DT-Web: DB00458

Identification

Name

Imipramine

Accession Number

DB00458 (APRD00672, DB08002)

Type

small molecule

Description

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Imipramine has less sedative and anticholinergic effects than the tertiary amine TCAs, amitriptyline and clomipramine. See toxicity section below for a complete listing of side effects. Imipramine may be used to treat depression and nocturnal enuresis in children. Unlabeled indications include chronic and neuropathic pain (including diabetic neuropathy), panic disorder, attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

280.4073

Groups

approved

Monoisotopic Weight

280.193948778

Pharmacology

Indication

For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older. May also be used to manage panic disorders, with or without agoraphobia, as a second line agent in ADHD, management of eating disorders, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, and for symptomatic treatment of postherpetic neuralgia.

Mechanism of action

Imipramine works by inhibiting the neuronal reuptake of the neurotransmitters norepinephrine and serotonin. It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter preventing or reducing the reuptake of norepinephrine and serotonin by nerve cells. Depression has been linked to a lack of stimulation of the post-synaptic neuron by norepinephrine and serotonin. Slowing the reuptake of these neurotransmitters increases their concentration in the synaptic cleft, which is thought to contribute to relieving symptoms of depression. In addition to acutely inhibiting neurotransmitter re-uptake, imipramine causes down-regulation of cerebral cortical beta-adrenergic receptors and sensitization of post-synaptic serotonergic receptors with chronic use. This leads to enhanced serotonergic transmission.

Absorption

Rapidly and well absorbed after oral administration. Bioavailability is approximately 43%. Peak plasma concentrations usually attained 1 - 2 hours following oral administration. Absorption is unaffected by food.

Protein binding

60-95%

Biotransformation

Exclusively metabolized by the liver. Imipramine is converted in the liver by various CYP isoenzymes (e.g. CYP1A2, CYP2D6, CYP3A4, CYP2C9) to active metabolites desipramine and 2-hydroxydesipramine.

Route of elimination

Approximately 40% of an orally administered dose is eliminated in urine within 24 hours, 70% in 72 hours. Small amounts are eliminated in feces via the biliary elimination.

Toxicity

Oral, rat LD₅₀: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death. Antagonism of the histamine H₁ and α₁ receptors can lead to sedation and hypotension. Antimuscarinic and anticholinergic side effects such as blurred vision, dry mouth, constipation and urine retention may occur. Cardiotoxicity may occur with high doses of imipramine. Cardiovascular side effects in postural hypotension, tachycardia, hypertension, ECG changes and congestive heart failure. Psychotoxic effects include impaired memory and delirium. Induction of hypomanic or manic episodes may occur in patients with a history of bipolar disorder. Withdrawal symptoms include GI disturbances (e.g. nausea, vomiting, abdominal pain, diarrhea), anxiety, insomnia, nervousness, headache and malaise.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Altretamine	Risk of severe hypotension
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir	Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if atazanavir if initiated, discontinued or dose changed.
Butabarbital	Barbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like imipramine. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Butalbital	Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants such as imipramine. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Carbamazepine	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, imipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if carbamazepine is initiated, discontinued or dose changed.
Cimetidine	Cimetidine may increase the effect of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if cimetidine is initiated, discontinued or dose changed.
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Clonidine	The tricyclic antidepressant, imipramine, decreases the effect of clonidine.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroquinidine barbiturate	Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, imipramine.
Dobutamine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of dobutamine.
Donepezil	Possible antagonism of action
Dopamine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of dopamine.
Duloxetine	Possible increase in the levels of this agent when used with duloxetine
Ephedra	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of ephedra.
Ephedrine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of ephedrine.
Epinephrine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of epinephrine.
Fenoterol	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of fenoterol.
Fluconazole	Fluconazole may increase the effect and toxicity of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Additive QTc-prolonging effects may also occur. Monitor for changes in the therapeutic and adverse effects of imipramine if fluconazole is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Fluoxetine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of imipramine if fluoxetine is initiated, discontinued or dose changed.
Fluvoxamine	The SSRI, fluvoxamine, may increase the serum concentration of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of imipramine if fluvoxamine is initiated, discontinued or dose changed.
Galantamine	Possible antagonism of action
Grepafloxacin	Increased risk of cardiotoxicity and arrhythmias
Guanethidine	The tricyclic antidepressant, imipramine, may increase the sympathomimetic effect of guanethidine.
Iobenguane	May diminish the therapeutic effect and increase chances of producing a false negative imaging result of Iobenguane as it inhibits noradrenaline transporter function
Isocarboxazid	Possibility of severe adverse effects
Isoproterenol	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of isoproterenol.
Ketoconazole	Ketoconazole, a moderate CYP2D6 inhibitor, may increase the serum concentration of imipramine by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if ketoconazole is initiated, discontinued or dose changed.
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mephentermine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of mephentermine.
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Metaraminol	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of metaraminol.
Methoxamine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of methoxamine.
Moclobemide	Possible severe adverse reaction with this combination
Norepinephrine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of norepinephrine.
Orciprenaline	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of orciprenaline.
Phenelzine	Possibility of severe adverse effects
Phenylephrine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of phenylephrine.
Phenylpropanolamine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of phenylpropanolamine.
Pirbuterol	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of pirbuterol.
Procaterol	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of procaterol.
Pseudoephedrine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of pseudoephedrine.
Quinidine	Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Quinidine barbiturate	Quinidine barbiturate increases the effect of tricyclic antidepressant, imipramine.
Rasagiline	Possibility of severe adverse effects
Rifabutin	The rifamycin, rifabutin, may decrease the effect of the tricyclic antidepressant, imipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if rifabutin is initiated, discontinued or dose changed.
Rifampin	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, imipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if rifampin is initiated, discontinued or dose changed.
Ritonavir	Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if ritonavir if initiated, discontinued or dose changed.
Rivastigmine	Possible antagonism of action
Salbutamol	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of salbutamol.
Sibutramine	Increased risk of CNS adverse effects
Sparfloxacin	Increased risk of cardiotoxicity and arrhythmias
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Imipramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tamoxifen	Imipramine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Imipramine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Imipramine is initiated, discontinued, or dose changed.
Terbinafine	Terbinafine may increase the effect and toxicity of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if terbinafine is initiated, discontinued or dose changed.
Terbutaline	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of terbutaline.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Ticlopidine	Ticlopidine may decrease the metabolism and clearance of Imipramine. Consider alternate therapy or monitor for adverse/toxic effects of Imipramine if Ticlopidine is initiated, discontinued or dose changed.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	Tramadol increases the risk of serotonin syndrome and seizures. Imipramine may decrease the effect of Tramadol by decreasing active metabolite production.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimethobenzamide	Trimethobenzamide and Imipramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome. QTc-prolongation may also occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine	Triprolidine and Imipramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Imipramine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and imipramine, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Do not take fibers at the same time.
Take with food.
Avoid excessive quantities of coffee or tea (Caffeine).
Avoid St.John's Wort.
Avoid alcohol.

Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Mitchell HA, Ahern TH, Liles LC, Javors MA, Weinshenker D: The effects of norepinephrine transporter inactivation on locomotor activity in mice. Biol Psychiatry. 2006 Nov 15;60(10):1046-52. Epub 2006 Aug 7. - Pubmed Dziedzicka-Wasylewska M, Faron-Gorecka A, Kusmider M, Drozdowska E, Rogoz Z, Siwanowicz J, Caron MG, Bonisch H: Effect of antidepressant drugs in mice lacking the norepinephrine transporter. Neuropsychopharmacology. 2006 Nov;31(11):2424-32. Epub 2006 Mar 22. - Pubmed Anton M, Wagner B, Haubner R, Bodenstein C, Essien BE, Bonisch H, Schwaiger M, Gansbacher B, Weber WA: Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells. J Gene Med. 2004 Jan;6(1):119-26. - Pubmed Kantor L, Hewlett GH, Park YH, Richardson-Burns SM, Mellon MJ, Gnegy ME: Protein kinase C and intracellular calcium are required for amphetamine-mediated dopamine release via the norepinephrine transporter in undifferentiated PC12 cells. J Pharmacol Exp Ther. 2001 Jun;297(3):1016-24. - Pubmed Tatsumi M, Jansen K, Blakely RD, Richelson E: Pharmacological profile of neuroleptics at human monoamine transporters. Eur J Pharmacol. 1999 Mar 5;368(2-3):277-83. - Pubmed
DTHybrid score	0.7239
Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Leboyer M, Quintin P, Manivet P, Varoquaux O, Allilaire JF, Launay JM: Decreased serotonin transporter binding in unaffected relatives of manic depressive patients. Biol Psychiatry. 1999 Dec 15;46(12):1703-6. - Pubmed Scholze P, Zwach J, Kattinger A, Pifl C, Singer EA, Sitte HH: Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter. J Pharmacol Exp Ther. 2000 Jun;293(3):870-8. - Pubmed Quintin P, Benkelfat C, Launay JM, Arnulf I, Pointereau-Bellenger A, Barbault S, Alvarez JC, Varoquaux O, Perez-Diaz F, Jouvent R, Leboyer M: Clinical and neurochemical effect of acute tryptophan depletion in unaffected relatives of patients with bipolar affective disorder. Biol Psychiatry. 2001 Aug 1;50(3):184-90. - Pubmed Goulet M, Miller GM, Bendor J, Liu S, Meltzer PC, Madras BK: Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse. 2001 Dec 1;42(3):129-40. - Pubmed Barkan T, Gurwitz D, Levy G, Weizman A, Rehavi M: Biochemical and pharmacological characterization of the serotonin transporter in human peripheral blood lymphocytes. Eur Neuropsychopharmacol. 2004 May;14(3):237-43. - Pubmed Schloss P, Betz H: Heterogeneity of antidepressant binding sites on the recombinant rat serotonin transporter SERT1. Biochemistry. 1995 Oct 3;34(39):12590-5. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score	0.5879
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.5129
Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.8772
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS: The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. Epub 2010 Apr 2. - Pubmed
DTHybrid score	0.7094
Alpha-1D adrenergic receptor
Name	Alpha-1D adrenergic receptor
Gene Name	ADRA1D
Pharmacological action	no
Actions	antagonist
References	Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS: The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. Epub 2010 Apr 2. - Pubmed
DTHybrid score	0.3674
Muscarinic acetylcholine receptor M1
Name	Muscarinic acetylcholine receptor M1
Gene Name	CHRM1
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	1.1275
Muscarinic acetylcholine receptor M2
Name	Muscarinic acetylcholine receptor M2
Gene Name	CHRM2
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.9789
Muscarinic acetylcholine receptor M3
Name	Muscarinic acetylcholine receptor M3
Gene Name	CHRM3
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.981
Muscarinic acetylcholine receptor M4
Name	Muscarinic acetylcholine receptor M4
Gene Name	CHRM4
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.7011
Muscarinic acetylcholine receptor M5
Name	Muscarinic acetylcholine receptor M5
Gene Name	CHRM5
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.6051
Potassium voltage-gated channel subfamily D member 2
Name	Potassium voltage-gated channel subfamily D member 2
Gene Name	KCND2
Pharmacological action	no
Actions	inhibitor
References	Casis O, Sanchez-Chapula JA: Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel. J Cardiovasc Pharmacol. 1998 Oct;32(4):521-6. - Pubmed
DTHybrid score	0.3937
Potassium voltage-gated channel subfamily D member 3
Name	Potassium voltage-gated channel subfamily D member 3
Gene Name	KCND3
Pharmacological action	no
Actions	inhibitor
References	Casis O, Sanchez-Chapula JA: Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel. J Cardiovasc Pharmacol. 1998 Oct;32(4):521-6. - Pubmed
DTHybrid score	0.3937
Transporter
Name	Transporter
Gene Name	snf
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.9736

