DT-Web

DB01069 - Promethazine


Identification
Name Promethazine
Accession Number DB01069 (APRD00601)
Type small molecule
Description A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 284.419
Groups approved
Monoisotopic Weight 284.13471934
Pharmacology
Indication For the treatment of allergic disorders, and nausea/vomiting.
Mechanism of action Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone.
Absorption On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Protein binding 93%
Biotransformation Hepatic
Route of elimination Promethazine hydrochloride is metabolized in the liver, with the sulfoxides of promethazine and N-desmethylpromethazine being the predominant metabolites appearing in the urine.
Toxicity Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amphetamine Decreased anorexic effect, may increase pyschotic symptoms
Benzphetamine Antipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Cisapride Increased risk of cardiotoxicity and arrhythmias
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dexfenfluramine Decreased anorexic effect, may increase pyschotic symptoms.
Dextroamphetamine Decreased anorexic effect, may increase pyschotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms.
Donepezil Possible antagonism of action
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms.
Galantamine Possible antagonism of action
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine Promethazine may decrease the effect of guanethidine.
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Mazindol Decreased anorexic effect, may increase psychotic symptoms.
Methamphetamine Decreased anorexic effect, may increase pyschotic symptoms
Metrizamide Increased risk of convulsions
Phendimetrazine Decreased anorexic effect, may increase pyschotic symptoms
Phenmetrazine Decreased anorexic effect, may increase pyschotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms.
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms.
Rivastigmine Possible antagonism of action
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Promethazine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Terbinafine Terbinafine may reduce the metabolism and clearance of Promethazine. Consider alternate therapy or monitor for therapeutic/adverse effects of Promethazine if Terbinafine is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thiotepa Thiotepa, a strong CYP2B6 inhibitor, may decrease the metabolism and clearance of Promethazine, a CYP2B6 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Promethazine if Thiotepa is initiated, discontinued or dose changed.
Tramadol Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimethobenzamide Trimethobenzamide and Promethazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Triprolidine Triprolidine and Promethazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trospium Trospium and Promethazine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Zolmitriptan Use of two serotonin modulators, such as zolmitriptan and promethazine, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Food Interactions
  • Take with food to reduce irritation. Avoid alcohol.

Targets


Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Suzuki A, Yasui-Furukori N, Mihara K, Kondo T, Furukori H, Inoue Y, Kaneko S, Otani K: Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. Ther Drug Monit. 2003 Apr;25(2):192-6. - Pubmed
  • Smith BN, Armstrong WE: Histamine enhances the depolarizing afterpotential of immunohistochemically identified vasopressin neurons in the rat supraoptic nucleus via H1-receptor activation. Neuroscience. 1993 Apr;53(3):855-64. - Pubmed
  • Miller RA, Tu AT: Factors in snake venoms that increase capillary permeability. J Pharm Pharmacol. 1989 Nov;41(11):792-4. - Pubmed
  • Claro E, Arbones L, Garcia A, Picatoste F: Phosphoinositide hydrolysis mediated by histamine H1-receptors in rat brain cortex. Eur J Pharmacol. 1986 Apr 16;123(2):187-96. - Pubmed
  • Ikeda H, Kubo N, Nakamura A, Harada N, Minamino M, Yamashita T: Histamine-induced calcium released from cultured human mucosal microvascular endothelial cells from nasal inferior turbinate. Acta Otolaryngol. 1997 Nov;117(6):864-70. - Pubmed
  • Paton DM, Webster DR: Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet. 1985 Nov-Dec;10(6):477-97. - Pubmed
DTHybrid score 0.7447
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action unknown
Actions antagonist
References
  • Golembiewski JA, O'Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. - Pubmed
DTHybrid score 0.4723
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action unknown
Actions antagonist
References
  • Golembiewski JA, O'Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. - Pubmed
DTHybrid score 0.9934
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action unknown
Actions antagonist
References
  • Golembiewski JA, O'Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. - Pubmed
DTHybrid score 0.8406
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action unknown
Actions antagonist
References
  • Golembiewski JA, O'Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. - Pubmed
DTHybrid score 0.8395
