DT-Web: DB00476

Identification

Name

Duloxetine

Accession Number

DB00476 (APRD00060)

Type

small molecule

Description

Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company. Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia. Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

297.415

Groups

approved

Monoisotopic Weight

297.118734925

Pharmacology

Indication

For the acute and maintenance treatment of major depressive disorder (MDD), as well as acute management of generalized anxiety disorder. Also used for the management of neuropathic pain associated with diabetic peripheral neuropathy, and fibromyalgia. Has been used in the management of moderate to severe stress urinary incontinence (SUI) in women.

Mechanism of action

Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors. The antidepressant and pain inhibitory actions of duloxetine are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS. The mechanism of action of duloxetine in SUI has not been determined, but is thought to be associated with the potentiation of serotonin and norepinephrine activity in the spinal cord, which increases urethral closure forces and thereby reduces involuntary urine loss.

Absorption

Orally administered duloxetine hydrochloride is well absorbed.

Protein binding

Protein binding is greater than 90%.

Biotransformation

The major biotransformation pathways for duloxetine involve oxidation of the naphthyl ring followed by conjugation and further oxidation. Both CYP2D6 and CYP1A2 catalyze the oxidation of the naphthyl ring in vitro. Metabolites found in plasma include 4-hydroxy duloxetine glucuronide and 5-hydroxy, 6-methoxy duloxetine sulfate. The major circulating metabolites have not been shown to contribute significantly to the pharmacologic activity of duloxetine.

Route of elimination

Many additional metabolites have been identified in urine, some representing only minor pathways of elimination. Most (about 70%) of the duloxetine dose appears in the urine as metabolites of duloxetine; about 20% is excreted in the feces.

Toxicity

Oral, rat LD₅₀: 491 mg/kg for males and 279 mg/kg for females. Symptoms of overdose include tremors, convulsions, reduced activity, slow pupillary response, intermittent tremors, and rigidity.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amitriptyline	Possible increase in the levels of this agent when used with duloxetine
Ciprofloxacin	Ciprofloxacin, a strong CYP1A2 inhibitor, may decrease the metabolism of duloxetine. Monitor for changes in the therapeutic and adverse effects of duloxetine if ciprofloxacin is initiated or discontinued.
Desipramine	Possible increase in the levels of this agent when used with duloxetine
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Flecainide	Possible increase in the levels of this agent when used with duloxetine
Fluvoxamine	Fluvoxamine increases the effect and toxicity of duloxetine
Imipramine	Possible increase in the levels of this agent when used with duloxetine
Isocarboxazid	Possible severe adverse reaction with this combination
Nortriptyline	Possible increase in the levels of this agent when used with duloxetine
Phenelzine	Possible severe adverse reaction with this combination
Propafenone	Possible increase in the levels of this agent when used with duloxetine
Rasagiline	Possible severe adverse reaction with this combination
Tamoxifen	Duloxetine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Duloxetine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Duloxetine is initiated, discontinued, or dose changed.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Duloxetine. Consider alternate therapy or monitor for therapeutic/adverse effects of Duloxetine if Terbinafine is initiated, discontinued or dose changed.
Thiabendazole	The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Duloxetine by decreasing Duloxetine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Duloxetine if Thiabendazole is initiated, discontinued or dose changed.
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Tramadol	Duloxetine may decrease the effect of Tramadol by decreasing active metabolite production. Increased risk of serotonin syndrome. Monitor for Tramadol efficacy and symptoms of serotonin syndrome.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Triprolidine	The CNS depressants, Triprolidine and Duloxetine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and duloxetine, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.

Food Interactions

Food does not affect maximum levels reached, but delays it (from 6 to 10 hours) and total product exposure appears to be reduced by only 10%.
People taking this product who drink large amounts of alcohol are exposed to a higher risk of liver toxicity.
Take without regard to meals.

Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Chen F, Larsen MB, Sanchez C, Wiborg O: The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors. Eur Neuropsychopharmacol. 2005 Mar;15(2):193-8. - Pubmed Troelsen KB, Nielsen EO, Mirza NR: Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter. Psychopharmacology (Berl). 2005 Oct;181(4):741-50. Epub 2005 Sep 29. - Pubmed Gould GG, Javors MA, Frazer A: Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain. Biol Psychiatry. 2007 Jan 15;61(2):210-5. Epub 2006 May 2. - Pubmed Mirza NR, Nielsen EO, Troelsen KB: Serotonin transporter density and anxiolytic-like effects of antidepressants in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):858-66. Epub 2007 Jan 30. - Pubmed Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. - Pubmed Beique JC, Lavoie N, de Montigny C, Debonnel G: Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15;349(1):129-32. - Pubmed Karpa KD, Cavanaugh JE, Lakoski JM: Duloxetine pharmacology: profile of a dual monoamine modulator. CNS Drug Rev. 2002 Winter;8(4):361-76. - Pubmed van Groeningen CJ, Peters GJ, Pinedo HM: Lack of effectiveness of combined 5-fluorouracil and leucovorin in patients with 5-fluorouracil-resistant advanced colorectal cancer. Eur J Cancer Clin Oncol. 1989 Jan;25(1):45-9. - Pubmed Jost W, Marsalek P: Duloxetine: mechanism of action at the lower urinary tract and Onuf's nucleus. Clin Auton Res. 2004 Aug;14(4):220-7. - Pubmed Trivedi MH, Desaiah D, Ossanna MJ, Pritchett YL, Brannan SK, Detke MJ: Clinical evidence for serotonin and norepinephrine reuptake inhibition of duloxetine. Int Clin Psychopharmacol. 2008 May;23(3):161-9. - Pubmed Bymaster FP, Lee TC, Knadler MP, Detke MJ, Iyengar S: The dual transporter inhibitor duloxetine: a review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression. Curr Pharm Des. 2005;11(12):1475-93. - Pubmed Khullar V, Cardozo L, Dmochowski R: Mixed incontinence: current evidence and future perspectives. Neurourol Urodyn. 2010 Apr;29(4):618-22. - Pubmed Carter NJ, McCormack PL: Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. - Pubmed Hunziker ME, Suehs BT, Bettinger TL, Crismon ML: Duloxetine hydrochloride: a new dual-acting medication for the treatment of major depressive disorder. Clin Ther. 2005 Aug;27(8):1126-43. - Pubmed
DTHybrid score	0.4458
Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Gould GG, Javors MA, Frazer A: Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain. Biol Psychiatry. 2007 Jan 15;61(2):210-5. Epub 2006 May 2. - Pubmed Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. - Pubmed Beique JC, Lavoie N, de Montigny C, Debonnel G: Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15;349(1):129-32. - Pubmed Vincent S, Bieck PR, Garland EM, Loghin C, Bymaster FP, Black BK, Gonzales C, Potter WZ, Robertson D: Clinical assessment of norepinephrine transporter blockade through biochemical and pharmacological profiles. Circulation. 2004 Jun 29;109(25):3202-7. Epub 2004 Jun 7. - Pubmed Schou M, Halldin C, Pike VW, Mozley PD, Dobson D, Innis RB, Farde L, Hall H: Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2. Eur Neuropsychopharmacol. 2005 Oct;15(5):517-20. Epub 2005 Apr 7. - Pubmed Mirza NR, Nielsen EO, Troelsen KB: Serotonin transporter density and anxiolytic-like effects of antidepressants in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):858-66. Epub 2007 Jan 30. - Pubmed Karpa KD, Cavanaugh JE, Lakoski JM: Duloxetine pharmacology: profile of a dual monoamine modulator. CNS Drug Rev. 2002 Winter;8(4):361-76. - Pubmed van Groeningen CJ, Peters GJ, Pinedo HM: Lack of effectiveness of combined 5-fluorouracil and leucovorin in patients with 5-fluorouracil-resistant advanced colorectal cancer. Eur J Cancer Clin Oncol. 1989 Jan;25(1):45-9. - Pubmed Jost W, Marsalek P: Duloxetine: mechanism of action at the lower urinary tract and Onuf's nucleus. Clin Auton Res. 2004 Aug;14(4):220-7. - Pubmed Trivedi MH, Desaiah D, Ossanna MJ, Pritchett YL, Brannan SK, Detke MJ: Clinical evidence for serotonin and norepinephrine reuptake inhibition of duloxetine. Int Clin Psychopharmacol. 2008 May;23(3):161-9. - Pubmed Bymaster FP, Lee TC, Knadler MP, Detke MJ, Iyengar S: The dual transporter inhibitor duloxetine: a review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression. Curr Pharm Des. 2005;11(12):1475-93. - Pubmed Khullar V, Cardozo L, Dmochowski R: Mixed incontinence: current evidence and future perspectives. Neurourol Urodyn. 2010 Apr;29(4):618-22. - Pubmed Carter NJ, McCormack PL: Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. - Pubmed Hunziker ME, Suehs BT, Bettinger TL, Crismon ML: Duloxetine hydrochloride: a new dual-acting medication for the treatment of major depressive disorder. Clin Ther. 2005 Aug;27(8):1126-43. - Pubmed
DTHybrid score	0.602
Sodium-dependent dopamine transporter
Name	Sodium-dependent dopamine transporter
Gene Name	SLC6A3
Pharmacological action	unknown
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Carter NJ, McCormack PL: Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. - Pubmed Pereira P, Gianesini J, da Silva Barbosa C, Cassol GF, Von Borowski RG, Kahl VF, Cappelari SE, Picada JN: Neurobehavioral and genotoxic parameters of duloxetine in mice using the inhibitory avoidance task and comet assay as experimental models. Pharmacol Res. 2009 Jan;59(1):57-61. Epub 2008 Oct 5. - Pubmed Hunziker ME, Suehs BT, Bettinger TL, Crismon ML: Duloxetine hydrochloride: a new dual-acting medication for the treatment of major depressive disorder. Clin Ther. 2005 Aug;27(8):1126-43. - Pubmed
DTHybrid score	0.549

