0481
3811	Cytochrome P450 19A1	CYP19A1	0.0479
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0459
465	Calmodulin	CALM1	0.045
1898	Cytochrome P450 1B1	CYP1B1	0.0435
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0435
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0435
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0433
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0425
828	Phenylalanine-4-hydroxylase	PAH	0.0424
3109	Phenylalanine-4-hydroxylase	phhA	0.0424
124	Histamine H2 receptor	HRH2	0.0417
776	Bile salt export pump	ABCB11	0.0415
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0382
6143	Solute carrier family 22 member 7	SLC22A7	0.0382
1024	Solute carrier family 22 member 11	SLC22A11	0.0381
290	Prostaglandin G/H synthase 2	PTGS2	0.0368
474	Acetylcholinesterase	ACHE	0.0366
477	DNA topoisomerase 4 subunit A	parC	0.0361
886	DNA topoisomerase 4 subunit A	parC	0.0361
6226	DNA topoisomerase 4 subunit A	parC	0.0361
404	DNA gyrase subunit A	gyrA	0.0356
6224	DNA gyrase subunit A	gyrA	0.0356
817	DNA topoisomerase 2-alpha	TOP2A	0.0354
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0346
2164	Multidrug resistance-associated protein 4	ABCC4	0.0334
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0317
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0314
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0312
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0311
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0306
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0304
136	Estrogen receptor	ESR1	0.0297
174	Sigma 1-type opioid receptor	SIGMAR1	0.029
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0272
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0269
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0264
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0262
36	Insulin receptor	INSR	0.0258
6010	Thiamine transporter 1	SLC19A2	0.0248
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0243
731	HIV-1 protease	HIV-1 protease	0.0243
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0242
2864	Penton protein	PIII	0.0236
164	Histamine H4 receptor	HRH4	0.0229
175	Thiamin pyrophosphokinase 1	TPK1	0.0222
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0221
1656	CYP2B protein	CYP2B	0.0219
6014	Cytochrome P450 2A13	CYP2A13	0.0219
6148	Multidrug resistance-associated protein 7	ABCC10	0.0215
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0214
6031	Cytochrome P450 3A43	CYP3A43	0.0209
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0209
5841	Insulin-like growth factor IB	IGF1	0.0206
380	Cytochrome P450 17A1	CYP17A1	0.0204
2472	Voltage-gated potassium channel	kcsA	0.0203
6366	Voltage-gated potassium channel	kcsA	0.0203
273	Apoptosis regulator Bcl-2	BCL2	0.0196
6070	Nischarin	NISCH	0.0196
6137	Multidrug resistance-associated protein 6	ABCC6	0.0195
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0195
847	Mu-type opioid receptor	OPRM1	0.0193
6141	Sodium/bile acid cotransporter	SLC10A1	0.0193
4203	Histamine N-methyltransferase	HNMT	0.0192
6136	Multidrug resistance-associated protein 5	ABCC5	0.0191
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0187
738	Monocarboxylate transporter 1	SLC16A1	0.0185
694	Matrix protein 2	M	0.0184
6151	Monocarboxylate transporter 10	SLC16A10	0.0181
5251	Carbonyl reductase [NADPH] 1	CBR1	0.018
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.018
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0178
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0178
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0177
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0177
624	Guanidinoacetate N-methyltransferase	GAMT	0.0175
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0172
159	Penicillin-binding protein 2B	penA	0.0171
6121	Penicillin-binding protein 2B	penA	0.0171
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0169
1341	Histamine H3 receptor	HRH3	0.0169
696	Kappa-type opioid receptor	OPRK1	0.0168
4773	Deoxycytidine kinase	DCK	0.0168
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0167
467	Delta-type opioid receptor	OPRD1	0.0167
3839	Phytanoyl-CoA dioxygenase, peroxisomal	PHYH	0.0165
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0162
5126	Arginase	rocF	0.0161
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.016
260	Cytochrome P450 51	ERG11	0.016
761	Cytochrome P450 51	ERG11	0.016
3163	Cytochrome P450 51	cyp51	0.016
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.016
161	Tubulin beta chain	TUBB	0.0158
312	Tubulin beta chain	TUB2	0.0158
5626	Nucleoside diphosphate kinase B	NME2	0.0156
3954	Egl nine homolog 2	EGLN2	0.0155
3948	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2	ALKBH2	0.0155
3956	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3	ALKBH3	0.0155
3946	Hypothetical protein DKFZp686H15154	OGFOD2	0.0155
189	Solute carrier family 23 member 1	SLC23A1	0.0155
3962	Egl nine homolog 3	EGLN3	0.0155
3935	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	PLOD2	0.0155
