DT-Web

DB00188 - Bortezomib


Identification
Name Bortezomib
Accession Number DB00188 (APRD00828)
Type small molecule
Description Bortezomib (originally PS-341 and marketed as Velcade by Millennium Pharmaceuticals) is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 384.237
Groups approved
Monoisotopic Weight 384.196885774
Pharmacology
Indication For treatment of multiple myeloma in patients who have not been successfully treated with at least two previous therapies.
Mechanism of action Bortezomib is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The active site of the proteasome has chymotrypsin-like, trypsin-like, and postglutamyl peptide hydrolysis activity. The 26S proteasome degrades various proteins critical to cancer cell survival, such as cyclins, tumor suppressors, BCL-2, and cyclin-dependent kinase inhibitors. Inhibition of these degradations sensitizes cells to apoptosis. Bortezomib is a potent inhibitor of 26S proteasome, which sensitizes activity in dividing multiple myeloma and leukemic cells, thus inducing apoptosis. In addition, bortezomib appears to increase the sensitivity of cancer cells to traditional anticancer agents (e.g., gemcitabine, cisplatin, paclitaxel, irinotecan, and radiation).
Absorption Not Available
Protein binding 83% over the concentration range of 100-1000 ng/ml.
Biotransformation In vitro studies with human liver microsomes and human cDNA-expressed cytochrome P450 isozymes indicate that bortezomib is primarily oxidatively metabolized via cytochrome P450 enzymes 3A4, 2C19, and 1A2, while bortezomib metabolism by CYP 2D6 and 2C9 enzymes is minor. The major metabolic pathway is deboronation to form 2 deboronated metabolites that subsequently undergo hydroxylation to several metabolites which are inactive as 26S proteasome inhibitors.
Route of elimination The pathways of elimination of bortezomib have not been characterized in humans.
Toxicity Cardiovascular safety pharmacology studies in monkeys show that lethal IV doses are associated with decreases in blood pressure, increases in heart rate, increases in contractility, and ultimately terminal hypotension. In monkeys, doses of 3.0 mg/m2 and greater (approximately twice the recommended clinical dose) resulted in progressive hypotension starting at 1 hour and progressing to death by 12 to 14 hours following drug administration.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Clopidogrel Moderate CYP2C19 Inhibitors like bortezomib may decrease serum concentrations of the active metabolite(s) of Clopidogrel. Avoid concurrent use of moderate CYP2C19 inhibitors with clopidogrel whenever possible. If such a combination must be used, monitor closely for evidence of reduced clinical response to clopidogrel.
Etravirine Bortezombib, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to avoid this combination.
Telithromycin Telithromycin may reduce clearance of Bortezomib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Bortezomib if Telithromycin is initiated, discontinued or dose changed.
Ticlopidine Ticlopidine may decrease the metabolism and clearance of Bortezomib. Consider alternate therapy or monitor for adverse/toxic effects of Bortezomib if Ticlopidine is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of bortezomib by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bortezomib if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Citrus fruits - Patients should avoid taking extra vitamin C (ascorbic acid) supplements and vitamin C-containing multi-vitamins during their bortezomib therapy. Ascorbic Acid may diminish the therapeutic effect of Bortezomib.
  • Green Tea - Green Tea may diminish the antineoplastic effect of Bortezomib. Avoid concurrent use of green tea extract and other green tea products during treatment with bortezomib.

