DT-Web

DB00208 - Ticlopidine


Identification
Name Ticlopidine
Accession Number DB00208 (APRD01257)
Type small molecule
Description Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 263.786
Groups approved
Monoisotopic Weight 263.05354785
Pharmacology
Indication Used in patients, who have had a stroke or stroke precursors and who cannot take aspirin or aspirin has not worked, to try to prevent another thrombotic stroke.
Mechanism of action The active metabolite of ticlopidine prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. No direct interference occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of ticlopidine.
Absorption Absorption is greater than 80%. Food increases absorption by approximately 20%.
Protein binding Binds reversibly (98%) to plasma proteins, mainly to serum albumin and lipoproteins. The binding to albumin and lipoproteins is nonsaturable over a wide concentration range. Ticlopidine also binds to alpha-1 acid glycoprotein (about 15% or less).
Biotransformation Ticlopidine is metabolized extensively by the liver with only trace amounts of intact drug detected. At least 20 metabolites have been identified.
Route of elimination Ticlopidine is eliminated mostly in the urine (60%) and somewhat in the feces (23%).
Toxicity Single oral doses of ticlopidine at 1600 mg/kg and 500 mg/kg were lethal to rats and mice, respectively. Symptoms of acute toxicity were GI hemorrhage, convulsions, hypothermia, dyspnea, loss of equilibrium and abnormal gait. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetylsalicylic acid Increased effect of ticlopidine
Alteplase Increased bleeding risk. Monitor for signs of bleeding.
ambrisentan Ticlopidine may decrease the metabolism and clearance of Ambrisentan. Consider alternate therapy or monitor for adverse/toxic effects of Ambrisentan if Ticlopidine is initiated, discontinued or dose changed.
Aminophylline Ticlopidine increases the effect and toxicity of theophylline
Bortezomib Ticlopidine may decrease the metabolism and clearance of Bortezomib. Consider alternate therapy or monitor for adverse/toxic effects of Bortezomib if Ticlopidine is initiated, discontinued or dose changed.
Carbamazepine Ticlopidine increases the effect of carbamazepine
Carisoprodol Ticlopidine may decrease the metabolism and clearance of Carisoprodol. Consider alternate therapy or monitor for adverse/toxic effects of Carisoprodol if Ticlopidine is initiated, discontinued or dose changed.
Cilostazol Ticlopidine may decrease the metabolism and clearance of Cilostazol. Consider alternate therapy or monitor for adverse/toxic effects of Cilostazol if Ticlopidine is initiated, discontinued or dose changed.
Cimetidine Cimetidine may increase Ticlopidine levels. Avoid concomitant therapy.
Citalopram Ticlopidine may decrease the metabolism and clearance of Citalopram. Consider alternate therapy or monitor for adverse/toxic effects of Citalopram if Ticlopidine is initiated, discontinued or dose changed.
Clobazam Ticlopidine may decrease the metabolism and clearance of Clobazam. Consider alternate therapy or monitor for adverse/toxic effects of Clobazam if Ticlopidine is initiated, discontinued or dose changed.
Clomipramine Ticlopidine may decrease the metabolism and clearance of Clomipramine. Consider alternate therapy or monitor for adverse/toxic effects of Clomipramine if Ticlopidine is initiated, discontinued or dose changed.
Cyclosporine Ticlopidine decreases the effect of cyclosporine
Diazepam Ticlopidine may decrease the metabolism and clearance of Diazepam. Consider alternate therapy or monitor for adverse/toxic effects of Diazepam if Ticlopidine is initiated, discontinued or dose changed.
Digoxin Ticlopidine may decrease Digoxin levels. Monitor for Digoxin levels with Ticlopidine is initiated, discontinued or dose changed.
Dyphylline Ticlopidine increases the effect and toxicity of theophylline
Escitalopram Ticlopidine may decrease the metabolism and clearance of Escitalopram. Consider alternate therapy or monitor for adverse/toxic effects of Ambrisentan if Escitalopram is initiated, discontinued or dose changed.
