DT-Web: DB01129

Identification

Name

Rabeprazole

Accession Number

DB01129 (APRD01212)

Type

small molecule

Description

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

359.443

Groups

approved

Monoisotopic Weight

359.130362243

Pharmacology

Indication

For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.

Mechanism of action

Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H⁺/K⁺ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.

Absorption

Absolute bioavailability is approximately 52%.

Protein binding

96.3% (bound to human plasma proteins)

Biotransformation

Hepatic

Route of elimination

Following a single 20 mg oral dose of 14C-labeled rabeprazole, approximately 90% of the drug was eliminated in the urine, primarily as thioether carboxylic acid; its glucuronide, and mercapturic acid metabolites.

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	Rabeprazole may decrease the serum levels and therapeutic effects of atazanavir.
Cefditoren	Proton pump inhibitors such as rabeprazole may decrease the serum concentration of cefditoren. If possible, avoid use of cefditoren with proton pump inhibitors (PPIs). Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of PPIs can not be avoided.
Clopidogrel	Rabeprazole may decrease serum concentrations of the active metabolite(s) of clopidogrel. Due to the possible risk for impaired clopidogrel effectiveness with this combination, clinicians should carefully consider the need for concurrent rabeprazole therapy in patients receiving clopidogrel. Monitor response to clopidogrel closely when using clopidogrel with rabeprazole. Whether there are differences among individual proton pump inhibitors is unclear. Other acid-lowering therapies (e.g., H2-receptor antagonists, antacids, etc.) do not appear to share this interaction with clopidogrel.
Dasatinib	Rabeprazole may decrease the serum level of dasatinib.
Digoxin	Rabeprazole increases the effect of digoxin
Enoxacin	Rabeprazole may decrease the absorption of enoxacin.
Indinavir	Omeprazole decreases the absorption of indinavir
Itraconazole	The proton pump inhibitor, rabeprazole, may decrease the absorption of itraconazole.
Ketoconazole	The proton pump inhibitor, rabeprazole, may decrease the absorption of ketoconazole.
Rilpivirine	Proton-pump inhibitors increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Tretinoin	The moderate CYP2C8 inhibitor, Rabaprazole, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Rabaprazole is initiated, discontinued to dose changed.

Food Interactions

Take without regard to meals.
Take without regard to meals. Food may slow absorption rate but extent of absorption is not affected.

Potassium-transporting ATPase alpha chain 1
Name	Potassium-transporting ATPase alpha chain 1
Gene Name	ATP4A
Pharmacological action	yes
Actions	inhibitor
References	Langtry HD, Markham A: Rabeprazole: a review of its use in acid-related gastrointestinal disorders. Drugs. 1999 Oct;58(4):725-42. - Pubmed Carswell CI, Goa KL: Rabeprazole: an update of its use in acid-related disorders. Drugs. 2001;61(15):2327-56. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.3081

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Shimizu M, Uno T, Yasui-Furukori N, Sugawara K, Tateishi T: Effects of clarithromycin and verapamil on rabeprazole pharmacokinetics between CYP2C19 genotypes. Eur J Clin Pharmacol. 2006 Aug;62(8):597-603. Epub 2006 Jun 17. - Pubmed Li XQ, Andersson TB, Ahlstrom M, Weidolf L: Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7. - Pubmed
DTHybrid score	0.672
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Shimizu M, Uno T, Yasui-Furukori N, Sugawara K, Tateishi T: Effects of clarithromycin and verapamil on rabeprazole pharmacokinetics between CYP2C19 genotypes. Eur J Clin Pharmacol. 2006 Aug;62(8):597-603. Epub 2006 Jun 17. - Pubmed Li XQ, Andersson TB, Ahlstrom M, Weidolf L: Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7. - Pubmed
DTHybrid score	0.4901
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3039
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.516
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Li XQ, Andersson TB, Ahlstrom M, Weidolf L: Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7. - Pubmed Li XQ, Andersson TB, Ahlstrom M, Weidolf L: Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7. - Pubmed
DTHybrid score	0.5029
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Li XQ, Andersson TB, Ahlstrom M, Weidolf L: Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7. - Pubmed Li XQ, Andersson TB, Ahlstrom M, Weidolf L: Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7. - Pubmed
DTHybrid score	0.5047

ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	Suzuki K, Doki K, Homma M, Tamaki H, Hori S, Ohtani H, Sawada Y, Kohda Y: Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy. Br J Clin Pharmacol. 2009 Jan;67(1):44-9. Epub 2008 Nov 17. - Pubmed
DTHybrid score	0.2792

Id	Partner name	Gene Name	Score
1588	Multidrug resistance protein 1	ABCB1	0.2953
4924	Cytochrome P450 2C8	CYP2C8	0.2601
4118	Cytochrome P450 3A5	CYP3A5	0.2109
6030	Cytochrome P450 2B6	CYP2B6	0.1746
6013	Cytochrome P450 2E1	CYP2E1	0.1721
6107	Cytochrome P450 3A7	CYP3A7	0.1426
5718	Cytochrome P450 2A6	CYP2A6	0.1138
587	Serum albumin	ALB	0.0947
20	Prostaglandin G/H synthase 1	PTGS1	0.0931
1898	Cytochrome P450 1B1	CYP1B1	0.0924
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0864
6106	Cytochrome P450 2C18	CYP2C18	0.0827
492	Histamine H1 receptor	HRH1	0.0713
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0664
862	Multidrug resistance-associated protein 1	ABCC1	0.0657
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0653
824	Sodium-dependent serotonin transporter	SLC6A4	0.0609
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0541
1729	Solute carrier family 22 member 6	SLC22A6	0.054
6145	Solute carrier family 22 member 1	SLC22A1	0.0504
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0502
290	Prostaglandin G/H synthase 2	PTGS2	0.0497
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0494
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0482
831	D(2) dopamine receptor	DRD2	0.0471
556	Alpha-1A adrenergic receptor	ADRA1A	0.0464
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0462
468	Cytochrome P450 4A11	CYP4A11	0.0456
3811	Cytochrome P450 19A1	CYP19A1	0.0452
6144	Solute carrier family 22 member 2	SLC22A2	0.0448
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0442
766	Beta-2 adrenergic receptor	ADRB2	0.042
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0409
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0408
776	Bile salt export pump	ABCB11	0.0407
318	Alpha-2A adrenergic receptor	ADRA2A	0.0397
193	Beta-1 adrenergic receptor	ADRB1	0.0381
136	Estrogen receptor	ESR1	0.0378
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0377
713	Sodium-dependent dopamine transporter	SLC6A3	0.036
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0344
118	Organic cation/carnitine transporter 2	SLC22A5	0.0343
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0338
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0336
817	DNA topoisomerase 2-alpha	TOP2A	0.0332
23	D(1A) dopamine receptor	DRD1	0.0328
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0327
3941	Amine oxidase [flavin-containing] A	MAOA	0.0326
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0323
6142	Solute carrier family 22 member 8	SLC22A8	0.0319
731	HIV-1 protease	HIV-1 protease	0.0318
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0315
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0314
632	Alpha-1B adrenergic receptor	ADRA1B	0.0313
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0297
2164	Multidrug resistance-associated protein 4	ABCC4	0.0287
871	Glucocorticoid receptor	NR3C1	0.0287
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0286
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0281
6147	Solute carrier family 22 member 3	SLC22A3	0.027
847	Mu-type opioid receptor	OPRM1	0.0269
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0261
36	Insulin receptor	INSR	0.0258
844	Epidermal growth factor receptor	EGFR	0.0258
6143	Solute carrier family 22 member 7	SLC22A7	0.0243
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0239
260	Cytochrome P450 51	ERG11	0.0238
761	Cytochrome P450 51	ERG11	0.0238
3163	Cytochrome P450 51	cyp51	0.0238
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0234
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0228
467	Delta-type opioid receptor	OPRD1	0.0227
3939	Amine oxidase [flavin-containing] B	MAOB	0.0225
638	D(3) dopamine receptor	DRD3	0.0218
789	Alpha-1D adrenergic receptor	ADRA1D	0.0215
696	Kappa-type opioid receptor	OPRK1	0.0214
465	Calmodulin	CALM1	0.0214
6148	Multidrug resistance-associated protein 7	ABCC10	0.0211
725	5-hydroxytryptamine 1D receptor	HTR1D	0.021
629	Alpha-2B adrenergic receptor	ADRA2B	0.021
833	Organic cation/carnitine transporter 1	SLC22A4	0.0208
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0207
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0206
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0205
504	Mast/stem cell growth factor receptor	KIT	0.0202
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0201
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0201
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.02
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0199
6137	Multidrug resistance-associated protein 6	ABCC6	0.0198
777	Tumor necrosis factor	TNF	0.0198
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0197
6014	Cytochrome P450 2A13	CYP2A13	0.0193
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0193
122	P2Y purinoceptor 12	P2RY12	0.0193
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0192