3966	Putative HIF-prolyl hydroxylase PH-4	P4HTM	0.0155
3953	2-oxoglutarate and iron-dependent oxygenase domain containing 1	OGFOD1	0.0155
3958	Jumonji/ARID domain-containing protein 1D	KDM5D	0.0155
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0154
869	Estrogen receptor beta	ESR2	0.0153
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0153
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0152
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0152
3947	Xanthine dehydrogenase/oxidase	XDH	0.0151
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.015
330	Spermidine synthase	SRM	0.0149
3038	Spermidine synthase	speE	0.0149
7	Nitric oxide synthase, inducible	NOS2	0.0149
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0147
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0145
756	Sex hormone-binding globulin	SHBG	0.0145
891	Dihydropteroate synthase	folP	0.0144
5359	Dihydropteroate synthase	folP	0.0144
7175	Dihydropteroate synthase	sulI	0.0144
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0143
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0138
122	P2Y purinoceptor 12	P2RY12	0.0138
468	Cytochrome P450 4A11	CYP4A11	0.0138
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0138
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0136
4120	NADPH--cytochrome P450 reductase	POR	0.0135
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0135
6432	Transporter	snf	0.0134
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0132
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0132
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0132
94	5-hydroxytryptamine 4 receptor	HTR4	0.013
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0129
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0129
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0128
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0126
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0126
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0126
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0126
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0126
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0126
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
5294	Nucleoside diphosphate kinase A	NME1	0.0125
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0123
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0122
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0122
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0122
411	Glycine N-methyltransferase	GNMT	0.0122
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.012
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.012
633	Penicillin-binding proteins 1A/1B	pbpA	0.012
3943	Peptidyl-glycine alpha-amidating monooxygenase	PAM	0.0119
358	Cystathionine beta-synthase	CBS	0.0118
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0118
3960	Egl nine homolog 1	EGLN1	0.0116
2300	Lysozyme	E	0.0115
3633	Lysozyme	R	0.0115
5597	Lysozyme	17	0.0115
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0115
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0114
6146	High affinity copper uptake protein 1	SLC31A1	0.0113
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.0113
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.0113
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.0113
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0113
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0112
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0112
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0112
70	Type-1 angiotensin II receptor	AGTR1	0.0111
571	Melatonin receptor type 1A	MTNR1A	0.011
362	Melatonin receptor type 1B	MTNR1B	0.011
373	Transthyretin	TTR	0.0108
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0108
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0107
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0106
5698	Riboflavin synthase alpha chain	ribE	0.0105
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0105
4604	Liver carboxylesterase 1	CES1	0.0104
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0103
737	Mineralocorticoid receptor	NR3C2	0.0103
408	Riboflavin kinase	RFK	0.0101
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0101
976	Platelet glycoprotein IX	GP9	0.0101
6220	Aryl hydrocarbon receptor	AHR	0.0101
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0099
921	Glutamate receptor 2	GRIA2	0.0098
6149	Solute carrier family 22 member 10	SLC22A10	0.0098
777	Tumor necrosis factor	TNF	0.0098
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0097
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
6182	Cytochrome P450 2J2	CYP2J2	0.0097
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0096
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0096
504	Mast/stem cell growth factor receptor	KIT	0.0094
1830	5'-nucleotidase	NT5E	0.0094
2485	Hyaluronate lyase	SP_0314	0.0093
3172	Hyaluronate lyase	hylB	0.0093
6847	Lactase-phlorizin hydrolase	LCT	0.0093
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0093