Ethotoin Ticlopidine increases the effect of hydantoin
Fosphenytoin Ticlopidine may decrease the metabolism and clearance of Fosphenytoin. Consider alternate therapy or monitor for adverse/toxic effects of Fosphenytoin if Ticlopidine is initiated, discontinued or dose changed.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Heparin Increased bleeding risk. Monitor aPTT.
Ifosfamide Ticlopidine may decrease the metabolism and clearance of Ifosfamide. Consider alternate therapy or monitor for adverse/toxic effects of Ifosfamide if Ticlopidine is initiated, discontinued or dose changed.
Imipramine Ticlopidine may decrease the metabolism and clearance of Imipramine. Consider alternate therapy or monitor for adverse/toxic effects of Imipramine if Ticlopidine is initiated, discontinued or dose changed.
Mephenytoin Ticlopidine increases the effect of hydantoin
Methsuximide Ticlopidine may decrease the metabolism and clearance of Methsuximide. Consider alternate therapy or monitor for adverse/toxic effects of Methsuximide if Ticlopidine is initiated, discontinued or dose changed.
Moclobemide Ticlopidine may decrease the metabolism and clearance of Moclobemide. Consider alternate therapy or monitor for adverse/toxic effects of Moclobemide if Ticlopidine is initiated, discontinued or dose changed.
Nilutamide Ticlopidine may decrease the metabolism and clearance of Nilutamide. Consider alternate therapy or monitor for adverse/toxic effects of Nilutamide if Ticlopidine is initiated, discontinued or dose changed.
Oxtriphylline Ticlopidine increases the effect and toxicity of theophylline
Pentamidine Ticlopidine may decrease the metabolism and clearance of Pentamidine. Consider alternate therapy or monitor for adverse/toxic effects of Pentamidine if Ticlopidine is initiated, discontinued or dose changed.
Phenobarbital Ticlopidine may decrease the metabolism and clearance of Phenobarbital. Consider alternate therapy or monitor for adverse/toxic effects of Phenobarbital if Ticlopidine is initiated, discontinued or dose changed.
Phenytoin Ticlopidine may decrease the metabolism and clearance of phenytoin. Consider alternate therapy or monitor for adverse/toxic effects of phenytoin if ticlopidine is initiated, discontinued or dose changed.
Pimozide Avoid combination with pimozide and other major CYP3A4 substrates due to the potential increase of pimozide concentration.
Reteplase Increased bleeding risk. Monitor for signs of bleeding.
Sodium bicarbonate Sodium bicarbonate may decrease Ticlopidine levels. Administer agents 1 to 2 hours apart.
Streptokinase Increased bleeding risk. Monitor for signs of bleeding.
Tamoxifen Ticlopidine may decrease the therapeutic effect of tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Ticlopidine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Ticlopidine is initiated, discontinued, or dose changed.
Tenecteplase Increased bleeding risk. Monitor for signs of bleeding.
Theophylline Ticlopidine increases the effect and toxicity of theophylline
Thioridazine Ticlopidine may decrease the metabolism of thioridazine. Concomitant therapy is contraindicated.
Tizanidine Ticlopidine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Tramadol Ticlopidine may decrease the effect of Tramadol by decreasing active metabolite production.
Treprostinil The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Ticlopidine. Monitor for increased bleeding during concomitant thearpy.
Trimipramine The strong CYP2C19 inhibitor, ticlopidine, may decrease the metabolism and clearance of trimipramine, a CYP2C19 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of trimipramine if ticlopidine is initiated, discontinued or dose changed.
Warfarin Increased bleeding risk. Monitor INR.
Food Interactions
  • High fat meals will increase ticlopidine absorption. As well, food can help ticlopidine-induced stomach upset.