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Koyama E, Chiba K, Tani M, Ishizaki T: Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. - Pubmed
DTHybrid score	1.1493
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Shin JG, Park JY, Kim MJ, Shon JH, Yoon YR, Cha IJ, Lee SS, Oh SW, Kim SW, Flockhart DA: Inhibitory effects of tricyclic antidepressants (TCAs) on human cytochrome P450 enzymes in vitro: mechanism of drug interaction between TCAs and phenytoin. Drug Metab Dispos. 2002 Oct;30(10):1102-7. - Pubmed Morinobu S, Tanaka T, Kawakatsu S, Totsuka S, Koyama E, Chiba K, Ishizaki T, Kubota T: Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy. Psychiatry Clin Neurosci. 1997 Aug;51(4):253-7. - Pubmed Madsen H, Rasmussen BB, Brosen K: Imipramine demethylation in vivo: impact of CYP1A2, CYP2C19, and CYP3A4. Clin Pharmacol Ther. 1997 Mar;61(3):319-24. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Koyama E, Chiba K, Tani M, Ishizaki T: Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. - Pubmed Obach RS, Reed-Hagen AE: Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach. Drug Metab Dispos. 2002 Jul;30(7):831-7. - Pubmed
DTHybrid score	0.7302
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Brosen K: Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet. 1995;29 Suppl 1:20-5. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Koyama E, Chiba K, Tani M, Ishizaki T: Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. - Pubmed
DTHybrid score	0.7914
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Koyama E, Chiba K, Tani M, Ishizaki T: Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. - Pubmed
DTHybrid score	1.2651
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4199
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5415
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2856
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5556

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score	0.818
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
DTHybrid score	0.5315
Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
DTHybrid score	0.4489
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Wu X, Huang W, Ganapathy ME, Wang H, Kekuda R, Conway SJ, Leibach FH, Ganapathy V: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. - Pubmed
DTHybrid score	0.3053
Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Actions	inhibitor
References	Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):315-27. - Pubmed
DTHybrid score	0.2997

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.818
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions
References	Not Available
DTHybrid score	0.5315
Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions
References	Not Available
DTHybrid score	0.4489
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions
References	Not Available
DTHybrid score	0.3053
Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Actions
References	Not Available
DTHybrid score	0.2997