Targets


26S proteasome non-ATPase regulatory subunit 2
Name 26S proteasome non-ATPase regulatory subunit 2
Gene Name PSMD2
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • von Schwarzenberg K, Held SA, Schaub A, Brauer KM, Bringmann A, Brossart P: Proteasome inhibition overcomes the resistance of renal cell carcinoma cells against the PPARgamma ligand troglitazone. Cell Mol Life Sci. 2009 Apr;66(7):1295-308. - Pubmed
  • Marchi E, Paoluzzi L, Scotto L, Seshan VE, Zain JM, Zinzani PL, O'Connor OA: Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies. Clin Cancer Res. 2010 Jul 15;16(14):3648-58. Epub 2010 May 25. - Pubmed
  • Saeki Y, Fukunaga K, Tanaka K: [Proteasome inhibitors]. Nippon Rinsho. 2010 Oct;68(10):1818-22. - Pubmed
DTHybrid score 0.4009
Proteasome subunit beta type 1
Name Proteasome subunit beta type 1
Gene Name PSMB1
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Saeki Y, Fukunaga K, Tanaka K: [Proteasome inhibitors]. Nippon Rinsho. 2010 Oct;68(10):1818-22. - Pubmed
DTHybrid score 0.755
Proteasome subunit beta type 5
Name Proteasome subunit beta type 5
Gene Name PSMB5
Pharmacological action yes
Actions antagonist
References
  • Politou M, Karadimitris A, Terpos E, Kotsianidis I, Apperley JF, Rahemtulla A: No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib. Leuk Res. 2006 Feb;30(2):240-1. Epub 2005 Aug 2. - Pubmed
  • Saeki Y, Fukunaga K, Tanaka K: [Proteasome inhibitors]. Nippon Rinsho. 2010 Oct;68(10):1818-22. - Pubmed
DTHybrid score 0.755
Proteasome subunit beta type 2
Name Proteasome subunit beta type 2
Gene Name PSMB2
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Saeki Y, Fukunaga K, Tanaka K: [Proteasome inhibitors]. Nippon Rinsho. 2010 Oct;68(10):1818-22. - Pubmed
DTHybrid score 0.7552
26S proteasome non-ATPase regulatory subunit 1
Name 26S proteasome non-ATPase regulatory subunit 1
Gene Name PSMD1
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Saeki Y, Fukunaga K, Tanaka K: [Proteasome inhibitors]. Nippon Rinsho. 2010 Oct;68(10):1818-22. - Pubmed
DTHybrid score 0.4009

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.742
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5519
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6023
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.598
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6646
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5926
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3921
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4815

Transporters


High affinity copper uptake protein 1
Name High affinity copper uptake protein 1
Gene Name SLC31A1
Actions inhibitor
References
  • Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, Howell SB: Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. Clin Cancer Res. 2009 Jan 15;15(2):553-60. - Pubmed
DTHybrid score 0.289

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.355
4118 Cytochrome P450 3A5 CYP3A5 0.2272
6030 Cytochrome P450 2B6 CYP2B6 0.2073
6013 Cytochrome P450 2E1 CYP2E1 0.2047
290 Prostaglandin G/H synthase 2 PTGS2 0.2014
6413 Proteasome subunit alpha type-2 PSMA2 0.199
6419 Proteasome subunit beta type-3 PSMB3 0.199
6417 Proteasome subunit alpha type-6 PSMA6 0.199
6415 Proteasome subunit alpha type-4 PSMA4 0.199
6420 Proteasome subunit beta type-4 PSMB4 0.199
6416 Proteasome subunit alpha type-5 PSMA5 0.199
6421 Proteasome subunit beta type-6 PSMB6 0.199
6414 Proteasome subunit alpha type-3 PSMA3 0.199
6412 Proteasome subunit alpha type-1 PSMA1 0.1989
6422 Proteasome subunit beta type-7 PSMB7 0.1989
6418 Proteasome subunit alpha type-7 PSMA7 0.182
6107 Cytochrome P450 3A7 CYP3A7 0.1589
5718 Cytochrome P450 2A6 CYP2A6 0.1333
587 Serum albumin ALB 0.1226
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1209
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0826
1729 Solute carrier family 22 member 6 SLC22A6 0.081
492 Histamine H1 receptor HRH1 0.0777
6106 Cytochrome P450 2C18 CYP2C18 0.0767
1898 Cytochrome P450 1B1 CYP1B1 0.0746
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0688
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0641
824 Sodium-dependent serotonin transporter SLC6A4 0.0637
1757 Myeloperoxidase MPO 0.0598
6165 Copper-transporting ATPase 1 ATP7A 0.0585
6163 Copper-transporting ATPase 2 ATP7B 0.0585
6144 Solute carrier family 22 member 2 SLC22A2 0.0579
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.057
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0564
6145 Solute carrier family 22 member 1 SLC22A1 0.0555
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0549