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action unknown
Actions antagonist
References
  • Golembiewski JA, O'Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. - Pubmed
DTHybrid score 0.6162
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action unknown
Actions antagonist
References
  • Golembiewski JA, O'Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. - Pubmed
DTHybrid score 0.5181
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action unknown
Actions unknown
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4947
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action unknown
Actions antagonist
References
  • Bileviciute I, Stenfors C, Theodorsson E, Lundeberg T: Unilateral injection of calcitonin gene-related peptide (CGRP) induces bilateral oedema formation and release of CGRP-like immunoreactivity in the rat hindpaw. Br J Pharmacol. 1998 Nov;125(6):1304-12. - Pubmed
  • Kelley BM, Porter JH: The role of muscarinic cholinergic receptors in the discriminative stimulus properties of clozapine in rats. Pharmacol Biochem Behav. 1997 Aug;57(4):707-19. - Pubmed
  • Hoenicke EM, Vanecek SA, Woods JH: The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. J Pharmacol Exp Ther. 1992 Oct;263(1):276-84. - Pubmed
  • Martinez F, Coleman JW: A comparison of the effects of chlorpromazine and more selective histamine and 5-hydroxytryptamine antagonists on human IgG synthesis in vitro. Int J Immunopharmacol. 1990;12(2):185-91. - Pubmed
  • Fiorella D, Rabin RA, Winter JC: The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56. - Pubmed
DTHybrid score 0.4282
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions inhibitor
References
  • Cohen ME, Sharp GW, Donowitz M: Suggestion of a role for calmodulin and phosphorylation in regulation of rabbit ileal electrolyte transport: effects of promethazine. Am J Physiol. 1986 Nov;251(5 Pt 1):G710-7. - Pubmed
  • Scott JA, Khaw BA, Fallon JT, Locke E, Rabito CA, Peto CA, Homcy CJ: The effect of phenothiazines upon maintenance of membrane integrity in the cultured myocardial cell. J Mol Cell Cardiol. 1986 Dec;18(12):1243-54. - Pubmed
  • Lohr KM, Feix JB, Kurth C: Chlorpromazine inhibits neutrophil chemotaxis beyond the chemotactic receptor-ligand interaction. J Infect Dis. 1984 Nov;150(5):643-52. - Pubmed
  • DiPaola M, Keith CH, Feldman D, Tycko B, Maxfield FR: Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides. J Cell Physiol. 1984 Feb;118(2):193-202. - Pubmed
  • Luchowski EM, Yousif F, Triggle DJ, Maurer SC, Sarmiento JG, Janis RA: Effects of metal cations and calmodulin antagonists on [3H] nitrendipine binding in smooth and cardiac muscle. J Pharmacol Exp Ther. 1984 Sep;230(3):607-13. - Pubmed
DTHybrid score 0.4262

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Platts SH, Shi SJ, Meck JV: Akathisia with combined use of midodrine and promethazine. JAMA. 2006 May 3;295(17):2000-1. - Pubmed
DTHybrid score 0.6978
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3351
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.423

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. - Pubmed
DTHybrid score 0.4733

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.5338
4200 Cytochrome P450 1A2 CYP1A2 0.3138
6016 Cytochrome P450 2C19 CYP2C19 0.2969
23 D(1A) dopamine receptor DRD1 0.256
4924 Cytochrome P450 2C8 CYP2C8 0.2217
318 Alpha-2A adrenergic receptor ADRA2A 0.2111
632 Alpha-1B adrenergic receptor ADRA1B 0.2052
590 5-hydroxytryptamine 2C receptor HTR2C 0.2021
4118 Cytochrome P450 3A5 CYP3A5 0.1866
6013 Cytochrome P450 2E1 CYP2E1 0.1764
320 5-hydroxytryptamine 1A receptor HTR1A 0.1706
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1634
638 D(3) dopamine receptor DRD3 0.1478
824 Sodium-dependent serotonin transporter SLC6A4 0.1449
789 Alpha-1D adrenergic receptor ADRA1D 0.1448
6107 Cytochrome P450 3A7 CYP3A7 0.1384
432 D(4) dopamine receptor DRD4 0.1341
3923 Cholinesterase BCHE 0.1259
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1206
629 Alpha-2B adrenergic receptor ADRA2B 0.1153
378 Alpha-2C adrenergic receptor ADRA2C 0.1124
587 Serum albumin ALB 0.0981
5718 Cytochrome P450 2A6 CYP2A6 0.0979
6145 Solute carrier family 22 member 1 SLC22A1 0.0967
6024 Cytochrome P450 1A1 CYP1A1 0.0931
716 5-hydroxytryptamine 7 receptor HTR7 0.0892
163 D(1B) dopamine receptor DRD5 0.0876
436 5-hydroxytryptamine 2B receptor HTR2B 0.0858
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0849
713 Sodium-dependent dopamine transporter SLC6A3 0.0806
725 5-hydroxytryptamine 1D receptor HTR1D 0.0771
885 5-hydroxytryptamine 1B receptor HTR1B 0.0728
1256 5-hydroxytryptamine 6 receptor HTR6 0.0706
6144 Solute carrier family 22 member 2 SLC22A2 0.0676
20 Prostaglandin G/H synthase 1 PTGS1 0.063
766 Beta-2 adrenergic receptor ADRB2 0.062
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0619
341 5-hydroxytryptamine 3 receptor HTR3A 0.061
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0596
6106 Cytochrome P450 2C18 CYP2C18 0.0574
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0557
193 Beta-1 adrenergic receptor ADRB1 0.0553
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.055
