DT-Web

DB01208 - Sparfloxacin


Identification
Name Sparfloxacin
Accession Number DB01208 (APRD01231)
Type small molecule
Description Sparfloxacin is a fluoroquinolone antibiotic used in the treatment of bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 392.3998
Groups approved
Monoisotopic Weight 392.165997
Pharmacology
Indication For the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, or Streptococcus pneumoniae) and acute bacterial exacerbations of chronic bronchitis (caused by Chlamydia pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, or Streptococcus pneumoniae).
Mechanism of action The bactericidal action of sparfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
Absorption Well absorbed following oral administration with an absolute oral bioavailability of 92%. Unaffected by administration with milk or food, however concurrent administration of antacids containing magnesium hydroxide and aluminum hydroxide reduces the oral bioavailability of sparfloxacin by as much as 50%.
Protein binding Low plasma protein binding in serum at about 45%.
Biotransformation Hepatic. Metabolized primarily by phase II glucuronidation to form a glucuronide conjugate. Metabolism does not utilize or interfere with the cytochrome P450 enzyme system.
Route of elimination Not Available
Toxicity Single doses of sparfloxacin were relatively non-toxic via the oral route of administration in mice, rats, and dogs. No deaths occurred within a 14-day post-treatment observation period at the highest oral doses tested, up to 5000 mg/kg in either rodent species, or up to 600 mg/kg in the dog. Clinical signs observed included inactivity in mice and dogs, diarrhea in both rodent species, and vomiting, salivation, and tremors in dogs.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiodarone Increased risk of cardiotoxicity and arrhythmias
Amitriptyline Increased risk of cardiotoxicity and arrhythmias
Amoxapine Increased risk of cardiotoxicity and arrhythmias
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Bepridil Increased risk of cardiotoxicity and arrhythmias
Calcium Acetate Calcium salts such as calcium acetate may decrease the absorption of quinolone antibiotics such as sparfloxacin. Of concern only with oral administration of both agents. Interactions can be minimized by administering oral quinolone at least 2 hours before, or 6 hours after, the dose of an oral calcium supplement. Monitor for decreased therapeutic effects of oral quinolones if administered with oral calcium supplements.
Chlorpromazine Increased risk of cardiotoxicity and arrhythmias
Clomipramine Increased risk of cardiotoxicity and arrhythmias
Desipramine Increased risk of cardiotoxicity and arrhythmias
Disopyramide Increased risk of cardiotoxicity and arrhythmias
Doxepin Increased risk of cardiotoxicity and arrhythmias
Erythromycin Increased risk of cardiotoxicity and arrhythmias
Fluphenazine Increased risk of cardiotoxicity and arrhythmias
Imipramine Increased risk of cardiotoxicity and arrhythmias
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Methotrimeprazine Increased risk of cardiotoxicity and arrhythmias
Nortriptyline Increased risk of cardiotoxicity and arrhythmias
Perphenazine Increased risk of cardiotoxicity and arrhythmias
Prochlorperazine Increased risk of cardiotoxicity and arrhythmias
Promethazine Increased risk of cardiotoxicity and arrhythmias
Quinidine Increased risk of cardiotoxicity and arrhythmias
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trifluoperazine Increased risk of cardiotoxicity and arrhythmias
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions Not Available

Targets


DNA topoisomerase 4 subunit A
Name DNA topoisomerase 4 subunit A
Gene Name parC
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Galbraith KM, Ng AC, Eggers BJ, Kuchel CR, Eggers CH, Samuels DS: parC mutations in fluoroquinolone-resistant Borrelia burgdorferi. Antimicrob Agents Chemother. 2005 Oct;49(10):4354-7. - Pubmed
  • Oyamada Y, Ito H, Fujimoto K, Asada R, Niga T, Okamoto R, Inoue M, Yamagishi J: Combination of known and unknown mechanisms confers high-level resistance to fluoroquinolones in Enterococcus faecium. J Med Microbiol. 2006 Jun;55(Pt 6):729-36. - Pubmed
  • Pan XS, Yague G, Fisher LM: Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins. Antimicrob Agents Chemother. 2001 Nov;45(11):3140-7. - Pubmed
DTHybrid score 0.9188
DNA gyrase subunit A
Name DNA gyrase subunit A
Gene Name gyrA
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Schmitz FJ, Hofmann B, Hansen B, Scheuring S, Luckefahr M, Klootwijk M, Verhoef J, Fluit A, Heinz HP, Kohrer K, Jones ME: Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus. J Antimicrob Chemother. 1998 Apr;41(4):481-4. - Pubmed
  • Taba H, Kusano N: Sparfloxacin resistance in clinical isolates of Streptococcus pneumoniae: involvement of multiple mutations in gyrA and parC genes. Antimicrob Agents Chemother. 1998 Sep;42(9):2193-6. - Pubmed
  • Fukuda H, Hori S, Hiramatsu K: Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother. 1998 Aug;42(8):1917-22. - Pubmed
DTHybrid score 0.9536
DNA topoisomerase 2-alpha
Name DNA topoisomerase 2-alpha
Gene Name TOP2A