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0526
908 Glutathione S-transferase theta-1 GSTT1 0.0525
502 5-hydroxytryptamine 2A receptor HTR2A 0.0524
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0523
831 D(2) dopamine receptor DRD2 0.0515
4152 Superoxide dismutase [Cu-Zn] SOD1 0.05
3811 Cytochrome P450 19A1 CYP19A1 0.0492
862 Multidrug resistance-associated protein 1 ABCC1 0.0485
556 Alpha-1A adrenergic receptor ADRA1A 0.0479
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0448
766 Beta-2 adrenergic receptor ADRB2 0.0444
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0443
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0422
896 Glutathione S-transferase Mu 1 GSTM1 0.0411
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0411
318 Alpha-2A adrenergic receptor ADRA2A 0.0408
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0406
904 Glutathione S-transferase P GSTP1 0.0398
468 Cytochrome P450 4A11 CYP4A11 0.0398
6142 Solute carrier family 22 member 8 SLC22A8 0.0397
193 Beta-1 adrenergic receptor ADRB1 0.0395
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0392
136 Estrogen receptor ESR1 0.0385
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0378
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0365
713 Sodium-dependent dopamine transporter SLC6A3 0.0357
2164 Multidrug resistance-associated protein 4 ABCC4 0.0357
590 5-hydroxytryptamine 2C receptor HTR2C 0.0357
118 Organic cation/carnitine transporter 2 SLC22A5 0.0354
320 5-hydroxytryptamine 1A receptor HTR1A 0.0348
776 Bile salt export pump ABCB11 0.0347
23 D(1A) dopamine receptor DRD1 0.0344
3947 Xanthine dehydrogenase/oxidase XDH 0.0343
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0338
275 Arachidonate 5-lipoxygenase ALOX5 0.0337
341 5-hydroxytryptamine 3 receptor HTR3A 0.0332
3941 Amine oxidase [flavin-containing] A MAOA 0.0332
51 Muscarinic acetylcholine receptor M3 CHRM3 0.033
6147 Solute carrier family 22 member 3 SLC22A3 0.0329
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0329
847 Mu-type opioid receptor OPRM1 0.0319
871 Glucocorticoid receptor NR3C1 0.0319
632 Alpha-1B adrenergic receptor ADRA1B 0.0314
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0308
731 HIV-1 protease HIV-1 protease 0.0306
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0295
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0293
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.029
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0289
6143 Solute carrier family 22 member 7 SLC22A7 0.0286
467 Delta-type opioid receptor OPRD1 0.0283
260 Cytochrome P450 51 ERG11 0.028
761 Cytochrome P450 51 ERG11 0.028
3163 Cytochrome P450 51 cyp51 0.028
3923 Cholinesterase BCHE 0.0277
696 Kappa-type opioid receptor OPRK1 0.0272
885 5-hydroxytryptamine 1B receptor HTR1B 0.0265
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0263
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0263
36 Insulin receptor INSR 0.0258
817 DNA topoisomerase 2-alpha TOP2A 0.0256
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0256
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0254
465 Calmodulin CALM1 0.0244
3939 Amine oxidase [flavin-containing] B MAOB 0.0241
1024 Solute carrier family 22 member 11 SLC22A11 0.0237
777 Tumor necrosis factor TNF 0.0232
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0231
638 D(3) dopamine receptor DRD3 0.0229
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0225
6137 Multidrug resistance-associated protein 6 ABCC6 0.0224
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0223
146 Androgen receptor AR 0.0223
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.022
833 Organic cation/carnitine transporter 1 SLC22A4 0.0219
70 Type-1 angiotensin II receptor AGTR1 0.0218
122 P2Y purinoceptor 12 P2RY12 0.0216
789 Alpha-1D adrenergic receptor ADRA1D 0.0216
6031 Cytochrome P450 3A43 CYP3A43 0.0215
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0214
725 5-hydroxytryptamine 1D receptor HTR1D 0.0214
6014 Cytochrome P450 2A13 CYP2A13 0.0213
629 Alpha-2B adrenergic receptor ADRA2B 0.0212
6136 Multidrug resistance-associated protein 5 ABCC5 0.021
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0207
891 Dihydropteroate synthase folP 0.0205
5359 Dihydropteroate synthase folP 0.0205
7175 Dihydropteroate synthase sulI 0.0205
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0205
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0198
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0197
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0197
6182 Cytochrome P450 2J2 CYP2J2 0.0196
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0194
