DT-Web

DB00758 - Clopidogrel


Identification
Name Clopidogrel
Accession Number DB00758 (APRD00444)
Type small molecule
Description Clopidogrel, an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to inhibit blood clots in a variety of conditions such as peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Clopidogrel is sold under the name Plavix by Sanofi and Bristol-Myers Squibb. The drug is an irreversible inhibitor of the P2Y12 adenosine diphosphate receptor found on the membranes of platelet cells. Clopidogrel use is associated with several serious adverse drug reactions such as severe neutropenia, various forms of hemorrhage, and cardiovascular edema.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 321.822
Groups approved
Monoisotopic Weight 321.059027158
Pharmacology
Indication For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Mechanism of action The active metabolite of clopidogrel prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. he drug specifically and irreversibly inhibits the P2Y12 subtype of ADP receptor, which is important in aggregation of platelets and cross-linking by the protein fibrin. No direct interference occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of clopidogrel.
Absorption Absorption is at least 50% based on urinary excretion of clopidogrel-related metabolites. Bioavailability has not been found to be affected by food.
Protein binding 98%
Biotransformation Hepatic, extensive and rapid, by hydrolysis to the main circulating metabolite, a carboxylic acid derivative, which accounts for approximately 85% of the circulating drug-related compounds. A glucuronic acid derivative of the carboxylic acid derivative has also been found in plasma and urine. Neither the parent compound nor the carboxylic acid derivative has a platelet inhibiting effect.
Route of elimination Following an oral dose of 14C-labeled clopidogrel in humans, approximately 50% of total radioactivity was excreted in urine and approximately 46% in feces over the 5 days post-dosing.
Toxicity A single dose of clopidogrel at 1500 or 2000 mg/kg was lethal to mice and rats, with 3000 mg/kg lethal to baboons. Symptoms included vomiting, breathing difficulty, hemorrhage, and prostration.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bortezomib Moderate CYP2C19 Inhibitors like bortezomib may decrease serum concentrations of the active metabolite(s) of Clopidogrel. Avoid concurrent use of moderate CYP2C19 inhibitors with clopidogrel whenever possible. If such a combination must be used, monitor closely for evidence of reduced clinical response to clopidogrel.
Drotrecogin alfa Antiplatelet agents such as clopidogrel may enhance the adverse/toxic effect of Drotrecogin Alfa. Bleeding may occur. Increase monitoring for signs/symptoms of bleeding during concomitant therapy. If possible, avoid use of drotrecogin within 7 days of use of any IIb/IIIa antagonists, higher dose aspirin (more than 650 mg/day), or use of other antiplatelet agents.
Esomeprazole Esomeprazole may decrease serum concentrations of the active metabolite(s) of clopidogrel. Due to the possible risk for impaired clopidogrel effectiveness with this combination, clinicians should carefully consider the need for concurrent esomeprazole therapy in patients receiving clopidogrel. Monitor response to clopidogrel closely when using clopidogrel with esomeprazole. Whether there are differences among individual proton pump inhibitors is unclear. Other acid-lowering therapies (e.g., H2-receptor antagonists, antacids, etc.) do not appear to share this interaction with clopidogrel.
Etravirine Clopidogrel, when used concomitantly with etravirine (a CYP2C19 inhibitor), may experience a decrease in the serum concentrations of it's active metabolites. Caution and close monitoring for decreased efficacy of clopidogrel is recommended.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Lansoprazole Lansoprazole may decrease serum concentrations of the active metabolite(s) of clopidogrel. Due to the possible risk for impaired clopidogrel effectiveness with this combination, clinicians should carefully consider the need for concurrent lansoprazole therapy in patients receiving clopidogrel. Monitor response to clopidogrel closely when using clopidogrel with lansoprazole. Whether there are differences among individual proton pump inhibitors is unclear. Other acid-lowering therapies (e.g., H2-receptor antagonists, antacids, etc.) do not appear to share this interaction with clopidogrel.
Omeprazole Omeprazole may decrease serum concentrations of the active metabolite(s) of clopidogrel. Clopidogrel prescribing information recommends avoiding concurrent use with omeprazole, due to the possibility that combined use may result in decreased clopidogrel effectiveness.