Targets


P2Y purinoceptor 12
Name P2Y purinoceptor 12
Gene Name P2RY12
Pharmacological action yes
Actions antagonist
References
  • Storey RF: The P2Y12 receptor as a therapeutic target in cardiovascular disease. Platelets. 2001 Jun;12(4):197-209. - Pubmed
  • Boeynaems JM, van Giezen H, Savi P, Herbert JM: P2Y receptor antagonists in thrombosis. Curr Opin Investig Drugs. 2005 Mar;6(3):275-82. - Pubmed
  • Gachet C: The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacol Ther. 2005 Nov;108(2):180-92. Epub 2005 Jun 13. - Pubmed
  • Zhan C, Yang J, Dong XC, Wang YL: Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists. J Mol Graph Model. 2007 Jul;26(1):20-31. Epub 2006 Sep 26. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3475

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5626
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6002
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8232
Myeloperoxidase
Name Myeloperoxidase
Gene Name MPO
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3346
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6934
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4481
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5994
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3291
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.43
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3928

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.3371
4118 Cytochrome P450 3A5 CYP3A5 0.2715
6107 Cytochrome P450 3A7 CYP3A7 0.1879
5718 Cytochrome P450 2A6 CYP2A6 0.1759
20 Prostaglandin G/H synthase 1 PTGS1 0.1534
587 Serum albumin ALB 0.1346
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1143
527 Prostacyclin receptor PTGIR 0.1081
290 Prostaglandin G/H synthase 2 PTGS2 0.1051
492 Histamine H1 receptor HRH1 0.0946
6106 Cytochrome P450 2C18 CYP2C18 0.0911
824 Sodium-dependent serotonin transporter SLC6A4 0.0797
1898 Cytochrome P450 1B1 CYP1B1 0.0794
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0772
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0767
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0757
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0747
3811 Cytochrome P450 19A1 CYP19A1 0.0689
1729 Solute carrier family 22 member 6 SLC22A6 0.0678
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0632
502 5-hydroxytryptamine 2A receptor HTR2A 0.0624
130 Prostacyclin synthase PTGIS 0.0603
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.06
831 D(2) dopamine receptor DRD2 0.0597
556 Alpha-1A adrenergic receptor ADRA1A 0.0579
862 Multidrug resistance-associated protein 1 ABCC1 0.0575
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0571
6145 Solute carrier family 22 member 1 SLC22A1 0.0561
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0553
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0546
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0544
713 Sodium-dependent dopamine transporter SLC6A3 0.0529
6144 Solute carrier family 22 member 2 SLC22A2 0.0528
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.051
118 Organic cation/carnitine transporter 2 SLC22A5 0.0497
3941 Amine oxidase [flavin-containing] A MAOA 0.0487
136 Estrogen receptor ESR1 0.0487
318 Alpha-2A adrenergic receptor ADRA2A 0.0479
766 Beta-2 adrenergic receptor ADRB2 0.0451
468 Cytochrome P450 4A11 CYP4A11 0.0446
776 Bile salt export pump ABCB11 0.0433
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0431
590 5-hydroxytryptamine 2C receptor HTR2C 0.0425
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0424
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0422
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0413
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0411
193 Beta-1 adrenergic receptor ADRB1 0.0401
23 D(1A) dopamine receptor DRD1 0.0399
341 5-hydroxytryptamine 3 receptor HTR3A 0.0396
260 Cytochrome P450 51 ERG11 0.0394
761 Cytochrome P450 51 ERG11 0.0394
3163 Cytochrome P450 51 cyp51 0.0394
6142 Solute carrier family 22 member 8 SLC22A8 0.0392
465 Calmodulin CALM1 0.0392
3939 Amine oxidase [flavin-containing] B MAOB 0.038
320 5-hydroxytryptamine 1A receptor HTR1A 0.0369
731 HIV-1 protease HIV-1 protease 0.0365
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0361
632 Alpha-1B adrenergic receptor ADRA1B 0.0361
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.036
847 Mu-type opioid receptor OPRM1 0.0358
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0355
4604 Liver carboxylesterase 1 CES1 0.0352
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0341
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0337
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0336
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0336
2164 Multidrug resistance-associated protein 4 ABCC4 0.0335