373 Transthyretin TTR 0.0187
6102 Arylamine N-acetyltransferase 2 NAT2 0.0181
378 Alpha-2C adrenergic receptor ADRA2C 0.0178
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0176
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0173
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.017
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0169
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0169
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0169
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0169
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0165
432 D(4) dopamine receptor DRD4 0.0165
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0162
477 DNA topoisomerase 4 subunit A parC 0.0162
886 DNA topoisomerase 4 subunit A parC 0.0162
6226 DNA topoisomerase 4 subunit A parC 0.0162
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0162
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0161
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.016
811 Translocator protein TSPO 0.016
436 5-hydroxytryptamine 2B receptor HTR2B 0.016
404 DNA gyrase subunit A gyrA 0.016
6224 DNA gyrase subunit A gyrA 0.016
6220 Aryl hydrocarbon receptor AHR 0.0157
844 Epidermal growth factor receptor EGFR 0.0156
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0156
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0153
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0148
6148 Multidrug resistance-associated protein 7 ABCC10 0.0148
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0148
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0147
380 Cytochrome P450 17A1 CYP17A1 0.0146
504 Mast/stem cell growth factor receptor KIT 0.0146
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0146
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0145
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0136
571 Melatonin receptor type 1A MTNR1A 0.0136
362 Melatonin receptor type 1B MTNR1B 0.0136
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0135
16 Adenosine A1 receptor ADORA1 0.0134
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0133
614 Progesterone receptor PGR 0.0131
1178 Adenosine A2a receptor ADORA2A 0.0129
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0128
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0128
1010 Cytochrome P450 51A1 CYP51A1 0.0127
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
6141 Sodium/bile acid cotransporter SLC10A1 0.0126
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0124
613 Atrial natriuretic peptide receptor A NPR1 0.0122
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0122
1517 Beta-3 adrenergic receptor ADRB3 0.0122
124 Histamine H2 receptor HRH2 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0121
716 5-hydroxytryptamine 7 receptor HTR7 0.0121
4604 Liver carboxylesterase 1 CES1 0.012
94 5-hydroxytryptamine 4 receptor HTR4 0.012
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0119
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0116
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0116
48 Pyridoxal kinase PDXK 0.0116
365 Dihydrofolate reductase DHFR 0.0115
2381 Dihydrofolate reductase DFR1 0.0115
2833 Dihydrofolate reductase Not Available 0.0115
2931 Dihydrofolate reductase folA 0.0115
3544 Dihydrofolate reductase folA 0.0115
3682 Dihydrofolate reductase folA 0.0115
6642 Dihydrofolate reductase folA 0.0115
6756 Dihydrofolate reductase dfrA 0.0115
1507 Cytochrome c CYCS 0.0115
427 Substance-P receptor TACR1 0.0115
6085 Fatty acid-binding protein, intestinal FABP2 0.0115
474 Acetylcholinesterase ACHE 0.0113
2449 Tubulin alpha-3 chain TUBA1A 0.0113
2499 Tubulin beta-2C chain TUBB2C 0.0113
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0112
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0112
163 D(1B) dopamine receptor DRD5 0.0112
1629 Transcription factor AP-1 JUN 0.0111
738 Monocarboxylate transporter 1 SLC16A1 0.0111
407 Vascular endothelial growth factor receptor 2 KDR 0.0111
606 Cytochrome P450 27, mitochondrial CYP27A1 0.011
228 Beta platelet-derived growth factor receptor PDGFRB 0.011
869 Estrogen receptor beta ESR2 0.0108
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0108
295 Carbonic anhydrase 1 CA1 0.0107
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0106
68 Cannabinoid receptor 1 CNR1 0.0106
6043 Putative G-protein coupled receptor 44 GPR44 0.0106
592 Carbonic anhydrase 4 CA4 0.0105
4203 Histamine N-methyltransferase HNMT 0.0104
4120 NADPH--cytochrome P450 reductase POR 0.0103
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0103
756 Sex hormone-binding globulin SHBG 0.0103