118 Organic cation/carnitine transporter 2 SLC22A5 0.0522
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0492
528 5-hydroxytryptamine 1E receptor HTR1E 0.048
833 Organic cation/carnitine transporter 1 SLC22A4 0.0477
131 Synaptic vesicular amine transporter SLC18A2 0.0459
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0438
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0417
124 Histamine H2 receptor HRH2 0.0413
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0387
6147 Solute carrier family 22 member 3 SLC22A3 0.0381
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0373
3941 Amine oxidase [flavin-containing] A MAOA 0.037
1507 Cytochrome c CYCS 0.0362
862 Multidrug resistance-associated protein 1 ABCC1 0.036
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0353
722 Troponin I, cardiac muscle TNNI3 0.0347
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.034
696 Kappa-type opioid receptor OPRK1 0.0338
2129 Sucrase-isomaltase, intestinal SI 0.0331
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0326
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0315
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0311
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0311
467 Delta-type opioid receptor OPRD1 0.0309
847 Mu-type opioid receptor OPRM1 0.0296
174 Sigma 1-type opioid receptor SIGMAR1 0.0296
1898 Cytochrome P450 1B1 CYP1B1 0.0295
1656 CYP2B protein CYP2B 0.0295
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0294
94 5-hydroxytryptamine 4 receptor HTR4 0.029
474 Acetylcholinesterase ACHE 0.0286
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0283
1729 Solute carrier family 22 member 6 SLC22A6 0.0281
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0281
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.028
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0276
290 Prostaglandin G/H synthase 2 PTGS2 0.0268
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0267
776 Bile salt export pump ABCB11 0.0257
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0256
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0251
3811 Cytochrome P450 19A1 CYP19A1 0.0249
6432 Transporter snf 0.0248
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0246
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0237
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0228
3939 Amine oxidase [flavin-containing] B MAOB 0.0228
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0225
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0224
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0221
136 Estrogen receptor ESR1 0.022
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0214
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0209
731 HIV-1 protease HIV-1 protease 0.0206
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0205
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0205
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0204
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0199
6182 Cytochrome P450 2J2 CYP2J2 0.0199
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0197
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0196
1341 Histamine H3 receptor HRH3 0.0193
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0186
6142 Solute carrier family 22 member 8 SLC22A8 0.0183
6859 Protein S100-A4 S100A4 0.0182
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0179
122 P2Y purinoceptor 12 P2RY12 0.0178
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0178
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0177
6048 Troponin C, skeletal muscle TNNC2 0.0174
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0173
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0171
516 Neurotensin receptor type 2 NTSR2 0.0168
1089 Cartilage oligomeric matrix protein COMP 0.0168
1108 Calpastatin CAST 0.0168
2164 Multidrug resistance-associated protein 4 ABCC4 0.016
891 Dihydropteroate synthase folP 0.0153
5359 Dihydropteroate synthase folP 0.0153
7175 Dihydropteroate synthase sulI 0.0153
4120 NADPH--cytochrome P450 reductase POR 0.0153
380 Cytochrome P450 17A1 CYP17A1 0.0151
923 Glutamate receptor 3 GRIA3 0.0149
1360 Sphingomyelin phosphodiesterase SMPD1 0.0147
3947 Xanthine dehydrogenase/oxidase XDH 0.0147
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0144
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0138
164 Histamine H4 receptor HRH4 0.0137
2132 Protein S100-B S100B 0.0136
6143 Solute carrier family 22 member 7 SLC22A7 0.0135
468 Cytochrome P450 4A11 CYP4A11 0.0134
723 Cytosolic phospholipase A2 PLA2G4A 0.0134
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0134
260 Cytochrome P450 51 ERG11 0.0134
761 Cytochrome P450 51 ERG11 0.0134
3163 Cytochrome P450 51 cyp51 0.0134
482 Glycine receptor subunit alpha-1 GLRA1 0.0133
1618 High affinity nerve growth factor receptor NTRK1 0.0132
1275 Estrogen sulfotransferase SULT1E1 0.013
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0129
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0129
921 Glutamate receptor 2 GRIA2 0.0129
817 DNA topoisomerase 2-alpha TOP2A 0.0128
871 Glucocorticoid receptor NR3C1 0.0124