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.6206
4118	Cytochrome P450 3A5	CYP3A5	0.4789
4924	Cytochrome P450 2C8	CYP2C8	0.42
632	Alpha-1B adrenergic receptor	ADRA1B	0.3511
831	D(2) dopamine receptor	DRD2	0.3225
318	Alpha-2A adrenergic receptor	ADRA2A	0.3164
713	Sodium-dependent dopamine transporter	SLC6A3	0.2989
590	5-hydroxytryptamine 2C receptor	HTR2C	0.2691
118	Organic cation/carnitine transporter 2	SLC22A5	0.2429
6024	Cytochrome P450 1A1	CYP1A1	0.2407
587	Serum albumin	ALB	0.2389
23	D(1A) dopamine receptor	DRD1	0.2348
320	5-hydroxytryptamine 1A receptor	HTR1A	0.2299
5718	Cytochrome P450 2A6	CYP2A6	0.2102
629	Alpha-2B adrenergic receptor	ADRA2B	0.1809
378	Alpha-2C adrenergic receptor	ADRA2C	0.1752
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1673
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.1647
3923	Cholinesterase	BCHE	0.1565
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.154
766	Beta-2 adrenergic receptor	ADRB2	0.1426
193	Beta-1 adrenergic receptor	ADRB1	0.1344
432	D(4) dopamine receptor	DRD4	0.1323
638	D(3) dopamine receptor	DRD3	0.1319
3941	Amine oxidase [flavin-containing] A	MAOA	0.1282
436	5-hydroxytryptamine 2B receptor	HTR2B	0.1245
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1225
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.1208
862	Multidrug resistance-associated protein 1	ABCC1	0.1093
20	Prostaglandin G/H synthase 1	PTGS1	0.1083
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.107
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.106
1729	Solute carrier family 22 member 6	SLC22A6	0.1026
131	Synaptic vesicular amine transporter	SLC18A2	0.1015
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1001
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0969
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0952
6142	Solute carrier family 22 member 8	SLC22A8	0.0923
3939	Amine oxidase [flavin-containing] B	MAOB	0.0917
725	5-hydroxytryptamine 1D receptor	HTR1D	0.091
716	5-hydroxytryptamine 7 receptor	HTR7	0.0854
163	D(1B) dopamine receptor	DRD5	0.0832
465	Calmodulin	CALM1	0.082
1898	Cytochrome P450 1B1	CYP1B1	0.0784
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0775
124	Histamine H2 receptor	HRH2	0.0752
696	Kappa-type opioid receptor	OPRK1	0.073
776	Bile salt export pump	ABCB11	0.0725
467	Delta-type opioid receptor	OPRD1	0.0722
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0714
3811	Cytochrome P450 19A1	CYP19A1	0.0682
847	Mu-type opioid receptor	OPRM1	0.0669
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0666
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0563
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0555
474	Acetylcholinesterase	ACHE	0.0544
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.053
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0515
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0514
6143	Solute carrier family 22 member 7	SLC22A7	0.0512
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0505
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0505
1656	CYP2B protein	CYP2B	0.0495
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0488
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0486
2164	Multidrug resistance-associated protein 4	ABCC4	0.0484
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0478
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.047
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0467
1618	High affinity nerve growth factor receptor	NTRK1	0.0464
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0462
290	Prostaglandin G/H synthase 2	PTGS2	0.046
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0456
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0451
817	DNA topoisomerase 2-alpha	TOP2A	0.0448
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0447
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0446
731	HIV-1 protease	HIV-1 protease	0.0445
1517	Beta-3 adrenergic receptor	ADRB3	0.0444
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0437
468	Cytochrome P450 4A11	CYP4A11	0.0431
136	Estrogen receptor	ESR1	0.0421
260	Cytochrome P450 51	ERG11	0.0418
761	Cytochrome P450 51	ERG11	0.0418
3163	Cytochrome P450 51	cyp51	0.0418
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0412
6031	Cytochrome P450 3A43	CYP3A43	0.041
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0405
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0401
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0394
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0391
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.039
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0381
6182	Cytochrome P450 2J2	CYP2J2	0.0375
477	DNA topoisomerase 4 subunit A	parC	0.0374
886	DNA topoisomerase 4 subunit A	parC	0.0374
6226	DNA topoisomerase 4 subunit A	parC	0.0374
404	DNA gyrase subunit A	gyrA	0.0369
6224	DNA gyrase subunit A	gyrA	0.0369
94	5-hydroxytryptamine 4 receptor	HTR4	0.0365
871	Glucocorticoid receptor	NR3C1	0.0364
6148	Multidrug resistance-associated protein 7	ABCC10	0.0364
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0362
1024	Solute carrier family 22 member 11	SLC22A11	0.0355
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0346
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0339
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0335
1757	Myeloperoxidase	MPO	0.0334
2129	Sucrase-isomaltase, intestinal	SI	0.0331
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0331
380	Cytochrome P450 17A1	CYP17A1	0.0322
904	Glutathione S-transferase P	GSTP1	0.0318
828	Phenylalanine-4-hydroxylase	PAH	0.0315
3109	Phenylalanine-4-hydroxylase	phhA	0.0315
1636	Trace amine-associated receptor 1	TAAR1	0.0314
1341	Histamine H3 receptor	HRH3	0.0306
174	Sigma 1-type opioid receptor	SIGMAR1	0.0303
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.03
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0298
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0297
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0295
6138	Multidrug resistance protein 3	ABCB4	0.0292
3947	Xanthine dehydrogenase/oxidase	XDH	0.0291
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.029
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0288
844	Epidermal growth factor receptor	EGFR	0.0285
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0283
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0283
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0283
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0283
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0282
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.028
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0277
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0274
161	Tubulin beta chain	TUBB	0.0265
312	Tubulin beta chain	TUB2	0.0265
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0264
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0263
36	Insulin receptor	INSR	0.0258
6141	Sodium/bile acid cotransporter	SLC10A1	0.0258
756	Sex hormone-binding globulin	SHBG	0.0257
6136	Multidrug resistance-associated protein 5	ABCC5	0.0257
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0256
6014	Cytochrome P450 2A13	CYP2A13	0.0249
164	Histamine H4 receptor	HRH4	0.0247
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0242
2472	Voltage-gated potassium channel	kcsA	0.0239
6366	Voltage-gated potassium channel	kcsA	0.0239
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0237
723	Cytosolic phospholipase A2	PLA2G4A	0.0236