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7369

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score 0.2931
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Sasabe H, Tsuji A, Sugiyama Y: Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. J Pharmacol Exp Ther. 1998 Mar;284(3):1033-9. - Pubmed
DTHybrid score 0.2593
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Naruhashi K, Tamai I, Inoue N, Muraoka H, Sai Y, Suzuki N, Tsuji A: Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein. J Pharm Pharmacol. 2001 May;53(5):699-709. - Pubmed
  • Cormet-Boyaka E, Huneau JF, Mordrelle A, Boyaka PN, Carbon C, Rubinstein E, Tome D: Secretion of sparfloxacin from the human intestinal Caco-2 cell line is altered by P-glycoprotein inhibitors. Antimicrob Agents Chemother. 1998 Oct;42(10):2607-11. - Pubmed
DTHybrid score 0.3279

Predictions


Id Partner name Gene Name Score
6224 DNA gyrase subunit A gyrA 0.9536
886 DNA topoisomerase 4 subunit A parC 0.9188
6226 DNA topoisomerase 4 subunit A parC 0.9188
4200 Cytochrome P450 1A2 CYP1A2 0.2307
4512 Cytochrome P450 3A4 CYP3A4 0.1695
1729 Solute carrier family 22 member 6 SLC22A6 0.1207
862 Multidrug resistance-associated protein 1 ABCC1 0.1151
4118 Cytochrome P450 3A5 CYP3A5 0.0972
833 Organic cation/carnitine transporter 1 SLC22A4 0.0897
4119 Cytochrome P450 2D6 CYP2D6 0.089
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0791
6144 Solute carrier family 22 member 2 SLC22A2 0.0763
6107 Cytochrome P450 3A7 CYP3A7 0.074
4757 Cytochrome P450 2C9 CYP2C9 0.068
6016 Cytochrome P450 2C19 CYP2C19 0.0587
4924 Cytochrome P450 2C8 CYP2C8 0.055
6145 Solute carrier family 22 member 1 SLC22A1 0.05
4192 DNA topoisomerase 2-beta TOP2B 0.0477
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0467
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0427
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.042
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0416
6024 Cytochrome P450 1A1 CYP1A1 0.0411
776 Bile salt export pump ABCB11 0.038
6030 Cytochrome P450 2B6 CYP2B6 0.0379
6142 Solute carrier family 22 member 8 SLC22A8 0.0366
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0365
6137 Multidrug resistance-associated protein 6 ABCC6 0.0363
5718 Cytochrome P450 2A6 CYP2A6 0.0334
587 Serum albumin ALB 0.0331
4180 DNA-(apurinic or apyrimidinic site) lyase APEX1 0.0305
6147 Solute carrier family 22 member 3 SLC22A3 0.0303
6013 Cytochrome P450 2E1 CYP2E1 0.0296
1353 DNA topoisomerase 1 TOP1 0.0266
3552 DNA topoisomerase 1 topA 0.0266
2164 Multidrug resistance-associated protein 4 ABCC4 0.0264
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0255
1898 Cytochrome P450 1B1 CYP1B1 0.0251
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0248
6148 Multidrug resistance-associated protein 7 ABCC10 0.0243
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0229
1024 Solute carrier family 22 member 11 SLC22A11 0.0219
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0207
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0192
136 Estrogen receptor ESR1 0.0191
161 Tubulin beta chain TUBB 0.0191
312 Tubulin beta chain TUB2 0.0191
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0188
70 Type-1 angiotensin II receptor AGTR1 0.0186
6143 Solute carrier family 22 member 7 SLC22A7 0.0179
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0171
492 Histamine H1 receptor HRH1 0.0168
738 Monocarboxylate transporter 1 SLC16A1 0.0167
2539 Tubulin alpha-1 chain TUBA4A 0.0162
6141 Sodium/bile acid cotransporter SLC10A1 0.0161
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0156
13 Aminomethyltransferase, mitochondrial AMT 0.0154
159 Penicillin-binding protein 2B penA 0.0153
6121 Penicillin-binding protein 2B penA 0.0153
20 Prostaglandin G/H synthase 1 PTGS1 0.0148
556 Alpha-1A adrenergic receptor ADRA1A 0.0139
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0134
3923 Cholinesterase BCHE 0.0133
6106 Cytochrome P450 2C18 CYP2C18 0.0132
193 Beta-1 adrenergic receptor ADRB1 0.0129
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0127
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0126
824 Sodium-dependent serotonin transporter SLC6A4 0.0125
723 Cytosolic phospholipase A2 PLA2G4A 0.0124
3947 Xanthine dehydrogenase/oxidase XDH 0.0121
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.012
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0118
4120 NADPH--cytochrome P450 reductase POR 0.0116
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0116
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0115
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0115
4604 Liver carboxylesterase 1 CES1 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
2443 Azurin azu 0.0108
766 Beta-2 adrenergic receptor ADRB2 0.0106
871 Glucocorticoid receptor NR3C1 0.0105
614 Progesterone receptor PGR 0.0104
633 Penicillin-binding proteins 1A/1B pbpA 0.0104
318 Alpha-2A adrenergic receptor ADRA2A 0.0104
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0103
474 Acetylcholinesterase ACHE 0.0102
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0101
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0101
131 Synaptic vesicular amine transporter SLC18A2 0.01