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0119
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0119
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0119
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0118
2795 Methionine aminopeptidase 2 METAP2 0.0117
4604 Liver carboxylesterase 1 CES1 0.0116
537 ATP synthase delta chain, mitochondrial ATP5D 0.0114
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0114
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.011
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0109
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0108
705 Glutamate receptor 1 GRIA1 0.0107
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0106
504 Mast/stem cell growth factor receptor KIT 0.0106
5682 Ribonuclease pancreatic RNASE1 0.0104
146 Androgen receptor AR 0.0103
70 Type-1 angiotensin II receptor AGTR1 0.0103
6137 Multidrug resistance-associated protein 6 ABCC6 0.0102
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0101
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0101
6138 Multidrug resistance protein 3 ABCB4 0.01
1262 Corticotropin-lipotropin POMC 0.0098
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0095
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0094
6136 Multidrug resistance-associated protein 5 ABCC5 0.0093
6031 Cytochrome P450 3A43 CYP3A43 0.0092
844 Epidermal growth factor receptor EGFR 0.0092
427 Substance-P receptor TACR1 0.0091
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0091
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0088
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0086
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0086
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0086
161 Tubulin beta chain TUBB 0.0085
312 Tubulin beta chain TUB2 0.0085
869 Estrogen receptor beta ESR2 0.0085
1024 Solute carrier family 22 member 11 SLC22A11 0.0084
1757 Myeloperoxidase MPO 0.0083
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0081
3426 Glutamine synthetase glnA 0.008
3987 Glutamine synthetase GLUL 0.008
1192 Sulfotransferase 1A1 SULT1A1 0.008
6148 Multidrug resistance-associated protein 7 ABCC10 0.0077
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0076
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0073
6141 Sodium/bile acid cotransporter SLC10A1 0.0073
6085 Fatty acid-binding protein, intestinal FABP2 0.0073
6220 Aryl hydrocarbon receptor AHR 0.0073
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0073
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0072
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0072
244 Angiotensin-converting enzyme ACE 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
1636 Trace amine-associated receptor 1 TAAR1 0.0071
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.007
407 Vascular endothelial growth factor receptor 2 KDR 0.007
4203 Histamine N-methyltransferase HNMT 0.007
3810 Catechol O-methyltransferase COMT 0.0069
362 Melatonin receptor type 1B MTNR1B 0.0069
571 Melatonin receptor type 1A MTNR1A 0.0069
737 Mineralocorticoid receptor NR3C2 0.0068
756 Sex hormone-binding globulin SHBG 0.0068
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0068
614 Progesterone receptor PGR 0.0065
1010 Cytochrome P450 51A1 CYP51A1 0.0065
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0065
952 Dipeptidyl peptidase 4 DPP4 0.0065
365 Dihydrofolate reductase DHFR 0.0064
2381 Dihydrofolate reductase DFR1 0.0064
2833 Dihydrofolate reductase Not Available 0.0064
2931 Dihydrofolate reductase folA 0.0064
3544 Dihydrofolate reductase folA 0.0064
3682 Dihydrofolate reductase folA 0.0064
6642 Dihydrofolate reductase folA 0.0064
6756 Dihydrofolate reductase dfrA 0.0064
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0064
2616 Ganglioside GM2 activator GM2A 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
228 Beta platelet-derived growth factor receptor PDGFRB 0.0063
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0062
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
26 Vascular endothelial growth factor receptor 3 FLT4 0.0062
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0062
1517 Beta-3 adrenergic receptor ADRB3 0.0061
3830 Calreticulin CALR 0.0061
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0061
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0061
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0061
811 Translocator protein TSPO 0.006
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.006
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.006
1353 DNA topoisomerase 1 TOP1 0.0059
3552 DNA topoisomerase 1 topA 0.0059
32 Vascular endothelial growth factor receptor 1 FLT1 0.0059
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0059
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0059
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0059
818 50S ribosomal protein L10 rplJ 0.0059
738 Monocarboxylate transporter 1 SLC16A1 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0058
6035 Nuclear receptor ROR-beta RORB 0.0057
6034 Hydroxyindole O-methyltransferase ASMT 0.0057
6036 Eosinophil peroxidase EPX 0.0057
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0057