Pantoprazole Pantoprazole may decrease serum concentrations of the active metabolite(s) of clopidogrel. Due to the possible risk for impaired clopidogrel effectiveness with this combination, clinicians should carefully consider the need for concurrent pantoprazole therapy in patients receiving clopidogrel. Monitor response to clopidogrel closely when using clopidogrel with pantoprazole. Whether there are differences among individual proton pump inhibitors is unclear. Other acid-lowering therapies (e.g., H2-receptor antagonists, antacids, etc.) do not appear to share this interaction with clopidogrel.
Rabeprazole Rabeprazole may decrease serum concentrations of the active metabolite(s) of clopidogrel. Due to the possible risk for impaired clopidogrel effectiveness with this combination, clinicians should carefully consider the need for concurrent rabeprazole therapy in patients receiving clopidogrel. Monitor response to clopidogrel closely when using clopidogrel with rabeprazole. Whether there are differences among individual proton pump inhibitors is unclear. Other acid-lowering therapies (e.g., H2-receptor antagonists, antacids, etc.) do not appear to share this interaction with clopidogrel.
Rivaroxaban Antiplatelet agents such as clopidogrel may enhance the anticoagulant effect of rivaroxaban. Avoid concurrent use of clopidogrel with rivaroxaban unless the anticipated benefits outweigh the risks of bleeding. Canadian rivaroxaban labeling recommends avoiding concurrent use with any antiplatelet agent, while the U.S. rivaroxaban labeling recommends caution and increased monitoring if used with any other antiplatelet agent. Any combined use should only be undertaken with increased monitoring for evidence of bleeding.
Treprostinil The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Clopidogrel. Monitor for increased bleeding during concomitant thearpy.
Warfarin Increased bleed risk may occur as a result of additive anticoagulant effects. Increase monitoring for signs and symptoms of bleeding during concomitant therapy.
Food Interactions Not Available

Targets


P2Y purinoceptor 12
Name P2Y purinoceptor 12
Gene Name P2RY12
Pharmacological action yes
Actions antagonist
References
  • Dorsam RT, Murugappan S, Ding Z, Kunapuli SP: Clopidogrel: Interactions with the P2Y12 Receptor and Clinical Relevance. Hematology. 2003 Dec;8(6):359-65. - Pubmed
  • Herbert JM, Savi P: P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22. - Pubmed
  • Taubert D, Kastrati A, Harlfinger S, Gorchakova O, Lazar A, von Beckerath N, Schomig A, Schomig E: Pharmacokinetics of clopidogrel after administration of a high loading dose. Thromb Haemost. 2004 Aug;92(2):311-6. - Pubmed
  • Wang L, Jacobsen SE, Bengtsson A, Erlinge D: P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells. BMC Immunol. 2004 Aug 3;5:16. - Pubmed
  • Wihlborg AK, Wang L, Braun OO, Eyjolfsson A, Gustafsson R, Gudbjartsson T, Erlinge D: ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels. Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1810-5. Epub 2004 Aug 12. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Gladding P, Webster M, Zeng I, Farrell H, Stewart J, Ruygrok P, Ormiston J, El-Jack S, Armstrong G, Kay P, Scott D, Gunes A, Dahl ML: The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial. JACC Cardiovasc Interv. 2008 Dec;1(6):620-7. - Pubmed
  • Savi P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P, Herbert JM: The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11069-74. Epub 2006 Jul 11. - Pubmed
  • van Gestel MA, Heemskerk JW, Slaaf DW, Heijnen VV, Reneman RS, oude Egbrink MG: In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability. Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):518-23. Epub 2003 Jan 23. - Pubmed
DTHybrid score 0.3485

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Saw J, Steinhubl SR, Berger PB, Kereiakes DJ, Serebruany VL, Brennan D, Topol EJ: Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation. 2003 Aug 26;108(8):921-4. Epub 2003 Aug 18. - Pubmed
  • Neubauer H, Gunesdogan B, Hanefeld C, Spiecker M, Mugge A: Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study. Eur Heart J. 2003 Oct;24(19):1744-9. - Pubmed
  • Lau WC, Gurbel PA, Watkins PB, Neer CJ, Hopp AS, Carville DG, Guyer KE, Tait AR, Bates ER: Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation. 2004 Jan 20;109(2):166-71. Epub 2004 Jan 5. - Pubmed
  • Mukherjee D, Kline-Rogers E, Fang J, Munir K, Eagle KA: Lack of clopidogrel-CYP3A4 statin interaction in patients with acute coronary syndrome. Heart. 2005 Jan;91(1):23-6. - Pubmed
  • Poulsen TS, Vinholt P, Mickley H, Korsholm L, Kristensen SR, Damkier P: Existence of a clinically relevant interaction between clopidogrel and HMG-CoA reductase inhibitors? Re-evaluating the evidence. Basic Clin Pharmacol Toxicol. 2005 Feb;96(2):103-10. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Clarke TA, Waskell LA: The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab Dispos. 2003 Jan;31(1):53-9. - Pubmed
DTHybrid score 0.8171
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inhibitor
References
  • Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3977
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3912