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	- Knadler MP, Lobo E, Chappell J, Bergstrom R: Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May 1;50(5):281-94. doi: 10.2165/11539240-000000000-00000. - Pubmed Lobo ED, Bergstrom RF, Reddy S, Quinlan T, Chappell J, Hong Q, Ring B, Knadler MP: In vitro and in vivo evaluations of cytochrome P450 1A2 interactions with duloxetine. Clin Pharmacokinet. 2008;47(3):191-202. - Pubmed Duloxetine: new indication. Depression and diabetic neuropathy: too many adverse effects. Prescrire Int. 2006 Oct;15(85):168-72. - Pubmed Carter NJ, McCormack PL: Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. doi: 10.2165/00023210-200923060-00006. - Pubmed
DTHybrid score	0.3038
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Knadler MP, Lobo E, Chappell J, Bergstrom R: Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May 1;50(5):281-94. doi: 10.2165/11539240-000000000-00000. - Pubmed Preskorn SH, Nichols AI, Paul J, Patroneva AL, Helzner EC, Guico-Pabia CJ: Effect of desvenlafaxine on the cytochrome P450 2D6 enzyme system. J Psychiatr Pract. 2008 Nov;14(6):368-78. - Pubmed Duloxetine: new indication. Depression and diabetic neuropathy: too many adverse effects. Prescrire Int. 2006 Oct;15(85):168-72. - Pubmed Carter NJ, McCormack PL: Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. doi: 10.2165/00023210-200923060-00006. - Pubmed
DTHybrid score	0.4402