818 50S ribosomal protein L10 rplJ 0.0102
823 Fibroblast growth factor receptor 2 FGFR2 0.0101
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0101
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0099
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0099
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0099
26 Vascular endothelial growth factor receptor 3 FLT4 0.0099
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0098
2183 Fatty acid-binding protein, adipocyte FABP4 0.0098
1648 Elastin ELN 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0097
161 Tubulin beta chain TUBB 0.0097
312 Tubulin beta chain TUB2 0.0097
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0096
4122 Histone deacetylase 2 HDAC2 0.0096
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0096
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0096
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0096
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0096
49 Endothelin B receptor EDNRB 0.0096
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0095
32 Vascular endothelial growth factor receptor 1 FLT1 0.0094
952 Dipeptidyl peptidase 4 DPP4 0.0093
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
634 Squalene monooxygenase SQLE 0.0092
7196 Squalene monooxygenase ERG1 0.0092
921 Glutamate receptor 2 GRIA2 0.0092
183 Vascular endothelial growth factor A VEGFA 0.0092
1656 CYP2B protein CYP2B 0.0091
33 Cystine/glutamate transporter SLC7A11 0.0091
578 Endothelin-1 receptor EDNRA 0.009
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
558 Solute carrier family 12 member 1 SLC12A1 0.0088
3932 Glutathione S-transferase A2 GSTA2 0.0088
528 5-hydroxytryptamine 1E receptor HTR1E 0.0087
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0087
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0086
3312 Fatty acid-binding protein, brain FABP7 0.0086
1050 Bile salt sulfotransferase SULT2A1 0.0085
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0085
4311 tRNA TRDMT1 0.0085
4325 tRNA trmD 0.0085
4328 tRNA trmD 0.0085
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0084
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0084
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
1192 Sulfotransferase 1A1 SULT1A1 0.0083
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0082
1256 5-hydroxytryptamine 6 receptor HTR6 0.0082
185 Vasopressin V1a receptor AVPR1A 0.0082
29 Tubulin beta-1 chain TUBB1 0.0081
106 Cannabinoid receptor 2 CNR2 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
322 Vasopressin V2 receptor AVPR2 0.008
6020 Aldehyde oxidase AOX1 0.0079
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0079
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
357 Carbonic anhydrase 2 CA2 0.0078
1714 Mitogen-activated protein kinase 3 MAPK3 0.0078
1275 Estrogen sulfotransferase SULT1E1 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0078
814 Ryanodine receptor 1 RYR1 0.0077
737 Mineralocorticoid receptor NR3C2 0.0077
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0076
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0076
511 5-hydroxytryptamine 1F receptor HTR1F 0.0075
88 Retinoic acid receptor RXR-beta RXRB 0.0075
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0075
1541 Metalloproteinase mmp20 0.0074
3810 Catechol O-methyltransferase COMT 0.0074
482 Glycine receptor subunit alpha-1 GLRA1 0.0074
273 Apoptosis regulator Bcl-2 BCL2 0.0074
856 Vitamin D3 receptor VDR 0.0074
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0073
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
7 Nitric oxide synthase, inducible NOS2 0.0073
820 Glycine receptor subunit alpha-2 GLRA2 0.0072
130 Prostacyclin synthase PTGIS 0.0072
518 Peroxidase/catalase T katG 0.0072
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.007
6126 Carbonic anhydrase 7 CA7 0.007
581 Cytochrome P450 2R1 CYP2R1 0.007
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
1618 High affinity nerve growth factor receptor NTRK1 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
6103 Arylamine N-acetyltransferase 1 NAT1 0.0065
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0065
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0065
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0065
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0064
1820 Beta-nerve growth factor NGF 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0063
133 Dihydropterate synthase sulI 0.0063
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0062
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0062
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0061