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0057
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0057
2112 Toll-like receptor 9 TLR9 0.0055
777 Tumor necrosis factor TNF 0.0055
295 Carbonic anhydrase 1 CA1 0.0055
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0054
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0054
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0054
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0054
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0054
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0054
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0053
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0053
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0053
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0053
319 Opioid receptor, sigma 1 OPRS1 0.0052
828 Phenylalanine-4-hydroxylase PAH 0.0052
3109 Phenylalanine-4-hydroxylase phhA 0.0052
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0052
29 Tubulin beta-1 chain TUBB1 0.0051
694 Matrix protein 2 M 0.0051
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0051
6097 Protein S100-A2 S100A2 0.005
765 Indoleamine 2,3-dioxygenase IDO1 0.005
1810 Protein S100-A1 S100A1 0.005
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0049
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0049
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0049
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0049
183 Vascular endothelial growth factor A VEGFA 0.0049
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0048
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
373 Transthyretin TTR 0.0048
24 Thymidylate synthase TMP1 0.0047
359 Thymidylate synthase TYMS 0.0047
2626 Thymidylate synthase thyA 0.0047
2729 Thymidylate synthase thyA 0.0047
5352 Thymidylate synthase THYA 0.0047
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
904 Glutathione S-transferase P GSTP1 0.0044
49 Endothelin B receptor EDNRB 0.0044
6014 Cytochrome P450 2A13 CYP2A13 0.0043
6102 Arylamine N-acetyltransferase 2 NAT2 0.0043
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0043
1048 Protein S100-A13 S100A13 0.0043
2226 Protein S100-A12 S100A12 0.0043
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0042
1178 Adenosine A2a receptor ADORA2A 0.0042
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0042
592 Carbonic anhydrase 4 CA4 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
6151 Monocarboxylate transporter 10 SLC16A10 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
1629 Transcription factor AP-1 JUN 0.004
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.004
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.004
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.004
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.004
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.004
153 Dopamine beta-hydroxylase DBH 0.0039
1374 Natriuretic peptides B NPPB 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
1827 Gap junction alpha-1 protein GJA1 0.0038
1908 Vascular cell adhesion protein 1 VCAM1 0.0038
563 Thyroid peroxidase TPO 0.0038
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0038
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0038
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0038
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0037
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0037
780 Retinoic acid receptor RXR-gamma RXRG 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0037
130 Prostacyclin synthase PTGIS 0.0037
4102 Proteasome subunit beta type 5 PSMB5 0.0037
4101 Proteasome subunit beta type 1 PSMB1 0.0037
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0036
3932 Glutathione S-transferase A2 GSTA2 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0035
54 Prothrombin F2 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0034
6755 Poliovirus receptor PVR 0.0034
165 FL cytokine receptor FLT3 0.0034
275 Arachidonate 5-lipoxygenase ALOX5 0.0034
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0034
88 Retinoic acid receptor RXR-beta RXRB 0.0034
6126 Carbonic anhydrase 7 CA7 0.0034
7 Nitric oxide synthase, inducible NOS2 0.0034
84 Nuclear receptor 0B1 NR0B1 0.0033
6506 Stathmin-4 STMN4 0.0033
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0033
173 Toll-like receptor 7 TLR7 0.0033
1630 Integrin beta-2 ITGB2 0.0033
823 Fibroblast growth factor receptor 2 FGFR2 0.0033
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
2499 Tubulin beta-2C chain TUBB2C 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
357 Carbonic anhydrase 2 CA2 0.0031
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0031
459 Retinoic acid receptor RXR-alpha RXRA 0.0031
1852 Microtubule-associated protein 2 MAP2 0.003
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
581 Cytochrome P450 2R1 CYP2R1 0.003
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
768 FK506-binding protein 1A FKBP1A 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0029
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
683 Potassium transporter GK0582 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0028