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5176
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6355
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4883
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.426
Liver carboxylesterase 1
Name Liver carboxylesterase 1
Gene Name CES1
Actions substrate
References
  • Zhu HJ, Wang X, Gawronski BE, Brinda BJ, Angiolillo DJ, Markowitz JS: Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation. J Pharmacol Exp Ther. 2013 Mar;344(3):665-72. doi: 10.1124/jpet.112.201640. Epub 2012 Dec 28. - Pubmed
DTHybrid score 0.5512

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Taubert D, von Beckerath N, Grimberg G, Lazar A, Jung N, Goeser T, Kastrati A, Schomig A, Schomig E: Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther. 2006 Nov;80(5):486-501. - Pubmed
DTHybrid score 0.5224

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.3908
6107 Cytochrome P450 3A7 CYP3A7 0.2429
6013 Cytochrome P450 2E1 CYP2E1 0.2022
6024 Cytochrome P450 1A1 CYP1A1 0.1599
587 Serum albumin ALB 0.1509
5718 Cytochrome P450 2A6 CYP2A6 0.1307
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1282
20 Prostaglandin G/H synthase 1 PTGS1 0.1143
527 Prostacyclin receptor PTGIR 0.1081
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0927
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0924
6106 Cytochrome P450 2C18 CYP2C18 0.0826
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0734
862 Multidrug resistance-associated protein 1 ABCC1 0.0733
492 Histamine H1 receptor HRH1 0.0717
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0681
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0664
824 Sodium-dependent serotonin transporter SLC6A4 0.0637
290 Prostaglandin G/H synthase 2 PTGS2 0.0604
130 Prostacyclin synthase PTGIS 0.0603
3811 Cytochrome P450 19A1 CYP19A1 0.0603
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0594
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0589
1729 Solute carrier family 22 member 6 SLC22A6 0.0577
1898 Cytochrome P450 1B1 CYP1B1 0.0538
6145 Solute carrier family 22 member 1 SLC22A1 0.0521
540 Sodium-dependent noradrenaline transporter SLC6A2 0.052
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0519
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0519
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0511
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0507
502 5-hydroxytryptamine 2A receptor HTR2A 0.0501
871 Glucocorticoid receptor NR3C1 0.0493
556 Alpha-1A adrenergic receptor ADRA1A 0.0479
831 D(2) dopamine receptor DRD2 0.0477
776 Bile salt export pump ABCB11 0.0474
6142 Solute carrier family 22 member 8 SLC22A8 0.0472
6144 Solute carrier family 22 member 2 SLC22A2 0.0459
136 Estrogen receptor ESR1 0.0458
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0456
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.043
2164 Multidrug resistance-associated protein 4 ABCC4 0.043
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0406
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0405
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.04
731 HIV-1 protease HIV-1 protease 0.0396
198 Sodium channel protein type 10 subunit alpha SCN10A 0.039
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0388
318 Alpha-2A adrenergic receptor ADRA2A 0.0387
6143 Solute carrier family 22 member 7 SLC22A7 0.0366
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0365
847 Mu-type opioid receptor OPRM1 0.0361
260 Cytochrome P450 51 ERG11 0.0361
761 Cytochrome P450 51 ERG11 0.0361
3163 Cytochrome P450 51 cyp51 0.0361
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0356
118 Organic cation/carnitine transporter 2 SLC22A5 0.0351
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0351
6606 Platelet-activating factor acetylhydrolase IB subunit gamma PAFAH1B3 0.0348
4175 Platelet-activating factor acetylhydrolase PLA2G7 0.0348
713 Sodium-dependent dopamine transporter SLC6A3 0.0346
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0341
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0338
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0327
3941 Amine oxidase [flavin-containing] A MAOA 0.0325
590 5-hydroxytryptamine 2C receptor HTR2C 0.0324
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0322
320 5-hydroxytryptamine 1A receptor HTR1A 0.0321
632 Alpha-1B adrenergic receptor ADRA1B 0.0321
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.032
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0319
23 D(1A) dopamine receptor DRD1 0.0316
6031 Cytochrome P450 3A43 CYP3A43 0.0311
817 DNA topoisomerase 2-alpha TOP2A 0.0308
468 Cytochrome P450 4A11 CYP4A11 0.0305
467 Delta-type opioid receptor OPRD1 0.0304
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0303
1757 Myeloperoxidase MPO 0.03
766 Beta-2 adrenergic receptor ADRB2 0.0299
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0298
341 5-hydroxytryptamine 3 receptor HTR3A 0.0295
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0295
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0292
696 Kappa-type opioid receptor OPRK1 0.029
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0289
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0286