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0332
6147 Solute carrier family 22 member 3 SLC22A3 0.0327
871 Glucocorticoid receptor NR3C1 0.0327
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0326
563 Thyroid peroxidase TPO 0.0325
1736 Somatostatin SST 0.0311
275 Arachidonate 5-lipoxygenase ALOX5 0.0311
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0311
4186 Neuropeptide Y receptor type 2 NPY2R 0.0311
153 Dopamine beta-hydroxylase DBH 0.0311
833 Organic cation/carnitine transporter 1 SLC22A4 0.0308
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0303
467 Delta-type opioid receptor OPRD1 0.0301
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0298
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0295
6020 Aldehyde oxidase AOX1 0.0294
696 Kappa-type opioid receptor OPRK1 0.0293
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0291
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0287
885 5-hydroxytryptamine 1B receptor HTR1B 0.0279
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0279
817 DNA topoisomerase 2-alpha TOP2A 0.0277
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0276
6031 Cytochrome P450 3A43 CYP3A43 0.0276
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0274
856 Vitamin D3 receptor VDR 0.0273
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0269
6143 Solute carrier family 22 member 7 SLC22A7 0.0269
638 D(3) dopamine receptor DRD3 0.0267
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0264
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0261
36 Insulin receptor INSR 0.0258
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0258
54 Prothrombin F2 0.0258
723 Cytosolic phospholipase A2 PLA2G4A 0.0256
777 Tumor necrosis factor TNF 0.0254
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0253
309 Antithrombin-III SERPINC1 0.0251
789 Alpha-1D adrenergic receptor ADRA1D 0.0247
3947 Xanthine dehydrogenase/oxidase XDH 0.0246
891 Dihydropteroate synthase folP 0.0238
5359 Dihydropteroate synthase folP 0.0238
7175 Dihydropteroate synthase sulI 0.0238
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0238
3923 Cholinesterase BCHE 0.0237
3866 Serum amyloid A protein SAA1 0.0236
1932 Apolipoprotein E APOE 0.0236
1200 AMBP protein AMBP 0.0236
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0234
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0232
146 Androgen receptor AR 0.023
6014 Cytochrome P450 2A13 CYP2A13 0.023
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0228
239 Coagulation factor X F10 0.0225
6102 Arylamine N-acetyltransferase 2 NAT2 0.0225
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0225
629 Alpha-2B adrenergic receptor ADRA2B 0.022
725 5-hydroxytryptamine 1D receptor HTR1D 0.0219
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0219
6146 High affinity copper uptake protein 1 SLC31A1 0.0218
6220 Aryl hydrocarbon receptor AHR 0.0215
503 Somatostatin receptor type 1 SSTR1 0.0214
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0214
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0213
6182 Cytochrome P450 2J2 CYP2J2 0.0208
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0206
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0205
16 Adenosine A1 receptor ADORA1 0.0204
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0203
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0203
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
3872 Somatostatin receptor type 5 SSTR5 0.02
6008 Somatostatin receptor type 2 SSTR2 0.02
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
378 Alpha-2C adrenergic receptor ADRA2C 0.0194
482 Glycine receptor subunit alpha-1 GLRA1 0.019
1010 Cytochrome P450 51A1 CYP51A1 0.0189
6136 Multidrug resistance-associated protein 5 ABCC5 0.0189
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0185
1024 Solute carrier family 22 member 11 SLC22A11 0.0184
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0184
432 D(4) dopamine receptor DRD4 0.0181
571 Melatonin receptor type 1A MTNR1A 0.0181
362 Melatonin receptor type 1B MTNR1B 0.0181
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0179
613 Atrial natriuretic peptide receptor A NPR1 0.0179
908 Glutathione S-transferase theta-1 GSTT1 0.0178
1178 Adenosine A2a receptor ADORA2A 0.0177
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0175
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0173
904 Glutathione S-transferase P GSTP1 0.0173
811 Translocator protein TSPO 0.0172
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0172
6165 Copper-transporting ATPase 1 ATP7A 0.0171
6163 Copper-transporting ATPase 2 ATP7B 0.0171
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0171
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0171
6137 Multidrug resistance-associated protein 6 ABCC6 0.0171
70 Type-1 angiotensin II receptor AGTR1 0.017