4604	Liver carboxylesterase 1	CES1	0.0235
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0235
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0235
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0235
449	Ornithine decarboxylase	ODC1	0.0233
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0233
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0228
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0227
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0226
614	Progesterone receptor	PGR	0.0226
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0226
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0226
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0226
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0226
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0223
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0223
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0222
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.022
4120	NADPH--cytochrome P450 reductase	POR	0.022
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0218
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0214
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0212
3560	Gentamicin 3'-acetyltransferase	aacC1	0.021
122	P2Y purinoceptor 12	P2RY12	0.021
2429	Putrescine-binding periplasmic protein	potF	0.0206
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0203
504	Mast/stem cell growth factor receptor	KIT	0.0202
7	Nitric oxide synthase, inducible	NOS2	0.0201
6137	Multidrug resistance-associated protein 6	ABCC6	0.02
146	Androgen receptor	AR	0.0198
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0197
4773	Deoxycytidine kinase	DCK	0.0197
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0197
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0197
6070	Nischarin	NISCH	0.0196
482	Glycine receptor subunit alpha-1	GLRA1	0.0194
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0193
869	Estrogen receptor beta	ESR2	0.0192
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0192
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0189
5126	Arginase	rocF	0.0187
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0187
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0186
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0186
4203	Histamine N-methyltransferase	HNMT	0.0185
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0185
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0182
818	50S ribosomal protein L10	rplJ	0.0181
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0181
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0181
738	Monocarboxylate transporter 1	SLC16A1	0.0179
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0179
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0174
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0174
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0173
6220	Aryl hydrocarbon receptor	AHR	0.0173
16	Adenosine A1 receptor	ADORA1	0.0172
811	Translocator protein	TSPO	0.0172
777	Tumor necrosis factor	TNF	0.017
737	Mineralocorticoid receptor	NR3C2	0.0169
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0169
516	Neurotensin receptor type 2	NTSR2	0.0168
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0166
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0165
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0163
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0162
5626	Nucleoside diphosphate kinase B	NME2	0.0162
1010	Cytochrome P450 51A1	CYP51A1	0.0161
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.016
6151	Monocarboxylate transporter 10	SLC16A10	0.016
6010	Thiamine transporter 1	SLC19A2	0.0159
3426	Glutamine synthetase	glnA	0.0159
3987	Glutamine synthetase	GLUL	0.0159
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0159
29	Tubulin beta-1 chain	TUBB1	0.0158
85	Growth hormone receptor	GHR	0.0156
1178	Adenosine A2a receptor	ADORA2A	0.0155
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0154
921	Glutamate receptor 2	GRIA2	0.0154
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0153
6102	Arylamine N-acetyltransferase 2	NAT2	0.0153
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.015
976	Platelet glycoprotein IX	GP9	0.015
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0149
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0149
624	Guanidinoacetate N-methyltransferase	GAMT	0.0147
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0146
150	Cationic amino acid transporter 3	SLC7A3	0.0144
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.0144
58	Cationic amino acid transporter 4	SLC7A4	0.0144
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0143
175	Thiamin pyrophosphokinase 1	TPK1	0.0142
303	Diamine acetyltransferase 2	SAT2	0.0141
1317	Spermine synthase	SMS	0.0141
623	Spermine oxidase	SMOX	0.0141
2300	Lysozyme	E	0.0141
3633	Lysozyme	R	0.0141
5597	Lysozyme	17	0.0141
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.014
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0138
26	Vascular endothelial growth factor receptor 3	FLT4	0.0136
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0136
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0136
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0136
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0136
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0136
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0135
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0135
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0134
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0134
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0134
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0134
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0132
705	Glutamate receptor 1	GRIA1	0.0132
32	Vascular endothelial growth factor receptor 1	FLT1	0.013
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0129
5294	Nucleoside diphosphate kinase A	NME1	0.0129
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0128
6146	High affinity copper uptake protein 1	SLC31A1	0.0127
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0127
123	Diamine acetyltransferase 1	SAT1	0.0127
1050	Bile salt sulfotransferase	SULT2A1	0.0126
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
373	Transthyretin	TTR	0.0123
407	Vascular endothelial growth factor receptor 2	KDR	0.0123
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0121
751	Potassium channel subfamily K member 6	KCNK6	0.012
232	Corticosteroid-binding globulin	SERPINA6	0.012
908	Glutathione S-transferase theta-1	GSTT1	0.0118
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0118
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0117
768	FK506-binding protein 1A	FKBP1A	0.0117
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0117
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
319	Opioid receptor, sigma 1	OPRS1	0.0117
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0116
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0116
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0116
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0116
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0116
183	Vascular endothelial growth factor A	VEGFA	0.0116
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0115
1192	Sulfotransferase 1A1	SULT1A1	0.0115
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0115
2539	Tubulin alpha-1 chain	TUBA4A	0.0114