908 Glutathione S-transferase theta-1 GSTT1 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0098
831 D(2) dopamine receptor DRD2 0.0098
1757 Myeloperoxidase MPO 0.0097
290 Prostaglandin G/H synthase 2 PTGS2 0.0097
737 Mineralocorticoid receptor NR3C2 0.0096
185 Vasopressin V1a receptor AVPR1A 0.0096
629 Alpha-2B adrenergic receptor ADRA2B 0.0094
322 Vasopressin V2 receptor AVPR2 0.0093
6136 Multidrug resistance-associated protein 5 ABCC5 0.0091
869 Estrogen receptor beta ESR2 0.009
731 HIV-1 protease HIV-1 protease 0.009
3811 Cytochrome P450 19A1 CYP19A1 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0088
904 Glutathione S-transferase P GSTP1 0.0086
632 Alpha-1B adrenergic receptor ADRA1B 0.0086
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
713 Sodium-dependent dopamine transporter SLC6A3 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
789 Alpha-1D adrenergic receptor ADRA1D 0.0081
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
380 Cytochrome P450 17A1 CYP17A1 0.008
124 Histamine H2 receptor HRH2 0.0078
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
24 Thymidylate synthase TMP1 0.0075
359 Thymidylate synthase TYMS 0.0075
2626 Thymidylate synthase thyA 0.0075
2729 Thymidylate synthase thyA 0.0075
5352 Thymidylate synthase THYA 0.0075
992 Protein tyrosine kinase 2 beta PTK2B 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
645 Penicillin-binding protein 1A mrcA 0.0073
5805 Penicillin-binding protein 1A ponA 0.0073
6185 Penicillin-binding protein 1A mrcA 0.0073
6799 Penicillin-binding protein 1A pbpA 0.0073
502 5-hydroxytryptamine 2A receptor HTR2A 0.0072
2417 Chloramphenicol acetyltransferase cat 0.0071
3278 Chloramphenicol acetyltransferase cat 0.0071
3941 Amine oxidase [flavin-containing] A MAOA 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
6168 Solute carrier family 22 member 16 SLC22A16 0.0071
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.007
378 Alpha-2C adrenergic receptor ADRA2C 0.007
844 Epidermal growth factor receptor EGFR 0.007
3939 Amine oxidase [flavin-containing] B MAOB 0.0069
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0069
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0067
1192 Sulfotransferase 1A1 SULT1A1 0.0066
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0065
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0064
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
275 Arachidonate 5-lipoxygenase ALOX5 0.0063
3270 Elongation factor G fusA 0.0062
373 Transthyretin TTR 0.0061
504 Mast/stem cell growth factor receptor KIT 0.0061
2808 Chloramphenicol acetyltransferase 3 cat3 0.0061
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0059
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
26 Vascular endothelial growth factor receptor 3 FLT4 0.0059
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0059
23 D(1A) dopamine receptor DRD1 0.0059
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0059
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0059
6067 Penicillin binding protein 2a mecA 0.0058
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0057
788 Creatine kinase M-type CKM 0.0057
32 Vascular endothelial growth factor receptor 1 FLT1 0.0057
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0057
1852 Microtubule-associated protein 2 MAP2 0.0056
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0056
777 Tumor necrosis factor TNF 0.0056
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0055
7 Nitric oxide synthase, inducible NOS2 0.0055
1629 Transcription factor AP-1 JUN 0.0055
465 Calmodulin CALM1 0.0055
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0054
260 Cytochrome P450 51 ERG11 0.0054
761 Cytochrome P450 51 ERG11 0.0054
3163 Cytochrome P450 51 cyp51 0.0054
5626 Nucleoside diphosphate kinase B NME2 0.0054
468 Cytochrome P450 4A11 CYP4A11 0.0053
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0053
228 Beta platelet-derived growth factor receptor PDGFRB 0.0053
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0053
2449 Tubulin alpha-3 chain TUBA1A 0.0052
6182 Cytochrome P450 2J2 CYP2J2 0.0052
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0052
29 Tubulin beta-1 chain TUBB1 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0051
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.005
6228 Nuclear receptor coactivator 1 NCOA1 0.005
320 5-hydroxytryptamine 1A receptor HTR1A 0.005
6163 Copper-transporting ATPase 2 ATP7B 0.005
6165 Copper-transporting ATPase 1 ATP7A 0.005
6149 Solute carrier family 22 member 10 SLC22A10 0.0049
6241 Nuclear receptor coactivator 2 NCOA2 0.0049
407 Vascular endothelial growth factor receptor 2 KDR 0.0049
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0049
146 Androgen receptor AR 0.0048
558 Solute carrier family 12 member 1 SLC12A1 0.0048
847 Mu-type opioid receptor OPRM1 0.0048
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
461 Glycine receptor subunit alpha-3 GLRA3 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0046
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0046
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0045
896 Glutathione S-transferase Mu 1 GSTM1 0.0045