465 Calmodulin CALM1 0.0283
3923 Cholinesterase BCHE 0.0282
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.028
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0279
6182 Cytochrome P450 2J2 CYP2J2 0.0277
6147 Solute carrier family 22 member 3 SLC22A3 0.0269
193 Beta-1 adrenergic receptor ADRB1 0.0261
36 Insulin receptor INSR 0.0258
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0258
3939 Amine oxidase [flavin-containing] B MAOB 0.0249
885 5-hydroxytryptamine 1B receptor HTR1B 0.0244
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0241
146 Androgen receptor AR 0.0238
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0235
833 Organic cation/carnitine transporter 1 SLC22A4 0.0234
232 Corticosteroid-binding globulin SERPINA6 0.0232
789 Alpha-1D adrenergic receptor ADRA1D 0.023
638 D(3) dopamine receptor DRD3 0.0229
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0228
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0227
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0222
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0222
725 5-hydroxytryptamine 1D receptor HTR1D 0.0216
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0215
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0214
6137 Multidrug resistance-associated protein 6 ABCC6 0.0212
844 Epidermal growth factor receptor EGFR 0.0209
1024 Solute carrier family 22 member 11 SLC22A11 0.0206
477 DNA topoisomerase 4 subunit A parC 0.0205
886 DNA topoisomerase 4 subunit A parC 0.0205
6226 DNA topoisomerase 4 subunit A parC 0.0205
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0203
404 DNA gyrase subunit A gyrA 0.0202
6224 DNA gyrase subunit A gyrA 0.0202
504 Mast/stem cell growth factor receptor KIT 0.0201
6148 Multidrug resistance-associated protein 7 ABCC10 0.02
70 Type-1 angiotensin II receptor AGTR1 0.0199
614 Progesterone receptor PGR 0.0197
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0196
6141 Sodium/bile acid cotransporter SLC10A1 0.0196
244 Angiotensin-converting enzyme ACE 0.0194
629 Alpha-2B adrenergic receptor ADRA2B 0.0193
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0192
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.019
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0188
891 Dihydropteroate synthase folP 0.0188
5359 Dihydropteroate synthase folP 0.0188
7175 Dihydropteroate synthase sulI 0.0188
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0188
869 Estrogen receptor beta ESR2 0.0187
6220 Aryl hydrocarbon receptor AHR 0.0184
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0181
777 Tumor necrosis factor TNF 0.0181
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.018
811 Translocator protein TSPO 0.018
4120 NADPH--cytochrome P450 reductase POR 0.0179
6136 Multidrug resistance-associated protein 5 ABCC5 0.0177
818 50S ribosomal protein L10 rplJ 0.0176
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0174
756 Sex hormone-binding globulin SHBG 0.0174
124 Histamine H2 receptor HRH2 0.0168
407 Vascular endothelial growth factor receptor 2 KDR 0.0167
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0166
24 Thymidylate synthase TMP1 0.0166
359 Thymidylate synthase TYMS 0.0166
2626 Thymidylate synthase thyA 0.0166
2729 Thymidylate synthase thyA 0.0166
5352 Thymidylate synthase THYA 0.0166
26 Vascular endothelial growth factor receptor 3 FLT4 0.0165
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0165
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0164
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0163
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0163
378 Alpha-2C adrenergic receptor ADRA2C 0.0163
32 Vascular endothelial growth factor receptor 1 FLT1 0.0158
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0155
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0155
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0155
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0155
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0153
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.015
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0149
29 Tubulin beta-1 chain TUBB1 0.0149
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0148
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0147
2178 Metabotropic glutamate receptor 5 GRM5 0.0147
737 Mineralocorticoid receptor NR3C2 0.0146
1656 CYP2B protein CYP2B 0.0146
228 Beta platelet-derived growth factor receptor PDGFRB 0.0145
54 Prothrombin F2 0.0145
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0145
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0145
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0145
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0145
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0143
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0143
427 Substance-P receptor TACR1 0.0142
380 Cytochrome P450 17A1 CYP17A1 0.0141
1010 Cytochrome P450 51A1 CYP51A1 0.0141
1192 Sulfotransferase 1A1 SULT1A1 0.0138
432 D(4) dopamine receptor DRD4 0.0138
952 Dipeptidyl peptidase 4 DPP4 0.0138
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0137
3611 Cytidine deaminase cdd 0.0135
3707 Cytidine deaminase cdd 0.0135
4211 Cytidine deaminase CDA 0.0135