427	Substance-P receptor	TACR1	0.0093
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0092
2245	Xylose isomerase	xylA	0.0091
2253	Xylose isomerase	xylA	0.0091
2260	Xylose isomerase	xylA	0.0091
2431	Xylose isomerase	xylA	0.0091
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0091
6165	Copper-transporting ATPase 1	ATP7A	0.009
6163	Copper-transporting ATPase 2	ATP7B	0.009
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.009
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.009
3927	Choline transporter-like protein 3	SLC44A3	0.009
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.009
769	High-affinity choline transporter 1	SLC5A7	0.009
3926	Choline transporter-like protein 2	SLC44A2	0.009
861	Choline kinase alpha	CHKA	0.009
1686	Choline transporter-like protein 1	SLC44A1	0.009
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.009
700	Choline dehydrogenase, mitochondrial	CHDH	0.009
3925	Choline transporter-like protein 4	SLC44A4	0.009
576	Choline O-acetyltransferase	CHAT	0.009
3913	Glutamic acid decarboxylase	GAD65	0.009
3922	Phospholipase D2	PLD2	0.009
3924	Phospholipase D1	PLD1	0.009
5682	Ribonuclease pancreatic	RNASE1	0.0089
3809	Estrogen-related receptor gamma	ESRRG	0.0087
908	Glutathione S-transferase theta-1	GSTT1	0.0087
844	Epidermal growth factor receptor	EGFR	0.0087
592	Carbonic anhydrase 4	CA4	0.0085
904	Glutathione S-transferase P	GSTP1	0.0085
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0085
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0085
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0085
1483	Membrane copper amine oxidase	AOC3	0.0085
16	Adenosine A1 receptor	ADORA1	0.0084
357	Carbonic anhydrase 2	CA2	0.0084
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0083
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0083
1	Peptidoglycan synthetase ftsI	ftsI	0.0083
4155	Peptidoglycan synthetase ftsI	ftsI	0.0083
527	Prostacyclin receptor	PTGIR	0.0082
6167	Organic solute transporter subunit beta	OSTB	0.0081
6166	Organic solute transporter subunit alpha	OSTA	0.0081
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0081
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0081
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0081
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0081
614	Progesterone receptor	PGR	0.0081
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0081
1178	Adenosine A2a receptor	ADORA2A	0.008
228	Beta platelet-derived growth factor receptor	PDGFRB	0.008
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
3611	Cytidine deaminase	cdd	0.008
3707	Cytidine deaminase	cdd	0.008
4211	Cytidine deaminase	CDA	0.008
295	Carbonic anhydrase 1	CA1	0.0079
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
867	Penicillin-binding protein 3	pbpC	0.0077
6119	Penicillin-binding protein 3	pbp3	0.0077
7154	Penicillin-binding protein 3	pbp3	0.0077
7157	Penicillin-binding protein 3	LMHCC_2184	0.0077
7162	Penicillin-binding protein 3	pbpB	0.0077
7172	Penicillin-binding protein 3	pbp3	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0076
654	Flavin reductase	BLVRB	0.0075
125	DNA polymerase beta	POLB	0.0074
923	Glutamate receptor 3	GRIA3	0.0074
338	DNA polymerase	UL30	0.0073
379	DNA polymerase	UL54	0.0073
697	DNA polymerase	ORF28	0.0073
2482	DNA polymerase	43	0.0073
4104	DNA polymerase	BALF5	0.0073
6085	Fatty acid-binding protein, intestinal	FABP2	0.0073
6126	Carbonic anhydrase 7	CA7	0.0073
735	Alanine aminotransferase 1	GPT	0.0073
3904	Alanine aminotransferase 2	GPT2	0.0073
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0073
645	Penicillin-binding protein 1A	mrcA	0.0073
5805	Penicillin-binding protein 1A	ponA	0.0073
6185	Penicillin-binding protein 1A	mrcA	0.0073
6799	Penicillin-binding protein 1A	pbpA	0.0073
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0072
896	Glutathione S-transferase Mu 1	GSTM1	0.0072
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0072
702	UMP-CMP kinase	CMPK1	0.0072
6138	Multidrug resistance protein 3	ABCB4	0.0071
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0071
365	Dihydrofolate reductase	DHFR	0.007
2381	Dihydrofolate reductase	DFR1	0.007
2833	Dihydrofolate reductase	Not Available	0.007
2931	Dihydrofolate reductase	folA	0.007
3544	Dihydrofolate reductase	folA	0.007
3682	Dihydrofolate reductase	folA	0.007
6642	Dihydrofolate reductase	folA	0.007
6756	Dihydrofolate reductase	dfrA	0.007
6171	Solute carrier family 28 member 3	SLC28A3	0.007
49	Endothelin B receptor	EDNRB	0.007
6102	Arylamine N-acetyltransferase 2	NAT2	0.007
3426	Glutamine synthetase	glnA	0.0069
3987	Glutamine synthetase	GLUL	0.0069
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
1618	High affinity nerve growth factor receptor	NTRK1	0.0067
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0067
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0066
578	Endothelin-1 receptor	EDNRA	0.0066
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0066
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0066