153	Dopamine beta-hydroxylase	DBH	0.0114
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
1353	DNA topoisomerase 1	TOP1	0.0113
3552	DNA topoisomerase 1	topA	0.0113
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0112
1275	Estrogen sulfotransferase	SULT1E1	0.0112
221	Lysyl-tRNA synthetase	KARS	0.0112
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0111
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0111
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0111
952	Dipeptidyl peptidase 4	DPP4	0.011
172	Potassium channel subfamily K member 1	KCNK1	0.011
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0109
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0108
6020	Aldehyde oxidase	AOX1	0.0108
4122	Histone deacetylase 2	HDAC2	0.0108
427	Substance-P receptor	TACR1	0.0108
6165	Copper-transporting ATPase 1	ATP7A	0.0107
6163	Copper-transporting ATPase 2	ATP7B	0.0107
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0105
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0105
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0105
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0105
769	High-affinity choline transporter 1	SLC5A7	0.0105
3927	Choline transporter-like protein 3	SLC44A3	0.0105
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0105
3926	Choline transporter-like protein 2	SLC44A2	0.0105
1686	Choline transporter-like protein 1	SLC44A1	0.0105
861	Choline kinase alpha	CHKA	0.0105
700	Choline dehydrogenase, mitochondrial	CHDH	0.0105
3925	Choline transporter-like protein 4	SLC44A4	0.0105
576	Choline O-acetyltransferase	CHAT	0.0105
3922	Phospholipase D2	PLD2	0.0105
3924	Phospholipase D1	PLD1	0.0105
5682	Ribonuclease pancreatic	RNASE1	0.0104
891	Dihydropteroate synthase	folP	0.0104
5359	Dihydropteroate synthase	folP	0.0104
7175	Dihydropteroate synthase	sulI	0.0104
3810	Catechol O-methyltransferase	COMT	0.0104
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0104
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0104
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0102
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
1830	5'-nucleotidase	NT5E	0.01
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0099
619	Low-affinity cationic amino acid transporter 2	SLC7A2	0.0098
694	Matrix protein 2	M	0.0098
2449	Tubulin alpha-3 chain	TUBA1A	0.0098
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
3808	Dihydropteroate synthase 2	folP2	0.0097
3601	Dihydropteroate synthase 1	folP1	0.0097
3807	Dihydropteroate synthase 1	folP1	0.0097
571	Melatonin receptor type 1A	MTNR1A	0.0096
362	Melatonin receptor type 1B	MTNR1B	0.0096
70	Type-1 angiotensin II receptor	AGTR1	0.0095
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0094
896	Glutathione S-transferase Mu 1	GSTM1	0.0094
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0093
6174	50S ribosomal protein L32	rpmF	0.0093
6085	Fatty acid-binding protein, intestinal	FABP2	0.0092
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
4237	50S ribosomal protein L22	rplV	0.0091
1864	RET proto-oncogene	RET	0.0091
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.009
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.009
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.009
84	Nuclear receptor 0B1	NR0B1	0.009
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0089
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0089
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0087
702	UMP-CMP kinase	CMPK1	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0085
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0085
295	Carbonic anhydrase 1	CA1	0.0084
5787	Angiopoietin-1 receptor	TEK	0.0083
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0081
592	Carbonic anhydrase 4	CA4	0.0081
125	DNA polymerase beta	POLB	0.0081
1629	Transcription factor AP-1	JUN	0.0081
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
3611	Cytidine deaminase	cdd	0.008
3707	Cytidine deaminase	cdd	0.008
4211	Cytidine deaminase	CDA	0.008
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0079
6171	Solute carrier family 28 member 3	SLC28A3	0.0079
273	Apoptosis regulator Bcl-2	BCL2	0.0079
4238	50S ribosomal protein L4	rplD	0.0079
5578	50S ribosomal protein L4	rplD	0.0079
6173	50S ribosomal protein L4	rplD	0.0079
6219	50S ribosomal protein L4	rplD	0.0079
173	Toll-like receptor 7	TLR7	0.0079
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0079
1770	Phospholipase C	PLCL1	0.0079
2841	Phospholipase C	plc	0.0079
365	Dihydrofolate reductase	DHFR	0.0078
2381	Dihydrofolate reductase	DFR1	0.0078
2833	Dihydrofolate reductase	Not Available	0.0078
2931	Dihydrofolate reductase	folA	0.0078
3544	Dihydrofolate reductase	folA	0.0078
3682	Dihydrofolate reductase	folA	0.0078
6642	Dihydrofolate reductase	folA	0.0078
6756	Dihydrofolate reductase	dfrA	0.0078
814	Ryanodine receptor 1	RYR1	0.0077
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0077
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0077
563	Thyroid peroxidase	TPO	0.0076
244	Angiotensin-converting enzyme	ACE	0.0076
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0076
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0076
233	Potassium channel subfamily K member 2	KCNK2	0.0076
923	Glutamate receptor 3	GRIA3	0.0075
284	DNA-directed RNA polymerase beta chain	rpoB	0.0075
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0075
3932	Glutathione S-transferase A2	GSTA2	0.0075
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0074
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0073
3937	Fatty-acid amide hydrolase	FAAH	0.0073
444	Alcohol dehydrogenase 1B	ADH1B	0.0073
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
780	Retinoic acid receptor RXR-gamma	RXRG	0.0071
1074	Urokinase-type plasminogen activator	PLAU	0.0071
251	Alcohol dehydrogenase 1A	ADH1A	0.0071
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.007
511	5-hydroxytryptamine 1F receptor	HTR1F	0.007
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0069
518	Peroxidase/catalase T	katG	0.0069
165	FL cytokine receptor	FLT3	0.0069
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0069
275	Arachidonate 5-lipoxygenase	ALOX5	0.0069
291	Nitric-oxide synthase, endothelial	NOS3	0.0067
823	Fibroblast growth factor receptor 2	FGFR2	0.0067
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0067
6766	O-GlcNAcase BT_4395	BT_4395	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0065
88	Retinoic acid receptor RXR-beta	RXRB	0.0064
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0064
6168	Solute carrier family 22 member 16	SLC22A16	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1852	Microtubule-associated protein 2	MAP2	0.0063
6167	Organic solute transporter subunit beta	OSTB	0.0063
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0063
6166	Organic solute transporter subunit alpha	OSTA	0.0063
469	Annexin A1	ANXA1	0.0063
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0063
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0062
2112	Toll-like receptor 9	TLR9	0.0062
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0061
357	Carbonic anhydrase 2	CA2	0.0061
719	Retinoic acid receptor responder protein 1	RARRES1	0.0061
770	Retinoic acid-induced protein 3	GPRC5A	0.0061
6097	Protein S100-A2	S100A2	0.006
1810	Protein S100-A1	S100A1	0.006
1483	Membrane copper amine oxidase	AOC3	0.006
6859	Protein S100-A4	S100A4	0.006
6044	Serum paraoxonase/lactonase 3	PON3	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0059