6220	Aryl hydrocarbon receptor	AHR	0.019
6031	Cytochrome P450 3A43	CYP3A43	0.0186
1024	Solute carrier family 22 member 11	SLC22A11	0.0182
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0179
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0177
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0177
378	Alpha-2C adrenergic receptor	ADRA2C	0.0176
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0175
3923	Cholinesterase	BCHE	0.0172
6182	Cytochrome P450 2J2	CYP2J2	0.017
70	Type-1 angiotensin II receptor	AGTR1	0.0165
146	Androgen receptor	AR	0.0165
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0165
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0164
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0163
432	D(4) dopamine receptor	DRD4	0.0162
477	DNA topoisomerase 4 subunit A	parC	0.0162
886	DNA topoisomerase 4 subunit A	parC	0.0162
6226	DNA topoisomerase 4 subunit A	parC	0.0162
404	DNA gyrase subunit A	gyrA	0.016
6224	DNA gyrase subunit A	gyrA	0.016
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.016
1757	Myeloperoxidase	MPO	0.0158
33	Cystine/glutamate transporter	SLC7A11	0.0158
891	Dihydropteroate synthase	folP	0.0157
5359	Dihydropteroate synthase	folP	0.0157
7175	Dihydropteroate synthase	sulI	0.0157
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0156
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0156
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0154
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0154
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.015
1353	DNA topoisomerase 1	TOP1	0.0148
3552	DNA topoisomerase 1	topA	0.0148
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0148
3947	Xanthine dehydrogenase/oxidase	XDH	0.0144
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0144
407	Vascular endothelial growth factor receptor 2	KDR	0.0141
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0141
4120	NADPH--cytochrome P450 reductase	POR	0.014
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0139
571	Melatonin receptor type 1A	MTNR1A	0.0136
362	Melatonin receptor type 1B	MTNR1B	0.0136
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0133
26	Vascular endothelial growth factor receptor 3	FLT4	0.0132
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0132
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0131
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.013
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0129
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0129
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0127
32	Vascular endothelial growth factor receptor 1	FLT1	0.0127
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0126
117	Sterol O-acyltransferase 1	SOAT1	0.0125
373	Transthyretin	TTR	0.0125
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0123
869	Estrogen receptor beta	ESR2	0.0123
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
1517	Beta-3 adrenergic receptor	ADRB3	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
4604	Liver carboxylesterase 1	CES1	0.0121
6136	Multidrug resistance-associated protein 5	ABCC5	0.0121
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0121
6141	Sodium/bile acid cotransporter	SLC10A1	0.012
16	Adenosine A1 receptor	ADORA1	0.012
380	Cytochrome P450 17A1	CYP17A1	0.0119
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0119
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0118
124	Histamine H2 receptor	HRH2	0.0118
756	Sex hormone-binding globulin	SHBG	0.0116
48	Pyridoxal kinase	PDXK	0.0116
1178	Adenosine A2a receptor	ADORA2A	0.0115
474	Acetylcholinesterase	ACHE	0.0113
2449	Tubulin alpha-3 chain	TUBA1A	0.0113
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0113
2499	Tubulin beta-2C chain	TUBB2C	0.0113
992	Protein tyrosine kinase 2 beta	PTK2B	0.0112
163	D(1B) dopamine receptor	DRD5	0.0112
614	Progesterone receptor	PGR	0.0111
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0109
68	Cannabinoid receptor 1	CNR1	0.0109
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0108
1010	Cytochrome P450 51A1	CYP51A1	0.0107
6146	High affinity copper uptake protein 1	SLC31A1	0.0107
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0106
716	5-hydroxytryptamine 7 receptor	HTR7	0.0106
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0105
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0105
592	Carbonic anhydrase 4	CA4	0.0105
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0104
183	Vascular endothelial growth factor A	VEGFA	0.0104
161	Tubulin beta chain	TUBB	0.0103
312	Tubulin beta chain	TUB2	0.0103
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0102
295	Carbonic anhydrase 1	CA1	0.0102
818	50S ribosomal protein L10	rplJ	0.0102
29	Tubulin beta-1 chain	TUBB1	0.0101
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.01
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.01
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.01
6102	Arylamine N-acetyltransferase 2	NAT2	0.0099
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0099
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0099