436 5-hydroxytryptamine 2B receptor HTR2B 0.0135
161 Tubulin beta chain TUBB 0.0135
312 Tubulin beta chain TUB2 0.0135
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0134
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0134
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0134
3947 Xanthine dehydrogenase/oxidase XDH 0.0133
3639 Thymidine phosphorylase deoA 0.0131
3936 Thymidine phosphorylase TYMP 0.0131
716 5-hydroxytryptamine 7 receptor HTR7 0.0128
6102 Arylamine N-acetyltransferase 2 NAT2 0.0128
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
6014 Cytochrome P450 2A13 CYP2A13 0.0121
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0121
4148 Serine/threonine-protein kinase mTOR MTOR 0.0121
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.012
1141 Sialidase-1 NEU1 0.012
64 Neuraminidase NA 0.012
641 Neuraminidase NA 0.012
2676 Neuraminidase NA 0.012
3026 Neuraminidase NA 0.012
3519 Neuraminidase NA 0.012
6007 Neuraminidase NA 0.012
1353 DNA topoisomerase 1 TOP1 0.012
3552 DNA topoisomerase 1 topA 0.012
94 5-hydroxytryptamine 4 receptor HTR4 0.0119
705 Glutamate receptor 1 GRIA1 0.0119
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0119
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0116
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0115
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0115
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0115
16 Adenosine A1 receptor ADORA1 0.0114
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0114
174 Sigma 1-type opioid receptor SIGMAR1 0.0111
6020 Aldehyde oxidase AOX1 0.011
373 Transthyretin TTR 0.011
1178 Adenosine A2a receptor ADORA2A 0.011
958 Insulin-like growth factor 1 receptor IGF1R 0.0109
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0109
365 Dihydrofolate reductase DHFR 0.0108
2381 Dihydrofolate reductase DFR1 0.0108
2833 Dihydrofolate reductase Not Available 0.0108
2931 Dihydrofolate reductase folA 0.0108
3544 Dihydrofolate reductase folA 0.0108
3682 Dihydrofolate reductase folA 0.0108
6642 Dihydrofolate reductase folA 0.0108
6756 Dihydrofolate reductase dfrA 0.0108
6085 Fatty acid-binding protein, intestinal FABP2 0.0107
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0106
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0105
482 Glycine receptor subunit alpha-1 GLRA1 0.0105
921 Glutamate receptor 2 GRIA2 0.0104
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0103
5482 Sialidase-2 NEU2 0.0102
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0101
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0101
474 Acetylcholinesterase ACHE 0.01
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0099
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0099
2539 Tubulin alpha-1 chain TUBA4A 0.0098
275 Arachidonate 5-lipoxygenase ALOX5 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0097
5300 Antigen peptide transporter 1 TAP1 0.0096
295 Carbonic anhydrase 1 CA1 0.0096
49 Endothelin B receptor EDNRB 0.0096
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0095
273 Apoptosis regulator Bcl-2 BCL2 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
738 Monocarboxylate transporter 1 SLC16A1 0.0093
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0093
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0092
239 Coagulation factor X F10 0.0091
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0091
578 Endothelin-1 receptor EDNRA 0.009
823 Fibroblast growth factor receptor 2 FGFR2 0.009
592 Carbonic anhydrase 4 CA4 0.009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0089
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
4122 Histone deacetylase 2 HDAC2 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
4237 50S ribosomal protein L22 rplV 0.0087
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0087
88 Retinoic acid receptor RXR-beta RXRB 0.0086
6138 Multidrug resistance protein 3 ABCB4 0.0086
1618 High affinity nerve growth factor receptor NTRK1 0.0084
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
163 D(1B) dopamine receptor DRD5 0.0082
6043 Putative G-protein coupled receptor 44 GPR44 0.008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.008
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.008
165 FL cytokine receptor FLT3 0.008
319 Opioid receptor, sigma 1 OPRS1 0.0079
3810 Catechol O-methyltransferase COMT 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
3809 Estrogen-related receptor gamma ESRRG 0.0077
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0077
4203 Histamine N-methyltransferase HNMT 0.0077
528 5-hydroxytryptamine 1E receptor HTR1E 0.0076
284 DNA-directed RNA polymerase beta chain rpoB 0.0076
5773 DNA-directed RNA polymerase beta chain rpoB 0.0076
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0076
1256 5-hydroxytryptamine 6 receptor HTR6 0.0075
1541 Metalloproteinase mmp20 0.0074
4238 50S ribosomal protein L4 rplD 0.0074
5578 50S ribosomal protein L4 rplD 0.0074
6173 50S ribosomal protein L4 rplD 0.0074
6219 50S ribosomal protein L4 rplD 0.0074
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0074
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0074
3932 Glutathione S-transferase A2 GSTA2 0.0073
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0072