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0059
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
6126	Carbonic anhydrase 7	CA7	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
68	Cannabinoid receptor 1	CNR1	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
856	Vitamin D3 receptor	VDR	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
499	Arginine decarboxylase	ADC	0.0057
517	Alcohol dehydrogenase 1C	ADH1C	0.0056
1374	Natriuretic peptides B	NPPB	0.0056
1827	Gap junction alpha-1 protein	GJA1	0.0056
1908	Vascular cell adhesion protein 1	VCAM1	0.0056
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0055
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0055
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0055
4311	tRNA	TRDMT1	0.0055
4325	tRNA	trmD	0.0055
4328	tRNA	trmD	0.0055
6506	Stathmin-4	STMN4	0.0055
577	Argininosuccinate lyase	ASL	0.0054
65	Matrix metalloproteinase-9	Not Available	0.0054
239	Coagulation factor X	F10	0.0054
162	Retinoic acid receptor gamma-1	RARG	0.0054
834	Arginase-2, mitochondrial	ARG2	0.0054
4192	DNA topoisomerase 2-beta	TOP2B	0.0054
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
569	Retinal dehydrogenase 2	ALDH1A2	0.0053
6149	Solute carrier family 22 member 10	SLC22A10	0.0052
2230	Catalase	CAT	0.0052
3249	Catalase	katA	0.0052
3625	Catalase	katA	0.0052
4539	Catalase	katA	0.0052
4941	Catalase	katB	0.0052
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0052
1630	Integrin beta-2	ITGB2	0.0052
49	Endothelin B receptor	EDNRB	0.0052
712	Tubulin alpha chain	TUB1	0.0052
6211	Tubulin epsilon chain	TUBE1	0.0052
6212	Tubulin gamma-1 chain	TUBG1	0.0052
6210	Tubulin delta chain	TUBD1	0.0052
3090	Chitosanase	csn	0.0052
1048	Protein S100-A13	S100A13	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
2226	Protein S100-A12	S100A12	0.0052
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0052
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0051
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0051
740	Argininosuccinate synthase	ASS1	0.0051
865	Argininosuccinate synthase	ASS1	0.0051
2680	Argininosuccinate synthase	argG	0.0051
3194	Argininosuccinate synthase	argG	0.0051
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
4103	Proteasome subunit beta type 2	PSMB2	0.005
4102	Proteasome subunit beta type 5	PSMB5	0.005
4101	Proteasome subunit beta type 1	PSMB1	0.005
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.005
611	Retinal dehydrogenase 1	ALDH1A1	0.0049
578	Endothelin-1 receptor	EDNRA	0.0049
6043	Putative G-protein coupled receptor 44	GPR44	0.0049
3404	Exotoxin A	eta	0.0049
2132	Protein S100-B	S100B	0.0049
1039	Histone deacetylase 9	HDAC9	0.0048
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0047
5300	Antigen peptide transporter 1	TAP1	0.0047
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
581	Cytochrome P450 2R1	CYP2R1	0.0046
1253	Interferon gamma	IFNG	0.0046
551	Carnitine O-acetyltransferase	CRAT	0.0046
3809	Estrogen-related receptor gamma	ESRRG	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0046
3957	Adenosine deaminase	ADA	0.0045
634	Squalene monooxygenase	SQLE	0.0045
7196	Squalene monooxygenase	ERG1	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
3913	Glutamic acid decarboxylase	GAD65	0.0044
4116	Dihydropteroate synthetase	Not Available	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
117	Sterol O-acyltransferase 1	SOAT1	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
6218	Pannexin-1	PANX1	0.0043
4217	Telomerase reverse transcriptase	TERT	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0042
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0042
5923	Microtubule-associated protein tau	MAPT	0.0041
5924	Microtubule-associated protein 4	MAP4	0.0041
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0041
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0041
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0041
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0041
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0041
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0041
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0041
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0041
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0041
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0041
33	Cystine/glutamate transporter	SLC7A11	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
5934	Cytochrome P450 26A1	CYP26A1	0.004
1262	Corticotropin-lipotropin	POMC	0.004
3856	Fibroblast growth factor receptor 3	FGFR3	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
1196	Complement decay-accelerating factor	CD55	0.0039
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
820	Glycine receptor subunit alpha-2	GLRA2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0037
992	Protein tyrosine kinase 2 beta	PTK2B	0.0037
3904	Alanine aminotransferase 2	GPT2	0.0037
735	Alanine aminotransferase 1	GPT	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
527	Prostacyclin receptor	PTGIR	0.0036
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0036
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
1992	Vitamin D-binding protein	GC	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
2808	Chloramphenicol acetyltransferase 3	cat3	0.0034
936	Ephrin type-A receptor 2	EPHA2	0.0034
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0034
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0034
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
2320	Thymidine kinase, cytosolic	TK1	0.0033
1525	Heparin-binding growth factor 2	FGF2	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
2298	Cytochrome P450-cam	camC	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
24	Thymidylate synthase	TMP1	0.0032
359	Thymidylate synthase	TYMS	0.0032
2626	Thymidylate synthase	thyA	0.0032
2729	Thymidylate synthase	thyA	0.0032
5352	Thymidylate synthase	THYA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0031
2417	Chloramphenicol acetyltransferase	cat	0.0031
3278	Chloramphenicol acetyltransferase	cat	0.0031
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0031
489	Monocarboxylate transporter 2	SLC16A7	0.0031
6824	Tyrosine-protein kinase Lyn	LYN	0.0031
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0031
2810	Dr hemagglutinin structural subunit	draA	0.003
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
106	Cannabinoid receptor 2	CNR2	0.003
358	Cystathionine beta-synthase	CBS	0.003
3868	Calcineurin subunit B isoform 2	PPP3R2	0.003
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.003
572	Integrin alpha-L	ITGAL	0.0029
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
267	Plasminogen activator inhibitor 1	SERPINE1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0027
54	Prothrombin	F2	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0026
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
6048	Troponin C, skeletal muscle	TNNC2	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
6221	Steroid hormone receptor ERR1	ESRRA	0.0026
268	Adenosine A2b receptor	ADORA2B	0.0026
1648	Elastin	ELN	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0025
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0025
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0025
1268	Neuropeptide S receptor	NPSR1	0.0025
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0025
459	Retinoic acid receptor RXR-alpha	RXRA	0.0025
5798	Mitogen-activated protein kinase 11	MAPK11	0.0025
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