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
208 DNA-directed RNA polymerase beta' chain rpoC 0.0028
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
1992 Vitamin D-binding protein GC 0.0028
511 5-hydroxytryptamine 1F receptor HTR1F 0.0028
1200 AMBP protein AMBP 0.0028
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
2297 Genome polyprotein Not Available 0.0027
2322 Genome polyprotein Not Available 0.0027
2694 Genome polyprotein Not Available 0.0027
2719 Genome polyprotein Not Available 0.0027
2860 Genome polyprotein Not Available 0.0027
2928 Genome polyprotein Not Available 0.0027
3160 Genome polyprotein Not Available 0.0027
3260 Genome polyprotein Not Available 0.0027
4783 Genome polyprotein Not Available 0.0027
5726 Genome polyprotein Not Available 0.0027
5779 Genome polyprotein Not Available 0.0027
5867 Genome polyprotein Not Available 0.0027
6253 Genome polyprotein Not Available 0.0027
6301 Genome polyprotein Not Available 0.0027
6380 Genome polyprotein Not Available 0.0027
6381 Genome polyprotein Not Available 0.0027
6437 Genome polyprotein Not Available 0.0027
6520 Genome polyprotein Not Available 0.0027
6521 Genome polyprotein Not Available 0.0027
6652 Genome polyprotein Not Available 0.0027
6734 Genome polyprotein Not Available 0.0027
6735 Genome polyprotein Not Available 0.0027
6736 Genome polyprotein Not Available 0.0027
6737 Genome polyprotein Not Available 0.0027
6738 Genome polyprotein Not Available 0.0027
6739 Genome polyprotein Not Available 0.0027
6744 Genome polyprotein Not Available 0.0027
6748 Genome polyprotein Not Available 0.0027
6894 Genome polyprotein Not Available 0.0027
6898 Genome polyprotein Not Available 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
6146 High affinity copper uptake protein 1 SLC31A1 0.0027
4773 Deoxycytidine kinase DCK 0.0027
3809 Estrogen-related receptor gamma ESRRG 0.0026
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
6149 Solute carrier family 22 member 10 SLC22A10 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
4210 Toll-like receptor 4 TLR4 0.0026
992 Protein tyrosine kinase 2 beta PTK2B 0.0026
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
239 Coagulation factor X F10 0.0025
469 Annexin A1 ANXA1 0.0025
1541 Metalloproteinase mmp20 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
5787 Angiopoietin-1 receptor TEK 0.0024
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
3611 Cytidine deaminase cdd 0.0024
3707 Cytidine deaminase cdd 0.0024
4211 Cytidine deaminase CDA 0.0024
1050 Bile salt sulfotransferase SULT2A1 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0024
16 Adenosine A1 receptor ADORA1 0.0024
518 Peroxidase/catalase T katG 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
4122 Histone deacetylase 2 HDAC2 0.0023
233 Potassium channel subfamily K member 2 KCNK2 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0022
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
273 Apoptosis regulator Bcl-2 BCL2 0.0022
5934 Cytochrome P450 26A1 CYP26A1 0.0022
6020 Aldehyde oxidase AOX1 0.0022
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0022
291 Nitric-oxide synthase, endothelial NOS3 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0021
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
856 Vitamin D3 receptor VDR 0.0021
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0021
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0021
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0021
106 Cannabinoid receptor 2 CNR2 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6174 50S ribosomal protein L32 rpmF 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
144 Hemoglobin subunit alpha HBA1 0.002
5798 Mitogen-activated protein kinase 11 MAPK11 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
976 Platelet glycoprotein IX GP9 0.002
1502 Peroxisome proliferator-activated receptor delta PPARD 0.002
68 Cannabinoid receptor 1 CNR1 0.002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.002
172 Potassium channel subfamily K member 1 KCNK1 0.002
5961 Insulin INS 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
444 Alcohol dehydrogenase 1B ADH1B 0.0019
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0019
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
814 Ryanodine receptor 1 RYR1 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6316 ADP-ribosylation factor 1 ARF1 0.0019
6228 Nuclear receptor coactivator 1 NCOA1 0.0018
908 Glutathione S-transferase theta-1 GSTT1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0018
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0018
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0018
162 Retinoic acid receptor gamma-1 RARG 0.0018
1268 Neuropeptide S receptor NPSR1 0.0018
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0018
634 Squalene monooxygenase SQLE 0.0018
7196 Squalene monooxygenase ERG1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0018
251 Alcohol dehydrogenase 1A ADH1A 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
6524 Protein tonB tonB 0.0018
2207 Rhodopsin RHO 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
605 Fumarate reductase flavoprotein subunit frdA 0.0017