291 Nitric-oxide synthase, endothelial NOS3 0.0045
165 FL cytokine receptor FLT3 0.0044
5923 Microtubule-associated protein tau MAPT 0.0044
5924 Microtubule-associated protein 4 MAP4 0.0044
952 Dipeptidyl peptidase 4 DPP4 0.0044
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0044
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0044
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0044
5294 Nucleoside diphosphate kinase A NME1 0.0044
467 Delta-type opioid receptor OPRD1 0.0043
638 D(3) dopamine receptor DRD3 0.0043
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0043
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0043
273 Apoptosis regulator Bcl-2 BCL2 0.0042
6599 HTH-type transcriptional regulator ttgR ttgR 0.0041
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0041
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0041
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
696 Kappa-type opioid receptor OPRK1 0.004
6085 Fatty acid-binding protein, intestinal FABP2 0.0039
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0039
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0039
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0038
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0038
885 5-hydroxytryptamine 1B receptor HTR1B 0.0038
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0038
725 5-hydroxytryptamine 1D receptor HTR1D 0.0038
740 Argininosuccinate synthase ASS1 0.0038
865 Argininosuccinate synthase ASS1 0.0038
2680 Argininosuccinate synthase argG 0.0038
3194 Argininosuccinate synthase argG 0.0038
2232 Interleukin-5 IL5 0.0037
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0037
1593 Mucin-2 MUC2 0.0037
489 Monocarboxylate transporter 2 SLC16A7 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0037
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0037
122 P2Y purinoceptor 12 P2RY12 0.0036
4203 Histamine N-methyltransferase HNMT 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
5126 Arginase rocF 0.0036
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0036
1569 G1/S-specific cyclin-D1 CCND1 0.0036
1650 Heme carrier protein 1 SLC46A1 0.0036
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
164 Histamine H4 receptor HRH4 0.0035
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0035
6218 Pannexin-1 PANX1 0.0034
1341 Histamine H3 receptor HRH3 0.0034
1760 Aminopeptidase N ANPEP 0.0034
6843 Aminopeptidase N pepN 0.0034
357 Carbonic anhydrase 2 CA2 0.0033
751 Potassium channel subfamily K member 6 KCNK6 0.0033
1517 Beta-3 adrenergic receptor ADRB3 0.0033
117 Sterol O-acyltransferase 1 SOAT1 0.0033
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0033
6167 Organic solute transporter subunit beta OSTB 0.0033
6166 Organic solute transporter subunit alpha OSTA 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
33 Cystine/glutamate transporter SLC7A11 0.0033
499 Arginine decarboxylase ADC 0.0033
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0032
6211 Tubulin epsilon chain TUBE1 0.0032
6210 Tubulin delta chain TUBD1 0.0032
6212 Tubulin gamma-1 chain TUBG1 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
976 Platelet glycoprotein IX GP9 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
2300 Lysozyme E 0.0032
3633 Lysozyme R 0.0032
5597 Lysozyme 17 0.0032
2499 Tubulin beta-2C chain TUBB2C 0.0031
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
702 UMP-CMP kinase CMPK1 0.0031
6031 Cytochrome P450 3A43 CYP3A43 0.0031
577 Argininosuccinate lyase ASL 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
172 Potassium channel subfamily K member 1 KCNK1 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
756 Sex hormone-binding globulin SHBG 0.003
3810 Catechol O-methyltransferase COMT 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
590 5-hydroxytryptamine 2C receptor HTR2C 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
1714 Mitogen-activated protein kinase 3 MAPK3 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0029
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0029
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0029
683 Potassium transporter GK0582 0.0029
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0029
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0028
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0027
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0027
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0027
76 Nitric-oxide synthase, brain NOS1 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
3587 Gastrotropin FABP6 0.0026
818 50S ribosomal protein L10 rplJ 0.0026
1630 Integrin beta-2 ITGB2 0.0026
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0026
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0026
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0026
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0026
6837 Serine/threonine-protein kinase 17B STK17B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6151 Monocarboxylate transporter 10 SLC16A10 0.0026
4773 Deoxycytidine kinase DCK 0.0026
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0025
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0025