976 Platelet glycoprotein IX GP9 0.006
284 DNA-directed RNA polymerase beta chain rpoB 0.006
5773 DNA-directed RNA polymerase beta chain rpoB 0.006
24 Thymidylate synthase TMP1 0.0059
359 Thymidylate synthase TYMS 0.0059
2626 Thymidylate synthase thyA 0.0059
2729 Thymidylate synthase thyA 0.0059
5352 Thymidylate synthase THYA 0.0059
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0059
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
780 Retinoic acid receptor RXR-gamma RXRG 0.0059
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0059
459 Retinoic acid receptor RXR-alpha RXRA 0.0059
5880 Thrombopoietin receptor MPL 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
2236 Casein kinase II subunit alpha CSNK2A1 0.0058
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
84 Nuclear receptor 0B1 NR0B1 0.0058
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0057
1374 Natriuretic peptides B NPPB 0.0057
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
6044 Serum paraoxonase/lactonase 3 PON3 0.0057
1827 Gap junction alpha-1 protein GJA1 0.0057
1908 Vascular cell adhesion protein 1 VCAM1 0.0057
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0056
703 NADPH azoreductase azr 0.0056
1992 Vitamin D-binding protein GC 0.0056
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0055
6506 Stathmin-4 STMN4 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
3808 Dihydropteroate synthase 2 folP2 0.0054
3601 Dihydropteroate synthase 1 folP1 0.0054
3807 Dihydropteroate synthase 1 folP1 0.0054
850 Vasopressin V1b receptor AVPR1B 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
239 Coagulation factor X F10 0.0052
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0052
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
2981 Phospholipase A2, membrane associated PLA2G2A 0.0052
712 Tubulin alpha chain TUB1 0.0052
3426 Glutamine synthetase glnA 0.0052
3987 Glutamine synthetase GLUL 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
6432 Transporter snf 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
723 Cytosolic phospholipase A2 PLA2G4A 0.005
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.005
5934 Cytochrome P450 26A1 CYP26A1 0.005
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.005
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.005
162 Retinoic acid receptor gamma-1 RARG 0.005
6033 High affinity interleukin-8 receptor A CXCR1 0.0049
563 Thyroid peroxidase TPO 0.0048
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0048
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0048
6149 Solute carrier family 22 member 10 SLC22A10 0.0048
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0048
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0047
3957 Adenosine deaminase ADA 0.0047
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0047
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0047
4192 DNA topoisomerase 2-beta TOP2B 0.0046
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0046
54 Prothrombin F2 0.0046
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0046
174 Sigma 1-type opioid receptor SIGMAR1 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
164 Histamine H4 receptor HRH4 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0045
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0045
3086 Plasmepsin-2 Not Available 0.0045
3856 Fibroblast growth factor receptor 3 FGFR3 0.0045
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0045
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0045
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
6174 50S ribosomal protein L32 rpmF 0.0045
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0045
3809 Estrogen-related receptor gamma ESRRG 0.0044
6131 Carbonic anhydrase 14 CA14 0.0044
153 Dopamine beta-hydroxylase DBH 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
469 Annexin A1 ANXA1 0.0044
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0044
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0044
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0044
3830 Calreticulin CALR 0.0043
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
1483 Membrane copper amine oxidase AOC3 0.0043
268 Adenosine A2b receptor ADORA2B 0.0043
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
705 Glutamate receptor 1 GRIA1 0.0043
165 FL cytokine receptor FLT3 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
1176 Mitogen-activated protein kinase 1 MAPK1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
489 Monocarboxylate transporter 2 SLC16A7 0.0041
6034 Hydroxyindole O-methyltransferase ASMT 0.0041