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0017
3673 Fumarate reductase flavoprotein subunit fccA 0.0017
4912 Fumarate reductase flavoprotein subunit ifcA 0.0017
6549 Fumarate reductase flavoprotein subunit frdA 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0017
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0017
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0017
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
3957 Adenosine deaminase ADA 0.0017
820 Glycine receptor subunit alpha-2 GLRA2 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
6073 Potassium channel subfamily K member 9 KCNK9 0.0017
6072 Potassium channel subfamily K member 3 KCNK3 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
5923 Microtubule-associated protein tau MAPT 0.0016
5924 Microtubule-associated protein 4 MAP4 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
6044 Serum paraoxonase/lactonase 3 PON3 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
3937 Fatty-acid amide hydrolase FAAH 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
2183 Fatty acid-binding protein, adipocyte FABP4 0.0016
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0016
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
1648 Elastin ELN 0.0015
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
6163 Copper-transporting ATPase 2 ATP7B 0.0015
6165 Copper-transporting ATPase 1 ATP7A 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
702 UMP-CMP kinase CMPK1 0.0015
572 Integrin alpha-L ITGAL 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0015
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0015
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
1864 RET proto-oncogene RET 0.0015
4311 tRNA TRDMT1 0.0014
4325 tRNA trmD 0.0014
4328 tRNA trmD 0.0014
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0014
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0014
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0014
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0014
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0014
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0014
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
6168 Solute carrier family 22 member 16 SLC22A16 0.0014
3086 Plasmepsin-2 Not Available 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0014
611 Retinal dehydrogenase 1 ALDH1A1 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
284 DNA-directed RNA polymerase beta chain rpoB 0.0014
5773 DNA-directed RNA polymerase beta chain rpoB 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
3404 Exotoxin A eta 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
4217 Telomerase reverse transcriptase TERT 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
3221 Cytochrome c4 cc4 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0012
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
76 Nitric-oxide synthase, brain NOS1 0.0011
473 L-lactate dehydrogenase A chain LDHA 0.0011
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
268 Adenosine A2b receptor ADORA2B 0.0011
6459 Glycodelin PAEP 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
2021 Thrombomodulin THBD 0.0011
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
1196 Complement decay-accelerating factor CD55 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
2320 Thymidine kinase, cytosolic TK1 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
4192 DNA topoisomerase 2-beta TOP2B 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
2808 Chloramphenicol acetyltransferase 3 cat3 0.0009
760 Fibroblast growth factor 1 FGF1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
6218 Pannexin-1 PANX1 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0009
33 Cystine/glutamate transporter SLC7A11 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
3808 Dihydropteroate synthase 2 folP2 0.0008
3601 Dihydropteroate synthase 1 folP1 0.0008
3807 Dihydropteroate synthase 1 folP1 0.0008
2417 Chloramphenicol acetyltransferase cat 0.0008
3278 Chloramphenicol acetyltransferase cat 0.0008
2810 Dr hemagglutinin structural subunit draA 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0007
6043 Putative G-protein coupled receptor 44 GPR44 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
3917 Methylenetetrahydrofolate reductase MTHFR 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4984 Neuroglobin NGB 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
4943 Cytochrome c6 petJ 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4910 Cytoglobin CYGB 0.0005
5000 HemO hemO 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4909 CooA protein cooA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4961 Hemophore HasA hasA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4972 P450cin cinA 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3093 Catalase HPII katE 0.0005
4952 Catalase/peroxidase katA 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
358 Cystathionine beta-synthase CBS 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2298 Cytochrome P450-cam camC 0.0002
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