4773	Deoxycytidine kinase	DCK	0.0098
94	5-hydroxytryptamine 4 receptor	HTR4	0.0098
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0098
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
49	Endothelin B receptor	EDNRB	0.0096
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0095
232	Corticosteroid-binding globulin	SERPINA6	0.0093
1656	CYP2B protein	CYP2B	0.0091
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0091
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0091
823	Fibroblast growth factor receptor 2	FGFR2	0.009
578	Endothelin-1 receptor	EDNRA	0.009
4228	Keratin, type II cytoskeletal 7	KRT7	0.009
904	Glutathione S-transferase P	GSTP1	0.0089
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0089
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0088
3810	Catechol O-methyltransferase	COMT	0.0088
2539	Tubulin alpha-1 chain	TUBA4A	0.0087
365	Dihydrofolate reductase	DHFR	0.0087
2381	Dihydrofolate reductase	DFR1	0.0087
2833	Dihydrofolate reductase	Not Available	0.0087
2931	Dihydrofolate reductase	folA	0.0087
3544	Dihydrofolate reductase	folA	0.0087
3682	Dihydrofolate reductase	folA	0.0087
6642	Dihydrofolate reductase	folA	0.0087
6756	Dihydrofolate reductase	dfrA	0.0087
811	Translocator protein	TSPO	0.0086
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0086
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0086
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0085
4203	Histamine N-methyltransferase	HNMT	0.0085
275	Arachidonate 5-lipoxygenase	ALOX5	0.0084
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0084
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0084
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0084
790	DNA polymerase subunit alpha B	POLA2	0.0084
106	Cannabinoid receptor 2	CNR2	0.0084
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0083
4122	Histone deacetylase 2	HDAC2	0.0082
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0082
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0081
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0081
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0081
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0081
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0081
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
2112	Toll-like receptor 9	TLR9	0.008
273	Apoptosis regulator Bcl-2	BCL2	0.008
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0079
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0079
173	Toll-like receptor 7	TLR7	0.0079
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0078
357	Carbonic anhydrase 2	CA2	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
738	Monocarboxylate transporter 1	SLC16A1	0.0077
908	Glutathione S-transferase theta-1	GSTT1	0.0077
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0076
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0075
3932	Glutathione S-transferase A2	GSTA2	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
461	Glycine receptor subunit alpha-3	GLRA3	0.0074
482	Glycine receptor subunit alpha-1	GLRA1	0.0074
427	Substance-P receptor	TACR1	0.0074
6043	Putative G-protein coupled receptor 44	GPR44	0.0073
5787	Angiopoietin-1 receptor	TEK	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0072
820	Glycine receptor subunit alpha-2	GLRA2	0.0072
1629	Transcription factor AP-1	JUN	0.0072
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0071
6020	Aldehyde oxidase	AOX1	0.0071
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0071
528	5-hydroxytryptamine 1E receptor	HTR1E	0.007
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.007
6126	Carbonic anhydrase 7	CA7	0.007
165	FL cytokine receptor	FLT3	0.007
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.007
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.007
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.007
4311	tRNA	TRDMT1	0.0069
4325	tRNA	trmD	0.0069
4328	tRNA	trmD	0.0069
921	Glutamate receptor 2	GRIA2	0.0069
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0069
1192	Sulfotransferase 1A1	SULT1A1	0.0069
814	Ryanodine receptor 1	RYR1	0.0068
1618	High affinity nerve growth factor receptor	NTRK1	0.0067
952	Dipeptidyl peptidase 4	DPP4	0.0066
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0066
856	Vitamin D3 receptor	VDR	0.0066
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0065
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0065
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0064
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0064
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0064
6163	Copper-transporting ATPase 2	ATP7B	0.0064
6165	Copper-transporting ATPase 1	ATP7A	0.0064
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
133	Dihydropterate synthase	sulI	0.0063
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0062
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0062
3856	Fibroblast growth factor receptor 3	FGFR3	0.006
239	Coagulation factor X	F10	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
896	Glutathione S-transferase Mu 1	GSTM1	0.006