3086	Plasmepsin-2	Not Available	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
6073	Potassium channel subfamily K member 9	KCNK9	0.0023
6072	Potassium channel subfamily K member 3	KCNK3	0.0023
6131	Carbonic anhydrase 14	CA14	0.0023
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0023
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0023
2207	Rhodopsin	RHO	0.0022
2599	Tyrosine-protein kinase HCK	HCK	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
298	Renin	REN	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
2091	Endoplasmin	HSP90B1	0.0021
3221	Cytochrome c4	cc4	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
400	Coagulation factor IX	F9	0.0021
5461	Coagulation factor IX	F9	0.0021
293	Gamma-glutamyl hydrolase	GGH	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0019
2236	Casein kinase II subunit alpha	CSNK2A1	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
6459	Glycodelin	PAEP	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0019
604	Vitamin K-dependent protein Z	PROZ	0.0019
3587	Gastrotropin	FABP6	0.0019
558	Solute carrier family 12 member 1	SLC12A1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0018
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0018
1650	Heme carrier protein 1	SLC46A1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
3830	Calreticulin	CALR	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
484	Tyrosine-protein kinase ABL2	ABL2	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
422	Vitamin K-dependent protein C	PROC	0.0017
1245	Vitamin K-dependent protein S	PROS1	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0017
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0017
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
2216	Fibroblast growth factor receptor 4	FGFR4	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
76	Nitric-oxide synthase, brain	NOS1	0.0016
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0016
1243	Cathepsin D	CTSD	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0015
3233	Bile acid receptor	NR1H4	0.0015
2408	Tyrosine-protein kinase SYK	SYK	0.0015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0015
6755	Poliovirus receptor	PVR	0.0015
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1541	Metalloproteinase	mmp20	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
798	Osteocalcin	BGLAP	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
4954	Soluble cytochrome b558	Not Available	0.0014
4925	Cytochrome c-type protein SHP	shp	0.0014
4934	Cytochrome c-551	nirM	0.0014
5218	Cytochrome c-551	nirM	0.0014
4905	Cytochrome c2	Not Available	0.0014
4939	Cytochrome c2	cycA	0.0014
4964	Cytochrome c2	cycA	0.0014
4979	Cytochrome c2	cycA	0.0014
6673	Cytochrome c2	cycA	0.0014
4915	Cytochrome c-550	psbV	0.0014
4959	Cytochrome c-550	psbV	0.0014
5216	Cytochrome c-550	psbV	0.0014
4947	Bacterial hemoglobin	vhb	0.0014
4984	Neuroglobin	NGB	0.0014
4998	Hemoglobin-like protein yjbI	yjbI	0.0014
4975	Cytochrome c-556	RPA3973	0.0014
4943	Cytochrome c6	petJ	0.0014
4916	Cyanoglobin	glbN	0.0014
4994	Hemoglobin-like protein HbO	glbO	0.0014
4907	Cytochrome c-L	moxG	0.0014
6865	Cytochrome c-L	moxG	0.0014
4936	Cytochrome c2 iso-2	Not Available	0.0014
4909	CooA protein	cooA	0.0014
644	Heme oxygenase 2	HMOX2	0.0014
4982	Heme oxygenase 2	pbsA2	0.0014
4942	Diheme cytochrome c napB	napB	0.0014
4910	Cytoglobin	CYGB	0.0014
4981	Iron-starvation protein PigA	pigA	0.0014
4935	Cytochrome c-554	cycA1	0.0014
4971	Nonaheme cytochrome c	hmcA	0.0014
4961	Hemophore HasA	hasA	0.0014
4904	Cytochrome c family protein	GSU1996	0.0014
4976	Apocytochrome f	petA	0.0014
6407	Apocytochrome f	petA	0.0014
5000	HemO	hemO	0.0014
4989	Cytochrome c551 peroxidase	ccp	0.0014
5222	Cytochrome c551 peroxidase	ccpA	0.0014
4960	Putative cytochrome P450-family protein	SCO7417	0.0014
4931	Cytochrome P450 167A1	CYP167A1	0.0014
4764	Cytochrome P450 165C4	CYP165C4	0.0014
4999	Cytochrome P450 165B3	CYP165B3	0.0014
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0014
4972	P450cin	cinA	0.0014
4903	Methyl-accepting chemotaxis protein	Tar4	0.0014
4993	Hydroxylamine oxidoreductase	hao1	0.0014
4937	Cytochrome oxidase subunit II	rcoxA	0.0014
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0014
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0014
3093	Catalase HPII	katE	0.0014
4922	Cytochrome c, putative	SO_4144	0.0014
4952	Catalase/peroxidase	katA	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
369	Coagulation factor VII	F7	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
2021	Thrombomodulin	THBD	0.0012
1295	Fatty acid synthase	FASN	0.0012
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2802	Endoglucanase G	celCCG	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4920	Peroxidase/catalase	katG	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
2119	Cytochrome b5	CYB5A	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.001
4990	PpcA	ppcA	0.001
3375	Acidic cytochrome c3	Not Available	0.001
4988	Sulfite oxidase, mitochondrial	SUOX	0.001
4385	Cytochrome c'	Not Available	0.001
4967	Cytochrome c'	cycA	0.001
5038	Cytochrome c'	Not Available	0.001
5223	Cytochrome c'	cycP	0.001
2915	Sensor protein fixL	fixL	0.001
4944	Sensor protein fixL	fixL	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
3570	Cytochrome P450 152A1	cypC	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
4992	Cytochrome c peroxidase	Not Available	0.001
4813	Heme oxygenase	hmuO	0.001
5769	Heme oxygenase	Not Available	0.001
4289	Cytochrome P450	TT_P0059	0.001
6262	Cytochrome P450	staP	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
997	Protein kinase C beta type	PRKCB	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
6042	Prostaglandin reductase 2	PTGR2	0.0009
3670	Soluble cytochrome b562 precursor	cybC	0.0009
3411	Cytochrome P450 121	cyp121	0.0009
3291	Cytochrome c-552	cycA	0.0009
4927	Cytochrome c-552	nrfA	0.0009
4938	Cytochrome c-552	cycA	0.0009
4953	Cytochrome c-552	nrfA	0.0009
5217	Cytochrome c-552	cycM	0.0009
2617	Nitric oxide synthase oxygenase	nos	0.0009
2701	Nitric oxide synthase oxygenase	nos	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
3102	Flavohemoprotein	hmp	0.0008
4969	Flavohemoprotein	hmp	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
1792	Tissue-type plasminogen activator	PLAT	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
1867	Major prion protein	PRNP	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
3127	Nitrite reductase	nirS	0.0008
3284	Nitrite reductase	nirS	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0008
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
4608	Putative cytochrome P450	SCO1207	0.0007
4963	Putative cytochrome P450	SCO2884	0.0007
6254	Putative cytochrome P450	SCO6998	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
822	Aldose reductase	AKR1B1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1313	Lactoylglutathione lyase	GLO1	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
1507	Cytochrome c	CYCS	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
693	Hemoglobin subunit beta	HBB	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
6677	Myelin P2 protein	PMP2	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6268	Hydroxyacid oxidase 1	HAO1	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
810	Heme oxygenase 1	HMOX1	0.0006
3391	Heme oxygenase 1	pbsA1	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00458 - Imipramine

Targets

Enzymes

Transporters

Carriers

Predictions