6035 Nuclear receptor ROR-beta RORB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6036 Eosinophil peroxidase EPX 0.0041
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.004
3937 Fatty-acid amide hydrolase FAAH 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.004
936 Ephrin type-A receptor 2 EPHA2 0.004
569 Retinal dehydrogenase 2 ALDH1A2 0.0039
6138 Multidrug resistance protein 3 ABCB4 0.0039
4132 Chloride channel protein ClC-Ka CLCNKA 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
251 Alcohol dehydrogenase 1A ADH1A 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
822 Aldose reductase AKR1B1 0.0038
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0038
85 Growth hormone receptor GHR 0.0038
319 Opioid receptor, sigma 1 OPRS1 0.0037
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0037
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0037
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0037
611 Retinal dehydrogenase 1 ALDH1A1 0.0037
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0037
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
5787 Angiopoietin-1 receptor TEK 0.0036
1864 RET proto-oncogene RET 0.0036
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0036
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0036
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
1630 Integrin beta-2 ITGB2 0.0035
765 Indoleamine 2,3-dioxygenase IDO1 0.0035
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
444 Alcohol dehydrogenase 1B ADH1B 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
1039 Histone deacetylase 9 HDAC9 0.0034
267 Plasminogen activator inhibitor 1 SERPINE1 0.0034
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0034
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0034
751 Potassium channel subfamily K member 6 KCNK6 0.0034
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0033
229 Retinoic acid receptor beta RARB 0.0033
537 ATP synthase delta chain, mitochondrial ATP5D 0.0033
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0033
2021 Thrombomodulin THBD 0.0032
730 Retinoic acid receptor alpha RARA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
2207 Rhodopsin RHO 0.0032
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0032
719 Retinoic acid receptor responder protein 1 RARRES1 0.0032
770 Retinoic acid-induced protein 3 GPRC5A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
172 Potassium channel subfamily K member 1 KCNK1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
6221 Steroid hormone receptor ERR1 ESRRA 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
517 Alcohol dehydrogenase 1C ADH1C 0.003
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.003
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
3917 Methylenetetrahydrofolate reductase MTHFR 0.0029
1569 G1/S-specific cyclin-D1 CCND1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
4217 Telomerase reverse transcriptase TERT 0.0028
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0028
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0028
1063 Signal transducer and activator of transcription 5B STAT5B 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
572 Integrin alpha-L ITGAL 0.0027
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0027
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
6500 Phospholipase A2 PLA2G1B 0.0026
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0026
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0025
3913 Glutamic acid decarboxylase GAD65 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
759 Free fatty acid receptor 1 FFAR1 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6122 Carbonic anhydrase 3 CA3 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4226 Uridine phosphorylase 2 UPP2 0.0023
6048 Troponin C, skeletal muscle TNNC2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
1341 Histamine H3 receptor HRH3 0.0023
484 Tyrosine-protein kinase ABL2 ABL2 0.0022
1792 Tissue-type plasminogen activator PLAT 0.0022
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0022
5798 Mitogen-activated protein kinase 11 MAPK11 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
3404 Exotoxin A eta 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
2091 Endoplasmin HSP90B1 0.0021
735 Alanine aminotransferase 1 GPT 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3904 Alanine aminotransferase 2 GPT2 0.0021
1053 BC269730_2 FADS1 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0021
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
422 Vitamin K-dependent protein C PROC 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