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0024
432 D(4) dopamine receptor DRD4 0.0024
342 P protein [Includes: DNA-directed DNA polymerase P 0.0024
612 P protein [Includes: DNA-directed DNA polymerase P 0.0024
6432 Transporter snf 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
1176 Mitogen-activated protein kinase 1 MAPK1 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0023
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0023
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0023
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0023
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0023
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0023
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
469 Annexin A1 ANXA1 0.0021
6044 Serum paraoxonase/lactonase 3 PON3 0.0021
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0021
3917 Methylenetetrahydrofolate reductase MTHFR 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
163 D(1B) dopamine receptor DRD5 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.002
5682 Ribonuclease pancreatic RNASE1 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
1656 CYP2B protein CYP2B 0.002
1360 Sphingomyelin phosphodiesterase SMPD1 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
572 Integrin alpha-L ITGAL 0.002
3868 Calcineurin subunit B isoform 2 PPP3R2 0.002
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0019
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0019
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0019
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
365 Dihydrofolate reductase DHFR 0.0019
2381 Dihydrofolate reductase DFR1 0.0019
2833 Dihydrofolate reductase Not Available 0.0019
2931 Dihydrofolate reductase folA 0.0019
3544 Dihydrofolate reductase folA 0.0019
3682 Dihydrofolate reductase folA 0.0019
6642 Dihydrofolate reductase folA 0.0019
6756 Dihydrofolate reductase dfrA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0019
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0019
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0019
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
4122 Histone deacetylase 2 HDAC2 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
1039 Histone deacetylase 9 HDAC9 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
1313 Lactoylglutathione lyase GLO1 0.0017
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0017
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0016
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
3809 Estrogen-related receptor gamma ESRRG 0.0016
484 Tyrosine-protein kinase ABL2 ABL2 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0015
6014 Cytochrome P450 2A13 CYP2A13 0.0015
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
6755 Poliovirus receptor PVR 0.0015
5818 Folate receptor alpha FOLR1 0.0015
6220 Aryl hydrocarbon receptor AHR 0.0015
6042 Prostaglandin reductase 2 PTGR2 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
84 Nuclear receptor 0B1 NR0B1 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
6043 Putative G-protein coupled receptor 44 GPR44 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
3932 Glutathione S-transferase A2 GSTA2 0.0014
2981 Phospholipase A2, membrane associated PLA2G2A 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
284 DNA-directed RNA polymerase beta chain rpoB 0.0013
5773 DNA-directed RNA polymerase beta chain rpoB 0.0013
293 Gamma-glutamyl hydrolase GGH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
694 Matrix protein 2 M 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
292 Activin receptor type-1 ACVR1 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
2540 Choloylglycine hydrolase cbh 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
6459 Glycodelin PAEP 0.0011
1618 High affinity nerve growth factor receptor NTRK1 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
6501 Fatty acid-binding protein, liver FABP1 0.0011
427 Substance-P receptor TACR1 0.0011
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
3957 Adenosine deaminase ADA 0.0009
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
6020 Aldehyde oxidase AOX1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
6500 Phospholipase A2 PLA2G1B 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
54 Prothrombin F2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
5787 Angiopoietin-1 receptor TEK 0.0008
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
823 Fibroblast growth factor receptor 2 FGFR2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0008
229 Retinoic acid receptor beta RARB 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
921 Glutamate receptor 2 GRIA2 0.0007
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0006
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0006
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
341 5-hydroxytryptamine 3 receptor HTR3A 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2021 Thrombomodulin THBD 0.0005
2207 Rhodopsin RHO 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0003
295 Carbonic anhydrase 1 CA1 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
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