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.2446
6016	Cytochrome P450 2C19	CYP2C19	0.1478
4757	Cytochrome P450 2C9	CYP2C9	0.1416
1588	Multidrug resistance protein 1	ABCB1	0.1261
556	Alpha-1A adrenergic receptor	ADRA1A	0.1138
6030	Cytochrome P450 2B6	CYP2B6	0.0995
492	Histamine H1 receptor	HRH1	0.0984
3941	Amine oxidase [flavin-containing] A	MAOA	0.0958
131	Synaptic vesicular amine transporter	SLC18A2	0.0913
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0843
4118	Cytochrome P450 3A5	CYP3A5	0.0789
3939	Amine oxidase [flavin-containing] B	MAOB	0.0781
318	Alpha-2A adrenergic receptor	ADRA2A	0.0765
4924	Cytochrome P450 2C8	CYP2C8	0.076
6013	Cytochrome P450 2E1	CYP2E1	0.0759
632	Alpha-1B adrenergic receptor	ADRA1B	0.067
590	5-hydroxytryptamine 2C receptor	HTR2C	0.067
6024	Cytochrome P450 1A1	CYP1A1	0.0626
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0625
6107	Cytochrome P450 3A7	CYP3A7	0.0625
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0535
5718	Cytochrome P450 2A6	CYP2A6	0.0449
831	D(2) dopamine receptor	DRD2	0.0444
193	Beta-1 adrenergic receptor	ADRB1	0.0436
766	Beta-2 adrenergic receptor	ADRB2	0.0427
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0405
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0399
629	Alpha-2B adrenergic receptor	ADRA2B	0.0376
1636	Trace amine-associated receptor 1	TAAR1	0.0344
23	D(1A) dopamine receptor	DRD1	0.0324
6145	Solute carrier family 22 member 1	SLC22A1	0.0321
6144	Solute carrier family 22 member 2	SLC22A2	0.0321
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0312
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0308
118	Organic cation/carnitine transporter 2	SLC22A5	0.0308
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0306
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0297
378	Alpha-2C adrenergic receptor	ADRA2C	0.029
587	Serum albumin	ALB	0.0287
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0282
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0278
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0266
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0263
36	Insulin receptor	INSR	0.0258
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0256
6147	Solute carrier family 22 member 3	SLC22A3	0.0246
6106	Cytochrome P450 2C18	CYP2C18	0.024
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0239
789	Alpha-1D adrenergic receptor	ADRA1D	0.0227
1656	CYP2B protein	CYP2B	0.0224
3923	Cholinesterase	BCHE	0.0221
20	Prostaglandin G/H synthase 1	PTGS1	0.022
847	Mu-type opioid receptor	OPRM1	0.0211
467	Delta-type opioid receptor	OPRD1	0.0202
696	Kappa-type opioid receptor	OPRK1	0.02
1517	Beta-3 adrenergic receptor	ADRB3	0.0177
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0166
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0159
638	D(3) dopamine receptor	DRD3	0.0148
1757	Myeloperoxidase	MPO	0.0143
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0143
1898	Cytochrome P450 1B1	CYP1B1	0.0141
833	Organic cation/carnitine transporter 1	SLC22A4	0.0138
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0138
474	Acetylcholinesterase	ACHE	0.0138
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0138
6432	Transporter	snf	0.0138
6182	Cytochrome P450 2J2	CYP2J2	0.0129
817	DNA topoisomerase 2-alpha	TOP2A	0.0128
477	DNA topoisomerase 4 subunit A	parC	0.0127
886	DNA topoisomerase 4 subunit A	parC	0.0127
6226	DNA topoisomerase 4 subunit A	parC	0.0127
404	DNA gyrase subunit A	gyrA	0.0125
6224	DNA gyrase subunit A	gyrA	0.0125
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0125
862	Multidrug resistance-associated protein 1	ABCC1	0.0121
432	D(4) dopamine receptor	DRD4	0.0119
1729	Solute carrier family 22 member 6	SLC22A6	0.0119
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0115
3811	Cytochrome P450 19A1	CYP19A1	0.0111
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.011
465	Calmodulin	CALM1	0.011
290	Prostaglandin G/H synthase 2	PTGS2	0.0109
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0105
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0104
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0103
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0103
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0099
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0097
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
94	5-hydroxytryptamine 4 receptor	HTR4	0.0096
163	D(1B) dopamine receptor	DRD5	0.0095
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0095
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.009
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.008
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0079
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0078
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0077
4120	NADPH--cytochrome P450 reductase	POR	0.0076
16	Adenosine A1 receptor	ADORA1	0.0075
731	HIV-1 protease	HIV-1 protease	0.0073
1178	Adenosine A2a receptor	ADORA2A	0.0071
124	Histamine H2 receptor	HRH2	0.007
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0068
776	Bile salt export pump	ABCB11	0.0067
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0065
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0065
173	Toll-like receptor 7	TLR7	0.0063
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0063
565	Extracellular calcium-sensing receptor	CASR	0.0062
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0062
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0061
6220	Aryl hydrocarbon receptor	AHR	0.0061
904	Glutathione S-transferase P	GSTP1	0.0061
482	Glycine receptor subunit alpha-1	GLRA1	0.006
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0057
2164	Multidrug resistance-associated protein 4	ABCC4	0.0056
828	Phenylalanine-4-hydroxylase	PAH	0.0055
3109	Phenylalanine-4-hydroxylase	phhA	0.0055
6143	Solute carrier family 22 member 7	SLC22A7	0.0054