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0066
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0066
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0066
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0066
407	Vascular endothelial growth factor receptor 2	KDR	0.0065
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0065
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0065
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0065
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0065
860	Nicotinamide N-methyltransferase	NNMT	0.0064
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0064
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
699	Nicotinic acid receptor 1	GPR109A	0.0064
928	Nicotinic acid receptor 2	GPR109B	0.0064
2539	Tubulin alpha-1 chain	TUBA4A	0.0064
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0063
173	Toll-like receptor 7	TLR7	0.0063
133	Dihydropterate synthase	sulI	0.0063
565	Extracellular calcium-sensing receptor	CASR	0.0062
1629	Transcription factor AP-1	JUN	0.0062
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0062
4116	Dihydropteroate synthetase	Not Available	0.0062
26	Vascular endothelial growth factor receptor 3	FLT4	0.0061
558	Solute carrier family 12 member 1	SLC12A1	0.0061
1010	Cytochrome P450 51A1	CYP51A1	0.0061
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.006
751	Potassium channel subfamily K member 6	KCNK6	0.006
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.006
332	Beta-lactamase	blaZ	0.0059
2478	Beta-lactamase	ampC	0.0059
2613	Beta-lactamase	ampC	0.0059
2635	Beta-lactamase	ampC	0.0059
2700	Beta-lactamase	penP	0.0059
5445	Beta-lactamase	blaB	0.0059
6019	Beta-lactamase	SHV-7	0.0059
6701	Beta-lactamase	cphA	0.0059
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0059
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0058
32	Vascular endothelial growth factor receptor 1	FLT1	0.0058
183	Vascular endothelial growth factor A	VEGFA	0.0058
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0058
6067	Penicillin binding protein 2a	mecA	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
29	Tubulin beta-1 chain	TUBB1	0.0058
6218	Pannexin-1	PANX1	0.0058
4122	Histone deacetylase 2	HDAC2	0.0057
788	Creatine kinase M-type	CKM	0.0057
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0056
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0056
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0056
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0055
1864	RET proto-oncogene	RET	0.0055
6859	Protein S100-A4	S100A4	0.0055
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0055
1770	Phospholipase C	PLCL1	0.0055
2841	Phospholipase C	plc	0.0055
172	Potassium channel subfamily K member 1	KCNK1	0.0055
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0055
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0055
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0055
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0055
871	Glucocorticoid receptor	NR3C1	0.0054
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0053
714	Glutathione reductase, mitochondrial	GSR	0.0052
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0052
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0052
811	Translocator protein	TSPO	0.0052
482	Glycine receptor subunit alpha-1	GLRA1	0.005
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0049
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0049
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0049
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0048
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0046
518	Peroxidase/catalase T	katG	0.0046
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0046
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0046
6044	Serum paraoxonase/lactonase 3	PON3	0.0046
275	Arachidonate 5-lipoxygenase	ALOX5	0.0046
1275	Estrogen sulfotransferase	SULT1E1	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0045
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0044
6020	Aldehyde oxidase	AOX1	0.0044
2112	Toll-like receptor 9	TLR9	0.0044
818	50S ribosomal protein L10	rplJ	0.0043
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
6133	Sodium channel subunit beta-2	SCN2B	0.0043
6134	Sodium channel subunit beta-3	SCN3B	0.0043
6132	Sodium channel subunit beta-1	SCN1B	0.0043
6135	Sodium channel subunit beta-4	SCN4B	0.0043
6127	Carbonic anhydrase-related protein	CA8	0.0043
6129	Carbonic anhydrase-related protein 11	CA11	0.0043
6128	Carbonic anhydrase-related protein 10	CA10	0.0043
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0043
823	Fibroblast growth factor receptor 2	FGFR2	0.0042
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0042
2449	Tubulin alpha-3 chain	TUBA1A	0.0041
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0041
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0041
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0041
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0041
123	Diamine acetyltransferase 1	SAT1	0.004