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0072
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0072
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0072
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0072
814 Ryanodine receptor 1 RYR1 0.0072
5414 Fiber protein L5 0.0071
5418 Fiber protein L5 0.0071
1756 E-selectin SELE 0.0071
780 Retinoic acid receptor RXR-gamma RXRG 0.0071
6174 50S ribosomal protein L32 rpmF 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0071
511 5-hydroxytryptamine 1F receptor HTR1F 0.007
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.007
2449 Tubulin alpha-3 chain TUBA1A 0.007
1852 Microtubule-associated protein 2 MAP2 0.007
537 ATP synthase delta chain, mitochondrial ATP5D 0.0068
4311 tRNA TRDMT1 0.0068
4325 tRNA trmD 0.0068
4328 tRNA trmD 0.0068
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0068
68 Cannabinoid receptor 1 CNR1 0.0068
723 Cytosolic phospholipase A2 PLA2G4A 0.0067
183 Vascular endothelial growth factor A VEGFA 0.0067
357 Carbonic anhydrase 2 CA2 0.0067
768 FK506-binding protein 1A FKBP1A 0.0067
469 Annexin A1 ANXA1 0.0067
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0067
208 DNA-directed RNA polymerase beta' chain rpoC 0.0067
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0067
84 Nuclear receptor 0B1 NR0B1 0.0066
2981 Phospholipase A2, membrane associated PLA2G2A 0.0066
1629 Transcription factor AP-1 JUN 0.0066
856 Vitamin D3 receptor VDR 0.0066
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0066
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0066
6044 Serum paraoxonase/lactonase 3 PON3 0.0066
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0065
2499 Tubulin beta-2C chain TUBB2C 0.0065
904 Glutathione S-transferase P GSTP1 0.0065
6168 Solute carrier family 22 member 16 SLC22A16 0.0065
1517 Beta-3 adrenergic receptor ADRB3 0.0064
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0064
6432 Transporter snf 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0063
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
153 Dopamine beta-hydroxylase DBH 0.0062
3629 Endo-N-acetylneuraminidase Not Available 0.0062
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0062
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0062
518 Peroxidase/catalase T katG 0.0061
5416 Coat protein VP1 Not Available 0.0061
1130 Lithostathine 1 alpha REG1A 0.0061
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0061
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0061
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0061
162 Retinoic acid receptor gamma-1 RARG 0.0061
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.006
4103 Proteasome subunit beta type 2 PSMB2 0.006
4102 Proteasome subunit beta type 5 PSMB5 0.006
4101 Proteasome subunit beta type 1 PSMB1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
1196 Complement decay-accelerating factor CD55 0.006
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0059
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0059
1630 Integrin beta-2 ITGB2 0.0059
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0059
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0059
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0059
563 Thyroid peroxidase TPO 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
581 Cytochrome P450 2R1 CYP2R1 0.0058
5880 Thrombopoietin receptor MPL 0.0058
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0058
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0058
2324 Botulinum neurotoxin type B botB 0.0057
3547 Enterotoxin type B entB 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
2058 P-selectin SELP 0.0056
551 Carnitine O-acetyltransferase CRAT 0.0056
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0056
33 Cystine/glutamate transporter SLC7A11 0.0056
1275 Estrogen sulfotransferase SULT1E1 0.0055
131 Synaptic vesicular amine transporter SLC18A2 0.0055
5787 Angiopoietin-1 receptor TEK 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0054
3856 Fibroblast growth factor receptor 3 FGFR3 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
6146 High affinity copper uptake protein 1 SLC31A1 0.0054
976 Platelet glycoprotein IX GP9 0.0054
1483 Membrane copper amine oxidase AOC3 0.0054
3086 Plasmepsin-2 Not Available 0.0053
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0053
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0053
1050 Bile salt sulfotransferase SULT2A1 0.0053
2112 Toll-like receptor 9 TLR9 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0052
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0052
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0052
2808 Chloramphenicol acetyltransferase 3 cat3 0.0052
936 Ephrin type-A receptor 2 EPHA2 0.0052
6126 Carbonic anhydrase 7 CA7 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0051
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0051
634 Squalene monooxygenase SQLE 0.005
7196 Squalene monooxygenase ERG1 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
2570 Tetanus toxin tetX 0.0049
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0049
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0048
7 Nitric oxide synthase, inducible NOS2 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