1275	Estrogen sulfotransferase	SULT1E1	0.006
936	Ephrin type-A receptor 2	EPHA2	0.006
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0059
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0059
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0059
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
581	Cytochrome P450 2R1	CYP2R1	0.0059
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0058
6766	O-GlcNAcase BT_4395	BT_4395	0.0058
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0058
6085	Fatty acid-binding protein, intestinal	FABP2	0.0058
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
634	Squalene monooxygenase	SQLE	0.0057
7196	Squalene monooxygenase	ERG1	0.0057
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0057
469	Annexin A1	ANXA1	0.0057
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
1714	Mitogen-activated protein kinase 3	MAPK3	0.0056
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0055
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0055
284	DNA-directed RNA polymerase beta chain	rpoB	0.0055
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0055
4192	DNA topoisomerase 2-beta	TOP2B	0.0055
84	Nuclear receptor 0B1	NR0B1	0.0055
6506	Stathmin-4	STMN4	0.0055
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0055
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0055
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0054
24	Thymidylate synthase	TMP1	0.0054
359	Thymidylate synthase	TYMS	0.0054
2626	Thymidylate synthase	thyA	0.0054
2729	Thymidylate synthase	thyA	0.0054
5352	Thymidylate synthase	THYA	0.0054
780	Retinoic acid receptor RXR-gamma	RXRG	0.0053
518	Peroxidase/catalase T	katG	0.0053
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0053
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0053
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
1050	Bile salt sulfotransferase	SULT2A1	0.0052
737	Mineralocorticoid receptor	NR3C2	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3426	Glutamine synthetase	glnA	0.0052
3987	Glutamine synthetase	GLUL	0.0052
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
6432	Transporter	snf	0.0051
976	Platelet glycoprotein IX	GP9	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.005
1650	Heme carrier protein 1	SLC46A1	0.005
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.005
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.005
4103	Proteasome subunit beta type 2	PSMB2	0.005
4102	Proteasome subunit beta type 5	PSMB5	0.005
4101	Proteasome subunit beta type 1	PSMB1	0.0049
6044	Serum paraoxonase/lactonase 3	PON3	0.0049
563	Thyroid peroxidase	TPO	0.0048
1852	Microtubule-associated protein 2	MAP2	0.0048
88	Retinoic acid receptor RXR-beta	RXRB	0.0048
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0048
3809	Estrogen-related receptor gamma	ESRRG	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
54	Prothrombin	F2	0.0046
4237	50S ribosomal protein L22	rplV	0.0046
1992	Vitamin D-binding protein	GC	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0045
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0045
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0044
153	Dopamine beta-hydroxylase	DBH	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
5934	Cytochrome P450 26A1	CYP26A1	0.0044
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0043
3830	Calreticulin	CALR	0.0043
7	Nitric oxide synthase, inducible	NOS2	0.0043
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0043
705	Glutamate receptor 1	GRIA1	0.0043
714	Glutathione reductase, mitochondrial	GSR	0.0042
5923	Microtubule-associated protein tau	MAPT	0.0042
5924	Microtubule-associated protein 4	MAP4	0.0042
3957	Adenosine deaminase	ADA	0.0042
164	Histamine H4 receptor	HRH4	0.0042
1374	Natriuretic peptides B	NPPB	0.0041
1648	Elastin	ELN	0.0041
1827	Gap junction alpha-1 protein	GJA1	0.0041
1908	Vascular cell adhesion protein 1	VCAM1	0.0041
1176	Mitogen-activated protein kinase 1	MAPK1	0.0041
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0041
459	Retinoic acid receptor RXR-alpha	RXRA	0.0041
6034	Hydroxyindole O-methyltransferase	ASMT	0.0041
6035	Nuclear receptor ROR-beta	RORB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6036	Eosinophil peroxidase	EPX	0.0041
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.004
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.004
2236	Casein kinase II subunit alpha	CSNK2A1	0.004
1541	Metalloproteinase	mmp20	0.0039
251	Alcohol dehydrogenase 1A	ADH1A	0.0039
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0038
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0038
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0038
85	Growth hormone receptor	GHR	0.0038
1864	RET proto-oncogene	RET	0.0037
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0037
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0037
174	Sigma 1-type opioid receptor	SIGMAR1	0.0037
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0037
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0037
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0037
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0037