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0168
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0168
633 Penicillin-binding proteins 1A/1B pbpA 0.0167
504 Mast/stem cell growth factor receptor KIT 0.0167
844 Epidermal growth factor receptor EGFR 0.0166
6148 Multidrug resistance-associated protein 7 ABCC10 0.0164
94 5-hydroxytryptamine 4 receptor HTR4 0.0163
477 DNA topoisomerase 4 subunit A parC 0.0162
886 DNA topoisomerase 4 subunit A parC 0.0162
6226 DNA topoisomerase 4 subunit A parC 0.0162
436 5-hydroxytryptamine 2B receptor HTR2B 0.0162
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.016
115 Penicillin-binding protein 2 mrdA 0.016
6069 Penicillin-binding protein 2 mrdA 0.016
6118 Penicillin-binding protein 2 penA 0.016
6187 Penicillin-binding protein 2 pbpA 0.016
6686 Penicillin-binding protein 2 pbp2 0.016
6939 Penicillin-binding protein 2 mrdA 0.016
7163 Penicillin-binding protein 2 pbpA 0.016
867 Penicillin-binding protein 3 pbpC 0.016
6119 Penicillin-binding protein 3 pbp3 0.016
7154 Penicillin-binding protein 3 pbp3 0.016
7157 Penicillin-binding protein 3 LMHCC_2184 0.016
7162 Penicillin-binding protein 3 pbpB 0.016
7172 Penicillin-binding protein 3 pbp3 0.016
404 DNA gyrase subunit A gyrA 0.016
6224 DNA gyrase subunit A gyrA 0.016
380 Cytochrome P450 17A1 CYP17A1 0.0158
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0158
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0157
6012 Tryptophan 2,3-dioxygenase TDO2 0.0155
4120 NADPH--cytochrome P450 reductase POR 0.0154
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0153
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0153
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0151
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.015
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.015
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.015
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0147
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0147
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0147
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0147
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0146
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0146
869 Estrogen receptor beta ESR2 0.0146
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0145
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0145
896 Glutathione S-transferase Mu 1 GSTM1 0.0145
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0144
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0143
124 Histamine H2 receptor HRH2 0.0142
6141 Sodium/bile acid cotransporter SLC10A1 0.0141
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0141
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0139
705 Glutamate receptor 1 GRIA1 0.0138
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0136
537 ATP synthase delta chain, mitochondrial ATP5D 0.0136
373 Transthyretin TTR 0.0136
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0135
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0135
716 5-hydroxytryptamine 7 receptor HTR7 0.0134
818 50S ribosomal protein L10 rplJ 0.0134
295 Carbonic anhydrase 1 CA1 0.0132
614 Progesterone receptor PGR 0.0131
365 Dihydrofolate reductase DHFR 0.0131
2381 Dihydrofolate reductase DFR1 0.0131
2833 Dihydrofolate reductase Not Available 0.0131
2931 Dihydrofolate reductase folA 0.0131
3544 Dihydrofolate reductase folA 0.0131
3682 Dihydrofolate reductase folA 0.0131
6642 Dihydrofolate reductase folA 0.0131
6756 Dihydrofolate reductase dfrA 0.0131
4116 Dihydropteroate synthetase Not Available 0.0131
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.013
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.013
4122 Histone deacetylase 2 HDAC2 0.0129
790 DNA polymerase subunit alpha B POLA2 0.0129
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0127
174 Sigma 1-type opioid receptor SIGMAR1 0.0127
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0127
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0127
3932 Glutathione S-transferase A2 GSTA2 0.0126
756 Sex hormone-binding globulin SHBG 0.0126
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0126
1656 CYP2B protein CYP2B 0.0125
161 Tubulin beta chain TUBB 0.0125
312 Tubulin beta chain TUB2 0.0125
592 Carbonic anhydrase 4 CA4 0.0125
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0124
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0124
921 Glutamate receptor 2 GRIA2 0.0123
407 Vascular endothelial growth factor receptor 2 KDR 0.0122
1517 Beta-3 adrenergic receptor ADRB3 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.012
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0118
163 D(1B) dopamine receptor DRD5 0.0118
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0116
48 Pyridoxal kinase PDXK 0.0116