4192 DNA topoisomerase 2-beta TOP2B 0.0047
3601 Dihydropteroate synthase 1 folP1 0.0047
3807 Dihydropteroate synthase 1 folP1 0.0047
3808 Dihydropteroate synthase 2 folP2 0.0047
2417 Chloramphenicol acetyltransferase cat 0.0047
3278 Chloramphenicol acetyltransferase cat 0.0047
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0047
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0047
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0047
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0047
2810 Dr hemagglutinin structural subunit draA 0.0047
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0046
517 Alcohol dehydrogenase 1C ADH1C 0.0046
173 Toll-like receptor 7 TLR7 0.0046
1992 Vitamin D-binding protein GC 0.0045
6149 Solute carrier family 22 member 10 SLC22A10 0.0045
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0045
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0045
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0044
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0044
5934 Cytochrome P450 26A1 CYP26A1 0.0044
908 Glutathione S-transferase theta-1 GSTT1 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
3957 Adenosine deaminase ADA 0.0044
6042 Prostaglandin reductase 2 PTGR2 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
2723 Cholera enterotoxin subunit B ctxB 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
4773 Deoxycytidine kinase DCK 0.0041
106 Cannabinoid receptor 2 CNR2 0.004
6824 Tyrosine-protein kinase Lyn LYN 0.004
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.004
1039 Histone deacetylase 9 HDAC9 0.0039
267 Plasminogen activator inhibitor 1 SERPINE1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0038
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0038
85 Growth hormone receptor GHR 0.0038
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
719 Retinoic acid receptor responder protein 1 RARRES1 0.0037
770 Retinoic acid-induced protein 3 GPRC5A 0.0037
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
3913 Glutamic acid decarboxylase GAD65 0.0037
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0037
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0036
251 Alcohol dehydrogenase 1A ADH1A 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0036
444 Alcohol dehydrogenase 1B ADH1B 0.0035
6221 Steroid hormone receptor ERR1 ESRRA 0.0035
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0035
572 Integrin alpha-L ITGAL 0.0035
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0035
2391 Ferrochelatase hemH 0.0035
6502 Ferrochelatase DKFZp686P18130 0.0035
1591 Ferrochelatase, mitochondrial FECH 0.0035
939 50S ribosomal protein L3 rplC 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
1313 Lactoylglutathione lyase GLO1 0.0034
4217 Telomerase reverse transcriptase TERT 0.0034
3937 Fatty-acid amide hydrolase FAAH 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
2207 Rhodopsin RHO 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
6048 Troponin C, skeletal muscle TNNC2 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
1864 RET proto-oncogene RET 0.0032
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0032
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0032
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0032
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0032
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0032
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0032
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0032
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0032
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0032
3587 Gastrotropin FABP6 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
6500 Phospholipase A2 PLA2G1B 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0031
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0031
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0031
751 Potassium channel subfamily K member 6 KCNK6 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
164 Histamine H4 receptor HRH4 0.0031
611 Retinal dehydrogenase 1 ALDH1A1 0.0031
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0031
735 Alanine aminotransferase 1 GPT 0.0031
3904 Alanine aminotransferase 2 GPT2 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.003
6493 Cytochrome c oxidase subunit 6C COX6C 0.003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.003
6559 Cytochrome c oxidase subunit 2 ctaC 0.003
6669 Cytochrome c oxidase subunit 2 ctaC 0.003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.003
6558 Cytochrome c oxidase subunit 1 ctaD 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.003
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0029
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0029
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0029
172 Potassium channel subfamily K member 1 KCNK1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
1525 Heparin-binding growth factor 2 FGF2 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0028
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0028
2540 Choloylglycine hydrolase cbh 0.0028
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0028