484	Tyrosine-protein kinase ABL2	ABL2	0.0037
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
3639	Thymidine phosphorylase	deoA	0.0036
3936	Thymidine phosphorylase	TYMP	0.0036
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0036
4217	Telomerase reverse transcriptase	TERT	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
765	Indoleamine 2,3-dioxygenase	IDO1	0.0035
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0035
6149	Solute carrier family 22 member 10	SLC22A10	0.0035
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0035
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0035
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0035
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0035
268	Adenosine A2b receptor	ADORA2B	0.0035
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0035
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0035
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
444	Alcohol dehydrogenase 1B	ADH1B	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
3937	Fatty-acid amide hydrolase	FAAH	0.0034
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0034
558	Solute carrier family 12 member 1	SLC12A1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0033
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0033
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0033
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0033
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0033
6167	Organic solute transporter subunit beta	OSTB	0.0033
6166	Organic solute transporter subunit alpha	OSTA	0.0033
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0032
569	Retinal dehydrogenase 2	ALDH1A2	0.0032
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0032
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0032
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0031
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0031
293	Gamma-glutamyl hydrolase	GGH	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
4226	Uridine phosphorylase 2	UPP2	0.0031
5300	Antigen peptide transporter 1	TAP1	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
611	Retinal dehydrogenase 1	ALDH1A1	0.003
6174	50S ribosomal protein L32	rpmF	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
517	Alcohol dehydrogenase 1C	ADH1C	0.003
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.003
1196	Complement decay-accelerating factor	CD55	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
1760	Aminopeptidase N	ANPEP	0.0029
6843	Aminopeptidase N	pepN	0.0029
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0029
1569	G1/S-specific cyclin-D1	CCND1	0.0029
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0029
4225	Uridine phosphorylase 1	UPP1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0028
5798	Mitogen-activated protein kinase 11	MAPK11	0.0028
2320	Thymidine kinase, cytosolic	TK1	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0028
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0028
6824	Tyrosine-protein kinase Lyn	LYN	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0027
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
5626	Nucleoside diphosphate kinase B	NME2	0.0027
751	Potassium channel subfamily K member 6	KCNK6	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
319	Opioid receptor, sigma 1	OPRS1	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2216	Fibroblast growth factor receptor 4	FGFR4	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
267	Plasminogen activator inhibitor 1	SERPINE1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0027
413	Amidophosphoribosyltransferase	PPAT	0.0026
2515	Amidophosphoribosyltransferase	purF	0.0026
3714	Amidophosphoribosyltransferase	purF	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
1630	Integrin beta-2	ITGB2	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
6131	Carbonic anhydrase 14	CA14	0.0026
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0026
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0026
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0026
2808	Chloramphenicol acetyltransferase 3	cat3	0.0026
3959	Cell division protein kinase 4	CDK4	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
6138	Multidrug resistance protein 3	ABCB4	0.0025
172	Potassium channel subfamily K member 1	KCNK1	0.0025
760	Fibroblast growth factor 1	FGF1	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0024
400	Coagulation factor IX	F9	0.0024
5461	Coagulation factor IX	F9	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6221	Steroid hormone receptor ERR1	ESRRA	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0024
6228	Nuclear receptor coactivator 1	NCOA1	0.0024
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6122	Carbonic anhydrase 3	CA3	0.0024
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0024
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0024
6241	Nuclear receptor coactivator 2	NCOA2	0.0024
6070	Nischarin	NISCH	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
719	Retinoic acid receptor responder protein 1	RARRES1	0.0024