3601 Dihydropteroate synthase 1 folP1 0.0116
3807 Dihydropteroate synthase 1 folP1 0.0116
3808 Dihydropteroate synthase 2 folP2 0.0116
228 Beta platelet-derived growth factor receptor PDGFRB 0.0115
26 Vascular endothelial growth factor receptor 3 FLT4 0.0114
474 Acetylcholinesterase ACHE 0.0113
2449 Tubulin alpha-3 chain TUBA1A 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0113
2499 Tubulin beta-2C chain TUBB2C 0.0113
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0112
427 Substance-P receptor TACR1 0.0111
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.011
29 Tubulin beta-1 chain TUBB1 0.011
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.011
32 Vascular endothelial growth factor receptor 1 FLT1 0.0109
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0106
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0106
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0106
4203 Histamine N-methyltransferase HNMT 0.0104
823 Fibroblast growth factor receptor 2 FGFR2 0.0104
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0102
3810 Catechol O-methyltransferase COMT 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
3830 Calreticulin CALR 0.0101
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.01
6036 Eosinophil peroxidase EPX 0.0099
2112 Toll-like receptor 9 TLR9 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
952 Dipeptidyl peptidase 4 DPP4 0.0096
1192 Sulfotransferase 1A1 SULT1A1 0.0096
49 Endothelin B receptor EDNRB 0.0096
6034 Hydroxyindole O-methyltransferase ASMT 0.0096
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0095
6035 Nuclear receptor ROR-beta RORB 0.0095
1256 5-hydroxytryptamine 6 receptor HTR6 0.0094
6126 Carbonic anhydrase 7 CA7 0.0094
820 Glycine receptor subunit alpha-2 GLRA2 0.0094
4311 tRNA TRDMT1 0.0093
4325 tRNA trmD 0.0093
4328 tRNA trmD 0.0093
357 Carbonic anhydrase 2 CA2 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
251 Alcohol dehydrogenase 1A ADH1A 0.0092
518 Peroxidase/catalase T katG 0.0091
6085 Fatty acid-binding protein, intestinal FABP2 0.0091
578 Endothelin-1 receptor EDNRA 0.009
183 Vascular endothelial growth factor A VEGFA 0.009
814 Ryanodine receptor 1 RYR1 0.009
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
6766 O-GlcNAcase BT_4395 BT_4395 0.0089
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
444 Alcohol dehydrogenase 1B ADH1B 0.0088
1629 Transcription factor AP-1 JUN 0.0087
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0087
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0086
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0085
581 Cytochrome P450 2R1 CYP2R1 0.0085
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0084
1050 Bile salt sulfotransferase SULT2A1 0.0083
68 Cannabinoid receptor 1 CNR1 0.0083
765 Indoleamine 2,3-dioxygenase IDO1 0.0083
88 Retinoic acid receptor RXR-beta RXRB 0.0082
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0082
84 Nuclear receptor 0B1 NR0B1 0.0082
131 Synaptic vesicular amine transporter SLC18A2 0.008
565 Extracellular calcium-sensing receptor CASR 0.008
634 Squalene monooxygenase SQLE 0.0079
7196 Squalene monooxygenase ERG1 0.0079
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0079
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
528 5-hydroxytryptamine 1E receptor HTR1E 0.0078
6138 Multidrug resistance protein 3 ABCB4 0.0077
737 Mineralocorticoid receptor NR3C2 0.0077
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0076
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0076
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0076
1275 Estrogen sulfotransferase SULT1E1 0.0076
1618 High affinity nerve growth factor receptor NTRK1 0.0075
6432 Transporter snf 0.0075
1541 Metalloproteinase mmp20 0.0074
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0074
284 DNA-directed RNA polymerase beta chain rpoB 0.0074
5773 DNA-directed RNA polymerase beta chain rpoB 0.0074
976 Platelet glycoprotein IX GP9 0.0073
6043 Putative G-protein coupled receptor 44 GPR44 0.0073
33 Cystine/glutamate transporter SLC7A11 0.0073
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
6168 Solute carrier family 22 member 16 SLC22A16 0.0071
517 Alcohol dehydrogenase 1C ADH1C 0.007
1992 Vitamin D-binding protein GC 0.007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0069
738 Monocarboxylate transporter 1 SLC16A1 0.0069
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0069
3937 Fatty-acid amide hydrolase FAAH 0.0069
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0069
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0069
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0069
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0068
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0067
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0067