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0054
136	Estrogen receptor	ESR1	0.0053
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0053
777	Tumor necrosis factor	TNF	0.0053
571	Melatonin receptor type 1A	MTNR1A	0.0052
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0052
362	Melatonin receptor type 1B	MTNR1B	0.0052
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0051
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.005
3947	Xanthine dehydrogenase/oxidase	XDH	0.005
468	Cytochrome P450 4A11	CYP4A11	0.0049
716	5-hydroxytryptamine 7 receptor	HTR7	0.0048
6142	Solute carrier family 22 member 8	SLC22A8	0.0047
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0047
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0047
380	Cytochrome P450 17A1	CYP17A1	0.0046
174	Sigma 1-type opioid receptor	SIGMAR1	0.0046
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0045
6014	Cytochrome P450 2A13	CYP2A13	0.0045
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0044
2112	Toll-like receptor 9	TLR9	0.0044
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0044
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0044
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0043
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0043
6031	Cytochrome P450 3A43	CYP3A43	0.0043
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0043
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0043
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0043
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0043
714	Glutathione reductase, mitochondrial	GSR	0.0042
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0042
4122	Histone deacetylase 2	HDAC2	0.0042
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0042
6148	Multidrug resistance-associated protein 7	ABCC10	0.0042
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0041
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.004
504	Mast/stem cell growth factor receptor	KIT	0.004
1618	High affinity nerve growth factor receptor	NTRK1	0.0039
871	Glucocorticoid receptor	NR3C1	0.0039
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0038
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0038
319	Opioid receptor, sigma 1	OPRS1	0.0038
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0036
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0036
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0036
4228	Keratin, type II cytoskeletal 7	KRT7	0.0036
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0035
153	Dopamine beta-hydroxylase	DBH	0.0035
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
273	Apoptosis regulator Bcl-2	BCL2	0.0034
712	Tubulin alpha chain	TUB1	0.0034
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0033
6506	Stathmin-4	STMN4	0.0033
6044	Serum paraoxonase/lactonase 3	PON3	0.0033
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0033
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0032
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0032
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0031
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0031
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0031
260	Cytochrome P450 51	ERG11	0.0031
761	Cytochrome P450 51	ERG11	0.0031
3163	Cytochrome P450 51	cyp51	0.0031
26	Vascular endothelial growth factor receptor 3	FLT4	0.0031
3810	Catechol O-methyltransferase	COMT	0.0031
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0031
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0031
844	Epidermal growth factor receptor	EGFR	0.0031
818	50S ribosomal protein L10	rplJ	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
373	Transthyretin	TTR	0.003
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
32	Vascular endothelial growth factor receptor 1	FLT1	0.003
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0029
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0029
365	Dihydrofolate reductase	DHFR	0.0028
2381	Dihydrofolate reductase	DFR1	0.0028
2833	Dihydrofolate reductase	Not Available	0.0028
2931	Dihydrofolate reductase	folA	0.0028
3544	Dihydrofolate reductase	folA	0.0028
3682	Dihydrofolate reductase	folA	0.0028
6642	Dihydrofolate reductase	folA	0.0028
6756	Dihydrofolate reductase	dfrA	0.0028
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0028
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0028
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0028
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0028
1010	Cytochrome P450 51A1	CYP51A1	0.0028
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0028
1629	Transcription factor AP-1	JUN	0.0028
407	Vascular endothelial growth factor receptor 2	KDR	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
3957	Adenosine deaminase	ADA	0.0026
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0026
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0026
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0026
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0026
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0026
122	P2Y purinoceptor 12	P2RY12	0.0026
6102	Arylamine N-acetyltransferase 2	NAT2	0.0025
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0025
4604	Liver carboxylesterase 1	CES1	0.0025
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0025
891	Dihydropteroate synthase	folP	0.0025
5359	Dihydropteroate synthase	folP	0.0025
7175	Dihydropteroate synthase	sulI	0.0025
146	Androgen receptor	AR	0.0025
161	Tubulin beta chain	TUBB	0.0024
312	Tubulin beta chain	TUB2	0.0024
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0024
6070	Nischarin	NISCH	0.0024
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0024
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
869	Estrogen receptor beta	ESR2	0.0023
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0023
6151	Monocarboxylate transporter 10	SLC16A10	0.0023