1063 Signal transducer and activator of transcription 5B STAT5B 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1243 Cathepsin D CTSD 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0027
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2320 Thymidine kinase, cytosolic TK1 0.0027
291 Nitric-oxide synthase, endothelial NOS3 0.0026
6501 Fatty acid-binding protein, liver FABP1 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6859 Protein S100-A4 S100A4 0.0025
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
1360 Sphingomyelin phosphodiesterase SMPD1 0.0025
1374 Natriuretic peptides B NPPB 0.0025
1827 Gap junction alpha-1 protein GJA1 0.0025
1908 Vascular cell adhesion protein 1 VCAM1 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
896 Glutathione S-transferase Mu 1 GSTM1 0.0025
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
6218 Pannexin-1 PANX1 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
268 Adenosine A2b receptor ADORA2B 0.0024
65 Matrix metalloproteinase-9 Not Available 0.0023
4226 Uridine phosphorylase 2 UPP2 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
3917 Methylenetetrahydrofolate reductase MTHFR 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
2091 Endoplasmin HSP90B1 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
6163 Copper-transporting ATPase 2 ATP7B 0.0021
6165 Copper-transporting ATPase 1 ATP7A 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
76 Nitric-oxide synthase, brain NOS1 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
4878 Glycoprotein hormones alpha chain CGA 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.002
1072 Granzyme B GZMB 0.002
4877 Beta-mannanase man 0.002
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.002
4850 Beta-2-glycoprotein 1 APOH 0.002
4856 CD209 antigen CD209 0.002
4889 Ig epsilon chain C region IGHE 0.002
4869 Major capsid protein A430L 0.002
4852 Reticulon-4 receptor RTN4R 0.002
4880 Membrane cofactor protein CD46 0.002
757 Fusion glycoprotein F0 F 0.002
4875 Fusion glycoprotein F0 F 0.002
4721 Beta-1,4-mannanase manA 0.002
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.002
1354 Beta-glucuronidase GUSB 0.002
4189 Alpha-galactosidase A GLA 0.002
4845 ADAM 33 ADAM33 0.002
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.002
3352 Structural polyprotein Not Available 0.002
3628 Structural polyprotein Not Available 0.002
4892 Structural polyprotein Not Available 0.002
4152 Superoxide dismutase [Cu-Zn] SOD1 0.002
760 Fibroblast growth factor 1 FGF1 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
1253 Interferon gamma IFNG 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
6858 Inactive carboxylesterase 4 CES1P1 0.0017
793 T-cell surface antigen CD2 CD2 0.0017
4861 Interleukin-6 receptor alpha chain IL6R 0.0017
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0017
3837 Cytokine receptor common beta chain CSF2RB 0.0017
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0017
1268 Neuropeptide S receptor NPSR1 0.0017
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
4890 Hemagglutinin HA 0.0016
6566 Hemagglutinin Not Available 0.0016
1379 Interleukin-12 subunit beta IL12B 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
1184 Interferon beta IFNB1 0.0015
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
6677 Myelin P2 protein PMP2 0.0015
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1859 Prostatic acid phosphatase ACPP 0.0014
3140 Hemagglutinin-neuraminidase HN 0.0014
3609 Hemagglutinin-neuraminidase HN 0.0014
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0014
3444 Cyanovirin-N Not Available 0.0014
554 Low-density lipoprotein receptor LDLR 0.0014
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0014
852 Heparin cofactor 2 SERPIND1 0.0014
3221 Cytochrome c4 cc4 0.0014
4787 Envelope glycoprotein gp160 env 0.0013
4820 Envelope glycoprotein gp160 env 0.0013
5727 Envelope glycoprotein gp160 env 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
595 Fibrinogen alpha chain FGA 0.0013
4666 Fucose-binding lectin PA-IIL lecB 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
2372 Bifunctional tail protein 9 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
3480 Mannan endo-1,4-beta-mannosidase manA 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
1439 Lactotransferrin LTF 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0011
3814 Complement C1r subcomponent C1R 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
2430 Chondroitinase B cslB 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
6307 Ig gamma-2 chain C region IGHG2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2581 Chondroitinase AC cslA 0.001
309 Antithrombin-III SERPINC1 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
6847 Lactase-phlorizin hydrolase LCT 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2298 Cytochrome P450-cam camC 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
4785 Ig gamma-1 chain C region IGHG1 0.0009
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
4920 Peroxidase/catalase katG 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
798 Osteocalcin BGLAP 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
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