634	Squalene monooxygenase	SQLE	0.004
7196	Squalene monooxygenase	ERG1	0.004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.004
33	Cystine/glutamate transporter	SLC7A11	0.004
6130	Carbonic anhydrase 13	CA13	0.004
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.004
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.004
500	Monocarboxylate transporter 4	SLC16A3	0.004
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0039
4217	Telomerase reverse transcriptase	TERT	0.0039
6212	Tubulin gamma-1 chain	TUBG1	0.0039
6210	Tubulin delta chain	TUBD1	0.0039
6211	Tubulin epsilon chain	TUBE1	0.0039
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0038
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0037
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0037
130	Prostacyclin synthase	PTGIS	0.0037
6131	Carbonic anhydrase 14	CA14	0.0036
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0036
489	Monocarboxylate transporter 2	SLC16A7	0.0036
723	Cytosolic phospholipase A2	PLA2G4A	0.0036
4228	Keratin, type II cytoskeletal 7	KRT7	0.0036
4311	tRNA	TRDMT1	0.0036
4325	tRNA	trmD	0.0036
4328	tRNA	trmD	0.0036
1074	Urokinase-type plasminogen activator	PLAU	0.0036
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
6122	Carbonic anhydrase 3	CA3	0.0034
712	Tubulin alpha chain	TUB1	0.0034
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0034
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0034
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0033
6506	Stathmin-4	STMN4	0.0033
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
327	Glutathione reductase	gor	0.0033
5110	Glutathione reductase	GR2	0.0033
499	Arginine decarboxylase	ADC	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
1648	Elastin	ELN	0.0032
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0032
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0032
1039	Histone deacetylase 9	HDAC9	0.0032
1192	Sulfotransferase 1A1	SULT1A1	0.0032
459	Retinoic acid receptor RXR-alpha	RXRA	0.0032
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
291	Nitric-oxide synthase, endothelial	NOS3	0.0031
6168	Solute carrier family 22 member 16	SLC22A16	0.0031
4205	Carbonic anhydrase 9	CA9	0.0031
3007	Carbonic anhydrase 12	CA12	0.0031
24	Thymidylate synthase	TMP1	0.0031
359	Thymidylate synthase	TYMS	0.0031
2626	Thymidylate synthase	thyA	0.0031
2729	Thymidylate synthase	thyA	0.0031
5352	Thymidylate synthase	THYA	0.0031
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0031
577	Argininosuccinate lyase	ASL	0.0031
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0031
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0031
834	Arginase-2, mitochondrial	ARG2	0.0031
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
780	Retinoic acid receptor RXR-gamma	RXRG	0.003
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.003
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
3957	Adenosine deaminase	ADA	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
150	Cationic amino acid transporter 3	SLC7A3	0.003
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.003
58	Cationic amino acid transporter 4	SLC7A4	0.003
2320	Thymidine kinase, cytosolic	TK1	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.003
4192	DNA topoisomerase 2-beta	TOP2B	0.0029
54	Prothrombin	F2	0.0029
4103	Proteasome subunit beta type 2	PSMB2	0.0029
4102	Proteasome subunit beta type 5	PSMB5	0.0029
4101	Proteasome subunit beta type 1	PSMB1	0.0029
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0029
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0029
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0028
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0028
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0028
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0028
740	Argininosuccinate synthase	ASS1	0.0028
865	Argininosuccinate synthase	ASS1	0.0028
2680	Argininosuccinate synthase	argG	0.0028
3194	Argininosuccinate synthase	argG	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
88	Retinoic acid receptor RXR-beta	RXRB	0.0027
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0027
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
284	DNA-directed RNA polymerase beta chain	rpoB	0.0027
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0027
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0027
551	Carnitine O-acetyltransferase	CRAT	0.0027
952	Dipeptidyl peptidase 4	DPP4	0.0026
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0026
85	Growth hormone receptor	GHR	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0025
3830	Calreticulin	CALR	0.0025
1541	Metalloproteinase	mmp20	0.0025
581	Cytochrome P450 2R1	CYP2R1	0.0025
239	Coagulation factor X	F10	0.0024
1050	Bile salt sulfotransferase	SULT2A1	0.0024
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0024
106	Cannabinoid receptor 2	CNR2	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0024
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0024
6174	50S ribosomal protein L32	rpmF	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