770	Retinoic acid-induced protein 3	GPRC5A	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3808	Dihydropteroate synthase 2	folP2	0.0023
3601	Dihydropteroate synthase 1	folP1	0.0023
3807	Dihydropteroate synthase 1	folP1	0.0023
3086	Plasmepsin-2	Not Available	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
2417	Chloramphenicol acetyltransferase	cat	0.0023
3278	Chloramphenicol acetyltransferase	cat	0.0023
162	Retinoic acid receptor gamma-1	RARG	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
2810	Dr hemagglutinin structural subunit	draA	0.0023
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0023
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0023
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0023
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0023
65	Matrix metalloproteinase-9	Not Available	0.0023
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0023
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0023
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0023
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
822	Aldose reductase	AKR1B1	0.0023
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0022
5294	Nucleoside diphosphate kinase A	NME1	0.0022
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0022
604	Vitamin K-dependent protein Z	PROZ	0.0022
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
3404	Exotoxin A	eta	0.0022
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
291	Nitric-oxide synthase, endothelial	NOS3	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
2599	Tyrosine-protein kinase HCK	HCK	0.0021
422	Vitamin K-dependent protein C	PROC	0.002
1245	Vitamin K-dependent protein S	PROS1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
1058	Cell division protein kinase 5	CDK5	0.002
572	Integrin alpha-L	ITGAL	0.002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
489	Monocarboxylate transporter 2	SLC16A7	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
6837	Serine/threonine-protein kinase 17B	STK17B	0.0018
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0018
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0018
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
1039	Histone deacetylase 9	HDAC9	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0017
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0017
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0017
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0016
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0016
798	Osteocalcin	BGLAP	0.0016
144	Hemoglobin subunit alpha	HBA1	0.0016
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0016
1243	Cathepsin D	CTSD	0.0016
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0016
3007	Carbonic anhydrase 12	CA12	0.0016
4205	Carbonic anhydrase 9	CA9	0.0016
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0016
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0016
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6168	Solute carrier family 22 member 16	SLC22A16	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0015
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
6171	Solute carrier family 28 member 3	SLC28A3	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
369	Coagulation factor VII	F7	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
3913	Glutamic acid decarboxylase	GAD65	0.0014
2240	Cell division protein kinase 2	CDK2	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6859	Protein S100-A4	S100A4	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0013
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0013
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0013
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6218	Pannexin-1	PANX1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
2021	Thrombomodulin	THBD	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0012
76	Nitric-oxide synthase, brain	NOS1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
2408	Tyrosine-protein kinase SYK	SYK	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
3587	Gastrotropin	FABP6	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
5818	Folate receptor alpha	FOLR1	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6042	Prostaglandin reductase 2	PTGR2	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
1792	Tissue-type plasminogen activator	PLAT	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
2207	Rhodopsin	RHO	0.0008
1867	Major prion protein	PRNP	0.0008
4948	Cytochrome c-553	Not Available	0.0008
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
2298	Cytochrome P450-cam	camC	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
1313	Lactoylglutathione lyase	GLO1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
125	DNA polymerase beta	POLB	0.0007
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
3221	Cytochrome c4	cc4	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1507	Cytochrome c	CYCS	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01129 - Rabeprazole

Targets

Enzymes

Transporters

Predictions