780 Retinoic acid receptor RXR-gamma RXRG 0.0067
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0067
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0065
273 Apoptosis regulator Bcl-2 BCL2 0.0065
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0065
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0065
319 Opioid receptor, sigma 1 OPRS1 0.0065
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0065
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0064
3809 Estrogen-related receptor gamma ESRRG 0.0064
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0064
1820 Beta-nerve growth factor NGF 0.0064
1648 Elastin ELN 0.0063
133 Dihydropterate synthase sulI 0.0063
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0061
511 5-hydroxytryptamine 1F receptor HTR1F 0.0061
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.006
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.006
24 Thymidylate synthase TMP1 0.0059
359 Thymidylate synthase TYMS 0.0059
2626 Thymidylate synthase thyA 0.0059
2729 Thymidylate synthase thyA 0.0059
5352 Thymidylate synthase THYA 0.0059
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0059
4103 Proteasome subunit beta type 2 PSMB2 0.0059
4102 Proteasome subunit beta type 5 PSMB5 0.0059
4101 Proteasome subunit beta type 1 PSMB1 0.0059
5934 Cytochrome P450 26A1 CYP26A1 0.0059
7 Nitric oxide synthase, inducible NOS2 0.0059
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0058
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
5880 Thrombopoietin receptor MPL 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0058
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0058
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0058
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
469 Annexin A1 ANXA1 0.0057
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0057
162 Retinoic acid receptor gamma-1 RARG 0.0057
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
6044 Serum paraoxonase/lactonase 3 PON3 0.0057
106 Cannabinoid receptor 2 CNR2 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
551 Carnitine O-acetyltransferase CRAT 0.0057
1714 Mitogen-activated protein kinase 3 MAPK3 0.0056
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0056
6506 Stathmin-4 STMN4 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
1374 Natriuretic peptides B NPPB 0.0054
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0054
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0054
1827 Gap junction alpha-1 protein GJA1 0.0054
1908 Vascular cell adhesion protein 1 VCAM1 0.0054
3957 Adenosine deaminase ADA 0.0054
268 Adenosine A2b receptor ADORA2B 0.0054
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0053
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
712 Tubulin alpha chain TUB1 0.0052
3426 Glutamine synthetase glnA 0.0052
3987 Glutamine synthetase GLUL 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
751 Potassium channel subfamily K member 6 KCNK6 0.0051
164 Histamine H4 receptor HRH4 0.005
165 FL cytokine receptor FLT3 0.005
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.005
2981 Phospholipase A2, membrane associated PLA2G2A 0.005
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0049
569 Retinal dehydrogenase 2 ALDH1A2 0.0049
3404 Exotoxin A eta 0.0049
3917 Methylenetetrahydrofolate reductase MTHFR 0.0049
1630 Integrin beta-2 ITGB2 0.0048
2230 Catalase CAT 0.0048
3249 Catalase katA 0.0048
3625 Catalase katA 0.0048
4539 Catalase katA 0.0048
4941 Catalase katB 0.0048
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0048
936 Ephrin type-A receptor 2 EPHA2 0.0048
172 Potassium channel subfamily K member 1 KCNK1 0.0046
1253 Interferon gamma IFNG 0.0046
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0046
2236 Casein kinase II subunit alpha CSNK2A1 0.0046
611 Retinal dehydrogenase 1 ALDH1A1 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
3086 Plasmepsin-2 Not Available 0.0045
3856 Fibroblast growth factor receptor 3 FGFR3 0.0045
6174 50S ribosomal protein L32 rpmF 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
4192 DNA topoisomerase 2-beta TOP2B 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
65 Matrix metalloproteinase-9 Not Available 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
5787 Angiopoietin-1 receptor TEK 0.0044
267 Plasminogen activator inhibitor 1 SERPINE1 0.0044
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0044
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0043
719 Retinoic acid receptor responder protein 1 RARRES1 0.0043
770 Retinoic acid-induced protein 3 GPRC5A 0.0043
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0042
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0041
1176 Mitogen-activated protein kinase 1 MAPK1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0041