70	Type-1 angiotensin II receptor	AGTR1	0.0023
4311	tRNA	TRDMT1	0.0022
4325	tRNA	trmD	0.0022
4328	tRNA	trmD	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
518	Peroxidase/catalase T	katG	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0021
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0021
952	Dipeptidyl peptidase 4	DPP4	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.002
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.002
563	Thyroid peroxidase	TPO	0.002
6020	Aldehyde oxidase	AOX1	0.002
1820	Beta-nerve growth factor	NGF	0.002
1050	Bile salt sulfotransferase	SULT2A1	0.0019
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
2449	Tubulin alpha-3 chain	TUBA1A	0.0019
4203	Histamine N-methyltransferase	HNMT	0.0019
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0019
634	Squalene monooxygenase	SQLE	0.0019
7196	Squalene monooxygenase	ERG1	0.0019
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0019
284	DNA-directed RNA polymerase beta chain	rpoB	0.0019
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0019
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0019
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
543	Penicillin-binding protein 1B	mrcB	0.0018
6186	Penicillin-binding protein 1B	ponB	0.0018
6822	Penicillin-binding protein 1b	pbp1b	0.0018
6844	Penicillin-binding protein 1b	pbp1b	0.0018
6146	High affinity copper uptake protein 1	SLC31A1	0.0018
1192	Sulfotransferase 1A1	SULT1A1	0.0018
33	Cystine/glutamate transporter	SLC7A11	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
645	Penicillin-binding protein 1A	mrcA	0.0018
5805	Penicillin-binding protein 1A	ponA	0.0018
6185	Penicillin-binding protein 1A	mrcA	0.0018
6799	Penicillin-binding protein 1A	pbpA	0.0018
159	Penicillin-binding protein 2B	penA	0.0018
6121	Penicillin-binding protein 2B	penA	0.0018
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0018
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0018
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0018
1024	Solute carrier family 22 member 11	SLC22A11	0.0018
6136	Multidrug resistance-associated protein 5	ABCC5	0.0018
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0017
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0017
1648	Elastin	ELN	0.0017
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0017
6137	Multidrug resistance-associated protein 6	ABCC6	0.0017
275	Arachidonate 5-lipoxygenase	ALOX5	0.0017
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0017
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0016
738	Monocarboxylate transporter 1	SLC16A1	0.0016
1830	5'-nucleotidase	NT5E	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0016
1243	Cathepsin D	CTSD	0.0016
427	Substance-P receptor	TACR1	0.0016
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0016
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0016
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0015
921	Glutamate receptor 2	GRIA2	0.0015
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0015
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0015
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0014
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0014
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0014
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0014
3086	Plasmepsin-2	Not Available	0.0014
976	Platelet glycoprotein IX	GP9	0.0014
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0014
823	Fibroblast growth factor receptor 2	FGFR2	0.0014
1374	Natriuretic peptides B	NPPB	0.0014
1827	Gap junction alpha-1 protein	GJA1	0.0014
1908	Vascular cell adhesion protein 1	VCAM1	0.0014
4103	Proteasome subunit beta type 2	PSMB2	0.0014
4102	Proteasome subunit beta type 5	PSMB5	0.0014
4101	Proteasome subunit beta type 1	PSMB1	0.0014
614	Progesterone receptor	PGR	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0014
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0014
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0014
164	Histamine H4 receptor	HRH4	0.0014
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0013
3404	Exotoxin A	eta	0.0013
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0013
814	Ryanodine receptor 1	RYR1	0.0013
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0013
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0013
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0013
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0013
295	Carbonic anhydrase 1	CA1	0.0013
756	Sex hormone-binding globulin	SHBG	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
6141	Sodium/bile acid cotransporter	SLC10A1	0.0012
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0012
165	FL cytokine receptor	FLT3	0.0012
705	Glutamate receptor 1	GRIA1	0.0012
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0012
232	Corticosteroid-binding globulin	SERPINA6	0.0012
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0012
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0012
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0012
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0012
268	Adenosine A2b receptor	ADORA2B	0.0012
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0012
473	L-lactate dehydrogenase A chain	LDHA	0.0011
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0011
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
6043	Putative G-protein coupled receptor 44	GPR44	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
4192	DNA topoisomerase 2-beta	TOP2B	0.0011
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0011
183	Vascular endothelial growth factor A	VEGFA	0.0011
2290	ADP-ribosyl cyclase 2	BST1	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
239	Coagulation factor X	F10	0.001
4237	50S ribosomal protein L22	rplV	0.001
1714	Mitogen-activated protein kinase 3	MAPK3	0.001
1864	RET proto-oncogene	RET	0.001