1196	Complement decay-accelerating factor	CD55	0.0023
1992	Vitamin D-binding protein	GC	0.0023
65	Matrix metalloproteinase-9	Not Available	0.0023
319	Opioid receptor, sigma 1	OPRS1	0.0023
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0023
68	Cannabinoid receptor 1	CNR1	0.0022
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
1630	Integrin beta-2	ITGB2	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
165	FL cytokine receptor	FLT3	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
5300	Antigen peptide transporter 1	TAP1	0.0021
1374	Natriuretic peptides B	NPPB	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
1827	Gap junction alpha-1 protein	GJA1	0.0021
1908	Vascular cell adhesion protein 1	VCAM1	0.0021
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.002
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.002
251	Alcohol dehydrogenase 1A	ADH1A	0.002
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.002
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.002
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.002
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.002
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.002
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.002
2808	Chloramphenicol acetyltransferase 3	cat3	0.002
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.002
1820	Beta-nerve growth factor	NGF	0.002
814	Ryanodine receptor 1	RYR1	0.002
5934	Cytochrome P450 26A1	CYP26A1	0.0019
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
6043	Putative G-protein coupled receptor 44	GPR44	0.0019
820	Glycine receptor subunit alpha-2	GLRA2	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
3808	Dihydropteroate synthase 2	folP2	0.0019
3601	Dihydropteroate synthase 1	folP1	0.0019
3807	Dihydropteroate synthase 1	folP1	0.0019
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0019
2417	Chloramphenicol acetyltransferase	cat	0.0018
3278	Chloramphenicol acetyltransferase	cat	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
705	Glutamate receptor 1	GRIA1	0.0018
1253	Interferon gamma	IFNG	0.0018
2810	Dr hemagglutinin structural subunit	draA	0.0018
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0018
444	Alcohol dehydrogenase 1B	ADH1B	0.0018
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0018
3937	Fatty-acid amide hydrolase	FAAH	0.0018
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0018
4486	Phenol 2-hydroxylase component B	pheA2	0.0018
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0018
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0018
5117	Dihydrolipoyl dehydrogenase	lpd	0.0018
4439	Ferredoxin reductase	bphA4	0.0018
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0018
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0018
526	Thioredoxin reductase	trxB	0.0018
3767	Thioredoxin reductase	trxB	0.0018
5122	Mersacidin decarboxylase	mrsD	0.0017
5095	Putidaredoxin reductase	camA	0.0017
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0017
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0017
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0017
5109	Outer membrane protein p64k or PM-6	m-6	0.0017
5115	FkbI	fkbI	0.0017
3133	UDP-galactopyranose mutase	glf	0.0017
5099	UDP-galactopyranose mutase	glf	0.0017
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0017
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0017
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0017
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0017
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0017
5111	Phenylacetone monooxygenase	pamO	0.0017
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0017
5083	Cryptochrome DASH	cry	0.0017
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0017
5081	L-aspartate oxidase	nadB	0.0017
1410	Oxidoreductase	HSD17B6	0.0017
4725	Oxidoreductase	Not Available	0.0017
5124	Oxidoreductase	Not Available	0.0017
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0017
268	Adenosine A2b receptor	ADORA2B	0.0017
84	Nuclear receptor 0B1	NR0B1	0.0017
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0017
856	Vitamin D3 receptor	VDR	0.0017
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0016
572	Integrin alpha-L	ITGAL	0.0016
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0016
3102	Flavohemoprotein	hmp	0.0016
4969	Flavohemoprotein	hmp	0.0016
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0016
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0016
1243	Cathepsin D	CTSD	0.0016
517	Alcohol dehydrogenase 1C	ADH1C	0.0016
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
4440	NADH peroxidase	npr	0.0015
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0015
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0015
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0015
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0015
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0015
5072	N,N-dimethylglycine oxidase	dmg	0.0015
2470	Pyruvate oxidase	pox5	0.0015