594 Thyroxine-binding globulin SERPINA7 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
1243 Cathepsin D CTSD 0.0019
1650 Heme carrier protein 1 SLC46A1 0.0019
6218 Pannexin-1 PANX1 0.0019
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
2216 Fibroblast growth factor receptor 4 FGFR4 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6042 Prostaglandin reductase 2 PTGR2 0.0018
1253 Interferon gamma IFNG 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
291 Nitric-oxide synthase, endothelial NOS3 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
798 Osteocalcin BGLAP 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
3007 Carbonic anhydrase 12 CA12 0.0016
4205 Carbonic anhydrase 9 CA9 0.0016
3233 Bile acid receptor NR1H4 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
369 Coagulation factor VII F7 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1313 Lactoylglutathione lyase GLO1 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6859 Protein S100-A4 S100A4 0.0014
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
4386 Hemoglobin-like protein HbN glbN 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2298 Cytochrome P450-cam camC 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
3221 Cytochrome c4 cc4 0.001
76 Nitric-oxide synthase, brain NOS1 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6677 Myelin P2 protein PMP2 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
4954 Soluble cytochrome b558 Not Available 0.0009
4916 Cyanoglobin glbN 0.0009
4934 Cytochrome c-551 nirM 0.0009
5218 Cytochrome c-551 nirM 0.0009
4947 Bacterial hemoglobin vhb 0.0009
4943 Cytochrome c6 petJ 0.0009
4915 Cytochrome c-550 psbV 0.0009
4959 Cytochrome c-550 psbV 0.0009
5216 Cytochrome c-550 psbV 0.0009
4925 Cytochrome c-type protein SHP shp 0.0009
4905 Cytochrome c2 Not Available 0.0009
4939 Cytochrome c2 cycA 0.0009
4964 Cytochrome c2 cycA 0.0009
4979 Cytochrome c2 cycA 0.0009
6673 Cytochrome c2 cycA 0.0009
4975 Cytochrome c-556 RPA3973 0.0009
4994 Hemoglobin-like protein HbO glbO 0.0009
4936 Cytochrome c2 iso-2 Not Available 0.0009
4984 Neuroglobin NGB 0.0009
4998 Hemoglobin-like protein yjbI yjbI 0.0009
4942 Diheme cytochrome c napB napB 0.0009
4961 Hemophore HasA hasA 0.0009
4909 CooA protein cooA 0.0009
4981 Iron-starvation protein PigA pigA 0.0009
5000 HemO hemO 0.0009
644 Heme oxygenase 2 HMOX2 0.0009
4982 Heme oxygenase 2 pbsA2 0.0009
3116 Bacterioferritin bfr 0.0009
4906 Bacterioferritin bfr 0.0009
4965 Bacterioferritin bfr 0.0009
4904 Cytochrome c family protein GSU1996 0.0009
4907 Cytochrome c-L moxG 0.0009
6865 Cytochrome c-L moxG 0.0009
4910 Cytoglobin CYGB 0.0009
4976 Apocytochrome f petA 0.0009
6407 Apocytochrome f petA 0.0009
4971 Nonaheme cytochrome c hmcA 0.0009
4935 Cytochrome c-554 cycA1 0.0009
4989 Cytochrome c551 peroxidase ccp 0.0009
5222 Cytochrome c551 peroxidase ccpA 0.0009
4937 Cytochrome oxidase subunit II rcoxA 0.0009
4926 Heme-based aerotactic transducer hemAT hemAT 0.0009
4764 Cytochrome P450 165C4 CYP165C4 0.0009
4999 Cytochrome P450 165B3 CYP165B3 0.0009
4960 Putative cytochrome P450-family protein SCO7417 0.0009
4931 Cytochrome P450 167A1 CYP167A1 0.0009
4972 P450cin cinA 0.0009
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0009
4993 Hydroxylamine oxidoreductase hao1 0.0009
4922 Cytochrome c, putative SO_4144 0.0009
4903 Methyl-accepting chemotaxis protein Tar4 0.0009
4952 Catalase/peroxidase katA 0.0009
3093 Catalase HPII katE 0.0009
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
1184 Interferon beta IFNB1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
4920 Peroxidase/catalase katG 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
4990 PpcA ppcA 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
3670 Soluble cytochrome b562 precursor cybC 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
3411 Cytochrome P450 121 cyp121 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
2430 Chondroitinase B cslB 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
4608 Putative cytochrome P450 SCO1207 0.0005
4963 Putative cytochrome P450 SCO2884 0.0005
6254 Putative cytochrome P450 SCO6998 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
358 Cystathionine beta-synthase CBS 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
693 Hemoglobin subunit beta HBB 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
3689 Endoglucanase A celA 0.0004
3814 Complement C1r subcomponent C1R 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1439 Lactotransferrin LTF 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
↑