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.001
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.001
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.001
737	Mineralocorticoid receptor	NR3C2	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
908	Glutathione S-transferase theta-1	GSTT1	0.001
144	Hemoglobin subunit alpha	HBA1	0.001
1275	Estrogen sulfotransferase	SULT1E1	0.001
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.001
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.001
859	Cellular retinoic acid-binding protein 2	CRABP2	0.001
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.001
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.001
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.001
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.001
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.001
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.001
760	Fibroblast growth factor 1	FGF1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0009
780	Retinoic acid receptor RXR-gamma	RXRG	0.0009
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0009
5934	Cytochrome P450 26A1	CYP26A1	0.0009
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
7	Nitric oxide synthase, inducible	NOS2	0.0009
65	Matrix metalloproteinase-9	Not Available	0.0009
751	Potassium channel subfamily K member 6	KCNK6	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0009
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0009
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0008
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0008
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0008
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0008
459	Retinoic acid receptor RXR-alpha	RXRA	0.0008
3937	Fatty-acid amide hydrolase	FAAH	0.0008
1262	Corticotropin-lipotropin	POMC	0.0008
1341	Histamine H3 receptor	HRH3	0.0008
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0008
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0008
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0008
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0008
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0008
88	Retinoic acid receptor RXR-beta	RXRB	0.0008
2236	Casein kinase II subunit alpha	CSNK2A1	0.0008
172	Potassium channel subfamily K member 1	KCNK1	0.0008
3932	Glutathione S-transferase A2	GSTA2	0.0008
3830	Calreticulin	CALR	0.0008
162	Retinoic acid receptor gamma-1	RARG	0.0008
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0008
6167	Organic solute transporter subunit beta	OSTB	0.0008
6166	Organic solute transporter subunit alpha	OSTA	0.0008
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0008
244	Angiotensin-converting enzyme	ACE	0.0008
6126	Carbonic anhydrase 7	CA7	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
811	Translocator protein	TSPO	0.0008
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0007
581	Cytochrome P450 2R1	CYP2R1	0.0007
822	Aldose reductase	AKR1B1	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0007
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
4773	Deoxycytidine kinase	DCK	0.0007
1992	Vitamin D-binding protein	GC	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
291	Nitric-oxide synthase, endothelial	NOS3	0.0007
251	Alcohol dehydrogenase 1A	ADH1A	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
592	Carbonic anhydrase 4	CA4	0.0006
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
1630	Integrin beta-2	ITGB2	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
444	Alcohol dehydrogenase 1B	ADH1B	0.0006
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0006
6163	Copper-transporting ATPase 2	ATP7B	0.0006
6165	Copper-transporting ATPase 1	ATP7A	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0005
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
798	Osteocalcin	BGLAP	0.0005
856	Vitamin D3 receptor	VDR	0.0005
1039	Histone deacetylase 9	HDAC9	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
572	Integrin alpha-L	ITGAL	0.0005
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0005
357	Carbonic anhydrase 2	CA2	0.0005
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
6824	Tyrosine-protein kinase Lyn	LYN	0.0005
896	Glutathione S-transferase Mu 1	GSTM1	0.0005
6149	Solute carrier family 22 member 10	SLC22A10	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0004
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0004
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0004
1268	Neuropeptide S receptor	NPSR1	0.0004
5787	Angiopoietin-1 receptor	TEK	0.0004
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0004
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0004
24	Thymidylate synthase	TMP1	0.0004
359	Thymidylate synthase	TYMS	0.0004
2626	Thymidylate synthase	thyA	0.0004
2729	Thymidylate synthase	thyA	0.0004
5352	Thymidylate synthase	THYA	0.0004
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0004
6073	Potassium channel subfamily K member 9	KCNK9	0.0004
6072	Potassium channel subfamily K member 3	KCNK3	0.0004
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0004
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0004
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0004
84	Nuclear receptor 0B1	NR0B1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6168	Solute carrier family 22 member 16	SLC22A16	0.0003
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0003
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0003
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0003
469	Annexin A1	ANXA1	0.0003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0003
6085	Fatty acid-binding protein, intestinal	FABP2	0.0003
2207	Rhodopsin	RHO	0.0003
54	Prothrombin	F2	0.0003
76	Nitric-oxide synthase, brain	NOS1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00476 - Duloxetine

Targets

Enzymes

Predictions