5073	Ferredoxin--NADP reductase	petH	0.0015
5076	Ferredoxin--NADP reductase	fpr	0.0015
5119	Ferredoxin--NADP reductase	petH	0.0015
5121	Ferredoxin--NADP reductase	fpr	0.0015
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0015
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0015
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0015
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0015
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0015
2268	Cholesterol oxidase	choB	0.0015
2822	Cholesterol oxidase	choA	0.0015
2526	NADPH-ferredoxin reductase fprA	fprA	0.0015
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0015
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
2207	Rhodopsin	RHO	0.0015
6689	TraN protein	traN	0.0015
6672	Destrin	DSTN	0.0015
6680	Cofilin-1	CFL1	0.0015
6670	Ig kappa chain V-I region Bi	Not Available	0.0015
6671	Ig heavy chain V-III region VH26	Not Available	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
6688	TraF protein	traF	0.0015
6404	Rhomboid protease glpG	glpG	0.0015
6797	Rhomboid protease glpG	glpG	0.0015
3710	Acyl-CoA thioesterase 2	tesB	0.0015
6685	Outer membrane protein II	porB	0.0015
6690	BenF-like porin	PFL_1329	0.0015
6681	Probable N-acetylneuraminic acid outer membrane channel protein nanC	nanC	0.0015
6687	TraO protein	traO	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
6668	Cytochrome c oxidase subunit 1-beta	ctaDII	0.0015
6679	Colicin-Ia	cia	0.0015
6676	Fe(3+)-pyochelin receptor	fptA	0.0015
6674	Nuclear factor erythroid 2-related factor 1	NFE2L1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0015
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0015
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0015
3086	Plasmepsin-2	Not Available	0.0014
126	D-lactate dehydrogenase	dld	0.0014
3545	D-lactate dehydrogenase	Not Available	0.0014
4510	D-lactate dehydrogenase	ldhA	0.0014
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0014
4226	Uridine phosphorylase 2	UPP2	0.0014
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.0014
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0014
2893	Glycine oxidase	thiO	0.0014
2091	Endoplasmin	HSP90B1	0.0014
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0014
2232	Interleukin-5	IL5	0.0014
1593	Mucin-2	MUC2	0.0014
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0013
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0013
3404	Exotoxin A	eta	0.0013
2567	Thymidylate synthase thyX	thyX	0.0013
2823	Trypanothione reductase	TPR	0.0013
2769	P-hydroxybenzoate hydroxylase	pobA	0.0013
2809	P-hydroxybenzoate hydroxylase	pobA	0.0013
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0013
5787	Angiopoietin-1 receptor	TEK	0.0013
4760	Mll3241 protein	mll3241	0.0013
3395	Iron(III) dicitrate transport protein fecA	fecA	0.0013
6385	H subunit of photosynthetic reaction center complex	puhA	0.0013
6474	Outer membrane protein W	ompW	0.0013
6678	Colicin I receptor	cirA	0.0013
3578	Protein crcA	crcA	0.0013
6675	Colicin-E3	ceaC	0.0013
2925	Long-chain fatty acid transport protein	fadL	0.0013
6480	Outer membrane usher protein papC	papC	0.0013
6438	Outer membrane protein G	ompG	0.0013
2447	Ammonia channel	amtB	0.0013
4225	Uridine phosphorylase 1	UPP1	0.0013
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0013
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0013
6103	Arylamine N-acetyltransferase 1	NAT1	0.0013
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0012
2021	Thrombomodulin	THBD	0.0012
76	Nitric-oxide synthase, brain	NOS1	0.0012
232	Corticosteroid-binding globulin	SERPINA6	0.0012
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0012
2380	Monomeric sarcosine oxidase	soxA	0.0012
413	Amidophosphoribosyltransferase	PPAT	0.0012
2515	Amidophosphoribosyltransferase	purF	0.0012
3714	Amidophosphoribosyltransferase	purF	0.0012
6645	D-amino-acid oxidase	DAO	0.0012
3587	Gastrotropin	FABP6	0.0012
162	Retinoic acid receptor gamma-1	RARG	0.0012
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0012
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0012
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0012
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0012
6524	Protein tonB	tonB	0.0012
2679	Vitamin B12 transporter btuB	btuB	0.0012
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0012
473	L-lactate dehydrogenase A chain	LDHA	0.0011
6048	Troponin C, skeletal muscle	TNNC2	0.0011
5798	Mitogen-activated protein kinase 11	MAPK11	0.0011
469	Annexin A1	ANXA1	0.0011
267	Plasminogen activator inhibitor 1	SERPINE1	0.0011
6677	Myelin P2 protein	PMP2	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0011
2290	ADP-ribosyl cyclase 2	BST1	0.001
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
4237	50S ribosomal protein L22	rplV	0.001
1714	Mitogen-activated protein kinase 3	MAPK3	0.001
6221	Steroid hormone receptor ERR1	ESRRA	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
144	Hemoglobin subunit alpha	HBA1	0.001
6352	Reaction center protein H chain	puhA	0.001
6456	Reaction center protein H chain	puhA	0.001