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0041
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0041
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0041
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0041
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
3913 Glutamic acid decarboxylase GAD65 0.004
6221 Steroid hormone receptor ERR1 ESRRA 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0038
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0038
85 Growth hormone receptor GHR 0.0038
400 Coagulation factor IX F9 0.0037
5461 Coagulation factor IX F9 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0037
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0037
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0036
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0036
6131 Carbonic anhydrase 14 CA14 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0034
604 Vitamin K-dependent protein Z PROZ 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0034
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
735 Alanine aminotransferase 1 GPT 0.0033
3904 Alanine aminotransferase 2 GPT2 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
229 Retinoic acid receptor beta RARB 0.0033
1360 Sphingomyelin phosphodiesterase SMPD1 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
1039 Histone deacetylase 9 HDAC9 0.0032
5798 Mitogen-activated protein kinase 11 MAPK11 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
422 Vitamin K-dependent protein C PROC 0.0031
1245 Vitamin K-dependent protein S PROS1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
291 Nitric-oxide synthase, endothelial NOS3 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6149 Solute carrier family 22 member 10 SLC22A10 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.003
1268 Neuropeptide S receptor NPSR1 0.003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.003
2298 Cytochrome P450-cam camC 0.003
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
1569 G1/S-specific cyclin-D1 CCND1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0028
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0028
2207 Rhodopsin RHO 0.0028
4217 Telomerase reverse transcriptase TERT 0.0028
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0028
1063 Signal transducer and activator of transcription 5B STAT5B 0.0028
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
6073 Potassium channel subfamily K member 9 KCNK9 0.0027
6072 Potassium channel subfamily K member 3 KCNK3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
572 Integrin alpha-L ITGAL 0.0027
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0027
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0027
358 Cystathionine beta-synthase CBS 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
798 Osteocalcin BGLAP 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
3007 Carbonic anhydrase 12 CA12 0.0025
4205 Carbonic anhydrase 9 CA9 0.0025
1864 RET proto-oncogene RET 0.0025
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4226 Uridine phosphorylase 2 UPP2 0.0023
6048 Troponin C, skeletal muscle TNNC2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
1341 Histamine H3 receptor HRH3 0.0023
369 Coagulation factor VII F7 0.0023
822 Aldose reductase AKR1B1 0.0023
484 Tyrosine-protein kinase ABL2 ABL2 0.0022
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0021
997 Protein kinase C beta type PRKCB 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0021
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
2021 Thrombomodulin THBD 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
1970 Protein kinase C alpha type PRKCA 0.002
6218 Pannexin-1 PANX1 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
2216 Fibroblast growth factor receptor 4 FGFR4 0.0019
2408 Tyrosine-protein kinase SYK SYK 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
3221 Cytochrome c4 cc4 0.0018
489 Monocarboxylate transporter 2 SLC16A7 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6459 Glycodelin PAEP 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
1243 Cathepsin D CTSD 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6859 Protein S100-A4 S100A4 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
244 Angiotensin-converting enzyme ACE 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
76 Nitric-oxide synthase, brain NOS1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6677 Myelin P2 protein PMP2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
2802 Endoglucanase G celCCG 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
693 Hemoglobin subunit beta HBB 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
2240 Cell division protein kinase 2 CDK2 0.0003
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