6682	Reaction center protein H chain	puhA	0.001
6353	Reaction center protein L chain	pufL	0.001
6454	Reaction center protein L chain	pufL	0.001
6683	Reaction center protein L chain	pufL	0.001
6354	Reaction center protein M chain	pufM	0.001
6455	Reaction center protein M chain	pufM	0.001
6684	Reaction center protein M chain	pufM	0.001
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.001
760	Fibroblast growth factor 1	FGF1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
2828	Squalene--hopene cyclase	shc	0.0009
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0009
1268	Neuropeptide S receptor	NPSR1	0.0009
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0009
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
6042	Prostaglandin reductase 2	PTGR2	0.0009
1262	Corticotropin-lipotropin	POMC	0.0008
1792	Tissue-type plasminogen activator	PLAT	0.0008
2236	Casein kinase II subunit alpha	CSNK2A1	0.0008
3932	Glutathione S-transferase A2	GSTA2	0.0008
6073	Potassium channel subfamily K member 9	KCNK9	0.0008
6072	Potassium channel subfamily K member 3	KCNK3	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
244	Angiotensin-converting enzyme	ACE	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
4948	Cytochrome c-553	Not Available	0.0007
4923	Cytochrome c3	DvMF_2499	0.0007
4945	Cytochrome c3	Not Available	0.0007
4949	Cytochrome c3	DVU_3171	0.0007
4968	Cytochrome c3	cytc3	0.0007
4997	Cytochrome c3	SO_2727	0.0007
5219	Cytochrome c3	cyd	0.0007
4902	Nine-heme cytochrome c	Ddes_2038	0.0007
3189	High-molecular-weight cytochrome c	hmcA	0.0007
822	Aldose reductase	AKR1B1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
1313	Lactoylglutathione lyase	GLO1	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
4386	Hemoglobin-like protein HbN	glbN	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
719	Retinoic acid receptor responder protein 1	RARRES1	0.0006
770	Retinoic acid-induced protein 3	GPRC5A	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
3221	Cytochrome c4	cc4	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
5924	Microtubule-associated protein 4	MAP4	0.0005
5923	Microtubule-associated protein tau	MAPT	0.0005
798	Osteocalcin	BGLAP	0.0005
569	Retinal dehydrogenase 2	ALDH1A2	0.0005
1852	Microtubule-associated protein 2	MAP2	0.0005
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0005
611	Retinal dehydrogenase 1	ALDH1A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1507	Cytochrome c	CYCS	0.0005
369	Coagulation factor VII	F7	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
6824	Tyrosine-protein kinase Lyn	LYN	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0003
4954	Soluble cytochrome b558	Not Available	0.0002
4916	Cyanoglobin	glbN	0.0002
4934	Cytochrome c-551	nirM	0.0002
5218	Cytochrome c-551	nirM	0.0002
4947	Bacterial hemoglobin	vhb	0.0002
4915	Cytochrome c-550	psbV	0.0002
4959	Cytochrome c-550	psbV	0.0002
5216	Cytochrome c-550	psbV	0.0002
4925	Cytochrome c-type protein SHP	shp	0.0002
4998	Hemoglobin-like protein yjbI	yjbI	0.0002
4905	Cytochrome c2	Not Available	0.0002
4939	Cytochrome c2	cycA	0.0002
4964	Cytochrome c2	cycA	0.0002
4979	Cytochrome c2	cycA	0.0002
6673	Cytochrome c2	cycA	0.0002
5000	HemO	hemO	0.0002
4975	Cytochrome c-556	RPA3973	0.0002
4984	Neuroglobin	NGB	0.0002
4943	Cytochrome c6	petJ	0.0002
4910	Cytoglobin	CYGB	0.0002
4907	Cytochrome c-L	moxG	0.0002
6865	Cytochrome c-L	moxG	0.0002
4981	Iron-starvation protein PigA	pigA	0.0002
4971	Nonaheme cytochrome c	hmcA	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0002
4909	CooA protein	cooA	0.0002
4994	Hemoglobin-like protein HbO	glbO	0.0002
4935	Cytochrome c-554	cycA1	0.0002
644	Heme oxygenase 2	HMOX2	0.0002
4982	Heme oxygenase 2	pbsA2	0.0002
4942	Diheme cytochrome c napB	napB	0.0002
3116	Bacterioferritin	bfr	0.0002
4906	Bacterioferritin	bfr	0.0002
4965	Bacterioferritin	bfr	0.0002
4922	Cytochrome c, putative	SO_4144	0.0002
4764	Cytochrome P450 165C4	CYP165C4	0.0002
4937	Cytochrome oxidase subunit II	rcoxA	0.0002
4989	Cytochrome c551 peroxidase	ccp	0.0002
5222	Cytochrome c551 peroxidase	ccpA	0.0002
4961	Hemophore HasA	hasA	0.0002
4976	Apocytochrome f	petA	0.0002
6407	Apocytochrome f	petA	0.0002
4904	Cytochrome c family protein	GSU1996	0.0002
4903	Methyl-accepting chemotaxis protein	Tar4	0.0002
4999	Cytochrome P450 165B3	CYP165B3	0.0002
4960	Putative cytochrome P450-family protein	SCO7417	0.0002
4931	Cytochrome P450 167A1	CYP167A1	0.0002
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0002
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0002
4993	Hydroxylamine oxidoreductase	hao1	0.0002
4972	P450cin	cinA	0.0002
3093	Catalase HPII	katE	0.0002
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0002
4952	Catalase/peroxidase	katA	0.0002
4920	Peroxidase/catalase	katG	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
4990	PpcA	ppcA	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001
2298	Cytochrome P450-cam	camC	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00988 - Dopamine

Targets

Enzymes

Transporters

Predictions